Tobacco Documents Online

BI BL I OGRAPHY Dietrich Hoffmann, Ph.D. Wynder, E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. VII. The Role of Higher Polycyclic Hydrocarbons. Cancer 12: 1079-1086, 1959. ^ . 1--'2. Wynder, E.L. and Hoffmann, D. The Carcinogen1city of Benzofluoranthenes. 11~!~-1199, Nov.-Dec. 1959. 7 3. Cancer 12: Wynder, E.L. and Hoffmann, D. Tobacco Smoking as a Cause of Cancer. Cancer Progress, Butterworths, London, Vol. 1°60, pp. 77-80. /4. Hoffmann, D. and Wynder, E.L. Short-Term Determination of Carcinogenic Aromatic Hydrocarbons Anal. Chem. 32: 295, February 1960. 5. Wynder, E.L. and Hoffmann, D. Some Practical Aspects of the Smoking-Cancer Problem. New Engl. J. Ned. 262: 540-545, March 1960. v 6. Ilofflnann, D. and Wynder, E.L. On the isolation and Identification of Polycyclic Aromatic Hydrocarbons. Cancer 13: 1062-1073, September-October, 1960. `~7 - W ynder, E.L. and Hoffmann, D. Present Status of Laboratory Studies on Tobacco Carcinogenesis Acta Pathol. Microbiol. Scand. 52: 119-132, Fasc. 2, 1961. ~ 8. 'Biekert, E., Hoffmann, D., and Meyer, F.J. Uber 1.4-Oxazine, I. Chem. Ber. 94: (6), 1676-16E'2, 1961. "2 9. Biekert, E., Hoffmann, D. and Meyer, F.J. Uber 1.4 Oxazine, II. Chem. Ber. 94: (6), 1676-16'.2, 1961. ~ 10. Hoffr,ann, D. and Wynder, E.L. A Study of Air Pollution Carcinogenesis. II. The Isolation and Identifi cation of Poivii:iclear iiro:lat-ic H11CGrocdrhoI7:; from Gasoline Engine Exhaust. Cancer ^15: 93-102, Januar.y-. February, 1962. __111. Wynder, E.L. and Hoffmann, D. #I A Study of Air Pollution Carcinogen~,sis. III. Carcinogenic Activity of Gasoline Engine Exhaust Tar. Cancer 115: 103-108, January-February, 1962. 81211302

2. -1"12. Hoffmann, D. and Wynder, E.L. Die quantitative Bestimmung von Phenolen im z-`~13. W ynder, Tabakrauch. Beitr. Tabakforsch. 1:101-106, August 1961. E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. VIII, The Role of the Acidic Fractions as Promoters. Cancer 14: 1306-1315, November-December 1961. ~ 14. Biekert, E., Hoffmann, D. and Enslein, L. Ueber 1.4 Oxazine IV. Kondensation von 1,2-Amino- alcoholen mit Ketocarbons3ureestern zu 5,6-Dihidroxy- 1.4-Oxazinonen (2). Chem. Ber. 94: (10) 2778-2785, 1961. P--'15. Wynder,- E.L. and Hoffmann, D. Carcinogenicity of Dibenzo(a,l)pyrene. Nature (London) 192: 1092-1093, 1961. Hoffmann, D. and Wynder, E.L. Analytical and Biological Studies on Gasoline Engine Exhaust. Natl. Cancer Inst. Monograph 9:91-116, 1962. "'l 7. Hoffmann, D. and Wynder, E.L. /. . ~ Filtration of Phenols from Cigarette Smoke. J. Natl. Cancer Inst. 30: 67-84, January, 1963. 117a. Holffmann, D. and Wynder, E.L. Die Filtration von Phenolen aus Cigarettenrauch. Beitr. Tabakforsch. 2:51-66, June 1963. 18. Hoffmann, D. and Wynder, E.L. Studies on Gasoline Enc~ine Exhaust. J. Air Pollutio:, Control Assoc. 17: 322-327, July 1963. "The Role of Skin I:eopiasia in To:-acco Carcinogenesis. In: "Tobacco And Health" (G.G. James and R. Rosenthal, eds.) pp. 61-7=. C.C. :cas, Sa- i^gfield, Illinois. V"19. W ynder, E.L. and Hoffmann, D. 20. Wynder, E.L. and Iloffmann, D. W N Air Pollution and Lung Cancer. ZV Proc. Natl. Conf. Air Pollution, pp. 143-148, 1963. N w 21. 1ioffmann, D., Rathkamp, G., and Wynder, E.L. G~„~, Comparison of the Yields of Several Selected Compor~ nts in the Smoke from Different Tobacco Products. J. Natl. Cancer Inst. 31: 627=637, September 1963. n

