Tobacco Documents Online

BI BL I OGRAPHY Dietrich Hoffmann, Ph.D. Wynder, E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. VII. The Role of Higher Polycyclic Hydrocarbons. Cancer 12: 1079-1086, 1959. ^ . 1--'2. Wynder, E.L. and Hoffmann, D. The Carcinogen1city of Benzofluoranthenes. 11~!~-1199, Nov.-Dec. 1959. 7 3. Cancer 12: Wynder, E.L. and Hoffmann, D. Tobacco Smoking as a Cause of Cancer. Cancer Progress, Butterworths, London, Vol. 1°60, pp. 77-80. /4. Hoffmann, D. and Wynder, E.L. Short-Term Determination of Carcinogenic Aromatic Hydrocarbons Anal. Chem. 32: 295, February 1960. 5. Wynder, E.L. and Hoffmann, D. Some Practical Aspects of the Smoking-Cancer Problem. New Engl. J. Ned. 262: 540-545, March 1960. v 6. Ilofflnann, D. and Wynder, E.L. On the isolation and Identification of Polycyclic Aromatic Hydrocarbons. Cancer 13: 1062-1073, September-October, 1960. `~7 - W ynder, E.L. and Hoffmann, D. Present Status of Laboratory Studies on Tobacco Carcinogenesis Acta Pathol. Microbiol. Scand. 52: 119-132, Fasc. 2, 1961. ~ 8. 'Biekert, E., Hoffmann, D., and Meyer, F.J. Uber 1.4-Oxazine, I. Chem. Ber. 94: (6), 1676-16E'2, 1961. "2 9. Biekert, E., Hoffmann, D. and Meyer, F.J. Uber 1.4 Oxazine, II. Chem. Ber. 94: (6), 1676-16'.2, 1961. ~ 10. Hoffr,ann, D. and Wynder, E.L. A Study of Air Pollution Carcinogenesis. II. The Isolation and Identifi cation of Poivii:iclear iiro:lat-ic H11CGrocdrhoI7:; from Gasoline Engine Exhaust. Cancer ^15: 93-102, Januar.y-. February, 1962. __111. Wynder, E.L. and Hoffmann, D. #I A Study of Air Pollution Carcinogen~,sis. III. Carcinogenic Activity of Gasoline Engine Exhaust Tar. Cancer 115: 103-108, January-February, 1962. 81211302

2. -1"12. Hoffmann, D. and Wynder, E.L. Die quantitative Bestimmung von Phenolen im z-`~13. W ynder, Tabakrauch. Beitr. Tabakforsch. 1:101-106, August 1961. E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. VIII, The Role of the Acidic Fractions as Promoters. Cancer 14: 1306-1315, November-December 1961. ~ 14. Biekert, E., Hoffmann, D. and Enslein, L. Ueber 1.4 Oxazine IV. Kondensation von 1,2-Amino- alcoholen mit Ketocarbons3ureestern zu 5,6-Dihidroxy- 1.4-Oxazinonen (2). Chem. Ber. 94: (10) 2778-2785, 1961. P--'15. Wynder,- E.L. and Hoffmann, D. Carcinogenicity of Dibenzo(a,l)pyrene. Nature (London) 192: 1092-1093, 1961. Hoffmann, D. and Wynder, E.L. Analytical and Biological Studies on Gasoline Engine Exhaust. Natl. Cancer Inst. Monograph 9:91-116, 1962. "'l 7. Hoffmann, D. and Wynder, E.L. /. . ~ Filtration of Phenols from Cigarette Smoke. J. Natl. Cancer Inst. 30: 67-84, January, 1963. 117a. Holffmann, D. and Wynder, E.L. Die Filtration von Phenolen aus Cigarettenrauch. Beitr. Tabakforsch. 2:51-66, June 1963. 18. Hoffmann, D. and Wynder, E.L. Studies on Gasoline Enc~ine Exhaust. J. Air Pollutio:, Control Assoc. 17: 322-327, July 1963. "The Role of Skin I:eopiasia in To:-acco Carcinogenesis. In: "Tobacco And Health" (G.G. James and R. Rosenthal, eds.) pp. 61-7=. C.C. :cas, Sa- i^gfield, Illinois. V"19. W ynder, E.L. and Hoffmann, D. 20. Wynder, E.L. and Iloffmann, D. W N Air Pollution and Lung Cancer. ZV Proc. Natl. Conf. Air Pollution, pp. 143-148, 1963. N w 21. 1ioffmann, D., Rathkamp, G., and Wynder, E.L. G~„~, Comparison of the Yields of Several Selected Compor~ nts in the Smoke from Different Tobacco Products. J. Natl. Cancer Inst. 31: 627=637, September 1963. n

