Tobacco Documents Online

PRIVILEGED AND CONFIDENTIAL ATTOKNET WORK PRODUCT 1052 NICOTINE: - particulate phase constituent - narcotic found in tobacco - agricultural insecticide - LD50 orally to rats is 50-60 mg/kg 1053 NITRATEfs) (NO31: - particulate phase constituent - additive which decreases BaP delivery but increases tar delivery thus increasing NO delivery. NO transforms into nitrosamines which are carcinogenic. - denitrification by actron filter became popular to decrease the nitrosamine delivery. 1054 NITRILE(s), ACETONITRILE, et al: R-CH-NH nitrile H3C-CH=NH - particulate phase constituent - LD50 orally to rats is 130 mg/kg acetonitrile or methyl cyanide 1055 NITROGEN OXIDES, NO, NO2, NOx: - gas phase constituents - suspected mucus flow inhibitor - toxic agent -ii-

PRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT 1056 NITROSAMINES: H2N-N=0 H3C-CH2-NH-N=0 (CH3)2-N-N=0 nitrosamine N-nitrosodiethylamine (NDMA) N-Nitrosodiumethyamine - gas phase or condensate constituent - some are suspecte4 lung carcinogens by EPA - nonvolatile nitrosamines include nit~osonornicotine (NNN), Ditrosopeyr~olidine (NPYR), n~trosanatabine (NAT), 4-1N-methy1-N-nitrosoamino}-~-)~-pyridyl)-l-butanon~ (NNK) - nonvolatile nitroSzmines allegedly not filtered out by cellulose acetate filter - volatile ones removed by filter, claimed (but not proven) nonvolatile ones cannot be filtered - TSNA is tobacco specific nitrosamines 1057 NUTMEG: (code: BRALOR, NILIND) - flavor additive 1058 ORANGE: (code: GINFIZ, ADMETA) - flavor additive - potentially hazardous 1059 OZONE: - gas phase constituent 1060 PENAR, M~THOPRENE, ALTOZID: - weevil control pesticide - residues may be on tobacco 1061 PHENOL(s1: - particulate phase constituent - disinfectant - suspected mucus flow inhibitor phenol or carbolic acid -12-

PRIVILEGED AND CONFIDENTI~KL ATTORNET WORK PRODUCT 1062 PHOSPHATE(s1: (code: QUELAR) - paper additive, burn retardant 1063 POLONIUM 210, Po210, 210 Ph: - particulate phase constituent - radioactive fertilizer, residue - sticks to trichomes (sticky underside) of tobacco leaf and is converted to polonium or lead 210. - when inhaled it may impinge on the bifurcation of the tracheobronchial tree and lead to lung cancer - radiation hazard 1064 POLYCYCLIC AROMATIC HYDROCARBONS, PAH, N-PAH, HYDROCARBONS: - particulate phase constituent - suspected lung carcinogens - general class of multiple aromatic c~mpounds including those containing D~trogen - e.g. anthracenes {code 1006) aza-arenes (code 1009), benzoperlene [code 1012), carbazoles (code 1017), ch~-ysenes (code 19~), dibenzacridines (code 1035), fluo~anthenes (code Iq37~, harmanes (code 1041), indoles (code 1045), pyr~s (code 1067) 1065 PRUNE CONCENTIO.A2E: - flavor additive (code: OUTS/N, PRONUS) 1066 PYRAZINES~s): (code: TERRAN) - particular phase constituent) - polycyclic aromatic hydrDcarbon - suspected lung carcinogen -13-

PRIVILEGED ~D CONTIDENTIA~ ATTORNEY WORK PRODUCT 1067 PYRENE(s).: - particulate phase constituent - polycyclic aromatic hydrocarbon - suspected lung carcinogen 1068 1069 QUINOLINE$: - particulate phase constituent - suspected carcinogens RADON (RADIOACTIVIty}: - statistical synergistic effect with smoking for lung cancer 1070 SAGE: (code: - flavor additive - possibly hazardous 1071 ST. JOHN'S BREAD: BRANEW, SILNEW, CANAGO, QUIKEX) (code: FRALDO, LIMATO, MADMART) - flavor additive - also called LOCUST BEAN GUM or CAROB BEAN 1072 STYRAX: 1073 SUGAR: (code: AVALADE, QUASER) - casing/humectant additive - potentially hazardous -14-

pRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT 1074 TAR, TPM, PARTICULATE MATTER: - the portion of cigarette smoke trapped by a cambridge filter 1075 TONKA BEANS: - flavor additive - contains COUMARIN (code: EFANGUS) 1076 URANIUM: - radioactive element - statistically synergistic effect with smoking for lung cancer 1077 0 NH2-C-0-CH2-CH3 - gas phase constituent - suspected carcinogen - LD IV in rabbits in 2.0 g/kg 1078 VALERIAN ROOT : - flavor additive (code: FRALIP) 1079 VANILLIN, VANILLA BEANS: (code: LASSEN, MOSTING, VERINO, ONAVET) - flavor additive 1080 VINTL CHLORIDE: - gas phase constituent - suspected carcinogen CH2=CH-C1 1081 WALNUT: - flavor additive -15-

