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BIOGRAPHICAL SKETCH Murli },~mnohar EDUCATION l~e~i, n w'itl~ b~¢ca!~ur~ate or other inili~] ~mfessi~nal educ~tio,~, such as nursing_, and inclu¢9 Y~R INSTI~TION AND LOCATION DEGREE CONFERRED ~jab ~ic~t~al U~v. (~a) B.V.Se. 1968 H~a A~ic~t~al g~iv. ( ~dia ) M.S. 1970 U~versi~ of Niscons~, ~dison Ph.D. 1978 FOSI~ON T~LE j E~RTHDATE fMo_ DaD Professor: Cardiopulmona~ Physiolo~7 10ct. 3, 19~7 FIELD OF STUDY Veteriuary ~edicine Cardiac SurEery Coronary Cir cula~ion RESEARCH AND FROFESS1ONAL EXFERIENCE: Concludin~ with present position, list, in chronological order, previous emgCoyment, experience. and ~onors. Include present membership on any Federal Government public advisory committee, List, in chronological on3m, the titles and com. ple~e references to all publications dudng the past three years and to representative earlier publications perlinent to this aplMication. DO NOT EXCEED TWO PAGES. F_/~PLOY~N'T: 1. University of Wisconsin, Madison, WI (197&-1978): Research Associate. 2. University of Illinois as Urbana-Champaign, IL (1979-1981): Assistant Professors (1982-1987): Associate Professor~ (1987-present): Professor. AWARDS: i. College of Veterinary ~edicine Beecham Award for Research Excellence (1986). 0THOR SCIENTIFIC ACTIVITIES: - ~ember editorial advisory board of the ~nerican Journal of Veterinary Research (1982-1987) ~ud Veterinary Research Communications (1985-present). PUBLICATIONS: Ple~se see next page.

Z Z Z I. Z z REPRESENTATIVE PUBLICATIONS OF THE PRINCIPAL INVESTIGATOR: Manohar M, Bisgard GE, Bullard V, et al: ~Wocardial perfusion and function during acute right ventricular systolic hypertension in ponies. Am J Ph~siol 235:H628-H636, 1978. Hanohar M, Bis~ard BE, Bullard V, et al: Regional myocardial blood flow an~ myocardial function during acute right ventricular pressure overload in calves. Circulation Res 44:531-539, 1979. 3. Manohar M, Bisgard GE, Bullard V, et al: Blood Flow in the hypertrophied right ventricular myocardium of unanesthetized ponies. Am J Physiol 240:H881-H8BS, 1981. Manohar M, Thurmon JC, Devous MD, et al: Regional myocardial blood Flow anc coronary vascular reserve in unanesthetized young calves with severe concentric right ventricular hypertrophy. Circulation Res 48:785-796, 1981. Manohar M, Parks C, Busch M, et al: Regional myocardial blood Flow and coronar~ vascular reserve in unanesthetized young calves exposed to a simulated altitude of 3500 m For 8-10 weeks. Circulation Res 50:714-726, 1982. 6. Parks C, Manohar M: Transmural coronary vasodilator reserve and flow distributior during severe exercise in ponies. J Appl Physiol 54:1641-1652, 1983. 7. Parks C. Manohar M: Distribution of blood flow during moderBte and strenuou~ exercise in ponies (EQuus caballus). Am J Vet Res 44:1861-1866, 1983. Parks C, Manohar M, Lundeen G: Regional myocardial blood Flow and coronar~ vascular reserve in unanesthetized ponies during pacing induced ventricular tachycardia. 3 Surg Res 35:119-131, 1983. Manohar M, Parks C: Transmural coronary vasodilator reserve in ponies at rest anc during maximal exercise. In Equine Exercise Physiology (Snow DH, Persson SGB, Rose RJ, eds). Granta Editions, Cambridge (UK), 19B3, pp. 91-I04. lO. Parks C. Manohar M: Blood-gas tensions and acid-base status in ponies durin~ treadmill exercise. Am J Vet Res 45:15-19, 1984. II. Manohar M, Parks C: Regional distribution of brain and myocardial perfusion if swine while awake and during l.O and 1.5 MAC isoflurane anesthesia producec without or with 50 percent nitrous oxide. Cardiovasc Res 18:344-353, 19B4. 12. Manohar M, Parks C: Porcine systemic and regional organ blood flow during l.O ant 1.5 minimum alveolar concentrations of sevoflurane anesthesia without and with 5C percent nitrous oxide. J Pharmacol Exptl Therap 231:640-648, 1984. 13. Manohar M: Transmural coronary vasodilator reserve, and Flow distribution durin~ tachycardia in conscious young swine with right ventricular hypertrophy. Cardiovasc Res 19:104-I12, 1985. 14. 15. Manohar M: Blood Flow to the respiratory and limb muscles, and abdominal organ~ during ma×i~a| exercise in ponies. J Phvsiol (London) 377:25-35, 1986. ~anohar M: VasodilaZor reserve in tThe-respira~orw muscles during ~axim~l exercis~ in ponies. J ~ppl Physiol 60:1571-~577, 198G. 16. Manohar H: Regional brain blood flo~ and 02 deliv~r~ during ~ver~ ~xertion i~ the pony. Respir Physiol 64:339-349, 1986. 50571874

Z Z 0 Z 0 17. 18. 19. 20. 21. 22. 23. GoeZz TE, ~nohar M: Right heart and esophag~zl (plsural) pressures of ponies during strenuous exertion before and after furose~ide administration. A~ J Vet Res 47:270-276, 1986. Manohar M: Regional brain blood flow and cerebral cortical 02 consumption durin~ sevoflurane anesthesia. J Cardiovasc Pharmacol 8:1268-1275, 1986. Manohar M: Blood flow to the respiratory muscles during maximal exertion ponies with laryngeal hemiplegia. J Appl Physiol 62:229-237, 1987. Manohar M, Gustafson R, Nganwa D: Skeletal muscle perfusion during prolonged 2.03% end-tidal isoflurane-O2 anesthesia in isocapnic ponies. Am J Vet Res 48:946-951, 1987. Manohar M, Gustafson R, Goetz TE, Nganwa D: Systemic distribution of blood flo~ in ponies during 1.45, 1.96 and 2.39% end-tidal isoflurane-O2 anesthesia. Am Z Vet Res 48:1504-1510, 19B7. Manohar M, Goetz TE, Holste LC, Nganwa D: Diaphragmatic 02 and lactate extractioF during submaximal and maximal exertion in ponies. J Appl Physiol, 64:in press, IgBB. Manohar M: Costal vs. crural diaphragmatic blood Flow of ponies during submaxima~ and maximal exercise. J Appl Physiol, accepted For publication, IgBB. 0007