Tobacco Documents Online

September 27, 1985 UPDATE TO LITERATURE SEARCH N0. 394 TOXICITY AND PYROLYSIS OF PROPYLENE GLYCOL Requested by Elizabeth Wagner

Search Terms: p ropy1 e n e g 1ycol 1,2--propanedicl 5°7..-55-[a SOURCES IN PRINT 1981 Sept. 19}35 1975 Chemical Sources Assn. FLAVOR & FRAGRANCE MATERIALS. Cammerr_e C1 ear i ng House. FOOD DRUG COSMETIC LAW REPORTER. Gor.selin. CLINICAL TOXICOLOGY OF COMMERCIAL PRODUCTS. Heath. SOURCEBOOK OF FLAVORS. KAr. F::-Othmer . ENC YCLOPED I A OF CHEM I CAL TECHNOLOGY. MERCK I NDEX . Opdyke. MONOGRAPHS ON FRAGRANCE RAW MATERIALS. Clayton. F'ATTY'S INDUSTRIAL HYGIENE AND TOXICOLOGY. Sa::. DANGEROUS PROF'ERT I ES OF I NDUSTR I AL MATER I ALS . TOBACCO ABSTRACTS.

SOUF;CES ONLIN_E BRS 8509 Hazardline (HZDB) CAS ONLINE (updated through vol. 103 issue 10, 19F=~5) NATIONAL LIBRARY OF MEDICINE Update Avl. File 9509 (EM) ELHILL. TOXLINE 850? (EM) ELHILL. CANCERLIT 8506 (EM) ELHILL. RTECS 85C>5218 TOXNET. HSDB/TDB (revision date) DIALOG FILE UPDATE NAME 138 1983 Chemical Exposure 174 Nov 82 Chemical Regulations and Guidelines 266 Mar 85 Federal Research In Progress 51 Oct 85 Food Science and Technology Abstracts 79 Aug 85 Foods Adlibra 161 Apr 85 National Institute for Occupational Safety and Health W ( ., U) ~ 0) Ga hA CIF .t~h

RN J7-55-6 IN 1,2-Propanediol (SCI, 9CI) SY P6 12 SY 1,2-Dihydroxypropane SY Methylethylene glycol SY Monopropylene glycol SY Propylene glycol SY .alpha.-Propylene glycol SY 1,2-Propylene glycol SY Sirlene SY 2,3-Propanediol SY Methylethyl glycol SY 2-Hydroxypropanol SY Isopropylene glycol SY Solar Winter Ban SY Ucar •T_•5 SY Solargard P SY Dowfrost DR 63625-56-9 MF C3 HS 02 CI COM, TSCA HOCH2CH(OH)Me REFERENCES IN FILE CAOLD (PRIOR TO 1967) 4217 REFERENCES IN FILE CA (1967 TO DATE) ANS 3 6

~"'~Sd RY OF TO:~~~ ~~~~CTS i O0` C Ll6E MIC`L vIz+UBv TAl;CLS ta A a~ T 60 N A L L16""' Ri=1 R "a' 0 F ME D I C d' Aul E SPECIALIZED INFORMATION SERVICES TO :ICOLOGY INFORMATION PROGRAM

RTECS 1 INTRODUCTION In September 1977, NLM added the 1976 edition of the data retrieval file known as the Registry of Toxic Effects of Chemical Substances (RTECS) to its family of online services. RTECS is structured around individual chemical records of substances with toxic action: The original collection of data that makes up the Registry of Toxic Ef;ects of Chemical Substances was known as the Toxic Substances List, compiled in 1971 by the National Institute tor Occupational Safety and Health (NIOSH) in response to the Occupational Safety and Health Act of 1970. The hard copy version of RTECS is updated annually with quarterly microfiche editions available. The current ONLINE version is based on the 1979 printed edition plus quarterly updates. It contains toxicity data for approximately 53,000 substances (4/82). RTECS is a single source document for basic toxicity Information. RTECS includes toxicity data from a variety of printed sources, threshold lirtiit values, aquatic toxicity ratings, air standards, NCI carcinogenic bioassay information, toxicological/carcinogenic review information, compound classification, and NIOSH Criterion Document availabilty. It is especially useful for retrieving information on a group of compounds or identifying a group of substances on the basis of a selected effect or criterion. Online RTECS gives the user the flexibility of interactive searching and retrieval which can allow focus on subsets of data and data tailored to specific needs. The telephone number for questions on the system, communication problems, program interpretation, etc., is (301) 496-6193 or (800) 638-8480 (toll free). The telephone number for technical assistance in RTECS search strategy, etc., is (301) 496-1131.

