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enn State Univ., University Park, PA
}hio State Univ., Columbus, Ohio
}hie State Univ., Columbus, Ohio
Univ. of Illinois, Urbana, IL
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronolooical
order, previous em;~Ioyment, experience,
and honors. Include present membership on any Federal Government punic advisor~ committee. List, in
chronological order, the titles and com-
plete references to aH publications dudng the past three yearn an~ to representative earlier
publlcatlons pe~inent to th~s application. DO NOT
Research Associate, Cancer Research Unit, Allegheny General Hospital
Assistant Professor, Radiation Therapy, Hahnemann Medical College
Associate Professor, Radiation Therapy, Hahnemann Medical College
Associate Research Professor, Radiology, George Washington University
Associate Staff Scientist, National Council on Radiation Protection
Staff Scientist, National Council on Radiation Protection
Professor of Oneology, Mayo Medical School
Senior Associate Consultant, Mayo Clinic and Mayo Foundation
Honors and Awards
Sigma Xi, 1974; Argonne National Laboratory Symposium (Mechanisms of Oneogenesis) Award, 1974;
National Research Service Award (NIH Postdoctoral Fellowship), 1976, 1977; NATO Advanced Study
Institute, 1978; Invited speaker for 32nd Annum Symposium on Fundamental Cancer Research, M.D.
Anderson Hospital and Tumor Institute, 1979; Travel award to Combined Modality Cancer Treatment
Conference in Key Biscayne, 1979; Radiation Research Travel Awards to 6th (Tokyo, 1979), 7th
(Amsterdam, 1983), and 8th (Edinburgh, 1987) International Congresses of Radiation Research.
Koval, T.M., W.C. Myser, and W.F. Hink. 1975. Effect of x-irradiation on cell division, oxygen
consump-tion, and growth medium pH of an insect cell line cultured in vitro, Radiation Research
Koval. T.M., W.C. Myser, and W.F. Hink. 1976. Effects of x-irradiation on amino acid utilization of
insect cell line cultured in vitro. Radiation Research 67:305-313.
Koval, T.M. and W.F. Hink. 1977. Increased polyhedra production in an insect cell line following x-
irradiation. J. hwertebrate Pathology 30:112-113.
Koval.T.M., R.W. Hart, W.C. Myser, and W.F. Hink. 1977. A comparison of survival and repair of UV-
induced DNA damage in cultured insect versus mammalian cells. Genetics 87:513-518.
Koval. T.M., W.C. Myser, R.W. Hart, and W.F. Hink. 1978. Comparison of survival and unscheduled
DNA synthesis between an insect and a mammalian cell line following x-ray treatments. Mutation
K0val. T.M. 1978. A method for obtaining high plating effieieneies with cultured insect ceils.
Koval. T.M., R.W. Hart, W.C. Myser, and W.F. Hink. 1979. DNA single strand break repair in cultured
insect and mammalian cells after x-irradiation. International J. of Radiation Biology 35:183-188.
Koval. T,M. 1980. Relative responses of mammalian and insect cells. In H.R. Withers and R.E. Meyn,
eds,, i~ Biology in Cancer Research. Raven Press. New York, pp, 169-184.
Koval.T.M. and SJ. Kaufinan. 1981. Maintenance of DNA repair capacity in differentiating rat muscle
in vitro. Photochemistry and Photoblology 33:403-406.
Raikow, R.B., J.P. Okunewiek, MJ. Buffow, D.L. Jones, BJ. Brozovich, P,R. Seeman, and T,M, Koval,
198 I. Potentiating effect of ber~zoIa]pyrcne and caffeine en Friend viral leukemogenesis.
Koval. T.M, 1983. Intrinsic resistance to the lethal effect~ of x-irradiation in insect and arachnid
Natl. Acad. Sci. USA 80:4752-4755.
Koval, T.M. 1983. RadiosensitNity of cuittared insect cells: I. Lepidoptera. Radiation Research
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-' "~tiew:,l, T..~. 19S3. R~,dk~:qe~itivib" of ctflt~red in~ect cells: II. Diptera.
administration of 1,2-din:ethylhydrazine. J. Toxicology an:l Environm~ntaI Health 13:1 I7-124.
Koval. T.M, 1984. Mult~pI~asie survival reap:rose of a radioresisuntIepidopteran cell line.
Koval. T,M, and S.P. Tomasovic. 1984. Ceil survival and heat-stress protein synlhesis in a ~ cell
line. In J. Overgaard, ed., Hyperthermic Ontology 19~4, Vol. 1. Taylor and Francis Ltd., London,
Tomasovic, S.P. and .T, M, K#vo]. 1985. Relationship between cell supeival and heat-stress protein
synthesis in a Drosophila line. International J. of Radiation Biology 48:635-650.
