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RESEARCH AND DEVELOPMENT, NEUCHATEL - QUARTERLY REPORT DIVISION . RESEARCH! SUBJECT TITLE HYDRA, ETS PERIOD COVERED JULY - SEPTEMBER1988' WRITTEN BY Gerber-C. (CAG) KEYWORDS . ets, rsp, nicotine, solanesol, sfc, tno PROJECT HYDRA Objective Obtain an analytical data-base on ETS through indoor air monitoring experiments. Test the analytical methods through work with other laboratories. Stattus - SFC instrumentation A Carlo Erba SFC 3&00 supercritical fluid chromatograph was receivedi(on lease) early in September. The instrument is now operational. Pending delivery of a suitable coliumnifor solanesol analysis, and as a support to QA, a method is being developed for polyethylene glycol. - Carbonimonoxide detectors A Hioriba APMA 350E NDIR analyzer for carbon mono.:ide monitoring was received in place of the Dasibi 30108 which was sent to:us pending delivery of the final instrumentation and was four.dl unstable. The sensors were changed on both PASS units and their response is being regularly monitored. - Solanesol analysis The existing method for solanesol analysis in RSP condensate was modified onithe basis of the publication by Odgen et al. [1]. The GC conditions and the extraction solvent were changed. Under these conditions, analysis of standards gave good results. However, anlirrterference with the internal standard suggested in this paper was observed for filter extracts.

RESEARCH AND~DEVELOPMENT, NEUCHATEL - QUARTERLY REPORT PROJECT ETS Objective Support S&T inithe organization of sub-contracted studies on ETS. Status Work started, in collaborationiwith S&T, onia project of ETS real-life monitoring to be sub-contracted to an external laboratory in Belgium. Additional experiments were performed in Holland in the TNO facility in order to test their analytical method'ology and equipment (nicotine, RSP and carbon monoxide monitoring,using portable samplers). The instrumentation~developed by TNO was found suitable for the monitoring of ETS in air-liners, and recommendations were made to change some points in their analytical techniques and laboratory practices [2]. SUPPORT TO OTHER GROUPS Upon req,uest of Quality Assurance, we made some analyses of the air inside the smoking laboratory. Nicotine, RSP (using the TSI 5500 and'by filter gravimetry), ammonia, carbon and~nitrogen monoxides and nitrogen dioxide were monitored at different locations over a 3'-d'ay period [3]. Two smoking sessions were performed inn an office of the R&D building at a high ETS level (50 ppm CO) inlorder to monitor the non-volatile nitrosamine concentration as a function of time. Results were handed over to the SS-study group as a support to project TASSO. PLANS Support will be given to S&T for field samplings and for co-operation with external laboratories upon their request. Solanesol analysis technique will be applied to all collected samplles. A method will be established for the determination of trace amounts of volatile organic compounds, especially benzene and ethylene, in indoor air. New analytical methods using supercritical fluid chromatography will be designed and assessed (PEG, solanesol andipesticides).

RESEARCH'.AND DEVELOPMENT, NEUCHATEL - QUARTERLY REPORT REFERENCES [1], Odgen-M.W. and Maiolo-R.C.,, J. HRC & CC, 11 (1988)', 341-3'43. [2]' Memo from Piade-J.J'. to Reif-H!., Comparison of TNO sampling case to RJR PASS, August 10, 1988. [3] Memo from Gerber-C. to Senehi-F., Analyses d'air au laboratoire de fumage, September 30, 198'8.