Tobacco Documents Online

Reviews two separate studies on atherosclerosis in ETS- exposed rabbits and cockerels, respectively. Highlights methods and results, and includes data for each. Emphasizes Zhu et al. finding of "ETS concentration-dependent increase of lipid deposits in aorta and pulmonary artery." Notes that Penn and Snyder cockerel study concluded that "daily FSS [Fresh Sidestream Smoke] exposure early in life accelerates atherosclerotic plaque development." Ends review with exclamation that Penn and Snyder study was "sponsored by CIAR!"

Encloses research proposal for review in fulfillment of recipient role as "consultant to BAT." Seeks advice regarding the proposal's methodology and overall feasibility (study on artherosclerosis). Reports, "with regard to your own research proposal, this was discussed at a recent meeting of BAT scientists, and we will be in touch with you shortly to follow up on a few points which were raised."

Addresses research areas of "mutual interest" to American Health Foundation and Philip Morris: the Sweitzer Process for preparing reconstituted tobacco that produced "a particularly low tumor yield in the NCI study" and the association of carbon monoxide from cigarette smoke and artherosclerosis.

Offers background and preliminary comments on "Cigarette Smoking and Progression of Atherosclerosis" study, published in JAMA. Critiques categorization of ETS exposure and evaluation of ultrasound information measuring thickness of carotid artery walls. Disputes author claim that active smoking and ETS exposure are risk factors for atherosclerosis. Cites numerous studies to support position. Document appears to be incomplete.

Reviews paper titled, "The Tumorigenic Theory of Atherosclerosis." Ridicule's authors theory that disease is caused by genetic susceptibility, eliminating other possible causal agents such as smoking, lack of exercise, etc. Posits that while genetic factors may play a role in the etiology of atherosclerosis, "it is extremely unlikely that all his list of risk factors have no causal effect." Opines that author's research on subject will undermine his credibility regarding his work on smoking and lung cancer.