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11490 Federal Register / Vol. 58, No. 36 •/ Thursday, February 25. 1993 / Notices ENVIRONMENTAL PflOTEC7fON (FRL-4560-dj Inte9roted Rtsk Information Syst.ta (1RIS)s Announcetnent of Avallebility of t3ackground Paper Aae>rCy: L1:S. Environmental Ptotection Agency. ACTtON: Notice; announcement of avallobility of background paper on IRiS. request for commenu on internal re•riyw. and ennounaement of substancea schoduled for work group , reviuw. suatttArtr: The lntepJated Risk lnformetion SYstarn (gtiS) is a Jata bese uf the United StatMs Fltvtronrner.tal PrMedinn Aqency (EPA) that contaiau EPA scierttitic cunsensus posltions on potential human health effects from e.uvironmantel trontazninants. This tlutice provides information and rrquests infotYr:atius on IRiS for the pu:poces of improving the system and aadrssibg questions tngarding inereased pear re4•iew and publ.+_ participat;on. This notice contains three components. First, it announus the availability of a background paper de+c:ibing iR1S, its contents. and the current proresses used by the two Agoncy work groups rosponsible for devrlaping the IRIS information. .cecond. ii dtscussas an ARency activity to nview IR1S proc«ssas. solirits commants on this arti•rity, and higTlights poutts in the cturent process whare public inp~t is encoumgrd. Tbird, lt anaounr.as a new process for publication of a list of the substances scheduled for IRIS work group review and the solicitntion of pertinent data, studies. and comr.tanu on thasa substances. This list will appear in the Federal Register every six montlu for the nextsix-month period following its publication. The list for March i to December 31, 2993. is provided in tbis notica. Subsequent lists will cover a six• month perio(L OAhs: please submit written comments by Apri112, 2993. aot>rtTssittt: Please send comments, an otiginal and one urbound copy. to: Iris Quality Action Team. Attention: Ltnda C. Ttutan. Room 3809H. Waterside Mall (Rf)-6t9). U5F:PA, 401 M Street, SW., Washington. DC 20460. For a copy of the IRIS Background Pap.r t:onuet: IRIS User Support (Staffed by Computer Sdenas Corporation). USEPA. Environmental Criteria and Assessment Office (MS- i9o), 26 W. Martin Luther King Driw, Cncinnoti. Olf 43268. Telaphone: (513) b09-7254 Facsimite: (s13) 569-7l16. FOR F1lt1'rNER ttitaOR"TtOM CONrAcT: Linda G Tuxan. EPA IRIS Coordinator, Office of Health and Environmental Assessment (R.l}4a9). USF.pA, 403 l.K Street. SW.. Washiagton. DC 20460, Telephone: (202) 260-ti949 Fecstatt7e: 1202? 26a-0393. suP9LttiExrARlr NtronNr.TtON: Saeicground IRIS is an EPA data b.s.. updated mon.thlr. containing Agency consensus sclanti6c positions on potential adverse human health effecta that may rasult ffant oxposun to environmental oontaminants. Currently iR1S contains health eff.cts infortetation on apptox3mately $00 spedIIe substanoea. Sfnoe IRIS was developed trt 1986 and made avaiiable to the public la 1988. its use by EPA and by the environmental health community has grown substantially. EPA uses the d.u base to provide consistent risk information across Ep.P. programs and the regions. States, national and internstiorul arganiutions. and other public and private orgastirations involved with as.+assing potential health hassrds of exposure to a variety of environmental contaminants use DiiS as a source for EPA scientiHc opinion on the potential effeas. EPA saes IRIS as a primary mechanism for communicating technical scienti6c informaUon 9g. potential chronic human hedl~t-bazarda to Agency risk assessors and to trained outside users. The Agency's goal is that 1RLS contain high-quality human hoalth information, besad on credible saence. Availebilitr of liaeiground Paper As one step in the ongoing development of titfawidely used data base. EPA Is reevaluating several aspects of i1i1S. This evaluation. described below (see lnternal Review of IIt1S and Request for Comment). is beinll conducted in a manner that reflects the history, purposas, and goals that led to the initia development of IRIS. This review takes into consideration the current processes used by the two Agency sclentiflc work Foups responsible for dewloptng the health k.iard information in nLTS. TAerefors. EPA bas develo d and Is makin~ available an IRtS eac~rottnd Pa er that eontains the eoat6xttnl iniortnetion described above. For those =ea.rally unfamiliar with the intent and history of IRIS. this paperwill servm as a primer for that infortnation. Far those wlto are regular IRIS usas, tae pepet details the current