Comparison of A Personal and Area Monitor for the Measurement of Ambient Nicotine

Lorillard

Comparison of A Personal and Area Monitor for the Measurement of Ambient Nicotine

Date: 0000 (est.)
Length: 30 pages
87802402-87802431
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Document File: 87802372/87802609/Missing
Alias: 87802402/87802431
Type: SCRT, SCIENTIFIC REPORT; CHAR, CHART/GRAPH/MAPS
Area: SPEARS,ALEXANDER/OFFICE
Litigation: Stmn/Produced
Site: G65
Master ID: 87802382/2470
Named Organization: Oak Ridge Natl Lab
Request: R1-004; R1-132
Named Person: Higgins, C.E.; Jenkins, R.A.; Moneyhun, J.H.; Moody, R.L.
Date Loaded: 05 Jun 1998
UCSF Legacy ID: fsl21e00

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Y COMPAR,ISON OF A PERSONAL, ANDAREA MONITOR FOR THE MEASUREMENT OF AMBIENT NICOTINE Principal Investigator: Roger A. Jenkins Analytical Chemistry Division Oak Ridge National Laboratory Staff Contributors: Cecil E. Higgins Jack H. Moneyhun Ronnie L. Moody ZobZo846

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OBJ ECTIVE Determine the reliability of area sampling, as measured by a PASS-like system, as a predictor of personal exposure to ETS nicotine, as measured by the ORNL Tenax-based monitor. Eobzo848

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a APPROACH * Determine comparability of area and personal monitors in homogeneous test atmosphere over broad range of ETS nicotine concentrations. * Compare response of area and personal monitors under wide variety of field exposure conditions. Vobzoe4e

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COMPARISON OF SAMPLING AND ANAL 1(SIS METHODS . AREA F?ERSOIVAL Sampler containment Ported briefcase ~ Shirt pocket or under suit coat ' Sample pump SKC Dupont Alpha 2 Flow rate, l../min 1.0 0.17 Sample media XAD-4 Tenax Nicotine desorption Ethyl acetate Thermal, at 2500 C. GC Column Capillary Packed Detector N PD NPD sobzoe4e '

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ORNL ETS ROOM TYPE Simulated office SIZE 52 m3 VENTILATION 2.0 - 2.5 ACH CIRCULATION Small Fan MONITORING RSP (TSI 5000, TEOM) NDIR CO, CO2 NOX TEMPERATURE Comparable to surrounding laboratories 9obzoefs

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RESULTS FROM DETERMINATIONS OF NICOTINE BY TENAX AND XAD-4 METHODS (Expcrimcnts in RJR Chambcr) MEAN NICOTINE CONCENTRATIONS (µg/m3) Run No. RSP (µg/m3) ~ 1 55 2 14 3 103 4 62 5 16 6 128 TENAX ORNL XAD-4 RJR (A) XAD-4 RJR (B) XAD-4 2.5 - - - 1.8 - - - 5.0 - - - 4.1 4.1 4.3 4.3 2.1 2.1 2.2 2.3 5.5 5.5 5.9 5.7 4obzo84s

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SIMULATED ETS GENERATION * Modified ORNL Sidestream Apparatus Continuous smolder or Puffing using modified ADL/II (1 puff/min) * Kentucky Reference 1 R4F Cigarettes eobzoe4s

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COMPRBSSSD AIR sobzost.s

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:4 SAMPLING STRATEGY I * Multiple samples taken simultaneously. * All samples acquired within a 1 ft3 volume. * Continuous monitoring of RSP. otVz0eLe

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Table 1 Comparison of Apparent ETS Nicotine Levels Using Two Different Sampling/Analysis Systems Mean ETS Particulate Level' Apparent Nicotine Level (ug/m') (ug/m') Tenax Method XAD-4 Method 4 1.05 ± 0.28 1.01 ± 0.30 18 3.2 ± 1.5 4.4 ± 1.1 38 4.8±-1.7 5e8±1.8 41 4.8 ± 0.9 5.5 ± 2.0 99 15.1±1.8 1 17.3 1.1 225 35.8 1 5.2 36.2 ± 6.6 398 100 ± 11 89.5 ± 2.2 500 - 52.3 ± 11.8 55.1 ± 3.4 738 - 152 ± 21 161 -_* 3.3 849 145 ± 26.6 152 ± 19.2

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