Tobacco Documents Online

11. 101. Brunnemann, K.D., Hoffmann, D., Wynder, E.L., and Gori, G.B. Chemical studies on tobacco smoke. XXXVII. Determina- tion of tar, nicotine, and carbon monoxide in cigarette smoke. A comparison on international smoking conditions. In "Smoking and Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. pn Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U. S. Governmt. Printing Office, Washington, D.C. 1976,441-44g, 102. Schmeltz, I., and Hoffmann, D. Chemical studies on tobacco smoke. XXXVIII. The physico-chemical nature of cigarette smoke. In " Smoking and Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. and Health. (E.L. Wynder, D. Hoffmann and G. U. S. Governmt. Printing Office, Washington, on Smoking B. Gori,eds.) D.C. 1976,13-34. ~ 103. Hoffmann, D., Schmeltz, I., Hecht, S.S., and Wynder, E.L. Chemical studies on tobacco smoke. XXXIX. On the identification of carcinogens, tumor promoters, and co- carcinogens in tobacco smoke. In "Smoking and Health: , I. Modifying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U. S. Governmt. Printing Office, Wash- ington, D.C. 1976, 125-145. 104. Hecht, S.S., Schmeltz, I., Hoffmann, D., and Wynder, E.L. Chemical studies on tobacco smoke. XL. Identification of carcinogens in tobacco. In "Smoking and Health: I. Modi- fying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann, and G. B. Gori, eds.) U.S. Governmt. Printing Office, Washington, D. C. 1976, 191-202. 105. Hoffmann, D. and Wynder, E.L. Selective reduction of tumor- igenicity igenicity of tobacco smoke. III. The reduction of polynuclear aromatic hydrocarbons in cigarette smoke. In "Smoking and Health: I. Mcd4fv_na the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U.S. Governmt. Printing Office, Washington, D.C. 1976,495-504. 106. ' Hecht, S.S., Tso, T.C. and Hoffmann, D. Selective reduction of tumorigenicity of tobacco smoke. IV. Reduction of N-nitrosa.mines and aromatic a::,ines. In "Smoking and ~ Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gcr_, eds.) L'.S. Governmt. Print- N N ~ ing Office, Washir,gton, D. C. 19?6 , 535-5n5. ~ tJ 107. Tso, T.C.,Gori, G.B., and Hoffmann, D. Reduction of nicotine and tar in tobacco and in cigarettes through agricultural techniaues. In "Smoking and Health: I. Modifying the Risk for the Smoker" . Proc. Triird World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. P,. Gori, ec+s.) U. S. Governmt. Printing Office, Washington, D.C. 1976, 35-48.

12. 108. Hoffmann, D., Brunnemann, K.D., Gori, G.B., and Wynder, E.L. On the carcinogenicity of marijuana smoke. Recent Advanc. Phytochem. 9:63-81, 1975 109. Hoffmann, D.,Hecht, S.S., Ornaf, R.M. Tso, T.C., and Wynder, E.L. N'-Nitrosor.ornicotine: Presence in Tobacco, Formation and Carcinocenicity. Chemical studies on tobacco smoke. XLII. Int. Agency Res. Cancer ~ Publ. Monog. 14:307-320,,1976 ~ 1 Hoffmann, D. and Wynder, E.L. Chemical studies on tobacco sr<<oke XLIII. The Active Fractions of Cigarette Smoke in Experimental Tobacco Carcinogenesis. A Review. Tobacco Res. 1:88-97, 1975 111. Hoffmann, D., Hecht, S.S., Schmeltz, I., Brunnemann, K.D. ~ and Wynder, E. L. Chemical Studies on tobacco smoke. XLIV. New separatinn techniques for classes of smoke compounds. Rec. Adv. Tob. Sci. 1, 97-122, 1975. --'fl2. Schmeltz, I. and Hoffmann, D. Formation of Polynuclear Aromatic Hydrocarbons from Combustion of Organic Matter. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 225-239, (R.I. Freudenthal and and P. W. Jones, eds.), Raven Press, New York, 1976 ~ 113. Hecht, S.S., Loy, M. and Hoffmar.r., D. On the Structure and Carcinogenicity of the Methyl- chrysenes. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 325-340 (R.T_. Freudenthal and P.W. Jones, eds.), Raven Press, New York 1_14. J Brunnemann, K.D. and Hoffmann, D. Analysis of Polynuclear Aromatic Hydrocarbons in the Respiratory Environment. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 283-297, (R. I• w r:d P.T.:. Jones, eclls. ), Raven Press, New York, 1976 i 115. Sc: .:,eltz, I., Brunnemann, K. D. , Hof fmann, D. and Cornell, A. Chemical Studies on Tobacco XLV. On the chemistry of cigar smoke: Ccmparisons between experi- mental little and large ciaars. Beitr. Tabakforsch, 8: 367-377, 1976. v' 116. Schmeltz, I., Tosk, J. and :?orf-:a^_n, D. Chemical Studies c- =ohacce XL711'7. Formation and determination of naphthalenes in cigarette smoke. Anal. Chem. 48: 645-650, 1976 117._' Hecht, S.S., Chen, C.B. and Hoffmann, D. ~ Synthesis of N-nitrosamino aldehydes. Tetrahedron Letters. No.8, 593-596, 1976

