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Lorillard Exhibits for Individual Personal Injury Cases

Date: 30 Sep 1999 (est.)
Length: 79 pages
98287923-98288001
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10 Apr 2002
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98287700/98288288/Lorillard Tobacco Company in the Circuit Court of Ohio County, West Virginia in Re Tobacco Litigation (Individual Personal Injury Cases) No. 00-C-5000
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R1-037
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gsl53c00

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Page 1: gsl53c00
Exhibit Description: Document Name: Date: LOR-10083 Kennedy, T.C., et al., "Cytopathological Analysis of Sputum in Patients with 00/00/1996 Airflow Obstruction and Significant Smoking Histories," Canc Res 1996 OR-10084 Kottke, T.E., "A Randomized Trial to Increase Smoking Intervention by 00/00/1989 Physicians: Doctors Helping Smokers, Round 1," JAMA 261:2101 (1989) LOR-10085 Kottke, T. E., et al., "Attributes of successful smoking cessation interventions in 00/00/1988 Medical Practice," JAMA 259:2883 (1988) LOR-10086 Kroon, A.A., et al., "The Prevalence of Peripheral Vascular Disease in Familial 00/00/1995 Hypercholesterolemia," Journal of Internal Medicine 238: 451-45. (1995) LOR-10088 Lantz, P.M., et al., "Socioeconomic Factors, Health Behaviors, and Mortality: 06/03/1998 Results from a Nationally Representative Prospective Study of US Adults," Journal of the American Medical Association, 279(21): 1703-1708, June 3, 1998 LOR-10089 Larson, et al., "Tobacco, Experimental and Clinical Studies," The Williams and 00/00/1961 Wilkins Co. 1961 LOR-10090 Law, M.R.; et al., "Environmental Tobacco Smoke Exposure and Ischemic 1 011 8/1 9 8 7 Heart Disease: An Evaluation of the Evidence," BMJ 315:973-980, October 18, 1987 LOR-10091 LeVoise, M.E. and Layard, M.W., "Publications Bias in the-Environmental 00/00/1995 Tobacco Smoke/Coronary Heart Disease Epidemiologic Literature," Regulatory Toxicology and Pharmacology 21:184-191, 1995 LOR-10092 Levy, R.I. and Fenleib, M., "Risk Factors for Coronary Heart Disease and their 00/00/1980 Management," Heart Disease. A Textbook of Cardiovascular Medicine. E. Braunwald (ed.). W.B. Saunders Company, Philadelphia, Chapter 34, pp. 1246-1278, 1980 LOR-10093 Longstreth, W.T. and Swanson, P.D„ "Oral Contraceptives and Stroke," 00/00/1984 Stroke 15(4): 747-750, 1984 LOR-10094 Lynch, J.W., et al. "Do Cardiovascular Risk Factors Explain the Relation , 00/00/1996 Between Socioeconomic Status, Risk of All-Cause Mortality, Cardiovascular - Mortality, and Acute Myocardial Infarction?," American Journal of Epidemiology 114(10): 934-942, 1996 LOR-10095 Mariotti, et al., "Age, Period, Cohort and Geographical Area Effects on the 00/00/1986 Relationship Between Risk Factors and Coronary Heart Disease. Fifteen Yea Follow-Up of the European Cohorts of the 7 Countries Study," J Chron Dis 39:229, 1986 LOR-10096 Marmot, M.G. and Poulter, N.R., "Primary Prevention of Stroke," The Lancet 00/00/1992 339:344-347 (1992) LOR-10097 Nash, et al., "South London Lung Cancer Study," Brit Med J 715, 1968 00/00/1968 LOR-10098 McBride, et al., "Use of Health Services By Children of Smokers and Non- 00/00/1988 Smokers," Am J Publ Health 88:897 (1988) LOR-10100 Menotti, A., et al., "Comparison of Multivariate Predictive Power of Major Risk 00/00/1996 Factors for Coronary Heart Disease in Different Countries," J. Card. Risk.3:69- 75. (1996) LOR-10101 Menotti, A., et al., "Inter-Cohort Differences in Coronary Heart Disease 00/00/1993 Mortality in the 25-Year Follow-Up of the Seven Countries Study," Eur. J. Epidemiol. 9(5): 527-533. (1993) LOR-10102 Molgaard, J., et al., "Hyperhomocyst(e)inaemia: An Independent Risk Factor 00/00/1992 for Intermittent Claudication," Journal of Internal Medicine 231: 273-79. (1992 OR-10103 Morabia and Wynder, "Dietary Habits of Smokers, People Who Have Never 00/00/1990 Smoked, and Ex-Smokers," Am J Clin Nutr 52:933 (1990) Page 3 of 79 98287925
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Exhibit Description: Document Name: Date: LOR-10196 Gori, G.B., "Environmental tobacco smoke and coronary heart syndromes: 00/00/1995 absence of an association," Regulatory Toxicology and Pharmacology 21 :281 - 295(1995) LOR-10197 Gori, G.B., and Mantel, N., "Mainstream and environmental tobacco smoke," 00/00/1991 Regulatory Toxicology and Pharmacology 14:88-105 (1991) LOR-10198 Halcy, J., et al., "Uptake of Sidestream Smoke by Syrian Golden Hamsters," 0 0/0 011 9 8 7 Toxicology Letters 35:83-88, 1987 LOR-10199 He, Y., Lam, T.H., Li, L.S., et al., "Passive Smoking at Work as a Risk Factor 00/00/1994 for Coronary Heart Disease in Chinese Women Who Have Never Smoked," British Medical Journal 308:380-384, 1994 LOR-10200 Helsing, K.J., etal:, "Heart Disease Mortality in Nonsmokers Living With 00/00/1988 Smokers," American Journal of Epidemiology 127(5):915-922, 1988 LOR-10201 Hirayama, T., "Cancer mortality in nonsmoking women with smoking husband 00/00/1984 based on large-scale cohort study in Japan." Prevent. Med. 13:680-690, 1984a LOR-10201A Hirayama, T., "Lung cancer in Japan: Effects of nutrition and passive 00/0011984 smoking," In: Mizell M, Correa P, eds. Lung Cancer: Causes and Prevention. Verlag Chemie International, 175-195, 1984b LOR-1 0202 Hole, D.J., et al., "Passive Smoking and Cardiorespiratory Health in a General 00/00/1989 Population in the West of Scotland." British Medical Journal 299:423-427, 1989 LOR-1 0203 Huber, G.L. and Brockie, R.E., "Passive smoking and heart disease." 00/00/1991 Circulation 84(4):1878-9 (1991) LOR-1 0204 Humble, C., et al., "Passive Smoking and 20-Year Cardiovascular Disease 00/00/1990 Mortality among Nonsmoking Wives, Evans County, Georgia," American - Journal of Public Health 80(5):599-601, 1990 LOR-10205 Humble, C.G., et al., "Marriage to a smoker and lung cancer risk," Am. J. 00/00/1987 Public Health 77(5):598-602, 1987 LOR-10206 Inoue, R., Hirayama, T., "Passive smoking and lung cancer in women." In: 00/00/1988 Aoki, M., Hisamichi, S., Tominaga, S., eds. Smoking and Health 1987. Amsterdam: Excerpta Medica, Elsevier Science Publishers, 283-285, 1988. LOR-10207 Janerich, D.T., et al., "Lung cancer and exposure to tobacco smoke in the 00/00/1990 household," N. EgI. J. Med. 323:623-636, 1990 LOR-1 0208 Ji, C., Plopper, C., et al., "Exposure to Sidestream Cigarette Smoke Alters 00/00/1994 Bronchiolar Epithelial Cell Differentiation in the Postnatal Rat Lung," Am J Respir Cell Mol Biot 11:312-320, 1994 LOR-10209 Joad, J., et al., "Effects of Sidestream Smoke Exposure and Age on . 00/00/1993 Pulmonary Function and Airway Reactivity in Developing Rats," Pediatric Pulmonology 16:281-288, 1993 LOR-10210 Joad, J., et al., "Sidestream Smoke Effects on Lung Morphology and.C-Fibers 00/00/1995 in Young Guinea Pigs," Toxicol Appl Pharmacol 131:289-296, 1995 LOR-10211 Joad, J., et al., "In Utero and Postnatal Effects of Sidestream Cigarette Smoke 00/00/1995 Exposure on Lung Function, Hyperresponsiveness, and Neuroendocrine Cells in Rats," Toxicol Appl Pharmacol 132:63-71, 1995 LOR-10212 Kabat, G.C., Stellman, S.D., Wynder, E.L., "Relation between exposure to 00/00/1995 environmental tobacco smoke and lung cancer in lifetime nonsmokers." Am. J. - Epidemiol. 142(2):141-8, 1995 OR-10214 Kalandidi, A., et al., "Passive smoking and diet in the etiology of lung cancer 00/00/1990 among non-smokers," Cancer Causes and Control 1:15-21, 1990 Page 8 of 79 98287930
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Exhibit Description: Document Name: Date: LOR-10420 Charleston Gazette, October 12, 1954, p. 1, "Lung Disease Related to 10/12/1954 Smoking - Give Up Cigarettes, Cancer Group Urges" OR-10421 Charleston Gazette, January 1, 1955, p. 5, "Filtered Srrioke Held Little Help to 01/01/1955 Balk Cancer" LOR-10422 CharlestorrGazette, February 11, 1955, p. 21, "Specialist Links Smoking to 02/11/1955 Bad Heart Condition" LOR-10423 Charleston Gazette, June 3, 1955, p. 9, "Cancer Discovery May Give Smokers 0 610 3/1 9 5 5 Cause to Worry" LOR-10424 Charleston Gazette, December 4, 1955, p. 37, "Doctors Still Argue Cigarettes 12/04/1955 and Cancer" LOR-10425 Charleston Gazette, June 6, 1956, p. 11, "'Baby' Cancer Spots Found In 06/06/1956 Cigarette Smokers' Lung," by Alton L. Blakeslee LOR-10426 Charleston Gazette, February 27, 1956, p. 8, "Expert Reveals Evidence Of 02/27/1956 Smoking-Cancer Tie-Up" LOR-10427 Charleston Gazette, April 15, 1956, p. 8, "Cancer-ProducerTn Tobacco Found 04115/1956 - Value of Filter Tip Seen as Debatable" LOR-10428 Charleston Gazette, June 6, 1957, p. 19, "Stop Smoking, Improve General . 06/06/1957 Health, Doctor Advises," by David M. Cleary LOR-10429 Charleston Gazette, July 30, 1957, p. 5, "Battle Started Early - Smoking Grow 07/30/1957 Despite Foes" LOR-10430 Charleston Gazette, October 21, 1957, p. 1, cont'd. 24, "Tobacco May Hurt 10/21/1957 Heart, Doctor Tells Symposium," by Harry W. Ernst LOR-10431 Charleston Gazette, December 27, 1957, p. 12, "Cigarette Use Mounts 12/27/1957 Despite Cancer Scare" LOR-10432 Charleston Gazette, December 27, 1957, p. 14, "Cigarette Tar Found to Give 12/27/1957 Mice Cancer" LOR-10433 Charleston Gazette, July 6, 1958, p. 10, "Smokers Fail In Statistics - Cigarette 07/06/1958 Users Lead All In Precentage of Deaths" LOR-10434 Charleston Gazette, September 6, 1958, p. 1, "Smoking DescribedAs'Vicious 09/06/1958 Poison," by Harry Ernst LOR-10435 Charleston Gazette, May 8, 1959, p. 19, "New Study Affirms Smokers More 05/08/1959 Likely to Catch Cancer," by David M. Cleary LOR-10436 Charleston Gazette, November 27, 1959, p. 1, cont'd. 12, "Smoking Said Top 1 112 7/1 9 5 9 Cause Of Lung Cancer Increase" LOR-10437 Charleston Gazette,. December 3, 1959, p. 3, Cartoon, "I just can't stand to 12/03/1959 inhale when I have a sore throat- -" LOR-10438 Charleston Gazette, April 8, 1960, p. 44, "Specialist Links Cigarettes to Lung 04/08/1960 Cancer" LOR-10439 Charleston Gazette, June 6, 1960, p. 4, "Heart Ills Attributed To Smoking" 06/06/1960 LOR-10440 Charleston Gazette, May 11, 1961, p. 32, "Red Scientist Sees Cancer Link in 05/11/1961 Smoking" LOR-10441 Charleston Gazette, December 7, 1961, "Foe Of Alcohol Says Cigarettes 12I0711961 Health Menace" LOR-10442 Charleston Gazette, June 23, 1962, p. 3, "Cigarettes on TV From Colleges Hit' 06/23/1962 LOR-10443 Charleston Gazette, July 16, 1962, p. 1, "Brain Damage In Babies -.Smoking 07/16/1962 Linked To Prematurity;" by Robert F. Whitney LOR-10444 Charleston Gazette, April 15, 1963, p. 21, "Baby Size Is Linked-To Smoking" 04/15/1963 OR-10445 Sunday Gazette-Mail, June 9, 1963, p. 16A, "Heart Group Favors Curbs On 0 6109/1 96 3 Smoking" - " Page 16 of 79 98287938
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Exhibit Description: Document Name: Date: LOR-10253 Stockwell, H.G., et al., "Environmental tobacco smoke and lung cancer risk in 0 010 0/1 9 9 2 nonsmoking women," J. Natl. Cancer Inst. 84(18):1417-1422 (1992) OR-10254 Sun, Y., et al., "Metoprolol Does Not Attenuate Atherosclerosis in Lipid-Fed 00/00/1994 Rabbits Exposed to Environmental Tobacco Smoke," Circulation 89(5):2260- 2265 (1994) LOR-10255 Svensson, C., Pershagan, G., Klominek, J., "Smoking and passive smoking in 00/00/1989 relation to lung cancer in women," Acta Oncol., 28(5):623-629, 1989 LOR-10256 Takenawa, J., et al., "Urinary Excretion of Mutagens and Covalent DNA 00/00/1994 Damage Induced in the Bladder and Kidney After Passive Smoking in Rats," Urol Res 22:93-97 (1994) LOR-1 0257 Tanaka, I., et al., "Cumulative Toxicity Potential of Hardwood Dust and , 00/00/1991 Sidestream Tobacco Smoke in Rats by Repeated Inhalation," Inhalation Toxicology 3:101-112 (1991) LOR-10258 Teague, S., et al., "Sidestream Cigarette Smoke Generation and Exposure 00/00/1994 System for Environmental Tobacco Smoke Studies," Inhalation Toxicology - 6:79-93 (1994) LOR_ -10259 Teredesai, A., Pruhs, D., "Histopathological Findings in the Rat and Hamster 00100/1993 Respiratory Tract in a 90-Day Inhalation Study Using Fresh Sidestream Smoke of the Standard Reference Cigarette 2R1," Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract 629-635, 1993 LOR-10260 Trichopoulos, D., Kalandidi, A., Sparros, L., "Lung cancer and passive 00/00/1983 smokingc Conclusion of Greek study [letter]," Lancet 2(8351):677-8, 1983 LOR-10261 Tunstall-Pedoe, H., et al., "Passive Smoking By Self Report and Serum 00/00/1995 Cotinine and the Prevalence of Respiratory and Coronary Heart Disease in the Scottish Heart Health Study," Journal of Epidemiologyand Community Health 49:139-143, 1995 LOR-1 0262 von Meyerinck, L., et al., "Exposure of rats and hamsters to sidestream smoke 00/00/1989 from cigarettes in a subchronic inhalation study," Exp. Pathol. 37:186-189, 1989 LOR-10263 Waldum, H.; et al., "Long-Term Effects of Inhaled Nicotine," Life Sciences 00/00/1996 58(16):1339-1346, 1996 LOR-10264 Wang, F-L, Love, EJ, Lui, N, Dai, X-C.; "Childhood and adolescent passive 00/00/1994 smoking and the risk of female lung cancer," Int. J. Epidemiol. 23(2):223-30; 1994 LOR-10265 Weetman, D.F., "Environmental tobacco smoke. In: Risk factors for 00/00/1993 cardiovascular disease in non-smokers," Int. Workshop, Washington, Tyne & Wear, Basel Karger, 1993:129-136. Eds. D.F. Weetmand and D. Wood LOR-10266 Wehner, A.P., et al., "Inhalation bioassay of cigarette smoke in rats," Toxicol. 00/00/1981 Appl. Pharmacol. 61, 1-17, 1981 LOR-1 0267 Witschi, H., Oreffo, V., Pinkerton, K., "Six-Month Exposure of Strain A/J Mice 0 0/0 011 9 9 5 to Cigarette Sidestream Smoke: Cell Kinetics and Lung Tumor Data," Fundam Appl Toxicol 26:32-40, 1995 LOR-10268 Witschi, H., et al., "Effects of Exposure to Nicotine and to Sidestream Smoke 0 0/0 011 9 94 on Pregnancy Outcome in Rats," Toxicology Letters 71:279-286, 1994 LOR-10269 Witschi, H., Rajini, P., "Cell Kinetics in the Respiratory Tract of Hamsters 00/00/1994 Exposed to Cigarette Sidestream Smoke," Inhalation Toxicology 6:321-333, 1994 • 98287933 Page 11 of 79
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Exhibit Description: Document Name: Date: LOR-10446 Charleston Gazette, June .12, 1963, p. 2, "Canadian Doctors Ask Smoking 06/1211963 Curb" OR-10447 Charleston Gazette, July 24, 1963, p. 6, "California Moves Against Cigarettes,' 07/24/1963 by Harry Nelson LOR-10448 Charleston Sunday Gazette-Mail, August 4, 1963, p. 7A, "Smoking - 0 8/0411 96 3 Cigarettes Said Deadly As Bombs in WHO Report" LOR-1 0449 Charleston Gazette, September 7, 1963, p. 2, "State Heart Group to Join Fight 09/07/1963 Against Cigarettes" LOR-10450 Charleston Gazette, October 24, 1963, p. 1, "Dyer Attacks Tobacco Habit" 10/24/1963 LOR-10451 Charleston Gazette, December 5, 1963, p. 11, "Nation's Experience Shows - 12/05/1963 Smokers Don't Scare," by W. Joynes MacFarlan LOR-1 0452 Charleston Gazette, December 5, 1963, p. 19, "One Study Bared, Another 12/05/1963 Begun - Smoker Deaths Claimed Higher" LOR-10453 Charleston Gazette, December 6, 1963, p. 22, "Union to Fight Over Smoking" 12/06/1963 LOR-10454 Charleston Gazette, January 2, 1964, p. 15, "Lung Cancer ToII Laid to 01/02/1964 Smoking," by David Anderson LOR-10455 Sunday Gazette-Mail, January 12, 1964, p. 10A, "Cancer Link Dates'to'36" .' 01112/1964 LOR-10456 Charleston Gazette, January 16, 1964, p. 8, "Cigarette Report Creates : 01/16/1964 Problems" LOR-10457 Charleston Gazette, January 16, 1964, p. 8, "Smoking" 01/16/1964 LOR-10458 Charleston Gazette-Mail, January 12, 1964, p. 1, "Coffin Nails? Remedial . 01/12/1964 Action Urged To End Smoker Hazard," by Frank Carey LOR-1 0459 Sunday Gazette-Mail, January 12, 1964, p. 6C, "Here's The Story - Habitual 01/12/1964 Cigarette Smoking Ruled Actual Health Hazard" LOR-10460 Charleston Gazette, January 12, 1971, p. 6, "Smoking Hazards To Mothers 01/12/1971 Aired," by Martha Cole LOR-10461 Charleston Gazette, January 23, 1964, p. 2, "Premature Babies Laid To 01/23/1964 Smoking" LOR-10462 Charleston Gazette, January 26, 1971, p. 12, "Study Links Cigarettes To Fatal 01/26/1971 Heart Attacks" LOR-1 0463 Charleston Gazette, March 3, 1964, p. 13, "Anticigarette Materials Seen 03/03/1964_ Pressing Need" LOR-1 0464 Charleston Gazette, March 9, 1964, p. 3, "Many N.Y. Deaths'Laid To 03/09/1964 Smoking" LOR-1 0465 Charleston Gazette, March 28, 1964, p. 6, "Pure Evil" . 03/28/1964 LOR-10466 Charleston Gazette, May 16, 1964, p. 11, "Respiratory Danger-Seen.in 05/16/1964 Cigarettes - Smokers' Ailments Worse, Doctor Says," by Glade Little LOR-1 0467 Charleston Gazette, October 9, 1964, p.-1, "Women Smoker Risks Cited," by 10/09/1964 Alton Blakeslee LOR-10468 Charleston Gazette, November 24, 1964, p. 17, "Doctors Advise Cut in . 11/24/1964 Smoking" LOR-10469 Charleston Gazette, January 19. 1965, p. 3, "Doctors quit smoking" 01/19/1965 LOR-10470 Charleston Gazette, March 24, 1965, p. 21, "Lung Cancer Gain Cited - 03/2411 9 6 5 Cigarette Danger Label Pushed" LOR-10471 Charleston Gazette, July 28, 1965, p. 1, "Cigarette Hazard Tag Made Law" 07/28/1965 LOR-10472 Charleston Gazette, February 23, 1966, p. 22, "Smoking, Pollution Warning 02/23/1966 Sounded" OR-10473 Charleston Gazette, February 23, 1966, p. 22, "Rate of Death, Cancer Higher 02/23/1966 Among Smokers," by Frank Carey - Page 17 of 79 9828T939
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Exhibit Description: Document Name: Date: LOR-10158 Wolpaw, "Early Detection in Lung Cancer. Case Finding and Screening," 00/00/1996 Medical Clinics of North America 80:63 (1996) OR-10159 Woolf, S.H., et al., "Health Promotion and Disease Prevention in Clinical 00/00/1996 Practice," Chapters 21 and 27, (eds. Williams and Wilkins) 1996 LOR-10160 World Health Organization, "Cardiovascular Disease Risk Factors: New Areas 00I00/1994 for Research," WHO Technical Report Series 841, Geneva, 1994 LOR-10161 Akiba, S., Kato, H., Blot W.J., "Passive smoking and lung cancer among 00/00/1986 Japanese women," Cancer Rs 46:4804-4807, 1986 LOR-10162 Alavanja, M.C.R., et al., "Avian exposure and risk of lung cancer in women in 00/00/1996 Missouri: population based case-control study," British Medical Journal 313:1233-1235 (1996) LOR-10163 Alavanja, M.C.R., et al., "Saturated Fat Intake and Lung Cancer Risk Among 00/00/1993 Nonsmoking Women in Missouri," Journal of the National Cancer Institute 85(23):1906-1916 (1993) LOR-10164 Armitage, A. K., "Environmental tobacco smoke and coronary heart disease," 00/00/1993 Journal of Smoking-related Diseases 4(1):27-36 (1993) LOR-10165 Aviado, D.M., "Cardiovascular disease and occupational exposure to 00/00/1996 environmental tobacco smoke," American Industrial Hygiene Association Journal 57:285-294 (1996) LOR-10166 Aviado, D.M., "Occupational Lung Disease and Environmental Tobacco 00/00/1995 Smoke," International Joumal of Occupational Medicine and Toxicology 4(3):383-407, 1995 LOR-10167 Bonham, A.C., et al., "Exposing Young Guinea Pigs to Sidestream Tobacco 00/00/1995 Smoke Decreases Rapidly Adapting Receptor Responsiveness," J Appl Physiol 78(4):1412-1420, 1995 OR-10168 Brooks, W., et al., "Contractile Performance of Rat Myocardium after Chronic 00/00/1982 Tobacco Smoke Inhalation," Archives of Environmental Health 37(2):93-97, 1982 LOR-10169 Brownson, R.C., et al., "Risk factors for adenocarcinoma of the lung," Am. J. 00/0011987 Epidemiol. 125:25-34, 1987 LOR-10170 Brownson, R.C., et al., "Passive smoking and lung cancer irrnonsmoking 00/00/1992 women," Am. J. Public Health 82(11):1525-1530, 1992 LOR-10170A Butler, W.J., "Workplace Exposure to ETS and Lung Cancer: a more detailed 00/00/1992 presentation of the data from a negative study," Brownson, et al., (1992). - Submission to OSHA [Docket No. H-122], August, 1994 (Docket No. 9-47597) LOR-10171 Buffler, P.A., et al., "The causes of lung cancer in Texas," In: Mizell, M., 00/00/1984 Correa, P., eds. Lung cancer: Causes and Prevention. New York: Verlag Chemie International, 83-99, 1984 LOR-10172 Burns, A., et al:, "Respiratory Epithelial Permeability After Cigarette Smoke 0010011989 Exposure in Guinea Pigs," J Appl Physiol 66(5); 2109-2116, 1989 LOR-10173 Butler, T.L., "The relationship of passive smoking to various health outcomes 00/00/1988 among Seventh-Day Adventists in California [dissertation]," Los Angeles: - University of California at Los Angeles, 1988 LOR-10174 Cardenas, V.M., et al., "Environmental tobacco smoke and lung cancer 00/00/1997 mortality in the American Cancer Society's Cancer Prevention Study II," Canc. Caus. Contr. 8:57-64, 1997 LOR-10175 Carlo, G.L., et al., "The interplay of science, values, and experiences among 00/00/1992 scientists asked to. evaluate the hazards of dioxin, radon, and environmental tobacco smoke," Risk Analysis 12(1):37-43 (1992) - Page 6 of 79 98287928
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Exhibit Description: Document Name: Date: LOR-10270 Wu, A., Yu, M., Thomas, D., Pike, M., Henderson, B., "Personal and Family 0 0/0011 9 8 8 History of Lung Disease as Risk Factors for Adenocarcinoma of the Lung," Cancer Research 48:7279-7284, 1988 LOR-10271 Wu, A.H., Henderson, B.E., Pike, M.C., Yu, M.C., "Smoking and other risk 0010011985 factors for lung cancer in women," J. Natl. Cancer Inst., 74(4):747-751, 1985 LOR-10272 Wu-Williams, A.H., et al., "Lung cancer among women in north-east China," 00/00/1990 Br. J. Cancer 62(6):982-987, 1990 LOR-10274 Zhu, B., et al., "Passive Smoking Increases Experimental Atherosclerosis in 0 0/0011 9 9 3 cholesterol-Fed Rabbits," JACC 21(1):225-232, 1993 LOR-10275 Zhu, B., et al., "Exposure to Environmental Tobacco Smoke Increases 00/0011.994 Myocardial Infarct Size in Rats," Circulation 89(3):1282-1290, 1994 - LOR-10277 Berger, J., Wynder, E.L., "The Correlation of Epidemiological Variables," J. 00/00/1994 Clin Epidemiol, 47(8), 941-952, 1994 LOR-10278 Eysenck, H.J., "Does Smoking Really Kill Anybody?," Psychological Reports, 00/00/1995 77, 1243-1246 (1995) LOR-10279 Matanoski, G., et al., "Characteristics of Nonsmoking Women in NHANES I 00/00/1995 and NNANES I Epidemiologic Follow-Up Study with Exposure to Spouses - Who Smoke," American Journal of Epidemiology, 142(2), 149-157 (1995) = LOR-10281 Witschi, H., Espiritus, I., Peake, J.L., Wu, K., Maronpot, R.R., Pinkerton, K.E., 00/00/1997 "The carcinogenicity of environmental tobacco smoke," Carcinogenesis, 18(3), 575-586,1997 LOR-10330 Charleston Daily Mail, October 19, 1945, p. 4, "Some Facts About Smoking," " 10/19/1945 by Dr: George W. Crane LOR-10331 Charleston Daily Mail, March 28, 1948, p. 7, "Women's Smoking Receives 03/28/1948 " Blame In Coronary Thrombosis Increase" OR-10332 _ Charleston Daily Mail, July 16, 1948, p. 20, "Cancer of Lung Increases As 07/16/1948 Cigarette Sales Climb" LOR-10333 Charleston Daily Mail, April 26, 1949, p. 16, "The Worry Clinic: When the 04/26/1949 Women Smoke," by Dr. George W. Crane LOR-10334 ' Charleston Daily Mail, October 17, 1950; p. 9, "Smoking Produces III.Effects," 10/17/1950 by William Brady, M.D. LOR-10335 Charleston Daily Mail, September 26, 1951, p. 16, "Excessive,Smoking Is 09/26/1951 Usually The Cause of Buerger's Disease," by William Brady, M.D. LOR-10336 Charleston Daily Mail, December 10, 1952„ p. 20, "Tobacco Listed As Cause 12/10i1952 of Artery Damage" LOR-10337 Charleston Daily Mail, April 13, 1953, p. 16, "Tars From Cigarette Smoke 04/13/1953 Cause Skin Cancers In Mice" LOR-10338 Charleston Daily Mail, October 6, 1953, p. 16, "Cigarette Makers Asked To 10106/1953 Finance Cancer Research" LOR-10339 Charleston Daily Mail, November 11, 1954, p. 17, "Report On Cigarettes' Link 1 1 /1 111 954 To Heart Attacks Recalled" LOR-10340 Charleston Daily Mail, February 6, 1956, p. 13, "80 Pct. Of Mail Lung Cancer 02/06/1956 Laid To Cigarette Habit" LOR-10341 Charleston Daily Mail, March 22, 19_ 57, p. 15, "Unreleased Report Puts Certai 03/22/1957 Link In Cancer, Smoking" LOR-10342 Charleston Daily Mail, June 4, 1957, p: 1, "Cancer Study Links Cigarette 06/04/1957 Smoking With Earlier Death" OR-10343 Charleston Daily Mail, October 9, 1959, p. 11, "Doctor Believes Smoking 10/09/1959 Mothers' Babies Smaller" Page 12 of 79 98287934
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Exhibit Description: Document Name: Date: LOR-10045 Fisher, E.B., et al., "Smoking and Smoking Cessation," American Rev Respir 00/00/1990 Dis 142:702 (1990) OR-10048 Fletcher, G.F., et al., "Exercise Standards. A Statement for Health 00/00/1990 Professionals from the American Heart Association," Circ. 82:2286 (1990) LOR-10052 Freund, K.M., et al., "The Health Effects of Smoking, The Framingham Study: 07/00/1993 34 Years of Follow-Up," Ann. Epidemiol. 3(4):417-424, July 1993 LOR-10054 Furberg, C.D., et al., "Task Force 2. Clinical Epidemiology: The Conceptual 00/00/1996 Basis for Interpreting Risk Factors," JACC 27(5): 976-978. (1996) LOR-10055 Glantz, S.A. and Parmley, W.W., "Passive Smoking and Heart Disease: 04/05/1995 Mechanisms and Risk," JAMA 273(13):. 1047-1053, April 5, 1995 LOR-10056 Glikksman, M.D., et al., "Should the Primary Prevention of Coronary Heart 00/00/1987 Disease Commence in Childhood," Medical Journal of Australia 146: 360-362, 1987 LOR-10058 Gordon, T., et al.; "Death and Coronary Attacks in Men After Giving Up 00/00/1974 Cigarette Smoking," The Lancet 2(7893):1345-1348, 1974 LOR-10059 Gori, G.B., "Environmental Tobacco Smoke and Coronary Heart Syndromes: 00/00/1995 Absence of an Association," Regulatory Toxicology and Pharmacology 21(2): 182-295, 1995 - LOR-10063 Haapaniemi, H., et al:, "Lifestyle-Associated Risk Factors for Acute Brain 00/00/1997- Infarction Among Persons of Working Age," Stroke 28(1)::26-30 (1997) LOR-10064 Hale, W.E., et al., "Epidemiology of Intermittent Claudication: Evaluation of 00/00/1988 Risk Factors,".Age and Aging 17(1): 57-60. (1988) LOR-10065 Hammond, E.C., "Smoking in Relation to the Death Rates of One Million Men and Women," National Cancer Institute monograph #19, p. 127 LOR-10066 Hart, R.G., et al., "What's New in Stroke?" Texas Medicine 91(5): :46-55. . 00/00/1995 (1995) LOR-10067 Hayward, R.S.A, et al., "Preventive Care Guidelines: 1991," Anal Int Med . 00/0011991 114:758 (1991) LOR-10069 Hennekens, et al., "Epidemiology in Medicine," Little Brown and Company 00/00/1987. 1987 LOR-1 0071 Hoeg, J.M., "Evaluating Coronary Heart Disease Risk: Tiles in the: Mosaic," , 00/00/1997 JAMA 277 (17): 1387-1390. (1997) LOR-10072 Holme, I., et al., "Smoking and Atherosclerotic Disease. The Oslo'Study," Atherosclerosis VI Proceedings of the Sixth International Symposium, 883-887 LOR-10075 "IVth Worfd Conference on Lung Cancer," Chest 89 (1986) . 00/00/1986 LOR-10076 Jacobs, D.R., et al., "Cigarette Smoking and Mortality Risk. . Twenty-Five Year 00/00/1999 Follow-Up of the 7 Countries Study," Arch in Med 159:733 (1999) LOR-10077 Kahn, H.A., "The Dorn Study of Smoking and Mortality Among Us.Veterans," .. National Cancer Institute monograph #19, p. 1 LOR-10078 Kannel, W.B., "An Overview of the Risk Factors for Cardiovascular Disease," . 00/00/1983 Prevention of Coronary Heart Disease: Practical Management of the Risk Factors; Chapter 1, 1-19, 1983 LOR-10079 Kannel, W.B., "Silent Myocardial Ischemia and Infarction: Insights from the 11/00/1986 Framingham Study," Cardiology Clinics, Vol. 4; No. 4, November 1986 LOR-10080 Kannel, W.B., "Update on the Role of Cigarette Smoking in Coronary Artery 03/00/1981 Disease," Am Heart J, March 1981 LOR-10081 Kaplan, G,.A. and Keil, J.E., "Socioeconomic Factors and Cardiovascular 00/00/1993 Disease: A Review of the Literature," Circulation 88(4, Part 1): 1979-1998. (1993) Page 2 of 79 98287924 1
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Exhibit Description: Document Name: Date: LOR-10215 Katzenstein, A.W., "Environmental tobacco smoke and lung cancer risk: 00/00/1992 epidemiology in relation to confounding factors," Environment International 18:341-345 (1992) LOR-10216 Knekt, P., et al., "Elevated lung cancer risk among persons with depressed 00/00/1996 mood," American Journal of Epidemiology 144(12):1096-1103 (1996) LOR-10217 Kohlmeier, L., et al., "Pet birds as an independent risk factor for lung cancer: 00/00/1992 Case-control study," British Medical Journal 305:986-989 (1992) LOR-10218 Koo, L.C., et al., "Measurements of passive smoking and estimates of lung 00/00/1987 cancer risk among nonsmoking Chinese females," Int. J. Cancer 39:162-169, 1987 LOR-10219 Kritz, H., et al., "Passive smoking and cardiovascular risk," Archives of Internal 00/00/1995 Medicine 155:1942-1948 (1995) LOR-10220 La Vecchia, C., et al., "Passive Smoking and the Risk of Acute Myocardial 00/00/1993 Infarction," The Lancet 341(8843):505-506, 1993 LOR-10221 Lam, T.H., Cheng, K.K., "Passive smoking is a risk factor for lung cancer in 0 0/0 011 9 8 8 never smoking women in Hong Kong," In: Aoki, M., Hisamichi, $., Tominaga, S., eds. Smoking and Health 1987. Amsterdam: Excerpta Medica, Elsevier Science Publishers, 279-281, 1988 LOR-10222 Lam, T.H., et al., "Smoking, passive smoking and histological types in lung 00/00/1987 cancer in Hong Kong Chinese women," Br. J. Cancer 56(5):673-678, 1987 LOR-10223 Layard; M.W., "Ischemic heart disease, lung cancer and spousal smoking in 08/00/1994 the National Mortality Followback Survey," Submission to OSHA [Docket No. H-122], August 1994 LOR-10224 Layard, N.W., "Ischemic heart disease and spousal smoking in the National 0 0/0 011 9 9 5 Mortality Followback Survey," Regulatory Toxicology and Pharmacology 21:180-183 (1995) LOR-10225 Lee, P.N., "Environmental tobacco smoke and mortality," Karger, Basel, 1992 00/00/1992 LOR-10226 Lee, P.N., et al., "Relationship of passive smoking to risk of lung cancer and 0 0/0 011 9 8 6 other smoking-associated diseases," Br. J. Cancer 54:97-105 (1986) LOR-10228 LeVois, M.E. and Layard, M.W., "Inconsistency between workplace and 00/00/1994 spousal studies on environmental tobacco smoke and lung cancer," Regulatory Toxicology and Pharmacology 19:309-316 (1994) LOR-10229 Liu, Q., Sasco, A.J., Riboli, E., Hu, M.X., "Indoor air pollution and lung cancer 00/00/1993 in Guangzhou People's Republic of China," Am. J. Epidemiol. 137(2):145-154, . 1993 LOR-10230 Loscutoff, S., et al., "Dosimetry and Cardiopulmonary function in Rats . 00/00/1982 Chronically Exposed to Cigarette Smoke," Toxicol Appl Pharmacol 64:335-352 (1982) LOR-10231 Lui, Z., He, X., Chapman, R.S., "Smoking and other risk factors for lung cance 00/00/1991 in Xuanwei, China," Int. J. Epidemiol. 20(1):26-31, 1991 LOR-1 0232 Mettlin, C., "Milk drinking, other beverage habits, and lung cancer risk," Int. J. 0 0/0 011 9 8 9 Cancer 43:608-612 (1989) - LOR-1 0233 Modigh, C., et al., "Pet birds and risk of lung cancer in Sweden: a case-control 00100/1996 study," British Medical Journal 313:1236-1238 (1996) LOR-10234 Mukherjee, S., et al., "The Effect of Mainstream and Sidestream Cigarette 00/00/1993 Smoke Exposure on Oxygen Defense Mechanisms of Guinea Pig Erythrocytes," J Biochem Toxicology 8(3):119-125 (1993) 9 Page 9 of 79 98287931
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Exhibit Description: Document Name: Date: LOR-10474 Charleston Gazette, August 8, 1966, p. 19, "$25,213 U.S. Grant - WVU to 08/08/1966 Take Part In Cigarette Drive" OR-10475 Charleston Gazette, July 21, 1967, p. 38, "Lung Cancer Increases In State" 07/21/1967 LOR-10476 Charleston Gazette, July 27, 1967, p. 8, "Antismoking Books, Films On Hand, 07/27/1967 Free" LOR-10477 Charleston Gazette, September 12, 1967, p. 2, "Kennedy To Submit Bans - 09/12/1967 Smoking Cancels Out Life Advances, Expert Asserts," by Morton Mintz LOR-10478 Charleston Gazette, September 14, 1967, p. 14, "Smoking Peril Is Labeled 09/14/1967 Fact," by Morton Mintz LOR-10479 Charleston Gazette, December 8, 1967, p. 23, "Emphysema Rise Tied To 12/08/1967 Smoking" LOR-1 0480 Charleston Gazette, June 14, 1968, p. 27, "Smoking Dangers Borne Out" : 06/14/1968 LOR-10481 Charleston Gazette, August 7, 1968, p. 11, "Cigarette Hazard Worse In 08/07/1968 Kanawha" LOR-10482 Charleston Gazette, August 20, 1968, p. 11, "31 Millions Packs Last Year- 08/20/1968 Smoking Constant in County" LOR-10483 Charleston Gazette, September 4, 1968, p. 14, "State Notes Increasing Lung 0910411968 Cancer," by Edward Peeks LOR-10484 Charleston Gazette, November 13, 1968, p. 13, "'Most Important Factor - 11/13/1968 'Black Lung' Laid Mostly to Smoking," by Edward Peeks LOR-10485 Charleston Gazette, July 29, 1969, p. 2, "New Report Underlines Cigarette 07/29/1969 Smoke Peril - Finch Applauds End of Advertising" LOR-10486 Charleston Gazette, July 28, 1970, p. 5, Cartoon, "Cigarettes Are Killers That 07/28/1970 Travel in Packs" LOR-10487 Charleston Gazette, May 17, 1971, p. 10, "Smoking Can Hurt Unborn Baby" 05/17/1971 OR-10488 Charleston Gazette, December 22, 1971, p. 6B, "Smoking Emerges as World 1 2/2 211 9 7 1 Problem," by Frank Carey LOR-10489 Gazette/Mail, Jahuary 16, 1972, p. 4M, "Big Day in the Tobacco Barn" 01/16/1972 LOR-10490 Charleston Gazette, April 8, 1972, p. 11A, "Stop Smoking Clinic Scheduledin 04/08/1972 Jackson" LOR-10491 Charleston Gazette, January 9, 1973, p. 3B, "'No Smoke Day' To Be 01/09/1973 Observed" LOR-1 0492 Charleston Gazette, February 5, 1973, p. 11A, "Smoking-Related Diseases . 02/05/1973 Climb" LOR-10493 Charleston Gazette-Mail, March 24, 1974, p. 4A, "Smoking Hurts All of Health" 03/24/1974 LOR-10494 Charleston Gazette-Mail, March 31, 1974, p. 11B, "Smoking in Pregnancy 03/31/1974 Risks Baby's Health," by Marion Wells LOR-1 0495 Charleston Gazette, September 1, 1974, p. 3B, "Course Urges Health Habits," 09101/1974 by Kay Michael LOR-1 0496 Charleston Gazette, January 4, 1975, p. 5A, "Antismoking Clinic Planned" 01/04/1975 LOR-1 0497 Charleston Gazette, January 5, 1975, p. 13C, "Cigarette 'Agents' Doomed?" 01/05/1975 LOR-10498 "Smoking Can Affect Unborn Offspring" LOR-10499 Charleston Gazette, January 16, 1977, p. 2E, "Letters to the Editor: Smoke 01/16/1977 Effects" LOR-10500 Charleston Gazette, March 7, 1977, p. 6A, "Enjoy Smoking?" 03/07/1977 LOR-10501 Charleston Gazette, September 29, 1977, p. 13A, "Half of Bladder Cancer in 09/29/1977 Men Caused by Smoking Study Says" Page 18 of 79 98287940
