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BIOGRAPHICAL SKETCH NAME J P(~ITiON TITLE Elias Balbinder I Research Professor EDUCATION (Be~in with bacca~ureate or other (nit,'a! professional educa~.~n, such as nursing, ar, d indude postdoct~rM t~a~,Yng.) INSnTUTIONANDLOCA~ON Univ. of Michigan, Ann Arbor, M[ Indiana Univ., Bloomington, IN Cargegie Inst., Cold Spg. Herb., NY" Univ. of Calif., San Diego, CA DEGREE Ph.D. Postdoc Postdoc YEAR CONFERRED 1957 19,57-60 1960-63 FIELD OF STUDY Zoolog~ Zoology (Genetics) Bacterial Genetics Biochemistry RESEARCH AND PROFESS~NAL EXPERIENCE: Co~Iudi~ ~th present pos~i~, I~t. in ~m~logica] mde~ we~s eml~oymen~ ex~nce. ~ honor. Key pe~onnel i~lude the ~ncipal inve~ig~or and any other ind'NiduaJs w~ participate ~ ~e scie~ d~elopme~ ~ ~ecut~ of the ~oject. Key pe~onnel ~pical~ ~ |~lude ~ in(ividua~ with doctoral or other ~o~ssio~l degree, but ~ some projects ~11 include ino-widu~s at the modem ~ baccalaure=e le~! Wovided they ~n~bute in a ~n~e way to the scientific ~velopment or execution ~ the project. I~ we~ membem~p on any Federal Government pu~ advlso~ ~mm~ee. U~. in ~m~looical mde~ the ~l~s, a~ a~ho~s, and ~rnl~e~ references ~ all ~¢atJo~ dud~ the pa= three yearn and ~ m~ese~a0ve earlier publications ~ ~ t~s application. DO NOT EXCEED TWO PAGE~ 1963-67 Assistant Professor of Genetics, Dept. of Bacteriology and Botany, Syracuse University, Syracuse, NY. 1967-71 Associate Professor of Genetics, Dept. of Bacteriology and Botany, Syracuse University, Syracuse, NY. ]971-76 Professor of Genetics, Dept. of Biology, Syracuse University, Syracuse, NY. 1976-82 Head, Laboratory of Genetics and Carcinogensis, AMC Cancer Research Center and Hospital, Lakewood, Colorado. 1982-93 Adjunct Professor, Dept. of Biochem/Biophys/Genetics, Univecsity of Colorado Health Sciences Center, Denver, Colorado 1993- Research Professor, Dept. of Biochem/Biophys/Genetics, University of Colorado Health Sciences Center, Denver, Colorado Awards, Fellowships, etc. 1960-63 2/'63-8/63 2/70-8/70 1977-79 B/el-g/el Postdoctoral Research Fellow, American Cancer Society - Laboratory of Dr. David M. Bonner, University of California, LaJolla, California. Fulbright-Hays Award to conduct research at the Department of Biology, Univ.of Buenos Aires., Argentina. Special Fellowship of the National Institute of Health. To conduct research in the laboratory of Dr. Aizo Matsushiro, Osaka University, Osaka, Japan. Member, National Science Foundation Panel on Genetic Biology. Recipient of Fulbright-Hays Award and Visiting Professor, Univ. of Los Andes, Bogota, Colombia. To teach course in Molecular Genetics. Publication~..during the past three veals o Balbinder, E. and Waldren, C. A review of DNA metabolism in E. coll. Cell Biology Reviews 25:105-155 (1991). Balbinder, E.,Coll,B.,Hutchinson,J.,Bianchi,A.S. and Groman,¥., Wheeler,K.A. and Heyer,M. Participation of the SOS system in producing deletions in ~.colt plasmids. Hutn. Res. 2B6:253-265 (1993). Balbinder,E. Rultiple pathways for deletions in gscherichia col1. Mut. Res. 299:193-209(lg93). Levy,H.S., Ba]binde~,E.and Nagel,R. Effect of mutations in SOS genes on UV- induced precise excision of Tnl0 in ~cherichia col~. Rut. Res.293:2¢l-~47 (1993). PHS 3.~8 (Rev. 9,31) (Fcnn Pa3e 6) Page FF 40000080

