Mayo Clinic
SPECIFIC ACCOMPLISHMENTS FOR THE NICOTINE PROGRAM
Abstract
Lists accomplishments of the "Nicotine Program" by subject area: 1) synthesis and chemistry of nicotine analogues 2)behavioral pharmacology and 3)external pharmacology. Notes under "synthesis of analogues" that "2'-Methylnicotine is of particular interest since it is equipotent with nicotine in behavioral studies and causes hypotension in rats injected via the jugular vein." States that in behavioral pharmacology studies, "we have demonstrated in our laboratory that nicotine can function as an intravenously delivered positive reinforcer in rats" and that behavioral disruptions occur in rats for 10-12 minutes after infusion of nicotine. Comments that "this represents a substantial improvement over Dr. Abood's activity scale where recovery is apparent in 3-5 minutes." Notes Dr. Abood's continued support of the Nicotine Program and lists activities of his lab including testing nicotine analogues "for binding to glass fiber filters, rat blood pressure and prostration syndrome."
Fields
- Notes
Analogue is a chemical compound that is structurally similar to another but differs slightly in composition (as in the replacement of one atom by an atom of a different element or in the presence of a particular functional group)
- Type
- Report
- Outline
- Company
- Philip Morris
- R&D
- Site
- MN Depository
- Named Person
- Abood, Leo (PM Researcher, Nicotine)Outside research on nicotine analogs for PM. University of Rochester. Around 1980.
- Named Organization
- Medical College of Virginia
- University of Rochester
- Thesaurus Term
- Nicotine
- Industry Sponsored Research
- Behavior
- Animal Subjects
- Nicotine Analogues
- Industry Sponsored Research
No images found for document.