Tobacco Documents Online

Ysa abofa autii¢e ahovs the aagaratioa into v2usa. SSS. Ss the appzmfmh. stagb of this iur.at3y tiaa at ps`aaanL. Jsa-Ehec Ycrt riii Ssialade att.--,pts to repanta ths nriaas aao,.aca af .arh alaas fTaa asah ath.r Df fraatiom2 3:ati2i.atf oa ardlm aTstaylisat/ca .ai to la.atit~r :3ea Di the pr.gsttt/aa at suitat$a aariratisfs. . W}iti+R5.L9 PtLG'i.^.3£Z93S (s7 It fs 2al2moi thet the aaij7.is of the yaaeasst phaas is a.Mtia3v ooq2etb bzaept Sar the zarSaisa of the ocrbca - aoansids Sntetaimtiou ae-. oao.esarT hq iha Siaeo*err of a.zszT '~ rclatis aubateme a.atianad ia pert 2. fiais .iIS iaraits aoa27sie at the ocrqocai. ta. iadira-peatazide stda# tur 3star- aLning GC haa rat 7.t bs.n tne3 for trc raaaaas (1) it s. : sthoi ha+.d oa ths x.dnaing pzepertia. of eaxLCa maatiia aai isa *.hszafor. aat .4eeifls enl (2) ecaatmation of the nsaaaasrJ eq;tiyaaa: vn•sL` he a tis aaaaasing ap.rntion sfilis pttrohsss of the bcaeasar7 .qt€ipxat a.cat ta_ni31 Josti£T_ed at the .at {saaorQiag to the Jnsican Cea fsaooi.tiaa this .qaipasat aa M p¢rc3.aa.d frm t3. T.rgasaa CmqcnT ar the TfiII CaapanF for .pprart:,tea; i3a). ` - {y) ls soaa as ths au'Sna PZ+^tEA dstazrSmctioa is rarie.3so sa to a2;aSs.C. .aT peaaitL3it7 at srraxy it is propaed ta puhlish tha totY aa the gisaaux phasa. Ya* iit.ratssrs acxz>i3aa a \0

3 taaysraVraar end a phe.a vhiaII aamists af patttalea at caliaidal siaes af acvwds thio8 aia i14aidn ar .a11GS a£ aniimt7 taayaratersa. SSxme it haz baea a3ws ia .arii.r im. •esttgattaaa that this p3.ae caaatuta prijmritf of cvFaimds' vhith are liqaids at ordtmrf taa,parstase fhi. =8ata ri2S be raferr.d to s. 'Siqaid'. . - Zu yrariaaa iaroctigatian, & ~.r at d#tfsreat etkoii hata baaa Wed to toparata }ha tm gtaaaa. Zu tSa sarY acrrtad- oat by the kmsicnn lbtaaaa Ca=2aar the aulro iaa dr4sa iata a 2arge 31aa5c amA .12arad ~ta .att2.. 6ther imnatisatars Ixisasi the emka thraagn aolTaata a+aIl aa ahlarafaza[ or thxaug4& su1lY.ritr aaid. Siace tta a<d7maEatioa srtthad appasrad to be too sics , aai the c,aa af acl7eatt iatraduaad nsr sooyrnatria Sata the gu.oas pEsa, aai aLa aae2d tarnv saro ya.teassa mt.ria7.. It ta+ d.atdat to tx7 to aapazsta the liQuiC partiaisa bf ttHag adrantags of th.ir ao3laLdai pragertis., c2eargtioa of the partiaYss an a eaAid vith a lasge surfaaa or praaipita£ioa If ai2nat a2.atria di.atarga a. ia a cattrail pna2Qitater. In sam gr.2i:inau7 espsrinca:s the rnv}a sas drssa tbrs,Egh £ubea paabi icos.7.7 Yith glaaa vaal. Yhia Eaxio" vaa aoap2.tel,f .fY.attrr but It su fauai tLat the »rl- 3s411V a+sfaea af tSt giue wool renaited ia tuah grcaavao.d adsorptiaa Etat It ss dSfSSauZt to nctr.at the tany mtsrtai aftar it Sed beea aCsoz6wt. 7brem.r it +na Cs2t ihat the gtas ieaai ras suffSaisntI7 aSkaiiat to aau.e sm ahaztca2 aheooa ia tSs tar. Ql 3z

