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aneros clu Gope~aeS of o~ ndustrial Materas Sixth Edition N. IRVING SAX Assisted by: Benjamin Feiner/Joseph J. Fitzgerald/Thomas J. Haley/Elizabeth K. Weisburger VAN NOSTRAND REINHOLD COMPANY New York

Toxicity Ratings An explanation of the toxicity ratings is given in the following paragraphs: U= Unknown. This designation is given to substances which fall into one of the following categories: (a) No toxicity information could be found in the literature and none was known to the authors. (b) Limited information based on animal ex- periments was available but in the opinion of the authors this information could not be ap- plied to human exposures. In some cases this ; information is mentioned so that the reader mav ' know that some experimental work has been done. (c) Published toxicity data were felt by the authors to be of questionable validity. 0 = No Toxicity. This designation is given to materials which fall into one of the following categories: (a) Materials which cause no harm under any conditions of use. (b) Materials which produce toxic effects on humans only under the most unusual conditions or by overwhelming dosage. I = Slight Toxicity: (a) Acute Local. Materials which on single exposures lasting seconds, minutes or hours cause only slight effects on the skin or mucous membranes regardless of the extent of the exposure. (b) Acute Systemic. Materials which can be absorbed into the body by inhalation, ingestion or through the skin and which produce only slight effects following single exposures lasting seconds, tttinutes, or hours, or following inges- tion of a single dose, regardless of the quantity absorbed or the extent of exposure. (c) Chronic Local. Materials which on con- tinuous or repeated exposures extending over periods of days, months, or years cause only slight harm to the skin or mucous membranes. The extent of exposure may be great or small. (d) Chronic Systemic. Materials which can be absorbed into the body by inhalation, inges- tion or through the skin and which produce only slight effects following continuous or repeated exposures extending over days, months or years. The extent of the exposure may be great or small. In general, those substances classified as hav- ing "slight toxicity" produce changes in the human body which are readily reversible and which will disappear following termination of exposure, either with or without medical treat- ment. 2 = htoderateToxicity: (a) Acute Local. Materials which on single exposure lasting seconds, minutes or hours cause moderate effects on the skin or mucous membranes. These effects may be the result of intense exposure for a matter of seconds or moderate exposure for a matter of hours. (b) Acute Systemic. Materials which can be absorbed into the body by inhalation, ingestion , or through the skin and which produce moderate effects following single exposures lasting sec- onds, minutes or hours, or following ingestion j of a single