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Exhibit Description: Document Name: Date: LOR-10133 Stokes, J., et al., "The Relative Importance of Selected Risk Factors for 00/00/1987 Various Manifestations of Cardiovascular Disease.Among Men and Wonien ! from 35 to 64 Years Old: 30 Years of Follow-Up in the Framingham Study," Circ. 75(Suppl. V): V-65-73 (1987) LOR-10136 "The Canadian Guide to Clinical Preventive Health Care," The Canadian Task 00/00/1998 Force of Periodic Health Examination 1998 LOR-10137 "The Health Benefits of Smoking Cessation," Report of the Surgeon General 00/00/1990 1990 1 LOR-10138 "The Health Consequences of Smoking," A Report of the Surgeon General 00/00/1982 1982 LOR-10139 "The Heart, Arteries and Veins Xlllth Edition," Editors Robert C. Schlant, et al. LOR-10141 Thompson, M.M., et al. "Heart Disease Risk Factors, Diabetes, and Prostatic 00/0011989 Cancer in an Adult Community," American Journal of Epidemiology 129(3): 511-517 (1989) LOR-10142 Thornton, A., et al.,•"Differences Between Smokers, Ex-Smokers, Passive 00/00/1994 Smokers, and Non-Smokers," Journal of Clinical Epidemiology 47(10): 1143- 1162 (1994) - LOR-10144 Tockman, M.S., et al., "Sensitive and Specific MonoclonalAntibody 00/00/1988 Recognition of Human Lung CancerAntigen," J Clin Onc 6:1685'(1988) LOR-10145 Tunstall-Pedoe, et al., "Contribution of Trends and Survival and Coronary 00/00/1999 Event Rates: Ten Year Results from 37 WHO MONICA Project Populations," Lancet 353:1547 (1999) LOR-10146 Tuomilehto, J., et al., "Decline in Cardiovascular Mortality in North Karelia," 00/00/1986 Brit Med J 293:1068 (1986) OR-10148 Wexler, L., et al., "Coronary Artery Calcification: Pathophysiology, - 00/00/1996 Epidemiology, Imagining Methods and Clinical Implications," (AHA Medical/Scientific Statement), Circ 94:1175 (1996) LOR-10149 WHO MONICA Project, "Assessing CHD Mortality and Morbidity;" Inter J Epid 00/00/1989 18:538 (1989) LOR-10150 WHO MONICA Project, "Objectives and Design," Inter J Epid' 18:29 (1989) 00/00/1989 LOR-10151 WHO MONICA Project, "Heart Disease: Good and Bad News;" Press release 08/24/1998 (Aug. 24, 1998) LOR-10152 Willett, W.C., et al., "Relative and Absolute Excess Risks of Coronary Heart 00/00/1987 Disease Among Women Who Smoke Cigarettes," New England J of Med. 317(21): 1303-1309 (1987) LOR-10153 _ Williams, R.B., "Lower Socioeconomic Status and Increased Mortality: Early 06/03/1998 Childhood Roots and the Potential for Successful Intervention," JAMA 279(21):1703-1708, June 3, 1998 LOR-10154 Wilson, P., et al., "Prediction of Coronary Heart Disease Using-Risk Factor 0511211998 Categories," Circ.97:1837-1847, May 12, 1998 LOR-10155 Winkleby, M.A., et al., "Social Class Disparities in Risk Factors For Disease: 00/00/1990 Eight-Year Prevalence Patterns by Level of Education," Preventive Medicine 19:1-12 (1990) LOR-10156 Winkleby, M.A., et al., "Socioeconomic Status and Health: How Education, 00/00/1992 Income, and Occupation Contribute to Risk Factors for Cardiovascular Disease," American Journal of Public Health 82(6): 816-820 (1992) LOR-10157 Wolf, P.A., et al., "Probability of Stroke: A Risk Profile From the Framingham 0010011991 Study," Stroke 22: 312-318 (1991) ~ - 98287927 Page 5 of 79
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Exhibit Description: Document Name: Date: LOR-10235 Muscat, J.E. and Wynder, E.L., "Exposure to Environmental Tobacco Smoke 00/00/1995 and the Risk of Heart Attack," International Journal of Epidemiology 24(4):715- 719,1995 LOR-10236 Penn, A., Snyder, C.A., "Inhalation of Sidestream Cigarette Smoke 00/00/1993 Accelerates Development of Arteriosclerotic Plaques," Circulation 88(4, Part 1):1820-1824, 1993 LOR-10237 Penn, A., et al., "Inhalation of Steady-State Sidestream Smoke from One 00/00/1994 Cigarette Promotes Arteriosclerotic Plaque Development," Circulation 90(3):1363-1367, 1994 LOR-10238 Penn, A., Snyder, C.A., "1,3 Butadiene, A Vapor Phase Component of 00/00/1996 Environmental Tobacco Smoke, Accelerates Arteriosclerotic Plaque Development," Circulation 93(3):552-557, 1996 . LOR-10239 Pershagen, G., et al., "Passive smoking and lung cancer in Swedish women," 00/00/1987 Am. J. Epidemiol. 125(1):17-24, 1987 LOR-10240 Phelps, D.W., et al., "Tobacco smoke inhalation studies: a.dosimetric 00/00/1984 comparison of different cigarette types," Archives of Environmental Health 39(5):359-363 (1984) LOR-10241 Potter, J.D., et al., "Alcohol, beer, and lung cancer in postmenopausal women: 00/00/1992 The Iowa Women's health study," Annals of epidemiology 2(5):587-595 (1992) LOR-10242 Rajini, P., et al., "Decreased Fetal Weights in Rats Exposed to Sidestream 00/00/1994 Cigarette Smoke," Fundamental and Applied Toxicology 22:400-404, 1994 LOR-10243 Rajini, P., Witschi, H., "Short-Term Effects of Sidestream Smoke on 00/00/1994 Respiratory Epithelium in Mice: Cell Kinetics," Fundamental and Applied Toxicology 22:405-410 (1994) LOR-10244 Raymond, T.L., et al., "Failure of Chronic Cigarette Smoke Exposure to Alter 00/00/1982 Plasma Lipoproteins of Stumptailed Macaques (Macaca Arctoides)," Atherosclerosis 41:27-33 (1982) LOR-10245 Riegelman, R.K. and Hirsch, R.P. "Studying a study and testing a test. How to 00/00/1996 read the health science literature," Little, Brown and Co., Boston, 1996 - LOR-10246 Rogers, W.R., et al., "Cigarette Smoking, Dietary Hyperlipidemia, and 00/00/1988 Experimental Atherosclerosis in the Baboon," Experimental and Molecular Pathology 48:135-151 (1988) LOR-10247 Rylander, R., et al., "Lung cancer, smoking and diet among Swedish men," 00/00/1996 Lung Cancer 14(Suppl. 1):S75-S83 (1996) LOR-10248 Shimizu, H., et al., "A case control study of lung cancer in nonsmoking 00/00/1988 women," Tohoku J. Exp. Med., 154(4):389-398 (1988) LOR-10249 Sindhu, R.K., et al., "Effect of Environmental Tobacco Smoke on the 00/00/1995 Metabolism of (-)-Trans-Benzo[a]pyrene-7,8-Dihydrodiol in Juvenile Ferret Lung and Liver," Journal of Toxicology and Environmental Health, 45:453-464 (1995) LOR-10250 Sobue, T:, et al., "Passive smoking among nonsmoking women and the 00/00/1990 relationship between indoor air pollution and lung cancer incidence -- results o a multicenter case controlled study," Gan To Rinsho, 36(3):329-333 (1990) LOR-10251 Steenland, K., "Passive smoking and the risk of heart disease," JAMA 00/00/1992 267(1):94-99 (1992) LOR-10252 Steenland, K., et al., "Environmental tobacco smoke and coronary heart 00/00/1996 disease in the American Cancer Society CPS-II cohort," Circulation 94(4):622- 628 (1996) _ Page 10 of 79 98287932
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Exhibit Description: Document Name: Date: LOR-10784 Publication entitled "Plasma Nicotine Levels After Smoking Cigarettes with 05/24/1975 High Medium and Low Nicotine Yields," M.A.H. Russell, et al., British Medical Journal, Vol. 24, pp. 414-416, May, 1975 LOR-10785 Publication entitled "Establishing a Nicotine Threshold for Addiction," N. 07/14/1994 Benowitz, New England Journal of Medicine, Vol. 331, No. 2, pp. 123-125, July 14, 1994 LOR-10786 Letter from D. Sauers to R. Smith regarding Consumer Reports Article "Less 04/26/1976 Tar, Less Nicotine: Is that Good?" LOR-10787 Minutes of Meeting: NCI Smoking & Health Program High Nicotine/Tar; Low 05/05/1976 Tar Cigarettes LOR-10788 Minutes of Meeting: NCI Smoking and Health Program, Workshop on 02/0511976 Organoleptic and Acceptability Characteristics of Less Hazardous Cigarettes LOR-10789 Memorandum from J.M. Johnson to M.A. Sudholt regarding "Statistical 07/24/1996 Evaluation of the Effects of Ammonium Carbonate, Ammonium Bicarbonate, Urea and Diamonium Phosphate on Smoke pH, Smoke Data and Leaf Chemistry" LOR-10790 Memorandum from J.M. Johnson to M.A. Sudholt regarding "Summary of the 09/18/1996 Effects of Ammonium Carbonate, Ammonium Bicarbonate, Urea and Diamonium Phosphate on Smoke pH, Smoke Data and Leaf Chemistry" LOR-10791 Memorandum from R.T. Walker to M.A. Sudholt regarding "The Effect of 03/01/1996. Diammonium Phosphate (DAP) on Smoke pH and Nicotine Delivery" LOR-10792 27 CFR Ch. 1, Part 20, "Distribution and Use of Denatured Alcohol and Rum." (Excerpts) LOR-10793 Memorandum from A.B. Hudson to R. Smith regarding "Expert Terminology fo 11/02/1973 Impact and Strength" OR-10794 Memorandum from S.T. Jones and C.W. Lassiter to A.W. Spears regarding 07/08/1970 "R.L. Improvement' LOR-10795 Memorandum from T..Moring to C.L. Tucker regarding "Improvement to the 11/01/1972 _ Physical Properties of Our Present Reconstituted Leaf' LOR-10796 0796 Memorandum from T. Moring to C.L. Tucker regarding "Transfer of Nicotine 0 6/1 411 9 7 7 from Cut Tobacco to RL" LOR-10797 Report from T. Moring to C.L. Tucker regarding "Improvement of the Smoking 04/03/1973 Quality of Our Present Reconstituted Leaf Product" LOR-10798 Memorandum from A.B. Hudson to C.W. Kelley regarding "Organoleptic 09/28/1974 Correlation of Burley Tobacco" LOR-10799 Publication entitled "Fraction of Protonated and Unprotonated Nicotine in 00/00/1972 Tobacco Smoke at Various pH Values," G.P. Morie, Tobacco Science, Vol. 16, 1972 LOR-10800 Letter to Subcommittee on Health and the Environment regarding information 05/24/1994 requests (from A.J. Stevens to H.A. Waxman) LOR-10801 Letter from Subcommittee on Health and the Environment regarding 05/25/1994 information requests (from H.A. Waxman to A.H. Tisch) LOR-10802 Letter to Subcommittee on Health and the Environment regarding information 06/17/1994 requests (from J. Rupp to R. Forbes and W. Schultz) LOR-10803 Letter from Subcommittee on Health and the Environment.regarding 09/28/1994 information requests (from H.A. Waxman to A.H. Tisch) LOR-10804 Letter from Subcommittee on Health and the Environment regarding 09/30/1994 information requests (from H.A. Waxman to A.H. Tisch) Page 30 of 79 98287952 ,
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Exhibit Description: Document Name: Date: LOR-10502 Charleston Gazette, October 8, 1977, p. 4A, "Subsidy for Tobacco Height of 10/08/1977 Absurdity" OR-10503 Charleston Gazette, November 13, 1977, p. 1, "Cigarette Smoking" . 11/13/1977 LOR-10504 Charleston Gazette, November 14, 1977, p. 1, cont'd. 16,-"Congressmen 11/14/1977 Favor Tobacco Subsidy" LOR-10505 Charleston Gazette-Mail, August 6, 1978, p. 11 B, "14-Year Smoking Study 08/06/1978 Confirms Health Hazard" LOR-10506 Sunday Gazette-Mail, January 28, 1979, p. 3M, "Smoking: 01/28/1979 Point/Counterpoint" LOR-10507 Charleston Gazette, May 25, 1979, p. 3B, "Smoking Harmful to Fetus" ! 05/25/1979 LOR-10508 Charleston Gazette, January 13, 1980, p. 14D, "Tobacco Harms Unborn," by 01/13/1980 Dr. Bill R. Carlton LOR-10509 Charleston Gazette, July 12, 1981, p. 9C, "Going up in smoke," by Jane.E. 07/12/1981 Brody LOR-10510 Charleston.Gazette, May 2, 1982, p. 2C, "Cancer's best ally" 05/02/1982 LOR-10511 Charleston Gazette, December 19; 1982, p. 9B, "Smoking harms immune 12/19/1982 system" LOR-10512 Charleston Gazette, May 24, 1984, p. 13A, "'Smoke-free'society surgeon . 05/24/1984 general's goal" LOR-10513 Charleston Gazette, September 19, 1984, p. 5B, "Epcot Poll" . 09/19/1984 LOR-10514 Charleston Gazette, November 25, 1984, p. 2D, "Anti-fag evidence" 11/25/1984 LOR-10515 Charleston Gazette, May 24, 1985, p. 5A, "Smoking found to increase risk of 05/24/1985 heart attack in women" LOR-10516 Charleston Gazette, August 8, 1985, p. 3A, "Lung cancer deaths up for wome 08/08/1985 over 55" . OR-10517 Charleston Gazette, September 22, 1985, p. 2C, "Tobacco toll" 09/22/1985 LOR-10518 Charleston Gazette, November 26, 1985, p. 6, "Health Line tapes offer . 11/26/1985 information on smoking" LOR-10519 Charleston Gazette, December 11, 1985, p. 8, "Pamphlet explains dangers of 12/11/1985 smoking during pregnancy" LOR-10520 Sunday Gazette-Mail, January 12, 1986, p. 9A, "Tobacco kills more adults 01/12/1986 than war," by Jan Ziegler - LOR-10521 Charleston Gazette, June 18, 1986, p. 10B, "VWU to implement strict smoking 06/18/1986 policy" LOR-10522 Charleston Gazette, January 30, 1986, p. 5A, "Americans living to almost 75; 01/30/1986 lung cancer deaths highest ever" . LOR-10523 Charleston Gazette, November 15, 1986, p. 16A, 'Women physicians begin-. 11/15/1986 push to end smoking-related deaths," by Nadine Brozan LOR-10524 . Charleston Gazette, December 31, 1976, p. 9A, "Cigarettes Puffed More Than 12/31/1976 Ever" - - LOR-10525 Charleston Gazette, April 27, 1956, p. 35, "Many Lean to Overindulgences To 04/27/1956 Satisfy Emotional Hungers," by.David M. Cleary LOR-10526 Charleston Gazette, May 17, 1956, p. 31,"Dennis the Menace" 05/17/1956 LOR-10527 Charleston Gazette, July 13, 1957, p. 12, "Cigarette Craving'Curbs' 0 711 3/1 9 57 Suggested" LOR-10528 Charleston Gazette, November 16, 1977, p. 1, "The Deadly Habit" 11/16/1977 LOR-10529 Charleston Gazette, October 11, 1985, p. 56, "Brynner dies, gives smokers 10/11/1985 warning" Page 19 of 79 98287941
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Exhibit Description: Document Name: Date: LOR-10554 Public Service Announcements Video LOR-10555 CD - Smoke! Smoke! Smoke! (That Cigarette) by Tex Williams, 1947 00/00/1947 OR-10556 "Overview - Health Consequences of Smoking," U.S. Department of Health, 00/00/1975 Education, and Welfare, The Health Consequences of Smoking: 1975, Surgeon General Report,1975, p. 3 LOR-10558 "Causal Inference in Epidemiology," Kenneth J. Rothman,-Modern Epidemiology, pp. 16-21 LOR-10559 "Epidemiology Faces its Limits," Gary Taubes, Science, Vol. 269, pp. 164-169, 07/14/1995 July 14, 1995 LOR-10560 "Nature of the Activity/Health Relationship: Causality; Population Burden of 00/00/1996 Sedentary Living," Physical Activity and Health: A Report of the Surgeon General, Surgeon General Report, 1996, pp. 144-150 LOR-10561 "Causal Inference in Epidemiology," Kenneth J. Rothman, -Modern Epidemiology, pp. 12-17 LOR-10562 "Atherosclerosis: International Journal for Research and Investigation on 00/00/1981 Atherosclerosis and Related Diseases," C.W.M. Adams, et al., pp. 1-52, 1981 LOR-10563 "A Strengthening Programme for Weak Associations," Kenneth J. Rothman, et - al., International Journal of Epidemiology, Vol. 17, No. 4 (Suppl.), pp. 955-959 LOR-10564 "Basic Concepts in the Assessment of Risk," James J. Schlesselman, Ph.D., et al., Monographs in Epidemiology and Biostatistics: Case-Control Studies: Design, Conduct, Analysis, Chapter 2, pp. 27-67 LOR-10566 "Privilege and Health - What is the Connection?," Marcia Angell, M.D., The 07/08/1993 New England Journal of Medicine, Vol. 329, No. 2; pp. 126-127, July 8, 1993 LOR-10567 "Passive Smoking Doesn't Cause Cancer - Official," Victoria MacDonald, The 03/08/1998 Sunday Telegraph Limited, March 8, 1998 OR-10568 "Preface," ICD-9-CM Code Book for Physician Payment, Volumes 1& 2, p. v, 00/00/1997 Fifth Edition, 1997 LOR-10569 Cummings Exhibit No. 25, State of Texas v. The American Tobacco Company, 09/28/1997 et al., No. 5-96CV91, September 28, 1997 LOR-10570 Epidemiology in Medicine, First Edition, pp. 3-5, 38-45, 50-53 (1987) 00/00/1987 LOR-10571 Cancer Epidemiology and Prevention, Basic Concepts - 20 (Practical Causal 00/00/1982 Inference); Causation and Causal Inference - 21 (Analogy), David - Schottenfeld, M.D., et al., 1982 LOR-1 0572 "Epidemiology Spreads Disinformation," (Editorial), G. Zajicek, The Cancer 09/00/1992- Journal, Vol. 5, No. 5, September-October, 1992 10/00/1992 . LOR-10573 "Sampling Methods for Random Digit Dialing," Joseph Waksberg, Journal of 03/00/1978 the American Statistical Association, Vol. 73, No. 361, pp. 40-46, March, 1978 LOR-10574 "The Health Consequences of Smoking: Cancer; A Report of the Surgeon 00/00/1982 General," Surgeon General Report, 1982, pp. 16-17, 20-21 LOR-10575 "Inferring Causal Connections - Habit, Faith or Logic?," Kenneth J. Rothman, Causal Inference, pp. 3-12 LOR-10577 "Controlling the Avoidance Causes of Cancer: Needs and Opportunities for 11/00/1995 Etiologic Research," Jonathan M. Samet, Ph.D., Environmental Health Perspectives, Vol. 103, Supplement 8, pp. 307-311, November, 1995 LOR-10579 "Socioeconomic Factors, Health Behaviors, and Mortality: Results from a 06/03/1998 Nationally Representative Prospective Study of US Adults," Paula M. Lantz, Ph.D., et al., JAMA, Vol. 279, No. 21, pp. 1703-1708, June 3, 1998 OR-10580 "Attributable Risk," Abraham M. Lilienfeld, M.D., et al., Foundations of 00/00/1980 Epidemiology, Second Edition, p. 217; 1980 Page 20 of 79 98287942
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Exhibit Description: Document Name: Date: LOR-10833 Annual Review; 1975 Research Department by H.J. Minnemeyer 04/30/1976 LOR-10834 Letter from J.E. Sammons to H. Kornagay regarding AMA-ERF 04/19/1977 OR-10835 Award/Contract Between USDA and Lorillard for Sample Cigarettes 07/25/1979 LOR-10836 Letter from E.C. Hammond (American Cancer Society) to H.B. Parmele 12/18/1962 regarding development of law tar/nicotine cigarette LOR-10837 Letter from K.M. Endicott (NCI) to M. Yellen regarding Dr. Spears providing 03/20/1968 advice to Lung Cancer Task Force LOR-10838 Letter from K.M. Endicott to Senator Magnuson informing him of interesfof P.. 03/22/1968 Lorillard Company in providing scientific expertise to the Lung Cancer Task Force LOR-10839 Letter from A.W. Spears to K.M. Endicott accepting an invitation to serve as a- 03/28/1968 member of the Less Hazardous Cigarette Working Group LOR-10840 Publication entitled "Personality and Smoking Behavior," C.D. Spielberger, et 0 0100/1 9 8 2 al., Journal of Personality Assessment, Vol. 46, pp. 396-403, 1982 LOR-10841 Publication entitled "On the relation between family smoking habits and the 00/00/1983. smoking behavior of college students," C.D. Spielberger, et al., International Review of Applied Psychology, Vol. 32, pp. 53-69, 1983 LOR-10842 Report regarding "How Far Do Smokers Stick Cigarettes in Their Mouths?" J. : 06/07/1977 Meyers, et al. LOR-10843 Report regarding "Personality Smoking Behavior," C.D. Spielberger, et al. :. 06/19/1981 LOR-10844 Letter from M. Yellen announcing Lorillard's withdrawal from TI 05/03/1967 LOR-10845 Article entitled "Tars and Nicotine in Cigarettes: Report #5 in CU's Tests," 03/00/1958 Consumer Reports, pp.; 126-127, March 1958 LOR-10846 Article entitled "Tars and Nicotine in Cigarettes: Report #6 in CU's Continuing 04/00/1958 Tests," Consumer Reports, pp. 224-225, April 1958 OR-10847 Publication entitled "Coresta Smoking Study Group; A Thirty Port Smoking 00/00/1972. Machine for Continuous Smoke Generation," J.R. Wagner, et al., TCRC Program 1972. LOR-1 0848 Publication entitled "A Thirty-Port Smoking Machine for Continuous Smoke , 05/00/1975 Generation," F.J. Schultz, et al., Beitreage Zor Tabakforschung, Vol. 8, No. 2, May 1975 LOR-10849 Memorandum from F.J. Schultz to A.W. Spears regarding"Draft Response to 05/10/1983. FTC Request for Comments" LOR-10850 Memorandum from G.B. Gori regarding plans for new TWG projects 02/05/1971 LOR-10851 Report regarding "Chemistry and In Vitro Bioassay of Smoke from . 06/00/1976 Experimental Filter Cigarettes" LOR-1 0852 Table regarding "Properties of Candidate Less Hazardous:Cigarettes as .: 01/00/1976 Determined from the Smoking and Health Program Activities" LOR-10853 "Status Report Smoking and Health Program Division of Cancer Cause & 06/30/1974 Prevention National Cancer Institute" LOR-10854 Report regarding "Development of a Flavor System for Acceptability to 01/00/1977 Smokers of Candidate Less Hazardous Cigarettes - Final Report" from A.D. Little to Enviro Control Inc. LOR-1 0855 Contract information regarding A.D. Little's study "Development of a Flavor System for Acceptability to Smokers of Candidate Less Hazardous Cigarettes" LOR-10856 TWG Minutes of the Third Meeting held October 3 and 4, 1968 10/04/1968 LOR-10857 Minutes of the Tobacco Working Group Meeting NCI Smoking and Health 02119/1975 Program, February 18 and 19, 1975 Page 32 of 79 98287954
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Exhibit Description: Document Name: Date: LOR-10668 Memorandum from J.D. Heck regarding Status of Mouse Lymphoma 10/31/1984 Mutagenesis Assays - LOR-10669 Report regarding A Salmonella/Mammalian Microsome Mutagenicity Assay of 08/24/1976 Cigarette Tobacco Additives LOR-10670 Report regarding Artificial Cocoa by H.S. Tong 0711 4/1 9 8 1 LOR-10671 _ Letter from D.J. Brusick to H.J. Minnemeyer regarding mammalian in vitro 06/25/1984 mutagenesis testing LOR-10672 Publication entitled "Smoking and Lung Cancer; Report to the Sub-committee 00/00/1959 for the Study of the Risks of Cancer from the Air Pollution and the Consumption of Tobacco," R. Doll, Acta. Unio. Contra. Cancrum., 1959 LOR-10673 Publication entitled "Composition of Cigarette Smoke The Gaseous Phase," 07/00/1949 J.B. Fishel, Indust. and Engin. Chem., Vol. 41, p. 1374, July 1949 LOR-10674 Final Report by The Ohio State University Research Foundation, J.F. Haskins, 0710 811 94 9 "Study of Cigarette Smoke" LOR-10675 Publication entitled "Role of Tobacco Stems in the Formation of Nitrosamines 00/00/1983 in Tobacco and Cigarette Mainstream and Sidestream Smoke," K.D. Brunneman, et al., J. Agric. Food Chem., Vol. 31, p. 1221 LOR-10676 Letter from A.W. Spears to J.E. Bennett regarding Chemosol 12/08/1967 LOR-10677 Final Report: Cigarette Smoke Condensate Preparation and Dermal - 03/28/1973. Appiication to Mice by J.L. Gargus, et al. LOR-10678 A review of "Technical Report On Chemosol - A Fuel Additive For Cigarette Tobacco" LOR-10679 "Report on the'Chemosol' Process" LOR-10680 Report entitled "The Absorption of Cigarette Smoke by the Upper Respiratory 12/00/1964 System," by A.W. Spears OR-10681 Report entitled "A Survey of the Recent Work on the Cigarette Smoke Cilia 06/01/1964 Problem," by F.J. Schultz LOR-10682 Letter from J.M. Pilcher to H.B. Parmele enclosing final summary report on the 05/14/1965 development of filters to selectively remove cilia static components from . cigarette smoke LOR-10683 "Final Summary Report on Development of Filters to Selectively Remove 05/14/1965 Ciliastatic Components from Cigarette Smoke," G.W. Kinzer, et al. LOR-10684. Publication entitled "Differences in Ciliatoxicity of Cigarette Smoke 11/00/1967 Comparison of Two Exposure Methods," T. Dalhamn, et al., American Review of Respiratory, Vol. 90, No. 5, p. 1078, November 1967 LOR-10685 Letter from H.B. Parmele to T. Dalhamn regarding an invitation to evaluate: 10/17/1962 cilia inhibiting properties of cigarette smoke LOR-10686 Publication entitled "Cigarette Smoke and Ciliastasis," T. Dalhamn, et al., , 07/00/1966 Archives of Environmental Health, Vol. 13, pp. 47-50, July 1966 LOR-10687 Publication entitled "A Machine for Introducing a Regulated Amount of 0 0/0 011 96 3 Tobacco Smoke into an Animal," T. Dalhamn, et al., Int. Journal Air Wat. Poll., Vol. 7, pp. 511-515, 1963 LOR-10688 Letter.from H.B. Parmele to R.H. Roberts regarding research on plants and tar 02/04/1955 LOR-10689 Cigarette Modification Project Mission Statement LOR-10690 Report regarding Cigarette Modification Project LOR-10691 Manuscript submitted for publication entitled "Determination of Personal. 00/00/1998 r7 Exposure to Environmental Tobacco Smoke: Comparison of Salivary Cotinine Levels and Nicotine Exposure," R.A. Jenkins Page 24 of 79 98287946
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Lorillard Exhibits for Individual Personal Injury Cases G Page1of79 Description: Document Name: Date: OR-10001 Curriculum Vitae of David Guay Benditt, M.D. LOR -10002 Expert Witness Disclosure of David Guay Benditt, M.D. 0913011999 LOR-10018 "Assessment of cardiovascular risk by use of multiple-risk-factor assessment 00/00/1999 equations," American Heart Association Circulation at page 1481 (1999) LOR-10019 Anderson, K.M., et aL, "An Updated Coronary Risk Profit, A Statement for 01/00/1991 Health Professionals," Circulation, Vol. 83, No. 1, January 1991 LOR-10021 Balkau, B., et al., "Epidemiology of Peripheral Arterial Disease;" Journal of 00/00/1994 Cardiovascular Pharmacology 23(Supp. 3): S8-S16, 1994 LOR-1 0023 "Biomarkers: Medical and workplace applications," Joseph Henry Press 00/00/1998 (1998) LOR-10025 Braunwald, E., "Heart Disease: A Textbook of Cardiovascular Medicine," 5th Ed., Vol. 1 & 2 LOR-10026 Broad and Hall, "Joiners and Non-Joiners in Smoking Treatment," Add Behav 00/00/1984 9:217 (1984) LOR-10027 Brockie, R.E., et al., "Tobacco and Coronary Heart Disease: Risk Factors, 00/00/1990 Mechanisms of Disease, and Risk Modifications," Seminars in Respiratory Medicine 11(1):5-35, 1990 LOR-10028 Brundage, B.H., "Computed Tomography of the Heart," The Heart (9th Edition 00/00/1998 Chapter 18, pp. 623-640. (1998) LOR-10029 Carstensen, et al., "Mortality in Relation to Cigarette and Pipe Smoking," J 00/00/1987 Epid & Comm HIth;41 `.166 (1987) LOR-10030 Dembroski, T.M., et al., "A Social-Psychophysiological Model of Biobehavioral 00/00/1985 Factors and Coronary Heart Disease," Stress and Anxiety, Vol. 9, C.D., Hemisphere Publishing Corporation, New York, pp. 177-190. (1985) LOR-1 0031 Denollet J., "Biobehavioral Research on Coronary Heart Disease: Where is 00/00/1993 the Person?" Journal of Behavioral Medicine 16(2): 115-141, 1993 LOR-10032 "Did MONICA really say that?" Brit Med J 1998; 317:1023 (Editorial) . . 00/00/1998 LOR-10033 Doll and Peto, "Mortality in Relation to Smoking. Twenty Years Observations;" 00/00/1976 Brit Med J 2:1525 (1976) LOR-10034 Dormandy, J.A. and Loh, A., "Differential Diagnosis of Intermittent"Claudicatio 00/00/1992 and the Adequacy of Epidemiological Studies," Annales Chirurgiae at Gynascologiae 81(2): 112-114 (1992) LOR-10035 Dosman J.A., et al., "Obstructive Lung Diseases, Part I; Medical Clinics of 00/00/1996 North America" 1996; 80 LOR-10036 Ebrahim, S., Smith, G.D., "Systematic review of randomized controlled trials of 06/07/1997 multiple risk factor interventions for preventing coronary heart disease," BMJ, Vol. 314, June 7, 1997 LOR-10037 "Ecological Analysis of the Association Between Mortality and Major Risk 00/00/1994 Factors," Inter J Epid 23:50 (1994) LOR-10040 Eliot, R.S. and Morales-Ballejo, H.M:,-"The Heart, Emotional Stress, and Oo100/1994 Psychiatric Disorders," The Heart, Arteries and Veins, McGraw-Hill, Inc., New York, Chapter 117, pp. 2087-2097, 1994 LOR-10042 Doyle, J.T., et al., "Final Report of the Pooling Project," J Chronic Dis 31(4): 00/00/1978 201-207; 1978 LOR-10044 Fiore, et al., "Methods Used to Quit Smoking in the United States," JAMA 00/00/1990 263:2760 (1990) 98287923
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Exhibit Description: Document Name: Date: LOR-10176 Chan, W.C., Fung, S.C.., "Lung cancer in Non-smokers in Hong Kong," In: 00/00/1982 Grundmann, E., ed. Cancer Campaign, Vol. 6, Cancer Epidemiology, Stuttgart West Germany: Gustave Fisher Verlag, 199-202, 1982 LOR-10177 Correa, P., et al., "Passive smoking and lung cancer," Lancet, 2:595-597, 00/00/1983 1983 LOR-10178 Cress, R.D., et al., "Characteristics of women nonsmokers exposed to passive 00/00/1994 smoke;" Preventive Medicine 23:40-47 (1994) LOR-10179 Dobson, A.J., et al., "Passive Smoking and the Risk of Heart Attack or 00/00/1991 Coronary Death," The Medical Journal of Australia 154:793-797, 1991 LOR-10180 Du, Y.X., Cha, Q., Chen, Y.Z. and Wu, J.M.., "Exposure to environmental 00/00/1993 tobacco smoke and female lung cancer in Guangzhou, China," Indoor Air 1:511-516, 1993 LOR-10181 Finch, G., et al., "Failure of Cigarette Smoke to Induce or Promote Lung 00/00/1996 Cancer in the A/J Mouse," Cancer Letters 99:161-167, 1996 LOR-10182 Fisher, E., et al., "Cigarette Smoking and Cholesterol Atherosclerosis of 00/00/1974 , Rabbits," Arch Pathol 98:418-421, 1974 LOR-10183 Fontham, E.T.H., et al., "Environmental tobacco smoke and lung cancer in 0010011994 nonsmoking women," JAMA 271(22):1752-1759, 1994 LOR-10184 Fraser, G., et al., "Diet and Lung Cancer in California Seventh-day 00/00/1991 Adventists;" Am J Epidemiol 133(7):683-693, 1991 LOR-10185 Gairola, C., et al., "Mainstream and Sidestream Cigarette Smoke-Induced 00/00/1993 DNA Adducts in C7B1 and DBA Mice," Environmental Health Perspectives 99:253-255, 1993 LOR-10186 Gairola, C., "Pulmonary Aryl Hydrocarbon Hydroxylase Activity of Mice, Rats ° 00/00/1987 and Guinea Pigs Following Long Term Exposure to Mainstream and Sidestream Cigarette Smoke," Toxicology 45:177-184, 1987 LOR-10187 Gao, Y-T, et al., "Lung cancer among Chinese women," Int. J. Cancer 00/00/1987 40(5):604-609, 1987 LOR-10188 Gardniner, A., Forey, B., Lee, P., "Avian Exposure and Bronchogenic 00/00/1992 Carcinoma," British Medical Journal 305:989-992, 1992 LOR-10189 Garfinkel, L.I:, at al., "Involuntary smoking and lung cancer: A case-control 00/00/1985 study," J. Natl. Cancer Inst. 75:463-469, 1985 LOR-10190 Garfinkel, L., "Time trends in lung cancer mortality among.nonsmokers and a' 00/00/1981 note on passive smoking," J. NatI. Cancer Inst. 66(6):1061-1066, 1981 LQR-10191 Garland, C:, et al., "Effects of Passive Smoking on Ischemic Heart Disease 00/00/1985 Mortality of Nonsmokers: A Prospective Study," American Journal of Epidemiology 121(5):645-650, 1985 - LOR-10192 Garland, C., et al., "Effects of Passive Smoking in Ischemic Heart Disease 00/00/1985 Mortality of Nonsmokers: A Prospective Study," Erratum, American Journal of, : Epidemiology 122:1112, 1985 LOR-10193 Gebremichael, A., et al:, "Postnatal Development of Cytochrome P4501A1 an 00100/1995 2B1 in Rat Lung and Liver: Effect of Aged and Diluted Sidestream Cigarette Smoke, " Toxicol Appl Pharmacol 135:246-253, 1995 LOR-10194 Geng, G-Y, et al., "On the relationship between smoking and female lung- 00/00/1988 cancer," In: Aoki, M., Hisamichi, S., Tominaga, S., eds. Smoking and Health - 1987. Amsterdam: Excerpta Medica, Elsevier Science Publishers, 483-486, 1988 OR-10195 Gori, G.B., "Policy against science: the case of environmental tobacco 00/00/1995 smoke," RiskAnalysis 15(1):15-22 (1995) Page 7 of 79 98287929
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Exhibit Description: Document Name: Date: LOR-10581 "The Occurrence of Lung Cancer in Man," Morton L. Levin, pp. 531-539 LOR-10582 "Analysis of Epidemiologic Studies: Evaluating the Role of Chance; 00/00/1987 Estimation: Confidence Intervals," Charles H. Hennekens, M.D., et al., Epidemiology in Medicine, pp. 252-255, First Edition, 1987 LOR-10584 Curriculum vitae of William J. Nassetta, M.D. LOR-10585 "Proof of Causation," James J. Schlesselman, Ph.D., et al., Monographs in 00/00/1982 Epidemiology and Biostatistics: Case-Control Studies: Design, Conduct, Analysis, Chapter 1, pp. 24-25, 1982 LOR-10586 "Smoking and Health: Report of the Advisory Committee to the Surgeon 00/00/1964 General of the Public Health Service," U.S. Department of Health, Education, and Welfare, Surgeon General Report, 1964, pp. 20-21 LOR-10621 Deposition transcript of Carolyn Adams taken June 24, 1999, West Virginia- 06/24/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10622 Deposition transcript of Homer Adams taken June 10, 1999, West Virginia- 06/10/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10623 Deposition transcript of Patsy Ellen Alfred taken July 20, 1999, West Virginia- 07/20/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10624 Deposition transcript of Morris YeagerAlderman taken March 4, 1999, West 03/04/1999° Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et aI, v: The American Tobacco Company, et al. (No. 2:97-0978) LOR-10625` Deposition transcript of Dorvin Dean Arnold taken June 7, 1999, West Virginia 0 6/0 711 9 99° Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10626 Deposition transcript of Harold E. Ballengee taken May 21, 1999, West 05/21/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al,. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10627 - Deposition transcript of Larry Gene Barr taken April 7, 1999, West Virginia- 04/07/1999 Ohion Valley Area I.B.E.W. Welfare Fund,, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10628 Deposition transcript of John Bayliss taken March 4, 1999;. West Virginia- 03/04/1999° Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10629 - Deposition transcript of Bakley B. Bell taken July 27, 1999, West Virginia- 07/27/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10630 Deposition transcript of Joseph Bidka taken June 7, 1999, West Virginia-Ohion 06/07/1999 Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10631 Deposition transcript of Larry Albert Borden taken May 28, 1999, West 05/28/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American, Tobacco Company, et al. (No. 2:97-0978) LOR-10632 Deposition transcript of James E. Brown taken June 22, 1999, West Virginia- 06/22/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) - Page 21 of 79 98287943
