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HhAZARDOUS SUBSTANCES DATABANk: NUMBER LAST REVISION DATE RECORD LENGTH NAME OF SUBSTANCE CAS REG I STRY NUMBER SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS :.aY NONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS MOLECULAR FORMULA WISWESSER LINE NOTATION Rr%TECS NUMBER OF-IM-TADS NUMBER METHODS OF MANUFACTURING MANUFACTURERS MANUFACTUF;ERS MANUFACTUREf;S MANUFACTURERS MANUFACTURERS MANUFACTURERS MAJOR USES CONSUMF'T I ON F'ATTERNS 174 85o528 13370 PROPYLENE GLYCOL 57-55-6 1,2-DIHYDROXYF'ROPANE 1,2-F'ROPANEDIOL 1 , 2-F'ROF'YLENE GLYCOL 2,:'•.-F'ROPANEDIDL .4-HYDF;OXYF'ROPANOL ALPHA-PROPYLENE GLYCOL METHYL GLYCOL METHYLETHYL GLYCOL METHYLETHYLENE GLYCOL MONOF'F<OF'YLENE GLYCOL PG 12 PFtOPANE-1,2-DIOL SIRLENE TRIMETHYL GLYCOL C3-H8-02 OY1c? N I OSH/TY?cjocjcjcj0 7216877 HYDRATION OF PROPYLENE OXIDE [SRI] CELANESE CORP, CELANESE CHEM C0, DIV, BISHOP, TEX [SRI] DOW CHEM USA q FREEF'ORT, TEX, F'LAL?UEM I NE , LA [SRI] JEFFERSON CHEM COq INC, PORT NECHLSq TEX CSRI ] OLIN COF:F', DESIGNED PRODUCTS DIV, BRANDENBUFiG, F~:Y [SFt I] OXIRANE CHEM CO, BAYPORT, TEX [SRI] UNION CARBIDE CORP, CHEMS AND PLASTICS DIV, INSTITUTE AND SOUTH CHARLESTON, W VA [SRI] CHEMICAL INTERMEDIATE IN SYNTH OF POLYESTER RESINS; COMMODITY FOR EXPORT; COMPONENT OF CELLOPHANE C SR I ] 52'l. FOR POLYESTER RESINS; 11'l. EXF'OrTED ( 1973) ; 3. 5'l. FOR CELLOPHANE; 7. 5: AS A TOBACCO HUMECTANT; 7'/, FOR SYNTHESIS OF {'OLYMERIC F'LASTICIZESiS: 47. AS A COMPONENT OF BRAKE iiND OTHER FUNCTIONAL FLUIDS; 10% FOR M I SC AF't='L I CAT I ON:3 ( 197:' )"BR I] U.S. PRODUCTION ( 1 r'7^) 2. i3(i:`I0-1-11 GRAMS [Si-:I ] U. S. PhODUCTION (1"-i75) 1.7'7Xi()+11 GRAMS [SRI] U. S. IMF'nRTS (197._) ND [:aRI ] GO U. S. :[M1='O hTIS (1975) ND CSRI ] 0D U.S. EXF'nr;T5 (197'2) 4.90X10-;-10 GRAMS CSR I' ~ U. S. ~t =Xr='O ;TS (1976) 2.91X1o+10 URAMS [SF:I ] GD ~ A

MOLECULAR WEIGHT DENSITY/SPECIFIC GRAVITY HEAT OF COMBUSTION HEAT OF VAPORIZATION SOLUBILITIES SPECTRAL PF;OF'ERT I ES SURFACE TENSION VAPOR PRESSURE V I SCOS I T Y OTHER CHEMICAL/PHYSICAL PROPERTIES OTHER CHEMICAL/PHYSICAL F'ROF 'ERT I ES OTHER CHEM I i,AL/F'HYSICAL FROF'ERT I ES OTHEF: CHEP1 I CAL /F'HYS I CAL F'F:OF'ERT I E::~ FIRE F'OTENTIAL FLASH F'O I NT AUTO I GPd I T I 7N TEMF'EFrir+TUf:E F I RE F I GHT I NG PROCEDURES EXFLOSI VE LII`1I T S AND POTEhaT :(;'1 L COLORLESS VISCOUS LIQUID [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 19771 PRACTICALLY ODORLESS [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977] PRACTICALLY TASTELESS [HAWLEY. CONDENSED CHEM DICTNF,Y 9TH ED 1977] 189 DEG C CWEAST. HDBK CHEM & PHYS 60TH ED 19791 76.11 CWEAST. HDBK CHEM & PHYS 60TH ED 19793 1.0361 @ 20 DEG C/4 DEG C CWEAST. HDBK CHEM & PHYS 60TH ED 19791 431.U KG CAL/MOLE [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 19773 168.6 CAL/G @ BP [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 19771 SOL I N ALL i ROF'ORT I ONS I N WATER & ALCOHOL, SOL IN ETHER & BENZENE CWEAST. HDBK CHEM & PHYS 60TH ED 19791 INDEX OF REFRACTION: 1.4T?4 @ 20 DEG C/D; SADTLER REFERENCE NUMBER: 267 ( I R, FR I SM ); 92 (IR, GRATING); 45 (NMR, VARIAN) [WEAST. HDB}•: CHEM & PHYS 60TH ED 19791 40.1 DYNES/CM @ 25 DEG C [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 19771 0.07 MM HG AT 20 DEG C [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977] 0. 581 F'O I SE @ 20 DEG C C HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977] SLIGHTLY ACRID TASTE; DENSITY 1.036 @?5 DEG C/4 DEG C,, FREEZES @ -59 DE G C; FF' 108.2 DEG C@ 760 MM HG /DL-FORM/ CMERCk: INDEX 9TH 'ED 1976] OPTICAL ROTATION: -15. C DEG @ '2U DEG L./D; BOILING F'OINT 187-139 DE^u C C 760 MM HG /L-FOnM/ CMEFtCk~: INDEX 9TH ED 1976] M I SC I BLE W I TH WATEFC, ACETONE, CHLOF:OFOFiM ; SOL IN ETHER; IMMISCIBLE WITH FIXED OILS /DL--FORM/ CME;ClKINDEX 9TH ED 1976] SPECIFIC HEAT: 0.1590 CAL/G Cd 210 DEG C; HYGROSCOPIC CHAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977] LOW /FIF:E HAZARD/ WHEN EXPOSED TO HEAT OR FLAME; CAN REACT !4I TH O X I D I Z I NG MATEF' I ALS . C SAX . DANGER F' :OF'S I NDUS MATER 5TH ED 19791 210 DEG F f1C C HAWL_EY . CONDEP ISED CHEM D I CTIVF;Y 9TH ED 1977] 700 DEG F CSAX. DANGER r F,OF'S I h:ID.JS MATER 5TH ED 19791 /U SE/ ALCi1f-41r_1L FOAM. C ~JA X. DANGER PROPS I i14DUS MATER 5TH S=T_; 1~~79] UPPER 12). 6'.`., LOWER 2. 6%. MODERATE /EXF'LOSION HAZA RD/ WHEN E:XPOSELD TO FLAME. CSAX. DANGER PROPS INDUS MATER 5TH ED 19791 88698165