3 RTECS UNIT RECORD PRINT OPTIONS SEARCH PRINT S F T D MNEM. DATA ELEMENT MNEM. D U D L (SI) CHEMICAL IDENTIFICATION DATA: Secondary Source ID SI X X X X (N1) CAS Type 1 Name N1 X X X X (SY) Synonyms SY - - - X (NF) Name Fragments - - - - (RN) CAS Registry Number RN X X X X (CC) Classification Code CC - - • X (MF) Molecular Formula MF • - - X (FF) Formula Fragments - - - - Molecular Weight MW - - - X (WL) Wiswesser Line Notation WL - - - X (EM) Entry Month EM - - - X (IX) 'TOXICITY DATA AND SOURCES: Toxicity Data Index String TDKW - X X X (CW) Toxic Data Source SO - X X X STANDARDS, REGULATIONS, AND ADDITIONAL TOXICOLOGICAL DATA: (TW) Chemical Definition CDEF - , - X (TW) Aquatic Toxicity Rating AQ - X - X (TW) Toxicology & Cancer Review TR - X - X (TW) Standards & Regulations SR - X - X (TW) NIOSH Criteria Documents NC - X - X (TW) Status ST - X - X •Note, only the hit sources and/or their associated index strings print unless "COMPLETE" is added to the following print commands, "PRT FU", "PRT DL", "PRT TD", "PRT-TDKW", and "PRT SO".

R7,Z70s SECONDARY SOURCE ID CAS TYPE 1 NAME CAS REGISTRY NUMBER CLASSIFICATION CODE CLASSIFICATION CODE CLASSIFICATION CODE CLASSIFICATION CODE CLASSIFICATION CODE TOXICOLOGY/CANCER REVIEW STATUS STATUS STATUS STATUS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS MOLECULAR FORMULA MOLECULAR WEIGHT WISWESSER LINE NOTATION ENTRY MONTH TOXIC DATA SOURCE TDXDATA KEYWORDS TOXIC DATA MURCE TOXDATA KEYWORDS TOXIC DATA SOUF'CE TOXDATA k:EYWORDS TOXIC DATA SOURCE TOXDATA F::EYWORDS NIOSH/TY2OOOOOU 1,2-PROPANEDIOL 57-55-6 AGRICULTURAL CHEMICAL MUTATION DATA REPRODUCTIVE DATA PRIMARY IRRITANT GERMICIDE TOXICOLOGY REVIEW AJMEAZ Medicine. 38,409,65 American Journal of REPORTED IN EPA TSCA INVENTORY, 1983 EPA GENETIC TOXICOLOGY PROGRAM, JANUARY EPA TSCA SECTION B(e) STATUS REPORT 8EHQ-4178-0041 MEETS CRITERIA FOR PROPOSED RECORDS RULE 47 , 30420, 82 1,2-DIHYDROXYPROPANE DOWFROST METHYLETHYLENE GLYCOL METHYL GLYCOL MONOPROPYLENE GLYCOL PG 12 PROPANE-1,2-DIOL PROPYLENE GLYCOL PROPYLENE GLYCOL USP alpha-PROPYLENEGLYCOL 1,2-PROPYLENE GLYCOL SIRLENE SOLAR WINTER BAN TRIMETHYL GLYCOL C3-H8-02 76.11 DY19x1Q 8506 JIDEAE Journal 55,190,70 OSHA MEDICAL FEREAC 1984 of Investigative Dermatology. SKIN;HUMAN;HUMANS;IRRITATION;S!iU EFFECTS•MILD mg/7D ;TOXIC 85DKA8 "Cutaneous To:<icity," V.A. Drill and P. Lazar, eds., New York, Academic Press, 1977 -,127,77 SF:IN;HUMAN;HUMANS;IRRITATION;104 mg/3D-I TOXIC EFFECTS;MODERATE JIDEAE Journal of Investig-3tive 19,423,52 Dermatology. (Z SKIN;MAN;HUMANS;IRRITATION;10::/2D FCTOD7 Food and Chemical To::icology. 2U,573,82 EYE;RABBIT;RODENTS;IRRITATION;1O0 mg ;TOXIC EFFECTS;MILD

TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA K:EYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE U, TOXDATA KEYWORDS TOXIC DATA SOURCE 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," J.V. Marhold, Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 -,37,72 EYE;RABBIT;RODENTS;IRRITATION;500 mg/24H TOXIC EFFECTS;MODEF(ATE APMUAN Acta Pathologica et Microbiologica Scandinavica, Supplementum. 5274,304,81 MUTATION;DNA INHIBITION;MOUSE;RODENTS SUBCUTANEOUS;8000 mg/kg MUTATION;CYTOGENETICS;MOUSE;RODENTS SUBCUTANEOUS;8000 mg/kg FCTOD7 Food and Chemical Toxicology. 22,623,84 MUTATION;CYTOGENETICS;HAMSTER;RODENTS FIBROBLAST;SOMATIC CELLS;32 gm/L KAIZAN Kaibogaku Zasshi. Journal of Anatomy. 37,239,62 INTRAPERITONEAL;MOUSE;F.ODENTS;TDLo;10q mg/k:g (11D preg);TOXIC EFFECTS;REPRODUCTIVE FERTILITY INTRAPERITONEAL;MOUSE;RODENTS;TDLo;100 mg/kg (15D preg);TOXIC EFFECTS;REPRODUCTIVE EMBRYOTOXICITY JOPDAB Journal of Pediatrics. 93,515,78 ORAL;CHILD;HUMANS;TDLo;79 gm/k:g/56W-I;TOXIC EFFECTS';CENTRAL NERVOUS SYSTEM;BEHAVIORAL SYMPTOMS;CONVULSIONS TXAPA9 Toxicology and Applied Pharmacology. 45,362,78 ORAL;RAT;RODENTS;LD50;20 gm/kg KRKRDT Kriobiologiya i Kriomeditsina. 9,36,81 INTF:APF_RITONEAL;RAT;RODENTS;LD50;6660 mg/k.g TOXIC EFFECTS; JIHTAB Journal of Industrial Hygiene and Toxicology. 31,256,49 SUBCUTANEOUS;RAT;RODENTS;LD50;28 gm/kg NTIS** National Technical Information Service. PD280-477 INTRAVENOUS;RAT;RODENTS;LD50;6800 mg/kg JIHTAB Journal of Industrial Hygiene and Toxicology. 31,256,49 INTRAMUSCULAR;RAT;RODENTS;LD50;20 gm/kg JIHTAB Journal of Industrial Hygiene and Toxicology. 21,173,39 ORAL;MOUSE;RODENTS;LD50;24 gm/kg FEPRA7 Federation Proceedings, Federation of American Societies for E;;perimental Biology. 6,342,47 iNTRAPERITONEAL;MDUSE;RODENTS;LD50;9718 mg/1:g TOXIC EFFECTS;PULMONARY SYSTEM;UROGENITAL SYSTEM;DLDDD KRk:RDT Kriobiologiya i I::riomeditsina. 8,46,81 88698160

G1 TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TQXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS TOXIC DATA'SOURCE TOXDATA KEYWORDS TOXIC DATA SOURCE TOXDATA KEYWORDS SUBCUTANEOUS;MOUSE;RODENTS;LD5O;17370 mg/kg TOXIC EFFECTS;BEHAVIORAL SYMP7OMS;PULMONARY SYSTEM JPETAB Journal of Pharmacology & Experimental Therapeutics. 65,99,39 INTRAVENOUS;MOUSE;RODENTS;LD50;6000 mg/kg JIHTAB Journal of Industrial Hygiene and Toxicology. 21,173,39 ORAL;DOG;DOGS;LD5O;22 gm/kg NTIS** National Technical InFormation Service. PB280-477 INTRAVENOUS;DOG;DOGS;LD5O;26 gm/kg ORAL;RABBIT;RODENTS;LDLo;20 gm/kg NPIRI* Raw Material Data Handbook, V.1 Organic Solvents, 1974. 1,101,74 SKIN;RABBIT;F:ODENTS;LD5O;20800 mg/kg JPETAB Journal of Pharmacology & Experimental Therapeutics. 44,109,32 INTRAVENOUS;RABBIT;RODENTS;LDLo;4200 mg/kg INTRAMUSCULAR;RABBIT;RODENTS;LDLo;6300 mg/kg JIHTAB Journal of Industrial Hygiene and Toxicology. 21,173,39 ORAL;GUINEAPIG;RODENTS;LD50;19 gm/kg NTIS** National Technical Information Service. PB280-477 SUBCUTANEOUS;GUINEAPIG;RODENTS;LDLo;15500 mg/kg JF'ETAB Journal of Pharmacology & Experimental Therapeutics. 60,312,37 INTRAVENOUS;CHICKEN;BIRDS;LDLo;27 gm/kg