Tobacco Documents Online

14. 4,1.27. Schmeltz, I. and Hoffmann, D. /128. Chemical Studies on Tobacco Smoke L. Nitrogen-Containing Compounds in Tobacco and Tobacco Smoke. Chem. Rev., Vol. 77, 295-311,1977 Brunnemann, K.D., Lee, H.C., and Hoffmann, D. Chemical Studies on Tobacco Smoke. XLVII. On the Quantitative Analysis of Catechols and their Reduction. Anal. Letters, 9, 939-955, 1976. .vI29. Hilfrich, J., Hecht, S.S. and Hoffmann, D. A Study of Tobacco Carcinogenesis XV. Effects of N'-Nitrosonornicotine and N'- Nitrosoanabasine in Syrian Golden Hamsters. Cancer Letters, 2:169-176, 1977. v'130. Dong, M., Locke, D.C. and Hoffmann, D. Separation of Aza-Arenes by High Pressure Liquid Chromatography, J. Chromat. Sci., 15:32-35, 1977: v131. Hoffmann, D., Dong, M., and Hecht, S.S. Chemical Origin in Studies on Tobacco Smoke LII. Tobacco Smoke of N'-Nitrosonornicotine, A Tobacco-Specific Carcinogen: Brief Communication. J. Natl. Cancer Inst. 58: 1841-1844, 1977. "132. Weiss, L., Loy, M., Hecht, S.S., and Hoffmann, D. A Study of Chemical Carcinogenesis. IV. Synthesis of the carbon-14 labelled carcinogens 5-methylchrysene, 2-methylaniline, and 3-methyl-2- naphthylamine. J. Labelled Cpds. and Radiopharma- ceuticals, 14, 119-131, 1978 Y1.33. Dong, M., Locke,-D.C. and Hoffmann, D. Characterization of Aza-Arenes in the basic Organic Portion of Suspended Particulate Matter. Environ. Sci. and Techn. 11: 612-618, 1977. 134. Dong, M., Hoffmann, D., Locke, D.C., and Ferrand, E. Short Communication: The Occur_ence of Caffeine Atm. Environ., 11.,, pp 651-653, 1977.

22. 190. Hoffmann, D., Hecht, S:S., Schmeltz, I., LaVoie, E. and Wynder, E.L. Recent Studies in Tobacco Carcinogenesis: Chemistry, Bioassay and Bioassay Monitoring. In press. 191. Hecht, S.S., Schmeltz, I. and Hoffmann, D. Cocarcinogens in Tobacco Carcinogenesis. In press. 192. Schmeltz, I., Wenger, A., and Hoffmann, D. TLC in the Analysis of the Respiratory Environment. In press.

20. 175. Schmeltz, I., Brunnemann, K.D.and Hoffmann, D. Aza-Arenes and Other Nitrogen-Containing Com- pounds in the Respiratory Environment. Proc. AIChE Meeting, June 1978 in press. 176."// LaVoie, E., Tulley, L., Fow, E. and Hoffmann, D. Mutagenicity of Aminophenyl and N'itrophen 1 Ethers, Sulfides, and Disulfides. Mutat. Res., in press. Tosk, J., Schmeltz, I., and Hoffmann, D. Hydrazines as Mutagens in a Histidine-Requiring Auxotroph of SaZmonella Typhimurium. Mutat. Rest 66, 247-252, 1979. 178. Hecht, S.S., Mazzarese, R., Amin, S., LaVoie, E, and Hoffmann, D. A Study of Chemical Carcinogenesis 15. On the Metabolic Activation of 5-Methylchrysene. Presented at the Internatl. Symp. on Polynuclear Aromatic Hydrocarbons, Columbus, Ohio, Oct. 25-57, 1978. In press. 179. LaVoie, E., Bedenko, V., Hirota, N., Hecht, S.S. and Hoffmann, D. A Comparison of the Mutagenicity, Tumor Initiating Activity and Complete Carcinogenicity of Polynuclear Aromatic Hydrocarbons. Presented at the 3rd IAternatl. Symp. on Polynuclear Aromatic Hydrocarbons, Columbus, Ohio, Oct. 25-27, 1978. In press. Y~80. Schmeltz, I., Wenger, A., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LXIII. On the Fate of Nicotine During Pyrolysis and in a Burning Cigarette. J. Agr. Food Chem. 27, 602-608, 1979. J 181. Hecht, S.S., LaVoie, E., Mazzarese, R., Hirota, N., Ohmori, T., and Hoffmann, D. Y182. A Study of Chemical Carcinogenesis 16. Comparative Mutagenicity, Tumor Initiating Activity, Carcino- genicity, and In Vitro Metabolism of Fluorinated 5-Methylchrysenes. J. Natl. Cancer Inst. In press (1979) Hoffmann, D., Adams, J.D. and Wynder, E.L. Chemical Studies on Tobacco Smoke XLV. Formation and Analysis of Carbon Monoxide in Cigarette Mainstreamand Sidestream Smoke. Prev. Med. 8: 344-350, 1979. QD N N b+ tJ N ba