PRIVILEGED AND CONFIDENTIAL ATTORNEZ WORK PRODUCT 1082 1083 1084 6-METHTL ~3ENZOPTRONE : I-MENTHONE ACETANISOLE ACETOIN ACETOPHENONE* ACETYL-5-METHYLFURAN, ACETYLINE ACETYLPYRIDINE, 2- ACETYLPYRIDINE, 3- ACETYLTHIAZOLE, 2- ALAN INE, BETA- ALFALFA, EXTRACT ALLYL HEXANDATE ALLYL ISOTHIOCYANATE ALLYLANISOL* ALMONDS, BITTER, OIL* AMBER OIL (Amyls)* AMBERGRIS* AMBRETTOLIDE AMBROX AMINOBIPHENYL AMMONIUM CARBONATE* AMMONIUM SULFATE* AMYL ACETATE* AMYL ALCOHOL AMYL BENZOATE* AMYL BUTYRATE* AMYL CINNAMATE AMYL FOF4~ATE* AMYL HEXANOATE* AMYL ISOVALERATE* AMYL OCTANOATE* AMYL PHENYLACETATE* AMYL SALICYLATE* AMYL VALERATE* AMYLASE-A ANETHOLE* ANGELICA ROOT* - ANILINE ANISE* ANISE, OIL* ANISE, STAR, OIL 2-. possible carcinogen -16-

PRIVILEGED AND CONFIDENTIAL A_'TORNE~ WORK PRODUCT ANISYL ACETATE* A/~ISYLPHENYL ACETATE ~PPLE* APRICOT* ARACHIS* ARRACK ASPARTIC ACID, L- BANANA* BI~SIL, OIL BAY LEAVES, WEST INDIAN BAY OIL* B-BROMOSTYRENE* B-C_ARYOPHYLLENE BEAVER CASTORS BENTONITE* BENZOIN BENZOIN GUM BENZOIN, RESIN BENZYL ACETATE* BENZYL ALCOHOL* BENZYL BENZOATE* BENZYL BUTYRATE* BENZYL CINNAMATE* BENZYL FOKMATE* BENZYL ISOBUTYRATE* BENZYL PHENYLACETATE* BENZYL PROPIONATE* BERG~MOT OIL* BIRCH, SWEET, OIL BIRCH TAR, OIL BLACKCUKRENT* BORONIA, ABSOLUTE BUCHU LEAVES, OIL BUTANE - 1,3 - DIOL* BUTANONE* BUTTER DERIVATIVES BUTYL AC*ETATE BUTYL ALCOHOL BUTYL BUTYP~ATE* BUTYL BUTYRYLLACTATE BUTYL CINNAMATE BUTYL PHENYLACETATE* BUTYLCYCLOHEXANONE, 2-SEC- BUTYLIDENEPHTH~kLIDE, 3- CAD INENE* CAJEFUT OIL* CA/~CIUM CARBONATE* CALCIUM CHLORIDE* CAMPHOR OIL* CARAMEL* (Alleged carcinogenic precursor) CARAWAY OIL* CARBON DIOXIDE, CO2 CARBOXYMETHYLCELLULOSE (CMC) CARDAMOM SEED, OIL~ -17-

PRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT CARROT, OIL CARROT SEED OIL* CARVACROL CARVOMENTHENOL, 4- CARVONE* CARYOPHYLLENE, BETA-* CARYOPHYLLENE OXIDE, BETA- CASCARILLA BARK EXTRACT* CASCARILLA BARK OIL* CASSIA* (bark, buds) CASSIA BARK, OIL* CASSIE, ABSOLUTE CASTORUM CASTORUM, EXTRACT* CEDAR LEAF OIL* CEDARWOOD, OIL* CELERY SEED* CELLULOSE* CELLULOSE ACETATE (On tobacco) CHAMOMILE FLOWER, OIL* CHERRY* CHICORY, EXTRACT CHLORIDE SALTS (methyl chloride) CINNAMON* (Code: DELLAT) CINNAMON* (Code: DELLAT) CINNAMYL ACETATE* CINNAMYL ALCOHOL* CINNAMYL BUTYRATE* CINNAMYL CINNAMATE* CINNAMYL ISOBUTYRATE* CINNAMYL ISOVALERATE* CITRONELLA OIL* CITRONELLOL, DL-* CITRONELLYL ACETATE* CITRONELLYL BUTYRATE* CITRONELLYL FORMATE* CITRONELLYL ISOBUTYRATE* CITRONELLYL PHEMYLACETATE* CITRONELLYL PROPIONATE* CIVET, ABSOLUTE CLARY, OIL* COCONUT, OIL COFFEE* COGNAC CORN SILK, EXTRACT CORNMINT, OIL CUBEB OIL* CUMIN* CYMENE, P- CYSTINE, L- DAMASCONE, BETA- DANDELION ROOT, EXTRACT DATE~ DAVANA, OIL -18-

