Tobacco Documents Online

PRIVILEGED ATTORNEY WORK PRODUCT CTR SPECIAL PROJECTS 77-84 ~AO PROJECTS - Dr. L.G.5. Rao - FUNDED THROUGH SPECIAL ACCT 4 77-84 1. SUBJECT: Relationshlp of maternal nutrition to poor fetal outcome (i.e. low birthweight, birth defects, spontaneous abortion, stillborns.) 77-84 CONCLUSION: Low proteln intake (poor nutrition) associated with poor fetal outcome more than smoking habits. (NUTRITIONAL HYPOTHESIS) *NOTE: Dr. L.G.S. Rao also received Special Account 4 money for testifying in the Hatch- Packwood, Waxman hearings. SUBJECT: Relationship of sex hormones to lung cancer in females. CONCLU$~QNS: Women with lung cancer showed higher levels of 17-hydroxycortisosteroids. 1977 3. SUBJECT: Using estrogen/creatinine ratio as a predictor of fetal health Dr. Rao proposed that this ratio be used to study the effects of smoking and nutrition on fetal outcome, but doesn't look like this project was ever funded. 1978 4. SUBJECT: Relationship between stress (as measured through adrenal hormones) and coronary heart disease. (Proposal accepted.) CONCLUSIONS: (Cannot find results.) RILEY PROJECTS 81-83 INVESTIGATORS: Santisteban Vernon Riley, Darrel Spackman, George A. SUBJECT: The relationship between stress and cancer using mice. RESULTS: Inducing stress in mice by spinning them in a cage caused cancer to spread more quickly than in mice that weren't spun. Tumor growth rate faster In stressed mice. *NOTE: Project was funded for an additional year under .Spackman after Dr. Riley's death in March, 1982. -I-

PRIVILEGED ATTOKNET WORK PRODUCT ROBERTS PROJECT - Dr. Jay Roberts (His project was part of Puglia's) 79-82 SUBJECT: Components research on the effect of nlcotlne on cardiovascular response in rats. Studied acute and chronic effects using animal (rodent) inhalatlon and by removing the heart and exposing it to nicotine. RESULTS: Seem to suggest that the hear~ adapts to nicotine effects. Ventricular tachycardia did not occur in experimental group. PUGLIA PROJECT - Dr. Charles Puglia worked along with Dr. Jay Roberts. 79-81 SUBJECT: Adaptation of rat lung to cigarette smoke. Focus is on showing that the lung has defense mechanisms to oxident components (nitrogen dioxide, peroxides,and hydroperoxides). RESULTS: The "bad" effects of cigarette smoke (i.e. weight loss) seemed to decrease as the experiment went on, suggesting an adaptation to cigarette smoke was taking place in the rats. ROTHSCHILD PROJECT: Cohen Dr. Henry Rothschild, Sherrolyn Weed, I rwln 77-84 SUBJECT: The unusually high incidence of lung cancer mortality in Louislana. Conducts interviews with relatives of deceased to determine a link between lung cancer and genetic/environmental factors. Study was retrospective epidemiology. (May have been funded through a CTR grant durlng some of this time.) 77-79 RESQLTS: Determined that a link between sugar cane farming and high lung cancer incidence in LA existed. No conclusion on a genetic link. NOTE: He also testified at Hatch-Packwood, Waxman Hearings and probably received Special Acct 4 Money. RUSSEK PROJECTS - Funded through 5pecial Acct 4 -2-

PRIVILEGED ATTORNEY WORK PRODUCT INVESTIGATORS: Drs. Henry and Linda Russek (Father and daughter) 84-85 i. SUBJECT: Relationship between psychological factors and disease. Specifically, they hypothesize that failure to master stress is an indicator of future ill health (coronary heart dlsease). Henry and Linda Russek have long investigated the link between stress and heart disease using prospective epidemiological studies. Have also found that smoking may be an effective means of coping with stress. RESULTS: (Proposal approved, but no results given.) 79-80 2. SUBJECT: Techniques for dealing with stress. Russek's evaluated different behavioral therapies for coping with stress (meditation, biofeedback, exercise and cigarette smoking) among male smokers. RESULTS: Proposal approved, and expected results to show that cigarette smoking is the best mechanism for smokers to cope with stress. Expect to show benefits of smoking (i.e. to reduce risk of stress-related heart disease.) SCHRAUZER PROJECT 81-82 i. SUBJECT: Investigation of the levels of selenium (trace element with anti-carcinogenic properties) in tobacco products and of whether selenium is present in tobacco smoke. RESULTS: After one year of a proposed 2 year project, Dr. Schrauzer concluded he had done as much work as was possible in the area, and research stopped. 83-85 2. SUBJECT: Dr. Schauzer proposed to test the various etiological models of lung cancer by explorlng lung cancer data around the world. (No results found for this project.) *NOTE: Dr. 5chrauzer also testified in hearings re: Comprehensive Smoking Preventlon Act of 1982. SALVAGGIO/LEHRER PROJECT - All studies deal with rebuttlng contention that ETS aggravates allergies. -3-

PRIVILEGED ATTORNEY WORK PRODUCT INVESTIGATORS: Drs. John Salvaggio and Samuel B. Lehrer 83-87 I. SUBJECT: Determining whether people who claim to be "smoke sensitive" (allergic to smoke) really do show skin test reactlons and decline in lung function from allergens found in smoke. (HUMAN CLINICAL STUDY Want to measure objective reactions to ETS. RESQLT~: Challenge studies showed that exposure to cigarette smoke did not cause a significant decl~ne in lung function among "smoke sensitive" individuals. Found that ETS did impair lung function in asthmatics. 80-82 2. ~UBJECT: Identifying the allergens in tobacco smoke (Components research) RESULTS: Preliminary clinical trails suggest that there are little, if any, human allergens in tobacco smoke. 76-79 3. ~UBJECT: To znvestigate which components in tobacco and tobacco smoke act as allergens in rats and mice. (Injected animals with smoke extract.) RESULTS: There are components in tobacco smoke which clearly have ~mmunogenic and allergenic potential in rabbits and mice. -4-