19. j/167. Hecht, S.S., Chen, C.B., and Hoffmann, D. Tobacco Specific Nitrosamines: Occurrence, Formation, Carcinogenicity, and Metabolism. Acc. Chem. Res. 12: 92-98, 1979. ; - 168. Chen, C_B., McCoy, G.D., Hecht, S.S., Hoffmann, D. and Wynder, E.L. A Study of Chemical Carcino- genesis 10. High Pressure Liguid Chromatographic Assay for a-Hydroxylation of N-Nitrosopyrrolidine by Isolated Rat Liver Microsomes. Cancer Res. 38: 3812-3816, 1978, J169. Chen, C.B., Hecht, S.S., and Hoffmann, D. A Study of Chemical Carcinogenesis 11. Metabolic a-Hydroxylation of Tobacco Specific Carcinogen N'-Nitrosonornicotine. Cancer Res. 38i 3639-3645, 1978. 170./ Hecht, S.S., Hirota, N. and Hoffmann, D. A Study of Chemical Carcinogenesis 12. Comparative Tumor Initiating Activity of ]0-MethyLbenzo(a)pyrene, 7,10-Dimethylbenzo(a)pyrene and -Benzo(a)pyrene. Cancer Letters 5: 179-183, 1978. 171. Hecht, S.S., LaVoie, E„ and Hoi'fmann, D. A Study of Chemical Carcinogenesis 13. Structure- Activity Relationships in Polynuclear Aromatic Hydrocarbons. Proc. of the Lawrence Berkeley Laboratory Conference on Carbonaceous Particles in the Atmosphere. In press. Hoffmann, D., Adams, J.D., Brunnemann, K.D., and Hecht, S.S. Chemical Studies on Tobacco Smoke LXII. Assessement of Tobacco Specific N-Nitrosamines in Tobacco Products. Cancer Res. 39, 2505-2509, 1979. Schmeltz, I., Brunnemann, K.D., and Hoffmann, D. Trace Analysis in Agricultural Products: Methods for Hydrazines, Carbamates, N-Nitrosodiethanolamine and other Compounds. In: "Trace Organic Analysis: A New Frontier in Analytical Chemistry", (H.S. Hertz and S.N. Chester, eds.), pp. 297-309, Natl. Bureau of Standards Special Publ. No. 519, U.S. Govt. Printing Office (No. 003-003-02054-1), Washington, D.C., 1979. Hoffmann, D., Brunnemann, K.D., Schmeltz, I., and Wynder, E.L. Trace Analysis in Respiratory Carcino- genesis. In: "Trace organic Analysis: A New Frontier in Analytical Chemistry", (H.S. Hertz and S.N. Chester, eds.), pp. 131-141, Natl. Bureau of Standards Special Publ. No. 519, U.S. Govt. Printing Office (No. 003-003- 02054-1), Washington, D.C., 1979. 81211326