dose. (c) Chronic Local. Materials which on con- tinuous or repeated exposures extending over periods of days, months or years cause moderate harm to the skin or mucous membranes. (d) Chronic Systemic. Materials which can be absorbed into the body by inhalation, inges- tion or through the skin and which produce moderate effects following continuous or re- peated exposures extending over periods of days. months or years. Those substances classified as having "moder- ate toxicity" may produce irreversible as well as reversible changes in the human body. These changes are not of such severity as to threaten life or produce serious permanent physical impairment. 3 = Severe Toxicity: (a) Acute Local. Materials which on single exposures lasting seconds or minutes cause in- jury to skin or mucous membranes of suflicicnt severity to threaten life or to cause permanent physical impairment or disfigurement. (b) Acute Systemic. Materials which can be absorbed into the body by inhalation, ingestion or through the skin and which can cause injury of sufficient severity to threaten life following a single exposure lasting seconds, minutes or hours, or following ingestion of a single dose. (c) Chronic Local. Materials which on con- tinuous or repeated exposures extending over periods of days, months or years can cause in- jury to skin or mucous membranes of suflicient severity to threaten life or to cause permanent impairment, disfigurement or irreversible change. (d) Chronic Systemic. Materials which can be absorbed into the body by inhalation, inges- tion or through the skin and which can cause death or serious physical impairment follou ing continuous or repeated exposures to small amounts extending over periods of days, months or years. W U9 ~ ~ ~ N ~ OD i

t KEY TO ABBREVIATIONS (Refer to Introduction for Elaboration of Certain Definitions) ~ ~ alc-alcohol ALR-allergenic effects AQT'X-Aquatic Toxicity ,sn-Aspergillus nidulans BCM-blood clotting mechanism effects bcs-Bacillus subtilis BLD-blood effects bmr-bone marrow BPR-blood pressure effects brd-bird (domestic or lab) bwd-wild bird species C-continuous CARC-carcinogenic effects cc-cubic centimeter chd-child ckn-chicken CL-ceiling concentration CNS-central nervous system effects compds-compounds crys-crystal CUM-cumulative effects CVS-cardiovascular effects cyt-cytogenetic analysis D-day dck-duck DDP-drug dependence effects dec-decomposes DEF-definition dit-dominant lethal test dmg-Drosophila melanogaster dnd-DNA damage dnr-DNA repair dns-unscheduled DNA synthesis dom-domestic DOT-Department of Transportation dpo-Drosophila pseudo-obscura emb-embryo EPA-Environmental Protection Agency esc-Escherichia coli ETA-equivocal tumorigenic agent eye-administration into eye (irritant) EYE-eye effects (systemic) lbr-fibroblast frg-frog g. gm-gram GIT-gastrointestinal tract effects GLTr-glandular effects gpg-guinea pig ~. grb-gerbil li. hr-hour h:,m-hamster hl-}ieLa cell hma-host-mediated assay hinn-human 1-mtrrmittent W-mt raaural