13. 118. Hoffmann, D. and Wynder, E.L. Smoking and occupational cancers. Prevent. Med.5; 245-261, 1976 - 119. Wynder, E.L., Hoffmann, D., Chan, P. and. Reddy, B. Interdisciplinary and Experimental Approaches: Metabolic Epidemiology in "Persons at High Risk of Cancer, An Approach to Cancer Etiology and Control, pp. 485-501, (J.F. Fraumeni, ed.) Academic Press, N.Y. 1975 1_20. Hecht, S.S., Loy, M., Maronpot, R.R. and Hoffmann, D. A Study of Chemical Carcinogenesis: Comparative Carcinogenicity of 5-Methylchrysene, Benzo (a) pyrene, and modified chrysenes. Cancer Letters 1, 147-154, 1976 v121. Schmeltz, I., Abidi, S. and Hoffmann, D. Chemical Studies on Tobacco Smoke. XLVIII. Analysis of tumorigenic agents in processed (unburned) tobacco: N-Nitrosodiethanola*r.ine and 1,1-dimethyl- hydrazine. Cancer Letters 2,125-132, 1977 ,(-'122. 123. Bru.^.nemann, K. D. , Yu, L. and Hof fmann , D. Chemical Studies on Tobacco Smoke.XLIX. Gas chromato- graphic determination of hydrogen cyanide in tobacco smoke. J. Anal. Toxicol., 1, 38-42, 1977. Wynder, E.L. and Hoffmann, D. Tobacco and Tobacco Smoke. Seminars in Oncology 1: 5-15, 1976 124. Hoffmann, D., Schmeltz, I., hecht, S.S. and Wynder, E. L. Volatile Carcinogens: Occurrence, Formation and Analysis. Detection and Prevention of Cancer. Part I, Vol. 2, Marcel Dec':er, 'New York (1978). pp. 1943-1959 17125. Scr-^eltz, I., Brunnemann, K. D. , Ho_`f mann, D. Analytical Methods for Polynuclear Hydrocarbons. Detection and Prevention of Cancer. Part I, Vol. 2, Marcel Decker (1978). pp. 1973-1992. Hoffmann, D., and b%,ynder, E.T. Organic Particulate Pollutants,Chemical Analysis and Bioassays for Carcino5enicity in: "Air Pollution", 3rd Edition. (Arthur C. Stern ed.), Vo1.II, PartB, pp 361-455 Academic Press.~I. Y. 1977

14. 127. Schmeltz, I. and Hoffmann, D. Chemical Studies on Tobacc^ Smo}.e L. Nitrogen=Containing Compounds in Tobacco ar.d Tobacco Smoke. Cher... =.ev., Vol. 77, 295-311,1977 .~128. Brunnemann, K.D., Lee, H.C., and Hoffmann, D. Chemical Studies on On the Quantitative Tobacco Analysis Smoke. XLVII. of Catechols and their Reduction. Anal. Letters, 9, 939-955, 1976. ~/1.29. Hilfrich, J., Hecht, S.S. and Hoffmann, D. A Study of Tobacco Carcinocenesis Effects of N'-Nitrosonornicotine Nitrosoanabasine in Syrian Golden XV. and.P?'- Hamsters. Cancer Letters, 2:169-176, 1977. (~'130. Dong, M., Locke, D.C. and F-'offl-.ann, D. Separation of Aza-Arenes by High Pressure Liquid Chromatography, J. Chromat. Sci., 15:32-35, 1977. v 131. :Ioffmann, D., Dong, M., and Hecht, S.S. Chemical Studies on Tobacco Smoke LII. Origin_in Tobacco Smoke of N'-Nitrosonornicotine, A Tobacco-Specific Carcinogen: Brief Communication. J. Natl. Cancer Inst. .SL: 1841-1844, 1977. 132. Weiss, L., Loy, M., Hecht, S.S., and uoffmann, D. r Study of Chemical Carcinocenesis. IV. Synthesis of the carbor.-14 labelled carcinogens :,-:let: ylchrysene, t_ ~.._llne, and 3-nethyl-2- naphthylamine. J. Labelled Cp6s. and Radiopharma- ceuticals, 1977, in T_-ess. L~ 133. Donc, M., Locke, D.C. and HoTfT.ann, D. Characterization of Aza-Arenes in the basic Organic Portion of Suspended Particulate Matter. Environ. Sci. and Techn. 11: 612-518, 1977. 134. L'=_, .-i., 'ioffmann, D., S:-:ort Cor.-munication: =^a Jcc•_:Y-er.ce of Caffeine ttm.. Environ., 11, pp 651-653, 1977.