3. t-"21a. Hoffmann, D., Rathkamp, G., and j,7inder, E.L. Vergleich der AuL;beute an mehreren ausgew3hlten Komponenten im Rauch verschiedener Tabakerzeugnisse. I3eitr. Tabakforsch. 2:123-130, February 1964. 1-"22. Wynder, E.L. and Hoffmann, D. Ein Experimenteller Beitrag zur Tabakrauchkanzero- genese. Deut. Yed. .•7ochschr. 88: 623-628, March ~ 1963. 1,'~23. ~` Wynder, E.L., Kaiser, H.E., Goddman, D.A., and Hoffmann, D. A method for Determining Ciliastatic Components ' in Cigarette Smoke. Cancer 16:1222-1225, September + 1963. ~ - --., 24. Wynder, E.L. and Hoffmann, D. Experimental Aspects of Tobacco Carcinogenesis. Diseases Ches. 44: 337-346, October 1963. ~ 25. c•Jynder, E.L. and Hoffmann, D. Experimental Tobacco Carcinogenesis. in Cancer Res. 8: 249-453, 1964. Advances 26. Wynder, E.L. and Hoffmann, D. Reduction of Tumoricenicity of Cigarette Smoke. J. Am. Med. Assoc. 192: 88-94, April 12, 1965. /27. Hoffmann, D., Theisz, E., and ;vynder, E.L. Studies on the Carcin^genicity of Gasoline Exhaust. J. Air. Pollution Control Assoc. 15: 162-165, April 1965. (/28. -~•:ynder, E.L. and Ho_=:-:iar.n, D. Some Laboratory and E,piderniological Aspects of Air Pollution Carcino~;er,esi:~ .. J. Air Pollution Control Assoc. 15:155-'_59, April 1965. v 29. 1'Iyndej7, W.L., Goodman, D.A. and ?:offmar.n, D. Ciliatoxic Co,-.ponents in Cigarette Smoke. II. Carboxylic Acids and t,ic3enydes. Cancer 1£3:505-509, --'~'3 0 Wynder April 1965. and Hoffmann A D E Goodman L D . , , ., , . . ., . I A Ciliatoxic Components in Cigarette Smoke. III. P N In Vitro Comparison of Different Components. N Cancer 18: 1652-1658, 1965. W ' O ~ . 31. Wynder, E.L. and Hoffmann, D. Current concepts of environmental Cancer Research. ' Med. Clin. N. Am. 50:631-650, 1966.

4. ~ 32. Hoffmann, D. and Wynder, E.L. Beitrag'zur carcinogenen Wirkung von Dibenzpyrenen. Z. Krebsforsch. 68: 137-149, 1966. 7 33. wynder, E.L. and Hoffmann, D. Beziehungen zwischen Epidemiologie und experimenteller Kanzerogenese. rluench. Med. Wochschr. 108:1501-1512, 1966. ~/34. Hoffmann, D. and Rubin, J. '. '. Chemical Studies on Tobacco Smoke. I. The QLa nfitative Determination of indoles in Cigarette Smoke. Beitr. Tabakforsch. 3:409~414, 1966. ~35. Hoffmann, D., Rathkamp, G. and Rubin, J. Chemical Studies on Tobacco Smoke. II. Comparison of the Yields of Several Selected Components in the. Smoke from Five Major Turkish Tobacco Varieties.~ Food. Cosmet. Toxicol. 5:37-38, 1967. VI 36. Hoffrnann, D, and Wynder, E.L. The Reduction of the Tumorigenicity of Cigarette Smoke Condensate by Addition of Sodium Nitrate to Tobacco. Cancer Res. 27:7.72-174, 1967. 1? 37. Wynder, E.L. and Hoffmann, D. -~38. "Nutrition and Cancer". In: (R.W. Raven and F.J.C. Roe, woths, London, 1967. SAJhnder, E.L. and Ho_fmann, D. "The Prevention of Cancer" eds.) pp. 11-18; Butter- "Tobacco And Tobacco Smo';e. Studies in Experimental Carcinogenesis". Acadernic Press, 730 pp. New York 1967, '~39. b•lynder, E.L., Taguchl , K., Baden, V., and Hoffmann, D. A Study in Tobacco Carclno~.~;renesis. IV. The Effect of Cigarette Smoke on the Respiratory Tract of rlice ' After Passive Inha?ation. Cancer 21, 134-153, 1968. U. ---4 Ho_ffmann, D., and ;•Jynder, E.L. Chemical Analysis and Carcinogenic F3ioassay~i of Organic Particulate Pollutants. Chapter 20, Vol. II in Air Pollution. Ed. A.C. Stern. 187-247, Academic Press, New York, 1968.

5. ~ 41. Wynder, E.L. and Hoffmann, D. Selective Laboratory "•7ethods in Tobacco Carcino- genesis in Vol. IV "Nethods in Cancer Research" Ed. H. Busch. 3-52, Academic Press, New York, 1968. V"42. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke. III. Primary and Secondary Nitroalkanes in Cigarette Smoke. Beitr. Tabakforsch. 4(3):124-134, 1968. 43. v Hoffmann, D. and Wynder, E.L. Selective Reduction of the Turnorigenicity of Tobacco Smoke. Experimental Approaches. Monogr. Natl. Cancer Inst. 28:151-172, 1968. 1/44. Hoffmann, D. and Woziwodzki, H. Chemical Studies on Tobacco Smoke. IV. Free Nonvolatile Fatty Acids in Tobacco and Cigarette Smoke. Beitr. Tabakforsch. 4(4):167-175, 1968. ,~45. Hoffmann, D. and Rathkamp, G. Checmical Studies on Tobacco Smoke. V. Quantitative Determination of Chlorinated Hydrocarbon Insecticides in Cigarette Tobacco and Its Smoke. Beitr. Tabakforsch. 4(5):201-214, 1968. ,/- 46. Wynder, E.L. and Hoffmann, D. -47.~ Wynder, Ex;Derimental Tobacco Carcinogenesis. Science 162:862, Nov. 22, 1968. E.L. and Hoffmann, D. ''Bioassays in Tobacco Res. 11:163-193, 1968. Carcinogenesis". Progr. Tumor c-,-48. HOffmann, D. , Masuda, Y. a 1d 'r'l j:der, E.L. Chemical Studies on Tobacco Smoke. VII. a-Naphthylamine and 13-Naphthylamine in Cigarette Smoke. Nature 221:254- 256, 1969. v49 . Hoffmann, D., Rathkamp , G. and Woziwodzki, H. Chemical Studies on Tobacco Smoke VI. Quantitative Determination of Carbazoles in Cigarette Smoke. Beitr. Tabakforsch. 4(6):253-263, 1968. V"5J. *aasuda, Y. and Hoffnann, D. Chemical Studies nn Tobacco Smoke. VII. Quantitative Determination of 1-Naphthylamine and 2-Naphthylamine in Cigarette Smoke. Anal. Chem. 41:650-652, 1969.