processes ussd to" develop tlse health ~asard Information on IRIS. especially regardin activities of the work groups responsitie for ISSUE 42 APPENDIX C developing IRIS Information. Interested parsoas are strongly encouraged to obtain this paper as it provides background inforrnation for this Federal Register notice and helps to better understand the context of the Agency's interns] review of IItIS. letteraal Ra.dew ofIR1S and Request for Comment As part of an Agenry -wide effort to Improve the quality of science used to evaluate and manage risks. and because of growing tnterest In IR1S and its role as a widely used resource throughout the risk asaessatent and risk management comntunity. EPA has begun a review of processes by which the information tn IRIS is developed and taaintnined. Tba purposs of this review is to seek ways to Improve how iR1S information is developed and how it Is being used by risk managers. The Agency has taonvened a team to address issues invoiving the quality of information arsd service IRIS provides tbose who use the system, both inside and outside the Agency. The goal of tlte taam is to study the entire IRS process. from nomination of substances through delivery of lnfornsation. The team has been asked to provide a series of recommendations to senior Agency managers to improve quality, (ncluding cortsideratioa of Incseased public involvement and additionaPpeer review and more ef5cient and timely processas. To aehieve this goal. the taam may address conceras that could include: publie involvement, peer review. limitations of IItIS information for rfsk management decisions, and balancing ' the addition of new substances with updates of existing Information. Issuas related to the adequacy of resources devoted to t2te system, itaptowd efficiency and timeliness of the process for adding and updating tfles, effective mechanisnis for issue resolut3on, the quality of and need for regulatory aaion information and supplemental data, outreach and training. and science and methodologiul issues may also be considered In the fuust•e. As a first step In the esora's effort. EPA is focusing on two issues, public involvemant and extornalpeot review. Fcr the purposes of this effon. public involvement is de5ned as opportisnities for affected or Interested parties to have aome level of input Into IRIS health bazard infosutsuon. These groups or Individuals can involve a broader spectrura of participants than external paer revlew. External pear review is dofined as critical appnisal of Agency products by indepen ed nt experts who are peers of those who generate them.

Federal Register / Vol. 58. No. 36 / Thursday. February 25, 1993 / Notices 11491 , Current practias for public involvement and peer review are desaibed in detail 1t+ter In this notice and in the IRIS Background Paper. respectively. Briefly, under eurrent p.er-review procedures, the technical bases for the oral reference dose. Inhalation reference concent»tion. and cancer information on IRIS undergo various levels of internel pear review by EPA sciantists fa:niliar with the substance at Issue. In addition. many undergo external peer review from V ups ranging from the Agency's ence Advisory Board and the Off(a of Pesticide Programs's Science Advisory Panel to specielly-eonvened ptor•review panels and workshops. EPA is secking ways to address concerns for intzeased and irnproved publJe involvement and exianal peer review. The Agency wishes to identify mechanisms that can involve qualified outside scientists and m.mbers of tbe public in improving the quality of Information in )3tIS. while not uAdu)y dolayin the process of adding critical new infosnation to the data bass. Because EPA is bound by statutory and public mandates and schedu)es. the Impact of increased public involvement and peer review on ttise ability of EPA work groups to develop the IRIS Information and on the ability of the data base iuelf to deliver the 1nlormation to EPA programs and regions in a timely manner will also be taken Into consideration by the taem. In this notice. EPA requests comments from the public on these two Issues. The Agency requests infotmation from interested persons on how and how often they use IRIS infotmation and how It affects their decision making. The Agcnry also requests comaenu on the following issues relating to peer review and public involvement: Peer Review- 1. Should decisions made by the EPA work groups responsible for developing the health hazard information on IItIS have further peer-r.view by scientists outside the Agency? 