15. 135. Hoffmann, D., Schmeltz, I., Hecht, S.S., and Wynder, E.L. Polynuclear Aromatic Hydrocarbons in Tobacco Carcino- genesis. In"Polycyclic Hydrocarbons in Cancer: Chemis- try, Molecular Biology and Environment." (H. Gelboin and P.O.Ts'o, eds.) Academic Press. in print ";'136. Hecht, S.S., Loy, M., Mazzarese, R., and Hoffmann, D. On the Carcinogenicity of 5-methylchrysene: Structure- Activity Studies and Metabolism. Proc. U.S.-Japan Cooperative Cancer Res. Program, New Orleans, La., Jan., 1977. ____137. Hecht, S.S., Chen, C.B., Dong, M., Ornaf, R.M., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LI. Studies on Non-Volatile Nitrosamines in Tobacco. Beitr. Tabakforsch. 9: 1-6, 1977. ~' 138. Hecht, S.S., Chen, C.B. and Hoffmann, D. ' A Study of Chemical Carcinogenesis VI. Nitroso- pyrrolidine Carcinogenesis: Evidence for Metabolic a-Hydroxylation. Cancer Res. 38: 215-218, 1978. L139. Brunnemann, K.D., Yu, L., and Hoffmann, D. Assessment of Carcinogenic Volatile N-Nitrosamines in Tobacco and in Mainstream and Sidestream Smoke from Cigarettes. Cancer Res. 37, 3213-3222, 1977. %- 140. t..yr_der, E.L. and Hoffmann, D. Tobacco and Health: A Societal Challenge. Scientific American ~ 141. Hecht, S.S., Chen, C.B., Ornaf, R.M., Jacobs, E., Adams, J.D. and Hoffmann, D. Chemical Studies on Tobacco S:-:.o3-e LVIT.* Reaction of Nicotine and Sodium r:itrite: Formation of Nitrosamines and Fragmentation of the Pyrrolidine Ring. J. Org. Chem. 43, 72-75, 1978. 142. Schmeltz, I., Wenger, A., Hoffmann, D. and Tso, T.C. Che-.ical Stuc:ies on Tohaccc Use of' Radioactive Tob3cco Isolates for Studying the Formation of Smoke Components. J. Agr. Food Chem., in press. 143. Dong, M., Schmeltz, I. and Hoffmann, D. Purification of Quinolines for Bioassay by Preparative High Pressure Liquid Chromatography. J. Chromatogr., "Pub1- lists No. LII in error.

16. 144. 145. 146. ~ 147. 148. 149. l 150. .; 151. Brur_nenz.nn, K.D.B. and Hoffmann, D. Chemical Studies on Tobacco Smoke LIX Analysis of Volatile Nitresamines in Tobacco Smoke and Polluted Indoor Environments. IARC Sci. Publ. In press Dong, M., Schmeltz, I., Jacobs, E. and Hoffmann, D. Chemical Studies on Tobacco Smoke LV. Aza-Arenes in Cigarette Smoke. J. Ana.l._Tocicol. In press. Hecht, S.S., Chen, C.B., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LVI Tobacco Specific Nitrosamines: Origins, Carcinogenicity and Metabolism. IARC Sci. Publ. _Tn press. Hilfrich, J., Schmeltz, I., and Hoffmann, D. Effects of N'-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian Golden Hamsters., Cancer Letters, In press. Toth, B., 6"lallcave, L., Patil, K.,Schmeltz, I., and Hoffmann, D., Induction of Tumors in Mice with the Herbicide Succinic Acid 2,2-Dimethylhydrazide. Cancer Res. 37, 3497-3500, 1977 Hecht, S.S., Schmeltz, I. and Hoffmann, D. -Chemical Studies on Tobacco Smoke LVIII. Nitrogenous Compounds in Cicarette Smoke and Their Possille Precursors. Rec. Adv. Tob. Sci., 3, 59-63, 1977. Hecht, S.S., Loy, M., Mazzarese, R., and Hoffmann, D., A Study of Chemical Carcinogenesis 7. Synthesis and rlutagenicity Of riodified Chrysenes Related To The Carcinogen, 5-Yethylchrysene. J. Med. Chem 21, 38-44, 1978. - Hecht, S.S, Hirct , _:. , -c_ , --. ---.. --c=f,.:ann, D. A Study Of C:^e_._-cal Carc`_::c -.`.._s 8. Tumor Initiating Activity of Fluorinated 5-Methyl- chrysenes. SuLmitted.

