Tobacco Documents Online

PRIVILEGED TO : FROM: DATE : RE: All Subjective Coders Mark B. Tinsle~ April 25, 1989 Brown & Williamson Tobacco CorD. Subjective Codinq Project - Substance Glossary Please add the attached to your coding manuals under the tab "CHEMICAL FORMULAS." This glossary will be updated as more information is obtained. Please destroy your copy with the cover memo dated May 19, 1988. co: Ernest J. Clements Lori A. Eubanks Laura A. Owens, Esq. Mary D. Sawyer Dan H. Willoughby, Esq. Mark D. Wilson, Esq. M.B.T.

1001 ACETALD~HTDEz PRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT .< CH3-HC=0 - flavor additive - gas phase constituent - narcotic action - mucus membrane irritant - suspected mucus flow inhibitor - LD50 orally to ra~s is 1.9/kg 1002 ACIDS (VOLATILE): (code: IMPOLL05, OKENTIC, PALGAN, ZEROTIC) NAMBA, DIKARY, IKONDA, 1003 ACRO~IN: H2C'CH-HC'0 - gas phase constituent - skin and mucus membrane irritant - suspected mucus flow inhibitor - LD50 orally to rats is 26 mg/kg 1004 ALDEHYDES: TORMIN)) (code: VALSEDON, ASHLEY, DARBONEX, GIVAUDAN, - gas phase constituent - irritants - ciliastants 1005 AMMONIA: NH3 1006 ANTHRACENES: - particulate phase constituent - a polycyclic aromatic hydrocarbon - suspected lung carcinogen -i-

PRIVILEGED AND CONFIDENTIAL ATTORNET WORK PRODUCT ~007 ARSENIC ~As) and compounds: - particulate phase constituent - most are toxic - suspected lung carcinogen 1008 ASBESTOS: - Micronite filter component - causes asbestosis and/or lung cancer disease due to protracted inhalation of asbestos - statistical synergistic effect with smoking for lung cancer 1009 AZA-ARENES: - particulate phase constituents - general classification for compounds with a nitrogen atom substituted for a carbon atom (=aza) or an aromatic hydrocarbon (-arene) - suspected carcinogen - a polycylic aromatic hydrocarbon 1010 AZO DYES: - used in cork wrapping paper 1011 BALSAMS : - flavor additives -2-

PRSVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT 10!2 ~ENZOPERTT~E~E: - particulate phase constituent - polycyclic aromatic hydrocarbon - suspected lung carcinogen (benzoperylene has an additional benzene ring attached) 1013 BENZO{a)PTR~NE, Bap, BENZPTRENE: - particulate phase constituent - when converted to diol epoxide is highly carcinogenic - suspected lung carcinogen 1014 BENZODIHYDROPYRONE: (code: DANKIN) 1015 BROWN SUGAR: (code: RAGRAW, AVALOW, INVERT AVALADE) - flavor/humectant additive 1016 CADMIUM (Cd) and compounds: - particulate phase constituents - when inhaled (dust or fumes) causes throat dryness, cough, headache and chest pain

PRIVILEGED AND CONFIDENTIAL ATTOR/~E" WORK PRODUCT 1017 CARBAZOLE$: - particulate phase cons£1£uent - LD50 orally to rats is >5g/kg - polycyclic aromatic hydrocarbons - suspected lung carcinogen 1018 CARBON MONOZIDE (CO): - gas phase constituent - causes hypoxia in high concentrations; thought to contribute to carboxyhemoglobanemia which compromises gas exchange and can precipitate angine/ischemia in people with cardiovascular disease 1019 CARDAMOM: (Code: FRINOT) - flavor additive 1020 CAROB BEAN : - flavor additive - also called CAROB BEAN GUM or ST. JOHNS BREAD 1021 CATEC~OLS: - flavor additive - particulate phase constituent - can cause dermatitis - topical antiseptic - LD50 orally to rats is 3.89 g/kg - alleged co-carcinogen -4-

PRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT ~22 CH~MO$OL: - additive which in the late 1960's was thought to reduce BaP delivery and therefore reduce cancer risk; mouse skin painting tests proved theory was invalid 1023 CHOCOLATE: "(co~e: CLIFFO, NEWVAC, CELPOR, KENZEY, FIRZIT, WEDABY, CARVAN, CALSIS) 1024 - flavor additive - suspected carcinogen CHRYSENES: - particulate phase constituent - polycyclic aromatic hydrocarbons - suspected lung carcinogen 1025 CITRIC ACID, CITRATES: (code: DURLOCK, EKPHON) - paper additive, burn retardants 1026 - flavor additive -5-

PRIVILEGED AND CONFIDENTIAL ATTORNE, WORK PRODUCT I0;7 COCOA, COCOA SHELLS: 1028 - flavor additive - suspected carcinogen CONDENSATe, WS~ CSC: - portion of cigarette smoke trapped in a cold trap (codes: BINNET, COPLOR, MESMOR, CONDRA, HARIKAN, COARCH, CROTAN, CELMOE, KUPTIE) 1029 COR;ANDER: (code: ORANG, FRIBAD) - flavor additive 1030 CORN STRUP: (code: HUMECTOSE, HUMLOR) - flavor/humectant additive 1031 COTININE: - metabolite of nicotine - measured in urine and plasma 1032 ROMINK) ¢OUMARIN: (code: RANDEP, SYNTHOS, SYNLOR, KESCON, - flavor additive - ingestion allegedly causes hepatic (liver) tumors in baboons 1033 - particulate phase constituent - disinfectants - LD50 orally to rats is 1.35-2.02 g/kg - phenol - suspected mucus flow inhibition

pRIViLEGED AND CONFIDENTIAL ATTOKNEY WORK PRODUCT 1034 DEER TON~E: - flavor additive - contains COUMARIN (code: CARPAS ) 1035 DIBENZACRIDINE$: - particulate phase constituent - polycyclic aromatic hydrocarbon - suspected lung carcinogen acridine (dibenzacridine has two additional benzene rings) 1036 EUGENOL: - additive - irritant - potentially hazardous 1037 FLUORANTHENES: - particulate phase constituent - polycyclic aromatic hydrocarbon - suspected lung carcinogen 1038 FORMALDEHYDE: H2-CH=0 - gas phase constituent - irritant - ciliastant - suspected mucus flow inhibitor -8-

pRIVILEGED AND CONFIDENTIAL A~TORNET WORK PRODUCT 1039 GLYCEROL, GLYCERINE.: (code: CELANDO) 1040 - humectant additive - potentially hazardous - when burned is transformed to ACROLEIN GLTCOL$, DEG, TEG, ?E~: (code: GRELANTER, FABRACE) - humectant additive - possible hazardous, substances - triethylene glycol when burned produces 1,4 dioxane, a known carcinogen 1041 particulate phase constituent polycyclic aromatic hydrocarbons suspected lung carcinogen 1042 HELIOTROPIN: (code: HId~LET) - plant hormones 1043 HYDRAZINE: H2-N-N-H2 - gas phase constituent - irritating to mucus membranes 1044 HYDROGEN CYANIDE, HCN: - gas phase constituent - suspected mucus flow inhibitor - fatal dose: 50-60 mg 1045 INDQLE$: - particulate phase constituent - LD50 orally to rats is ig/kg - polycyclic aromatic hydrocarbons - suspected lung carcinogen 1046 INVERT SYRUP: (code: - humectant additive MOLON, QUASER) -9-

PRIVILEGED AND CONFIDENTIAL ATTORNEY WORK PRODUCT 1Q47 LICORICE: (codes: AMDINER, CARRUS, ILKARO, AMSPIN) - flavor additive 1048 MACE: (code: - flavor additive DENS~VE, MATILE, LEKAFT) 1049 +2, Mn+21 METALS (e.q. Mg : - free radicals - suspected carcinogen 1050 MENTHOL: (codes: - flavor additive KINTOLLY, TOLKIN, HARPAT, POLAR BEAR, CENMAP) 1051 NICKEL (Ni) and compounds: - particulate phase constituent - may cause dermatitis - Nickel carbonyl, Ni(C0)4, may cause lung cancer with prolonged exposure -i0-