2. iNhat are the adventages and value (to EPA, the regulated community. and the public) of adopting an talunced ~eer-roview system for IRIS iafortn.tion? What are the disadvantages astd problems? 3. What kind of peer-review system should the Agency consider In view of the significanrstatutory , public mandaias, resource and time cons6reinte related to IRIS end its usast What sped6c approach or m.chsaisats should the Agency explora? • Public Involvement- 2. By sending a written Freedom of i. As desaibed later in this notice. Informatlon request for the materials EPA provides severai nurent you need to: )eralene Green. Freedom of opportunities for public involvement Informetion Officer. A-]O1, USEPA. 401 and input Into 1RIS. Whatara the M Street. SW., Washington, DCxoe60, advantages and disadvantages of Under EPA's Freedom of infortnation developing further avenues for public Act procedures. there is no charge for participation in the IRIS processes? duplication of the first 166 pages 2. What are spocific otFier requested. For deta;lod information on opportunities for Improving the science co", call the Freedom of Information and value of IRIS by involving the Ofria at 202-260-4048. public? Cutrsnt Opportunities for Public 3. What should be the goals and Involvement in the IP.IS Process objectives of furtaer public Involvement given the significant statutory, public ts datailedin the companion piece to mandates. resource and time consttaints this notice, the IRIS Background Paper, related to IRIS and its users? Wbat there ue several points In the current X afic approacb or mechanisms IRIS process where public input is uld the Agency explore? encouraged.lR1S users are Invited to The Agency would especially participate in the IRIS information welwme suggestions from members of development process. Four aurent the publia experienced in various forms methods for public involvement and of eer review regarding bow we can input are listed below in a suggested taiPor any peer review to assure hieruchieal order of use.'They are:m optimum use of srlentific talwnt, both s, LRIS Sciensf f/c Canmcts within and outside the Agency, and availabl- resources in addressing the Since 1988, when IItIS was made mostfmportant scientific issues reised. available to the public. the names and Since the turn is in the process of telephone numbers of two EPA staff gathering Infotmation that telates to who are the scientific contacts for a public Involvement and peor review specific assessment have becn inciudod issues. ootnments should be focused on on the data baso. The Agency believes those areas. If parties submit comments that the Inclusion of Agency scientific pertaining to issues other than those of contacts able to discuss the basis for the public Involvement and peer nview. Agency's position is very irnportant. they will be catalogued and reviewed These individuals play e major role in when that issue Is taken up by the team, providing public aeeess to IRIS and Other issues related to IR1S are expected provide a conduit for valued public to be considered at a later time in 1993. amnomt. While the Agency will continue to 2,1R15 Public Reodina Roorrt accept informal comments as it evaluates the IRIS processes, the most Another opportuaity for information helpful comments will be those received access is a newlycreat.d IIt1S Public within 4S days l:om date of this notice. Reading Room located in the library P)ease direct written comments, an facility in the Andrew W. Breidenbach original and one unbound copy, to the Research Center, U.S. EPA. 26 West IRIS Quality Action Teun at the addrnsa Martin Luther King Drive. Cincinnati. given In the beginning of this notioe. OH. which is scheduled to open in the Public comments will be conaidered In Spring of 1993. developin` options for improved The 1WS Public Reading Room has processes for IRIS. EPA a,ill summarize inforraation related to substances on and address the comments received in IR1S. It does not have copies of a subsequent Federal Register notice. carrespondena submitted in nsponse Materuk submitted to the Agency in to the Agency's request for oomments on response to this request for comments the internal review of IRIS that was on the Internal Review activity can be outlined above. To review those Sasp.cted In the following two ways: wmments, follow the directions 1. In peison at the Office of Rewer¢h detailed in the Internal Review of IRIS and Development (ORD). Public and Request for Coaueent section of Informatiom Shelf, EPA Headquarters this notice. IJbrary. 401 M Street SW.. Washington. Visitors will be able to review the DC 20460. The EPA Headquarters documentation files for substances on Library Is open from 10 a.m. to 4 p.m., IRIS. These files contain the background Mondiy.thsflugh Friday except for and supporting material, including a Federal bolidays. Requests for cop ies of synopsis of the scientific discussion these materials cannot be handled by underlying the Rtl?s. RlCs. and phone. If you have any questions about andnogenicity lnformation that ate on the procedur+es for the EPA Library, call IRIS. The files also may indude the 202-260-3922. following: CRAVE and RfD/RfC Work IG

