Tobacco Documents Online

Subject: Coumarin

Abstract

Lists reasons for recommending that coumarin continue to be used "at levels less than 0.06% on Company products," despite OSHA listing of coumarin as a Class 1 chemical. Explains classification and that coumarin fits in as a substance shown to be carcinogenic in one mammalian species in which tests were replicated. Describes study of coumarin-fed rats producing liver tumors at higher levels and asks, "how does this daily dose administered to the rats compare with a smoker's exposure to coumarin in the smoke from a pack of cigarettes?" Opines that extrapolating rat data to human exposure results in "entirely unrealistic" dose levels in humans. Includes table comparing coumarin data across brands I=for 1977-1978. States, "only PM does not use this flavorant in its cigarettes."

Fields

Type

Memorandum

Company

RJ Reynolds Tobacco Co.

R&D

Site

MN Depository

Author

Rodgman, Alan

Recipient

Witt, Samuel B. III

Named Person

Laurene, A.H.

Baer

Griepentrog

Hagan

Named Organization

OSHA

RJR

Hunter Committee

PM

FDA

Brand

Now

Vantage

Winston

Marlboro

Marlboro Lights

Merit

Benson and Hedges

Lucky 100

Iceberg

Carlton 70

Carlton 85

Viceroy

Raleigh

Kool 85

Kent 85

Flavor Lights

Vello 85

Thesaurus Term

Industry Sponsored Research

Animal Subjects

Government Agencies

Data Analysis

Coumarin

Additives