3L =a r_:.-. . 3 a .. Zn 3atar wtpniimata :a..tl g,3xa. La21a.. auei as ar: cs.t 3a Zrsatiamtiag oa2so. rare .cr.LitN.ed far ihr gleaa roa2 rith ezts3laat ruaits. Ye ars nor ustygi Sar sath af the Zoa aig- • amtta }m2dnr.3 a P7rez gixss ta}. 3 m. a dSaastar ani 30 os. Iorg paeixd to a dapt's af Z~ c. rS'3 ?yraz &2sss Dsitoo. 3.]8 i.Mzh la dlamt.€ sah BarFaa a sire.ls tcrs. &mh a coS¢m .asiSf slaamd. iSe .:f.atiT. 151. ar saax' a colam Zs xLaat ~ afprati.a. Sas tar ia arttsatad frsa tiz* calca Ly a dztuzs 'of ehlm-ofc-a avd .ostms aoi tes ba c.all.etsC S= 3sisr aail7sta b7 Tngaratica of th. eaiT.at. .. PruaiBltaE£ac af th. aa21>`_La.t smks gsrGlcLa bF a.13.at slaotria discEarp Taa acoug:l.Ssct b) pnaa+.ag tha sstn Hizo¢gh a. a6argad S2.$ 3aah gta.a IS.hig aoadamez ,}aa'rat oaeered tn tha outaids rit9 tlnfol2 ast bari~g a o.atral lsctxroda ot IJ$ iacts sta3a=tss ataa2. Srs arLa af this sLet~ds ar, pnss~ throBgb zubDst aopp.rt aM t3s tia fa12 .rd a.atrsi slsattvdo sre attar3e5 to tIlS pols. of a'}Cw .c2t tna.iosaer cparetSug at 12 a1221uprxw. SRtr.2.iSailaa of tLs a..arda m+.hs aaYYaids.L Fartial.* aamss t3v to sega..-cts oet aa t3. .ni.L ar !kr no¢- d.aant. 2hta athoi of ..pa.-ntias 2s Tar7 .flsotiTS bat Xse t§. dlaadrea{a.gt tkat .a.o otsas ta pz.3cx.d Tytcs f2£ut azi322s aat3s aoaQoams u Iormld..Ws or tufioa zsal3.. Its wa fficrsfars sut Lo r..triatad to Rk. d.tsairatist af raah aospaan:a as azs

tobaaco mYs. 1 eopr af th3s ~s7 is sttec.'edr sita rster- saaa. 7Lis razrqr is baAag otctiFmrd mt cnl7 sm tSis tapi4 th. ars£}tical z.theds med by tariass icr.at£gntort Zar' tha datarzfratiaa ef saah earrERa3f Y siT b. .¢pest+4 ta bs praa.at In tL. ssmka. 4.sfxal c3rsetsri.tiLa of t:a saGka It bas b.s rcaxdai in snsra2 pLces ia tbe 3ltuat~ aMd eoaflzss3 b7 aiz:l* t.ata Sa wr Ma Ia'hoxsterT that tEa' prSaaips2 saafn .trsu (t3et 3r~ *3tcnas tha aigacetta) Ss $OLUIaZ1] saidiE vh$2a tb a 1tCO. iLi'j 6".OTj ttSp03 ({,,~ yt t1a glcrisyq +od af tts atbaratti batraen yaiSa} is Mis actqgssts 1mSdaataii7 tLa4 tha vcpoa.ats o1 tta .ao=ffisrfi str.e¢ aeT amkaim.irritatiag snbstaaaea nci fovai Ia t3a grin. a cipa2 str.aa. Tor the t3ae Daiug. hcrarari ismat£ast£oa is baing aaafiaed to tha priaoipal strtan. AaaIyxaa Sar tha lailor- iag ea~pacsiff Lara Lnan mdsx ia'sws caass b7 snaral nat*hDdxi WZT Wi F233 HC7. a. &+nnratfea of tbs Ca2Eaidnl ?art{glos 4f Shc Omka Rza tae Uauaovs }nesn. It £s a ve21 laae¢ faot that tobacoa m7or caoeirG af tva di.tinct pha.aat asaseona phasa vb£ah £aaled.. /aa6 eaa. yawds aa anrbos @iox£dei aarbaa }~cmt6ai LT3ro3ea salfides Saz:ze2daL~^da ar athar atarie2s vhtch asw gaascns ai o:dinarj