`.=hi r r: 'M~=NT METHODS AND SH I F'F' I Nt.:, CONTA I NEF;S :GLA SS BOTTLES; DRUMS; F;ErIJLATIONS TANk; CARS; TANK TRUCKS. [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977] STABILITYlSHELF LIFE CAN REACT WITH OXIDIZING MATERIALS [SAX. DANGER F'i~;OF'S INDUS MATER 5TH ED 1979] :STABILITY/SHELF LIFE STABLE UNDER ORDINARY CONDITIONS, TENDS TO OXIDIZE AT HIGH TEMP [MERCK INDEX 9TH ED 19767 TOXIC HAZARD RATING 1. TOXICITY IS SAID TO BE SIMILAR TO THAT OF GLYCERI NE & I S THEREFORE PRACT I CALLY NONTOXIC. NO UNTOWARD REACTIONS DESCRIBED IN MAN... 1= F'"-:ACT I CALLY NONTOX I C: PROBABLE ORAL LETHAL DOSE (HUMAN) IS ABOVE 15 G/k:G; FOR 7o Ec:G PERSON (150 LB), MORE THAN 1 QT (2.2 LB). CGOSSELIN. CTCF' 4TH ED 1976] I SON I Ni3 POTENT I AL F'ROi='YLENE GLYCOL... f='hESENTS ESSENT I ALLY NO TOXICITY HAZARD. CENCYC OCCUPAT HEALTH & SAFETY 1971] =~NT I DOTE AND Ei IEFiGEhlCY TREAT F'T, NOT THE F'D I SON I S MOST SUCCESSFUL i nEATMENT GENERAL FtULE... /NON-TOXIC INGESTION/ C FiUMACk::. F'O I S I NDEX 1975-F'F{ESENT ] i-11i JMAN TO X I C I TY E.XCEFiF'T S F'ROF'YLEhIE GLYCOL MAY CAUSE HEMOrLOB I NUR I C NEPHROSIS. CTHIENES. CLIN TOX 5TH ED 197.2] HUMAN TOXICITY EXCERPTS t-IUMAN... HAVE BEEN EXPOSED TO SATURATED AND SUPERSATURATED ATMOSPHERES FOR PROLONGED F'ERIODS... WITt-1OUT ADVERSE EFFECTS. ... EYE CONTACT...[-iAS NOT C;AUSED ANY EYE Ir~F{ITATION... NO[~{ WOULD SUCH BE EXPECTED. CF'ATTY. IilDUc; HYG & "lOX 2ND ED VOL") 196'] HUMAN i;?::ICIT'{ ` Ar_i_F\I'°I S ALTHi ~UGH NOhd:[N~URIOUS, A DROP '' APPLIED TO HUMAN EYE CAUSES I MMED I ATE ST I idG I NG, ~'-~LEF'HAROSF'Fi SM & LACRI MAT I ON. .. D I SCOMFORT LASTS FOR SEVERAL SEC UNTIL TEARS WASH...AWAY. THIS IS FOLLOWED BY MILD fFtANSIF_NT COiVJUNCTIVAL HYF'EREMIA, L:UT NO RESIDUAL i:)ISCOi'•IFOF:T Of INJURY. CG,ANT. TOX t.aF Ti-I_ F YE 1 r7ti ] HUMAN TO\ICI-f`,' EXCERPTS ORALLY ADMIN PROPYLENE GLYCOL (1-1.5 G/F::G) HAS REDUCED :i!`dTRAOCULAF: F'FiESSURE... BY kA I'S I i`dr GISMCT I C F'RESSU ;E OF E{LOOD. .. I N HUMAi`d... EG.ANT. TOX OF THE EYE 1974 ] HUMAN TOXICITY EXCERPTS FROM IR'ESULTS Ot=...366 HUMAN SUBJECTS WITH VAF.I OUS DERMATOLOG I CAL E'•ACKGROUNDS,[ T HPF 'EARS :i-IAT PROPYLENE GLYCOL MAY CAUSE PRIMARY S t::::[t•d IF:RITATIOIN IN SOME F'EDF'L1-_, ;'F~ti7r;A?~~i_Y 1;iJE ~_0 DEHYDRATION, BUT MATEr,IAL DOES NOT r.aF'F=EAFt TO BE SENSITIZER. [F'ATTY. INDUS 14 YGi :?< •i 0 ?hJD ED VOL2 196'] i iUMrthd TuX 1=C I TY I:::XCEFiF'T:; .../:[ T i TO HAVE SEDAT 1'vE-TYF'E OF 3:=FFE~~"f v I':1 YC3G"•~hlIC. .. C1='ATT'!. INDU•:~ i IY~~ & L.0 r ~t•ID IED VOL2 1V6':] Gp Cz T CD GO N ~ ~