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Exhibit Description: . Document Name: Date: LOR-1 0936 Boddewyn, Jean; "Cigarette Advertising Bans and Smoking: The Flawed 0 0/0 011 9 94 Policy Connection." The International Journal of Advertising, 1994, Vol. 13, pp. 311-332. LOR-10937 Fazoli's Nutrition Guide 07/00/1996 LOR-10938 Wendy's Nutrition Guide 00/00/1997 LOR-10939 Burger King Nutrition Guide 00/00/1996 LOR-10940 Jack In the Box Nutrition Guide 00/00/1997 LOR-10941 The General Mills American Family Report 1978-1979, Family Health in an 00/00/1978- Era of Stress 0 010 0/1 9 7 9 LOR-10942 Bristol Laboratories Cholesterol Awareness Survey 12/00/1987- 01/00/1988 LOR-10943 Article in New York Times, "Study on Smoking and Cancer is Set" 10/20/1954 LOR-10944 Clarence Cook Little, Tobacco Industry Research Committee, "Report of the 00/00/1956 Scientific Director" LOR-10945 Reprint from 1960.Annual Report of the Scientific Director; Report by the 00/00/1960 Scientific Advisory Board to the Tobacco Industry Research Committee LOR-10946 George V. Allen, Address before 9/1963 Meeting of the National Association o 0 910 0/1 9 6 3 State Departments of Agriculture, "Tobacco and the Public Interest" LOR-10947 Hearings before the Subcommittee on Oversight and Investigations of the 1 0/0 511 978- Committee on Interstate and Foreign Commerce, "Cigarette Smoking and 10/06/1978 Health - Update 1978" LOR-10948 Transcript of ABC Nightline, "ETS and Smoking in the Workplace" 06/25/1990 LOR-1 0949 Reprint of page from Philip Morris Companies, Inc. Annual Report 1990 00/00/1990 LOR-10950Q Hearings before the Subcommittee on Health and the Environment of the 04l00/1994- Committee on Energy and Commerce, House of Representatives, "Regulation 05/00/1994 of Tobacco Products (Part 2) LOR-10951 President Eisenhower Videotape - Press conference - 1957 00/00/1957 LOR-10952 Farmer, John A. and Gotto, Antonio M.; "Atherosclerosis: Pathogenesis and 00/00/1995 Risk Factors," Cardiovascular Medicine LOR-10953 Rothman, Kenneth J.; "Causation and Causal Inference," Cancer 00/00/1982 Epidemiology and Prevention, Ch. 2 LOR-10954 Schlesselman, James J. and Stolley, Paul D.; "Research Strategies,", Case- 00/00/1982 Control Studies: Design, Conduct, Analysis, Chapter 1, pp. 7-26. LOR-10955 Fulton, M.; Thomson, M.; Elton, R.A., Brown, S., Wood, D.A. and Oliver, M.F., 0 0/0 011 9 8 8 "Cigarette Smoking Social Class and Nutrient Intake: Relevance to Coronary , Heart Disease," European Joumal of Clinical Nutrition, 42, 797-803 LOR-10956 Berkson, "Statistics and Tobacco," JAMA, Vol. 172, No. 9 02/27/1960 LOR-10957 Kupka, Breslow,."The Crossing of the Curves: Tuberculosis and Lung 01/00/1957 Cancer," Diseases of the Chest, Vol. XXXI LOR-10958 Feinstein, A.R., Edaile, J.M., Incidence, Prevalence, and Evidence, Scientific 01100/1987 Problems in Epidemiologic Statistics for the Occurrence of Cancer; Am J Med, Vol. 82:113-123 (January 1987) LOR-10959 Walraven, C.V., Wang, B., Ugnat, A, Naylor, C.D., False-positive coding for 00/00/1990 acute myocardial infarction on hospital discharge records: Chart audit results from a tertiary centre; Can J. Cardiol, Vol. 6(9):383-386 (1990) LOR-10960 Lezonni, L.I., Using Administrative Diagnostic Data to Assess the Quality of 00/00/1990 Hospital Care, Pitfalls and Potential of ICD-9-CM; International Journal of Technology Assessment in Health Care, Vol. 6(2):272-281 (1990). Page 36 of 79 98287958
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Exhibit Description: Document Name: Date: LOR-10727 Memorandum from W.E. Hoyt to Directors of the Council regarding a propose 04/14/1978 resolution OR-10728 Report of Research Review Committee, by D.R. Hardy 10/03/1974 LOR-10729 Lorillard Proposal with Respect to Long Range and Specific Planning for CTR Research Activities, by A.W. Spears LOR-10730 Memorandum regarding smoking machine demonstration 1211711970 LOR-10731 Smoking Machine Sub-Committee Proposal, by M. Senkus " 06/24/1968 LOR-10732 Memorandum from H.J. Minnemeyer to F.J. Schultz regarding Nicotine 05104/1976 Augmentation Project (NAP) LOR-1 0733 Article entitled "The Cigarette Industry Changes Its Mind," L.M. Miller, et al., 07/00/1958 Reader's Digest, pp. 35-39, July 1958 LOR-10734 Presentation entitled "The Determination of Saturated Hydrocarbons in 00/00/1962 Cigarette Smoke Condensate," A.W. Spears, et al., Tobacco Chemists Research Conference, 1962 LOR-10735 Presentation entitled "Procedure for Water Soluble Anion Determination 10122/1991 Tobacco and Related Solid Matrices;" F.R. Perini, TCRC or Tobacco Chemists Research Conference, October 22, 1991 LOR-10736 Publication entitled "Phenotypic Instability of Salmonella Strain Yg 1024 00/00/1993 Mutagenicity Assays of Arylamine Promutgnes," R.S. Lake, et al., Mutation Research, No. 301, pp. 157-163, 1993 LOR-10737 Publication-entitled "Studies on the Nicotine Content of Cigarette Smoke," 08/01/1935 C.O. Jenson, et al., Journal of Agricultural Research, Vol. 51, No. 3, pp. 267- 276, August 1, 1935 LOR-10738 Publication entitled "Metal Ion Carcinogenesis: MechanisticAspects;" M. 00/00/1986 Costa, J:D. Heck, Metal Ions in Biological Systems, Vol. 20, pp. 259-278, 1986 OR-10739 Publication entitled "The Contribution of Tobacco Constituents in Phenol Yield 11/18/1962 of Cigarettes," J.H. Bell, et al„ Tobacco Science, Vol. 163, No. 21, pp. 138- - 142, November 18, 1962 LOR-10740 Publication entitled "Gas Liquid Chromatographic Determination of Nicotine 03/00/1979 Contained on Cambridge Filter Pads: Collaborative Study," J.R. Wagner, et : al., J. of Ass. Off. Anal. Chem., Vol. 62, No. 2, pp. 229-236, 1979 LOR-10741 Publication entitled "Determination of Moisture in Total Particulate Matter," F.J. 06/17/1966 Shultz, et al., Tobacco Science, Vol. 10, pp. 75-76 LOR-10742 Publication entitled "Dichlrbenzophenoe as a Nonradioactive Tracer for 02/03/1972 Cigarette Smoke-Gas Chromatographic Analysis of Tracer," C.I. Lewis, et al., Am. Revw of Respiratory Disease, Vol. 106, pp. 480-484, February 3, 1972 LOR-10743 Publication entitled "The Synthesis of Some 2, 4, 5-Trisubstituted Pyrimidines,' 12/00/1960 E. Peters, et al., Journal of Organic Chemistry, Vol. 25, pp. 2137-2142, December 1960 LOR-10744 Publication entitled "The Effect of Some Nitrogenous Blend Components on 06/00/1983 NOINOX and HCN Levels in Mainstream and Sidestream Smoke," V. Norman, et al., Beitrage Zur Tabakforschung Int:, Vol. 12, No. 2, June 1983 LOR-10745 Presentation entitled "The Effects of Tip Dilution on the Filtration Efficiency of.- 10/27/0980 Upstream and Downstream Segments of Cigarette Filters," A.M. Ihrig, et al. LOR-10746 Publication entitled "The Effect of Tip Dilution on the Filtration Efficiency of 07/00/1984 Upstream and Downstream Segments of Cigarette Filters," V. Norman, et al., Beitrage Zur Tabakforschung Int., Vol. 12, No. 4, pp. 178-185, July 1984 98287949 Page 27 of 79
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Exhibit Description: Document Name: Date: LOR-10911 Memorandum from J. P. McGeady to A. B. Hudson re Experimental Cigarettes 01/22/1979 Produced for the Smoking and Health Program of the National Cancer Institut LOR-10912 Letter from F. J. Schultz of Lorillard to Bill Metscher of Enviro Control re 01124/1979 Nicotine Titration Study LOR-10913 Memorandum from F. J. Schultz to Dr. A. W. Spears re Nicotine Titration 05/08/1978 Study LOR-10914 From: Spears, to Whom It May Concern Regarding Certification of Cigarettes. 12/11/1990 - Responses Over 21 LOR-10915 Publication, S.H. Snyder, "The Brain's Own Opicates," C & EN 01/09i1978 LOR-10916 1962 Report of the Royal College of Physicians 00/00/1962 LOR-10918 Publication entitled "Guide to Clinical Prevention Services," U.S. Preventive 04/00/1996 Services Taskforce, Second Edition, April 1996 LOR-10919 Publication entitled "Medical Perspectives on Habituation and Addiction," M.H. 07/14/1962 Seevers, Journal of the American Medical Association, Vol. 181, No. 2, pp. 92 98, July 14, 1962 LOR-10920 Publication entitled "Breaking the Cigarette Habit," S. Ford and F.`Ederer, 10/11/1965 Journal of the American Medical Association, Vol. 194, No. 2, pp. 139-142, . October 11, 1965 LOR-10921 Statement by W.H. Stewart during the Cigarette Labeling and Advertising 00/00/1969 Hearings Before the Committee on Interstate and Foreign Commerce, House of Representatives LOR-10922 Report "Smoking and Health: Report of the Advisory Committee to the ,. Surgeon General of the Public Health Service," U.S. Dept. of Health, Education and Welfare LOR-10923 Weed, DL, "Causal Criteria and Popperian Refutation," Causal Inference, K. 00/00/1988 Rothman ed., Epidemiology Resources, Inc. Boston: Little, Brown and Co.,` 1986,10-21 LOR-10924 Thomas, D.; Comprehensive Textbook of Oncology, "Cancer Epidemiology 00/00/1.991 Prevention", Ch. 22, pp. 153-177 LOR-10925 Rose, Geoffrey; Hamilton, P.J.S.; Colwell, L., Shipley, M; "A Randomized ': 00l00/1982 Controlled trial of anti-smoking advice: 10-year results", Journal of Epidemiology and Community Health, 1982, 34, 102-108 LOR-10926 "Multiple Risk Factor Intervention Trial/Risk Factor Changes and Mortality, :. 0 9 /2411 9 8 2 Results," JAMA, Vol. 248, No. 12, 1465-77 LOR-10927 Weed, D.L.; "On the Logic of Causal Inference", American Journal of 00/00/1986 Epidemiology, 123 (6): 965-79 LOR-10928 Schlesselman; J., "Case-Control Studies: Design, Conduct, Analysis," = 00/00/1982 Monographs in Epidemiology and Biostatistics LOR-10929 Rothman, K., ""Casual Inference in Epidemiology," Modern Epidemiology; 16- 21 LOR-10930 Zajicek, G., Editorial, "Epidemiology Spreads Disinformation," The Cancer . 09/00/1992- Journal, Vol. 5, No. 5 (Sept. - Oct. 1992) 10/00/1992 LOR-10931 Physical Activity and Health, A Report of the Surgeon General, 144-150 00/00/1996 LOR-10932 Nutritional Guidelines of McDonalds 02/00/1997 LOR-1 0933 Nutritional Guidelines of Taco Bell 11/15/1996 LOR-10934 Nutritional Guidelines of Kentucky Fried Chicken 04/00/1993 LOR-1 0935 Jean J. Boddewyn, "Effects of Tobacco Sales Promotion on Initiation of Smoking," Scandinavian Journal of Social Medicine, Vol. 11, number 3, pg. 235, 236. ----^ Page 35 of 79 98287957 ,
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Exhibit Name: Description: Document Date: LOR-10858 Letter from O.W. Adams to H.B. Parmele regarding minutes of a Steering Committee Meeting No. 7, Analysis of cigarette smoke tar 09/28/1958 ILOR-1 085 Letter from O.W. Adams to H. B. Parmele regarding tar analyses 02/13/1959 LOR-10860 Letter from O.W. Adams to H.B. Parmele regarding tar analyses 11/25/1959 LOR-1 0861 Letter from O.W. Adams to H.B. Parmele regarding minutes of Steering Committee held on June 9, 1960, Research status 06/23/1960 LOR-10862 Letter from O.W. Adams to H.B. Parmele regarding research project 01/0311961 LOR-1 0863 Letter from A.W. Spears to J:E. Bennett regarding agreement with Dr. Wynder to conduct experiments 10/02/1967 LOR-10864 Letter from H.B. Parmele to C.O. Jenson regarding Dr. Wynder's request for cigarettes 12/20/1956 LOR-10865 Letter from E.L. Wynder to A.W. Spears regarding request for comments on phenol draft report 03/14/1962 LOR-10866 Presentation entitled "Studies of the Gaseous and Particulate Phase of Tobacco Smoke," E.L. Wynder and D. Hoffman, 53rd Annual Meeting of the American Ass. for Cancer Research, April 1962 04/13/1962 LOR-10867 Letter from D. Davies to A.W. Spears regarding American,Health Foundation "Towards a Less Harmful Cigarette" 07/14/.1969 LOR-1 0868 Letter from F.J. Schultz-to E.L. Wynder regarding difference between mouse skin painting and conventional cigarettes 09/05/1968 LOR-10869 Memorandum from D. Hoffman to E.L. Wynder regarding meeting with Dr. Spears discussing latest studies and results 04/13/1965 LOR-1 0870 Letter from A.W. Spears to J.E. Bennett regarding funding of Homburger & Wynder' 11/22/1965 LOR-10871 Letter from A.W. Spears to J.E. Bennett regarding animal studies conducted a Bio-Research Consultants and Sloan-Kettering - 05/25/1966 - LOR-10872 Speech by H.B. Parmele regarding cancer research - 08/04/1965 LOR-1 0873 Letter from W. Stark to M. Gastman regarding candy cigarettes 07/09/1971 LOR-10874 Letter from R. Goldbrenner to J.W. Powell regarding refusal of request to use - Old Gold advertisement - - 08/20/1974 - - LOR-10875 Memorandum from J.R. Cherry regarding Code of Cigarette Sampling 05/06/1981 LOR-10876 Youth Guidelines - 09/00/1990 LOR-10877 Industry Youth Initiatives 07/00/1990 LOR-10878 Letterfrom S. Chilcote to L. Sullivan regarding discouraging youth smoking 08/28/1992 LOR-10879 Lorillard Marketing Code - 0B/00/1991 LOR-10880 Memorandum from Bresnahan to Brand Management regarding adherence to youth advertising provisions of former Advertising Code 09/01/1972 - LOR-10881 _ Handwritten memorandum from A.J. Stevens to J.R. Ave regarding advertising in college newspapers 07/02/1975 LOR-10882. Letter from R.W. Riddler to Topps Chewing Gum, Inc. regarding BENT Decal 11/29/1973 LOR-10883 Letter from J.R. Ave to H.A: Nelson regarding refusal of Twentieth Century Fox product promotion " 11/12/1984 LOR-10884. Sample 10 Procedures, H. Jessup 02/00/1987 LOR-10885 Memorandum from J.G. Flinn to All Department Members regarding 21 years lower research limit 01/17/1974 - LOR-10886 Report "Confidential Newport 1982 Brand Plan Executive Summary," R.D. Hammer, et al. 01/00/1982 98287955 ; Page 33 of 79
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Exhibit Description: Document Name: Date: LOR-10692 Publication entitled "Nicotine Metabolism in Stumptailed macaques; Macaca 0010011991 arctoides," M. Seaton, et al., Drug Metabolism and Disposition, Vol. 19, No. 5, pp, 946-954, 1991 LOR-10693 Publication entitled "Amount of Nicotine and Carbon Monoxide Inhales by 11/26/1983 Smokers of Low-Tar; Low-Nicotine Cigarettes," R.V. Ebert, et al., JAMA, Vol. 250, No. 20, pp. 2840-2842, November 26, 1983 LOR-10694 Publication entitled "Estimates of Maximum or Average Cigarette Tar; 00/00/1986 Nicotine; and Carbon Monoxide Yields can be Obtained from Yields under Standard Conditions," W.S. Rickert; Prev. Med., Vol. 15, pp. 82-91, 1986 LOR-1 0695 Publication entitled "A Technique for Radio-Labeling Tar Particulate Material in 00/00/1988 Mainstream Cigarette Smoke," J.N. Pritchard, et al., Aerosol Sci., Vol. 19, No. 6, 1988 LOR-10696 Publication entitled "Evidence for Urinary Excretion of Glucuronide Conjugates 0 0/0 011 9 92 of Nicotine; Cotinine and Trans-3'-Hydroxycotinine in Smokers," G.D. Byrd, et al., Drug Metabolism and Disposition, Vol. 20, No. 2, 1992 LOR-10697 Publication entitled "Chemical Studies on Tobacco Smoke. 63. On the Fate. 00/00/1979 of Nicotine during Pyrolysis and in a Burning Cigarette," I. Schmeltz, etal.; J: .. Agric. Food Chem., Vol. 27, No. 3, 1979 LOR-10698 Publication entitled "Patterns of Cigarette Consumption and Cotinine Levels 00/00/1994 among African American Women Smokers," K.L. Ahijevych, et al., Am. J. Respir. Crit. Care; Vol. 150, pp. 1229-1233, 1994 LOR-10699 Publication entitled "Metabolism of Nicotine by Hepatocytes," Biochemical 00/00/1990 Pharmacology, Vol. 40, No. 5, pp. 1747-1756, 1990 LOR-10700 Publication entitled "Plasma nicotine and cotinine concentrations in liabitual 08/00/1981 smokeless tobacco users," Ellen R. Gritz, et al., Clin. Pharmacol. Ther., Vol., 30, No. 2, pp. 201-209; August 1981 LOR-10701 Publication entitled "Smoking Behavior in Low-Yield Cigarette Smokers and 00/00/1991 Switchers'in the Natural Environment," Sakari Kolonen, et al., Pharmacology.° BiocYiemistry & Behavior, Vol. 40, pp. 177-180, 1991 LOR-10702 Publication entitled "Estimating the Hazards of Less Hazardous Cigarettes," . 00/00/1981 W.S:'Rickert, et al., J. of Toxic. and Environ. Health., Vol. 7, pp. 391-403, 1981 LOR-1 0703 Publication entitled "Methods & Designs: Noninvasive measurement of - 00/00/1987 smokers' tar and nicotine intake," T.C. Wu, et al., Behavior Research Methods Instruments & Computers, Vol. 19, No. 3, pp. 295-299, 1987 LOR-10704 Publication entitled "Circadian blood nicotine concentrations during cigarette 12/00/1982 smoking," N.L. Benowitz, , et al., Clin. Pharmacol: Ther., Vol. 32, No. 6, pp. 758 764 LOR-10705 Publication entitled "Influence of Smoking Fewer Cigarettes on Exposure to 11/20/1986 Tar, Nicotine, and Carbon Monoxide," N.L. Benowitz, et al., The New England Journal of Medicine, Vol. 315, No. 21, pp. 1310-1313, Nov. 20, 1986 LOR-10706 Publication entitled "Pharmacokinetics, metabolism, and pharmacodynamics 00/00/1990 of nicotine," N.L. Benowitz, et al., Nicotine Psychopharmacology: Molecular, Cellular, and Behavioural Aspects, pp. 112-157, 1990 LOR-10707 Publication entitled "Accelerated Paper: Self-regulation of smoking intensity. 00/00/1995 Smoke yields of the low-nicotine, low-'tar cigarettes," M.V. Djordjevic, et al., Carcinogenesis, Vol. 16, No. 9, pp. 2015-2021, 1995 LOR-10708 Publication entitled "Age as a Factor in the Metabolism of Nicotine," A.E. Klein, 00/00/1978 et al., European Journal of Drug Metabolism and Pharmacokinetics, No. 1, pp. 51-58, 1978 98287947 -_- Page 25 of 79
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Exhibit Description: Document Name: Date: LOR-1 1030 Third draft of research project by the American Health Foundation: "Toward a less Harmful Cigarette"; American Health Foundation ILOR-1 103 Wynder, E, Epidemiological issues in weak associations, Int J Epidem, (Supp. 00/00/1990 1) 19(3):S5-S7, 1990 LOR-1 1032 Feinleib, M, Biases and weak associations, J Prev Med, 16:150-64, 1987 00I00/1987 LOR-11033 Angell, M, Interpretation of Epidemiological Studies, N Engl J Med,- 09/20/1990 323(12):823-25, 1990 LOR-1 1035 "The Association of Economic Status With the Occurrence of Lung Cancer," 11/00/1975 Cancer, Brown, Selvin, et al. LOR-1 1036 "Occupational Pulmonary Disease," Occupational Medicine, Rosenstock, 04/00/1987- Linda, M.D., M.P.H. 06/00/1987 LOR-11037 "The Health Risk of Radon," Environmental Health, Conrath and Kolb 10/00/1995 LOR-1 1038 "Home Buyer's and Seller's Guide to Radon," Air and Radiation, 0 3/0 011 9 93 Environmental Protection Agency LOR-11039 "How to Reduce Radon Levels in' Your Home...", Consumer's Guide to Radon 08/00/1992 Reduction, EPA LOR-1 1041 Royal College of Physicians of London, "Smoking and Cancer of the Lung." 00/0011967 In: Smoking and Health.° Summary and Report of the Royal College of Physicians of London on Smoking in relation to Cancer of the Lung and Other Diseases. New York, Pitman Publishing Corporation, 1962 LOR-11042 Burch, P.R.J., "Smoking and Lung Cancer: Tests of a Causal Hypothesis." J 0 0/0 011 9 8 0 Chronic Dis 33, 221-238 (1980) LOR-11043 "Differences in Dietary Intake Associated with Smoking Status," European 00/00/1990 Journal of Clinical Nutrition, Hebert and kabat LOR-1 1044 "Dietary Factors and Risk of Lung Cancer: Results From A Case-Control 0 0/0 011 9 9 0 Study, Toronto, 1981-1985," Int. J. Cancer, Jain, M., et aL LOR-1 1045 "Lung Cancer in Hodgkin's Disease: Association With Previous - 02/00i1985 Radiotherapy," Journal of Clinical Oncology, List, Alan F., et al. - LOR-1 1046 "Cigarette Smoking and Lung Cancer Cell Types," Cancer, Morabia and 11/0111991 Wynder LOR-1 1047 "Increased Familial Risk for Lung Cancer," JNCL, Ool, Elston, Chen, et al. 02/02/1986- LOR-11048 Bell, Ireland, Spears, Identification of Aromatic Ketones in Cigarette Smoke 02/00/1969 Condensate, Analytical Chemistry, Vol. 41, page 310. - LOR-11049 "Personal and Family History of Lung Disease as Risk Factors for 1 211 5/1 9 8 8 Adenocarcinoma of the Lung," Cancer Research, Wu, Duncan, Pike, and - Henderson; 7279 - 7284 LOR-1 1050 "Adenocarcinoma of Unknown Anatomic Origin: Evaluation and Therapy," 00/00/1986 Poorly Differentiated Neoplasms and Tumors of Unknown Origin, Sherman and Garnick; 121-150 LOR-1 1051 "Relationships Between Smoking and Other Unhealthy Habits: United States, 1985," NCHS Advancedata, Schoenborn and Benson LOR-11052 Kabat GC, Wynder El., "Lung Cancer In Nonsmokers." Cancer 53:1214-1221, 00L0011984 1984. LOR-11053 Feinstein, A. R. and Wells, C.K., "Cigarette Smoking and Lung Cancer: the 00/00/1974 Problem of'Detection Bias' in Epidemiologic Rates of Disease," Transactions of the Association of American Physicians, 87, 180-85 (1974) LOR-1 1054 Eysenck, H. J., "The Effects of Giving Up Smoking." In: The Causes and 00/00/1980 Effects of Smoking. London, Billing and Sons, 339-357 (1980) 98287962 Page 40 of 79
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Exhibit Description: Document Name: Date: LOR-10805 Letter to Subcommittee on Health and the Environment regarding information 10/27/1994 requests (from A.J. Stevens to H.A. Waxman) OR-10806 Letter from Subcommittee on Health and the Environment regarding bringing 12/20/1994 investigation to a close (from H.A. Waxman to T.J. Bliley) LOR-10807 Memorandum from J.D. Heck to V. Norman regarding "Day One" program 03/10/1994 LOR-10808 Letter from C.O. Jensen to H.B. Parmele regarding catalyst research 01/09/1961 LOR-10809 Lorillard Patent 3,410,277, "Tobacco Having An Oxadiazole Additive" 11/12/1968 LOR-10810 Lorillard Patent #4,091,822, "Article for the Selective Removal of Hydrogen 05/30/1978 Cyanide From Tobacco Smoke" LOR-10811 Lorillard Patent 903,067, "Smoking Tobacco Product" 08/09/1962 LOR-10812 Lorillard Patent #932,988, "Improvements.in or relating to Tobacco Products" 07/31/1963 LOR-10813 "Report to Surgeon General's Advisory Committee on Smoking and Health, 05/00/1963 Materials on Cigarette Filtration" LOR-10814 Publication entitled "Quantitative Determination of Phenol in Cigarette Snioke,' 03/00/1963 A.W. Spears, Analytical Chemistry, Vol. 35, pp. 320-322, March 1963 LOR-10815. Publication entitled "Selective Filtration on Volatile Phenolic Compounds from 04/26/1963 Cigarette Smoke," A.W. Spears, Tobacco Science, Vol. 7, pages 76-80, April 26, 1963 LOR-10816 Report entitled "Reduction of phenol as a positive effect on cilia" LOR-10817 Lorillard Patent 3,217,719 "Cigarette Filters Containing Selective Adaorbents" 11/16/1965 LOR-10818. Lorillard Patent 3,246,655 "Selective Cigarette Filter" 04/19/1966 LOR-10819 Booklet entitled "Selective Filtration of Phenol By Kent's Improved Micronite 00/00/1962 Filter" LOR-10820 List of magazines where Lorillard intends to publish the booklet "Selective 0 010 0/1 9 62 Filtration of Phenol by. Kent's-Improved Micronite Filter" OR-10821 1962 P. Lorillard Company Annual Report 00/00/1962 LOR-10822 Letter from E.W. Monnick forwarding the booklet "Selective Filtration'of Phenol 10/21/1962 by Kent's Improved Micronite Filter" LOR-10823. - Summary of Lorillard research, "Report No. II," A.W. Spears 0811411961 - LOR-10824 Report regarding transfer of PMO to filters and smoking study of PMO treated 02/22/1972 filter cigarettes,.by R:B. Patterson LOR-10825 Publication entitled "Material Balance Studies on Cigarettes Containing 3- 12/00/1974 Phenyl-5-Methyl-1;2,4-Oxadizole," R.S. Marmor, et al., Beitrage Zur Tabak, Vol. 8, No. 4, December 1974 LOR-10826 Publication entitled "Metabolites of 3-Phenyl-5-Methyl-1,2,4-Oxadiazole (PMO) 07/00/1976- in Rats, Dogs and Mice," P.D. Schickedantz, et al., Agri. Food Chem., Vol. 24, 08/00/1976 " No. 4, pp. 876, July/August 1976 LOR-10827 . Report regarding "Protective Action of PMO Against Cigarette Smoke Induced 08/18/1977 Inhibition of Mucociliary Particle Transport in the Chicken Trachea," J.D. Heck, . etal. LOR-10828 Memorandum from P.D. Schickedantz to R.S. Marmor regarding.filter 12/09/1976 cigarettes for Dalhamn clinical study LOR-10829 Report regarding "A Search for Filter Cigarette Designs With Efficient PMO 09/10/1976 Delivery," R.S. Marmor LOR-10830 Letter from H.J. Minnemeyer to T. Dalhamn regarding experimental PMO O 12/10/1976 cigarettes LOR-10831 TWG Minutes of the Eleventh Meeting held April 20 and 21, 1972 04/21/1972 OR-10832 TWG Minutes of the Twelfth Meeting held November 13-14, 1972 11/14/1972 Page 31 of 79 98287953
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Exhibit Description: Document Name: Date: LOR-10633 Deposition transcript of Rex E. Cain taken July 12, 1999, West Virginia-Ohion 07/12/1999 Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10634 Deposition transcript of John R. Clarke taken February 9, 1999, Vol. I, West 02/0911999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10635 Deposition transcript of Donna Lynn Cline taken July 27, 1999, West Virginia- 07/27/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et`al. (No. 2:97-0978) LOR-10636 Deposition transcript of Carletta R. Curley taken May 27, 1999, West Virginia- 05/27/1999 Ohion Valley Area I.B.E.W: Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10637 Deposition transcript of David Vernon Dotson taken June 16, 1999, West 06/16/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10638 Deposition transcript of Glenn Orin Emrick taken June 15,-1999, West Virginia 06/15/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-1 0639 Deposition transcript of Dana Fox taken June 10, 1999, West Virginia-Ohion 06/10/1999 Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10640 Deposition transcript of Mary Jane Gorrell taken July 2, 1999; West Virginia- 07/02/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10641 Deposition transcript of George Gregory Hamm Gresham taken April 19, 1999 04/1911999 West Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v: The America Tobacco Company, et al. (No. 2:97-0978) LOR-10642 Depositioit transcript of Shiela Ice taken May 28, 1999, West Virginia-Ohion : 0512811999 Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. {No: 2:97-0978) LOR-10643 Deposition transcript of William Russell Isaacs, Sr., taken July 27, 1999,West 07/27/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco.Company, et al. (No. 2:97-0978) LOR-10644 Deposition transcript of Michael. Kanick taken June 24, 1999, West Virginia- 06/24/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco. Company, et al. (No. 2:97-0978) LOR-10645 Deposition transcript of Dorothy Kinder taken May 28, 1999, West Virginia- 05/28/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10646 Deposition transcript of Kelly Ann Knuth taken May 28, 1999, West Virginia- 05/28/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10647 Deposition transcript of Danny Louis Leslie, Sr., taken June 15, 1999, West 06/15/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) , LOR-10648 Deposition transcript of Andrew J. Long taken July 13, 1999, West Virginia- 07/13/1999 Ohion Valley Area I:B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) _ Page 22 of 79 98287944
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Exhibit Description: Document Name: Date: LOR-10765 Presentation entitled "Isolation and Identification of Oxygenated Aromatic 00/00/1969 Hydrocarbons From Cigarette Smoke Condensate," J.H. Bell, et al., TCRC Program, 1969 LOR-10766 Publication entitled "Identification of Aromatic Ketones in Cigarette Smoke 02/00/1969 . Condensate," J.H. Bell, et al., Analytical Chemistry, Vol. 41, pp. 310-313, February 1969 LOR-10767 Presentation entitled "The Determination of Saturated Hydrocarbons in . 00/00/1962 Cigarette Smoke Condensate;" A.W. Spears, et al., TCRC Program, 1962 LOR-10768 Presentation entitled "Identification of Alkylated Phenanthrenes in Cigarette 00/00/1969 Smoke Condensate," J.H. Bell, et al., TCRC Program, 1969 LOR-10769 Presentation entitled "A Combined Approach to the Quantitative Analysis of 00/00/1964 the Volatile Components of Cigarette Smoke," A.W. Spears, et al., Tobacco Chemist Research Conference, 1964 LOR-10770 Publication entitled "Quantitative Determination of Alkanes in Cigarette 04/00/1963 Smoke," A.W. Spears, et al., The Journal of Gas Chromatography; April 1963 LOR_-10771 Publication entitled "Chemical and Physical Criteria for Tobacco Leaf and - 00/00/1981 Modern Day Cigarettes," A.W. Spears, et al., Recent Advances in Tobacco - Science, Vol. 75, pp. 19-39, 1981 LOR-1 0772 Publication entitled "Affect of Manufacturing Variables on Cigarette Smoke 00/00/1974 Composition," A.1N. Spears, Coresta Special Information Bulletin, pp. 65-78, 1974 . LOR-10773 Report regarding "The Addition of Nicotine to Tobaccos; A Progress Report," 0 1 /3111 9 7 7 J.P. Morgan, et al. LOR-10774 Publication entitled "The Determination of 'Free Nicotine' in Tobacco: The 10/00/1929 Apparent Dissociation Constants of Nicotine," H.B. Vickery, et al., The Journal of Biological Chemistry, Vol. LXXXIV, No. 1, pp. 233-241, October 1929 LOR-10775 Publication entitled "The Chemistry and Technology of Tobacco,"'A.A: Shmuk, 00/00/1953 Pishchepromizdat, Moscow, Vol. 3, 1953 LOR-10776 Memorandum from F.J. Schultz to H.J. Minnemeyer regarding "Continuation o 02/09/1977 Nicotine Augmentation Project (CONAP)" LOR-10777 Publication entitled "Low Tar Medium - Nicotine Cigarettes: A New Approach 12/01/4973 to Safer Smoking," M.A.H. Russell, British Medical Journal, pp. 512-516, December 1, 1973 LOR-10778 Article entitled "Less Tar, Less Nicotine: Is,That Good?'." Consumer Reports, 05/00/1976 May 1976 LOR-10779 Meeting Minutes of the National Cancer Institute - Smoking & Health Program, 11/05/1976 Workshop to Design Series V Experimental Cigarettes, November 5, 1976 LOR-10780 Publication entitled "Low Risk Cigarettes: A Prescription,"--G. Gori, Science, ' 12/00L1976 Vol. 194, pp. 1243-1246, December 1976 LOR-10781 Publication entitled "Comparison of Effect on Tobacco Consumption and 1 210 0 /1 97 3 Carbon Monoxide Absorption of Changing to High and Low Nicotine Cigarettes," M:A.H. Russell, et al., British Medical Journal, pp. 512-516, December 1973 LOR-10782 Publication entitled "Pharmacological Aspects of Cigarette.Smoking and 11/17/1988 Nicotine Addiction," N. Benowitz, New England Journal of Medicine, pp. 1318- 1330, November 17, 1988 LOR-10783 Publication entitled "Reduction of Tar, Nicotine and Carbon Monoxide Intake in 00/00/1986 Low Tar Smokers," M.A.H. Russell, et al., Journal of Epid. and Community Health, Vol. 40, pp. 80-85, 1986 --_--- Page 29 of 79 98287951 --
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Exhibit Description: Document Name: Date: LOR-10982 "Comparison of multivariate predictive power of major risk factors for coronary 02/00/1996 heart diseases in different countries: results from eight nations of the Seven Countries Study, 25-year follow-up," Journal of Cardiovascular Risk, Vol. 3, No. 1, February 1996 LOR-1 0983 "Cigarette Smoking in Relation to the "Risk of Myocardial Infarction in Young 00/00/1980 Women. Modifying Influence of Age and Predisposing Factors," International Journal of Epidemiology, 1980 LOR-10984 "Relative and Absolute Excess Risks of Coronary Heart Disease Among 00/00/1987 Women Who Smoke Cigarettes," New England Journal of Medicine, 1987 LOR-10985 "Lower Socioeconomic Status and Increased Mortality: Early Childhood Roots 06/03/1998 and the Potential for Successful Intervention," JAMA, 279(21):1703-1708, June 3, 1998 LOR-10991 Murabito, J., D'Agostino, R., Silbershatz, H., Wilson, P., Intermittent Claudication, A Risk Profile from the Framingham Heart Study LOR-10992 Tate, R., Manfreda, J., Cuddy, R., "The Effect of Age on Risk Factors for 10/0.0/1998 Ischemic Heart Disease: The Manitoba Follow-up Study, 1948-1993,"Ann Epidemiol, Vol. 8, No. 7; 415-421 LOR-10993 Rothman, K.J., Modern Epidemiology, Little, Brown & Co.; 1986 00/00/1986 LOR-10994 28. Rothman, K.J., Causal Inference, Epidemiology Resources, Inc. 1988 00/00/1988 LOR-10995 "Science on Trial," by Angell, Marcia L_OR-10996 Kato, I, et al., "Characteristics of Past Smokers" International Journal of Epidemiology, Vol. 18, No. 2, p. 345-54 LOR-1 0997 Kaprio, J., et al., "A Prospective Study of Psychological and Socioeconomic Characteristics, Healthy Behavior and Morbidity in Cigarette Smokers Prior to Quitting Compared to Persistent Smokers and Non-Smokers" J. Clinical Epidemiology, Vol. 41, No. 2, p. LOR-10999 Bolton-Smith, C., et al., "Nutrient intake by duration ex-smoking in the Scottish 00/00/1993 Heart Healthy Study" British J. of Nutrition, (1993), 69, 315-32 LOR-11001 11. Whichelow, M.J., et al. "Comparison of Some Dietary Habits of Smokers 00/00/1988, and Non-Smokers" British Journal of Addiction, 83, 295-304 LOR-11002 Johnson, N.A., et al. "Leisure-time physical activity and other_ health behaviors: 00/00/1995 are they related?" Australian J. Public Health, Vol. 19, No. 1, p. 69-75 (1995) LOR-11003 Eaton, C.B., et al. "Self-Reported Physical Activity In a Rural County: ounty: A New 00/00/1994 York County Health Census" Am. J. Pub. Health, Vol. 84, No. 1, p. 29-32 (1994) LOR-11004 Nebeling, L.C., et al. "The Impact of Lifestyle Characteristics on Carotenoid 02/00/1997 Intake in the United States: The 1987 National Health Interview Survey" Am. J. Pub. Health, Vol. 87, No. 2, p. 268-271, (February 1997) LOR-1 1005 Tang, J., et al. "Health profiles of current and former smokers and lifelong 05100/1997- abstainers" J. Royal College of Physicians of London, Vol. 31, No. 3, p. 304- 06/00/1997 09 (May/June 1997) LOR-1 1006 Serdula, M.K., et al. "The Association Between Fruit and Vegetable Intake 03/00/1996 and Chronic Disease Risk Factors" Epidemiology, Vol. 7, No. o. 2, p. 161-65 (March 1996). LOR-1 1007 Tillotson, J.L., et al. "Chapter 5. Food group and nutrient;intakes at baseline 00/00/1997 in the Multiple Risk Factor Intervention Trial" Am. J. Clin. Nutr., Vol. 65, No. 1(S), p. 228S-57S (1997) OR-11008 18. Vecchia, C.L., et al. "Differences in Dietary Intake With Smoking, Alcohol, 00/00/1992 and Education" Nutrition and Cancer, Vol. 17, No. 3, p. 297-304 (1992) 98287960 Page 38 of 79
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Exhibit Description: Document Name: Date: LOR-11087 1.981 Surgeon General Report: The Health Consequences of Smoking - The 00/00/1981 Changing Cigarette" LOR-11088 The Health Consequences of Smoking; Cardiovascular Disease: A Report of 00/00/1983 the Surgeon General (1983 SG Report) LOR-11089 U.S.D.H.E.W. The Health Consequences of Smoking - Chronic Obstructive 00/00/1984 Lung Disease. Report of the Surgeon General LOR-11090 "The Health Consequences of Smoking: Cancer and Chronic Lung Disease in 00/00/1985 the Workplace, A Report of the Surgeon General," U.S. Department of Health and Human Services LOR-11091 A Report of the Advisory Committee to the Surgeon General: The Health 04/00/1986 Consequences of Using Smokeless Tobacco LOR-1_1092 1989 Surgeon General's Report, "Reducing the Health Consequences of 00/00/1989 Smoking" LOR-1 1094 "Smoking and Health in the Americas, A 1992 Report of the Surgeon General, 00/00/1992 in collaboration with the Pan American Health Organization," U.S. Department of Health and Human Services LOR-11095 "Preventing Tobacco Use Among Young People, A Report of the Surgeon 00/00/1994 General," U.S. Department of Health and Human Services LOR-11096 "Physical Activity and Health, A Report of the Surgeon General," U.S. 00/00/1996 Department of Health and Human Services LOR-11097 "Tobacco Use Among U.S. Racial/Ethnic Minority Groups: African Americans, 00/00/1998 American Indians and Alaska Natives; Asian Americans and Pacific Islanders, Hispanics, A Report of the Surgeon General," U.S. Department of Health and Human Services LOR-1109_8 National Cancer Institute Smoking and Health Program;.Report No. 5: Toward 09/00/1980 less hazardous cigarettes: Summary: Four Skin Painting Bioassays Using Condensate from Experimental Cigarettes LOR-11099 National Cancer Institute Smoking and Health Program; Report No.-1:. "Towar- Less Hazardous Cigarettes: The First Set of Experimental Cigarettes," G. Gor LOR-11100 National Cancer Institute Smoking and Health Program; Report No.' 2: "Toward Less Hazardous Cigarettes: The Second Set of Experimental Cigarettes," G. Gori LOR-11101 National Cancer Institute Smoking. and Health Program; Report No:-3: "Towar Less Hazardous Cigarettes: The Third Set of Experimental Cigarettes," G. Gori LOR-1 1102 National Cancer Institute Smoking and Health Program; Report No:-4: "Towar d 03/00/1980 Less Hazardous Cigarettes: The Fourth Set of Experimental Cigarettes," G. : . . . _ God LOR-11103 Dr. Clarence Little, Scientific Director, TIRC and Chairman, Scientific Advisory 09/22/1954 Board, in "Study on Smoking and Cancer is Set," New York Times (9/22/54) LOR-1 1104 Dr. Clarence Little, CBS Reports: The Teenage Smoker, September 19, 1962 09/1911962 and Ed Murrow's "See it now" Program Part II - CD LOR-11106 Dr: Robert Hockett, Research Director of CTR, testimony in Cigarette Smoking 10/05/1978 and Health Update Hearings before the Subcommittee on Oversight and Investigations of the Committee on Interstate and Foreign Commerce, House of Representatives, Ninety-Fifth Congress, 2nd Session (10/5/78) LOR-11107 Charles O. Whitley, Tobacco Institute, Congressional Hearings on . 0 2 /0 711 9 94 Environmental Tobacco Smoke (2l7/94) OR-11108 A Dictionary of Epidemiology, 25 (3d ed. 1995) 0 0/0 011 9 9 5 Page 42 of 79 98287964
