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TI:I]D OOI~NOIL FOR []~OB~kCCO I~ESI~.~RoH-U.B.A., INC. HARMON C. ~0ALLISTER. PH.D- April 10, 1995 Dan Canaani, Ph.D. Tel Aviv University Dept. of Biochemistry Ramat Aviv 69978 Israel, Re: 5582 Dear Dr. Canaani: Your recent inquiry concerning support by this Council of a proposed research project has been considered by the Executive Committee of the Scientific Advisory Board. The Committee expressed interest in examining a more detailed plan of the proposed investigations. I take pleasure in enclosing the necessary forms and relevant literature pertaining to the filing of a formal application. The next .de'/tdline for submitting proposals is .May 31, 1995. You understand, of course, that no commitment is implied at this time concerning the final action of our full Scientific Advisory Board on the complete proposal. Sinqerely yours, . ] Harmon McAllister HCB,Uslmla 40008952

THE COUNCIL I~OR TOBACCO RESEARCH SUPPORT|NO I~IOMEDICAL INVEST|OATION GEOP.OE A. HA$HIM, PH.D. ASSOCIATE RESEARCH DIRECTOR PRF_J.,I~NARY APPLICATION BVALUATION 900 THXRD Avenue "~-=- NEW YoRI~, N.Y. (212) 421-8885 Preliminary Application Number: 558~ Applicant's Name mad Degree(s): Inst~tu.lion: Title: [~] To~ ~Top 20 % ~ Top 30% TEL AVIV UNIVERSITY A NATURAL OCCURING BJMAN ANTI.SENSE P, NA- A REPRESSOR OF CELLULAR P, ADIORESISTANCE Please review this application and indicate your scoring below. : A return envelope is provided for your convenience. We expect the top 30% of Preliminary Applications will be encouraged to submit Full Applications. (~3 Top 40% Top • [~ Below/~0% E.cviewer's =omment~: . Copies to: pa-rey2.d~= rcvO7.11.94 40008953

APPLICATION EVALU/kTION iLB: Preliminary Applieation Numbor: 558~,/ Applicant's Name and Degree(s): Institu.tion: Title: TEL AVIV UNIVERSITY A REPRESSOR 8F CELLULAR RADIORESIST~CE 1. Please review this application and indicate your scoring below. ~ A return envelol~ is provided for your convenience. 2. We ex.peet the top 30% of Pzeliminary Applieations will be encouraged to submit l~ull Applications. Top 10% Top 20% Top 30%" Reviewer's comments: • Top 40% Top 50%.: • REDACTED 40008954

SUI>PO~.TINO BIOMEDICA~ IHVEST!OATIOH GBORO~- A. HASH|M, PH.D. • ~SSOClATE RESEAP.CH DIRBCTOR PRELIMINARY APPLICATION EVALUATION Date: FEB. 16, 1995 900 THIRD AV~HUE"~-~- NEW YORK, N.Y. 1002-:2. (212) 421-Z885 -.. Reviewer 1: [~. BREi~;~I1 Reviewer 2: DR. JOKLIK P,.E: P~eliminary Applieation Number: 5582 Applicant's Name mad Degree(s): Institu.tion: Title: DAN CANAANI, PH.D. TEL AVIV UNIVERSITY A NATURAL OCCURING HL~4AN ANTISENSE RNA- A REPRESSOR OF CELLULAR RADIORESISTANCE 1. Please review this application and indicate your scoring below. : A return envelope is provided for your convenience. 2. We expect the top 30% of Preliminary Applications will be encouraged to submit Full Applications. Top 10% {:1 Top 40% Top 20% [~I Top 50%... • Top 30%" ~ Belo~v 50% Rcviewer's comments: - Date: Copies to: Drs. Eisenberg, Ford, HashL.n, McAllJstcr p~t-revZ.do~" rev07.11.94 Signature: 40008955