- . .ai. pzajsot .u .tut..d Acas 16, 1}gi5 rFta rr. Z. 3. u 7i.ha1 aa th4 ohaaist in chargs ai with Dr. S. T, FssYtm aaperriam'. St ssa auLr.toai that Yr. Iia5tS raoSd sp.ad ' . apprzib.tali hslt tias ae tktia pro,jeat aima his rEntiea Sa the fl.xvat. Sakm2 tahs up the r.st of hSs tLO.. It xis miaatao3 that t1m P. UsziIlard LUqac.F siot i-Ish to atart a s•pnzat• ia. ssatigstiaa aar.ricg tlu biolaaSOnl .ffscta af the tariaca tan- stitueaCe af tdiaaaa ta3b bat >aza dafarstaa sa.'-*. £as#:SStian' aati2 a lstar tim sinos it ss.xei logiaal to abtaiu roas aaaLFDiasl1 dnta cn tb, aonatitauE. af iha smks bafaze startia5 the othar gUas of the pmn.-raa. i3s pzr.aaC pzo3zsl tha¢ fsr -' sisaatia231r aa .-tr,.{s of the tabaaca sas2a. . ' Siaos tlv projaat hna b•sa ia fer3a for shaut +sraa aoatSa - it ssss viassLL to aYs a report u to thA pra3rras of the ia. rs.tig¢tiau. - The iasastigtina eill be caaalQazvd unLar thx+aa tnpiost (1) Pr.liaiaarr sosk vhich inalnds aaaatzvaGios af tba aahiur 33tazntara .nnsT snt dsriw. fcr apnratiqq the salid-Iitvid partial.a vEiah mks up th• Tiaffi1, part af tha aaskar fiol tha ` a gasiova pLaasr (2) TateatiPtSvn of the S+swa 7ba+•r '°i #3i Xa $.eatig.tiaa of the .a7.id-liCvid ph"+. ti0

23 tDs oas+. af this 2cst .xs.r3a.at a r81t. saiid am& axaporat.a .Ilea t!, trap is ~wt Lss : c7,nfn*---+tars axl;s uatcratd ss la shwa 17 tb. faat t5st it ri11 dscat=i:: Sxroain. iat.r. 1rS7sif of th. oasgoaa3 Is uwD.Isy mia iai It Is hap.3 ttut it oaa saca bs idsIItiflyd3 nat va3.r §sarcrue at the faLSr.rt tts ac.pv.*€. . Stself poca.uw Lut D.ascs. of tLa LeszSag i#+ xasl7ais ai32 at . asrDaa ao:r3ri3a dsts.3IIr+tSes. C. b~tcr.d=t€au af grdsecaa t5ilfi3s fat. am gaaSCr, t2J dDaazgtiom ar saroaisac2 asdaiu W1si4s r. rita p.aia.zhflr3zuYriiiue t7drxunzia. i3 ~sems ef tuzid ~a~.:aci3. to graams mthq2aa, biau. {SS.1Tticc2 s3sriatt7 of Zaiastria2 Paisossi ato. br Y.B. TacoLa}. -"ff, fint tro of tEsse s` p.~sS Ir7raatical dscav. the asoaats imois.d ara ro sa[2L. YE, tIlini a.tho3 gc» sza.2l.eC i.a.lts ah.t ,aS ty 3s ooaaiS.rad acaatt. .iaaa a.th72sn. Llcs is a suifur.aeats'"n' 4Ta sffi tLw zvaatien ia, tAenfora, sp+ait.a. fis.aits aoaordirg to this tst, shiaL is a roLa: ocqari.un tssti falla.

01146, aC Yttaqp(S yy IEA i to Sv.aTfa 2IIJ trdTNatb03i ¢SYe1II*. pf tsolud rith 114uid air .3d+t bafr,a t3' s tte abon traia. Sui+ muitri fa a aro: aid.zaLl. Csceen. in bath mtar ani carbcz diaride (hpizvge¢ acd ear5a¢ rnozid.) u is .twn br the ZoSi.Ciag ii+,fnsea. 112 teaults z.P~eseat am}aag af fi» aigarettea. ~ 's't~&~b Yt' f372 Rt`~GQ 4,ff257 ' 9.,Sm os.o;8? 0.0147 a.o6o3 0.0384 0.0180 0.05o9 o.a323 a.W92 • o.W28 a.oztz o.rRSl a.a3T7 9.L~o 0.0297 0.0402 i7.C+23b 4.CKt7b 4.Q3'i2 ' 0.0218 d.cx1:4 0.C415. B.CCO7 71rst bcbb2rr ocr.cant.-atad ass2RS3a aaidi se.oai bubbler esturate4 solnt:cc o. eilr~ :u2tets ia StS arSfSSia eaid. .'tse rarr acwida:able deazr.r.-4a4Ef amsat. of aatboa asnssfdei a. calau3ated isva oarboa dlazids Sar-.d. 3f mldattca vita aoFyer =ide, Yh.n a bssbbler acataiaiag ru7lhrie aaid (ry. ~. 1&t) aai a 2i4aid air tm are icaezted ia the eSata acgy.ets that tbe aaouat ot esTbon mrlstide in tSe swlka ia avah Z.at than ltss ia{Seated bi aar3isr ~Y as regozted ia the literatnr.. seifat+ Sa 141 sltrria naid. ' (1) Siret bnbbler sat+aata3, solutica ot e3lrar