11482 Federal Regfster / Vol. 58. No. 36 1'fbunday. Ftibruary 25. 2993 / Notfoee Group meeting aotes,iWS printouts with bibliographies, public information submucsioas, conaspondence. aed annotated literature s+arsbea. Fil.s for substance assessments not yet oo the svstota wi11 not be available for viewing. ' Individuals wishing to review the documeatstion files for substancea on IRIS should contact the Cincinnati office to schedule in appointment Tha IR3S Glea can be viewed by appotatntent only. Appointments should be sclieduled at least one week in advance and inter,ested parsons should identily the speci fic substances they wish to review at that time. For mora information on the IRIS Public Reading Room or to make an appointment. cantect I]t1S User Support (o ted by Computer Scieneats Corpon oa) at (S13) ss9-7254. The IR1S Public Reading Room is oaly a first stap in providing inctemed access to IRIS processes. At this time, the Agency is unable to respond to informal reqursts for paper copies of the files. As pan of the intemal review of IRIS described prtaviously, the Agency is ' avaluating other means of inotissed Fublic access. J.1RlS It. jormatfon Submission DeA The most imponant of :hv current opportunities Is the IRIS Information Submitsion Dask that was set up In 1Aaa when thoq data besa became publicly available. The Desk staII distribute submissions to the appropriata Ag.n .ry offices for subsequent use in the IRIS inforuution dovelaFment pr»cesses. Tl:e most us+ful submissionsare those received on substances that ara scheduled for initial work group review in tbe near future. This pesmits timely and thorough review and corisideration of a submission as an integral pan of the work groups' scientilic deliberations. EPA hopes that the list ofsubstanees sclteduled for work group review' wntained in this notice will prompt submisrion of scientific comments and annl)yix. stud!es, and id«ntification of otiux pnrtinnnt st:i«ntific inftnrnation from interested persons. New:tttdias end other information on substances already on IRLS are also welcomed. Submissions to the IRIS Informatlon auhnission Desl ere handlr:d in a three- stap process: First, interested persons should simply provide s tist (subr.rssion inventory) and briefly idrntafp all tAe infnrmotion that they wish to submit to the IRIS Information Submission Dask. TSis submission imentory could Include studiw. statistical anatysei ot comments on data interpretation: If appropriate. the materiels should be listed using sdentitSedtation format, that is, author(s)ti tide, lournal, and date. The submittor will receive an acknowl.dgemeot of receipt of the submission inventory. it Is important to note that iatetuted persons should only intlude information that they believe the Agency would not otherwise have, such as unpublisbed studies or other studies not available through standard Utartture searches. Published scientific literature that Is readily identi5able and obtainable should tiot be submitted to the Desk; this Information ta gatbsred during the standard work group review process. The tu+ of the preliminary submission ilventory will help preveat an Influx of duplicative information. The submiaston should includa: A. A cover letter tlsat: • States that the correspondence is an IiiIS Lnforntatiosl submission; • Describes in general tetms the purpose of the sflhmission: and • Includes the names, addnsses, and t«laphone numbers of persons to contact for additional information on th, submission. B. A submission inwntory of all materials tiut persons wish to submit thu • IdeatiLes the substrtaos(s) by n.me erd Qtemiul Abstracts Service ICAS) numbdr(s). If the submission is not relatod to a spuciCtc substan,c.e. but related to in tssua(s) such as dosr tits response extrapolation methodse should be clearly st.ted: e States tAe section of IRIS (for example, oral referenoe dose. Inhalation reference concentration. inhalation carcinogenicity