6. ~ 51. Wynder, E.L. and Hoffmann, D. Current Studies in Etiology and Prevention. In "Lung Cancer: A Study of 5,000 Memorial Hospital Cases". Ed. W.L. Watson, C.V. Mosby ComD. St. Louis, Mo., 15-34, 1969. 52. Hoffmann, D., Rathkamp, G. and Nes=:7, S. Chemical Studies on Tobacco Smoke. VIII. Quantitative Determination of 9-Methylcarbazoles in Cigarette Smoke. Anal. Chem. 41:1256-1259, 1969. z'~53. Wynder, E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. X. Tumor Promot4-ng Activity. Cancer 24:289-301, 1969. ,,,54. Hoffmann, D., Rathkamp, G. and .lynder, E.L. Chemical Studies on Tobacco Smoke. IX. Quantitative Analysis of Chlorinated Hydrocarbon Insecticides. Beitr. Tabakforsch. 5:140-148, 1969. 1--55. Masuda, Y. and Hoffmann, D. A Method for the Determination of Primary Amines of Polynuclear Aromatic Hydrocarbons. J. Chromatog. Sci. 7:694-697, 1969. ,/ 56. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke. X. Quantitative Determination of 1-Alkylindoles in Cigarette Smoke. Anal. Chem. 42:366-370, 1970. ~ 57. Hofrmann, D. and Wynder, E.L. Chamber Development and Aerosol Dispersion. U.S. At. Energ. Symp. Ser. 18:173-191, 1970. ,, 58 Hoffmann, D. and Mazzola, V. Chemical Studies on Tobacco Smoke. XI. Dibenzofurans in Cigarette Smoke. Beitr. Tabakforsch. 5: 183-188,1970 ,--59. Hoffmann, D. and Rathkamo. G. Chemical Studies on Tobacco Smoke. XII. Quantitative Determination of Nitro'oenzenes in Cigarette Smoke. Anal. Chem. 42: 1643-1647, 1970 '~60. Wynder, E.L. and Hoffmann, D. The Eaidermis and the Tract as Bi oassa-v S•7stems in Tobacco Carc-__oc -_~_s. Brit. J. Cancer. 24: 574-587, 1970 ~ 61 . Ho f fmann , D. and TnTynde r, E. L. A Study of Tobacco Carcinogenesis. XI. Tumor Initiators.,.Cancer27: 848-864, 1971 62. Rath kamo, G. and Hoffmann, D. Chemical Studies on Tobacco Smoke. XIII. Inhibition of the Pyrosynthesis of Several Selective Smoke Constituents. Beitr. Tabakforsch.,5: 302-306, 1970

7. 1/53. Marquardt, H., Bendich, A., Philips, F.S., and Hoffmann, D. Binding of [G-3H]-7,12-Dimethylbenz[a]anthracene to DNA of Normal and of Rapidly Dividing Hepatic Cells in Rats. Chem.-Biol. Interaction, 3: 1-11, 1971 ~ 64. Hoffmann, D. and Wynder, E.L. Respiratory Carcinogens: Their Nature and Precursors. In: "Proc. Intern. Symp. on Identification and Measurements of Environ. Pollutants" (I. Hoffman, ed.) 9-16, Campbell Printing, Ottawa, Canada, 1972 - 65. Wynder, E.L. and Hoffmann, D. Carcinogens in the air. Proc. 24th Annual Symp. on Fundamen- tal Cancer Research, Houston, Texas, 118-138, 1972 v 66. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke, XIV. Quantitative Deter- mination of Fluorenes in Cigarette Smoke and their Formation by Pyrosynthesis. Anal. Chem., 44: 899-904, 1972 ,,~67. Hoffmann, D. and Wynder, E.L. Chemical Studies on Tobacco Smoke. XV. Chemical Composition and Tumorigenicity of Tobacco Smoke. In: "The Chemistry of Tobacco and Tobacco Smoke" (I. Schmeltz, ed.), 123-147, Plenum Press, New York, N.Y., 1972 6--'68. Wynder, E.L. and Hoffmann, D. Less Harmful Ways of Smoking. J. Nat. Cancer Inst., 48: 1749-1758, 1972 c. 69. Hoffmann, D. and Wynder, E.L. Selective Reduction of the T=origenicity of Tobacco Smoke.II Experimental Approaches. J. Nat. Cancer Inst., 48: 1855-1868, 1972 V70. Hoff::lann, D., Rathkamp, G., Nesnow, S., and Wynder, E.L. - Fluoranthenes: Quantitative Deter:mir:ation in Cigarette Smoke, Formation by Pyrolysis and Tumor Initiating Activity. J. IvTatl. Cancer Inst., 49: 1165-1175, 1972 t% 71. Hoffmann, D. and Wynder, E.L. Chemical Studies on Tobacco Smoke. XVIII. Smoke of Cigarettes and Little Cigars: An Analytical Comparison, Science, 178: 1197-1199, 1972 ~ 72. HoffmaZn, D. Benzo[a]pyrene in Polluted _~~4r. Prevent. Med., 1: 450- 451, 1972 1--'73. Liu, Y.Y., and Hoffmann, D. Chemical studies on tobacco smoke. XIX. nuantitative Chromatographic determination of maleic hydrazide in cigarette smoke. Anal. Chem., 45: 2270-2273, 1973