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Exhibit Description: Document Name: Date: LOR-10394 Charleston Daily Mail, January 5, 1970, p. 13, "Stop Abruptly, But Do It Day- 01/05/1970 By-Day - Physician Tells How He Quit Smoking," by Tom Cummings OR-10395 Charleston Daily Mail, December 5, 1972, p. 1 B, "'Cold Turkey' Withdrawal - 12/05/1972 Quit Smoking Prescription Strict," by Ron Hutchison LOR-10396 Charleston Daily Mail, Apirl 13, 1973, p. 2A, "Puffing With An Ugh! Aversive 04/13/1973 Conditioning Breaks Habit" LOR-10397 Charleston Daily Mail, September 15, 1977, p. 1.B, "Quitting - Cancer Society's 0 9/1 511 9 7 7 Clinics Working For City Puffers," by Ruth Jones LOR-10398 Charleston Daily Mail, December 23, 1977, p. 6A, "Smoking No Addiction" 1 212 3/1 9 7 7 LOR-10399 Charleston Daily Mail, March 5, 1981, p. 5A, "Elkview Smoker Goes'Cold 03/05/1981 Turkey"' by Bill Byrd LOR-10400 Charleston Daily Mail, September 15, 1954, p. 4, "FTC Proposes Standards 09/15/1954 For Cigarette Advertising" LOR-10401 Charleston Daily Mail, July 9; 1969, p. 38, "4-Year TV Phase-Out Of Cigarette 0 710 9/1 9 69 Ads Set" LOR-10402 Charleston Daily Mail, March 4, 1970, p. 45, "Cigarette Commercial Ban 03/04/1970 Approval Assured" LOR-10403 Charleston Daily Mail, April 2, 1970, p. 28, "Cigarette Commercial Ban Signed" 04/02/1970 LOR-10404 Charleston Daily Mail, February 1, 1972, p. 7A, "Order Will Put Warning On All 02/01/1972 Cigarette Ads" LOR-10405 Charleston Daily Mail, December 10, 1952, p. 20, "Tobacco Listed As Cause 12/10/1952 Of Artery Damage" LOR-10406 Charleston Daily Mail, January 30, 1974, p. 8C, "Society Starts Smokers" 01/30/1974 LOR-10407 Charleston Daily Mail, October 3, 1957, p. 8, "Theater Man Loses Anti- 1 0/0 311 9 57 Cigarette Fight" OR-10408 Charleston Daily Mail, November 19, 1980, p. 7A, "Smokeout Gives Puffers A 11/19/1980 Day To Catch Their Breath" LOR-10409 Charleston Daily Mail, November 15, 1979, p. 6D, "Great Smoke-Out Doomed 11/15/1979 -'Nicotine Addicts' Apparently Will Go On Puffing" LOR-10410 Charleston Gazette, July 18, 1950, p. 1, "Scientists Blame Smoking For Lung 07/18/1950 Cancer Growth" LOR-10411 Charleston Gazette, December 12, 1952, p. 1, "Smoking Linked To Cancer 12/12/1952 Toll In 4-Year Study" LOR-10412 Charleston Gazette, October 29, 1953, p. 2, "Texas Doctor Condemns 1 0/2911 9 53 Tobacco as Irritating" LOR-10413 Charleston Gazette, December 21, 1953, p. 24, "Cancer, Cigarette Tie-Up 12/21/1953 Research Sought by Dewey" LOR-10414 Charleston Gazette, March 19, 1954, p. 23, "'Evidence Justifies Suspicion' - 03/19/1954 Cancer Society Cautious But Frowns on Cigarettes" LOR-10415 Charleston Gazette, June 22, 1954, p. 1, "Cigarette a Killer, Scientists Say" 06/22/1954 LOR-10416 Charleston Gazette, June 23, 1954, p. 1, "Doctors Are Reticent - Cigarette 06/23/1954 Scare Seemingly Fails to Faze Smokers Here," by William Keenan LOR-10417 Charleston Gazette, June 23, 1954, p. 9, "Tip to Cigarette Smokers: Don't 06/23/1954 Inhale, Noted Cancer Expert Advises" LOR-10418 Charleston Gazette, June 29, 1954, p. 1, "He's Switched to Pipe - Cigarettes 06/29/1954 Cut Five Years Off Life, Researcher Says" LOR-10419 Charleston Gazette, July 7, 1954, p. 22, "Still Sneaks Cigarettes - Cancer 07/07/1954 Expert Converts Wife to Smoking Pipes" Page 15 of 79 98287937
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Exhibit Description: Document Name: Date: LOR-11109 Federal Judicial Center,.Reference Manual on Scientific Evidence: Epidemiology, at 126 OR-11110 S. Lanes, "Causal inference is not a matter of science." Am. J. Epidemiol. 00/00/1985 (1985) 122:550 LOR-11111 K. Rothman & S. Greenland, Modern Epidemiology (2d ed. 1998), Lippencott- 00/00/1998 Raven, Philadelphia, Pennsylvania LOR-11112 Fletcher, R.H., Fletcher, S.W., Wagner, E.H., Clinical Epidemiology: The 00/00/1996 Essentials; Baltimore: Williams & Wilkins, (3d ed. 1996) 235. LOR-11113 D. Kleinbaum, L: Kupper, H. Morganstern, Epidemiologic Research, Principles 00/00/1982 and Quantitative Methods, Van Nostrand Rheinhold (1982) at 29. LO_R-11114 Weed and Gorelic, The Practice of Causal Inference in Epidemiology, Cancer 00/00/1996 Epidemiology, Biomarkers, and Prevention, Vol: 5, 303-311 (1996) LOR-11115 Schlesselman, J., Case Control Studies, Oxford Univ. Press (1982) at 24-25. 00/00/1982 LOR-1 1116 R. Peto and R. Doll, The Control of Lung Cancer, New Scientist, 104 00/00/1985 (1440):26-30 (1985) LOR-11117 "The Gallup Report: Political, Social and Economic Trends - Percent.of 07100/1981 Americans Who Smoke," Report No. 190; Gallup Smoking Audit LOR-11118 "The Gallup Poll: Public Opinion 1990" 00/00/1990 LOR-11119 "The Gallup Poll: Public Opinion 1972-1977 " Gallup Dr. George H. , , , American Institute of Public Opinion; Volume Two 1976-1977 LOR-11120 "The Gallup Poll: Public Opinion 1935-1971," Gallup, Dr. George H., American Institute of Public Opinion; Volume Two 1949-1958 LOR-11121 Letter from Lisa Ferraro Parmelee, of the Roper Center for Public Opinion 09/26/1997 - Research, certifying true and correct copies of data held in the public opinion location library database and public opinion archive of the Roper Center for Public Opinion Research at the University of Connecticut. LOR-11122 Roper Reports, 81-7 08/00/1981 LOR-11123 Roper Reports, 78-7 09/00/1978 LOR-11124 Roper Reports, 80-4 05/0011980 LOR-11125 Roper print outs 10/00/1958- 11 /00/1990 LOR-11126 Letter from Lisa Ferraro Parmlelee„Ph.D. of the Roper Center, certifying,true 09/30/1997 and correct copies of data held in the public opinion library database and" = public opinion archive of the Roper Center for Public Opinion Research at the University of Connecticut. _ LOR-11127 Roper Reports, 77-3 02/00/1977-- 04/00/1977. LOR-11128 Roper Reports, 79-3 . 02/00/1979- 04/00/1979 LOR-11129 Roper Reports, 79-9 09/00/1979- 11/00/1979 LOR-11130 Roper Reports, 81-3 02/00/1981- 04I0011981 LOR-1 1131 Roper Reports, 87-3 02/00/1987- 05/00/1987 LOR-1 1132 The Gallup Poll: American Institute of Public,Opinion, Subject: Health 07/00/1957 Information, "Do you think cigarette smoking is one of the causes of heart disease?" 98287965 Page 43 of 79
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Exhibit Description: Document Name: Date: LOR-10369 Charleston Daily Mail, May 22, 1979, p. 1, cont'd. 2A, "'Suicide' State Smokes 05/22/1979 237 Mil!ion Packs Yearly," by Steve Mullins OR-10370 Charleston Daily Mail, September 17, 1980, p. 1, cont'd 8A, "State Cancer 09/17/1980 Death Rate Again Tops U.S. Average," by Bill Byrd LOR-10371 Charleston Daily Mail, September 29, 1980, p. 1, con't. 8A, "State Heart 09/29/1980 Disease Death Rate No. 1," by Elizabeth Older LOR-10372 Charleston Daily Mail, October 30, 1981, p. 4A, "Lung Group Will Help 10/30/1981 Smokers Quit" LOR-10373 Charleston Daily Mail, November19, 1981, p. 1, cont'd. 10A, "Area Cigarette : 11/19/1981 Puffers Ponder Meaning Of Smokeout Campaign," by Bill Byrd LOR-10374 Charleston Daily Mail, May 6, 1983, p. 2A, "Clark's Widow Blames Death On 05/06/1983 Cigarettes" LOR-10375 Charleston Daily Mail, May 26, 1983, p. 1 B, "Hard Facts" 05/26/1983, LOR-10376 Charleston Daily Mail, February 29, 1984, p. 8D, "Research Details Heart 02/29/1984 Attack Risks" LOR-10377 Charleston Daily Mail, May 9, 1984, p. 8A, "FTC Favors Rotating Cigarette 05/09/1984 Warnings" LOR-10378 Charleston Daily Mail, August 1, 1984, p. 3C, "Heart Disease Statistics 08/01/1984, Demand Lifestyle Changes" LOR-10379 Charleston Daily Mail, November 14, 1984, p. 14A, "'Breathing Easy' PBS 11/14/1984 Special Targets Teen-Age Smoking," by Marcia Dunn LOR-10380 Charleston Gazette, February 18, 1985, p. 3A, "Smoking deaths said doubled" 02/18/1985 LOR-10381 Charleston Daily Mail, June 13, 1985, p. 10A, "Female smokers' ers' heart attack 06/13/1985. risk" OR-10382 Charleston Daily Mail, November 13, 1985, p. 1C, con't. 2C, "The Great ' 11/13/1985 American Smokeout" ' LOR-10383 Charleston Dai!yMai!, February 28, 1986, p. 7A, "Medical Journal Escalates 0212811986• War Against Smoking, Tobacco Products" LOR-10384 Charleston Daily Mail, August 15, 1986, p. 9B, "For Heart Disease, Study Say 08/15/1986 - Smokers Taking Pill At Risk" LOR-10385 Charleston Daily Mail, January 27, 1964, p. 8, "Hazard! Cigarette Findings 01/27/1964 . _ Accepted" LOR-10386 Charleston Daily Mail, May 26, 1964, p. 5, "Your Heart Has Nine Lives - Foil 05/26/1964 Four Deadly Heart Assassins" LOR-10387 Charleston Daily Mail, May 18, 1964, p. 3, "Your Heart Has Nine Lives - What 05/18/1964 You Can Do About America's No. 1 Killer" LOR-10388 Charleston Daily Mail, November 11, 1954, p. 17, "Report On Cigarettes' Link 11/11/1954 To Heart Attacks Recalled" LOR-10389 Charleston Daily Mail, February 18, 1955, p. 36, "You Can Quit Smoking If 02/18/1955 You Satisfy That'Muscle Hunger" by Dr. George W. Crane LOR-10390 Charleston Daily Mail, June 22, 1955, p. 10, "Million And Half Smokers Swear 06/22/1955 Off In Last 18 Mos." LOR-10391 Charleston Daily Mail, August 9, 1957, p. 17, "Worry Clinic - Bad Smoking 08/09/1957 Habit Can Be Broken," by Dr. George W. Crane LOR-10392 Charleston Daily Mail, October 28, 1963, p. 13, "'Tobaccoholic' Reporter 10/28/1963 Begins 5-Day Cure Plan" LOR-10393 Charleston Daily Mail, September 12, 1967, p. 2, "Hooked On Cigarettes? 0 9/1 211 9 6 7 New Test May Tell You Why" Page 14 of 79 98287936
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Exhibit Description: Document Name: Date: LOR-10104 Mulshine, et al., "Prevention-Oriented Applications of Biomarkers to Follow the 06/00/1994 Process of Lung Carcinogens," Lung Cancer, June 1994 OR-10106 Multiple Risk Factor Intervention Trial Research Group, "Mortality Rates After 00/00/1990 10.5 Years For Participants in the Multiple Risk Factor Intervention Trial," JAMA 263 (13):1795-1801 (1990) LOR-10108 Murabito, J.; et at., "Intermittent Claudication, A Risk Profile from the 00/00/1997 Framingham Heart Study," Circulation, 96:44-49 (1997) LOR-10109 Neaton, J. and Wentworth, D., "Serum Cholesterol, Blood Pressure, Cigarette 00/0011992 Smoking, and Death from Coronary Heart Disease," Arch Intern Med, Vol. 152; 56-64 (1992) LOR-10110 Neaton, J., et al., "Total and Cardiovascular mortality in relation to cigarette 00/00/1984 smoking, serum cholesterol concentration, and diastolic blood pressure among black and white males followed up for five years," Am. Heart J., 108(3): 759-77 (1984) LOR-10111 "Non-Invasive Detection of Atherosclerosis," (editorial) New Eng J Med, 00/00/1998 339(27): 2014 (1998) LOR-10112 Olson, R.E., "Cholesterol and the Heart, Will We Mislead the Public?," Modern 00/00/1983 Medicine 51(2): 15, 18, 22-24. (1983) LOR-10115 Petty, T.L., et al., "Building a National Strategy for the Prevention and 00/00/1997 Management of and Research in Chronic Obstructive Pulmonary Disease," JAMA 277:246 (1997) LOR-10117 Raggi, et al., "Identification of Patients at Increased Risk of First Unheralded 00/0012000 Acute Myocardial Infarction by Electron-Beam Computed Tomography," Circ.101:850 (2000) LOR-10118 "Reducing the Health Consequences of Smoking," Surgeon General's Report 00/00/1989 1989 LOR-10119 Rogot and Murray, "Smoking and Causes of Death Among US Veterans," 00/00/1980 Public Health Reports 96:213 (1980) LOR-10120 Rosenberg, L., et al., "Cigarette Smoking in Relation to the Risk of Myocardial 00/00/1980 Infarction in Young Women. Modifying Influence of Age and Predisposing Factors," International Journal of Epidemiology, 1980 LOR-10121 Ross, R., "The Pathogenesis of Atherosclerosis," In: Heart Disease. A 00/00/1997 Textbook of Cardiovascular Medicine. E. Braunwald (ed.), 5th edition. W.B. Saunders Company, Philadelphia, Chapter 34, pp. 1105-1125, 1997 LOR-10122 Salomaa, et al., "Prognosis of Patients with Lung Cancer Found in a Single 00/00/1998 Chest Radiogram Screening," 114:1514 (1998) LOR-10123 Salonen, J.T., "Analysis of Community-Based Cardiovascular Disease 00/00/1986 Prevention Studies," Int J Epidem 15:176 (1986) LOR-10127 Seltzer, C.C., "Framingham Study Data and 'Established Wisdom' About 00/00/1989 Cigarette Smoking and Coronary Heart Disease," J Clin Epidemiol, 42 (8):743- 750 (1989) LOR-10128 Siorino, A.S., "Electron-Beam Computed Tomography, Coronary Artery 00/00/1998 Calcium, and Evaluation of Patients with Coronary Artery Disease," Ann Int Med 128:839 (1998), LOR-10132 Sortie, P., et al., "Cigarette Smoking and Coronary Heart Disease in Puerto 00/00/1982 Rico," Preventive Medicine 11: 304-316 (1982) 98287926 Page 4 of 79
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Exhibit Description: Document Name: Date: LOR-10344 Charleston Daily Mail, November 18, 1959, p. 7, "Okla. Widow Sues Cigarette 11/18/1959 Firm in Hubby's Death" OR-10345 Charleston Daily Mail, June 21, 1960, p. 17, "TB Association Warns of Cancer 06/21/1960 Smoking Link" LOR-10346 Charleston Daily Mail, April 12, 1962, p. 28, "Smoking Mothers Producing 04/12/1962 Tinier, Less Healthy Babies" LOR-10347 Charleston Daily Mail, September 6, 1962, p. 26, "Smoking Said Major Factor 09/06/1962 in Lung Cancer" LOR-10348 Charleston Daily Mail, November 10, 1962, p. 5, "Cigarette Firm Not Blamed - 11/10/1962 Smoking, Cancer Linked by Jurors" LOR-10349 Charleston Daily Mail, December 27, 1962, p. 15, "How About 'No-Fag' ; 12/27/1962 Resolution? Cigarettes And Cancer Concern W. Va. Official" LOR-10350 Charleston Daily Mail, June 13, 1963, p. 7, "Smoking Branded Top 06/13/1963 Preventable Disease Producer" LOR-10351 Charleston Daily Mail, September 26, 1963, p. 32, "Cancer Study Said To . 09/26/1963 Point To Cigarettes" LOR-10352 Charleston Daily Mail, December 4,.1963, p. 18, "New Study Links Cigarette 12/04/1963 Smoking, Higher Death Rate" LOR-10353 Charleston Daily Mail, January 11, 1964, p. 1, "Report Pins Early Death On 01/11/1964 Smoking - 'Corrective Action' Needed; Cancer One Of Many Hazards" LOR-10354 Charleston Daily Mail, January 11, 1965, p. 1, "Cigarettes One Year Later" . 01/11/1965 LOR-10355 Charleston Daily Mail, July 1, 1965, p. 35, "Compromise Reached.On 07/01/1965 Cigarette Warning" LOR-10356 Charleston Daily Mail, September 2, 1965, p. 10, "Smoking Branded Peril To 09/02/1965 Health In U.S. Pamphlet" OR-10357 Charleston Gazette, November 30, 1966, p. 4, "Death Study Report Ominous 11/30/1966 for Smoker" LOR-10358 Charleston Daily Mail, July 1, 1968, p. 23, "Toughened Warning Labels On . 07/01/1968 Cigarettes To Be Urged" LOR-10359 - Charleston Daily Mail, November 6, 1969, p. 11, "Social Pressures Pusti 4 Ou 11/06/1969 Of 10 Teens To Cigarettes" LOR-10360 Charleston Daily Mail, September 8, 1972, p. 13A, "Women Smoking More; - 09/08/1972 Getting More Oral Cancer" LOR-10361 Charleston Daily Mail, December 4, 1974, p. 7D, "Lung Cancer Feared As 12/04/1974 National Calamity" LOR-10362 Charleston Daily Mail, December 16, 1974, p: 12B, "Congress Under Fire - 12/16/1974 Tobacco Grower Subsidies Raked" LOR-10363 Charleston Daily Mail, March 30, 1977, p. 8B, "In Women Over 40 - Pill, 03/30/1977 Smoking Raise Heart Attack Risk" LOR-10364 Charleston Daily Mail, November 17, 1977, p. 9A, "Americans Hold Big Smoke 11/17/1977 Out," by The Associated Press LOR-1 0365 Charleston Daily Mail, October 20, 1978, p. 3A, "More Women Dying From 10/20I1978 Lung Cancer" LOR-1 0366 Charleston Daily Mail, October 26, 1978, p. 8A, "Tobacco Plays Strange Role 10/26/1978 In Our Lives" LOR-10367 Charleston Daily Mail, November 16, 1978, p. 3A, "Will 'Smokeout' Effects . 11/16/1978 Linger?"' OR-10368 Charleston Daily Mail, December 25, 1978, p. 12D, "if Begging Smoker To 12/25/1978 Quit Doesn't Work, Use These Facts" - Page 13 of 79 98287935
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Exhibit Description: Document Name: - Date: LOR-10709 Publication entitled 'Variations in Amounts of Tobacco Tar Retrieved from 00/00/1963 Selected Models of Smoking Behavior Simulated by Smoking Machine," S. Graham, et al., Cancer Research, Vol. 23, pp. 1025-1030, 1963 LOR-10710 Publication entitled "Smoking Machine Parameters and Cigarette Smoke 0 0/0 011 9 8 8 Yields," K.G. Darrall, The Science of the Total Environment, Vol. 74, pp. 263- 278, 1988 . LOR-10711 Publication entitled, "The effect of smoking on nicotine metabolism in vivo in 00/00/1971 man," A.H. Beckett, et al., J. Pharm. Pharmaa, Vol. 23, Suppl., pp. 62S-67S, 1971 LOR-10712 Publication entitled "Long-term effects of switching to cigarettes with lower tar 00/00/1989 and nicotine yields," A.R. Guyatt, et al., Psychopharmacology, Vol. 99, pp. 80- 86,1989 LOR-10713 Publication entitled "Pharmacoepidemiology and Drug Utilization: liow the 09/00/1992 steady-state cotinine concentration in cigarette smokers is directly related to nicotine intake," M. Ross, et al., Clinical Pharmacology Therapy, Vol. 52, No. - 3, pp. 324-329, September 1992 LOR-10714 Publication entitled "Smoke Yield of Cigarettes and Puffing Behavior in Men 0010011982 and Women," K. Battig, et al., Psychopharmacology, No. 76, pp. 139-148 LOR-10715 Publication entitled "Relation of nicotine yield of cigarettes to blood nicotine 04/00/1980 concentrations in smokers," M.A.H. Russell, et al., British Medical Journal, No. 5, pp. 972-976, April 1980 LOR-10716 Publication entitled "Titration of nicotine intake with full length and,half-length 11/00/1976 cigarettes," E.R. Gritz, et al., Clinical Pharmacology and Therapeutics, Vol. 20, No. 5, pp. 552-556, November 1976 LOR-10717 Publication entitled "Stable isotope studies of nicotine kinetics and 03/00/1991 bioavailability," N.L. Benowitz, et al., Clin. Pharmacol. Ther., Vol. 49, No. 3, pp 270-277 LOR-10718 Publication entitled "Switching to low tar cigarettes: are the tar• league tables 00/00/1984 relevant?" R.G. Rawbone, Thorax, Vol. 39, pp. 657-662, 1984 LOR-10719 Publication entitled "Nicotine Exposure Among Nondependent.Smokers," S. 04/00/1990 Shiffman, et al., Arch. Gen. Psychiatry, Vol. 47, pp. 333-336, April 1990 LOR-10720 Publication entitled "Tobacco chippers'--individual differences in tobacco 00I00/1989 dependence," S. Shiffman, Psychopharmacology, Vol. 97, pp. 539-547, 1989 LOR-10721 Publication entitled "Consumption of Cigarettes of Reduced Tar and Nicotine 00/00/1980 Delivery," M.A. Stepney, Br. J. of Addiction, Vol. 75, pp. 81-88, 1980 LOR-10722 Publication entitled "Effects of Varied Smoking Machine Parameters on 03/00/1983- Deliveries of Total Particulate Matter and Selected Smoke Constituents," W.S. 04/00/1983 Schlotzhauer, et al., J. of Analytical Toxicology, Vol. 7, March/April 1983 LOR-1 0723 Publication entitled "Salivary Cotinine; Frequency of Cigarette Smoking; and 00/00/1994 Body Mass Index: Findings at Baseline in the Lung Health Study," J.A. Istvan, et al., J. of Epidemiology, Vol. 139, No. 6, pp. 628-636, 1994 LOR-1 0724 Publication entitled "Conjugation Pathways in Nicotine Metabolism," M. 00/00/1991 Curvall, et al., Effects of Nicotine on Biological Systems, 1991 LOR-1 0725 Publication entitled "Cigarette yields of tar and nicotine and markers of 00/00/1993 exposure to tobacco smoke," D.B. Coultas, et al., Am. Rev. Respir. Dis., Vol. 148, pp. 435-440, 1993 LOR-10726 Publication entitled "Titrating exposure to tobacco smoke using cotinine - A 00/00/1990 minefield of misunderstandings," J.R. Idel, J. Clin. Epidemiology, Vol. 43, pp. 313-317, 1990 Page 26 of 79 98287948
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Exhibit Description: . Document Name: Date: LOR-10649 Deposition transcript of James L. Morton taken February 23, 1999, West 02/23/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10650 Deposition transcript of Brenda Pinti taken July 12, 1999, West Virginia-Ohion 07/12/1999 Valley Area I.B:E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10651 Deposition transcript of James M. Ross taken February 17, 1999, West . 02/17/1999 . Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10652 Deposition transcript of Michael R. Searls taken July 21, 1999, West Virginia- 07/21/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco. Company, et ai. (No. 2:97-0978) LOR-10653 Deposition transcript of Karen S. Short taken June 8; 1999, West Virginia-. 06/08/1999 Ohion Valley Area I.B'.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al: (No. 2:97-0978) LOR-1 0654 Deposition transcript of Ronnie L. Short taken June 22, 1999, West Virginia-- 06/22/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10655 Deposition transcript of Robert Eugene Smith taken June 28, 1999; West 06/28/1999 Virginia-Ohion Valley Area I.B.E.W.. Welfare Fund, et al. v. The American ' Tobacco Company, et al. (No. 2:97-0978) LOR-1 0656 Deposition transcript of Roger Larry Stewart taken July 26, 1999, West 07/26/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American - Tobacco Company, et al.(No. 2:97-0978) LOR-10657 Deposition transcript of James Lee Stubenrod taken March 11, 1999, West 03/11/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Compan , et al. No. 2:97-0978) LOR-10658 Deposition transcript of Carl J. Strikal taken June 3, 1999, West Virginia-Ohion 06/03/1999 Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10659 Deposition transcript of Kevin J. Van Camp taken July 26, 1999, West Virginia 07/26/1999 Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10660 Deposition transcript of Larry Wayne Wagner taken June 28, 1999;-West 06/28/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10661 Deposition transcript of Connie Wood taken May 11, 1999, International Union 05/11/1999 of Operating Engineers Local 132 Health and Welfare Fund v. Philip Morris, Inc., et al. (No. 3:97-0708) LOR-10662 Deposition transcript of Edmund Joseph Yahn, Sr., taken June 29,1999, West 06/29/1999 Virginia-Ohion Valley Area I.B.E.W. Welfare Fund, et al. v. The American Tobacco Company, et al. (No. 2:97-0978) LOR-10663 Explanation of Protocol Suspension; Rabbit Eye Irritation Test 12/31/1982 LOR-10664 Memorandum from F.J. Schultz to A.W. Spears regarding Testing of Tobacco 04/23/1.979 Additives LOR-10665 Index for Testing Program Master Book by H.J. Minnemeyer - 0 612 9/1 9 83 LOR-10666 Safety Evaluation and Advisory Committee Meeting Minutes 06/21/1983 OR-10667 Report regarding Testing Program for Cigarette Additives - 98287945 Page 23 of 79
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Exhibit Description: Document Name: Date: LOR-10747 Publication entitled "The Carbon-13 and Proton NMR Spectra of Nicotine and 09/00/1984 Aqueous Media," R.W. Slaven, The Journal of Heterocyclic Chemistry, Vol. 21 pp. 1329-1332, 1984 LOR-10748 Publication entitled "A High Performance Liquid Chromatographic Method to 01/00/1994 Quantify Phenolic Compounds in an Isopropanol Extract of Mainstream Cigarette Smoke," A. Prakash, et al., Tobacco Science, January 1994 LOR-10749 Presentation entitled "Sensory Evaluation of Sidestream Odor Using Transfer Testing Methodology," L.H. Gains, et al., TCRC Presentation LOR-10750 Publication entitled "Cigarette Smoke Tracers: Gas Chromatograph Analysis 00/00/1975 of Decachlorobiphenyl," C.I. Lewis, et aL, Am. Rev. of Respiratory Disease, Vol. 108, pp. 267-370, 1975 LOR-10751 Presentation entitled "Measurement of Ions in Whole Smoke," F.R. Perini,' et . 09/27/94 ;. al., Presentation to the 48th TCRC, Greensboro, NC, September 27, 1994 LOR-10752 Presentation entitled "The Fate of Radiolabeled Tartaric Acid in Burning 09/00/1994 Cigarettes," L.H: Gains, et al., Presentation at the 48th TCRC Conference, Greensboro, NC, Paper No. 34, September 1994 LOR-10753 Presentation entitled "Fresh Whole Smoke Mutagenicity Assay with YG 09/27/1994 Salmonella Strain," R.S. Lake, et al., Oral Presentation to TCRC, September 27, 1994 LOR-10754 Publication entitled "An Immunotoxicity Assessment of Food Flavoring 00/00/1994 Ingredients," C.L. Gaworski, et al., FD Chemical Toxicity, Vol. 32, No. 5, pp. 409-415, 1994 LOR-10755 Publication entitled "Developmental Toxicity Evaluation of Inhaled Citrel in 0 0/0 011 9 9 2 Sprague-Dawley Rats," C.L. Gaworski, et al., FD Chemical Toxicity, Vol. 30, No. 4, pp. 269-275, 1992 OR-10756: Publication entitled "Methods for the in vitro Assessment of Metal. Ion Toxicity," 00/00/1986 J.D. Heck, et al., Metal Ions in Biological Systems, Vol. 20, pp. 279-303, 1986 LOR-10757 Presentation entitled "Radiolabeling Synthesis and Resolution of L(+)- tartaric 00/00/19g1 Acid,and Its Fate in Cigarettes," L.H: Gains, et al., 45th TCRC, Paper No. 22, 1991 LOR-10758 Presentation entitled "Factors Affecting Smoke Delivery of Nicotine in Carbon< Monoxide," A.W. Spears LOR-10759 Publication entitled "Changes in Smoke Chemistry of Modern Day-Cigarettes;" 00/00/1982 V. Norman, Recent Advances in Tobacco Science, Vol. 8, pp. 141-177, 1982- LOR-10760 Publication entitled "Rapid Analysis of Menthol in Nicotine and Smoke and the 00/00/1982 Effects of Air Pollution on Delivery," R.A. Shoffner, et al., Tobacco Science, : No. XXVI, pp. 109-112, 1982 LOR-10761 Presentation entitled "Determination of Nicotine Contained in Cambridge Filter 00/00/197:7 Pads," J.R. Wagner, et al., Tobacco Chemists Research Conference, 1977 LOR-10762 Publication entitled "Recent Developments in Tobacco Smoke Analytical 0 0/0 011 9 7 7 Techniques," J.H. Bell, Proceedings from the ACS Symposium "Recent Advances in the Chemical Composition of Tobacco and Tobacco Smoke," 1977 . LOR-10763 . Presentation entitled "Identification of Certain Polyaeromatic Hydrocarbons in . 00/00/1970 Cigarette Smoke Condensate," J.H. Bell, et al., TCRC Program, 1970 LOR-10764 Publication entitled "An Automated Method for the Gas Chromatographic 00/00/1974 Determination in Nicotine and Smoke," J.R. Wagner, et al., Tobacco, Vol. 176, No. 11, pp. 69-72 Page 28 of 79 9$287ggO
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Exhibit Description: Document Name: Date: LOR-10887 Synetics Training Program Booklet, "Preparing for a Synetics Meeting," E. 00/00/1972 Rose LOR-10888 Letter from R.S. Goldbrenner to B. Richter regarding request to use cigarette 08/16/1974 television commercial LOR-10889 Letter from R. Robbins to J. Sherman regarding request for Folksong, U.S.A. 02/18/1976 books LOR-10890 Report "Lorillard Domestic Cigarette Marketing 5 Year Plan, 1977-1981," A.W. 09/00/1977 Spears LOR-10891 Letter from A.W. Spears to E. Colston regarding denial of sample favors for 01/24/1984 United Negro College Fund event LOR-10892 Letter from M.l. Gastman to Producing Managers Company regarding 09/22/1972 production of "The Secret Affairs of Mildred Wild" LOR-10893 Statement from R.B. Meyner to R.F. Kennedy regarding Cigarette Advertising 10/31/1967 Code LOR-10894 Letter from M. Yellen to R.B. Meyner regarding Lorillard's withdrawal from 03/25/1966 Advertising Code LOR-10895 Letter from P.R. Cotrone to L. Dinkin regarding youth advertising 07/24/1975 LOR-10896 Report "Confidential Newport Green 1982 Brand Plan," R.D. Hammer, et al. 12/00/1981 . LOR-10897 Memorandum from T.H. Mau to M.H. Burke, et al., regarding "Replies to Five 09/11/1981 Year Plan Questionnaire" LOR-10898 Memorandum from T.H. Mau to R.H. Orcutt, et al., regarding "Some Planning 07/07/1981 Toward 1982 Revised Five Year Planning Toward 1982 Revised Five Year Plan" LOR-10899 Publication entitled "Economic Report of the President, Annual Report of the 01/00/1987 Council of Economic Advisers". OR-10900 Publication entitled "Smoking and Health: A Report of the Surgeon General," 00/00/1979 pp. 17-15 and 17-16, 1979 LOR-10901 Report entitled "Some Initial Observations on the Patented Cigarette Project," pp. 1-15 LOR-1 0902 Presentation entitled "N-Alkylindoles; N-Alkycarpazoles; and Dibenzofurans in 00/00/1969 Cigarette Smoke," V. Mazzola, et al., Tobacco Chemists Conference, 1969 LOR-10903 Publication entitled "Smoking and Lung Cancer," C.C. Little, Cancer Research, 03/00/1956 Vol. 16, No: 3, pp. 183-184, March 1956 LOR-10904 Publication entitled, "Determination of Phenolic Constituents Who Cigarette 02/00/1963 Smoke by Gas Chromatography," R.H. Crouse, et al., The Journal of Gas Chromatography, pp. 18-22, February 1963 LOR-10905 Publication entitled "The Presence of 3:4 Benzpyrene in Cigarette Smoke," 11/13/1954 R.L. Cooper; et al., Chemistry & Industry, p. 1418, November 13, 1954 LOR-10906 Publication entitled "A study of cigarettes, cigarette smoke, and filters;" JAMA, 04/09/1955 Vol. 157, No. 15, pp. 1309-1311, April 9, 1955 - LOR-10907 Publication entitled "A study of cigarettes, cigarette smoke;-and filters," JAMA, 07/04/1953 Vol. 152, No..10, pp. 917-920, July 4, 1953 LOR-10908 Press release entitled "Lab Reports on Tar, Nicotine in Cigarettes," American 0410811955 Medical Association, April 8, 1955 LOR-10909 "Report to Surgeon General's Advisory Committee on Smoking and Health," 05/29/1963 1 May 28, 1963 from M: Cramer to J:M. Hundley LOR-10910 Memorandum from F. J. Schultz to A. W. Spears re NCI Nicotine Series 0 6/0 811 97 9 Cigarettes Page 34 of 79 98287956
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Exhibit Name: Description: Document Date: LOR-11239 How You Live May Save Your Life / Pregnant Mothers: Please Don't Smoke! / Are you short of breath 02/00/1986 VOR-1 124 Workers' Institute for Safety and Health / Cancer Hazard - CPSC Warns About Asbestos in Consumer Products 09/00i1986 LOR-11241 Asbestos Screening: A Necessary Ordeal 10/00/1986 LOR-1 1242 This Year Put an End to Your Dirty Habit 11/00/1986 LOR-1 1243 One of the biggest threats to your heart is right under your nose 02/0011987 LOR-11244 Don't Be Cruel to a Hearth That's True 08/00/1987 LOR-1 1245 AFL-CIO Safety Parley Maps Aggressive Programs I General Facts on Smoking and Health 01100/1988 LOR-1 1246 Asbestos Screening: It's Your Life at Stake 10/00/1988 LOR-1 1247 Work and Health - Questions & Answers About Strokes 0810 011 9 8 9 LOR-1 1248 Work & Health - Kicking the Smoking Habit / Don't Buy 12/00/1989 LOR-1 1249 The risk of dying in the prime of life is almost twice as great for men who are heavy cigarette smokers as for nonsmokers 12/00/1964 LOR-1 1250 Cancer of the Lung is Extremely Rare, the American Cancer Society Says / Scared Stiff 04/00/1966 LOR-11251 Could Be Oral Cancer 08/00/1966 LOR-1 1252 There are 18 million ex-smokers in the United States ... The American Cancer 01/00/1967 LOR-1 1253 Healthy Habits Really Help 01 /0 011 977 LOR-1 1254 Deaths From Heart Disease Take Dramatic Drop 12/00/1972 LOR-1 1255 A Personal Note From the President's Pen - Don't Smoke Cigarettes 02/00/1979 LOR-1 1256 The Battle Against Cancer Still Goes On 07100l1980 OR-11257 Ex Smokers Educate More 11/00/1974- 12/00/1974 LOR-1 1258 Minutes of the Tobacco Working Group Thirteenth Meeting 07/2 411 97 3 LOR-1 1259 Minutes of the Tobacco Working Group Eleventh Meeting 04/20/1972 LOR-1 1260 Minutes of the Tobacco Working Group Twelfth Meeting 1 1 /1 311 9 72 LOR-1 1261 Letter from Dr. Dietrich Hoffman to Dr. Alex Spears cc: Dr. EL: Wynder <. 0 3/2 611 9 6 9 LOR-1 1262 Letter from Dr. A.W. Spears to Dr: Dietrich Hoffman -- - 05/13/1960 LOR-11263 Letter from Dr. Dietrich Hoffman to Dr. E.L. Wynder, A. Goldman, Dr. P. Chan, cc: Dr. Spears 11/06/1968 LOR-11264 Letter from Dietrich Hoffman to Dr. C.O. Jensen 04/14/1965 LOR-11265 Letter from A.W. Spears to Dr. Earnest Wynder, cc: Drs. H.B. Parmele, C:O. Jensen, D. Hoffman, Mr. R. Ullrich with attachments 11/1011961 - LOR-1 1266 Report of Dr. D. Hoffman to Drs..E.L. Wynder, H.B. Parmele, A.W. Spears, "Testing of Tumor Promoting Activity of Subfractions of Neutral Portion of Cigarette Smoke Condensate" 05/14/1964 LOR-11267 Letter from Paul Schickedantz to Dr. E.L. Wynder, cc: Dr. Spears 12/08/1967 LOR-1 1270 Status Report Smoking and Health Program Division of Cancer Cause & Prevention National Cancer Institute 06/30/1974 LOR-11271 Cigarette Advertising Code, 1-8 00/00/1964 LOR-11272 Hill and Knowlton, 1-3, Cigarette Manufacturers Announce Advertising Code. 1964 Press Release. 04/28/1964 LOR-1 1273 Additional Views of the Honorable Thomas J. Bliley, Jr. on H.R. 3979, the Comprehensive Smoking Education Act 05/00/1984 OR-11274 Minutes of the Tobacco Working Group Fourteenth Meeting 04/08i1974 Page 47 of 79 98287969