PRIVILEGED AND CONFIDENTIAL ATTORNET WORK PRODUCT D.CARVONE DECALACTONE, DELTA- DECALACTONE, GAMMA- DEXTRIN* DEXTROSE DIACETYL DIATOMACEOUS EARTH* DIBENZYL ETHER* DIETHYL MALONATE DIETHYL PHTHALATE DIETHYL SEBACATE* DIHYDRO-2-METHYLTHIENO (3,4-D)PYRIMIDINE, 5,7- DILL, OIL DIMETHOXYBENZENE, M- DIMETHYL DISULFIDE DIMETHYL SUCCINATE DIMETHYL-I,2-CYCLOPENTADIONE, 3,4- DIMETHYL-5,9-UNDECADIEN-2-ONE, 6,10- DIMETHYLPHENETHYL BUTYRATE, ALPHA, ALPHA- DIMETHYLPHENYLETHYL BUTYRATE, ALPHA, ALPHA- DODECALACTONE, DELTA- DODECALACTONE, GAMMA- ELEMENE, BETA-* ELEMOL, BETA* ETHYL 2-METHYLBUTYRATE ETHYL 2-NAPHTHYL ETHER* ETHYL ACETATE* ETHYL ACETOACETATE ETHYL ACRYLATE* ETHYL ALCOHOL, ETHANOL (Code: ETHYL BENZOATE* ETHYL BUTYRATE* ETHYL CINNEMATE* ETHYL DECANOATE* ETHYL FORMATE* ETHYL GUAIACOL 4-* ETHYL HEPTANOATE* ETHYL HEXANOATE* ETHYL ISOVALERATE ETHYL LACTATE ETHYL LAURATE* ETHYL MALTOL ETHYL METHYL PHENYLGLYCIDATE ETHYL MYRISTATE* ETHYL MYRISTATE* ETHYL NONANOATE* ETHYL OCTANOATE* ETHYL OLEATE ETHYL PALMITATE* ETHYL P-ANISATE ETHYL PHENYLACETATE* ETHYL PROPIONATE* ETHYL SALICYLATE ETHYL VALERATE* _ GOLIC) -19-

PRIVILEGED A~D CONFIDENTIAL ATTORNEY WORK PRODUCT ETHYL- I-HEXANOL, 2- ETHYL- 3-HYDROXY-4-METHYL-2 ( 5H ) -FURANONE , 5- ETHYLCELLULOSE* ETHYLPYKIDINE, 3- EUCALYPTOL EUCALYPTUS OIL* FARNESOL* FENCHONE, D- FENNEL, OIL* FENUGREEK* FIG* FIG AROME FIG FLAVOR* (Code: FINCHA) FRUIT SYRUP (Codes: FUNGAL PROTEASE 4211 FURFURYL ALCOHOL FURFURYL MERCAPTAN FUSEL OIL, REFINED GENET, ABSOLUTE GERANIOL* GERANIUM, OIL* GERANYL ACETATE* GEKANYL FOR_MATE* GEKANYL HEXANDATE GERANYL I50BUTYRATE* G E .~N yL I SOVALERATE GE RANYL PHENYLACETATE* GERANYL PROPRIONATE* GINGER OIL* GLUTAMIC ACID, L- GLUTAMINE, L- GLYCINE GRAPE* GUAIAC WOOD, OIL* GUAIACOL* GUAIOL ACETATE GUAIYL ACETATE* GUM ARABIC* GUM BENZION GUM GUAR GUM TKAGACANTH* HEPTALACTONE, GAMIMA- HEXADECENELACTONE, OMEGA-6- HEXA.LACTONE, GAMMA- HEXANOL, 3- HEXEN-I-OL, 2- HEXEN-I-OL, 3- HEXEN-I-YL ACETATE, CIS-3- HEXENE-I-OL, HEXENE-I-YL ACETATE, HEXYL ACETATE* HEXYL ALCOHOL HEXYL BUTRYATE DOGGIT, UNADINE) -20-