8. ~74. Rathkamp, G., Tso, T.C., and Hoffmann, D. Chemical studies on tobacco smoke. XX. Smoke analysis of cigarettes made from Bright tobaccos differing in variety and stalk positions. Beitr. Tabakforsch., 7: 179-189, 1973 - i ~/75. Tso, T.C., Rathkamp, G., and Hoffmann, D. Chemical studies on tobacco smoke. XXI. Correlation and multiple regresssion among selected cigarette-smoke constituents and leaf characteristics of Bright tobacco. Beitr. Tabakforsch., 7: 190-194, 1973 c-~76. Hoffmann, D., Rathkamp, G., Brunnemann, K.D., and Wynder, E.L. Chemical studies on tobacco smoke. XXII. On the profile analysis of tobacco smoke. Sci. Total Environ., 2: 151- 171, 1973 - 77. Hu, M.W., Bondinell, W.E., and Hof`mann, D. Chemical studies on tobacco smoke. XXIII. Synthesis of carbon-14 labelled myosmine, nornicotine, and N'-nitroso- nornicotine. J. Labelled Compounds, 10: 79-88, 1974 ~78. Hoffmann, D., Bondinell, W.E. and Wynder, E.L. Carcinogenicity of methylchrysenes. Science, 183: 215-216, 1974 L--79. L 80. Brunnemann, K.D. and Hoffmann, D. Chemical studies on tobacco smoke. XXIV. A quantitative method for carbon monoxide and carbon dioxide in cigarette and cigar smoke. J. Chrom. Sci., 12: 70-75, 1974 Brunnemann, K.D., and Hoffmann, D. Chemical studies on tobacco smoke. XXV. The pH of tobacco smoke. Food. Cosmet. Toxicol., 12: 115-124, 1974 81. Hoffr^ann, D. and Wynder, V.L. 7 Environmental respiratorv carcinoaenesis. In: "Chemical Carcinogenesis" (Searle,lC.E., ed.), ACS Monograph, 173, American Chemical Society, Washingron, D.C. 324-365, 1976.

9. 82. Hoffmann, D., Rathkamp, G., and Liu, Y.Y. Chemical studies on tobacco smoke. XXVI. On the isolation and identification of volatile and non- volatile N-nitrosamines and hydrazines in cigarette smoke. Int. Agency Res. Cancer Publ., Monogr. 9: 159-165, 1974 83. Liu, Y.Y., Schmeltz, I., and Hoffmann, D., Chemical studies on tobacco smoke. XXVII. Quantitative analysis of hydrazine in tobacco and cigarette smoke, Anal. Chem., 46:885-889, 1974 4/84. Hoffmann, D., Sanghvi, L.D., and Wynder, E. L. Chemical studies on tobacco smoke. XXVIII. Comparative chemical analysis of Indian bidi and American cigarette smoke. Int. J. Cancer, 14:49-53, 1974 /18,5-. Hecht, S.S., Bondinell, E.W., and Hoffmann, D. Chemical studies on tobacco smoke. XXIX. Chrysene and methylchrysenes: Presence in tobacco smoke and carcinogenicity. J. Natl. Cancer Inst., 53:1121-1133, 1974 t" 86 . INof fmar.r., D., Hecht, S. S. , Ornaf, R. M. , and Wynder, E. L. Chemical studies on tobacco smoke. XXX. N'-Nitroso- nornicotine in tobacco. Science, 186:265-267, 1974 1-87. Kobayashi, N., Hoffmann, D., and Wynder, E.L. A study of tobacco carcinogenesis. XII. Epithelial changes induced in the upper respiratory tracts of Syrian Golden hamsters by cigarette smoke. J. Natl. Cancer Inst., 53:1085-1089, 1974 ~ 88. Schmeltz, I.,Hoffmann, D., and Wynder, E.L. Chemical studies on tobacco smoke. XXXII. Toxic and tumor- igenic agents in tobacco s.::c-e: Analytical methods and modes of origin. Proc. 8. Ann. Conf. Trace Substances in Er_vi ron*n.ueai th. 281-2°.5, 1974 ~ 89. Brunnemann, K. D. , and Fioffmann, D. Chemical studies on tobacco smoke. XXXIV. Gas chromatographic determination of ammonia in cigarette and cigar smoke. J. Chrom. Sci., 13:157-163, 1975 ~90. Hecht, S. S. , Ornaf, R. P•1. ,a^2 ?'.cf-:-:ar.^_, D. , Chemical studies on tobacco s-:o::e. Xr:XIII. *''-Nitrosonorni- cotine in tobacco: Analysis of possible contributing factors and biologic implications. J. Natl. Cancer _Inst., 54:1237-1244, 1975