Koval. T,M, 1986. Inducible repair of ionizing radiation damage in higher eukaD'otic cells. Mutation
Ewing, D., T. M. K~vol and H. L. Walton. 1986. Radiation sensitization by oxygen of in vitro
cells: Is 02 invoNed? Radiation Research 10~:356-365.
Koval. T.M. 1986. Enhanced survival by photoreactivation and liquid-holding following UV damage of
368 insect cells. Mutation Research 166:149-156.
Koval. T.M. 1987. Photoreaetivation of UV damage in cultured Drosophila cells. Experientia
Koyal. T.M. 1987. Factors to consider in performing survival studies with insect cells. In Vitro
Developmental Biology 23:733-737.
I<oval. T.M. and E.R. Kazmar. 1988. DNA double strand break repair in eukm3,otic cell lines having
different radiosensitivities. Radiat. Res. 113:268-277.
Koval. T,M, 1988. Enhanced recovery from ionizing radiation damage in a lepidopteran insect cell
Radiation Research 115:413-420.
Koval. T,M, and E.R. Kazmar. 1988. Eluting solution composition affects DNA double strand break
by filter elution. Int. J. Radiat. Biol. 54:739-747.
Koval. T.M. 1989. Split-dose and liquid-holding recovery following alkylating agent treatment of an
ionizing radiation resistant cell line. Abstracts of the 37th Annual Meeting of the Rod. Res.
See. p. 93.
Koval. T.M. 1989. Methods for determining the survival of cultured insect cells. Tissue Culture
Koval. T.M, D.L. Suppes, and J.M. Kramer. 1990. Heat resistance and thermotoleranee in a
insect cell line. Abstracts of the 38th Annual Meeting of ~he Radiation Research Society. p. 123.
Koval. T.M., D.L. Suppes, J.M. Kramer, and N.L. Dodge. 1990. Regulation of cell attachment and
of a lepidopteran cell line by medium pH. In Vitro Cellular and Developmental Biology 26:31A.
Koval. T.M., D.L. Suppes, J.M. Kramer, and N.L. Dodge. 1990. Isolation of x-ray- and
sensitive variants of a highly radioresistant eukaryotic cell line. Prec. Am. Assoc. Cancer
Koval. T,M, and D.L. Suppes. 1990. pH dependency of cell attaehment and grow that both clonal and
subculture densities of cultured lepidopteran cells. In Vitro Cell. and Dev. Biology 26:665-670.
Koval. T.M. 1991. Recovery from exposure to DNA-damaging chemicals in radiation resistant insect
Mutation Research 262:219-225.
Svingen, P.A., D.J. Schaid, D.L. Suppes, ~, and J.S. Kovaeh. 1991. Rat glioma model for
evaluation of radiosensitization. Proceedings of the American Association for Cancer Research
Koval, T,M. 1991. Radiation-inducible processes in invertebrate cells. In Vitro Cell. and Dev. Biol
Gutta, K.V., K. K. Wang, D.A. Ahlquist, T, M. KoTa!, G.L. Alexander, and M.R. Pittelkow. 1991. The
use of hematoporphyrin derivative as a radio~nsitizer in human eholangiocareinoma implanted in
mice. Gastroenterology 100(512]):A367.
Koval. T.M. 1991. Gamma-ray- and UV-sensltive stnfins of a radioresistant cell line: isolation and
sensitivity to other agents. Radiat. Res. 127:58-63.
Hayostek, C.J. and T.M~ Koval. 1991. Interactions of levamisole with radiation and/or 5-FU in human
tumor cells. Prec. 9th Int. Cong. Radiat. Res., p. 367.
Koval. T.M, and D.L. Suppes. 1991. Continuous low dose rate and chronic acute studies with resistant
insect cells. Prec. 9th Int. Cong. Rod. Res,, p. 230.
Kane, WJ., T.V. McCaffrey, T.D. Wang, and _T.,M, .Kgva!. 1992. Tl~e effect of previous fractionated
irradiation on the process of tissue expansion in the rabbit. Arch. Ore. Head Neck Surg. In Press.
Koval.~,lVl. and D.L. Suppes. 1992. Heat resistance and thennotolerance in an x-ray- and
line, Int. J. Radiat. Biol. In Press,
Schwartz, R,S., T.M. Koval, W.D. Edwards, A.R, Camrad, K,R. Bailey, K. Browne, R.E. Vlietstra, and
D,R. Holmes. 1991. The effect of external beam irradiation on neointimal hy~erplasia following
experimental coronaD" arlcry injury. Journal of the American College of Cardiology. In Press.
Koval. T,M. I991, Radiation-inducible processes in cultured Iepidop~eran cells. In M.J. Fraser,
Intcrnatl. Conf, Invertebrate and Fish Tim Cult. Tim Cult. Assc~:. Inic,, Columbia, MD., pp.