IARC-International Agency for Research on Cancer iat-intraarterial ice-intracerebral icv-intracervical idr-intradermal idu-intraduodenal ihl-inhalation imm-immersion imp-implant ims-intramuscular inf-infant ipc-intraplacental ipl-intrapleural ipr-intraperitoneal IRDS-primary irritation dose im-intrarenal IRR-irritant effects (systemic) isp-intraspinal itr-intratracheal ivg-intravaginal ivn-intravenous kg-kilogram (one thousand grams) klp-Klebsiella pneumoniae L-liter LC50-lethal concentration 50 percent kill LCLo-lowest published lethal concentration LD50-lethal dose 50 percent kill LDLo-lowest published lethal dose leu-leukocyte Iel-low explosive limit uel-upper explosive limit Ing-lung lvr-liver lym-lymphocyte M-minute(s) M3, m3-cubic meter(s) mam-mammal (species unspecified) metn-membrane u, µ-micron mg-milligram (one thousandth of a gram;10-3 gram) misc-miscible mky-monkey mi-milliliter MLD-miid irritation effects mm-millimeters mma-microsomal mutagenicity assay MMI-mucous membrane effects mmo-mutation in microorganisms mmol-millimole mmr-mammary gland mnt-micronucleus test MOD-moderate irritation effects mol-mole mppcf-million particles per cubic foot mrc-gene conversion and mitotic recombination msc-mutation in somatic mammalian cells 69

Ver. 2 Currently Tested by NTP for Carcinogenesis by Standard Bioassay Protocol as of December 1980. THR: MUT data. An exper CARC. MOD orl. Disaster Hazard.• When heated to decomp it emits acrid smoke. h2-PROPANEDIAMINE CAS RN: 78900 NIOSH #: TX 6650000 mf: C3HIONs; mw: 74.15 Flash p: 92°F (OC), d: 0.9, vap. d: 2.6, bp: 118.9°. SYNS: 1,2.D1AMiNOPROPANE PROPYLENE DIAMINE (DOT) TOXICITY DATA: 2 CODEN: skn-rbt 1 mg/24H AMIHBC 10,61,54 skn-rbt 435 mg open SEV UCDS•• 3/12/69 eye-rbt 87 mg SEV UCDS" 3/12/69 orl-rat LD50:2230 mg/kg UCDS•' 3/12/69 scu-rat LDLo:2250 mg/kg ZEPTAT 17,59,15 skn-rbt LD50:500 mg/kg AMIHBC 10,61,54 Aquatic Toxicity Rating: TLm96:100-10 ppm WQCHM• 4,-,74. DOT: Flammable Liquid, Label: Flammable Liquid FEREAC 41,57018,76. Reported in EPA TSCA Inventory, 1980. THR: A skn, eye irr. MOD skn, orl. Fire Hazard: Dangerous, via heat, flames, oxidizers. To Fight Fire: Alcohol foam. Disaster Hazard: When heated to decomp it emits tox fumes of NOr. 1,3-PROPANEDIAMINE CAS RN: 109762 NIOSH #: TX 6825000 mf: CaH1oNZ; mw: 74.15 Water white liquid, amine odor, completely sol in water, methanol and ether. d: 0.8881 @ 20°/20°, bp: 139.7°, fp: -12°, flash p: 120°F (TOC). SYNS: 1,3-DIAMINOPROPANE TRIMETHYLENEDIAMINE 1.3-PROPYLENEDIAMIN E TOXICITY DATA: 3-2 CODEN: skn-rbt 50 mg open SEV UCDS•• 1/28/63 eye-rbt I mg SEV UCDS** 1/28/63 orl-rat LD50-350 mg/kg AIHAAP 23,95,62 orl-rat LD50:500 mg/kg 37ASAA 7,580,79 skn-rbt LD50:200 mg/kg AIHAAP 23,95,62 Reported in EPA TSCA Inventory, 1980. THR: MOD orl. HIGH orl and dermal tox. A skn, eye irr. Fire Hazard: MOD, when exposed to heat or flame. Disaster Haiard: When heated to decomp it emits tox fumes of PO=. PROPANE. DIISOTHIOUREA DIHYDROBROMIDE CAS RN: 5442320 NIOSH #: UO 1320000 mf: CsH1zN4S2•2BrH; mw: 354.17 SYN: 2,2'-TRIMETHYLENE-BtS{2-THIOPSEUDOUREA), DIHYDRO- BROMIDE 1.2-PROPANEDIOL 2293 TOXICITY DATA: 3 CODEN: ipr-mus LD50:250 mg/kg NTIS** AD691r490 unk-mus LDLO:200 mg/kg ATMPA2 32,177,38 Reported in EPA TSCA Inventory, 1980. THR: HIGH ipr, unk. Disaster Hazard: When heated to decomp it emits very tox fumes of HBr, SO= and NO=. 