10. - 91. Hoffmann, D., and Wynder, E.L. Positive controls in environmental respiratory carcinogenesis. In Carcinogenic Testing of Chemicals. L. Goldberg, ed., Cleveland, Ohio: CRC Press, 1974, pp. 35-39 ; 92. Wynder, E. L. and Hoffmann, D. The tenth anniversary of the Surgeon General's report on smoking and health: Have we made any progress? Guest Editorial. J. Natl. Cancer Inst., 54:533-534,1975 V-93. Schmeltz, I., de Paolis, A., and Hoffmann, D. Chemical 8tudies cn tobacco smoke. XXXI. Phytosterols in tobacco: Quantitative analysis and fate in to- bacco combustion. Beitr. Tabakforsch. 8:211-218, 1975 (/ 94. Schmeltz, I., Hoffmann, D., and Wynder, E.L. The influence of tobacco smoke on indoor atmospheres._ I. An overview. Prev. Med. 4:66-82, 1975 -"'95. Hoffmann, D., Raineri, R., Hecht, S.S., Maronpot, R.R., and Wynder, Effect basine 1975 E.L. A study of tobacco carcinogenesis. XIV. of N'-nitrosonornicotine and N'-nitrosoana- in rats. J. Natl. Cancer Inst. 55:977-981, ~ 7 96. Vynder, E.L., rlabuchi, K., and Hoffmann, D. "Tobacco" In "Cancer feld. Epidemiology and Prevention", ed. D. Schotten- Charles C. Thomas Publ., Springfield, Ill., pp. 102-125, 1974 '' 97. Hec^t, S.S., Thorne, R.~IaronpoL and Hoffmann,D.A study of tobacco carcinogenesis. XIII. Tumor promoting subfractions of the weakly acidic fraction. J. Natl. Cancer Inst. 55:1329-1336, 1975 98. Sc :-Lmeltz, I. , Tosk, J. , Jacobs , G. and fioffmann, D. Chemical Studies on Tobacco Smoke XXXV The Redcx Potential and Quinone Content of Cigarette Smoke. r.r_al. 49 : 1924-1929, 1977 99. Hecht, S. S. , Ornaf, R. M., and Hoffmann, D. Determination of N'-nitrosonornicotine in tobacco by high speed liquid chromatography. Anal. Chem. 47: 2046-2048, 1975 Eo=fr.ann, D. , Patrianakcs, C.?. , BrLr.n:e7w :,r. R. D. , and Gori, G. B. Chemical studies on tobacco smoke. XXXVI. Chromatographic ceterm.ination of vinyl crilori6e in tobacco smoke. Anal. Chem. 48:47-50, 1976 T N N N w N N

11. 101. Brunnemann, K.D., Hoffmann, D., Wynder, E.L., and Gori, G.B. Chemical studies on tobacco smoke. XXXVII. Determina- tion of tar, nicotine, and carbon monoxide in cigarette smoke. A comparison on international smoking conditions. In "Smoking and Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. pn Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U. S. Governmt. Printing Office, Washington, D.C. 1976,441-44g, 102. Schmeltz, I., and Hoffmann, D. Chemical studies on tobacco smoke. XXXVIII. The physico-chemical nature of cigarette smoke. In " Smoking and Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. and Health. (E.L. Wynder, D. Hoffmann and G. U. S. Governmt. Printing Office, Washington, on Smoking B. Gori,eds.) D.C. 1976,13-34. ~ 103. Hoffmann, D., Schmeltz, I., Hecht, S.S., and Wynder, E.L. Chemical studies on tobacco smoke. XXXIX. On the identification of carcinogens, tumor promoters, and co- carcinogens in tobacco smoke. In "Smoking and Health: , I. Modifying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U. S. Governmt. Printing Office, Wash- ington, D.C. 1976, 125-145. 104. Hecht, S.S., Schmeltz, I., Hoffmann, D., and Wynder, E.L. Chemical studies on tobacco smoke. XL. Identification of carcinogens in tobacco. In "Smoking and Health: I. Modi- fying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann, and G. B. Gori, eds.) U.S. Governmt. Printing Office, Washington, D. C. 1976, 191-202. 105. Hoffmann, D. and Wynder, E.L. Selective reduction of tumor- igenicity igenicity of tobacco smoke. III. The reduction of polynuclear aromatic hydrocarbons in cigarette smoke. In "Smoking and Health: I. Mcd4fv_na the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gori, eds.) U.S. Governmt. Printing Office, Washington, D.C. 1976,495-504. 106. ' Hecht, S.S., Tso, T.C. and Hoffmann, D. Selective reduction of tumorigenicity of tobacco smoke. IV. Reduction of N-nitrosa.mines and aromatic a::,ines. In "Smoking and ~ Health: I. Modifying the Risk for the Smoker". Proc. Third World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. B. Gcr_, eds.) L'.S. Governmt. Print- N N ~ ing Office, Washir,gton, D. C. 19?6 , 535-5n5. ~ tJ 107. Tso, T.C.,Gori, G.B., and Hoffmann, D. Reduction of nicotine and tar in tobacco and in cigarettes through agricultural techniaues. In "Smoking and Health: I. Modifying the Risk for the Smoker" . Proc. Triird World Conf. on Smoking and Health. (E.L. Wynder, D. Hoffmann and G. P,. Gori, ec+s.) U. S. Governmt. Printing Office, Washington, D.C. 1976, 35-48.