Principal Investigator Representative pertinent earlier Dubli¢~tions o o 10. 11. 12. 13. 14. Callahan,R.and Ba]binder,E. Tryptophan operon: Structura] gene ~utation creat|ng "promoter" and leading to 5-~ethylLryptophan dependence. Science 168:1586-1589 (1970)o LaSco]ea, L.J., and Ba]binder, E. Restoration of phosphoribosyltransferase acLiv|L~ b~ partially deleting the ~ 9ene of the tryptophan eperon of ~otyOhieurium. ~. BaCLo ]1~: 877-885 (1972). Racrina,F.L. and Balbinder,E. P]asm~d associated functions of a stable F'~ac. ~. Bact. 1~3:1183-119! (1973). Racrina, FoL., Ba]bindec, E.o and Basse|, A]ix, Ho]eculac characterization of a stable F'~acplasmtd. Biochem. & B~ophys. Res. Comm. 54:737-743 (1973). Ca]]ahan, R. ]I[, Doo]ey,H.H., and Ba]binder, E. A~uLation to S-methy]tryptophan dependence in the Lryptephan (Lrp) operon of Salmonella typhtmu~]ue. []. Studies of 5-meLhy]tryptophan-dependent mutants and their revertants. No]ec. Gen. Genet. 165:129-143 (1978). La$co]ea, L.~., Doo]ey, M.M., Torget, R., and Ba]binder, E. A mutation to 5-rnethy|t~ptophan dependence tn the ~ opecon of Salmonella tvphtmur~u~. I[~. Correlation between phenotype and the properties of the second enzyme for tcyptophan biosynthesis in a 5-methy]tryptophan dependent mutant and several 5-methy]tryptophan-independent revectants. Mo]ec. 6en. Genet. 165:145-153 (1978). Ange]osanto, F.A., Torget,R., and Ba]binder, E. A mutation to a 5-methy]tryptophan dependence in the ~D operon of Salmone]]a typh~muriu~. ~V. ~so]ation and characterization of t~JZ promoter mutations. Holec. Gen. Genet. 165: lSS-166 (1978). Doo]ey, ~. and Ba]btnde~) E. Differences between the AnLhrani~ate-5-phosphoribosy] pyrophospate phosphoribosy]transferases of Salmonella ~ strains LTZ and LTT. ~.Gen. Hicrobio~. 112:]71-179 (1979). Ba]btnder, E., Reich, C.I., Shugarts, D., Keogh, J., Fibiger, R., Jones, T., and Banks, A. Relative muLagenicity of some urina~ymetabolites of the antitumor drug cyclophosphamide. Cancer Research 41:2967-2972 (1981). Balbinder, E., Kerry, D. and Reich, C.I. Deletion induction in bacteria. I. The role of ~utagens and cellular error-prone repair. Hut.Res. ]]2:147-168 (1983). Balbinder, E., Stick, S.H. and ShaPma, O.K. Complex effects of retinol on the metabolic activation of 2-am]nof]uorene. Env. Nut. ~: 665-678 (1983) Balbinder, E. and Kerry O. A new strain of Salmonella tv~hvmuriu~ reverted by mitomyc|n C and N-methyloN-nitro-N-nitrosoguanidine; a possib]e universal tester for Inutagenic compounds. Hut. Reso 130:315-320 (1984)o Balb~nder, E. Use of pre-designed p]asmids to study de]etions: strategies for dealing with a complex woblem.Chapter 40, pp°378-391-ASH, ~ash~ngton, D.C. In DNA Replication and Hutagenests. Eds.R.E.Hoses and ~.C.Summers (1988). Balbinder,E.,HacVean,C. and ~illiams,R.E. Overlaping direct repeats stimu]ate deletions on specially designed derivatives of plasmid pBR325 ~n E~L]_~. Hut.Res. 214:233-252 (1989). Page 31 40000081

CURREN2~Y ACTIVE GtLANTS, CONTRACI'S and OTHER. SOURCES of FONDS List financial support (direct costs, erda,) from all sources, includin$ own institution. Title of Project Regulation of synthesis se- cretion of salivary proteins. (co-PI; K.N.Prasad,PI) Construction of E.coli strail useful for stabilizing un- clonable DNA sequences (con- tract) Sources (giv~ graat numbers) NIH- ROI DE09589 S Life Tec Inc. Gaithersbu MD Total Value of Grant costs) 1,278,155 (5 ys.) $12,000 =g Current Annual Amount Available to You $ 18,000 (22% salaryl $12,000 Date of Termination of Grant 9-30-94 (my part.) 9-30-94 Identify and describe any overlap of this application with the above grants: NO overlap- There has been no funding for the project in this application since 1992. Indicate the total annual funds available to you this year for all research projects under your supervision. 12,000 PENDING OR PLANNED . Title of Project Construction of E.coli strains .... (see above) (contract) (pending) S 0urces (give ~t numbers) Life Teeh, InC. Identify and describe any overlap of this Total Value of Grant (di, ct co t ) $ 50,000 al~plication with Avg. Annual Amount Availablo to You 50,000 Total Duration (give inclusive dates) 1 year (I0-i-94 thro 9-30-95) the above project. NO overlap- Application to NSP and NIH of a prposal to study X-ray-induced deletions planned for some time this year depending on completion of preliminary experiments. tgh 40000082