1,2-PROPANEDIOL CAS RN: 57556 NIOSH #: TY 2000000 mf: C3HBOz; mw: 76.11 Colorless liquid,. practically odorless, hygroscopic. bp: 188.2°, flash p: 210°F (OC), lel = 2.6%, uel = 12.6%, d: 1.0362 @ 25°/25°, autoign. temp.: 700°F, vap. press: 0.08 mm @ 20°, vap. d: 2.62, fp: -59°. SYNS: 1,2-DIHYDROXYPROPANE PROPYLENE GLYCOL METHYLETHYLENE GLYCOL ALPHA-PROPYLENEGLYCOL MONOPROPYLENE GLYCOL 1,2-PROPYLENE GLYCOL PROPANE-1,2-DIOL TRIMETHYL GLYCOL TOXICITY DATA: 3-2-1 ipr-mus TDLo: 100 mg/kg (1ID preg) ipr-mus TDLo: 100 mg/kg (15D preg) skn-mus TDLo * 17600 mg/kg/2Y- UETA skn-hmn 500 mg/7D MLD skn-hmn 104 mg/3D-I MOD skn-man I0%/2D eye-rbt 104 mg eye-rbt 500 mg/24H MOD orkhd TDLo:79 gm/kg/56W-I:CNS orl-rat LD50:20 gm/kg ipr-rat LD50:13 gm/kg scu-rat LD50:28 gm/kg ivn-rat LD50:6800 mg/kg ims-rat LD50:20 gm/kg orl-mus LD50:24 gm/kg ipr-mus LD50:11400 mg/kg scu-mus LD50:18500 mg/kg ivn-mus LD50 : 8000 mg/kg orl-dog LD50:22 gm/kg ivn-dog LD50:26 gm/kg orl-rbt LDLo*20 gm/kg skn-rbt LD50:20800 mg/kg ivn-rbt LDLo:4200 mg/kg ims-rbt LDLo:6300 mg/kg orl-gpg LD50 * 19 gm/kg scu-gpg LDLo: 15500 mg/kg ivn-ckn LDLo :27 gm/kg CODEN: KAIZAN 37,239,62 KAIZAN 37,239,62 TXAPA9 30,7,74 JIDEAE 55,190,70 85DKA8 -,127,77 JIDEAE 19,423,52 JPETAB 82,377,44 28ZPAK -,37,72 JOPDAB 93,515,78 TXAPA9 45,362,78 JIHTAB 31,256,49 JIHTAB 31,256,49 NTIS** PB280-477 JIHTAB 31,256,49 JIHTAB 21,173,39 TXAPA9 1,576,59 JPETAB 65,89,39 JPETAB 65,89,39 JIHTAB 21,173,39 NTIS** PB280-477 NTIS** PB280-477 NPIR10 1,101,74 JPETAB 44,109,32 JPETAB 44,109,32 JIHTAB 21,173,39 NTIS** PB280-477 JPETAB 60,312,37 Aquatic Toxicity Rating: TLm96 :over 1000 ppm WQCHM* 4,-,74. Toxicology Review• AJMEAZ 38,409,65. Reported in EPA TSCA Inventory, 1980. EPA TSCA 8(a) Preliminary Assessment Information Proposed Rule. EPA TSCA 8E No: 01780041-Fol- lowup Sent as of April, 1979. THR: A skn, eye irr. A hmn CNS. LOW orl, ipr, scu, iins, skn. Used' as an emulsifying agent and a general- purpose food additive. It is a substance which migrates to food from packaging materials. Fire Hazard: Low, when exposed to heat or flame; can react with oxidizing materials. Spontaneous Heating: No. 88698210

1 2294 1,3-PROPANEDIOL Explosion Hazard: Mod, when exposed to flame. To Fight Fire: Alcohol foam. 1,3-PROPANEDIOL CAS RN: 504632 NIOSH #: TY 2010000 mf: C3H802; mw: 76.11 Colorless, odorless liquid, sol in water, alcohol and ether. d: 1.0536 @ 25°, bp: 210°-211°, vap. d: 2.6, autoign. temp.: 752°F. SYNS: 2-DEOXYGLYCEROL 1,3-PROPYLENE GLYCOL 1,3-DIHYDROXYPROPANE TRIMETHYLENE GLYCOL BETA-PROPYLENE GLYCOL TOXICITY DATA: 1 CODEN: orl-mus LD50:4773 mg/kg TXAPA9 49,385,79 Reported in EPA TSCA Inventory, 1980. THR: LOW orl. See also glycols. Disaster Hazard.