assessment. etc.) that is bwng addressed: and • Lists ar.d describe+ brietlr the information or supporting documents supested for consideration. , in the second step. FPA++(Il identify from the submission inwntory the inforraation that should be subruitt.d. The submitter will receive notifuation requesting submission of the selected moterisl. If certain pieces of information arr not requested for subtntssiorssn explanation will be providaCto the aender. . in the third step. the submitter should send incopies of the Information requested by the Age/teq using the following formst: • Submitters should send t#u.e copies (at Lsst one of which shottldbe unbound); • Submitters sbottld idencfy tAe substance(s) by neme and t3enrid Abstracts Service ICAS) numba(sr • Peraons submitting health elfects data for substance fiJes already on IRIS should include, fur each study submitted,a specific explanation of bow and why the study resuits could change a quantitative risk.alue or relevant IAIS narrative: and • parsons submitting haalth effects data for tbcse sub.taacea scheduled for consideration by the work groups should Inclttde, for each study subraitted. an axplanation of the aigtsi5caace of the study results to a potential RfD oe RfC, eetcinogen useauaent wlna, ete. Submittera aee cautioned t?sat: • Health etfaas data on substancas subject to the reporting rules undar Section !(d) of the Torlc Substsacs Control Act (TSCA1 must be snbmitc.d to the addt+oss given ia the rule. Submitting them to tbe IItiSlnfar••nation Submiss;on Dask dou not relieve pusons from an a(d) reporting, roqufrotaant. • AU sttbtnissions are public Jnfarmatiott. • Confidential Business Information (GB!) should not be submitted to the IRIS information Submission Desk. CBI must be submitted to the epprvpriate office via epptv.ed Agenryproccdures for submission of C8I as codified in the t:oda of Foderal Regulations 140 CFR. Pan 2.-Subpart B). • lf a submitter believes that a f:9I submission contains tnformation with impliutions for J1t7S„it should be noted in the cover letter accompanying the submission. and • Any materials marked t.oafidentiai will be immediately rarurned to the submitter. Once a submission has been evaluated and approptiate work group review and conclusions rstotded, a letter.rill be seot to tha submitter, briefly describing how the inforrnation was evaluated end used. Comaunts on Drinking Water Health Advisories or regulatory summary in formation will not be considered by the 1R1S Infotznation Submission Desk unless the commenter WentiAu an inconsictonry between the Information summarised in IRIS and the actual USF'A Office of Drinking Water Health Advisory or EPA regulatory Informatiort. Questions aboutDriaking Water Health Advisories should be addressed to the Safe Drinking Water Hotline (1-80t)- 426-i791) or the other EPA contact listed for that section on IRIS. Ahboagh EPA regulations are sttmtnarized in IRIS, letters- on the content of rellations will not be considered by thelRiS Information Submission Desk they should be addressed to the EPA program offica responsible for the regulatory action. lnformatioa submissions should be sent to:1RIS Infosrnation Submission

Federal Register I Vol. 58, No. 36 / Thursday. February 25. 1993 / Notices Desk, USEPA. Env'ironmental tTiterta and Assesstaent Office (MS-190), 26 Martin Luther King Drive, Cincinnati. OH 45268. 4. Scientific Seminars A fourth avenue for public Input into development of EPA risk information is to organize a scientific seminar with scientisu from EPA. Requests for a seminar can be originated either by intuvsted outside scientists or by EPA sciontists. This is an opportunity for exchange of Idoas on either a general ydenti5c issue or on a substance•specific topic. ' However, tbase sdentific seminars may not Include policy issua. Sciontifit seminars have been used In the past to examine new approaches to beal,t6 assessment and differences in data interprvtation of key studies. Tbese scientiGc discussions an Invaluable during review of a substance. Scientific seminars should be coordinated with interaeted staff in all appropriate program and research offices. Public Access to IR1S Thare an currontly two means of public access to the IRiS data base. These are supported as official versions of tRIS by the Agency. For further information on these access tnethods. pleue call IRIS User Support at;(513) 569-7254. 1atrAmadrorIna 2• Aeet 1 . AcWeAan ..... Baen . sfoenanae arse .onud CaAohKae ejlenel chbioaatt am CAbral t' ft Y CJhwtne dlodee Ctionle - chlar!