=4UMt~N TOXI_;ITY EXCI=R. P T S UNDIL PROPYLENE GLYCOL TESTED ON Sk::IN OF MAN PRODUCED NO I F~iFt I TAT I ON UNDER OPEN CONDITIONS. OCCLUSIVE CONDITIONS F'RODUCF_D SEVERE RESPONSE WITH ERYTHEMA, EDEMA °< VESICLES. REPEATED EXPOSURE TO 10 & 30% FOF': 2 WF; SUGGESTED FZEACT I ONS DUE TO SWEAT hETENTION & WEAK PRIMARY IRRITATION. CMOTOYOSHI K ET AL; J SCCJ 13: 29-39 (1979) ] NON-•Ht!MAN TOX I C I TY W I TH LETHAL DOSAGE M I CE D I ED W I TH DYSPNEA EXCERPTS AND CRAMPS. ...LOSS OF EQUILIBRIUM, DEPRESSION, ANALGESIA, FINALLY DEATH AFTER PROLONGED MORIBUND STATE. CE.FtOWNING. TOX & METAB INDUS SOLV 1965] NON-HUMAN TOXICITY ...IV INJECTION OF 1-10 ML IN RATS PROVOKED EXCERPTS A TRANSITORY FALL IN BLOOD F'RESSUF"E...0. t5-0. 3 h9L/k::G WERE FOLLOWED BY TRANSITORY DIURESIS. [BROWNING. TOX & METAB INDUS SOLV 1965] NON-HUMAN 'TOXICITY ACUTE: SLIGHT DEGENERATIVE CHANGES IN EXCERPTS KIDNEYS OF DOGS RECEIVING LARGE IV AND DIVIDE D GASTRIC DOSES... CBFtOWNING. TOX & METAB INDUS SOLV 1965:! NON--HUMAN TOXICITY WHEN TESTED BY APF'LICATION TO RABBIT EYES EXCERPTS IT...CAUSED NO MORE THAN TRANSIENT SLIGHT CONJUNCT I VAL HYF'Er EM I A. TESTS ON F:ABBI T EYES FROM WH I CH CORNEAL Er''ITHELIUM.. . nEMOVED.. . /SHOWED/ NO INJURY FROM IRRIGATION WITH S0"l. SOLN IN WATER FOR 5 MIN, BUT MODERATE REACTION TO...UNDILUTED F'nOF'YLENE GLYCOL FOR 5 MIN. CGF:ANT. TOX OF THE EYE 1974] NON-HUMAN TOXICITY INJECTION INTO VORTEX VEIN OF ANIMAL EYES EXCERFTS (0.25 ML IN 10 SEC) ... CAUSED SPORADICALLY SL I GHT SEROUS DETACHMENT 0= r:ET I PaA & SEPAF;A'T I ON OF NONF' I GMENTED FROM F I t_,MENTED EF'ITHELIUM OF CILIARY BODY, BUT NO DEGENERATION OF RETINA & NO CYSTOID CHANGES IN F'AI;S f~LANA OF CILIAFtY BODY. [GRANT. TOX OF THE EYE 3.9743 NON-HUMAN TOXICITY ORALLY ADMIN PRr>f='YLENE GLYCOL (1-1.5 EXCERPTS G/F::G) ... REDUCED INTRAOCULAR PRESSURE IN f::ABBI TS BY FtA I S I NG OSMOT I C PhES SU11E OF BLOOD... [GRANT. TOX OF THE EYE 1974] NON-HUMAN TOX I C I TY 2.3 L OF PROPYLENE GLYCOL G I VEN TO A HORSE EXCERPTS IN MISTA4"E FOR MINERAL OIL. CAUSED DEF'l-_~C_"SSION & ATAXIiy, W:[TI_{ l_l:EC=lVi-_.__FtY IN = DAYS. 7.5 L WAS LETHFiL... /WHEN/ FED TO DOGS AT RATE OF `? G/k::C]/:GraY FOR .; Y1=i T HAD NO ILL E:; "FECT-S. C CLAF:r<:E<'JET TO X 1^7=; ] 8869816'7