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Exhibit Description: Document Name: Date: LOR-11301 Hallquist, J., et al., "Socioeconomic differences in risk of myocardial infarction 00/00/1998 1971-1994 in Sweden: time trends, relative risks and population attributable risks," Int J Epidemiol 27(3):410-415 (1998) LOR-11303 Howard, G., Goff, D.C., "A call for caution in the interpretation of the observed 00/00/1998 smaller relative importance of risk factors in the elderly," (Editorial) Ann Epidemiol 8(7):411-414 (1998) LOR-1 1304 La Vecchia, C., et al., "Attributable risk for stomach cancer in Northern Italy," 00/00/1995 Int J Cancer 60:748-752 (1995) LOR-1 1305 Last, J.M., ed., A Dictionary of Epidemiology. 3rd ed. New York: Oxford 00/00/1995 University Press, pp. 10, 11, 35, 118 (1995) LOR-1 1306 Morrell, S., et al., "Best estimate of magnitude of mortality due to occupational 00/00/1998 exposures to hazardous substances," Occup Environ Med 1998:634-641 LOR-1 1307 Northridge, M.E., "Public health methods-attributable risk as a link between 00/00/1995 causality and public health action," (Annotation) Am J Public Health 80:1202- 1203 (1995) LOR-11308 Rothman, K., et al., Modern Epidemiology, 2nd ed. Philadelphia: Lippincott- 00/00/1998 Raven, 1998, pp. 12-14, 24-28, 53-58, 296-297 LOR-1 1309 Sterling, T.D., et al., "Bias in the attribution of lung cancer as cause of death 00/00/1992 and its possible consequences for calculating smoking-related risks," Epidemiology 3(1):11-16 (1992) LOR-11311 Terry, P.E., et al., "Are health risks related to medical care charges in the 00/00/1998 short-term? Challenging traditional assumptions," Am J Health Promot 12(5):340-347 (1998) LOR-11312 Walter, S.D., "Effects of interaction, confounding, and observational error on 00/00/1983 attributable risk estimation," Am J Epidemiol 117:598-604 (1983) OR-11313 Walter, S.D., "Attributable risk in practice," Am J Epidemiol 148(5):411-413 00/00/1998 (1998) LOR-1 1314 Wilson, P.D., et al., "Attributable fraction for cardiac malformations," Am, J 00/00/1998 Epidemiol 148(5):414-423 (1998) LOR-1 1315 Greenland, S., et al., "Conceptual Problems in the Definition and Interpretation 00/00/1988 of Attributable Fractions," American Journal of Epidemiology 128(6):1185-97 (1988) LOR-1 1316 Kaufman, J.S., et al., "Socioeconomic status and health in blacks and whites: 00/00/1997 the problem of residual confounding and the resiliency of race," Epidemiology 8:621-628 (1997) LOR-11317 Kleinbaum, D.G., et al., Epidemiologic Research: Principles and Quantitative ` 00/00/1982 Methods, John Wiley & Sons, 1982 LOR-11319 McMichael, A.J., "Prisoners of the proximate: loosening the constraints on 00/00/1999 epidemiology in an age of change," Am J Epidemiol 149:887-897 (1999) LOR-1 1320 Morganstern, H., "Defining and explaining race effects," (Editorial) 00/00/1997 Epidemiology 8:609-611 (1997) LOR-1 1321 Mundt, K.A., et al., "Interaction: An epidemiological perspective for risk 00/00/1996 assessment," Toxicology and Risk Assessment: Principles, Methods, and Applications, pp. 329-351 (1996) LOR-1 1322 Rockhill, B., et al., "Use and Misuses of Population Attributable Fractions," Am 01/00/1998 J of Public Health 88(1):15-19; January 1998 LOR-11323 Schulman, J., et al., Smoking attributable mortality: Control for confounding. 02/01/1997 Final Report. Atlanta: Battelle, February 1, 1997 Page 49 of 79 98287971
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Exhibit Description: Document Name: Date: LOR-1 1056 Friedman, G.D., et aL, "Characteristics Predictive of Coronary Heart Disease 00/00/1979 in Ex-Smokers Before They Stopped Smoking: Comparison With Persistent Smokers and Nonsmokers," Journal of Chronic Diseases 32(1/2): 175-190 (1979) LOR-1 1057 Harrison's Principles of Internal Medicine, 13th Ed. Isselbacher, K.J., et al. 00/00/1994 (eds), McGraw-Hill, Inc. LOR-11058 Comprehensive Textbook of Thoracic Oncology. Aisner, J., et al. (eds), 00/00/1996 Williams & Wilkins. LOR-11059 Taubes, G., "Epidemiology Faces Its Limits - The Search,for Subtle Links 00/00/1995 Between Diet, Lifestyle or Environmental Factors and Disease is an Unending Source of Fear -But Often Yields Little Certainty," Science, 269, 1995, 164- 169. LOR-11062 Angell, M., Privilege and Health-What is the Connection?; New England 07/08/1993 Journal of Medicine, (1993) 329, 2:126-27 LOR-11063 Sackett, D, Bias in analytic research, J Chron Dis, 32:51-63, 1979 00/00/1979 LOR-1 1064 Wynder, E., "Workshop on Guidelines to the Epidemiology of Weak ' 00/00/1987 Associations." Preventive Medicine 16:139-212; 1987. LOR-1 1066 Textbook: Heart Disease: A Textbook of Cardiovascular Medicine, 1996 00/00/1996 Edition, author Eugene Braunwald. Philadelphia, W.B. Saunders Company, 1966 LOR-1 1067 Kierman, L "Alive and Well? A research and policy review of health programs 00/00/1991 for poor young children" New York: National Center for Children in Poverty, , Columbia University, 1991. LOR-1 1068 "Poll Refute Anti-Smokers' Claims That Industry-Sponsored Materials Are a 08/02/1993 Smoke Screen" OR-11071 "The Diagnostic Strategy for Lung Cancer - Has Determining Malignancy or 05/00/2000 Benignity Become More Accurate?" Chest 117(5)`.1219-1220 (2000) LOR-1 1072 "Four Million Adolescents Smoke: Or Do They?" Kovar, M:,' Chance 48(2):10- 00I00/2000 14 (2000) LOR-11074 Lung Cancer: Principles and Practice. Pass, H.I., et al. (eds). 00/00/1996 LOR-11075 Surgeon General's Report 00/00/1964 LOR-1 1076 A Report of the Surgeon General: The Health Consequences of Smoking: A 00/00/1967 Public Health Service Review LOR-11077 Report of the Surgeon General: The Health Consequences of Smoking 1968 00/00/1968 Supplement to the 1967 Public Health Service Review LOR-1 1078 A Report of the Surgeon General: The Health Consequences of Smoking: 00/00/1969 1969 Supplement to the 1967 Public Health Service Review LOR-1 1079 "The Health Consequences of Smoking, A Report to the Surgeon General: 00/00/1971 1971," U.S. Department of Health, Education and Welfare LOR-11080 "The Health Consequences of Smoking, A Report to the Surgeon General: 00/00/1972 1972," U.S. Department of Health, Education and Welfare LOR-1 1081 A Report of the Surgeon General: The Health Consequences of Smoking 00/00/1973 LOR-1 1082 A Report of the Surgeon General: The Health Consequences of Smoking 00/00/1974 LOR-1 1083 A Report of the Surgeon General: The Health Consequences of Smoking 00/00/1975 LOR-1 1084 A Report of the Surgeon General: The Health Consequences of Smoking: 00/00/1978 1977-1918 LOR-11085 "Smoking and Health: A Report of the Surgeon General," 1979 00/00/1979 OR-11086 "The Health Consequences of Smoking A Report of the Surgeon General " 00/00/1980 , , U.S. Department of Health and Human Services - Page 41 of 79 98287963
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Exhibit Description: Document Name: Date: LOR-11009 19. Zhu, B.P.; et al. "The Relationship between Cigarette Smoking and 11/00/1996. Education Revisited: Implications for Categorizing Persons' Educational Status" Am. J. Pub. Health, Vol. 86, No. 11, p. 1582-89 (November 1996) LOR-11010 Fertig, J.B., et al. "Health Behavior Correlates of Hazardous Drinking By Army 06/00/1996 Personnel" Military Medicine, Vol. 161, No. 6, p. 352-55 (June 1996). LOR-1 1011 Woodward, M., et al. "Deficient Health Knowledge, Diet, and Other Lifestyles. 0 0100/1 9 94 in Smokers: Is a Multifactorial Approach Required?" Preventive Medicine, . Vol. 23, No. 3, p. 354-61 (1994). LOR-11012 Stronks, K., et al., "Cultural, Material, and Psychosocial Correlates of the 00/00/1997 Socioeconomic Gradient in smoking Behavior among Adults" Preventive Medicine, Vol. 26, No. 5, Part 1, p. 754-66 (1997) LOR-11013 _ Holly, E.A., et al., "Characteristics of Women by Smoking Status in the San 00/00/1992 Francisco Bay Area" Cancer, Epidemiology, Biomarkers & Prevention, Vol. 1., N o. 6, p. 491-97 (1992). LOR-11014 Barclay, T.H. and Phillips, A.J., "The Accuracy of Cancer Diagnosis on Death 00/00/1962 Certificates," Cancer 15:5-9 (1962) LOR-11015 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, DSM-IV, 00/00/1994' American Psychiatric Association - LOR-11016 Bruce MacKay, M.D, Ph.D., et al., Tumors of The Lung, Adenocarcinoma, 00/00/1991 100-102 (Major Problems in Pathology vol. 24, 1991) LOR-11017 "Cancer of the Lung," Cancer: Principles & Practice of Oncology, 4th Ed. 00/00/1993 DeVita, V.T., et al. (eds), J.B. Lippincott Co. LOR-11018 Darryl Carter, M.D. & Joseph C. Eggleston, M.D., Atlas of Tumor Pathology, 0 010 0/1 9 8 0 Tumors of The Lower"Respiratory Tract, Second Series 113-115 & 119 (Armed Forces Institute of Pathology 1980) OR-11019 Burch, P., "Variance and Dissent: The Surgeon General's Epidemiologic 12/00/1983 - Criteria for Causality, A Critique," The Journal of Chronic Diseases 36(12): : 821-836, at 833-834 (Dec. 1983) LOR-11020 . Brownlee, K. A., "A Review of Smoking and Health," Journal of the American 09/00/1965-- Statistical Association 60 (311): 722-739 (Sept. 1965) LOR-11021 . Textbook of Respiratory Medicine, 2nd Ed. Murray, J.F. and J.A: Nadel (eds), 00/00/1994 W.B. Saunders Co. LOR-1 1022 National Cancer Institute Smoking and Health Program, Report #3, toward less hazardous cigarettes, the third set of experimental cigarettes, Dept. of Health, Education and Welfare. LOR-11023 Whichelow, M.J., et al., "A Comparison of the Diets of Non-Smokers and 00/00/1991 ° Smokers," British Journal of Addiction 86(1);.71-81 (1991) LOR-11024 Thomas, C.B., "Personality Differences Between Smokers and Nonsmokers,", 05/00/1978., Maryland State Medical Journal 27(5): 63-66 (May 1978) LOR-11025 • Hearings Before the Select Committee on Nutrition and Human Needs, United 07/28/1976 States Senate, "Diet Related to Killer Diseases" LOR-11026 "Bronchioloalveolar Carcinoma," Journal of Clinical Oncology, Barkley and 0 8/0 011 9 9 6 - Green LOR-1 1027 "Rising Incidence of Bronchioloalveolar Lung Carcinoma and Its Unique 0 2 /1 511 9 94 - Clinicopathologic Features," Cancer, Barsky, Cameron, Osann, et al. LOR-11028 Wynder, E, Workshop on guidelines to the epidemiology" of weak associations, 0 0/0 011 9 8 7 J Prev Med, 16:139-41; 1987 OR-1 1029 Weak associations in epidemiology and their interpretation, Conference 00/00/1982 Report, American Health Foundation, J Prev Med, 11:464-476, 1982 Page 39 of 79 98287961
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Exhibit Name: Description: Document Date: LOR-1 1133 The Gallup Poll: American Institute of Public Opinion, Subject: Health Information, "Do you think cigarette smoking is one of the causes of cancer of the lung?" 07/0011957 LOR-11134 The Gallup Poll: American Institute of Public Opinion, Subject: Health Information 06/2411969 LOR-11135 Letter from William Metscher of Enviro Control, Inc. to Dr. Frederick J. Schultz of Lorillard re Nicotine Titration Study 08/28/1978 LOR-1 1136 Letter from William Metscher of Enviro Control, Inc. to Dr. Frederick J. Schultz of Lorillard re Nicotine Titration Study 05/23/1978 LOR-11137 Jenkins, R. A.; Quincy, R. B.; Marshall, A. H.; Topical Report, Chemical Analysis of Smoke from "B" Series Cigarettes for Harvard Medical School Nicotine Accommodation Study 04/30/1979 LOR-11138 Jenkins, R. A.; Quincy, R. B.; Marshall, A. H.; Topical Report, Chemical,. Analysis of Smoke from "B" Series Cigarettes for Harvard Medical School Nicotine Accommodation Study 04 /3 011 9 7 9 LOR-11139 Jenkins, R. A.; Quincy, R. B.; Marshall, A. H.; Additional Investigations, Smok Constituent Deliveries - B Series Cigarettes, Harvard Medical School Nicotine Accommodation Study 0 711 711 9 7 9 LOR-1 1140 Federal Trade Commission's Report of Tar and Nicotine Content of the Smoke of 176 Varieties of Cigarettes 12/00/1979 LOR-1 1141 Letter to the editor of Fortune Magazine describing how causation has not been proven; Luchtenberger 01 /0 811 9 69 LOR-11142 It's the Law (Photo of Decal) 09/00/1990 LOR-11144 ...On Youth Smoking - Tobacco Advertising ... And Why Kids Smoke 09I00/1990 LOR-11145 Minutes of the Tobacco Working Group Meeting 03/10/1976 OR-11146 TI Publication "Smoking Should Not Be A Part of Growing Up.", 00/00/1990 LOR-11147 TI Publication: "It's the Law. We Do Not Sell Tobacco Products to Persons Under 18." 00/00I1990 LOR-1 1148 Advertising Schedule for "Helping Youth Say No." 0D100/1990 LOR-1 1149 TI Publication "What's The Tobacco Industry Doing About Smoking?" ~ 00/00/1990 LOR-1 1150 "Tobacco: Helping Youth Say No" Summary of Poll Results 1 0 0/0 011 9 93 LOR-1 1151 Tobacco: Helping Youth Say Nb: A Parent's Guide to Helping Teenagers Cope With Peer Pressure 00/00/1993 LOR-1 1152 It's the Law We Do Not Sell Tobacco Products to Persons Under 18 00/00/1993 LOR-1 1153 Proposed 1993 Ad Schedule 00/00/1993 LOR-1 1154 Tobacco Update "The Tobacco Industry's Commitment to Discourage Youth Smoking" 00/00/1993 LOR-1 1155 Family C.O.U.R.S.E Consortium Mission Statement 00/00/1993 LOR-1 1156 From: Family C.O.U.R.S.E. Consortium to Public Service Director 00/00/1993 LOR-11157 "It's Tough Growing Up" 00/00/1993 LOR-1 1158 Tobacco "Helping Youth Say No" "Parent to Parent" 00/00/1993 LOR-11159 "Smoking Should Not Be A Part of Growing Up" 00/00/1993 LOR-1 1160 Tobacco "Helping Youth Say No" "Growing Up" 00I00/1993 LOR-1 1162 Tobacco Institute "Thanks A Million!" 00/00/1993 LOR-11163 Tobacco Institute "Is This Sign In Your Window?" . 00/00/1993 LOR-11164 Cigarette Advertising and Promotion Code 12/00/1992 LOR 11165 To: The Members of The Management Committee From: Samuel Chilcote 10/30/1992 -" Page 44 of 79 98287966
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Exhibit Name: Description: Document Date: LOR-1 1196 Your Lungs Will Last as Long as You Life. And Vice Versa 07/00/1973 LOR-11197 Cold Weather Health Tips 01/00/1992 OR-11198 If You Quit Smoking 03/00/1999. LOR-11199 An Ironworker Guide to Asbestos Exposure 01/00/1979 LOR-1 1200 A Very Personal Gift 04/00/1991 LOR-11201 Your Job and Your Health 06/00/1979 LOR-1 1202 What Do You Know About the Nationsl Number One Health Enemy 02/00/1972 LOR-11203 Reduce Your Risk of Heart Attack 02/00/1970 LOR-1 1204 Ask the Doctors ... Smoking: the Single Worst Thing You Can Do to Yourself 02/00/1978 LOR-1 1205 Best tip yet: Don't Start! [photo & caption] in The Trades Union 09/20/1975 LOR-11206 All we can tell you...[p.s.a.] 03/27/1976 LOR-11207 . The Puzzle of Cancer - American Cancer Society 04/00/1969 LOR-1 1208 Hypertension - What you don't know can hurt (or kill) you! - 05/00/1979 LOR-11209 Heart Disease: The Silent Killer 02/00/1985 LOR-11210 These Earth people can't be intelligent beings if they smoke those things [Cartoon] in the International Teamster 06/00/1968 LOR-1 1211 About your HEART ... - 05/00/1950 LOR-11212 The CigarMakers Story 07/00/1953 LOR-11213 Asbestos - 01100/1979 LOR-1 1214 Safety Tips for You and Your Family 05/00/1979 LOR-11215 Your Job and Your Health: A Smoke Screen 06/00/1979 LOR-11216 Reduce Your Risk of Hearth Attack (adv.) . 02/00/1972 LOR-1 1217 Asbestosis Screening Program Initiated and A Long, Health Life is Within Everyone's Reach 04/00/1987° - OR-11218 Health-Protection Program in Illinois; and IBEW Well Represented at National Safety Council Labor Division meeting 08/00/1985 LOR-11219 New Years Resolutions for You and Your Family's Health and Safety 12/00/1986 LOR-11220 Smoking Banned at Meetings . 05/00/1988 LOR-1 1221 Asbestos: If you Have Been Exposed ... LOR-11222 Am I Having A Heart Attack? 08/00/1984 LOR-1 1223 Asbestos: The Silent Killer 04/00/1983 LOR-1 1224 Nationwide Cancer Crusade to Reach Climax This Month . 04/0 011 9 6 9 LOR-1 1225 Expert Answers Vital Questions on Cancer - 01/00/1969 ° LOR-1 1226 Reduce Your Risk of Heart Attack 01/00/1970 LOR-11227 Are you on this spot? 02/00/1971 LOR-11228 Reduce your risk of Heart Attack! 07/00/1977 LOR-11229 High Blood Pressure Hits One in Six 05/00/1979 LOR-1 1230 The Battle Against Cancer Still Goes On - A Special Report 07/00/1980 LOR-11231 A Self Test to Determine Your Style of Health 10/00/1981 LOR-1 1232 Ammonia Can Be Dangerous; Don't Buy 06/00/1983 LOR-1 1233 Stroke: Prevention Is the Key; We're Looking for Trouble 05/00/1984 LOR-11234 Questions & Answers on Blood Pressure 08/00/1984 LOR-1 1235 Cancer Prevention Quiz; Playing It Safe In The Fitness Game 1 1 /0011 984 LOR-11236 Controlling High Blood Pressure . 11/00/1985 LOR-11237 How you live may save your life 02I00/1985 LOR-11238 Medical Bills Don't Have to Cost an Arm and a Leg/How Good Are Your Chances for Staying Healthy; Join the Great American Smoke Out 11/00/1985 Page 46 of 79 98287968
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Exhibit Description: Document Name: Date: LOR-10961 Campos-Outcalt, D.E., Accuracy of ICD-9-CM Codes in Identifying Reportable 0 0/0 011 9 9 0 Communicable Diseases; Qual Assur Util Rev, Vol. 5(3), 86-89 (1990). OR-10962 Britton, M., Diagnostic Errors Discovered at Autopsy; Acta med. Scand, 00/00/1974 196:203-210 (1974). LOR-1 0963 Goldman, L., Sayson, R., Robbins, S., Cohn, L.H., Bettmann, M., Weissberg, 04/28/1983 M., The Value of the Autopsy in Three Medical Eras; N Eng J of Med, Vol. 308(17):1000-1005 (April 28, 1983). LOR-10964 McFarlane, M.J., Feinstein, A.R., Wells, C.K., Necropsy Evidence of Detection 09/00/1986 Bias in the Diagnosis of Lung Cancer; Arch Intern Med, Vol. 146:1695-1698 (September 1986). LOR-10965 Battle, R.M., Pathak, D., Humble, C.G., Key, Vanatta, P.R., Hill, R. B., 07/17/1987 Anderson, R.E., Factors Influencing Discrepancies Between Premortem and Postmortem Diagnoses; JAMA, Vol. 258(3):339-344 (July 17, 1987) LOR-10966 Veress, B., Alafuzoff, I., A Retrospective Analysis of Clinical Diagnoses and 02/00/1994 Autopsy Findings In 3,042 Cases During Two Different Time Periods; Human Pathology, Vol. 25(2):140-145 (February 1994) LOR-10967 Manzini, V.P., Revignas, M.G:, Brollo, A., Diagnosis of Malignant Tumor: 03/00/1995 Comparison Between Clinical and Autopsy Diagnoses, Human Pathology, Vol. 26(3):280-283 (March 1995) LOR-10968 Robinson, I.A., Marley, N.J.E., Factors predicting cases with unexpected 00/00/1996 clinical findings at necropsy; J. Clin Pathol, Vol. 49:909-912 (1996) LOR-10969 Kirch, W., Schafti; C., Misdiagnosis at a University Hospital in 4 Medical.Eras: 00/00/1997 Report on 400 Cases; Medicine, Vol. 75(11), 1694-1698 (1997) LOR-10970 Bernicker, E.H., Atmar, R.L., Schaffner, D.L., Greenberg, S.B:, Unanticipated 05/00/1996 Diagnoses Found at Autopsy in an Urban Public Teaching Hospital; AJMS; Vol. 311(5):215-220 (May 1996). LOR-10971 Nichols, L., Aronica, P., Babe, C., Are Autopsies Obsolete?; Am. J. Clin. 00/00/1998 Pathol., 110:210-218 (1998). LOR-10972 Howard, B., Lee, Elisa; Fabsitz, R.; Robbins, D., Yeh, J.; Cowan, L.; Welty, T.; 07/00/1996 Diabetes ad CoronaryNeart Disease in American Indians: The Strong Heart Study," Diabetes, Vol. 45, Suppl. 3S6-S13 LOR-10973 Hopkins, P.; Williams, R.; A Survey of"246 Suggested Coronary Risk Factors," 12/08/1980 Atherosclerosis, 40 (1981) 1-52 LOR-10974 Welty, T.K., et at., "Cardiovascular Disease Risk Factors among American 00/00/1995 Indians, The Strong Heart Study," Am. J. Epidemiology, Vol. 142, No. 3 (1995) LOR-10977 "An overview of the Risk Factors for Cardiovascular Disease," Chapter 1 of 00/00/1983 Prevention of Coronary Heart Disease: Practical Management of the Risk Factors, 1983 LOR-10978 "Systematic review of randomized controlled trials of multiple risk factor 06/07/1997 interventions for preventing coronary heart disease," BMJ, Vol. 314, June 7, 1997 LOR-10979 "Framingham Study Data and 'Established Wisdom' About Cigarette Smoking 00/00/1989 and Coronary Heart Disease," J Clin Epidemiol, Vol. 42, No. 8, 1989 LOR-10980 "An Updated Coronary Risk Profit, A Statement for Health Professionals," 01/00/1991 Circulation, Vol. 83, No. 1, January 1991 LOR-10981 "The Health Risks of Smoking, The Framingham Study: 34 Years of Follow- 07/00/1993 up," AEP, Vol. 3, No. 4, July 1993 . 98287959 Page 37 of 79
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Exhibit Description: Document Name: Date: LOR-11275 Note from A.J. Stevens re "Cigarette Sampling: Seven Essential Principles in 10/20/1983 Sampling Procedure" OR-11276 Hollow Cigarette, U.S. Patent No. 5,690,127, dated 11/25/97 11/25/1997 LOR-11277 Hill and Knowlton, 1-3, Former Governor Robert B. Mayner.Selected as 06/08/1964 Administrator of Cigarette Advertising Code LOR-1 1278 Statement issued by Dr. Alexander W. Spears through the Tobacco Institute o 04/13/1994 Research to Waxman's press conference LOR-11279 Statement to Andrew Tisch at Waxman 04/14/1994 LOR-1 1280 Statement of Alexander W. Spears. Response to accusations at Waxman 0312511994 hearing LOR-1 1281 "Less Harmful Ways of Smoking," Report of 2nd World Conference on 09/24/1971 Smoking and Health LOR-11282 Memorandum from E.A. Harrow to L.M. Giordano re Youth Action Program 11/28/1990 LOR-11283 Transmittal of Industry Code of 1990 from Andrew Tisch 01/15/1991 LOR-11284 New Jersey Statutes, Section 2A:170-51, 1971 00/00/1971 LOR-11285 Memorandum from Judge to Achey re "Newport" LOR-11286 Section 2A:170-51. New Jersey Statutes, 1952 .- 00/00/1971 LOR-11287 New Jersey Statutes, Section 2A: 170-51, 1987 Legislation Historical and 00/00/1987 Statutory Notes: L. 1987, c. 423, Section 1 LOR-11288 Pennsylvania State; Pa Consolidated Statutes Annotated, Title 18; Section 00/00/1973 6305. Sale of Tobacco (PA ST 19 Pa. C.S.A. Section 6305. Sale of Tobacco. 1972, Dec. 6, P.L. 1482, No. 334, Section 1, effective June 6, 1973.) LOR-11289 Pennsylvania State, Pa Consolidated Statutes Annotated, Title 18, Section 00/00/1998 6305. Sale of Tobacco (PA ST 18 Pa. C.S.A. Section 6305. Sale of Tobacco. 1998) OR-11290 Letter from Orlowsky to Bluestein re public statements by Harley Davidson • 10/22/1993 LOR-11291 Letter to Hoelton [Hoelter] from Goldbrenner re Harley Davidson Trademark. 09/03/1993 License LOR-11292 Alavanja, MCR, et al., "Attributable risk of lung cancer in lifetime nonsmokers 0 0/0 011 9 9 5 and long-term ex-smokers (Missouri, United States)," Cancer Causes Control 6:209-216 (1995) LOR-11293 Bailar, JCI, et al., "Cancer undefeated," N Engl J Med 336(22):1569-1574 . 00/00/1998 (1998) LOR-11294 Benichou, J., "Methods of adjustment for estimating the attributable risk in 00/00/1991 case-control studies: A review," Stat Med 10:1753-1773 (1991) LOR-11295 Benichou, J., et al., "Population attributable risk of renal cancer in Minnesota," 00/00/1998 Am J Epidemiol 148(5):424-430 (1998) LOR-1 1296 Boffetta, P., et al., "Alcohol drinking mortality among men'enrolled.in an 00/00/1990 American Cancer Society prospective study," Epidemiology 1(5):342-348 (1990) LOR-11297 Brown, L.M. "Are racial differences in squamous cell esophageal cance et al. 00/00/1994 , , explained by alcohol and tobacco use?" J Natl Cancer Inst 86(17):1340-1345 (1994) . . LOR-11298 Bulterys, M., et al., "Quantifying the expected vs. potention impact of a risk- 00/00/1997 factor intervention program," (Letter) Am J Public Health 87:867-868 (1997) LOR-11299 D'Avanzo B., et al., "Attributable risks for bladder cancer in Northern Italy,"- . 00/00/1995 Ann Epidemiol 5(6):427-431 (1995) OR-11300 Diez-Roux, A.V., "On genes, individuals, society, and epidemiology," Am J 00/00/1998 Epidemiol 148(11):1027-1032 (1998) - = Page 48 of 79 98287970
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Exhibit Description: Document Name: Date: LOR-1 1166 Memo to Members of the Executive Committee and Management Committee 09/14/1992 from Samuel D. Chilcote on Youth Smoking LOR-11167 Letter to Louis Sullivan From Samuel Chilcote on Discouraging Youth 08/28/1992 Smoking LOR-11168 C.O.U.R.S.E. Consortium News Release on "Smoking Should Not Be a Part o 02I04/1992 Growing Up" LOR-11169 Tobacco Institute Proposes "Frontline Partnership" with City and State 05/01/1991 Legislators to Help Curb Cigarette Sales to Inner City Youth LOR-11170 Tobacco: Helping You Say No. A Parent's Guide to Helping Teenagers Cope 00/00/1991 With Peer Pressure; The Tobacco Institute LOR-11171 "It's the Law: Tobacco Product Retailing Program for Retail/Vendor Industry" 00/00/1991 LOR-1 1172 Cigarette Advertising and Promotion Code 12/00/1990 LOR-11173 Publication entitled Smoking and Health, A Program to Reduce the Risk of 12/01/1979 Disease in Smokers, Status Report - December 1979, National Cancer Institute, National Heart, Lung and Blood Institute, National Institutes of Health ` LOR-1 1174 Publication entitled Smoking and Health, A Program to Reduce the Risk of . 12/01t1977 Disease in Smokers, Status Report - December 1977, National Cancer Institute, National Heart, Lung and Blood Institute, National Institutes of Health . LOR-11175 Publication entitled Smoking and Health Program, National Cancerlnstitute, 01/01/1977 Status Report, January 1977. LOR-11176 1956 Report of the Scientific Director; C.C. Little 0010011956 LOR-1 1177 Public Symposia in Which the Council For Tobacco Research - USA Has 01/16/1960 Participated LOR-1 1178 Informal Scientific Conferences Sponsored By The Council For Tobacco Research - U.S.A. OR-11179 "It's the Law" -- No selling to minors campaign LOR-1 1180 "Statement of Policy Containing Conditions and Terms Under Which Project. 00/00/1969 Grants Are Made," CTR LOR-1 1181 Feinstein, A. R., "Clinical Biostatistics: XLVII. Scientific Standards v. 04100/1 9 7 9. Statistical Associations and Biologic Logic in the Analysis of Causation. Clinical Pharmacology and Therapeutics 25(4): 481-492, at 483 (April (1979) , LOR-11182 Hammond, Dr: E. Cuyler, "Is There Proof That Smoking Causes Lung 0212611954 Cancer?", Interview in U.S. News & World Report, pp. 62-71 (Feb. 26, 1954);., - at62 LOR-11184 Washington Post (Aug. 10 (1978) quoting Gori 0811 0/1 9 7 8 LOR-1 1185 Safety and Health: Fitness, Health, and Nutrition 01/00/1989- 02/00/1989 LOR-1 1186 Great American Smokeout Advertisement: Give Smoking a Kick in the Butt 09/00/1987- 10/00/1987 LOR-11187 American Heart Association: Heart Answers LOR-11188 American Heart Association: Heart Answers LOR-11189 Don't Smoke Today - November 20, 1980 11/00/1980 LOR-11190 A Word on Cancer 04/00/1968 LOR-11192 How To Prevent Coronary Heart Disease 11/00/1964 LOR-1 1193 12 Health Resolutions for 1966 . 02/00/1965 LOR-11194 People and Places (Third Item) in Steel Labor: The Voice of United 04/0011976 Steelworkers of America OR-11195 Smoking and Dental Care Spotlight 09/00/1969 gS2S7g67 Page 45 of 79
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Exhibit Description: Document Name: Date: LOR-1 1463 Multiple Risk Factor Intervention Research Group, "Multiple Risk Factor 00/00/1982 Intervention Trial: Risk factor changes and mortality results," JAMA 248:1465- 1477 (1982) LOR-1 1464 Multiple Risk Factor Intervention Research Group, "Mortality after 16 years for 00/00/1996 participants randomized to the Multiple Risk Factor Intervention Trial," Circulation 94:946-951 (1996) LOR-1 1465 Murray, D.M., "Design and analysis of community trials: Lessons learned from 00/00/1995 the Minnesota Heart Health Program," Am J Epidemiol 142:269-575 (1995) LOR-11466 Naslund, G.K., "Relationships between health behavior, knowledge, and 0 0100/1 9 97 beliefs among Swedish blue-collar workers," Scan J Soc Med 25:100-110 (1997) LOR-11467 Nieto, F.J., "Cardiovascular disease and risk factor epidemiology: a look back 00I00/1999 at the epidemic of the 20th century," (editorial) Am J Public Health 89:292-294 (1999) LOR-1 1468 Nourjah, P., et al., "Knowledge of risk factors and risk behaviors related to 00/00/1994 coronary heart disease among blue and white collar males," J Public Health Policy 15(4):443-459 (1994)' LOR-1 1469 Pearson, T.A., Pyorala, K., "Section III: Trends in CHD in.selected countries- 00/00/1989 overview," Int J Epidemiol 18(Suppl. 1):S99-S100 (1989) LOR-11470 Pekkanen, J., et al., "Social class, health behaviour, and mortality among men 00/00/1995 and women in eastern Finland," BMJ.311:589-593 (1995) LOR-1 1471 Rose, G., " Causes of the trends and variations in CHD mortality in different 00/00/1989 countries," Int J Epidemiol 18(Suppl. 1):S174-S179 (1989) LOR-1 1472 Rose, G., et al., "Life events, mood, mental strain and cardiovascular risk 00/00/1998 factors in Swedish middle-aged men. Data from the Swedish part of the Renault/Volvo Coeur Study," Occup Med 48:329-336 (1998) LOR-1 1473 Rose, G., Colwell, L., "Randomized controlled trial of anti-smoking advice: 00/00/1992 final (20 year) results," J Epidemiol Comm Health 46:75-77 (1992) LOR-11474 Rose, G., Hamilton, P.J.S., "A randomized controlled trial of the effect on .. 0 0/0 011 9 78 middle-aged men of advice to stop smoking," J Epidemiol Comm Health . 32:275-281 (1978) LOR-1 1475 Rose, G., et al., "A randomized controlled trial of anti-smoking advice: 10-yr. 00/Q011982 results," J Epidemiol Comm Health 36:102-108 (1982) LOR-1 1476 Rothenberg, R., et al:, "9schemic heart disease.prevention: estiniating the 00/00/1992 impact of interventions," J Clin Epidemiol 45:21-29 (1992) LOR-1 1477 Serxner, S., et al., "Influences on cigarette smoking quantity. :Selection, - 00/00/1992 stress, or culture?," J Occup Med 34:934-939 (1992) LOR-1 1478 Siegrist, J., et al., "Low status control, high effort at work and ischemic heart 00/00/1990 disease: prospective evidence from blue-collar men," Soc Sci Med 31:1127- 1134 (1990) LOR-1 1479 Stamler, J., "Opportunities and pitfalls in international comparisons related to 0010011989 patterns, trends and determinants of CHD mortality," Int J Epidemiol 18(Suppl. 1):S3-S18 (1989) LOR-1 1480 Strandberg, T.E., et al., "Long-term mortality after 5-Year Multifactorial Prima 00/00/1991 Prevention of Cardiovascular Disease in Middle-Aged Men," JAMA 266:1225- 1229 (1991) LOR-1 1481 Strandberg, T.E:, et al., "Mortality in participants and non-participants of a, 00/00/1995 multifactorial prevention study in cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study," Br Heart J 74:449-454 (1995) 98287974 ! Page 52 of 79
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Exhibit Name: Description: Document Date: LOR-11584 Tobacco Is Wacko If You're A Teen 00/00/1999 LOR-11585 Some Things Are Hard To Discuss With Your Child. Smoking Shouldn't Be One Of Them 00/00/1999 LOR-11586 Some Things Are Hard To Discuss With Your Child. Smoking Shouldn't Be One Of Them 00/00/1999 LOR-1 1587 Some Things Are Hard To Discuss With Your Child. Smoking.Shouldn't Be One Of Them 00/00/1999 LOR-11588 Take 10 Tips For Youth Smoking Prevention 00/00/1999 LOR-1 1589 Comments Regarding Regulatory Provisions and Warning Labels 10/01/1997 LOR-11590 Take 10 Start Talking So Your Kids Don't Smoke 00/00/1999 LOR-11591 Corporate Principles on Marketing, Promotion and Youth Smoking 00/00/1999 LOR-1 1592 Proclamation - 991120 is Take 10 Day In Dallas - Youth Smoking Prevention 11/20/1999 LOR-1 1593 Take 10 Day 990000 By The Governor of the State of North Carolina. A Proclamation 11100/1999 LOR-1 1594 City of Charlotte, North Carolina Proclamation - 991030 Is Take 10 Day - Youth Smoking Prevention 10/30/1999 LOR-11595 City of Philadelphia Proclamation - 991030 is Take 10 Day - Youth Smoking Prevention 10/30/1999 LOR-11596 Proclamation - 991029 is Take 10 Day in Chicago - Youth Smoking Prevention 10/15/1999 LOR-11597 Lorillard Youth Smoking Prevention Campaign Quantitative Campaign Evaluation 07/20/1999 LOR-11598 Smoking Prevention Campaign Copy Test for the Executions Stereo and Piercing Parlor - Report - Number 99-049 08/25/1999 LOR-11599 Teen h.i.p. "Teens Helping Influence People Awards," Poster 00/00/1999 OR-11600 Website: www.buttoutnow.com Teens Helping Influence People 00/00/1999 OR-11601 Website: 2takelO.com\Take 10 website Start Talking So YourKids Don't Smoke 00/00/1999 LOR-11602 WWF, "Tobacco Is Wacko If You're A Teen" 12I00/1999 LOR-1 1603 Gamepro Magazine, "Tobacco Is Wacko If You're A Teen" 12/00/1999 . LOR-1 1604 Teen People, "Tobacco Is Wacko If You're A Teen" 01/00/2000 LOR-11605 NBA Inside Stuff, "Tobacco Is Wacko If You're A Teen" 05/00/2000 LOR-11606 Electronic Gaming Monthly, "Tobacco Is Wacko If You're A Teen" 05/00/2000 LOR-11607 Teen People, Advertisement for Teen Helping Influence People Award Scholarship 02/00/2000 LOR-11608 Parents, Advertisement "Some Things Are Hard To Discuss With Your Child, Smoking Shouldn't Be One of Them" 05/00/2000 LOR-1 1609 Six Flags Official Park Mag and Guide 2000, "Tobacco Is Wacko If You're A Teen" _ 00/00/2000 LOR-11610 The Lorillard Informer, 1990500-19990600; Vol. 25, No. 3 06/00/1999 LOR-29000 "The Health Consequences of Smokeless Tobacco," 1986, A Report of the Advisory Committee to the Surgeon General 00/00/1986 LOR-29001 "The Health Consequences of Smoking: Nicotine Addiction," 1988, A Report of the Surgeon General 00/00/1988 LOR-29002 Report of the Surgeon General of the United States, 1982 00/00/1982 LOR-29003 Armitage, A., et al., "Absorption of Nicotine from Small Cigars,." Clin Pharmaco Ther 25(2):143-151 (1978) 00/00/1978 L OR-29004 Armitage, A.K. and Turner, D.M., "Absorption of Nicotine in Cigarette and Cigar Smoke Through the Oral Mucosa," Nature 226:1231-1232 (1970) 00/00/1970 - Page 56 of 79 98287978
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Exhibit Description: Document Name: Date: LOR-11441 Browner, W.S., "Estimating the impact of risk factor modification programs," 00/00/1986 Am J Epidemiol 123:143-153 (1986) OR-11442 Buring, J.E., et al., "Occupation and risk of death from coronary heart 00/00/1987 disease," JAMA 258:791-792 (1987) LOR-11444 Emmons, K.M., et al., "Mechanisms in multiple risk factor interventions: 00/00/1994 smoking, physical activity, and dietary fat intake among manufacturing workers," Work Well Research Group. Prev Med 23:481-489 (1994) LOR-11445 Fortmann, S.P., et al., "Community intervention trials: reflections on the 00/00/1995 Stanford Five-City Project Experience," Am J Epidemiol 142:576-586 (1995) LOR-11446 Gupta, S., Camm, A.J., "Chlamydia pneumoniae and coronary heart disease: 00/00/1997 coincidence, association, or causation?," (editorial).BMJ 314:1778-1779 (1997) LOR-11447 Hall, E.M., et al., "Women, occupation, and risk of cardiovascular morbidity , 00/00/1993 and mortality," Occup Med: State of the Art Reviews 8:709-719 (1993) LOR-1 1448 Harlan, W., "CHD trends in the United States: Overview," Int J Epidemiol 00/00/1989 18(Suppl 1):S56-S57 (1989) LOR-11449 Hebert, P.R., et al., "Occupation and risk of nonfatal myocardial infarction,"- 00/00/1992 Arch Intern Med 152:2253-2257 (1992) LOR-1 1450 Higgins, M., Thom, T., "Trends in CHD in the United States," {nt J Epidemiol 00/00/1989 18(Suppl 1):S58-S66 (1989) LOR-1 1451 Hjermann, I., "The Oslo Study: Some Trial Results," In Leaf, A., Weber, P.C., 00/00/1990 eds. Atherosclerosis Reviews, Vol. 21, New York: Raven Press, Ltd., 103- 108 (1990) LOR-11452 Howard, G., et al., "Role of social class in excess black stroke mortality," : 00/00/1995 Stroke 26(10):1759-1763 (1995) OR-11453 Koepsell, T.D., et al., "Invited Commentary: Symposium on Community 00/00/1995 Intervention Trials," Am J Epidemiol 142:594-599 (1995) LOR-11454 Luepker, R.V., et al., "Socioeconomic status and coronary-heart disease risk 00/00/1993 factor trends. The Minnesota Heart Survey," Circulation 88:2172-2179 (1993) LOR-11455 Marmot, M.G., et al., "Employment grade and coronary heart disease in British 00/00/1978 civiCservants," J Epidemiol, Community Health 32:244-249 (1978) - LOR-11456 Marmot, M.D., "Life style and national and international trends in coronary 00/00/1984 heart disease mortality," Postgraduate Med J 60:3-8 (1984) LOR-11457 Mattila, K.J., et al., "Role of infection as a risk factor for atherosclerosis, 00/0011998 myocardial infarction, and stroke,".Clin Infect Dis26:719-734 (1998) LOR-11458 McKinlay, J.B., et al., "A tale of 3 tails," (editorial) Am J Public Health 89:295r 00/00/1999 298 (1999) LOR-1 1459 Menotti, A., et al., "Inter-cohort differences in coronary heart disease mortality 00/0011993 in the 25-year follow-up of the Seven Countries Study," Eur J Epidemiol 9:527- 536 (1993) ' LOR-11460 Miettinen, T.A., et al., "Multifactorial primary prevention of cardiovascular 00/00/1985 disease in middle-aged men," JAMA 254:2097-2102 (1985) LOR-11461 Miller, F.D., et al., "Mortality and morbidity among blue and white collar 00/00/1993 workers in the Honolulu Heart Program cohort," Int J Epidemiol 22:834-837 ` (1993) LOR-11462 Morgenstern, H., Bursic, E.S., "A method for using epidemiologic data to ' 00/00/1982 estimate the potential impact of an intervention on the health status of a target population," J Community Health 7:292-309 (1982) , _--- Page 51 of 79 98287973