• When heated to decomp it emits acrid smoke and fumes. PROPANETHIOL CAS RN: 107039 NIOSH #: TZ 7300000 mf: C3HeS; mw: 76.17 Flash p: -4°F. SYNS: 3-MERCAPTOPROPANOL PROPANE-I-THIOL PROPYL MERCAPTAN N-PROPYL MERCAPTAN TOXICITY DATA: 2 CODEN: eye-rbt 83 mg SEV AIHAAP 19,171,58 orl-rat LD50: 1790 mg/kg AIHAAP 19,171,58 ihi-rat LC50:7300 ppm/4H AIHAAP 19,171,58 ipr-rat LD50:515 mg/kg AIHAAP 19,171,58 ihl-mus LC50:4010 ppm/4H AIHAAP 19,171,58 TOXICITY DATA: 2 CODEN: ivn-hmn TDLo: 5 mg/kg: BPR BJANAD 45,1097,73 orl-rat LD50:700 mg/kg TXAPA9 18,185,71 THR: A hmn BPR. MOD orl. Disaster Hazard.• When heated to decomp it emits tox fumes of NOr. 3-PROPANOLAMINE CAS RN: 156876 NIOSH #: UA 5600000 mf: C3H9NO; mw: 75.13 Colorless liquid, fishy odor. bp: 168° @ 500 mm, flash p: >175°F (TOC), fp: 12.4°, d: 0.9786 @ 30°, vap. press: 2.1 mm @ 60°, vap. d: 2.59. Very sol in water, sol in alc; insol in ether. SYNS: BETA-ALANINOL GAMMA-AMINOPROPANOL 3-AMINOPROPANOL 3-AMINO-1-PROPANOL TOXICITY DATA: 3-2 skn-rbt 10 mg/24H open SEV ipr-mus TDLo:5700 ug/kg (11D preg) orl-rat LDLo:2830 mg/kg skn-rbt LD50:1250 mg/kg 3-AMINOPROPYL ALCOHOL 3-HYDROXYPROPYLAMINE PROPANOLAMINE 1,3-PROPANOLAMINE CODEN: AIHAAP 23,95,62 TJADAB 4,141,71 AIHAAP 23,95,62 AIHAAP 23,95,62 Reported in EPA TSCA Inventory, 1980. THR: MOD via dermal and oral routes. See also amines. A mod strong base which, from animal exper, would seem to be a non-specific irr. Fire Hazard: Mod, when exposed to heat or flame; can react with oxidizing materials. To Fight Fire: Foam, C02, dry chemical. Disaster Hazard.• When heated to decomp it emits t0x fumes of NO=. DOT Fl bl Li id L b l Fl bl Li id : amma e qu , a : amma e e qu FEREAC 41,57018,76. Occupational Exposure to PROPANOLOL GLYCOL CAS RN: 36112955 NIOSH #: TZ 0800000 n-Alkane Mono Thiols recm std: Air: CL 0.5 ppm/ 15M NTIS**. Reported in EPA TSCA Inventory, mf: C13HuOs; mw: 218.27 1980. SYNS: THR: MOD orl, ihl, ipr. An eye irr. Violent reaction with Ca(OCI)2. Very dangerous fire hazard. I-(2,3-DI HY DROXY PROPOX Y) 3-(ALPHA-NAPHTHOXY} 1,2-PB0Y NAPHTHALENE PANEDIOL Disaster Hazard.• When heated to decomp it emits tox fumes of SO=. TOXICITY DATA: 3-2 orl-mus LD50 :6900 mg/kg CODEN: JMCMAR 7,167,64 scu-mus LD50:828 mg/kg JPETAB 93,470,48 PROPANE-2-THIOL ivn-mus LD50:88 mg/kg JPETAB 188,86,74 mf: C,HeS; mw: 76.16 Flash p: -31°F. THR: HIGH ivn; MOD scu, orl. Disaster Hazard: When heated to decomp it emits acrid smoke and fumes. THR: No tox data. A very dangerous fire hazard. Disaster Hazard: When heated to decomp it emits tox 3-PROPANOLPYRIDINE fumes of SOr. CAS RN: 2859678 NIOSH #: UT 7390000 PROPANIDIDE mf: CeH11NO; mw: 137.20 GD CAS RN: 1421143 NIOSH #: AG 9625000 TOXICITY DATA: 3 CODEN: p~ mf: C18HnNOs; mw: 337.46 SYNS: BAYER 1420 PROPANTAN ivn-mus LD50:180 mg/kg CSLNX- NX#01584 ~ Reported in EPA TSCA Inventory, 1980. W QD THR: HIGH ivn. ~N ~

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