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r AVG ~ 2 1983 A Division of Loews Theatres, Inc., Research Center, 420 English Street, P.O. Box 21688, Greensboro, North Carolina 27420 August 17, 1983 Dr. Carol J. Henry ` Microbiological Associates 5221 River Road Bethesda, MD 20816 Dear Dr. Henry: We have the following comments and questions concerning the Draft Final Report 1-1729.005 - Six Week Repeated Smoke Inhalation in Mice to Compare Histopathology and Short-term Endpoints Using Test (D6 and D10) and Reference Cigarettes: ~~ 4ff, ~ ~ 1. Would it be possible to alter the format of the report / f ~ slightly so that the narrative is intact instead of spread throughout the report? mice/group were." On page 9, paragraph 2, line 7: the text should read "3 --,,,,3. On page 9, paragraph "mice/group were." 2, line 10: the text should read 4. On page 13, last paragraph, line 6: affect and blood are : misspelled. -\J stated that mean COHb values are significantly higher ,~ ~ instead of "different." ~a .~~ /`' _ 2- 5. In Table GT2, footnote "b" at the bottom: it should be -6. In Tables GT4-GT10: in -the, statistical data, what doe 7. On page 19, paragraph 6, line 6: pathologic is misspelled. J ~ + ; .. !. '- " "R.E.S.D." represent? ~J -t1tivGt.1t. (,e,0,7 r• 8. On page 20, line 2: results, biologically, and significant are misspelled. 9. On page 19, paragraph 2, sentence 2: the text states that X ignificant differences cannot be discerned. On the tables triglyceride levels in mice exposed to smoke from the Reference and D6 cigarettes were significantly elevated as compared to sham-exposed controls and refers to Table CCH7. Although Table CCH7 indicates that a significant difference in triglyceride levels exists, the group or groups showing

2 listed below, please indicate which groups show significant statistical differences when compared. CCHT CCH34/ CCH8,1' CCH36~ CCH9~ CCH40/ CCH2O,-" The tables, as written, are of little value to us unless they indicate/illustrate the statistical differences referred to in the text. Please make sure that the statistical methods used in the table for each parameter agree with those mentioned in the text. 11!0. On page 21, paragraph 4, line 2: the text should read "test was." 11. Same paragraph, line 4: the text should read "Changes in these." 12. On page 24, paragraph 1, line 5: Laboratory is misspelled. If you have any questions, please feel Sincerely, , Connie ~T. Stone, Ph.D., D.A.B.T. ~ CJS/jw:2 free to call.