12. 108. Hoffmann, D., Brunnemann, K.D., Gori, G.B., and Wynder, E.L. On the carcinogenicity of marijuana smoke. Recent Advanc. Phytochem. 9:63-81, 1975 109. Hoffmann, D.,Hecht, S.S., Ornaf, R.M. Tso, T.C., and Wynder, E.L. N'-Nitrosor.ornicotine: Presence in Tobacco, Formation and Carcinocenicity. Chemical studies on tobacco smoke. XLII. Int. Agency Res. Cancer ~ Publ. Monog. 14:307-320,,1976 ~ 1 Hoffmann, D. and Wynder, E.L. Chemical studies on tobacco sr<<oke XLIII. The Active Fractions of Cigarette Smoke in Experimental Tobacco Carcinogenesis. A Review. Tobacco Res. 1:88-97, 1975 111. Hoffmann, D., Hecht, S.S., Schmeltz, I., Brunnemann, K.D. ~ and Wynder, E. L. Chemical Studies on tobacco smoke. XLIV. New separatinn techniques for classes of smoke compounds. Rec. Adv. Tob. Sci. 1, 97-122, 1975. --'fl2. Schmeltz, I. and Hoffmann, D. Formation of Polynuclear Aromatic Hydrocarbons from Combustion of Organic Matter. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 225-239, (R.I. Freudenthal and and P. W. Jones, eds.), Raven Press, New York, 1976 ~ 113. Hecht, S.S., Loy, M. and Hoffmar.r., D. On the Structure and Carcinogenicity of the Methyl- chrysenes. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 325-340 (R.T_. Freudenthal and P.W. Jones, eds.), Raven Press, New York 1_14. J Brunnemann, K.D. and Hoffmann, D. Analysis of Polynuclear Aromatic Hydrocarbons in the Respiratory Environment. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, pp 283-297, (R. I• w r:d P.T.:. Jones, eclls. ), Raven Press, New York, 1976 i 115. Sc: .:,eltz, I., Brunnemann, K. D. , Hof fmann, D. and Cornell, A. Chemical Studies on Tobacco XLV. On the chemistry of cigar smoke: Ccmparisons between experi- mental little and large ciaars. Beitr. Tabakforsch, 8: 367-377, 1976. v' 116. Schmeltz, I., Tosk, J. and :?orf-:a^_n, D. Chemical Studies c- =ohacce XL711'7. Formation and determination of naphthalenes in cigarette smoke. Anal. Chem. 48: 645-650, 1976 117._' Hecht, S.S., Chen, C.B. and Hoffmann, D. ~ Synthesis of N-nitrosamino aldehydes. Tetrahedron Letters. No.8, 593-596, 1976

13. 118. Hoffmann, D. and Wynder, E.L. Smoking and occupational cancers. Prevent. Med.5; 245-261, 1976 - 119. Wynder, E.L., Hoffmann, D., Chan, P. and. Reddy, B. Interdisciplinary and Experimental Approaches: Metabolic Epidemiology in "Persons at High Risk of Cancer, An Approach to Cancer Etiology and Control, pp. 485-501, (J.F. Fraumeni, ed.) Academic Press, N.Y. 1975 1_20. Hecht, S.S., Loy, M., Maronpot, R.R. and Hoffmann, D. A Study of Chemical Carcinogenesis: Comparative Carcinogenicity of 5-Methylchrysene, Benzo (a) pyrene, and modified chrysenes. Cancer Letters 1, 147-154, 1976 v121. Schmeltz, I., Abidi, S. and Hoffmann, D. Chemical Studies on Tobacco Smoke. XLVIII. Analysis of tumorigenic agents in processed (unburned) tobacco: N-Nitrosodiethanola*r.ine and 1,1-dimethyl- hydrazine. Cancer Letters 2,125-132, 1977 ,(-'122. 123. Bru.^.nemann, K. D. , Yu, L. and Hof fmann , D. Chemical Studies on Tobacco Smoke.XLIX. Gas chromato- graphic determination of hydrogen cyanide in tobacco smoke. J. Anal. Toxicol., 1, 38-42, 1977. Wynder, E.L. and Hoffmann, D. Tobacco and Tobacco Smoke. Seminars in Oncology 1: 5-15, 1976 124. Hoffmann, D., Schmeltz, I., hecht, S.S. and Wynder, E. L. Volatile Carcinogens: Occurrence, Formation and Analysis. Detection and Prevention of Cancer. Part I, Vol. 2, Marcel Dec':er, 'New York (1978). pp. 1943-1959 17125. Scr-^eltz, I., Brunnemann, K. D. , Ho_`f mann, D. Analytical Methods for Polynuclear Hydrocarbons. Detection and Prevention of Cancer. Part I, Vol. 2, Marcel Decker (1978). pp. 1973-1992. Hoffmann, D., and b%,ynder, E.T. Organic Particulate Pollutants,Chemical Analysis and Bioassays for Carcino5enicity in: "Air Pollution", 3rd Edition. (Arthur C. Stern ed.), Vo1.II, PartB, pp 361-455 Academic Press.~I. Y. 1977