15. 135./ Hoffmann, D., Schmeltz, I., Hecht, S.S. and Wynder, E.L. Polynuclear Aromatic Hydrocarbons in Tobacco Carcino- genesis. In "Polycyclic Hydrocarbons and Cancer Volume 1: Chemistry, Molecular Biology and Environ- ment." (H. Gelboin and P.O. Ts'o, eds.) Academic Press 1978, pp 85-117 136.`l Hecht, 5.5, Loy, M., Mazzarese, R., and Hoffmann, D. A Study of Chemical Carcinogenesis. 5. On the Carcinogenicity of 5-Methylchrysene: Structure- Activity Studies and Metabolism. In "Polycyclic Hydrocarbons and Cancer," Vol. 1 (H. Gelboin & P.O. Ts'o, eds.) Academic Press 1978, pp 119-130 VJ.37. Hecht, S.S., Chen, C.B., Dong, M., Ornaf, R.M., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LI. Studies on Non-Volatile Nitrosamines in Tobacco. Beitr. Tabakforsch. 9: 1-6, 1977. l138. Hecht, S.S., Chen, C.B. and Hoffmann, D. A Study of Chemical Carcinogenesis 6. Evidence for Metabolic a-Hydroxylation of N-Nitrosopyrrolidine Cancer Res. 38: 215-218,1978 v139. Brunnemann, K.D., Yu, L., and Hoffmann, D. Assessment of Carcinogenic Volatile N-Nitrosamines in Tobacco and in Mainstream and Sidestream Smoke from Cigarettes. Cancer Res. 37, 3218-3222, 1977. 140. Wynder, E.L. and Hoffmann, D. Tobacco and HPa1th: A Societal Challenge. New Engl. J. Med. 300: 894-903, 1979. i/].41. Hecht, S.S., Chen, C.B., Ornaf, R.M., Jacobs, E., Adams, J.D. and Hoffmann, D. Chemical Studies on Tobacco Smoke LVII.* Reaction of Nicotine and Sodium Nitrite: Formation of Nitrosamines and Fragmentation of the Pyrrolidine Ring. J. Org. Chem. 43; 71-76, 1978. V142. Schmeltz, I., Wenger, A., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LIII. Use of Radioactive Tobacco Isolates for Studying the Formation of Smoke Components. J. Agr. Food Chem., 26, 234-239, 1978' i/1.43. Dong, M., Schmeltz, I. and Hoffmann, D. Purification of Quinolines for Bioassay by Preparative High Pressure Liquid Chromatography. J. Chromatogr., 150: 269-272, 1978 ~Pualists No. LII in error.

18. 160. Hoffmann, D., Rivenson, A., Hecht, S.S., Hilfrich, J., Kobayashi, N. and Wynder, E.L. Model Studies in Tobacco Carcinogenesis with the Syrian Golden Hamster. Progr. Exptl. Tumor Res. In print. y161. Hecht, S.S., Chen, C.B., Hirota, N, Ornaf, R.M., Tso, T.C. and Hoffmann, D. A Study of Tobacco Carcinogenesis, XVI Tobacco Specific Nitrosamines: Formation from Nicotine in vitro and during Tobacco Curing and Carcinogenicity in Strain A Mice. J. Natl. Cancer Inst. 60:819-824, 1978 : 162. Wynder, E.L., Hoffmann, D., McCoy, G.D., Cohen, L.A. and Reddy, B.S. Tumor Promotion and Cocarcinogenesis as Related to Man and His Environment. In Carcino- genesis - A Comprehensive Survey, Vol. II, pp 59-77 "Merhanisms of TL=r Pramtion and Cocarcinogenesis. (T.J. Slaga, A. Sivak, and R.K. Boutwell,eds) Raven Press, New York, 59-77, 1978 163. Hecht, S.S., LaVoie, E., Mazzarese, R., Amin, S., Bedenko, V., and Hoffmann, D.. 1,2,-Dihydro-l,2-dihydroxy-5- methylchrysene, a Major Activated Metabolite of the Environmental Carcinogen, 5-Methylchrysene, Cancer Research, 38, 2191-2194, 1978 j/1164. Brunnemann, K.D., G. Stahnke and Hoffmann, D., Chemical Studies on Tobacco Smoke LXI. Volatile Pyridines: Quantitative Analysis in Mainstream and Sidestream Smoke of Cigarettes and Cigars Analytical Letters, All (7), 545-560, 1978. /68. Schmeltz, I, Chiong, K.G. and Hoffmann, D. On the Formation and Analysis of Ethyl Carbamate in ?obacco and Tobacco Smoke. J. Anat. Toxicol 2 (6)f 265-268, 1978. 166. Hecht, S.S., Chen, C.B., McCoy, G.D., and Hoffmann, D. A Study of Tobacco Carcinogenesis XVII. Tobacco Snecific Nitrosamines: Occurrence, Carcino- genicity, and Metabolism. Proc. of the 8th Northeastern Regional Meeting American Chemical Society,Symposium on Nitrosamines, in press. 00 N ~ N CJS

