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enn State Univ., University Park, PA }hio State Univ., Columbus, Ohio }hie State Univ., Columbus, Ohio Univ. of Illinois, Urbana, IL B.So M.S. Ph.D. Post-Doe 1972 1974 1976 1977 Biology Zoo]ogy(Radiat.Biol.) Zoology(Radial.Biol.) Physiol.-Biophys. RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronolooical order, previous em;~Ioyment, experience, and honors. Include present membership on any Federal Government punic advisor~ committee. List, in chronological order, the titles and com- plete references to aH publications dudng the past three yearn an~ to representative earlier publlcatlons pe~inent to th~s application. DO NOT EXCEED~VO PAGES. Research Associate, Cancer Research Unit, Allegheny General Hospital Assistant Professor, Radiation Therapy, Hahnemann Medical College Associate Professor, Radiation Therapy, Hahnemann Medical College Associate Research Professor, Radiology, George Washington University Associate Staff Scientist, National Council on Radiation Protection Staff Scientist, National Council on Radiation Protection Professor of Oneology, Mayo Medical School Senior Associate Consultant, Mayo Clinic and Mayo Foundation 1977-1979 1979-1982 1982 1982-1988 1982-1986 1987-1988 1988-Present 1988-Present Honors and Awards Sigma Xi, 1974; Argonne National Laboratory Symposium (Mechanisms of Oneogenesis) Award, 1974; National Research Service Award (NIH Postdoctoral Fellowship), 1976, 1977; NATO Advanced Study Institute, 1978; Invited speaker for 32nd Annum Symposium on Fundamental Cancer Research, M.D. Anderson Hospital and Tumor Institute, 1979; Travel award to Combined Modality Cancer Treatment Conference in Key Biscayne, 1979; Radiation Research Travel Awards to 6th (Tokyo, 1979), 7th (Amsterdam, 1983), and 8th (Edinburgh, 1987) International Congresses of Radiation Research. PUBLICATIONS.: Koval, T.M., W.C. Myser, and W.F. Hink. 1975. Effect of x-irradiation on cell division, oxygen consump-tion, and growth medium pH of an insect cell line cultured in vitro, Radiation Research 64:524-532. Koval. T.M., W.C. Myser, and W.F. Hink. 1976. Effects of x-irradiation on amino acid utilization of an insect cell line cultured in vitro. Radiation Research 67:305-313. Koval, T.M. and W.F. Hink. 1977. Increased polyhedra production in an insect cell line following x- irradiation. J. hwertebrate Pathology 30:112-113. Koval.T.M., R.W. Hart, W.C. Myser, and W.F. Hink. 1977. A comparison of survival and repair of UV- induced DNA damage in cultured insect versus mammalian cells. Genetics 87:513-518. Koval. T.M., W.C. Myser, R.W. Hart, and W.F. Hink. 1978. Comparison of survival and unscheduled DNA synthesis between an insect and a mammalian cell line following x-ray treatments. Mutation Research 49:431-435. K0val. T.M. 1978. A method for obtaining high plating effieieneies with cultured insect ceils. Experientia 34:674-676. Koval. T.M., R.W. Hart, W.C. Myser, and W.F. Hink. 1979. DNA single strand break repair in cultured insect and mammalian cells after x-irradiation. International J. of Radiation Biology 35:183-188. Koval. T,M. 1980. Relative responses of mammalian and insect cells. In H.R. Withers and R.E. Meyn, eds,, i~ Biology in Cancer Research. Raven Press. New York, pp, 169-184. Koval.T.M. and SJ. Kaufinan. 1981. Maintenance of DNA repair capacity in differentiating rat muscle ceils in vitro. Photochemistry and Photoblology 33:403-406. Raikow, R.B., J.P. Okunewiek, MJ. Buffow, D.L. Jones, BJ. Brozovich, P,R. Seeman, and T,M, Koval, 198 I. Potentiating effect of ber~zoIa]pyrcne and caffeine en Friend viral leukemogenesis. Carcinogenesis 2:1-6, Koval. T.M, 1983. Intrinsic resistance to the lethal effect~ of x-irradiation in insect and arachnid cells. Proc, Natl. Acad. Sci. USA 80:4752-4755. Koval, T.M. 1983. RadiosensitNity of cuittared insect cells: I. Lepidoptera. Radiation Research 96:1 I8-I26. FF

