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S~F. S~rg " ~[~Piof~rofC~ I ~, I951 INST~UTION AND LOCATION DEGREE FIELD OF STUDY Mmqsachus~Rs Institute of Technology, Boston MA Harvard M~lical School, Boston MA B$ MD YEAR CONFERRED 1972 1976 ~,ESEARCH AND PROFESSIONAL EXPERIENCE: Con¢Iudin~l with present positien, llst, in chronological order, previous employment, experience. a,~o honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles and com. plete references to all publications during the past three years aml to representative earlier publications pertinent to this application. DO NOT EXCEED tWO ~AGES. 1980-1983 NIFI Traine~ in Endocrinology and Metabolism, Columbia University, College of Physicians & Surgeons, New York, NY 1983-1984 Visiting Fellow in Hormonal and Metabolic Diseases, Columbia University, College of Physicians & Surgeons, New York, NY 1983-1984 Instructor in Clinical Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY 1983-1991 Assistant Attending Physician, Presbyterian Hospital, New York, NY 1984-1987 Assistant Professor of Medicine, Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY 1987-1991 Assistant Professor of Medicine and Pharmacology, Columbia University, College of Physicians & Surgeon.st New York, NY 1991- Associate Attending Phystctan, Presbyterian Hospital, New York, NY 1991- Associate Professor of Clinical M~icine (in Pharmacology), Columbia University, College of Physicians & Surgeons, New York, NY HONORS Squibb Cardiovascular Research Fellowship 1984-86; Clinical Investigator Award, 1983-87; Phi Lambda Upsilon 1972; Phi Beta Kappa 1972. SELECTED PUBLICATIONS Cholst IN, Steinberg SF, Tropper PJ, Fox HE, Segre GV and Bilezildan JP: The Influence of Hypermagnesemia on Serum Calcium and Parathyroid Hormone Levels in Human Subjects. New Eng J Med 310:1221-1225, 1984. Steinberg SF, Drugge ED, Bilezildan JP and Robinson RB: Innervated Cardiac Myocytes Acquire a Pertussis Toxin-Specific Regulatory Protein Functionally Linked to the Alphal-Receptor. Science 230:1~6-188, 1985. Steinberg SF, Chow Y and Bilezikian JP: Regulation of Rat Heart Membrane Adenylate Cyclase by Magne:&~m and Marw~nes~. I Pharmacol Expt'l Ther 237:764-772, 1986, Stcinber:g SF, Chow Y and gilczikian JP: Stimukdorv &nd inhibitory Rcgulatic~l~ of Myocardial Aden) late Cycla:~e by Gpp(NH)p. Biochem Pharm 36:7:57-764, I9:37. Steinberg SF, Bilezikian JP and A1-Awqati Q: Fura-2 Fluorescence is I.~ca/izcd to Mito&ondria m C~dt,.tred Bo'.i~¢ AoEic Endothcli21 CelI~,. Am J Ph).siol 22:744-747, 19:~7. Russ S, Bilezikian JP a~id Robinson RB: An luexpc~si:'e Dual-E,:citatio~3 FF

Stem DM, Bre~: 3G, Steinberg SF, W'lner (3, Felix A, Heimer E and Nawroth PP: The Role of Endothelium in the Regulation of Blood Coagulation. Rous~eI Scienfifique Symposium, 1988. Rosen MR, Steinberg SF, Chow Y, Bilezildan IP and Danilo P: The Role of a Pertussis-Toxin Sensitive Protein in the Modulation of Canine Purkinje Fiber Automatieity. Cire Res 62:315-323, 1988. Horn EM, Corwin S£I, Steinberg S, Chow YK, Neuberg GW, Cannon PJ, Powers ER and Bilezikian JP: Reduced Lymphocyte Nueleotide Regulatory Proteins and Beta Adrenergie Reeeptors in Congestive Heart Failure and Reversal with Angiotensin Converting Enzyme Inhibitor Therapy. Circulation 78:1373-1379, 1988. Bilezikian IP, Steinberg SF, Horn EM, Robinson RB and Rosen l%IR: (3 Pmtein-Adrenergie Interactions in the Heart MoI Cell Biochem 82:5-I1, 1988. Brett JG, Steinberg SF, deGroot PG, Nawroth PP and Stem DM: Norepinephrine Down-Regulates the Activity of Protein S on Endothelial Cells. J Cell Biol 106:2109-2118, 1988. Steinberg SF, Kaplan LM, Inouye T, Zhang JF and Robinson RB: Alphal-Adrenergie Stimulation of 1,4,5-Inositol Trisphosphate Formation in Rat Ventricular Myoeytes. J Pharm Expt Therapeutics 250:1141-1148, 1989. Brett J, Gerlach H, Nawroth P, Steinberg SF, Godman t3 and Stem D: Tumor Necrosis Factor/Cacheetin Inereases Permeability of Endothelial Cell Monolayers by a Mechanism Involving Regulatory G Proteins. Journal of Experimental Medicine 169:1977-1991, 1989. Han HM, Robinson P.B, Bilezikian JP, Steinberg SF: Developmental Changes in Guanine Nueleotide Binding Proteins in the Alphal-adrenergie Receptor Complex in Rat Myocardinm. Cite Res 65:1763-1773, 1989. Malfatto G, Rosen TS, Steinberg SF, Ursell PC, Sun LS, Daniel S, Danilo P and Rosen MR: Sympathetic Neural Modulation of Cardiac Impulse Initiation and Repolarization in the Newborn Rat. Cire Res 66:427-437, 1990. Viamonte VM, Steinberg SF, Chow YK, Robinson RB and Rosen MR: Phospholipase C Modulates Automatieity of Canine Cardiac Purkinje Fibers. J Pharm Expt Therapeutics 252:886-893, 1990. Rosen MR, Steinberg SF and Danilo P: Develop}mental Changes in the Musearinie Stimulation of Canine Purkinje Fibers. J Pharm Expt Therapeutacs 254:356-361, 1990. del Balzo U, Rosen MR, Malfatto G, Kaplan LM and Steinberg SF: Specific Alph.al-Adrenergic Receptor Subtypes Modulate Cateholamine Induced Increases and Decreases m Ventricular Automaticity. Circ Res 67:1535-155I, 1990. Steinberg SF, Legato MJ, Rosen TS, Malfatto G and Roan MR: Beta Adrenergie Modulation of Cardiac Rhythm in a Rat Model of Altered Sympathetic Neural Development. J Mol Cell Card ~-x7 57 199t. Steinberg SF, Robin_~on RB, Licberman HB, Stern DM and Rosen MR: Thrombin Modulatc5 Pho.;?i,oi~ositide Hydrol)sis, Cytosolic Calcium and 6:'3: I216-I229. 199l. Lee Llcdulatcs Rc?..,larizat~on in Canine Purkinje Fibers. J l:'h2.rm E,:p: Tl~cmpcutics (In PresaL 199I. 50597030