NON-HUMAN '1"O X I C I TY ... STUD I ES DEMONSTRATED THAT RAT CAN E X CEF{F'TS TOLERATE 1 c';`l.. .. I N DF; I NKI NG WATER W I TfAlOUT F'HYS I OLOG I C I MF'A I FiMENT .... MOhdk:EYS & RATS /EXPOSED/ TO ATMOSPHERES SATURATED WITH PROPYLENE GLYCOL VAFOR.. . /E)(F'EnIENCED/ NO ADVERSE EFFECTS...AFTER PERIODS OF 12-18 MO. CCASARETT. TOXICOLOGY 1975] NON-HUMAN TOXICITY ...i;ATS /FED/ 2.45 & 4.9%...IN DIET...AVG EXCERPTS DAILY INTAKES OF 0.9 TO 1.77 ML/KG OVER 24 MO.../SHDWED/ NO SIGNIFICANT EFFECT ON GROWTH RATE. MICROSCOPIC EXAM OF TISSUE REVEALED VERY SLIGHT LIVER DAMAGE, BUT NO RENAL PATHOLOGY. .../30% IN DIET/ NOT WELL TOLERATED BY YOUNG RATS & PRODUCING FEMALES...UNABLE TO.../WEAN YOUNG/. [PATTY. INDUS HYG & TOX 2ND ED VOL2 19b'] NON-HUMAN TOXICITY TOPICALLY, IT APPEARS TO BE WELL TOLERATED E*XCERF'TS I N t-I I GH CONCN ON Sk:. I N, EYE °< MUCOUS MEMBRANES OF MANY AN I MALS, ALTHOUGH I T F'FiODUCES PART OF F'A I N OR ST I NG SENSAT I ONS NOTED W I TH I TS M I XTUFiES ON I M OR WOUND THERAPY. PARENTERALLY HIGH DOSES PRODUCE TF;ANGIU I L I-Z I NG OR DCF'RES SANT ACT I ON. ... I V USE FOR SHEEF'...F'RODUCES HEMOGLDEsINURIA. EROSSOFF. HDBk: VET DRUGS 1974] '•ION-HUMAN TOX I C I TY ORAL ADM I N OF PROPYLENE GLYCOL TO RATS ( 1 ML ~~ EXCERPTS OF 9CJX/1C?() G BODY W.T/7 DAYS) DID NOT AFFECT HEF'AT I C M I CROSOMAL CYTOCROME P450 CC7NTENT, BUT STIMULATED ANILINE H`(DFiOXYLA`33E & SL I LHTLY INCR CYTOCHF;OME B5 CONTENT & BROMOSULFOF'HTt-IALE I N-"F; I ND I NG CAF'AC I TY OF CYTOSOL Z FRACTION. CAMA"IOTO T, ADACHI Y; GASTROENTEROL JF'hd 13:~59 (1978)l NON-HUMAN TOX I C I TY PROPYLENE GLYCOL ( 90% ) PRODUCED CONDUCT I VE E XCEF:FTS M I DDLE EAR PROBLEMS I N GU I NEA P I GS D! IT THERE WAS NO LOSS OF HAIR CELLS ABOVE THAT FOUND IN NORMAL UNTREATED ANIMALS. [VERNON J ET AL ; ARCH OTOLARYNGOL 1(--)4 : 726 (1978,11 NON-HUMAN TOX I C I TY I F' ADM I N OF 0.1 ML r'ROF'YLENE GLYCOL TO M I CE EXCERPTS CAUSED CHROMOSOMAL ABERRATIONS IN SPERMATOCYTES. rlF:AZVI F ET AL; AROGYA (MANIPAL, INDIA) °',: bt5-2 t 1979) ] NON-HUMAN TUX I C I TY I N CALVES I V I NJECT I ON OF A6? F'F:EI='N OF EXCERPTS OXYTETRACYCL:I:NE--HCL IN PROPYLENE GLYCOL & (=F";OrYLEI~IE ~_3LYCnL 6?L-~JNE ;=~I~.ODUCEt~ ~ODUCEt~~ TI-;Ar•dC]I`NT (1--•4 MIN) f'E'_F.ID1~S OF CraRDIOVi-HSC1_JL'iR DEPRESSION CHAhACTEf~~IZED BY CARDIA C. ASYSTOLE, SYSTc:M I C F-IYF'C]TENS I ON & DCi_R PULMONARY & I-_:ENr-1L t-a:TEIRIAL BLOOD C=I_CW. ~ C GROSS DR ET riL q NM J":'!=T RES -}s i; (197 9) ] ~ ~ 0) (2)