-' "~tiew:,l, T..~. 19S3. R~,dk~:qe~itivib" of ctflt~red in~ect cells: II. Diptera. Radiat;onResearch administration of 1,2-din:ethylhydrazine. J. Toxicology an:l Environm~ntaI Health 13:1 I7-124. Koval. T.M, 1984. Mult~pI~asie survival reap:rose of a radioresisuntIepidopteran cell line. Radiation Research 98:642-648. Koval. T,M, and S.P. Tomasovic. 1984. Ceil survival and heat-stress protein synlhesis in a ~ cell line. In J. Overgaard, ed., Hyperthermic Ontology 19~4, Vol. 1. Taylor and Francis Ltd., London, pp. 83-86. Tomasovic, S.P. and .T, M, K#vo]. 1985. Relationship between cell supeival and heat-stress protein synthesis in a Drosophila line. International J. of Radiation Biology 48:635-650. Koval. T,M, 1986. Inducible repair of ionizing radiation damage in higher eukaD'otic cells. Mutation Research 173:291-293. Ewing, D., T. M. K~vol and H. L. Walton. 1986. Radiation sensitization by oxygen of in vitro mammalian cells: Is 02 invoNed? Radiation Research 10~:356-365. Koval. T.M. 1986. Enhanced survival by photoreactivation and liquid-holding following UV damage of TN- 368 insect cells. Mutation Research 166:149-156. Koval. T.M. 1987. Photoreaetivation of UV damage in cultured Drosophila cells. Experientia 43:445-446. Koyal. T.M. 1987. Factors to consider in performing survival studies with insect cells. In Vitro Cellular and Developmental Biology 23:733-737. I<oval. T.M. and E.R. Kazmar. 1988. DNA double strand break repair in eukm3,otic cell lines having radically different radiosensitivities. Radiat. Res. 113:268-277. Koval. T,M, 1988. Enhanced recovery from ionizing radiation damage in a lepidopteran insect cell line. Radiation Research 115:413-420. Koval. T,M, and E.R. Kazmar. 1988. Eluting solution composition affects DNA double strand break analysis by filter elution. Int. J. Radiat. Biol. 54:739-747. Koval. T.M. 1989. Split-dose and liquid-holding recovery following alkylating agent treatment of an ionizing radiation resistant cell line. Abstracts of the 37th Annual Meeting of the Rod. Res. See. p. 93. Koval. T.M. 1989. Methods for determining the survival of cultured insect cells. Tissue Culture Methods 12:43-46. Koval. T.M, D.L. Suppes, and J.M. Kramer. 1990. Heat resistance and thermotoleranee in a radioresistant insect cell line. Abstracts of the 38th Annual Meeting of ~he Radiation Research Society. p. 123. Koval. T.M., D.L. Suppes, J.M. Kramer, and N.L. Dodge. 1990. Regulation of cell attachment and growth of a lepidopteran cell line by medium pH. In Vitro Cellular and Developmental Biology 26:31A. Koval. T.M., D.L. Suppes, J.M. Kramer, and N.L. Dodge. 1990. Isolation of x-ray- and ultraviolet-light- sensitive variants of a highly radioresistant eukaryotic cell line. Prec. Am. Assoc. Cancer Research 31:75. Koval. T,M, and D.L. Suppes. 1990. pH dependency of cell attaehment and grow that both clonal and subculture densities of cultured lepidopteran cells. In Vitro Cell. and Dev. Biology 26:665-670. Koval. T.M. 1991. Recovery from exposure to DNA-damaging chemicals in radiation resistant insect cells. Mutation Research 262:219-225. Svingen, P.A., D.J. Schaid, D.L. Suppes, ~, and J.S. Kovaeh. 1991. Rat glioma model for evaluation of radiosensitization. Proceedings of the American Association for Cancer Research 32:388. Koval, T,M. 1991. Radiation-inducible processes in invertebrate cells. In Vitro Cell. and Dev. Biol 27:36A. Gutta, K.V., K. K. Wang, D.A. Ahlquist, T, M. KoTa!, G.L. Alexander, and M.R. Pittelkow. 1991. The use of hematoporphyrin derivative as a radio~nsitizer in human eholangiocareinoma implanted in nude mice. Gastroenterology 100(512]):A367. Koval. T.M. 1991. Gamma-ray- and UV-sensltive stnfins of a radioresistant cell line: isolation and cross- sensitivity to other agents. Radiat. Res. 127:58-63. Hayostek, C.J. and T.M~ Koval. 1991. Interactions of levamisole with radiation and/or 5-FU in human tumor cells. Prec. 9th Int. Cong. Radiat. Res., p. 367. Koval. T.M, and D.L. Suppes. 1991. Continuous low dose rate and chronic acute studies with resistant insect cells. Prec. 9th Int. Cong. Rod. Res,, p. 230. Kane, WJ., T.V. McCaffrey, T.D. Wang, and _T.,M, .Kgva!. 1992. Tl~e effect of previous fractionated irradiation on the process of tissue expansion in the rabbit. Arch. Ore. Head Neck Surg. In Press. Koval.~,lVl. and D.L. Suppes. 1992. Heat resistance and thennotolerance in an x-ray- and UV-resistant cell line, Int. J. Radiat. Biol. In Press, Schwartz, R,S., T.M. Koval, W.D. Edwards, A.R, Camrad, K,R. Bailey, K. Browne, R.E. Vlietstra, and D,R. Holmes. 1991. The effect of external beam irradiation on neointimal hy~erplasia following experimental coronaD" arlcry injury. Journal of the American College of Cardiology. In Press. Koval. T,M. I991, Radiation-inducible processes in cultured Iepidop~eran cells. In M.J. Fraser, Eds., 8th Intcrnatl. Conf, Invertebrate and Fish Tim Cult. Tim Cult. Assc~:. Inic,, Columbia, MD., pp. 168-177.