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Exhibit Description: Document Name: Date: LOR-1 1324 Sterling, T.D., et al., "Risk attribution and tobacco-related deaths," Am J 00/00/1993 Epidemiol 138:128-139 (1993) VOR-1 132 U.S: Department of Health and Human Services. Physical activity and health.. 00/00/1996 A Report of the Surgeon General: Centers for Disease Control and Prevention. pp. 143-150, 1996 LOR-11326 Wennberg, J.E., et al., "Hospital use and mortality among. Medicare ' 00/00/1989 beneficiaries in Boston and New Haven," New England Journal of Medicine 321:1168-1173 (1989) LOR-1 1327 Heart Answers 01/00/1984- 04/00/1984 LOR-11328 Pregnant Mothers: Please Don't Smoke 09/00/1998 LOR-1 1329 Draft Surgeon General Reports Obtained Pursuant to FOIA Request' LOR-11330 Pulmonary Scar Carcinoma: Report of Three Cases and Review of the 10/00/1995 Literature; Bok Y. Lee, M.D., et al., Military Medicine, Vol. 160, October 1995 LOR-11331 "Environmental Factors in Cancer of the Larynx, A Second Look," Ernest 00/00/1976 Wynder, et al., Cancer 58:1591-1601 (1976) LOR-1 1332 Life Skills Training; Evaluation Fact Sheet. Centers for Disease and: Prevention, National center for Chronic Disease Prevention and Health Promotion, Division of Adolescent and School Health (website) R-11333 LO "Scar Cancer of the Lung: Increase Over a 21 Year Period," Auerbach, M.D., 00/00/1979 __ et al.,'Cancer 43:636-642 (1979) LOR-1 1430 Bock, F.G., et al., "Carcinogenic Activity of Cigarette Smoke Condensate," 22 00/00/1959 J National Cancer Institute, 401 (1959) LOR-1 1431 Falk, H.L., et al., "Effects of Cigarette Smoke and its Constituents on Cilated 00/00/1959 Mucus-Secreting Epithelium," 23 J National Cancer Institute, 999 (1959) LOR-1 143 Bellett, S., et al., "Physiologic Basis for Prohibition Against Smoking," 00/00/1963 Coronary Heart Disease (1963) LOR-1 1433 Cederlof, R., et al., "The Interactions of Smoking, Environment, and Heredity - 00/00/1977 and their Implications for Disease Etiology," Acta Medica Scandinavia (Supp. 612) (1977) LOR-11434 Baric, J.M., et al., "Influence of Cigarette Pipe, and Cigar Smoking, Removabl 00/00/1982 Partial Dentures, and Age on Oral Leukoplakia," Oral Surgery, Vol. 54, No. 4, p.424(1982) LOR-1 1435 Grenhoff, J., et al., "Selective Stimulation of Limbic Dopamine Activity by 00/00/1988 Nicotine," 133 Act Physiological Scandinavica, 595-96 (1988) LOR-1 1436 Sellers, T.A., et al., "Evidence for Mendelian Inheritance in the Pathogenesis 00/00/1990 of Lung Cancer," Journal of the National Cancer Institute, Vol. 82, No. 15, pp. 1272-79 (1990) LOR-1 1437 Rangemark, C., et al., "Tobacco Use and Urinary Excretion of Thromboxane 00/00/1992 A2 and Prostacyclin Metabolites in Women Stratified by Age," 86 Circulation 1495 (1992) LOR-1 1438 Larson, P.S., et al., "Tobacco experimental and Clinical Studies," Supplement- 00/00/1975 III (1975) LOR-11439 Ayanian, J.A., Cleary, P.D., "Perceived risks of heart disease and cancer 0 0/0 011 99 9 among cigarette smokers," JAMA 281:1019-1021 (1999) LOR-11440 Beaglehole, R., "Conceptual frameworks for the investigation of mortality from 00/00/1995 major cardiovascular diseases," In: Lopez, A.D., Caselli, G., Valkonen, T., eds. Adult mortality in developed countries: From description to explanation. Oxford, England: Clarendon Press 37-56, 1995 ---, Page 50 of 79 98287972 1
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Exhibit Description: Document Name: Date: LOR-11548 U.S. Public Health Service. "Smoking and health: report of the Advisory 00/00/1964 Committee to the Surgeon General of the Public Health Service," Washington, DC: U.S. Department of Public Health, Education, and Welfare, 1964 (PHS publication no. 1103) LOR-11549 Weed, D., "On the use of causal criteria," International Journal of . 00/00/1997 Epidemiology 25:1137-1141 (1997) LOR-11552 Rosecrans, J.A., "Noncholinergic Mechanisms Involved in the Behavioral and 00/00/1987 Stimulus Effects of Nicotine, and the Relationships to the Process of Nicotine Dependence," in W. Martin, et al., Tobacco Smoking and Nicotine, pp. 125-29, Plenum Press (1987) LOR-11553 Knapp, P.H., et al., "Addictive Aspects of Heavy Smoking," American J. 00/00/1963 Psychiatry 119:966-972 (1963) LOR-11554 ° Seltzer, C.C., et al., "Differences in Pulmonary Function Related to Smoking' 00/00/1974 Habits and Race," American Review of Respiratory Disease 110(5):598-608- (1974) LOR-11555 Cross, K.R., et.al., "A Study of the Tracheobronchial Epithelium and Changes 00/00/1961 Related to Smoking," J. Iowa Med. Society 51:137 (1961) LOR-11556 Strong, J:P., et al., "On the Association of Cigarette Smoking with Coronary. 0010011969 and Aortic Atherosclerosis," J. Atheroscler. Res. 10:303-17 (1969) LOR-11557 , Leuchtenberger, C., et al., "A Correlated Histological, Cytological, and 00/00/1958 Cytochemical Study of the Tracheobronchial Tree and Lungs of Mice Exposed to Cig"arette Smoke," Cancer 11:490 (1958) LOR-11558 Heath, C.W., "Differences Between Smokers and Non-smokers;" AMA 00/00/1958 Archives of Internal Medicine 101:377-378 (1958) LOR-11559 Rama Sastry, B.V., "Smoking, Placental Function, n, and Fetal Growth;" Placental Toxicology, Chapter 3 LOR-11560 Larson and Silvette, "Tobacco and Tobacco Smoke: Experimental and 00/00/1971 Clinical. Studies," Supp. II; 1971 LOR-11561 Regan; T.J., et al., "Myocardial Response to Cigarette Smoking in Normal , 00/00/1961 Subjects and Patients with Coronary Disease," Circulation 23(3):365-369 (1961) LOR-11562 Regan, T.J., et al:; "Effect of Cigarette Smoking on Coronary Circulation and 00/00/1960 Cardiac Work in Patients with Arteriosclerotic Coronary Disease," Annals of New York Academy of Sciences 90:186-189 (1960) LOR-11563 Mulligan, J.J., et al., "Cigarette Smoke-Induced Depression in LCAT Activity," D0/00/1981 - Experimental and Molecular Pathology 35:25 (1981) LOR-11564 AMA-ERF Committee for Research on Tobacco and Health, "Tobacco and 00/00/1978 Health" (1978) LOR-11565 Letter from R.L. Wald to L. Loevinger regarding anti-trust implications of . 05/2011963 proposed Industry Code LOR-11566 Letter from L. Loevinger to R.L. Wald regarding anti-trust implications of 05/23/1963 proposed Industry Code LOR-1 1567 "Application of a Diffusion Denuder Method for the Investigation of the Effects of Smoke pH on Vapor-Phase Nicotine," Melissa Joseph and Emily Cochran LOR-11568 Memo from E.W. Cochran to M.A. Sudholt dated March 20, 2000, "Vapor 03/20/2000 Phase Nicotine Determinations for Reference Cigarette D65 REF/A and the DAP Treated Test Cigarette D67 TEST T/C," Project 470, H414 &OR-1 158 Letters. Laws Have Changed in Tobacco Industry 04/20/00 OR-11583 Tobacco Is Wacko If You're A Teen 00/0012000 Page 55 of 79 i 98287977
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Exhibit Description: Document Name: Date: LOR-11482 Tenkanen, L., et al., "Shift work, occupation and coronary heart disease over 6 00100/1997 years of follow-up in the Helsinki Heart Study," Scand J Work Environ Health 23:257-265 (1997) LOR-11483 Vartiainen, E., et al., "Do changes in cardiovascular risk factors explain the 00/00/1998 increasing socioeconomic difference in mortality from ischaemic heart disease in Finland?," J Epidemiol Community Health 52:416-419 (1998) LOR-11484 Wilhelmsen, L., et al., "The multifactor primary prevention trial in Goteborg, 00/00/1986 Sweden," Eur Heart J 7:279-288 (1986) LOR-11485 Williams, O.D., "Methodological issues in international comparisons," Int,J 00/00/1989 Epidemio{ 18(Suppl. 1):S166-S168 (1989) LOR-11486 Winkleby, M.A., et al., "Ethnic variation in cardiovascular disease risk factors 00/00/1999 among children and young adults," JAMA 281:1006-1013 (1999) LOR-1 1487 World Health Organization European Collaborative Group, "Multifactorial trial 00/00/1983 in the prevention of coronary heart disease: 3. Incidence and mortality' results," Eur Heart J 4:141-147 (1983) LOR-11488 World Health Organization Monica Project, "Ecological analysis of the " 00/00/1994 " association between mortality and major risk factors of cardiovascular disease," Int J Epidemiol 23:505-516 (1994) LOR-11510 Buck C. Popper's philosophy for epidemiologists. International Journal of 00/00/1975 Epidemiology 4:159-168 (1975) LOR-11511 Buck C. Popper's philosophy for epidemiologists (Letter). International Journal 00/00/1976 of Epidemiology 5:97-98 (1976) LOR-1 1512 Buck, C., et al., "The Challenge of Epidemiology. Issues and selected " 00/00/1988 readings," Washington, DC: Pan American Health Organization, 1988 LOR-1 1513 Burch, P.R.J., The Surgeon General's "epidemiologic criteria for causality:" A 00/00/1983 critique. Journal of Chronic Diseases-36:821-836 (1983)' LOR-11514 Burch, P.R.J., The Surgeon General's "epidemiologic criteria for causality." 00/0011984 Reply to Lilienfeld (Letter). Journal of Chronic Diseases 37:148-156 (1984) - LOR-11515 Creese, A., "Popper's philosophy for epidemiologists," (Letter) International 00/00/1975 Journal of Epidemiology 4:352-353 (1975) LOR-1 1516 Davies, A.M., Comments on "Popper's philosophy for epidemiologists" by- 00/00/1975 Carol Buck. International Journal of Epidemiology 4:169-170 (1975) LOR-11517 Goodman, S.N., et al., "Evidence and scientific research,".American Journal-o 00/00/1988' Public Health 78:1568-1574 (1988) LOR-11518_ Greenland, S., et al., "Identifiability, exchangeability, and epidemiological- 00/00/1986 confounding," International Journal of Epidemiology 15:413-419 (1986) ' LOR-11519 Greenland, S.; "Evolution,of Epidemiologic Ideas," Newton,M.A.: ' 00/00/1987 Epidemiology Resources, Inc., 1987 . LOR-11520 Greenland, S., et al., "Invariants and noninvariants in the concepfof 00/00/1988 interdependent effects," Scandinavian Journal of Work.Environment and Health 14:125-129 (1988) LOR-11521 Greenland, S., "Basis problems in interaction assessment," Environmental 00/00/1993 Health Perspectives 101(suppl 4):59-66 (1993) LOR-11522 Hill, A.B., "The environment and disease: Association or causation?," ' 00100/1965 Proceedings of the Royal Society of Medicine, 58(5):295-300 (1965) LOR-11523 Hintikka, J., et al., "Aspects of Inductive Logic," Amsterdam: North-Holland 00/0011966 Publishing Company, 1966 OR-11524 Jacobsen, M., "Against Popperized epidemiology," International Journal of . 00/00/1976 I Epidemiology 5:9-11 (1976) - --- Page 53 of 79 98287975
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Exhibit Description: Document Name: Date: LOR-29389 Present, D.H. and Banks, P.A., "Should Smoking Be Used in the Treatment of 00/00/1998 Ulcerative Colitis?" Inflammatory Bowel Diseases 4(4): 327, 1998 OR-29390 Lashner, B.A., Hanauer, S.B. and Silverstein, M.D., "Testing Nicotine Gum for 00/00/1990 Ulcerative Colitis Patients," Digestive Diseases and Sciences 35(7): 827-832, 1990 LOR-29391 Pullan, R.D., Rhodes, J., Ganesh, S., Mani, V., Morris, J.S., Williams, G.T., 0 0/0011 9 9 4 Newcombe, R.G., Russell, M.A.H., Feyerabend, C., Thomas, G.A.O. and Sawe, U., "Transdermal Nicotine forActive Ulcerative Colitis," The New England Journal of Medicine 330(12): 811-815, 1994 LOR-29392 Sandborn, W.J., Tremaine, W.J., Offord, K.P., Lawson, G., Petersen, B.T., 00/00/1997 Batts, K.P., Croghan, I.T., Dale, L., Schroeder, D.R. and Hurt, R.D., "Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis: A Randomized, Double-Blind, Placebo-Controlled Trial," Annals of Internal Medicine 126(5): 364-371, 1997 LOR-29393 Sandborn, W.J., "Nicotine Therapy for Ulcerative Colitis: A Review of 00/00/1999 Rationale, Mechanisms, Pharmacology, and Clinical Results," The American Journal of Gastroenterology 94(5): 1161-1171, 1999 LOR-29394 Sandborn, W.J., Tremaine, W.J., Leighton, J.A., Lawson, G.M., Zins, B.J.; " 00/00/1997 Compton, R.F., Mays, D.C., Lipsky, J.J., Batts, K.P., Offord, K.P., Hurt, R.D. and Green, J., "Nicotine Tartrate Liquid Enemas for Mildly to Moderately Active Left-sided Ulcerative Colitis Unresponsive to First-Line Therapy: A Pilot Study," Aliment. Pharmacol. Ther. 11: 663-671, 1997 LOR-29395 "Mortality After 16 years for Participant's Randomized to the Multiple Risk 00/00/1996 Factor Intervention Trial," Circulation 94(5): 946-951; 1996 LOR-29396 Postiglione, A., et. al., "New and Candidate Risk Factors for Coronary Heart 00/00/1994 Disease," Nutr Metab Cardiovasc Dis 4: 253-256; 1994 LOR-29397 WHO, "Cardiovascular Disease Risk Factors: New Areas for Research," WHO 00/00/1994 Technical Report Series # 841; 1994 Page 79 of 79 98288001
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Exhibit Description: Document Name: Date: LOR-11525 Koopman, J.S., "Causal models and sources of interaction," American Journal 00/00/1977 of Epidemiology 106:439-444 (1977) rOR-1 152 Koopman, J.S., "Interaction between discrete causes," American Journal of. 00I00/1981 Epidemiology 113:716-724 (1981) LOR-1 1527 Kupper, L.L., et al., "Interaction in epidemiological studies," American Journal 00/00/1978 of Epidemiology 106:447-453 (1978) LOR-1 1528 Kuller, L.H., "Invited Commentary: Circular Epidemiology," American Journal 00I00/1999 of Epidemiology 150:897-903 (1999) LOR-1 1529 Lakatos, I., "The Problem of Inductive Logic," Amsterdam: North-Holland 00/00/1968 Publishing Company, 1968 LOR-1 1530 Lakatos, I., et al., "Criticism and the Growth of Knowledge," Cambridge 00/00/1970 University Press, 1970 LOR-1 1531 Lilienfeld, A.M., "The Surgeon General's 'epidemiologic criteria for causality.' 00/00/1983 A criticism of Burch's critique," Journal of Chronic Diseases 36:837-845 (1983) ' LOR-1 1532 Magee, B., Philosophy and the real world. An introduction to Karl Popper. La 00/0011985 Salle, Illinois: Open Court 1985 LOR-1 1533 Miettinen, O.S., "Causal and preventive interdependence; elementary 00/00/1982 principles," Scandinavian Journal of Work, Environment and Health 8:159-168 " (1982) LOR-1 1534 Miller, D., "Popper Selections," Princeton;'NJ: Princeton University Press, 00/00/1985 1985 LOR-1 1535 Peto, R., "Cervical cancer and early sexual intercourse," (Letter) International 00/00/1976 Journal of Epidemiology 5:97 (1976) LOR-1 1536 Poole, C., "Beyond the confidence interval," American Journal of"Public Health 00/00/1987 77:195-198 (1987) OR-11537 Poole, C., "Confidence interval exclude nothing," American Journal of Public 00/00/1987 Health 77:492-493 (1987) LOR-1 1538 Poole, C., "Feelings and frequencies: Two kinds of probability in public health 00/00/1988 research," American Journal of Public Health 78:1531-1532 (1988) LOR-1 1539 Popper, K.R., "Objective Knowledge. An Evolutionary Approach," Oxford : 00/00/1979 University Press, 1979 . LOR-1 1540 Popper, K.R., "Realism and the Air of Science," London and New York: . 00/00/1985 Routledge, 1985 LOR-1 1541 Rothman, K.J., "Causes," American Journal of Epidemiology 104:587-592 00/00/1976 (1976) LOR-11542 Rothman, K.J., "Causal Inference," Chestnut Hill, MA: Epidemiology 00/0011988 Resources Inc., 1988 LOR-11543 Siemiatycki, J., et al., "Biological models and statistical interactions: an ":. 00/00/1981 example from multistage carcinogenesis," International Journal of Epidemiology 10:383-387 (1981) LOR-1 1544 Smith, A., Comments on "Popper's philosophy for epidemiologists" by Carol 00/00/1975 Buck, Internation Journal of Epidemiology 4:171-172 (1975) LOR-11545 Susser, M., "Causal Thinking in the Health Sciences. Concepts and 00/00/1973 Strategies of Epidemiology," New York: Oxford University Press, 1973 LOR-1 1546 Susser, M., Epidemiology today: 'A thought-tormented world'," International 0 0/0 011 9 8 9 Journal of Epidemiology 18:481-488 (1989) LOR-11547 Thompson, W.D., "Effect modification and the limits of biological inference 00/00/1991 from epidemiological data," Journal of Clinical Epidemiology 44:221-232 (1991) Page 54 of 79 - '~ 98287976
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Exhibit Description: Document Name: Date: LOR-29005 Armitage, A.K., et al., "Absorption of Nicotine by Man during Cigar Smoking," 0 010 0/1 9 7 7 Proceedings of the B.P.S., 5th-7th January, 1977, British Journal of Pharmacology, 59(3):493 (1977) LOR-29006 Armitage, A.K., "Some Recent Observations Relating to the,Absorption of. 00/00/1973 Nicotine from Tobacco Smoke," In: Smoking Behavior: Motives and Incentives, William L. Dunn (ed.), 1973, Chapter 6, pp. 83-91 LOR-29007 Artho, A.J., Grob, K., "Nicotine Absorption from CigaretteSmoke: Excerpts 0 010 0/1 9 64 Presented at the 17th Tobacco Chemists' Research Conference, Montreal, September, 1963," Z Preventivemed, 9:14-25 (1964) LOR-29008 Ashton, H. and Stepney, R., "Importance of Nicotine," In: Smoking; 00/00/1982 Psychology and Pharmacology. Tavistock Publications, New York, 1982, Chapter 2, pp. 18-41 LOR-29009 ` Baker, Richard R., "Smoke Chemistry," CORESTA Monograph on Tobacco, 00/00/1995 1995 LOR-29010 Ballantyne, Marrs and Syversen, General and Applied Toxicology, 2nd edition, 00/00/1999 McMillan Press (1999) LOR-29011 Baumberger, J.P., "The Nicotine Content of Tobacco Smoke," J Pharm Exp 00/00/1923 Ther 21:35-46 (1923) LOR-29012 Benedict, R.C. and Lakritz, L., "Simultaneous Determination of pH and Redox 00/00/1975 Potential: Application to Cigarette Smoke," Tobacco Science 19:1,1 (1975) LOR-29013 Benowitz, N.L., et al., "Pharmacokinetics, Metabolism, and _ 00/00/1990 Pharmacodynamics of Nicotine," In: Nicotine Psychopharmacology, Molecular, Cellular, and Behavioural Aspects. S. Wonnacott, M.A.J. Russell and I.P. Stolerman (eds.). Oxford University Press, New York, 1990, pp. 112- 157 OR-29014 Benowitz, N.L., "Pharmacologic Aspects of Cigarette Smoking and Nicotine 00/00/1988 Addiction," The New England Journal of Medicine 319(20):1319-1330 (1988) - . LOR-29015 Benowitz, N.L., "Clinical Pharmacology of Inhaled Drugs of Abuse: :. 00/00/1990 Implications in Understanding.Nicotine Dependence," In: Research Findings on Smoking of Abused Substances. NIDA Research Monograph, DHHS Pub. =- No. (ADM) 90-1690, pp. 12-29 (1990) LOR-29016 Brunnemann, K.D. and Hoffmann, D., "The pH of Tobacco Smoke," Fd. 00/00/1974 Cosmet Toxicol 12:115-124 (1974) . LOR-29017 Burch, S.G., et al., "Effect of pH on Nicotine Absorption and Side Effects 00/00/1993 Produced by Aerosolized Nicotine," Journal of Aerosol Medicine 6(1):45-52 (1993) LOR-29018 . Cohen, A.J. and Roe, F.J.C., "Monograph on the pharmacology and - 00/00/1981 Toxicology of Nicotine," Tobacco Advisory Council, Occasional Paper 4;• London (1981) LOR-29019 Conroe, J., Physiology of Respiration. Year Book Publisher (1965) ' 00/00/1965 LOR-29020 Darby, T.D., et al., "Cigarette Smoking Pharmacokinetics and its Relationship 00/00/1984 to Smoking Behavior," Clinical Pharmacokinetics 9:435-449 (1984) LOR-29021 Darkis, R.R. and Hackney, E.J., "Cigarette Tobaccos: Chemical Clianges 02/00/1952 That Occur During Processing,"lndustrial and Engineering Chemistry, .: 44(2):284-291, February 1952 LOR-29022 Diagnostic and Statistical Manual of Mental Disorder. DSM-IV, APA (1996) 00/00/1996 LOR-29023 Doull, J., Frawley, J.P., George, W., et al., "A Safety Assessment of . 00/00/1994 Ingredients Added to Tobacco in the Manufacture of Cigarettes," 1994; Submitted to Covington & Burling, Bates #2023900830-924 Page 57 of 79 98287979
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Exhibit Description: Document Name: Date: LOR-29160 Baby Boomers and Cardiovascular Diseases: Biostatistical Fact Sheets. 00/0012000 American Heart Association, 2000, www.americanheart.org OR-29161 Coronary Heart Disease and Angina Pectoris. American Heart Association, 00/0 011 99 9 1999, www.americanheart.org LOR-29162 Risk Factors. American Heart Association, 1999, www.americanheart.org 00/00/1999 LOR-29163 Shopland, D. and Burns, D., "Chapter 5: Age and the Exposure-Response 00/00/1997 Relationships Between Cigarette Smoking and Premature Death in Cancer Prevention Study II." Monograph 8: Changes in Cigarette-Related Disease Risks and Their Implication of Prevention and Conrol, 1997 LOR-29164 Freedman, D.A. and Navidi, W.C., "Ex-Smokers and the Multistage Model for 00/00/1990 Lung Cancer." Epidemiology 1; 21-29, 1990 LOR-29165 Reducing the health consequences of smoking, Surgeon General's Report 00/00/1989 1989 LOR-29166 The health benefits of smoking cessation, Report of the Surgeon General 00/000/1990 1990 LOR-29167 WHO MONICA Project: Objectives and Design. Inter J Epid 1989; 18:29 00/00/1989 LOR-29168 Ecological analysis of the association between mortality and major risk factors. 00/0011994 Inter J Epid 1994; 23:505 LOR-29169 Press release (Aug. 24, 1998) WHO MONICA Project 0 8/2411 9 9 8 LOR-29170 Did MONICA really say that? (Editorial) Brit Med J 1998; 317:1023 00/0011998 LOR-29171 The health consequences of smoking: A report of the Surgeon General 1982 00/00/1982 LOR-29172 Highlights of the Varese Conferences. Lung cancer frontiers, March 1999 03/00/1999 LOR-29173 Smoking and Health. Report of Advisory Committee.to the Surgeon General 00/00/1964 1964 OR-29174 The Heart, Arteries and Veins XIIIth Edition. Editors Robert C. Schlant, et al. OR-29175 Stokes, et al. The relative importance of select risk factors for various 0 0/0 011 987 manifestations of cardiovascular disease. Circ 1987; 75:65 LOR-29176 Kaplan GA and Keil. Socioeconomic factors and cardiovascular disease. A 00/00/1993 review of the literature: Circ 1993; 88:1973 LOR-29177 WHO Technical Report. Cardiovascular Disease Risk Factors: New Areas for 00/00/1994 Research. Geneva 1994 LOR-29178 The Canadian Guide to Clinical Preventive Health Care. The Canadian Task 00/00/1998 Force of Periodic Health Examination 1998 LOR-29179 IVth World Conference on Lung Cancer. Chest 1986; 89 _ 00/0071986 LOR-29180 Mulshine, et al. Prevention-oriented applications of biomarkers. Lung Cancer 06/00/1994 June 1994 LOR-29181 Woolf SH, et al. Health promotion and disease prevention in clinical practice,' 00/00/1996 - (eds. Williams and Wilkins) 1996 LOR-29182 Biomarkers: Medical and workplace applications. 1998. Joseph Henry Press 00/00/1998 LOR-29183 Obstructive lung diseases, Part I. Dosman JA and Cockroff DW eds. Medical 0010071996 - Clinics of North America 1996; 80 LOR-29184 Fletcher GF, et al. Exercise, standards. A statement for health professionals 00/00/1990 from the American Heart Association. Circ 1990; 82:2286 LOR-29185 Kannel WB. Silent Myocardial Ischemia and Infarction: Insights from the 11/00/1986 Framingham Study, Cardiology clinics, Vol. 4, No. 4,-November 1986 LOR-29186 Welch HG, et al. Are Increasing 5-Year Survival Rates Evidence of Success 00/00/2000 Against Cancer? JAMA 2000; 283(22): 2975-2978 OR-29187 Patz EF, et al. Correlation of Tumor Size and Survival in Patients With Stage 00/00/2000 IA Non-Small Cell Lung Cancer. Chest 2000; 117: 1568-1571 Page 65 of 79 98287987
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Exhibit Description: Document Name: Date: LOR-29061 Rickert, W.S., "Partial Characterization of 10'Common' Brands of American 01/30/1997 Cigarettes," Project Report Prepared for: Massachusetts Department of Public Health, Labstat, Inc., Kitchener, Ontario, Canada (January 30, 1997) LOR-29062 Rickert, W.S., "Ammonia Cigarette Study: Final Report," Prepared for Phillip 03/08/1999 Morris, U.S.A., Labstat International, Inc., Kitchner, Ontario, Canada (March 8, 1999) LOR-29063 Rose, J.E., et al., "Arterial Nicotine Kinetics During Cigarette Smoking and 00/00/1999 Intravenous Nicotine Administration: Implications forAddiction," Drug and Alcohol Dependence 56(2):99-107 (1999) LOR-29064 Rowell, P.P., Caerr, L.A., "Historical Review of Nicotine's Actions," Departmen 02/19/1997 of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky (February 19, 1997) LOR-29065 Russell, M.A.H., "Nicotine Intake and its Regulation," Journal of 00/00/1980 Psychosomatic Research 24(5):253-264 (1980) LOR-29066 Russell, M.A.H., et al., "Nicotine Replacement in Smoking Cessation," JAMA 06/19/1987 257(23):3262-3265 (June 19, 1987) LOR-29067 Russell, M.A.H. and Fayerabend, C., "Cigarette Smoking: A Dependence on 00/00/1978 High-Nicotine Boli," Drug Metabolism.Reviews 8(1):29-57 (1978) LOR-29068 Russell, M.A.H., "The Case for Medium-Nicotine, Low-Tar, Low-Carbon 00/00/1980 Monoxide Cigarettes," Banbury Report 3, G.B. Gori and F.G. Bock (eds.), Col Spring Harbor Laboratory, pp. 297-310 (1980) LOR-29069 Schievelbein, H., "Nicotine, Resorption and Fate," In: Nicotine and the 00/00/1984 Tobacco Smoking Habit, D.J.K. Balfour (ed.), International Encyclopedia of Pharmacology and Therapeutics (section 114). Chapter 1, Pergamon Press. Oxford. 114:1-15 (1984) OR-29070 "Absorption of Nicotine Through the Oral Mucosa: I: - Schievelbein H. et al. 00/00/1973 , , , Measurement of Nicotine Concentration in the Blood After Application of Nicotine and Total Particulate Matter," Agents and Actions 3(4):254-264 (1973) LOR-29071 Schievelbein, H., et al., "Cardiovascular Actions of Nicotine and Smoking," J 00/00/1972 National Cancer Inst 48:1785-1789 (1972) LOR-29072 Schievelbein, H., "Nicotine, Resorption and Fate," Pharmacology and . 00/00/1982 Therapeutics 18(2):233-247 LOR-29073 Schievelbein, H.; et al., "Absorption of Nicotine Through the.Oral.Mucosa. II. 00/00/1973 Measurement of Blood Pressure After Application of Nicotine and Total Particulate Matter," Agents and Actions, Vol 3/4 (1973) LOR-29074 Seeman, J.l., et al., "The Form of Nicotine in Tobacco. Thermal Transfer of 00/00/1999 Nicotine and Nicotine Acid Salts to Nicotine in the Gas Phase," J Agric Food Chem 47:5133-5145 (1999) LOR-29075 Sensabaugh, Jr., A.J., et al., "A New Technique for Determining the pH of 00/00/1967 Whole Tobacco Smoke," Tobacco Science, Vol. XI (1967) LOR-29076 Shmuk, A., "The Taste Quality and Chemical Composition of Tobacco," In: 00/00/1953 The Chemistry and Technology of Tobacco, Vol. III, Gavrilov (ed.). Originally published Moscow (1953) LOR-29077 Slade, J., "Are Tobacco Products Drugs? Evidence from US Tobacco," 00/00/1995 Tobacco Control 4(1):1-2 (1995) LOR-29078 Slade, J., "Nicotine Delivery Devices," In: Nicotine Addiction: Principles and 00/00/1993 Management. C.T. Orleans and J. Slade (eds). Oxford University Press, New York, pp. 3-23 (1993) - - Page 60 of 79 98287982
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Exhibit Description: Document Name: Date: LOR-29188 Acheson, E.D., M.J. Gardner, P.D. Winter and C. Bennett. "Cancer in a 00/0011984 Factory Using Amosite Asbestos." International Journal of Epidemiology 13:3- 10, 1984 LOR-29189 American Thoracic Society. "The Diagnosing of Nonmalignant Diseases 00/00/1986 Related to Asbestos." Am. Rev. Respir. Dis. 134:336-368, 1986 LOR-29190 L. Garfinkel, and E.C. Hammond. "Relation of Smoking and Auerbach 0. 00/00/1974 , , Age to Findings in Lung Parenchyma: A Microscopic Study." Chest 65(1):29- 35, 1974 LOR-29191 Auerbach, O., A.P. Stout, E.C. Hammond, and L. Garfinkel.. "Smoking Habits 00/00/1963 and Age in Relation to Pulmonary Changes. Rupture of Alveolar Septums, Fibrosis and Thickening of Walls of Small Arteries and Arterioles." The New England Journal of Medicine 269(20):1045-1054, 1963 LOR-29192 Barnhart, S., M. Thornquist, G.S. Omenn, G. Goodman, P. Feigl, and L. 00/00/1990 Rosenstock.- "The Degree of Roentgenographic Parenchymal Opacities Attributable to Smoking among Asbestos-exposed Subjects." American Review of Respiratory Disease 141:1102-1106, 1990 LOR-29193 Barrett, J.C. "Cellular and Molecular Mechanisms of Asbestos 00/00/1994 Carcinogenicity: Implications for Biopersistence." Environmental Health Perspectives 102(Suppl. 5): 19-23, 1994 LOR-29194" Berman, D.W:, K.S. Crump, E.J. Chatfield, J.M.G. Davis, and A.D. Jones. 0010011995 Shapes and Mineralogy of Asbestos Structures that Induce Lung "The Sizes , Tumors or Mesothelioma in AF/HAN.Rats Following Inhalation." Risk Analysis 15(2):181-195, 1995 LOR-29195 Berry, G., M.L. Newhouse, and P. Antonis. "Combined Effect of Asbestos and 00/00/1985 Smoking on Mortality from Lung Cancer and Mesothelioma in Factory Workers." British Journal of Industrial Medicine 42:12-18, 1985 LOR-29196 Berry, G., J.C. Gilson, S. Holmes, H.C. Lewinsohn, and S.A. Roach. 00/00/1979 "Asbestosis: A Study of Dose-Response Relationships in an Asbestos Textile Factory." British Journal of Industrial Medicine 36:98-112, 1979 LOR-29197 Berry, G., M.L. Newhouse, M. Turok. "Combined Effect of Asbestos Exposure 09/02/1972 and Smoking on Mortality from Lung Cancer in Factory Workers." The Lancet, pp. 476-479, September 2, 1972 LOR-29198 Berube, K.A., T.R. Quinlan, G. Moulton; D. Hemenway, P. O'Shaughnessy, P. 00/00/1996 Vacek, B.T. Mossman. "Comparative Proliferative and Histopathologic Changes in Rat Lungs After Inhalation of Chrysotile or Crocidolite Asbestos." Toxicology and Applied Pharmacology 137:67-74, 1996 , LOR-29199 Blanc, P. "Cigarette Smoking, Asbestos, and Parenchymal Opacities 00/0071991 ' Revisited." Annals of the New York Academy of Sciences 643:133-141,.1991 LOR-29200 Blanc, P.D:, J:A: Golden, G. Gamsu, D. Aberle, and W.M.-Gold. -"Asbestos 0 0/0 011 9 8 8 Exposure-Cigarette Smoking Interactions among Shipyard Workers." Journal of the American Medical Association 259(3):370-373, 1988 LOR-29201 Blot; W.J., J.M. Harrington, A. Toledo, R. Hoover, C.W. Heath, and J.F. 00/00/1978 Fraumeni. "Lung Cancer After Employment in Shipyards During World War II." The New England Journal of Medicine 299(12):620-624, 1978 LOR-29202 Blot; W.J., L.E. Morris, R. Stroube, I. Tagnon, and J.F. Fraumeni, Jr. "Lung 00100/1980 and Laryngeal Cancers in Relation to Shipyard Employment in Coastal Virginia:" Journal of the National Cancer Institute 65(3):571-575, 1980 98287988 Page 66 of 79
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Exhibit Description: Document Name: Date: LOR-29099 Gealy, R., Zhang, L., et al. Comparison of mutations in the p53 and k-ras 00/00/1999 genes in lung carcinomas from smoking and nonsmoking women. Cane. Epidemiol. Biorri. Prev. 8:297-302. 1999 LOR-29100 Harris C.C., et al. Histogenesis of squamous metaplasia in the hamster ' 00/00/1972 tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-Ferric oxide.J. Natl. Canc. Inst 48:743-61. 1972 LOR-29101 Harris,R.J.C., et al. The incidence of lung tumors in C57BL mice exposed to 0 010 0/1 9 74 cigarette smoke:air mixtures for prolonged periods. Int. J. Cancer 14:130-6. 1974 - LOR-29102 Heckman, C.A. and Dalbey, W.E. Pathogenesis of lesions induced in rat lung 00100/1982 by chronic tobacco smoke inhalation. J. Natl. Canc. Inst. 69:117-29. 1982 LOR-29103 Heckman, C.A., and Lehman, G.L. Ultrastructure and distribution of 00/00/1965 intracellular spicules in rat lung following chronic tobacco smoke exposure. J. Natl. Cane. Inst. 74:647-57. 1985 LOR-29104 . Henry, C.J., and Kouri, R.E. Chronic inhalation studies in mice. II... Effects of 00/00/1986 long term-exposure to 2R1 cigarette smoke on (C57BL/Cum X C3H/AnfCum)F1 mice,J. Natl. Cane. Inst. 77:203-12. 1986 LOR-29105 Hung, J., et al. Allele-specific chromosome 3p deletions occur at an early, 00/00/1995 stage in the pathogenesis of lung carcinoma. J. Am. Med. Assoc. 273:1908. 1995 LOR-29106 Husgafvel-Pursiainen, K., et al. p53 mutations and exposure to environmental 00/00/2000 tobacco smoke in a multicenter study on lung cancer. Canc. Res. 60:2906-11. 2000 LOR-29107 14uamasa; T. et al. Prognostic implication of human papillomavirus infection in 00/00/2000 squamous cell carcinoma of the lung. Pathol. Res. Prac. 196:209-18. 2000 OR-29108 Joiakim, A.P., and Chopra, D.P. Retinoic acid and calcium regulation of p53, 00/00/1993 TGF-f3, and TGF-a gene expression and growth of Adenovirus 12-SV40 transformed human tracheal gland epithelial cells. Am. J. Respir. Cell Mol. Biol. 8:408-16. 1993 LOR-29109 Leuchtenberger, C., and Leuchtenberger, R. Differential response'of Snell's 00/00/1974: and C57 black mice to chronic inhalation of cigarette smoke. Oncology ' 29:122-38. 1974 LOR-29110 London, S.J., et al. Isothiocyanates, glutathione S-transferase M1 and TI 00/00/2000: polymorphisms, and lung cancer risk: a prospective study of men in Shanghai, China. Lancet (London) 356:724-9. 2000 LOR-29111 Mao, L: Clonal genetic alterations in the lungs of current and former smokers. 00/00/1997 J. Natl. Canc. Inst. 89:857-62. 1997 LOR-29112 Matulionis, D,H. Chronic cigarette smoke inhalation and aging in.mice: 1. < 00/00/1984 Morphologic and functional lung abnormalities. Exp. Lung Res. 7:237-256. . 1984 LOR-29113 Perwez-Hussain, S., and Harris, C.C. Molecular epidemiology and 00/00/2000 carcinogenesis: endogenous and exogenous carcinogens. Mut. Res. 462:311-22. 2000 LOR-29114 Rhim, J.S., et al. Neoplastic conversion of human keratinocytes by adenoviru 00I00/1986 12-SV4G virus and chemical carcinogens: Science 232:385-8. 1986 LOR-29115 Rhim, J.S., et al. Stepwise immortalization and transformation of adult human 00/00/1994 prostate epithelial cells by a combination of HPV-18 and V-Ki-ras. Proc. Natl. Acad. Sci. 91:11874-8. 1994 98287984 ' Page 62 of 79.