21. 183. Patrianakos, C., and Hoffmann, D. Chemical studies on tobacco smoke. LXIV. On the analysis of aromatic amines in cigarette smoke. J. Anal. Toxicol. In press. 184: /Wynder, E.L,, and Hoffmann, D. Smoking and Health: Pathogenic and Preventive Considerations. Bull. Schweiz. Akad. Med. Wiss. 35: 83-98, 1979. 185. Wynder, E.L., and Hoffmann, D. The Epidemiology and Prevention of Tobacco Related Diseases. Proc. Conf. on "The Epidemiology and Prevention of Tobacco Related Diseases", Heidelberg, Germany (June 1978) . In press. 186. Hecht, S.S., Chen, C.B., McCoy, G.D.F Hoffmann, D. and Domelltlf, L, A study of chemical carcinogene- sis 18. a-Hydroxylation of N-Nitrosopyrrolidine and N'-Nitrosonornicotine by Human Liver Microsomes. Cancer Letters Submitted. 187. Amin, S. Hecht, S.S., LaVoie, E. and Hoffmann, D. A study of chemical carcinogenesis 19. Synthesis and Mutagenicity of 5,11-Dimethylchrysene and Some Methyl-Oxidized Derivatives of 5-Methyl- chrysene. J. Med. Chem. Submitted. 188. Hecht, S.S., Amin, S., Rivenson, A., and Hoffmann, D. A study of chemical carcinogenesis 20. On the Structural Requirements Favoring Carcino- genicity of Methylated Polynuclear Aromatic Hydrocarbons: Comparative Tumor Initiating Activity of 5,11-Dimethylchrysene, 5,12-Dimethyl- chrysene and 5-Methylchrysene. Cancer Letters Submitted. 189. Hecht, S.S., Chen, C.B., Ohmori, T. and Hoffmann, D. A Study of Tobacco Carcinogenesis XVIII. Comparative Carcinogenicity in F-344 Rats of the Tobacco Specific Nitrosamines, N'-Nitroso- nornicotine and 4-(N-Methyl-N-Nitrosamino)-1- (3-Pyridyl)-1-Butanone. Cancer Res. Submitted.