17. 152. Brunnemann, K.D., Adams, J.D., Ho, D.P.S. and Hoffmann, D., The Influence of Tobacco Smoke on Indoor Atmospheres 'II. Volatile and Tobacco-Specific Nitrosamines in Main- and Sidestream Smoke and Their Contribution to Indoor Pollution. Proc. 4th Joint Conf. on Sensing of Environm. Pollutants, New Orleans, La, 1977, in press. 153. SChmeltz, I, Tosk, J, Hilfrich, H, Hirota, N., Hoffmann, D. and Wynder, E.L., Bioassays of Naphthalene and Aikylnaphthalenes for Cocarcinogenic Activity. Relation to Tobacco Carcinogenesis. "Polynuclear Aromatic Hydrocarbons". Vol. 2 (Jones and Freudenthal, eds). Raven Press. In print ' 154. Dong, M., Schmeltz, I., LaVoie, E. and Hoffmann, D. Aza-Arenes in the Respiratory Environment: Analysis and Assays for `?utagenicity.In "Polynuclear Aromatic Hydrocarbons." Vol. 2 (Jones and Freudenthal, eds) Raven Press. In print 155. Hoffmann, D. and Wynder, E.L. The Less Harmful Cigarette: Present and Future World Smoking and Health, Vol. 2. No. 2 pp 30-34 (Amer. Cancer Soc.) 1977 156. Hoffmann, D. and Wynder, E.L. Identification and Reduction of Carcinogens in the Respiratory FnvironT.ent. Zentralbl. Ba':t. Hvg. I. Abt. Orig. B. 544 888 - (1977) 157. Hecht, S.S., Carmella, S. and Hoffmann, D. Chemical Studies on Tob-acco Smoke LIV. Determination of Hydroxyber_zyl Alcohols and I'.ydroxyphenyl Ethanols in Tobacco and Tobacco S:r,oke. J. Anal. Toxiccl. Sub:,,_`t-led. 158. Hoffmann, D., Hecht, S.S., Schmeltz, I. and Wynder, E.L. Polynuclear AroT-:ati c H'.dYocar1D o=~s : Occurrence, Formation and Carcinogenicity. Proceedings of the Symposium "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD. August, 1977. 159. Schmeltz, I., Hoffmann, D. and Toth, B. Hydrazines: Occurrence, Analysis and Carcinogenic Activity as related to Structure. Proceedings of the Symposium "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD. August, 1977.

18. 160. Hoffmann, D., Rivenson, A., Hecht, S.S., Hilfrich, J., Kobayashi, N. and Wynder, E.L. Model Studies in Tobacco Carcinogenesis with the Syr-an Golden Hamster. Progr. Exptl. Tumor Res. = ^rint. ,_~,.7.61. Hecht, S.S., Chen, C.B., Hirota, N, Ornaf, R.M., Tso, T.C. and Hoffmann, D. A Study of Tobacco Carcinogenesis, XVI Tobacco Specific Nitrosamines: Formation from Nicotine in vitro and during Tobacco Curing and Carcinogenicity in Strain P_P1ice. J. Natl. Cancer Inst. In Pre--s. -, v& o ",,/ 1+;. / iy?~; / d'i 1~-~a 5/. 162. Wynder, E. ~. ,iio fmann, D. ,:IcCoy, G. D. , Cohen, L.A. and Reddy, B.S. Tumor Promotion and Cocarcinogenesis as Related to Man and His Environment. In "Carcino- genesis", Vol. 2. "Mecnanisms of Tumor Promotion and Cocarcinocenesis. (T.J. Slaga, A. Sivak, and R.K. Bont%eell, eds. ) P.aven Press, New Yor?-, 1978. In print. ~ 163. Hecht, S.S., LaVoie, E., Mazzarese, R., Shantilal, A., Bedenko, V., and Hoffmann, D.. 1,2,-Dihydro-1,2-dihydrocy-5- methylchrysene, a Major Activated Metabolite of the Environmental Carcinogen, 5-I,4ethylchrysene, Cancer Research