14. 127. Schmeltz, I. and Hoffmann, D. Chemical Studies on Tobacc^ Smo}.e L. Nitrogen=Containing Compounds in Tobacco ar.d Tobacco Smoke. Cher... =.ev., Vol. 77, 295-311,1977 .~128. Brunnemann, K.D., Lee, H.C., and Hoffmann, D. Chemical Studies on On the Quantitative Tobacco Analysis Smoke. XLVII. of Catechols and their Reduction. Anal. Letters, 9, 939-955, 1976. ~/1.29. Hilfrich, J., Hecht, S.S. and Hoffmann, D. A Study of Tobacco Carcinocenesis Effects of N'-Nitrosonornicotine Nitrosoanabasine in Syrian Golden XV. and.P?'- Hamsters. Cancer Letters, 2:169-176, 1977. (~'130. Dong, M., Locke, D.C. and F-'offl-.ann, D. Separation of Aza-Arenes by High Pressure Liquid Chromatography, J. Chromat. Sci., 15:32-35, 1977. v 131. :Ioffmann, D., Dong, M., and Hecht, S.S. Chemical Studies on Tobacco Smoke LII. Origin_in Tobacco Smoke of N'-Nitrosonornicotine, A Tobacco-Specific Carcinogen: Brief Communication. J. Natl. Cancer Inst. .SL: 1841-1844, 1977. 132. Weiss, L., Loy, M., Hecht, S.S., and uoffmann, D. r Study of Chemical Carcinocenesis. IV. Synthesis of the carbor.-14 labelled carcinogens :,-:let: ylchrysene, t_ ~.._llne, and 3-nethyl-2- naphthylamine. J. Labelled Cp6s. and Radiopharma- ceuticals, 1977, in T_-ess. L~ 133. Donc, M., Locke, D.C. and HoTfT.ann, D. Characterization of Aza-Arenes in the basic Organic Portion of Suspended Particulate Matter. Environ. Sci. and Techn. 11: 612-518, 1977. 134. L'=_, .-i., 'ioffmann, D., S:-:ort Cor.-munication: =^a Jcc•_:Y-er.ce of Caffeine ttm.. Environ., 11, pp 651-653, 1977.

15. 135. Hoffmann, D., Schmeltz, I., Hecht, S.S., and Wynder, E.L. Polynuclear Aromatic Hydrocarbons in Tobacco Carcino- genesis. In"Polycyclic Hydrocarbons in Cancer: Chemis- try, Molecular Biology and Environment." (H. Gelboin and P.O.Ts'o, eds.) Academic Press. in print ";'136. Hecht, S.S., Loy, M., Mazzarese, R., and Hoffmann, D. On the Carcinogenicity of 5-methylchrysene: Structure- Activity Studies and Metabolism. Proc. U.S.-Japan Cooperative Cancer Res. Program, New Orleans, La., Jan., 1977. ____137. Hecht, S.S., Chen, C.B., Dong, M., Ornaf, R.M., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LI. Studies on Non-Volatile Nitrosamines in Tobacco. Beitr. Tabakforsch. 9: 1-6, 1977. ~' 138. Hecht, S.S., Chen, C.B. and Hoffmann, D. ' A Study of Chemical Carcinogenesis VI. Nitroso- pyrrolidine Carcinogenesis: Evidence for Metabolic a-Hydroxylation. Cancer Res. 38: 215-218, 1978. L139. Brunnemann, K.D., Yu, L., and Hoffmann, D. Assessment of Carcinogenic Volatile N-Nitrosamines in Tobacco and in Mainstream and Sidestream Smoke from Cigarettes. Cancer Res. 37, 3213-3222, 1977. %- 140. t..yr_der, E.L. and Hoffmann, D. Tobacco and Health: A Societal Challenge. Scientific American ~ 141. Hecht, S.S., Chen, C.B., Ornaf, R.M., Jacobs, E., Adams, J.D. and Hoffmann, D. Chemical Studies on Tobacco S:-:.o3-e LVIT.* Reaction of Nicotine and Sodium r:itrite: Formation of Nitrosamines and Fragmentation of the Pyrrolidine Ring. J. Org. Chem. 43, 72-75, 1978. 142. Schmeltz, I., Wenger, A., Hoffmann, D. and Tso, T.C. Che-.ical Stuc:ies on Tohaccc Use of' Radioactive Tob3cco Isolates for Studying the Formation of Smoke Components. J. Agr. Food Chem., in press. 143. Dong, M., Schmeltz, I. and Hoffmann, D. Purification of Quinolines for Bioassay by Preparative High Pressure Liquid Chromatography. J. Chromatogr., "Pub1- lists No. LII in error.