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Exhibit Description: Document Name: Date: LOR-29079 Stedman, R.L., et al., "Composition Studies on Tobacco XXXIII Changes in 06/00/1969 Smoke Composition and Filtration by Artificial Alteration of Smoke pH: Pyridine and Nicotine," Beitrage Tabakforsch 5(1):13-17 (June 1969) LOR-29080 Report of the Surgeon General of the United States (1983) 00I00/1983 LOR-29081 Report of the Surgeon General of the United States (1979) Chapter 13 and 14 00/00/1979 LOR-29082 Travell, J., "Absorption of Nicotine from Various Sites," Annals of the New Yor 00/00/1960 Academy of Sciences 13-30 (1960) LOR-29083 Vicery, H.B. and Pucher, G.W., "The Determination of Free Nicotine in 00/00/1929 Tobacco: The Apparent Dissociation Constants of Nicotine," J Biol Chem . 84:233, 241 (1929) LOR-29084 Bartsch, H., et al. Genetic polymorphism of CYP genes, alone or in - 00/00/2000 combination, as a risk modifier of tobacco-related cancers. Canc. Epi. Biom. Prev. 9:3-28. 2000 LOR-29085- Bennett, W.P. et al. Molecular epidemiology of human cancerrisk: Gene- 00100/1999 environment interactions and p53 mutation spectrum in human lung cancer. J. Pathol. 187:8-18. 1999 LOR-29086 Bernfeld, P. et al. Cigarette smoke inhalation studies in inbred Syrian Golden 00/00/1979 Hamsters. J. NatI. Canc. Inst. 63:675-98: 1979 LOR-29087 Bjelke, E. Dietary vitamin A and human lung cancer. Int. J. Cancer. 15:561- 00100/1975 5. 1975 LOR-29088 Chopra, D.P. Retinoid reversal of squamous metaplasia in organ cultures of 00/00/1983 trachea derived from hamsters fed vitamin A-deficient diet. Eur. J. Canc., Clin. Oncol. 19:847-57. 1983 LOR-29089 Chopra, D.P., and Wilkoff, L.J. Activity of retinoids against benzo(a)pyrene 00/00/1979 induced hyperplasia of mouse prostate organ cultures. Eur. J..Canc. 15:1417- 23. 1979 LOR-29090 Chopra, D.P., and Wilkoff, L.J. Reversal by vitamin A analogs (retinoids) of 00/00/1977 hyperplasia induced by N-methyl-N-nitro-N-nitrosoguanidine in mouse prostate organ culture. J. Natl. Canc. Inst. 58:923-30. 1977 LOR-29091 Chopra, D.P., et al. Effects of vitamin A on growth and differentiation in . 00/00/1989 human tracheobronchial epithelial cell cultures in serum-free medium. J. Cell Sci. 93:133-42. 1989 LOR-29092 Chopra, D.P, and C,ooney, R.A. Effect of vitamin A deficiency on morphology 0 010 0/1 99 0 and cell proliferation of hamster trachea. Cell Tissue Kinet. 23:575-85. 1990 LOR-29093 Coggins, C.R.E., et al. Chronic inhalation study in rats, using cigarettes 00/00/1982 . containing different amounts of Cytrel tobacco supplement. Toxicology 22:287-96. 1982 LOR-29094 Coggins, C.R.E. A review of chronic inhalation studies with mainstream ' 00/00/1998 cigarette smoke in rats and mice. Toxicologic Pathology 26:307-14. 1998 LOR-29095 Dalbey, W.E. Chronic Inhalation of cigarette smoke by F344 rats. J. NatL:: 00/00/1980 Ca n c. I nst. 64:383-90. 1980 LOR-29096 Davis, B.R., et al. Response of rat lung to inhaled tobacco smoke with or 00100/1975 without prior exposure to 3,4-benzpyrene (BP) given by intratracheal installation. Br. J. Canc. 31:469-84. 1975 . LOR-29097 Dontenwill, W., et al. Investigations on the effects of chronic cigarette-smoke 00/00/1973 inhalation in Syrian Golden Hamsters. J. Natl. Canc. Inst. 51:1781-1832. 197 LOR-29098 Gao, H.-G., et al. Distribution of p53 and k-ras mutations in-human lung 00100/1997 cancer tissues. Carcinogenesis 18:473-8. 1997 98287983 Page 61 of 79
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Exhibit Description: Document Name: Date: LOR-29136 Law, M. and Tang, J.L., "An Analysis of the Effectiveness of Interventions 00/00/1995 Intended to Help People Stop Smoking." Arch Intern Med 155: 1933-41, 1995 LOR-29137 "54: Counseling to Prevent Tobacco Use." Report of the US Preventive 00/00/1996 Services Task Force, Second Edition, 597-609, 1996 LOR-29138 Lung Cancer: Prevention and Risk Factors. The Lung Cancer Resource,. 00/00/2000 2000; www.cancer.org LOR-29139 Lung Cancer: Treatment. The Lung Cancer Resource, 2000, www.cancer.org 00/00/2000 LOR-29140 "Pretreatment Evaluation of Non-Small CeII,Lung Cancer: Official Statement 00/00/1997 of the American Thoracic." Am J Respir Crit Care Med 156: 320-32, 1997 LOR-29141 Dalrymple, T., "War Against Cancer Won't Be Won Soon." Wall Street 06/12/2000 Journal, Jun. 12, 2000 LOR-29142 Laird, A.K., "Dynamics of Tumour Growth: Comparison of Growth Rates and 00/00/1965 Extrapolation of Growth Curve to One Cell," 1965 LOR-29143 Inoue, K. and Sato, M., "Prognostic Assessment of 1310 Patients with Non- 00/00/1998 Small Cell Lung Cancer Who Underwent Complete Resection From 1980 to 1993." J Thorac Cardiovasc Surg 116: 407-11, 1998 LOR-29144 Nesbitt, J.C. and Putnam, J., "Survival in Early Stage Non-Small Cell Lung." 00/00/1995 Ann Thorac Surg 60: 466-, 1995 LOR-29145 Collins, V.P. and Loeffler, K.R., "Observations on Growth Rates of Human 00/00/1956 Tumors." Am J Roentgenol Rad Ther 76:988-, 1956 LOR-29146 Landis, S. H. and Murray, T., "Cancer Statistics 1998." Ca-A Cancer Journal 00/00/1998 for Clinicians. The American Cancer Society 48(1): 6-, 1998 LOR-29147 Mountain, Clifton F., "Revisions in the International System for Staging Lung 00/00/1997 Cancer." Chest 111: 171, 1997 LOR-29148 Nathan, M.H. and Collins, V.P., "Differentiation of Benign and Malignant 00/00/1962 Pulmonary Nodules by Growth Rate." Radiology 79: 221-, 1962 LOR-29149 Shah, R. and S.S., "Results of Surgical Treatment of Stage I and Stage II:Lun 00/00/1996 Cancer," J Cardiovasc Surg 37: 169-, 1996 LOR-29150 Staging: Evaluation of Extent of Disease. Abeloff: Clinical- Oncology 2nd, 200 00100/2000 LOR-29151 _ MacDonald, L.A. and Sackett, D.L., "Labelling in Hypertension:.A Review of ;? 00/00/1984 the Behavioral and Psychological Consequences." J Chron Dis 37(12): 933- 42, 1984 LOR-29152 Bailar, J. and Smith, E., "Progress Against Cancer?" New England`Journal of: 00/00/1986 Medicine 6314: 122, 1986 LOR-29153 Gazdar, A.F. and Minna, J.D., "Cigarettes, Sex, and Lung Adenocarcinoma.". 00/00/1997 Journal of the National Cancer Institute 89(21): 1, 1997 LOR-29154 Thun, M.J. and Lally, C:A., "Cigarette Smoking and Changes in_the~ ' 00/00/1997 Histopathology of Lung Cancer," Journal of the National Cancer Institute 89(21): 1, 1997 LOR-29155 Wynder, E.L. and Goodman, M.T., "Smoking and Lung Cancer: Some 00/00/1983 Unresolved Issues." Epidemiologic Reviews, Vol. 5, p. 17, 1983 LOR-29156 Roscoe, R.J. and Steenland, K., "Lung Cancer Mortality Among Nonsmoking 0 0/0 011 9 8 9 Uranium Miners Exposed to Radon Daughters." JAMA 262(5): 629-33, 1989. LOR-29157 McFarlane, K. and Feinstein, The 'Epidemiologic Necropsy'. JAMA 258(3): 00100/1987 33, 1987 LOR-29158 Cardiovascular Disease Statistics. American.Heart Association, 2000, 00/00/2000 www.americanheart. org OR-29159 Leading Causes of Death - 1997 Cardiovascular Diseases: Biostatistical Fact 00/00/2000 Sheets. American Heart Association, 2000, www.americanheart.org - - -- Page 64 of 79 98287986
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Exhibit Description: Document Name: Date: LOR-29116 Rusin, M., et al. Molecular epidemiological study of nonsmall cell lung cancer 00/00/1999 from an environmentally polluted region of Poland. Br. J. Canc. 80:1445-52. 1999 LOR-29117 Saffiotti, U. Experimental respiratory tract carcinogenesis. Prog. Exp. Tumor 00/00/1969 Res. 11:302-33. 1969 LOR-29118 Sporn, M.B. Chemoprevention of cancer with retinoids. Fed. Proc. 38:2528- 00/00/1979 34.1979 LOR-29119 Sporn, M.B., and Roberts, A.B. Role of retinoids in differentiation and 00/00/1983 carcinogenesis. Canc. Res. 43:3034-40. 1983 LOR-29120 Sporn, M.B., et al. Mechanism of action of retinoids. J. Am. Acad. Dermatol. 00/00/1986 15:756-64. 1986 LOR-29121 Takagi, Y., Kuroishi, T.; et al. p53 mutations in non-small cell1ung cancers . 00/00/1998 occurring in individuals without a past history of active smoking. Br. J. Canc. 77:1568-72. 1998 LOR-29122 Wille, J.J., and Chopra, D.P. Reversal by retinoids of keratinization induced 00/00/1988 . by benzo(a)pyrene in normal hamster tracheal explants: comparison with the assay involving organ culture of tracheas from vitamin A-deficient hamster. Canc. Left. 40:235-46. 1988 LOR-29123 Wistuba, I.I. et al. Sequential molecular abnormalities are involved in the 00/00/1999 multistage development of squamous cell lung carcinoma. Oncogene 18:643- 50: 1999 LOR-29124 Wu X., et al. Cytochrome P4502E1 Dral polymorphisms in lung cancer in 00/00/1998 minority populations. Canc. Epi. Biom. Prev. 7:13-8. 1998 LOR-29125 Yoakum, G.H., et al. Transformation of human bronchial epithelial cells 00/00/1985 transfected by Harvey ras oncogene. Science 227:1174-9. 1985 OR-29126 "Age-Adjusted Prevalence of Current Cigarette Smoking Among Adults by '; Sex, 1978-1995. Cancer Incidence Rates. Cancer Death Rates." NCI Relate Charts and Graphs on Cancer Status, http://rex.nci.nih.gov/massm LOR-29127 "Healthy People 2010-Conference Edition: 3: Cancer." Healthy People 2010- Conference Edition, www.health.gov/healthypeople/Doc LOR-29128 Smith, G., "Epidemiology of Lung Cancer." Radiologic Clinics of North 38(3), 00/00/2000 2000 LOR-29129 "Cigarette Smoking and Health: Official Statement of the American Thoracic ; 00/00/1995 Society." Am J Respir Crit Care Med 153: 861-65, 1995 LOR-29130 _ Healthy People. 2010-Conference Edition: 27: Tobacco Use. Healthy People 2010-Conference Edition, www.health.gov/healthypeople/Doc LOR-29131 _ "Receipt of Advice to Quit Smoking in Medicare Managed Care - United, - 00/00/2000 States, 1998." MMWR 49(35): .797-801, 2000 . LOR-29132 Cancer Facts: Lung Cancer and Cigarette Smoking Facts. National Cancer 00/00/1996 Institute1996, http://cis.nci.nih LOR-29133 Cancer Net: Questions and Answers About Cigarette Smoking and Cancer: 00/00/1999 Cancer Facts.Cancer Net. National Cancer Institute,1999, http://cancernet LOR-29134 Wei, Q. and Cheng, L. "Repair of Tobacco Carcinogen-Induced DNA Adducts 00/00/2000 and Lung Cancer Risk: a Molecular Epidemiologic Study." Journal of the National Cancer Institute92(21): 1764-72, 2000 LOR-29135 Fiore, M. and Piasecki, T.; "Chapter G1: Cigarette Smoking: The Leading - 00/00/1998 Preventable Cause of Pulmonary Disease," Bone: Pulmonary & Critical Care Medicine, 1998 98287985 Page 63 of 79
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Exhibit Description: Document Name: Date: LOR-29024 Doull, J., Frawley, J.P., George, W., et al., "A Safety Assessment of 00/00/1998 Ingredients Added to Tobacco in the Manufacture of Cigarettes," 1998, Submitted to Covington & Burling, Bates #2063665800-815 LOR-29025 Elson, L.A., et al., "The Sugar Content and the pH of the Smoke of Cigarette, 00/00/1972 Cigar and Pipe Tobaccos in Relation to Lung Cancer," International Journal of Cancer, 9:666-675 (1972) LOR-29026 Elson, L.A., et al., "The Sugar Content and the pH of the Smoke in Relation to 00/00/1972 Lung Cancer Risks of Cigarette Smoking," Journal National Cancer Institute, 48(6):1885-1890 (1972) LOR-29027 Goodman and Gillman. The Pharmacological Basis of Therapeutics. 9th 00/00/1996, Edition. McGraw-Hill (1996) LOR-29028 Gori, G., "Low-Risk Cigarettes: A Prescription," Science 194:1243-1246, 1243 12/17/1976 (Dec. 17, 1976) LOR_ -29029 Gori, G.B., Benowitz, N.L., et al., "Mouth Versus Deep Airways Absorption of 00/00/1986 Nicotine in Cigarette Smokers," Pharm Biochem Behav 25(6):1181-1184 (1986) LOR-29030 Greenberg, L.A., et al., "The Absorption of Nicotine in Tobacco Smoking," J 00100/9952. Pharm Exp Ther 104:162-167 (1952) LOR-29031 Guyton. Teictbook of Medical Physiology. W.B. Saunders (1971) 00/00/1971 LOR-29032 Haag, H.B., et al., "Recent Advances in the Pharmacology of: Nicotine," 00/00/1944 Virginia Med Monthly 71(5):235-24t (1944) LOR-29033 Hager, B. and Niessner, R., "On the Distribution of Nicotine Between the Gas 02/00/1997 and Particle Phase and its Measurement," Aerosol Science and Technology 26(2):163-174 (Feb. 1997) LOR-29034 Henningfield, J.E.,-"Behavioral Pharmacology of Cigarette.Smoking," In.` 00/00/1984 Advances in Behavioral Pharmacology, Vol. 4, %. Thompson, P.B. Dews and J.E. Barrett (eds.). Academic Press, Inc., New York, pp. 131-210 (1984) LOR-29035 Henningfield, J.E., et al., "Estimation of Available Nicotine Content of Six 00/00/1995., Smokeless Tobacco Products," Tobacco Control 4:57-61 (1995) - LOR-29036 Henningfield, J.E., et al., "Psychopharmacology of Nicotine," tn:. Nicotine ' 0 0/0 011 9 9 3 Addiction: Principles and Management. C.T. Orleans, ef al., (eds.). Chapter 2, pp. 24-45, 1993 LOR-29037_ Hermann, D.R., et al., "Pulmonary Absorption of Instilled Nicotine," Am Rev - 00/00/1990.. Resp Dis 141:A784 (1990) . LOR-29038 Hermann, D.R., et al., "Nicotine Absorption Following Pulmonary Instillation," 0 0/0 011 9 9 0. Am Rev Resp Dis Supplement, 141, 4(2):A334 (1990) LOR-29039 Hoffman, D., et al., "Changes in Cigarette Design and Composition Over, Time 00/00I1984 and How They Influence the Yields of Smoke Constituents," J of Smoking . Related Diseases 6:9-23 (1984) LOR-29040 Holma, B., "Influence of Buffer Capacity and pH-Dependent Rheological : 00I00/1985 Properties of Respiratory Mucus on Health Effects Due to Acidic Pollution," The Science of the Total Environment 41:101-123 (1985) LOR-29041 Huber, G.L., "Physical, Chemical, and Biologic Properties of Tobacco, 00/00/1989 Cigarette Smoke and Other Tobacco Products," Seminars in Respiratory Medicine 10(4):297-332 (1989) LOR-29042 Iwase, et al., "Respiratory Nicotine Absorption in_ Non-Smoking Females 00/00/1991 During Passive Smoking," Int Arch Occup Environ Health 63:134-143 (1991) Page 58 of 79 98287980
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Exhibit Description: Document Name: Date: LOR-29043 Kirk, R.R. and Othmer, D.R., "Encyclopedia of Chemical Technology: Volume 00/00/1955 14 Thermodynamics to Waterproofing," Tobacco pp. 242-261, The Interscience Encyclopedia, Inc., New York, 1955 LOR-29044 Kozlowski, L.T. and Kleiman, R.M., "Effects of Oral pH on Cigarette Smoking," 00/00/1978 Pharmacology, Biochemistry and Behavior 9(4):477-480 (1978) LOR-29045 Larson, P.S., "Metabolism of Nicotine and Nature of Tobacco Smoke Irritants," 00/00/1952 Indus and Eng Chem 44:279-283 (1952) LOR-29046 Larson, P.S. and Silvette, H., "Tobacco Experimental and Clinical Studies, A 00I00/1968 Comprehensive Account of the World Literature," The Williams & Wilkins Company, Sup. 1(1968) LOR-29047 Larson, P.S. and Silvette, H., Tobacco: Experimental and Clinical Studies. A 00/00/1975 Comprehensive Account of the World Literature (Supplement Ill). Cover page, Contents pp. vii-ix and Chapter 1, Absorption and Fate," pp. 1-14, 1975 LOR-29048 Larson, P.S. and Silvette, H., Tobacco: Experimental and Clinical Studies. A 0 010 0/1 9 6 1 Coniprehensive Account of the World Literature. Cover page, Contents pp. viii-xii and Chapter 1, Absorption and Fate," pp. 1-26, 1961 LOR-29049 Levitzky, M.G., Pulmonary Physiology, 3rd Ed. McGraw-Hill (1991) 00/00/1991 LOR-29050 Lewis, D.A., et al., "Diffusion Denuder Method for Sampling Vapor-Phase 10/15/1994 Nicotine in Mainstream Tobacco Smoke," Analytical Chemistry 66(20):3525- 3527 (October 15, 1994) LOR-29051 Liang, C., et al., "Gas/Particle Partitioning of Organic Compounds to 00/00/1996 Environmental Tobacco Smoke: Partition Coefficient Measurements by Desorption and Comparison to Urban Particulate Material," Environmental Science & Technology 30(9):2800-2805 (1996) LOR-29052 Lunell, E., et al., "Nicotine Deposition and Body Distribution from:a Nicotine ° 00/00/1996 Inhaler and a Cigarette Studied with Positron Emission Tomography," Clinical Pharmacology and Therapeutics, Letter to the Editor, 593-594 (1996) LOR-29053 Mangan, G.L. and Golding, J.R., "The Psychopharmacology and 00/00/1984. Psychophysiology of Smoking," In:- The Psychopharmacology of Smoking. Cambridge University Press, Cambridge; Massachusetts, Part il, Chapter 3, pp. 97-140 (1984) - LOR-29054 Markowska, M.M., et al., "Buccal Absorption of Nicotine In Vitro," Proceed 00/00/1993 - Intern Symp Control Rel Bioact Mater 20:454-455 (1993) - LOR-29055 Morie, G.P., "Fraction of Protonated and Unprotonated Nicotine in Tobacco 00/00/1972 Smoke at Various pH Values," Tobacco Science :16:56 (1972) LOR-29056 Olsson, P., et al., "Pharmacokinetics of Nicotine After Intranasal - 00/00/1991 Administration," Effects of Nicotine on Biological Systems, Advances in . . Pharmacological Sciences, pp. 57-61 (1991) _ 11 _ LOR-29057 Pankow, J.F., et al., "Conversion of Nicotine in Tobacco Smoke-to its Volatile 0 0/0 011 9 97 and Available Free-Base Form Through the Action of Gaseous Ammonia," Environmental Science & Technology, 31(8):2428-2433 (1997) LOR-29058 Pharmacia Upjohn Company, "Clinical Pharmacology.and Biopharmaceutic 10/25/1996 Review of Nicotrol Inhaler," NDA:20-714 Review Date October 25, 1996 LOR-29059 Pierce, I.H., "The Absorption of Nicotine in Cigarette Smoking;" The Journal of 00/00/1987 Pharmacology and Experimental Therapeutics 60:114-115 (1987) LOR-29060 Report of Canada's Expert Committee on Cigarette Modifications, Conference 00/00/1996 Proceedings, W.S. Ricker, Ph.D. (ed), Toronto, Ontario, Canada, pp. 1-103, March 1-3, 1996 98287981 Page 59 of 79
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Exhibit Description: Document Name: Date: LOR-29317 Wagner, J.C., G. Berry, J.W. Skidmore, and V. Timbrell. "The Effects of the 0010011974 Inhalation of Asbestos in Rats." British Journal of Cancer 29:252-269, 1974 OR-29318 Webster, I., B. Goldstein, F.S.J. Coetzee, and G.C:H. van Sittert. "Malignant 00/00/1993 Mesothelioma Induced in Baboons by Inhalation of Amosite Asbestos." American Journal of Industrial Medicine 24:659-666, 1993 LOR-29319 Wehner, A.P., R.H. Busch, R.J. Olson, and D.K. Craig. "Chronic Inhalation of 00/00/1975 Asbestos and Cigarette Smoke by Hamsters." Environmental Research 10:368-383, 1975 LOR-29320 Weiss, W. "The Cigarette Factor in Asbestosis." Chest 4:769-770, 1990 00/00/1990 LOR-29321 Weiss, W. "Cigarette Smoking and Diffuse Pulmonary Fibrosis." Archives of 0 0/0 011 96 7 Environmental Health 14:564-568, 1967 LOR-29322 Weiss, W. "Smoking and Pulmonary Fibrosis." Journal of Occupational 00/00/1988 Medicine 30(1):33-39, 1988 - LOR-29323 Weiss, W. "State of the Art. Cigarette Smoke, Asbestos, and Small Irregular 00/00/1984 Opacities." American Reviews of Respiratory Disease 130(2):293-301, 1984 LOR-29324 Weiss, W., and P.A. Theodos. "Pleuropulmonary Disease Among Asbestos 00I00/1978 Workers in Relation to Smoking and Type of Exposure." Journal of Occupational Medicine 20(5):341-345, 1978 LOR-29325 Weiss, W. "Cigarette Smoking, Asbestos, and Pulmonary Fibrosis." America 00/00/1971 Review of Respiratory Disease 104:223-227, 1971 LOR-29326 Weiss, W. "Cigarette Smoking and Diffuse Pulmonary Fibrosis." American 00/00/1969 Review of Respiratory Disease 99:67-72, 1969 LOR-29327 Wright, J.L., and A. Churg. "Morphology of Small-Airway Lesions in Patients 00/00/1984 with Asbestos Exposure." Human Pathology 15:68-74, 1984 LOR-29328 Wright, J.L., V. Tron, B. Wiggs, and A. Churg. "Cigarette Smoke Potentiates 00/00/1988 Asbestos-Induced Airflow Abnormalities." Experimental Lung Research 14(4):537-548, 1988 LOR-29329 _- Yano, E., K. Tanaka, M. Funaki, K. Maeda, C. Matsunaga; and K. Yamaoka. 00/00/1993 "Effect of Smoking on Pleural Thickening in Asbestos Workers." British Journal of Industrial Medicine 50(10):898-901, 1993 LOR-29330 Yoshimura, H., and K. Takemoto. "Effect of Cigarette Smoking and/or N;.. .' 00/00/1991 Bis(2-Hydroxypropyl) Nitrosemine (DHPN) on the Development of Lung and Pleural Tumors in Rats Induced by Administration of Asbestos." Japanese Journal,of Industrial Health 33(2):81-93, 1991 LOR-29331 Black, W.C., "Unexpected Observations on Tumor Size and Survival in Stage 06/0012000 • IA Non-Small Cell Lung Cancer," Chest 117(6): 1532-1534, June 2000 . LOR-29332 Menendez, V., et al.; "Usefulness of Urinary Nuclear Matrix Protein 22 00/00/2000 (NMP22) as a Marker for Transtional Cell Carcinoma of the Bladder," Anticancer Research 20: 1169-1172, 2000 LOR-29333 "Methodology," Chapter ii in: Guide to Clinical preventive Services, 2nd Ed., Report of the U.S. preventive Services Task Force (Philadelphia: Lippincott Williams & Wilkins), pp. xxxix-lv LOR-29334 Mian, C., et al., "Comparison of the Monoclonal UBC-Elisa.Test and the 00/00/2000 NMP22 Elisa Test for the Detection of Urothelial Cell Carcinoma of the Bladder," Urology 55: 223-226, 2000 LOR-29335 Midthun, D.E., et al., "Solitary Pulmonary Nodule: New Face-on an Old 00/00/2000 Problem," J Respir Dis 21(4): 270-276, 2000 OR-29336 Mohr, D.N., "Asymptomatic Microhematuria and Urologic Disease," JAMA 256: 00/00/1986 224-229, 1986 Page 75 of 79 98287997
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Exhibit Description: Document Name: Date: LOR-29337 Mohr, D.N., et al., "Isolated Asystomatic Microhematuria: A Cross-Sectional 00/00/1987 Analysis of Test-Positive and Test-Negative Patients," J Gen Intern Med 2: 318-374, 1987 LOR-29338 "Overview " Chapter i in: Guide to Clinical preventive Services 2nd Ed. . , , , Report of the U.S. preventive Services Task Force (Philadelphia: Lippincott Williams & Wilkins), pp. xxv-xxxviii LOR-29339 Ozen, H. and M.C. Hall, "Bladder Cancer," Curr Opin Oncol 12: 255-259, 2000 00/00/2000 LOR-29340 Sawczuk, I.H., "The Mechanism and Clinical Applications of the NMP22 Tumo 04/00/1999 Marker Immunoassay: A Review," Am Clin Lab, pp. 24-26, April 1999 LOR-29341 Sox, H.C., Jr., "Preventive Health Services in Adults," NEJM;330(22): 1589- 06/0211994 1595, June 2, 1994 LOR-29342 Woolf, S.H., et al., "Introduction," In: Health Promotion and Disease - 00/00/1996 Prevention in Clinical, Practice," Woolf, S.H., et al. (eds.) (Baltimore: Williams & Wilkins, 1996),pp..xxv, xlii, xliii LOR-29343 Woolf, S.H., "What Not to Do and Why," In: Health Promotion and Disease 00/00/1996 Prevention in Clinical Practice," Woolf, S.H., et al. (eds.) (Baltimore: Williams. & Wilkins, 1996), pp. 448-463 LOR-29344 Cancer: Principles & Practice of Oncology 5th ed. ( DeVita, Hellnian and 00/00/1997 Rosenberg ed. 1997) LOR-29345 Cancer Medicine, 3rd ed. (Holland et. al. ed. 1993) 00/00/1993 LOR-29346 Harrison's Principles of Internal Medicine, 13th ed. (Isselbacher et. al. ed. 00/00/1994 1994) LOR-29347 American Joint Committee on Cancer Staging Manual, 5th ed. (Fleming et. al. 00/00/1997 ed. 1997) LOR-29348 Martinez, M.E., et al., "Cigarette Smoking and Alcohol Consumption as Risk 00/00/1995 11 Factors for Colorectal Adenomatous Polyps," JNCI 87(4): 274-279, 1995 LOR-29349 Giovannucci, E., et al., "Alcohol, Low-Methionine-Low-Folate'Diets, and Risk 00/00/1995 of Colon Cancer in Men," JNCI 265-273, 1995 LOR-29350 Bringham, S.A., "Epidemiology and Mechanisms Relating Diet to Risk of . 00/00/1996 Colorectal Cancer," Nutrition Research Reviews 9: 197-239, 1996 LOR-29351 DeCosse, J.J., "Introduction to the National Conference on Colorectal 00/00/1992 Cancer," Cancer Suppl. 70(5): 1205-1228, 1992 LOR-29352 Fernandez, E., et al., "Risk Factors for Colorectal Cancer in Subjects with 00/0011997 Family History of the Disease," Br J Cancer 75(9): 1381-1384, 1997 LOR-29353 Suadicani, P., et al., "Is the Use of Antihypertensives and Sedatives a Major 00/00/1993 Risk Factor for Colorectal Cancer?," Scand J. Gastroenterol 28: 475-481, 1993 LOR-29354 Peters, R.K., et al., "ACase-Control Study of Occupational and Dietary Factors 00/00/1989 in Colorectal Cancer in Young Men by Subsite," Cancer Research 49: 5459- 5468, 1989 LOR-29355 Burt, R.W., "Inherited Susceptibility to Colorectal Cancer," Hospital Practice, 0 010 011 9 8 9 pp.43-51, 1989 LOR-29356 Cannon-Albright, L.A., et al., "Common Inheritance of Susceptibility to Colonic 00/00/1988 Adenomatous Polyps and Associated Colorectal Cancers," NEJM 319: 533- 537, 1988 - LOR-29357 Vogelstein, B., et al., "Genetic Alterations During Colorectal-Tumor 00/00/1988 Development," NEJM 319(9): 525-532, 1988 - Page 76 of 79 98287998
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Exhibit Description: Document Name: Date: LOR-29232 Hammond, E.C., I.J. Selikoff, and H. Seidman. "Asbestos Exposure, Cigarette 00/00/1979 Smoking and Death Rates." Annals New York Academy of Sciences 330:473- 490, 1979 LOR-29_233 Hammond, E.C., O. Auerbach, D. Kerman, and L. Garfinkel. "Effects of 00/00/1970 Cigarette Smoking on Dogs. I. Design of Experiment, Mortality, and Findings in Lung Parenchyma." Archives of Environmental Health 21:740-753, 1970 LOR-29234 Hammond, E.C., and I.J. Selikoff. "Relation of Cigarette Smoking to Risk of 00/00/1973 Death of Asbestos-associated Disease among Insulation Workers in the United States." In, Biological Effects of Asbestos, P. Bogovski, J.C. Gilson, V. Timbrell, and J.C. Wagner, Eds., International Agency for Research on Cancer, Lyon, pp. 312-317, 1973 - LOR-29235 Harries, P.G., F.A.F. Mackenzie, G. Sheers, J.H. Kemp, T.P. Oliver, and D.S. 00/00/1972 Wright. "Radiological Survey of Men Exposed to Asbestos in Naval Yards." British Journal of Industrial Medicine 29:274-279, 1972 LOR-29236 Hedenberg, L., I. Hermansson, M. Liden, and G. Thringer. "Directed Health 00/00/1978> Survey of Asbestos-Exposed Workers." Lakartidningen 75(45):4151-4152, 1978 LOR-29237 Hesterberg, T.W., C. Axten, E.E. McConnell, G. Oberdorster, J. Everitt, W.C. 00/00/1997 Miller, J. Chevalier, G.R. Chase, and P. Thevenaz. "Chronic Inhalation Study of Fiber Glass and Amosite Asbestos in Hamsters: Twelve-month Preliminary Results." Environmental Health Perspectives 105(5):1223-1229, 1997 LOR-29238 Hilt, B., S. Langard, A. Andersen, and J. Rosenberg. "Asbestos Exposure, 00/00/1985 Smoking Habits, and Cancer Incidence Among Production.and Maintenance Workers in an Electrochemical Plant." American Journal of Industrial Medicine 8:565-577, 1985 OR-29239 Hiroshima, K., Y Murai, Y. Suzuki, B. Goldstein, and I. Webster. - 0 0/0 011 9 9 3 "Characterization of Asbestos Fibers in Lungs and Mesotheliomatous Tissues of Baboons Following Long-Term Inhalation," American Journal of Industrial Medicine 23(6):883-901, 1993 LOR-29240 Hnizdo, E. and G.K. Sluis-Cremer. "Effect of Tobacco Smoking on the 00/00/1988 presence of Asbestosis at Postmortem and on the Reading of lrregular Opacities on Roentgenograms in Asbestos-exposed Workers." American Review of Respiratory Disease 138:1207-1212, 1988 LOR-29241 Hobson J.L. Wright and A. Churg. "Active Oxygen Species-Mediate J. 00/00/1990,r , , , Asbestos FiberUptake by Tracheal Epithelial Cells." FASEB Journal 4:3135- 3139, 1990 LOR-29242 Hobson, J., B. Gilks, J. Wright, and A. Churg. "Direct Enhancement by 00/00/1988, Cigarette Smoke of Asbestos Fiber Penetration and Asbestos-lnduced Epithelial Proliferation in Rat Tracheal Explants.". Journal of the National Cancer Institute 80:518-521, 1988 LOR-29243 Humphrey, E.W., S.L. Ewing, J.V. Wrigley, W.F. Northrup, III, T.E. Kersten, 00/00/1981 J.E. Mayer, and R.L. Varco. "The Production of Malignant Tumors of the Lung and Pleura in Dogs from Intratracheal Asbestos Instillation and Cigarette Smoking." Cancer 47:1994-1999, 1981 LOR-29244 Ilgren, E., and E. Chatfield. "Coalinga Fibre - A Short, Amphibole-Free 00/00/1998 Chrysotile." Indoor+Built Environment 7:18-31, 1998 98287991 Page 69 of 79