16. V'144. Brunnemann, K.D.B. and Hoffmann, D. Chemical Studies on Tobacco Smoke LIX Analysis of Volatile Nitrosamines in Tobacco Smoke and Polluted Indoor I Environments. IARC Sci. Publ. No. 19, 343-356, 1978. ' p-T15. Dong, M., Schmeltz, I., Jacobs, E. and Hoffmann, D. Chemical Studies on Tobacco Smoke LV. Aza-Arenes in Cigarette Smoke. J. Anal. Toxicol. 2, 21-25, 1978. V1`4 6. Hecht, S.S., Chen, C.B.,Ornaf, R.M.,HOffrann, D. and Tso, T.C. ~ Chemical Studies on Tobacco Smoke LVI Tobacco Specific Nitrosamines: Origins, Carcinogenicity and Metabolism. IARC Sci. PubL. No. 19, 395-413, 1978. 147. Hilfrich, J., Schmeltz, I., and Hoffmann, D. Effects of N'-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian Golden Hamsters., Cancer Letters,4(19781 55-60 /148. Toth, B., Wallcave, L., Patil, K.,:;rhmeltz, I., and Hoffmann, D., Induction of Tumors in Mice with the Herbicide Succinic Acid 2,2-Dimethylhydrazide. Cancer Res. 37, 3497-3500, 1977 +449. Hecht, 5.5., Schmeltz, I. and Hoffmann, D. Chemical Studies on Tobacco Smoke LVIII. Nitrogenous Compounds in Cigarette Smoke and Their Possible Precursors. Rec. Adv. Tob. Sci., 3, 59-63, 1977. 150 ~ Hecht, S.S., Loy, M., Mazzarese, R., and Hoffmann, D., A Study of Chemical Carcinogenesis 8. Synthesis and Mutagenicity Of Modified Chrysenes Related To The Carcinogen, 5-Methylchrysene. J. Med. Chem 21, 38-44, 1978. 151. Hecht, S.S., Hirota, N., Loy, M. and Hoffmann, D. A Study Of Chemical Carcinogenesis 8. Tumor Initiating Activity of Fluorinated 5-Methyl- chrysenes. Cancer Res. 38: 1694-1698, 1978 GD MA N ~- W N W

17. 153. Brunnemann, K.D., Adams, J.D., Ho, D.P.S. and Hoffmann, D., The Influence of Tobacco Smoke on Indoor Atmospheres II. Volatile and Tobacco-Specific Nitrosamines in Main- and Sidestream Smoke and Their Contribution to Indoor Pollution. Proc. 4th Joint Conf. on Sensing of Environm. Pollutants, New Orleans, LA., 1978, PP• 876-880. Schmeltz, I., Tosk, J., Hilfrich, H., Hirota, N., Hoffmann, D. and' Wynder, E.L., Bioassays of Naphthalene and Alkylnaphthalenes for Cocarcinogenic Activity. Relation to Tobacco Carcinogenesis. "Carcinogenesis-A Comprehensive Survey" Vol. 3. pp 47-60 (R.W. Jones and R.I. Freudenthal, eds) Raven Press. New York, 1978. Dong, M., Schmeltz, I., LaVoie, E. and Hoffmann, D. Aza-Arenes in the Respiratory Environment: Analysis and Assays for Mutagenicity. "Carcinogenesis-A Comprehensive Survey" Vol. 3. pp 97-108 (R.W. Jones and R.I. Freudenthai, eds) Raven Press. New York, 1978. Hoffmann, D. and Wynder, E.L. The Less Harmful Cigarette: Present and Future World Smoking and Health, Vol. 2. No. 2 pp 30-34 (Amer. Cancer Soc.) 1977 156. Hoffmann, D. and Wynder, E.L. Identification and Reduction of Carcinogens in the Respiratory Fnvironment. Zentralbl. Bakt. Hyg. I. Abt. Orig. B. 166 113-135 (1978) V157. Hecht, S.S., Carmella, S. and Hoffmann, D. Chemical Studies on Tobacco Smoke LIV. Determination of Hydroxybenzyl Alcohols and Hydroxyphenyl Ethanols in Tobacco and Tobacco Smoke. J. Anal. Toxicol. 2: 56-59, 1978 158 / Hoffmann, D., Hecht, S.S., Schmeltz, I. and Wynder, E.L. Polynuclear Aromatic Hydrocarbons: Occurrence, Formation and Carcinogenicity. Proceedings of the Symposium "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD.,1977, pp..120-128. / 159. Schmeltz, I., Hoffmann, D. and Toth, B. Hydrazines: Occurrence, Analysis and Carcinogenic Activity as related to Structure. Proceedings of the Symposium~ "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD. 1977, ppp. 172-178.