• - AhwoTwU1aA CY-rMr Ooromoaawk am O"mer 11 «.. DIrAbeoaeaie eda Ofd~b~odrooarM . OleNbtoproOeM. 1.7- oawo,yt uNnoameentene - prtierilataanorl orsOtkb - pimeaetvqaeudna. 1,1• 01i+RroldwM. 2.4- [ra.twv,rnm wt+aooo laqlOeAameta ~.. [1lvenMA+Yr £e1y1NN 0i/0a fomlald.hyE{ ... 1:TOXNBT The primary method of access for the pnvate sector b the ToXicology Date NETwork (TOXNEi7. which is maintained by the National Library of Medicine (NLM), National Institutes of Health. IRIS has been a component of TOXNET since 1990. TO3NE.Tis an on-line Integrated system that is flexible in search, print, and other commands. Users an easily and quickly extract data either on entire or selected portions of a specirud data field. T0XNTT provides sophisticated search and retrieval features for NLM users. iRlS on TO)cNET isupdated at the begtnning of each moneL with new information, modifications. deletions. revisions, and notifiation of pending actions, as needed. IRIS users cen gain access to TO>24MC by direct call or • through several widely used telecommuniutions networks. IRIS on TOMET is also available through NUd'a International Jr)mLhRS Centers. For further information on gaining access to IRIS via TOlP1E7. contact: IRIS R.ptvsontative, Specialisad Information Servicna Division. National Library of Medicine. $600 Rockville Pike, Bethesda, MD 20894. Telephona: (302) 496-6531. 2. Notiono! Technicol lnformation Service IR1S is also available on high density Sa/." floppy diskettes that may be purchased from the National Tecbaical 31493 Information Service (NTIS). The files are in ASCII format and are Intended for use with a text editor. tRiS diskettes are updated quarterly, while the IRIS data base is updatad monthly:therofore. NTIS diskettes will not always reflect the most current IRIS information. For infotmation on ordering IRIS diskettes, contact: National Techniul Information Service. US Department of Commerce. 5285 Port Royal Road, Springfield. VA 22161,Talophone:(703) 487-4650. The order number for a single set of diskettes is PSO1-3913]1: for e quarterly subscription, the number is P891-591330. Call (800) 553-b847 for RUSH orders. Work Group Substance Roview Schedule and Data Solicitation The following substances are tentatively scheduled for review by EPA work groups during the period from March 1,1993 to December 32. 1903. The list of substances includes those that will be evaluated by the work groups for the first time and those that ars being revisited. In the list below naw substances are designated by N and revisits by R To submit informntion to the IRIS lnformation Submission D.sk, follow the guidelines outlined pnviously. Also. this list of substancas, with appropriate updates tf necessary, is also expected to be available on IRIS itself In the near Futtue. Uyou have questions. please call IRIS User Support at (513) 569-7254. t:a5 Na t:areMe4.n /tN+c a,...uemnt vuMlnYeR [ee.ave+ (CAAVli1 ~ 33-a6-7 N 62at6-f6-i R 7a40•-t1_7 R 7sto-1t-41 R 7e.0a-7 N a1.-+o-. N 1a6:1-26-4 N 7P•11-a N 9tl2•17-0 N 1tleae-et-a N 14e9e-Z7-7 N 1aa6a-aa-s N 7a.i7-0 R 217il.•+e•2 A a71-0-1 N ab1" A 1e1a-0o.s N 7a-4Si N (y) 7a-e7-6 kl tat-7i-e R ~ /0•11-1 N 7•}}4a..7 N ~ 57-14-7 N Cdt 121-1s-2 R W, N j ei-7a-e N Go 131-iar N N aa.ao•o R

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Federal Register / Vol. 58, No. 36 / Thunday, February 25. 1993 1 Notices 11495 Es1N.rr o+w Eery+ Scryrt. FkWnnOnti -M"r rt4qeopooi ne. t.1.1 R.3,].3 Mf0OW 410rf0e 64mOMM M+nDWw WeoM Sed lotqOWift 1+ta" Wo"A kaaw - U.e+NmerAcqA.i. M.0111 Nn" aNf yeprrqneftnWt& 1,4• WOfftWe M" Od oaa+qOwW NPmbiMlt" N•NNploeMpflDNne .~..... N+IUOwN.mNny4rtY ..~.~.- Poroactdotobarawm P.eudWOieeerrr. OeeafM+orobuWr T~ft1AO~Oha~rM Ph.nfgVWr PharO+--w a4MnNw - blYwba -PoqawoArrwO Cpher1r4 « ~ PdyCyOlG etDYtiG RWtM. q+eer Saw+k+m - .r. S11a100TpoUmdt Stiw» atle, _ TM~erbep.drer. 1.12 Z- ._.._. TMONOeo~Vryirrw T.eraT~droivnM ....~.-- T~OfpioN}f~ne. TftlbtoeU+~lY+e •+----w T"lypepOEhWN A list of the substances scbeduled for flWd: Pebsvsey 12.2923. work group review from )eauary 1, Gary ). Fa1.r. 199ti. to June 30.1994. wi11 be AeslnaAssistmuAdminusrsMOrJor(teseo,d, publlshed in the Federal ttegister in endDe+vleprnentL jusunuly.1993. [PR Doc 9J-1197 Filed 2-2e--03s l:aS amI e+uM aooc wa+e-P CAS. N0. 75-2» 1aa-0e..5 :... -A" sa1-89-0 7664.304 fi69-27-6 71~C-e63 8D-l2-i 10a•.o4. 101.TT-e l1-20-9 wlb-7 eFe4 6e4$'1••6 eo.-es-a SS4.13•i 73SCLS-0 3SS-a2-0 eb-01-a 7723-14-0 eO-i" ' 127-e1-1' 1336.76.1 17f-W-O I 7782-s9•2 M-0Z I 7Fi4-6 I 12f-1e-41 a11-e7 2 'i 1DO_Oi-e 71jS-e 74-0ti•e I a2o•.a-!~ 7i.a6.7 7i-01~ 0