Z1 cLvrTSzg nx$ ths det+zaiaetica the treia na firat flFUhed 12tL tEs ax]a from tns a£garsttes aftar rsicR the 7Pr£arit.s aa1 Lcatltr haib[ ta22asiag the e=hcatia train iszr •etshed. A sir.33a dstar.ai~tise :sra2ssi the malYas of fSTs aipnttsa. 8ig=:ficatt 4~titiss of mSstur+ ran tocai In the Drisrito bn2h ird4owtin3 that aw m.cporsi cantnlaln4 h7dmgtA Yaa otn2ag arss'ritti Lhe gn+. Si nSaat, of cam'aey rea3nis #ba oarbea ~azR3t de:wzaSaaLioa lnss saa:sate t'-uc It svu13 be etSanias. ' • . C67CSiti'ES.~EI YC1Y ledi aII tYU t3sN (1) that U. the 15ta2' .ru pzainsea rrsa u- 371rOg.a ara (2) that all the sat.r oa.. Sros a.thans. IIIass nFa1t: an girw In the folZoring tzbSr. 6.0352 OSCth2 4.010T 0.1257 0.0357 0.1123 0.4381 0.11,83 A.6s.6.437I a.lIlbl il. Ya . mlaiafil ool.~n{2} mlais€il(3) calair{ 1.83 1.77 2.73 1.7% 2.2] 2.11 3.32 1.0 1.31 2.90 2.98 1.82 2.0$ 2.00 3-11 1.90 1.36 1.31 2.$4 1.81 (1) ,4susiag an 823 from 82. (2) t.ssauicg all SZJ lsaa C4. 0) Y. D- .u t. 2:'a. In Ti. of t3: Sact thab acc lvsht aut ccirt v fa ths •caur%a7 at this datara[set£ca u lvqq u>$ }VirOTac Is :oau£r in ths tone of vetar, aftar faa.ing the aat crsr i3.s hwtd ocFB+w

ra us1ng ."itamiart **Mtaiain; fl.00w~ $. r2z. 20 aiv-r. #tta BtTe a TSlSt at C.OX2w 8. $G$ (aTer6fif af tYi 2Vflf.) U{14p th! i87;i itb4dII2ri, ~Q 4ip...*..es EiTa i T811ts af O.GtX)S'{S 8. &.:.. ~Sasu tntvaa aarvapard to nri5'Lt o2 0.012 silligrnz Du si5srstt. ar a xel¢+e pare.at of O.W1q}. &IH ia j the ewa}t. . , . _ $. DettlifKmtio¢ af ~!s ~ A Saatitatin tnt tar h7dragaa a7anide vsa zads b7 pass- in3 the mac2ar 3traatll aft.r th+ asgu-stSau af the liqniS j•hssit into a ami+sna;oa of Sartvv+ krLeazi3s In a+a3ntSC¢ af pataa.imc hTdre¢18s. En colazatiea ca213 be aaC3t.d on appiiaatimm ef the Yrvsai>a bZes t+ii. Siaoa thia is a taa7 esn.itiss teat it esn2d apg.ar tbat H:S in absaat In getaatabl. 4OOntiti.e. i'. IYanirsttz~ af~~' e`71Qr3S` Po~a . . 3 AaaZ7yfa ef the tar obtaiv3 117 s*=mal of the aa12a}yyl .f.o y.rtiaLa of the~rm3o requirss aawsvlaticm of agpr.afab2t '.t Quzutiti.a of the tar. Harrareri rrcn a<'t.r the tnr has b..a • • :~ oci;.atedf sspnratiaa iata 3iffsrsut ciws+u af .oastitnanta usi fira111 issto the Saiiiidns7. nsst.rs of suah aias 3s a tlas- aoaraaiag a"raticn. 2hia ySas* of th. swt7sts hss In aoae.- ; 44.aas, 1.63,4 laantar as d.finita tv.ulta era occcezs.i. c 4paratim af.th, ssYiaB sabSVS a.rried aat In oenneaticR ~ AHLk .mitaa. md. on the Ga.nus Fheas ef tbs snkv zwnlte3 in'