NON--F-fUMAid TOX I C I TY UND I LUTED PROPYLENE GLYCOL TES T ED ON Sf%:I NS ~XCE'r-tF'TS OF RABBIT, GUINEA F'IG & MINATURE SWINE PRODUCED NO I FtR I TAT I ON RESPONSE ON NORMAL SKI NS US I NG OCCLUS I VE & OPEN TECHN I L?UE S. HUMAN TOXICITY VALUES CMOTOYOSHI K ET AL; J SCCJ 13: 29-T9 I F":R I TANT DOSE HUMAN DERMAL 104 MG/ 3 INTERMITTENT; TOXIC EFFECT: MODERATE (1979)] DAYS SKIN ON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES IRRITATION; TDLO CHILD ORAL 91 MG/t'G/56 WK; TOXIC EFFECT: CNS EFFECTS. INIOSH. REG TOX EFFECT CHEM SUB 1978] LD50 RATS ORAL 21 G/K.G INIOSH. REG TOX EFFECT CHEM SUB 1977] LD5D RATS INTRAPERITONEAL 13 G/E<:G ENIOSH. REG TOX EFFECT CHEM SUB 19777 LD50 RATS SUBCUTANEOUS 23 G/k-:G NON-HUMAN TOX I C I TY VALIJE S INIOSH. REG TOX EFFECT LDSc i RATS I NTRAMI_ISC ULAF' C N I OSH . REG TOX EFFECT CHEM SUB 1977] 2"o G/KG CHEM SUB 19771 NON-HUMAN TO X I C: I TY VALUES IuON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES LD50 MICE SUBCUTANEOUS 18500 MG/f~:G ENIOSH. REG TOX EFFECT CHEM SUB 1977] LD50 MICE ORAL 24 G/k:G CNIDSH. REG TOX EFFECT CHEM SUB 1977] LD50 MICE INTRAPERITONEAL 11400 ENIOSH. REG TOX EFFECT CHEM SUB 1977] NON-HUMAN TOXICITY VALUES LD50 MICE INTRAVENOUS 8000 INIOSH. REG TOX.EFFECT CHEM MG/KG SUB 1977] NON-HUMAN TOXICITY VALUES LDLO RABB I TS I NTRAVENOUS 4-200 MG /E~:G C N I OSH. REG TOX EFFECT CHEM SUB 19771 NON-HUMAN TOXICITY VALUES LDLO RABBITS :CNTF,AMUSCULA R 6=cj0 MG/KG [NIO SH. REG TOX EFFECT CHEiI SUB =9177] NON-HUMAN TOX IC I TY VALUES LD50 DJGS ORAL 22 G/F-::G ENIOSH. REG TOX EFFECT CHEM SUB 1977] NON--HUMAN TOX I C I TY VALUES LD50 GUINEA PIGS ORAL 19 G/KG C N I OSH. REG TOX EFF• ECT CHEM 1 SUB 19771 NON-HUMAN TOXICITY VALUES I^nR I TANT DOSE RASB I TS OCULAR 104 MG ENIOSH. REG TOX EFFECT CHEM SUB 1.975] NON-HUMAN TOXICITY VALUES LDLO CHICKENS INTRAVENOUS 27 G/~~::G ECOTOXICITY VALUES INIOSH. REG TOX EFFECT AQUATIC TOXICITY: TLM: CHEM SUB 19781 OVER P!='M/ 9 6 F!f; ENIOSH. REG TOX EFFECT CHEM SUB ].977] ABSORPTION, DISTRIBUTION FROM 1/4 TO 1/2 OF ORAL DOSE GIVEN TO RATS, AND EXCRETION DOGS OR HUMAN... AF'F'EAF;S UNCHANGED IN UR I NE WITHIN 24 HR. CF'ATTY. INDUS ITY G-'-. TsJX '?ND ED ABSORF'TICN, DISTR:ir'UTION AND EXCRETION METADOLISM/METABOLITES VOL2 196=] THE GLYCOLS ARE tiE-LL AI= `=OFiL;En D`( C I%~ErT I VE TRACT AS WELL AS FROM SC & IM INJECTIONS. /GLYCOLS/ [THIENES. CLIN TOX 5TP-{ FD 1972] INJECTED INTO ANI"fAL'S, PART• IS ~~=Xt_RETED UNCHANGE D, F'ART IS OX IDI7-ED TO L;;CTI'; A:_-,ID & f?EMA I NDER I S CONJUGATED W I TH GLYCUF;O.J I C ACID... LLE1-(~UX. F'F,AC 'Fr;X OF F'Lr;STIC`; 1.968] 88698169