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Exhibit Description: Document Name: Date: LOR-29245 Jackson, J.H., I. U. Schraufstatter, P.A. Hyslop, K. Vosbeck, R. Sauerheber, 00/00/1987 S.A. Weitzman, and C.G. Cochrane. "Role of Oxidants in DNA Damage: Hydroxyl Radical Mediates the Synergistic DNA Damaging Effects of Asbestos and Cigarette Smoke." Journal of Clinical Investigation 80:1090-1095, 1987 LOR-29246 Kamp, D.W. and Sigmund A. Weitzman, "Asbestosis: Clinical Spectrum and 00/00/1997 Pathogenic Mechanisms," PSEBM 214:12-26, 1997 LOR-29247 A.B. "Mechanisms of Mineral Fibre Carcinogenesis." In, Mechanisms o Kane 00/00/1996 , Fibre Carcinogenesis, A.B. Kane, R. Saracci, and J.D. Wilbourn, Eds., International Agency for Research on Cancer, Lyon, pp. 11-34, 1996 LOR-29248 Kilburn, K.H. "Cigarette Smoking Does Not Produce or Enhance the 00/00/1981 Radiologic Appearance of Pulmonary Fibrosis." American Journal of Industrial Medicine 2:305-308, 1981 LOR-29249 Kilburn, K.H., and R.H. Warshaw. "Airways Obstruction from Asbestos 00/00/1994 Exposure. Effects of Asbestosis and Smoking." Chest 106(4):1061-1070, 1994 LOR-29250 Kilbum, K.H., R. Warshaw, A. Miller, R. Lilis, H.A. Anderson; and I.J. Selikoff. 00/00/1985 "Do Asbestos and Cigarette Smoke Interact Materially in Causing Pulmonary Fibrosis?" American Review of Respiratory Disease 131(Suppl.):A177, 1985 LOR-29251 Kilbum, K.H., R. Lilis, H.A. Anderson, A. Miller, and R.H. Warshaw. 00/00/1986 "Interaction of Asbestos Age and Cigarette Smoking in Producing , , Radiographic Evidence of Diffuse Pulmonary Fibrosis." The American Journal of Medicine 80(3):377-381, 1986 LOR-29252 Kimizuka, G., H. Ohwada, and Y. Hayashi. "Co-carcinogenic Effect of 00/00/1987 Asbestos and Benzo(a)pyrene in the Lung of Hamster." Acta Pathol. Jpn. 37(3):465-474, 1987 OR-29253 Kimizuka, G., and Y. Hayashi. "Combined Effects of Asbestos and Smoking . 00/00/1993 on Hamster Lung." In, Health Risks from Exposure to Mineral Fibres: An International Perspective, G.W. Gibbs, J. Dunnigan, M. Kido; and T. Higashi, Eds., Captus University Publications, North York, Ontario, pp. 254-263, 1993 LOR-29254 Kjuus, H., R. Skjaerven, S. Langard, J.T. Lien, T. Aamodt. "A Case-referent 00/00/1986 Study of Lung Cancer, Occupational Exposures and Smoking." Scandinavian- Journal of Work and Environmental Health 12:203-209, 1986 LOR-29255 Langlands, J.H.M., W.F.M. Wallace,.and M.J.C. Simpson. "Insulation Worker 00/00/1971 in Belfast. 2. Morbidity in Men Still at Work." British Journal of Industrial Medicine 28:217-225, 1971 LOR-29256 Lee, K.P., C.E. Barras, F.D. Griffith, R.S. Waritz, and C.A. Lapin. 00/00/1981 "Comparative Pulmonary Responses to Inhaled Inorganic Fibers with Asbestos and Fiberglass." Environmental Research 24:167-191, 1981 LOR-29257 Leong, B.K.J., R.J. Kociba, H.C. Pernell, R.W. Lisowe, and L:W. Rampy. 00/00/1978 "Induction of Pulmonary Carcinoma in Rats by Chronic Inhalation of Dust from Pulverized Asbestos Pipe Covering." Journal of Toxicology and Environmental Health 4:645-659, 1978 LOR-29258 Liddell, F.D.K., and G.W. Gibbs. "Radiological Changes and Fibre Exposure 00/00/1982 in -Chrysotile Workers Aged 60-69 Years at Thetford Mines." Annals of Occupational Hygeine 26(1-4):889-898, 1982 LOR-29259 Liddell, F.D.K., A.D. McDonald, and J.C. McDonald. "Dust Exposure and Lun 00/00/1998 Cancer in Quebec Chrysotile Miners and Millers." Annals of Occupational Hygiene 42(1):7-20, 1998 ~- ---- Page 70 of 79 98287992
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Exhibit Description: Document Name: Date: LOR-29301 Saracci R. "Asbestos and Lung Cancer: An Analysis of the Epidemiological 0 010 011 9 7 7 , Evidence on the Asbestos-Smoking Interaction." International Journal of Cancer 20:323-331, 1977 LOR-29302 Sekhon, H., J. Wright, and A. Churg. "Effects of Cigarette Smoke and . 00/00/1995 Asbestos on Airway, Vascular and Mesothelial Cell Proliferation." Internationa Journal of Experimental Pathology 76:411-418, 1995 LOR-29303 Selikoff, I.J.; H. Seidman, and E.C. Hammond. "Mortality Effects of cigarette 00/00/1980 Smoking Among Amosite Asbestos Factory Workers." Journal of the National Cancer Institute 65(3):507-513, 1980 LOR-29304 Selikoff, I.J:, J. Churg, and E.C. Hammond. "Asbestos Exposure and 00/0011964 Neoplasia." JAMA 188(1):22-26, 1964 LOR-29305 Selikoff, I.J., W.J. Nicholson, and R. Lilis. "Radiological Evidence of Asbestos 00/00/1980 Disease Among Ship Repair Workers." American Journal of Industrial Medicine 1:9-22, 1980 LOR-29306 Selikoff, I.J., Hammond, E.C., and Churg, J. "Asbestos Exposure, Smoking; 00/00/1968 and Neoplasia." JAMA 204(2):104-110, 1968 LOR-29307 Shabad,t.M., L.N. Pylev, L.V. Krivosheeva, T.F. Kulagina, and B.A. 00/00/1974 Nemenko. "Experimental Studies on Asbestos Carcinogenicity." Journal of the National Cancer Institute 52(4):1175-1187, 1974 LOR-29308 Sluis-Cremer, G.K., P.A. Hessel, and E. Hnizdo. "Factors Influencing the 00/00/1989 Reading of Small Irregular Opacities in a Radiological Survey of Asbestos Miners in South Africa." Archives of Environmental Health 44(4):237-243, 1989 LOR-29309 Smith, W.E., L. Miller, and J. Churg. "An Experimental Model for Study of 00/00/1970 Cocarcinogenesis in the Respiratory Tract." In, Morphology of Experimental Respiratory Carcinogenesis, P. Nettesheim, M.B. Hanna, Jr., J.W. Deatherage, Jr., and Oak Ridge National Laboratories, Eds., U.S. Atomic Energy Commission, Division of Technical Information, pp. 299-316, 1970 LOR-29310 Steenland, K., and M. Thun: "Interaction between Tobacco;Smoking and 00/00/1986 Occupational Exposures in the Causation of Lung Cancer." Journal of Occupational Medicine 28(2):110-118;'1986 LOR-29311 Suslova, T.B., Z.P. Cheremisina, and L.G. Korkina. "Free Radical Generation 00/00/1994 during Interaction of Chrysotile Asbestos with Natural Compounds." Environmental Research 66:222-234, 1994 LOR-29312 Tron, V., J.L. Wright, N. Harrison, B. Wiggs, and A. Churg. "Cigarette Smoke 00/00/1987 Makes Airway and Early Parenchymal Asbestos-Induced Lung Disease Worse - in the Guinea Pig." American Review of Respiratory Disease 136:271-275, 1987 LOR-29313 Viallat, J.R., and C. Boutin. "Radiographic Changes in Chrysotile Mine and 00/00/1980 Mill Ex-workers in Corsica. A Survey 14 Years after Cessation of Exposure." Lung 157(3):155-163, 1980 LOR-29314 Vainio, H., and P: Boffetta. "Mechanisms of the Combined Effect of Asbestos 0 0/0 011 9 94 and Smoking in the Etiology of Lung Cancer." Scandinavian Journal of Work and Environmental Health 20:235-242, 1994 LOR-29315 Wagner, J.C. "Tumours in-Experimental Animals Following Exposure to 00/00/1976 Asbestos Dust," Annales d'Anatomie Pathologique 21(2):211-214, 1976 LOR-29316 Wagner, J.C. "The Pathogenesis of Tumors Following the Intrapleural 00/00/1970 Injection of Asbestos and Silica." Morphol. Exp. Respir. Carcinog. 0(0):347- 358, 1970 Page 74 of 79 98287996
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Exhibit Description: Document Name: Date: LOR-29372 Lagergren, J., Bergstrom, R., Lindgren, A. and Nyren, 0., "Symptomatic 00/00/1999 Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma," The New England Journal of Medicine 340(1_1): 825-831, 1999 LOR-29373 Cohen, S. and Parkman, H.P., "Heartburn --A Serious Symptom," The New 00/00/1999 England Journal of Medicine 340(11): 878-879, 1999 LOR-29374 Lagergren, J., Bergstrom, R. and Nyren, 0., "Association between Body Mass 00/00/1999 and Adenocarcinoma of the Esophagus and Gastric Cardia," Annals of Internal Medicine 130(11): 883-890, 1999 LOR-29375 EI-Serag, H.B. and Sonnenberg, A., "Opposing Time Trends of Peptic Ulcer , 00/00/1998 and Reflux Disease," Gut 43: 327-333, 1998 LOR-29376 EI-Serag, H.B., Sonnenberg, A., Jamal, M.M., Inadomi, J.M., Crooks, L.A and 00/00/1999 Feddersen, R.M., "Corpus Gastritis is Protective Against Reflux Oesophagitis," Gut 45: 181-185, 1999 LOR-29377 McColl, K.E.L., EI-Omar, E. and Gillen, D., "Interactions between H: pylori 00700/1998 Infection, Gastric Acid Secretion and Anti-Secretory Therapy," erapy," British Medical Bulletin 54(1): 121-138, 1998 LOR-29378 , Labenz, J., Blum, A:L., Bayerdorffer, E., Meining, A., Stolte,.M: and Borsch, G: 00/00/1997 "Curing Helicobacter pylori Infection in Patients with Duodenal Ulcer May Provoke Reflux Esophagitis," Gastroenterology 112(5): 1442-1447, 1997 LOR-29379 Richter, J.E., Falk, G.W. and Vaezi, M.F., "Helicobacter pylori and . 00/00/1998 Gastroesophageal Reflux Disease: The Bug May Not Be All Bad," The _ American Journal of Gastroenterology 93(10: 1800-1802, 1998 LOR-29380 Blaser, M.J., "In a World of Black and White, Helicobacter pylori Is Gray," 00/00/1999 Annals of Internal Medicine 130(8): 695-697, 1999 LOR-29381 Blaser, M.J., "Helicobacters are Indigenous to the Human Stomach: Duodena 00/00/1998 Ulceration is Due to Changes in Gastric Microecology in the Modem Era," Gut 43: 721-727, 1998 LOR-29382 Tysk, C. and Jarnerot, G., "Has Smoking Changed the Epidemiology of 00/00/1992 Ulcerative Colitis?" Scand. J. Gastroenterol. 27: 508-512, 1992 LOR-29383 , Silverstein, M.D., Lashner, B.A. and Hanauer, S.B., "Cigarette Smoking and 00/00/1994 Ulcerative Colitis: A Case-Control Study," Mayo Clin. Proc. 69: 425-429; 1994 LOR-29384 Van Erpecum, K.J., Smits, S.J.H.M., Van de_ Meeberg, P.C., Linn, F.H.H., 00/00_ /1996 Wolfhagen, F.H.J., vanBerge-Henegouwen, G.P. and Algra, A.; "Risk of - Primary Sclerosing Cholangitis Is Associated with Nonsmoking Behavior," Gastroenterology 1:10(5): 1503-1506, 1996 LOR-29385 Green, J.T., Rhodes, J., Ragunath, K., Thomas, G.A.O., Williams, G.T., Mani,° 00/00/1998 V., Feyerabend, C. and Russell, M.A.H., "Clinical Status of Ulcerative Colitis in Patients Who Smoke," The American Journal of Gastroenterology 93(9): ° 1463-1467, 1998 LOR-29386 Boyko, E.J., Perera, D.R., Koepsell, T.D., Keane, E.M. and Inui, T.S., "Effects 00/00/1988 of Cigarette Smoking on the Clinical Course of Ulcerative Colitis," Scand. J. Gastroenterol. 23: 1147-1152, 1988 LOR-29387 Thomas, G.A.O., Rhodes, J. and Green, J.T., "Inflammatory Bowel Disease 00/00/1998 and Smoking -- A Review," Am. Coll. of Gastroenterology 93(2): 144-149, 1998 LOR-29388 Hanauer, S.B.; "No Butts About It: Put the Fire Out By Lighting Up," 00/00/1998 Inflammatory Bowel Disease 4(4): 326, 1998 -- Page 78 of 79 98288000
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Exhibit Description: Document Name: Date: LOR-29260 Liddell, D. G. Eyssen, D. Thomas and C. McDonald. "Radfological Changes 00/00/1977 , , over 20 Years in Relation to Chrysotile Exposure in Quebec." In, Inhaled Particles. IV., W.H. Walton and B. McGovern, Eds., Pergamon Press, Oxford, pp. 799-813, 1977 LOR-29261 Liddell, F.D.K., D.C. Thomas, G.W. Gibbs, and J.C. McDonald. "Fibre 00/00/1984 Exposure and Mortality from Pneumoconiosis, Respiratory and Abdominal Malignancies in Chrysotile Production in Quebec, 1926-75." Annals Academy of Medicine, Singapore 13(2)(Suppl.):340-344, 1984 LOR-29262 Lilis, R., I.J. Selikoff, Y. Lerman, H. Seidman, and S.K. Gelb: "Asbestosis: 00/00/1986 Interstitial Pulmonary Fibrosis and Pleural Fibrosis in a Cohort of Asbestos Insulation Workers: Influence of Cigarette Smoking." American Journal of Industrial Medicine 10:459-470, 1986 LOR-29263 Markowitz, S.B., A. Morabia, R. Lilis,.A. Miller, W.J. Nicholson, and S. Levin. 00/00/1997 "Clinical Predictors of Mortality from Asbestosis in the North American Insulator Cohort, 1981 to 1991." American Journal of Respiratory and Critical Care Medicine 156:101-108, 1997 LOR-29264 Martischnig, K.M., D.J. Newell, W.C. Barnsley, W.K. Cowan, E.L. Feinmann, 00/00/1977 E. Oliver. "Unsuspected Exposure to Asbestos and Bronchogenic Carcinoma." British Medical Journal 1:746-749, 1977 LOR-29265 McConnell, E.E., H.J. Chevalier, T.W. Hesterberg, J.G. Hadley, and R.W. 00/00/1994 Mast. "Comparison of the Effects of Chrysotile and Crocidolite Asbestos in Rats After Inhalation for 24 Months." In, Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract, ILSI Press, Washington, D.C., pp. 461 467, 1994 LOR-29266 McDonald, J.C., F.D.K. Liddell, G.W. Gibbs, G.E. Eyssen, and A.D. McDonald. 00/00/1980 "Dust Exposure and Mortality in Chrysotile Mining 1910-75." British Journal o , Industrial Medicine 37:11-24, 1980 LOR-29267 McFadden D., J: Wright B. Wiggs and A. Churg. "Cigarette Smoke 00/00/1986 , , , Increases the Penetration of Asbestos Fibers Into Airway Walls:" American Journal of Pathology 123:95-99,1986 LOR-29268 McFadden D. J:L. Wright B. Wiggs and A. Churg. "Smoking,Inhibits 00/00/1986 , , , , Asbestos Clearance." American Review of Respiratory Disease 133:372-374, 1986 LOR-29269 McMillan, G.H.G., R.J. Pethybndge, and G. Sheers. "Effectof Smoking on 00/00/1980 Attack Rates of Pulmonary and Pleural Lesions Related to Exposure to Asbestos Dust." British Journal of Industrial Medicine 37:268-272, 1980 . LOR-29270 Meurman, L.O., R: Kiviluoto, M. Hakama. "Combined Effect of Asbestos 00/00/1979 Exposure and Tobacco Smoking on Finnish Anthophyllite Miners and Millers.'+ Annals New York Academy of Sciences 30:491-495, 1979 LOR-29271 Miller, L., W.E. Smith, and S.W. Berliner. "Tests for Effect of Asbestos on 00/00/1965 Benzo[a]pyrene Carcinogenesis in the Respiratory. Tract." Annals of the New York Academy of Science 132:489-500, 1965 LOR-29272 Morimoto, Y., M. Kido, I. Tanaka, A. Fujino, T. Higashi, and Y. Yokosaki. 00/00/1993 "Synergistic Effects of Mineral Fibres and Cigarette Smoke on the Production of Tumour Necrosis Factor by Alveolar Macrophages of Rats." British Journal of Industrial Medicine 50:955-960, 1993 98287993 Page 71 of 79
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Exhibit Description: Document Name: Date: LOR-29285 Pastorino, U.,-F. Berrino, A. Gervasio, V. Presenti, E. Riboli and P. Crosignani. 00/00/1984 "Proportion of Lung Cancers Due to Occupational Exposure." International Journal of Cancer 33:231-237, 1984 LOR-29286 J.L. "Smoking and Duration of Asbestos Exposure in the Production o Pearle 00/00/1982 , Functional and Roentgenographic Abnormalities in Shipyard Workers." . Journal of Occupational Medicine 24(1):37-40, 1982 LOR-29287 Platek, S.F., D.H. Groth, C.E. Ulrich, L.E. Stettler; M.S. Finnell, and NI: Stoll. 00/00/1985 "Chronic Inhalation of Short Asbestos Fibers." Fundamental and Applied Toxicology 5(2):327-340, 1985 LOR-29288 Raithel, H.J., D. Weltle, H. Bohlig, and H. Valentin. "Health Hazards from Fine 00/00/1989 Asbestos Dusts. An Analysis of 70656 Occupational Preventive Medical Investigations from 1973 to the End of 1986." International Archives of Occupational and Environmental Health 61:527-541, 1989 LOR-29289 . Reeves, A.L., H.E. Puro, R.G. Smith, and A.J, Vorw.ald: "Experimental 00/00/1971 Asbestos Carcino enesis." Environmental Research 4:496-511, 1971 . LOR-29290 Reeves, A.L., H.E. Puro, and R.G. Smith. "Inhalation Carcinogenesis from 00/00/1974 Various Forms of Asbestos." Environmental Research 8:178-202, 1974 LOR-29291 Reeves,.A.L. "The Carcinogenic Effect of Inhaled Asbestos. Fibers;' Annals o 00/00/1976 Clinical and Laboratory Science 6(5):459-466, 1976 LOR-29292 Reif, A.E. "Synergism in Carcinogenesis." Journal of the National Cancer 00/00/1984 Institute 73(1):25-39, 1984 LOR-29293 Roggli, V.L., and P.C. Pratt. "Asbestosis." In, Pathology of Asbestos- 00/00/1992 Associated Diseases, V.L. Roggli, S.D. Greenberg, and P.C. Pratt, Eds. Little, Brown and Company, Boston, pp. 77-108, 1992 LOR-29294 Rom, W.N., W.D. Travis, and A.R. Brody. "Cellular and Molecular Basis of the 00/00/1991 Asbestos-related Diseases." American Review of Respiratory Disease : 143:408-422, 1991 LOR-29295 Rosenstock, L., S. Barnhart, N.J. Heyer, D.J. Pierson, and L:D: Hudson: "The 00/00/1988 Relation among Pulmonary Function, Chest Roentgenographic Abnormalities, and Smoking Status in an Asbestos-exposed Cohort." American Review.of Respiratory Disease 138:272-277, 1988 LOR-29296 Rossiter, C.E., J.R. Heath, and P.G. Harries. "Royal Naval Dockyards 00/00/1980 Asbestosis Research Project: Nine-year Follow.-up of Men Exposed to Asbestos in Devonport Dockyard." Journal of the Royal Society of Medicine 73(5):337-344, 1980 LOR-_29297 Rossiter, C.E., and P.G. Harries. "UK Naval Dockyards Asbestosis Study:. 00/00/1979 Survey of the Sample Population Aged 50-59 Years." British Journal of Industrial Medicine 36:281-291, 1979 LOR-29298 _ Rubino, G.E., M. Newhouse, R. Murray,-G. Scansetti, G. Piolatto, and G. 0 010 011 9 7 9 Aresini. "Radiologic Changes after Cessation of Exposure Among Chrysotile Asbestos Miners in Italy." Annals of the New York Academy of Sciences 330:157-161, 1979 LOR-29299 Samet, J.M., G.R. Epler, E.A. Gaensler, and B. Rosner. "Absence of 00/00/1979 Synergism between Exposure to Asbestos and Cigarette Smoking in Asbestosis." American Review of Respiratory Disease 120(1):75-82; 1979 LOR-29300 Saracci, R. "The Interaction of Tobacco Smoking and Other Agents in Cancer 00/00/1987 Etiology." Epidemiologic Reviews 9:175-193, 1987 98287995 Page 73 of 79
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Exhibit Description: Document Name: Date: LOR-29273 Morimoto, Y., et al., "Expression of Matrix Metalloproteinases, Tissue 00/00/1997 Inhibitors of Metalloproteinases, and Exracellular Matrix mRNA Following Exposure to Mineral Fibers and Cigarette Smoke in Vivo," Environ Health Perspect 105(Suppl: 5): 1247-1251, 1997 LOR-29274 Morimoto, Y., Z. Nambu, H. Hori, T. Tsuda, H. Yamato, Ti Higashi, Y. 00/00/1996 Yokosaki, M. Kido, and I. Tanaka. "Chronic Exposure to Cigarette Smoke Inhibits the Stimulating Effects of Mineral Fibers on the Production of Tumor Necrosis Factor by Alveolar Macrophages of Rats." International Journal of Occupational and Environmental Health 2:95-98, 1996 LOR-29275 Mossman, B.T., G.S. Cameron, and L.P. Yotti. "Cocarcinogenic and Tumor 00/00/1985 Promoting Properties of Asbestos and Other Minerals in Tracheobronchial , Epithelium." In, Carcinogenesis --A Comprehensive Survey, Vol. 8, M.J. Mass, D.G. Kaufman, J.M. Siegfried, V.E. Steele, and S. Nesnow, Eds., Rave Press, New York, pp. 217-238, 1985 LOR-29276 Mossman, B.T., A. Eastman, and E. Bresnick. "Asbestos and Benzo(a)pyrene 00/00/1984 Act Synergistically to Induce Squamous Metaplasia and Incorporation of [3H]thymidine in Hamster Tracheal Epithelium." Carcinogenesis 5(11):1401 - 1404,1984 LOR-29277 Mossman, B.T., A. Eastman, J. M. Landesman, and E. Bresnick. "Effects of 00/00/1983 Crocidolite and Chrysotile Asbestos on Cellular Uptake and Metabolism of Benzo(a)pyrene in Hamster Tracheal Epithelial Cells." Environmental Health Perspectives 51:331-335, 1983 LOR-29278 Mossman, B.T., and A. Churg. "Mechanisms in the Pathogenesis of 00/00/1998 Asbestosis and Silicosis." American Journal-of Respiratory and Critical Care Medicine 157:1666-1680, 1998 OR-29279 Mossman B. "Asbestos: Mechanisms of Toxicity and Carcinogenicity in the 00/00/1983 , Respiratory Tract." Annual Review of Pharmacology and Toxicology 23:595- 615, 1983 LOR-29280 Muhle, H., B. Bellmann, K.R. Spurny, and F. Pott. "Inhalation Experiments on 00/00/1989 Retention and Lung.Clearance of Asbestos in Combination with Cigarette= Smoking." In, Biological Interaction of Inhaled Mineral Fibers and Cigarette - Smoke, A.P. Wehner and D.L. Felton, Eds., Battelle Press, Columbus, OH, pp 183-193, 1989 LOR-29281 Muhle,.H., F. Pott, B. Bellmann, S. Takenaka, and U. Zeim. "Inhalation and , 00/00/1987 Injection Experiments in Rats to Test the Carcinogenicity of MMMF." Annals of Occupational Hygeine 31(48):755-764, 1987 LOR-29282 Nicholson, W.J., I.J. Selikoff, H: Seidman, R. Lilis, and P: Formby. "Long- 00/00/1979 Term Mortality Experience of Chrysotile Miners and Millers in Thetford Mines, Quebec." Annals New York Academy of Sciences 330:11-21, 1979 LOR-29283 Oberdorster, G. "Evaluation and Use of Animal Models to Assess- 00/00/1996 Mechanisms of Fibre Carcinogenicity." In, Mechanisms of Fibre Carcinogenesis, A.B. Kane, R. Saracci, and J.D. Wilbourh, Eds., International Agency for Research on Cancer, Lyon, pp. 107-125, 1996 LOR-29284 Oksa, P., M.S. Huuskonen, J. Jarvisalo, M. Klockars, A. Zitting, H. Suoranta, 00/00/1998 A. Tossavainen, K. Vattulainen, and P. Laippala.. "Follow-up of Asbestosis patients and Predictors for Radiographic Progression." International Archives of Occupational and Environmental Health 71:465-471, 1998 98287994 Page 72 of 79
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Exhibit Description: Document Name: Date: LOR-29217 Davis, J.M.G., J. Addison, R:E. Bolton, K. Donaldson, and A.D. Jones. 00/00/1986 "Inhalation and Injection Studies in Rats Using Dust Samples from Chrysotile Asbestos Prepared by a Wet Dispersion Process." British Journal of Experimental Pathology 67:113-129, 1986 - LOR-29218 Davis, J.M.G., J. Addison, R.E. bolton, K. Donaldson, A.D. Jones, and T. 0 0/0 011 9 86 Smith. "The Pathogenicity of Long Versus Short Fibre Samples of Amosife Asbestos Administered to Rats by Inhalation and Intraperitoneal Injection." British Journal of Experimental Pathology 67:415-430, 1986 LOR-29219 Davis, J.M. "Mixed Fibrous and Non-fibrous Dust Exposures and Interactions 00/00/1996 Between Agents in Fibre Carcinogenesis." In, Mechanisms of Fibre Carcinogenesis, A.B. Kane, R. Saracci, and J.D. Wilbourn, Eds., International Agency for Research on Cancer, Lyon, pp. 127-135, 1996 LOR-29220 Davis, J.M.G:, and A.D. Jones. "Comparisons of the Pathogenicity of Long 0 0/0 011 9 8 8 and Short Fibres of Chrysotile Asbestos in Rats." British Journal of Experimental Pathology 69:717-737, 1988 LOR-29221 Davis, J.M.G., R.E. Bolton, A.N. Douglas, A.D. Jones; and •T. Smith. "Effects 00/00/1988 of Electrostatic Charge on the Pathogenicity of Chrysotile Asbestos." British" . Journal of Industrial Medicine 45:292-299, 1988 LOR-29222 DeKlerk, N.H., A.W. Musk, B.K. Armstrong, M.S.T. Hobbs. "Smoking, 00/00/1991 Exposure to Crocidolite and the Incidence of Lung Cancer and Asbestosis." British Journal of Industrial Medicine 48:412-417, 1991 LOR-29223 Denizeau, F., M. Marion, G. Chevalier, and M.G. Cote. "Genotdxicity of 0 010 0/1 9 8 5 Dimethylnitrosamine in the Presence of Chrysotile Asbestos UICC B and_ Xonotlite." Carcinogenesis 6(12):1815-1817, 1985 LOR-29224 Dick, J.A., W.K.C. Morgan, D.F.C. Muir, R.B. Reger, and N. Sargent. "The 00100/1992 Significance of.lrregular Opacities on the Chest Roentgenograrn." Chest, 102(1):251-260, 1992 . LOR-29225 Ducatman, A.M., B.F. Withers; and W.N: Yang. "Smoking and` 00/00/1990= Roentgenographic Opacities in US Navy Asbestos Workers." Chest 97:810-- 813, 1990 LOR-29226 Ehrlich, R., R. Lilis, E. Chan, W.J. Nicholson, and I.J. Selikoff. "Long Term 0010011992 Radiological Effects of Short Term Exposure to Amosite Asbestos among" Factory Workers." British Journal of Industrial Medicine 49:268-275, 1992 LOR-29227 Elmes, P.C. "Relative Importance of Cigarette Smoking in Occupational Lung.. 0 010 0/1 9 81 Disease." British Journal of Industrial Medicine 38:1-13, 1981 LOR-29228_ Erren, T.C., M. Jacobson, and C. Piekarski. "Synergy Between Asbestos and 00/00/1999 Smoking on Lung Cancer Risks." Epidemiology 10(4):405-411, 1999 LOR-29229 Feron; V.J., C.F. Kuper, B.J. Spit, P.G. J. Reuzel, and R.A.,1Noutersen. "Glas 00/00/1985 Fibers and Vapor Phase Components of Cigarette Smoke as Cofactors in . Experimental Respiratory Tract Carcinogenesis." In, Carcinogenesis --A_ Comprehensive Survey. Volume 8. Cancer of the Respiratory Tract. Predisposing Factors, M.J. Mass, D.G. Kaufman, J.M. Siegfried, V.E. Steele, and S. Nesnow, Eds., Raven Press, New York, pp. 93-118, 1985 LOR-29230 Goldstein B., R.E.G. Rendall, and I. Webster. "A Comparison of the Effects of 00/00/1983 Exposure of Baboons to Crocidolite and Fibrous-Glass Dusts." Environmental Research 32:344-359, 1983 LOR-29231 Goldstein, B., and F.S.J. Coetzee. "Experimental Malignant Mesothelioma in 00/00/1990 Baboons." South African Journal of Science 36(2):89-93, 1990 98287990 Page 68 of 79
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Exhibit Description: Document Name: Date: LOR-29358 Kotake, K., et al., "Relation of Family History of Cancer and Environmental 00/00/1995 Factors to the Risk of Colorectal Cancer: A Case-Control Study," Jpn J Clin Oncol 25: 195-202, 1995 LOR-29359 Bell, D.A., et al., "Polyadenylation Polymorphism in the Acetyltransferase 1 00/00/1995 Gene (NATI) Increases Risk of Colorectal Cancer," Cancer Res 55: 3537- 3542,.1995 LOR-29360 Lang, N.P., et al., "Rapid Metabolic Phenotypes for Acetyltransferace and 00/00/1994 Cytochrome. P4501A2 and Putative Exposure to Food-borne Heterocyclic Amines Increase the Risk for Colorectal Cancer or Polyps," Cancer Epidemiol, Biomarkers & Prevention 3: 673-682, 1994 LOR-29361 Kato, I., et al., "A Comparative Case-Control Study of Colorectal Cancer and 00/00/1990 Adenoma," Jpn J Cancer Res 81: 1101-1108, 1990' LOR-29362 Blot, W.J., Devesa, S.S., Kneller, R.W. and Fraumeni, J.F., "Rising Incidence 00I00/1991 of Adenocarcinoma of the Esophagus and Gastric Cardia," JAMA 265(10): 1287-1289, 1991 LOR-29363 Pera, M., Cameron, A.J., Trastek, V.F., Carpenter, H.A. and Zinsmeister, A.R., 00/00/1993 "Increasing Incidence of Adenocarcinoma of the Esophagus and Esophagogastric Junction," Gastroenterology 104(2): 510-513, 1993 LOR-29364 Moyana, T.N. and Janoski, M., "Recent Trends in the Epidemiology of 00/00/1996 Esophageal Cancer. Comparison of Epidermoid- and Adenocarcinomas," Annals.of Clinical and Laboratory Science 26(6): 480-486, 1996 LOR-29365 Sharma, V.K., Chockalingam, H., Hornung, C.A., Vasudeva, R. and Howden, 00/00/1998 C.W.,<"Changing Trends in Esophageal Cancer: A 15-Year Experience in a Single Center," The American Journal of Gastroenterology 93(5): 702-705, 1998 . OR-29366 Devesa, S.S., Blot, W.J. and Fraumeni, J.F., "Changing Patterns in the 00/00/1998 Incidence of Esophageal and Gastric Carcinoma in the United States," Cancer = 83(10): 2049-2053, 1998 LOR-29367 " Blot, W:J: and McLaughlin, J.K., "The Changing Epidemiology of Esophageal 00/00/1999 Cancer," Seminars in Oncology 26(5, Suppl. 15): 2-8, 1999 LOR-29368 Cameron, A.J., "Epidemiology of Columnar-Lines Esophagus and- 00/00/1997 Adenocarcinoma," Gastroenterology Clinics of North America 26(3): 487-494,- ,- 1997 LOR-29369 Zhang, Z.-F., Kurtz, R.C., Sun, M., Karpeh, M., Yu, G.-P., Gargon, Nr, Fein, , 00/00/1996 J.S., Georgopoulos, S.K. and Harlap, S., "Adenocarcinomas of the Esophagus and Gastric Cardia: Medical Conditions,-Tobacco, Alcohol, and -., Socioeconomic Factors," Cancer Epidemiology, Biomarkers & Prevention 5: 761"-768 1996 LOR-29370 Zhang, Z.-F., Kurtz, R.C. and Marshall, J.R., "Cigarette Smoking and 00/00/1997 Esophageal and Gastric Cardia Adenocarcinoma," Journal of the National Cancerlnstitute 89(17): 1247-1249, 1997 LOR-29371 Vaughan, T.L., Farrow, D.C., Hansten, P.D., Chow, W.-H., Gammon, M.D., 00/00/1998 Risch, H:A., Stanford, J.L., Schoenberg, J.B., Mayne, S.T:, Rotterdam, H., Dubrow, R., Ahsan; H., West, A.B., Blot, W.J. and Fraumeni, J.F., "Risk of Esophageal and Gastric Adenocarcinomas in Relation to Use of Calcium Channel Blockers, Asthma Drugs, and Other Medications that Promote Gastroesophageal Reflux," Cancer Epidemiology, Biomarkers & Prevention 7: : 749-756; 1998 98287999 Page 77 of 79
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Exhibit Description: Document Name: Date: LOR-29203 Bozelka, B.E., P. Sestani, H.R. Gaumer, Y. Hammad, C.J. Heather, and J.E. 00/00/1983 Salvaggio. "A Murine Model of Asbestosis." American Journal of Pathology 112:326-337, 1983 LOR-29204 Brody A.R. "Asbestos-induced Lung Disease." Environmental Health 00/00/1993 , Perspectives 100:21-30, 1993 LOR-29205 Campbell, M.J., and J.H.M. Langlands. "Analysis of a Follow-up Study. An 00/00/1982 Example from Asbestos-exposed Insulation Workers." Scandinavian Journal of Work and Environmental Health 8(suppl. 1):43-47, 1982 LOR-29206 W. and J. Kong. "A Retrospective Mortality Cohort Study of Chrysotile Cheng 00/00/1992 , Asbestos Products Workers in Tianjin 1972-1987." Environmental Research 59:271-278, 1992 LOR-29207 Churg, A., J.-P. Sun, and K. Zay. "Cigarette Smoke Increases Amosite 00/00/1998 Asbestos Fiber Binding to the Surface of Tracheal Epithelial Cells." American Journal of Physiology 275(Lung Cellular and Molecular Physiology 19):L502- L508, 1998 LOR-29208 Churg, A., et al., "Effects of Fiber Size on Short-Term Clearance of Asbestos 00/0011997 from the-Lungs of Smoking and Nonsmoking Guinea Pigs," Am Rev Respir Di 135(4, pt. 2) (Suppl.): A19, 1997 LOR-29209 Churg, A., V. Tron, and J.L. Wright. "Effects of Cigarette Smoke Exposure on 00/00/1987 Retention of Asbestos Fibers in Various Morphologic Compartments of the : Guinea Pig Lung." American Journal of Pathology 129(2):385-393, 1987 LOR-29210 Churg, A., J. Hobson, K. Berean, and J. Wright. "Scavengers of Active O0100/1989 Oxygen Species Prevent Cigarette Smoke-Induced Asbestos Fiber Penetration in Rat Tracheal Explants." American Journal of Pathology 135(4):599-603, 1989 OR-29211_ Churg, A., J.L. Wright, J. Hobson, and B. Stevens. "Effects of Cigarette 0010 0/1 9 9 2 Smoke on the Clearance of Short Asbestos Fibres from the Lung and a Comparison with the Clearance of Long Asbestos Fibres." - International Journal of Experimental Pathology.73(3):287-297, 1992 LOR-29212 Churg, A., J. Hobson, and J. Wright. "Effects of Cigarette Smoke Dose and 0010011990, Time after Smoke Exposure on Uptake of Asbestos Fibers by Rat Tracheal : Epithelial Cells." American Journal of Respiratory Cell and Molecular Biology 3:265-269, 1990 LOR-29213 Cordier, S., G. Theriault, and S. Provencher. "Radiographic Changes in a 00/00/1984 : Group of Chrysotile Miners and Millers Exposed to Low Asbestos Dust . Concentrations." British Journal of Industrial Medicine 41(3):384-388, 1984 ° LOR-29214 Darroch;:J. "Biologic Synergism and Parallelism." American Journal of 00/0071997 Epidemiology 145(7):661-668, 1997 LOR-29215 Dave, S.K., N.B. Ghodasara, N. Mohanrao, G.C. Patel, and B;D. Patel. "The 00/00/1997 Relation of Exposure to Asbestos and Smoking Habit with Pulmonary Function Tests and Chest Radiograph." Indian Journal of Public Health 41(1):16-24, 1997 LOR-29216 Davis, J.M.G., D.M. Brown, R.T. Cullen, K. Donaldson, A.D. Jones, B.G. Miller 0 010 0/1 9 9 6 C. Mclntosh, and A. Searl. "A Comparison of Methods of Determining and Predicting the Pathogenicity of Mineral Fibers."- Inhalation Toxicology 8:747- 770, 1996 . 98 " Page 67 of 79 287989

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