16. 144. 145. 146. ~ 147. 148. 149. l 150. .; 151. Brur_nenz.nn, K.D.B. and Hoffmann, D. Chemical Studies on Tobacco Smoke LIX Analysis of Volatile Nitresamines in Tobacco Smoke and Polluted Indoor Environments. IARC Sci. Publ. In press Dong, M., Schmeltz, I., Jacobs, E. and Hoffmann, D. Chemical Studies on Tobacco Smoke LV. Aza-Arenes in Cigarette Smoke. J. Ana.l._Tocicol. In press. Hecht, S.S., Chen, C.B., Hoffmann, D. and Tso, T.C. Chemical Studies on Tobacco Smoke LVI Tobacco Specific Nitrosamines: Origins, Carcinogenicity and Metabolism. IARC Sci. Publ. _Tn press. Hilfrich, J., Schmeltz, I., and Hoffmann, D. Effects of N'-nitrosodiethanolamine and 1,1-diethanolhydrazine in Syrian Golden Hamsters., Cancer Letters, In press. Toth, B., 6"lallcave, L., Patil, K.,Schmeltz, I., and Hoffmann, D., Induction of Tumors in Mice with the Herbicide Succinic Acid 2,2-Dimethylhydrazide. Cancer Res. 37, 3497-3500, 1977 Hecht, S.S., Schmeltz, I. and Hoffmann, D. -Chemical Studies on Tobacco Smoke LVIII. Nitrogenous Compounds in Cicarette Smoke and Their Possille Precursors. Rec. Adv. Tob. Sci., 3, 59-63, 1977. Hecht, S.S., Loy, M., Mazzarese, R., and Hoffmann, D., A Study of Chemical Carcinogenesis 7. Synthesis and rlutagenicity Of riodified Chrysenes Related To The Carcinogen, 5-Yethylchrysene. J. Med. Chem 21, 38-44, 1978. - Hecht, S.S, Hirct , _:. , -c_ , --. ---.. --c=f,.:ann, D. A Study Of C:^e_._-cal Carc`_::c -.`.._s 8. Tumor Initiating Activity of Fluorinated 5-Methyl- chrysenes. SuLmitted.

17. 152. Brunnemann, K.D., Adams, J.D., Ho, D.P.S. and Hoffmann, D., The Influence of Tobacco Smoke on Indoor Atmospheres 'II. Volatile and Tobacco-Specific Nitrosamines in Main- and Sidestream Smoke and Their Contribution to Indoor Pollution. Proc. 4th Joint Conf. on Sensing of Environm. Pollutants, New Orleans, La, 1977, in press. 153. SChmeltz, I, Tosk, J, Hilfrich, H, Hirota, N., Hoffmann, D. and Wynder, E.L., Bioassays of Naphthalene and Aikylnaphthalenes for Cocarcinogenic Activity. Relation to Tobacco Carcinogenesis. "Polynuclear Aromatic Hydrocarbons". Vol. 2 (Jones and Freudenthal, eds). Raven Press. In print ' 154. Dong, M., Schmeltz, I., LaVoie, E. and Hoffmann, D. Aza-Arenes in the Respiratory Environment: Analysis and Assays for `?utagenicity.In "Polynuclear Aromatic Hydrocarbons." Vol. 2 (Jones and Freudenthal, eds) Raven Press. In print 155. Hoffmann, D. and Wynder, E.L. The Less Harmful Cigarette: Present and Future World Smoking and Health, Vol. 2. No. 2 pp 30-34 (Amer. Cancer Soc.) 1977 156. Hoffmann, D. and Wynder, E.L. Identification and Reduction of Carcinogens in the Respiratory FnvironT.ent. Zentralbl. Ba':t. Hvg. I. Abt. Orig. B. 544 888 - (1977) 157. Hecht, S.S., Carmella, S. and Hoffmann, D. Chemical Studies on Tob-acco Smoke LIV. Determination of Hydroxyber_zyl Alcohols and I'.ydroxyphenyl Ethanols in Tobacco and Tobacco S:r,oke. J. Anal. Toxiccl. Sub:,,_`t-led. 158. Hoffmann, D., Hecht, S.S., Schmeltz, I. and Wynder, E.L. Polynuclear AroT-:ati c H'.dYocar1D o=~s : Occurrence, Formation and Carcinogenicity. Proceedings of the Symposium "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD. August, 1977. 159. Schmeltz, I., Hoffmann, D. and Toth, B. Hydrazines: Occurrence, Analysis and Carcinogenic Activity as related to Structure. Proceedings of the Symposium "Structural Correlates of Carcinogenesis and Mutagenesis: A Guide to Testing Priorities." FDA, Annapolis, MD. August, 1977.

18. 160. Hoffmann, D., Rivenson, A., Hecht, S.S., Hilfrich, J., Kobayashi, N. and Wynder, E.L. Model Studies in Tobacco Carcinogenesis with the Syr-an Golden Hamster. Progr. Exptl. Tumor Res. = ^rint. ,_~,.7.61. Hecht, S.S., Chen, C.B., Hirota, N, Ornaf, R.M., Tso, T.C. and Hoffmann, D. A Study of Tobacco Carcinogenesis, XVI Tobacco Specific Nitrosamines: Formation from Nicotine in vitro and during Tobacco Curing and Carcinogenicity in Strain P_P1ice. J. Natl. Cancer Inst. In Pre--s. -, v& o ",,/ 1+;. / iy?~; / d'i 1~-~a 5/. 162. Wynder, E. ~. ,iio fmann, D. ,:IcCoy, G. D. , Cohen, L.A. and Reddy, B.S. Tumor Promotion and Cocarcinogenesis as Related to Man and His Environment. In "Carcino- genesis", Vol. 2. "Mecnanisms of Tumor Promotion and Cocarcinocenesis. (T.J. Slaga, A. Sivak, and R.K. Bont%eell, eds. ) P.aven Press, New Yor?-, 1978. In print. ~ 163. Hecht, S.S., LaVoie, E., Mazzarese, R., Shantilal, A., Bedenko, V., and Hoffmann, D.. 1,2,-Dihydro-1,2-dihydrocy-5- methylchrysene, a Major Activated Metabolite of the Environmental Carcinogen, 5-I,4ethylchrysene, Cancer Research