THERAPEUTIC USES EXPTAL USE: ALKYLDIOLS WERE COMPARED TO ETHANOL OR PYRAZOLE AS ANTIDOTES IN ETHYLENE GLYCOL TOXICITY. PROPYLENE GLYCOL PROTECTED MICE. ALKYLDIOL ANTIDOTES ARE EFFECTIVE & MAY BE SAFER THAN ETHANOL OR PYRAZOLES. [HOLMAN NW ET AL; ALKYLDIOL ANTIDOTES TO ETHYLENE GLYCOL TOXICITY IN MICE; TOXICOL APPL PHARMACOL 49: 385 (1979)] TI-iERAF'EUT I C USES ITYDROSCOP I C AGENTS (EG, PROPYLENE GLYCOL...) ARE ADDED /TO RESF' INHALANTS/ TO REDUCE VISCOSITY OF BRONCHIAL SECRETIONS. [AMA DRUG EVAL 3RD ED 1977] THERAF'EUT I C USES O I NTMENT CONTA I N I NG AF'F'RO X 70% PROPYLENE GLYCOL HAS BEEN USED AS OSMOTIC AGENT WITH GOOD RESULTS IN TREATMENT OF EDEMA OF CORNEA. CGRANT. TOX OF THE EYE 1974] T!-iERAF'EUT I C USES TOF' I CAL AFFL I CAT I ON OF 40-60y, Ar! SOLN OF PROPYLENE GLYCOL W I TH OCCLUS I ON HAS BEEN REPORTED TO CLEAR Sk:IN IN X-LINKED ICHTHYOSIS i ICHTHYOSIS VULGARIS. [GOODMAN. PHARM BASIS THERAP 5TH ED 1975] THERAPEUTIC USES VET: ORALLY, TO ELEVATE BLOOD GLUCOSE LEVELS I N F'ROF'HYLAX I S & TREATMENT OF ACETONEM I A I N CATTLE. PALATABILITY IS OFTEN POOR, BUT IT IS INEXPEN SIVE. CROSSOFF. HDEsk: VET DRUGS 1974] DRUG WARNINGS TOPICAL EAR DROPS CONTAINING HIGH CONCN OF F'ROr'YLENE GLYCOL ARE CONTRAINDICATED IN CASES W I TH F'EF'FORAT I ON OF TYMF'AN I C MEMBRANE. C VERNON J, r;RUMMETT R, WALSH T; ARCH OTOLARYNGOL 1C:4: 726 (1978)3 PROBABLE EXF'OSURES INDUSTRIAL EXPOSURES ARE FROM DIRECT CONTACT, OR FROM INHALATION OF VAPORS & OF MISTS WHERE MATERIAL IS HEATED OR VIOLENTLY AGITATED. OTHER EXPOSURE IS BY INGESTION RESULTING FROM ITS USE IN FOODS & DRUGS. C F'ATTY. I NDUS HYG & TOX :'ND ED VOL-2 19631 PROBABLE EXPOSURES SINCE ETHYLENE GLYCOL... PRESENT NO SIGNIFICANT HAZARDS UNDER NORMAL INDUST CONDITIONS, NO NEED EXISTS FOR SPECIAL I NDUST HY GI ENE MF_ASURES.... HOtiJEVER... I T I S ADV I SASLE TO PROTECT PERSONNEL L Y ENCLOS I NG PROCESS OR F'ROVIDING LOCAL EXHAUST VENT I LAT I ON. Sk' I N & EYE F'FOTECT I ON SHOULD ALSO BE 1+lOF;N... /GLYCOLS & DER I VAT I VES/ f_Er.ICYC OCCUF'AT HEALTH !: SAFETY 1971] F'ROBAD-LE EXPOSURES APPARENTLY THERE ARE NO REPORTED INDUSTRIAL HAZARDS FROM THIS MATERIAL. CCASARETT. TOXICOLOGY 1975] ANALYTIC LABORATORY ALL COSMETICS: GAS CHROMATOGRAPHY & GLC METHODS COLUMN; =.122. TOBACCO: GAS & COLUMN CHROMATOGi;AFHYq 36.016 & 19.006. DRUGS & VANILLA EXTRACTS: TITRATION. CA`?AC. 1C)TH ED 1965 AND FOLLOWI NG EDS ] 88698170