3. t-"21a. Hoffmann, D., Rathkamp, G., and j,7inder, E.L. Vergleich der AuL;beute an mehreren ausgew3hlten Komponenten im Rauch verschiedener Tabakerzeugnisse. I3eitr. Tabakforsch. 2:123-130, February 1964. 1-"22. Wynder, E.L. and Hoffmann, D. Ein Experimenteller Beitrag zur Tabakrauchkanzero- genese. Deut. Yed. .•7ochschr. 88: 623-628, March ~ 1963. 1,'~23. ~` Wynder, E.L., Kaiser, H.E., Goddman, D.A., and Hoffmann, D. A method for Determining Ciliastatic Components ' in Cigarette Smoke. Cancer 16:1222-1225, September + 1963. ~ - --., 24. Wynder, E.L. and Hoffmann, D. Experimental Aspects of Tobacco Carcinogenesis. Diseases Ches. 44: 337-346, October 1963. ~ 25. c•Jynder, E.L. and Hoffmann, D. Experimental Tobacco Carcinogenesis. in Cancer Res. 8: 249-453, 1964. Advances 26. Wynder, E.L. and Hoffmann, D. Reduction of Tumoricenicity of Cigarette Smoke. J. Am. Med. Assoc. 192: 88-94, April 12, 1965. /27. Hoffmann, D., Theisz, E., and ;vynder, E.L. Studies on the Carcin^genicity of Gasoline Exhaust. J. Air. Pollution Control Assoc. 15: 162-165, April 1965. (/28. -~•:ynder, E.L. and Ho_=:-:iar.n, D. Some Laboratory and E,piderniological Aspects of Air Pollution Carcino~;er,esi:~ .. J. Air Pollution Control Assoc. 15:155-'_59, April 1965. v 29. 1'Iyndej7, W.L., Goodman, D.A. and ?:offmar.n, D. Ciliatoxic Co,-.ponents in Cigarette Smoke. II. Carboxylic Acids and t,ic3enydes. Cancer 1£3:505-509, --'~'3 0 Wynder April 1965. and Hoffmann A D E Goodman L D . , , ., , . . ., . I A Ciliatoxic Components in Cigarette Smoke. III. P N In Vitro Comparison of Different Components. N Cancer 18: 1652-1658, 1965. W ' O ~ . 31. Wynder, E.L. and Hoffmann, D. Current concepts of environmental Cancer Research. ' Med. Clin. N. Am. 50:631-650, 1966.

4. ~ 32. Hoffmann, D. and Wynder, E.L. Beitrag'zur carcinogenen Wirkung von Dibenzpyrenen. Z. Krebsforsch. 68: 137-149, 1966. 7 33. wynder, E.L. and Hoffmann, D. Beziehungen zwischen Epidemiologie und experimenteller Kanzerogenese. rluench. Med. Wochschr. 108:1501-1512, 1966. ~/34. Hoffmann, D. and Rubin, J. '. '. Chemical Studies on Tobacco Smoke. I. The QLa nfitative Determination of indoles in Cigarette Smoke. Beitr. Tabakforsch. 3:409~414, 1966. ~35. Hoffmann, D., Rathkamp, G. and Rubin, J. Chemical Studies on Tobacco Smoke. II. Comparison of the Yields of Several Selected Components in the. Smoke from Five Major Turkish Tobacco Varieties.~ Food. Cosmet. Toxicol. 5:37-38, 1967. VI 36. Hoffrnann, D, and Wynder, E.L. The Reduction of the Tumorigenicity of Cigarette Smoke Condensate by Addition of Sodium Nitrate to Tobacco. Cancer Res. 27:7.72-174, 1967. 1? 37. Wynder, E.L. and Hoffmann, D. -~38. "Nutrition and Cancer". In: (R.W. Raven and F.J.C. Roe, woths, London, 1967. SAJhnder, E.L. and Ho_fmann, D. "The Prevention of Cancer" eds.) pp. 11-18; Butter- "Tobacco And Tobacco Smo';e. Studies in Experimental Carcinogenesis". Acadernic Press, 730 pp. New York 1967, '~39. b•lynder, E.L., Taguchl , K., Baden, V., and Hoffmann, D. A Study in Tobacco Carclno~.~;renesis. IV. The Effect of Cigarette Smoke on the Respiratory Tract of rlice ' After Passive Inha?ation. Cancer 21, 134-153, 1968. U. ---4 Ho_ffmann, D., and ;•Jynder, E.L. Chemical Analysis and Carcinogenic F3ioassay~i of Organic Particulate Pollutants. Chapter 20, Vol. II in Air Pollution. Ed. A.C. Stern. 187-247, Academic Press, New York, 1968.

5. ~ 41. Wynder, E.L. and Hoffmann, D. Selective Laboratory "•7ethods in Tobacco Carcino- genesis in Vol. IV "Nethods in Cancer Research" Ed. H. Busch. 3-52, Academic Press, New York, 1968. V"42. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke. III. Primary and Secondary Nitroalkanes in Cigarette Smoke. Beitr. Tabakforsch. 4(3):124-134, 1968. 43. v Hoffmann, D. and Wynder, E.L. Selective Reduction of the Turnorigenicity of Tobacco Smoke. Experimental Approaches. Monogr. Natl. Cancer Inst. 28:151-172, 1968. 1/44. Hoffmann, D. and Woziwodzki, H. Chemical Studies on Tobacco Smoke. IV. Free Nonvolatile Fatty Acids in Tobacco and Cigarette Smoke. Beitr. Tabakforsch. 4(4):167-175, 1968. ,~45. Hoffmann, D. and Rathkamp, G. Checmical Studies on Tobacco Smoke. V. Quantitative Determination of Chlorinated Hydrocarbon Insecticides in Cigarette Tobacco and Its Smoke. Beitr. Tabakforsch. 4(5):201-214, 1968. ,/- 46. Wynder, E.L. and Hoffmann, D. -47.~ Wynder, Ex;Derimental Tobacco Carcinogenesis. Science 162:862, Nov. 22, 1968. E.L. and Hoffmann, D. ''Bioassays in Tobacco Res. 11:163-193, 1968. Carcinogenesis". Progr. Tumor c-,-48. HOffmann, D. , Masuda, Y. a 1d 'r'l j:der, E.L. Chemical Studies on Tobacco Smoke. VII. a-Naphthylamine and 13-Naphthylamine in Cigarette Smoke. Nature 221:254- 256, 1969. v49 . Hoffmann, D., Rathkamp , G. and Woziwodzki, H. Chemical Studies on Tobacco Smoke VI. Quantitative Determination of Carbazoles in Cigarette Smoke. Beitr. Tabakforsch. 4(6):253-263, 1968. V"5J. *aasuda, Y. and Hoffnann, D. Chemical Studies nn Tobacco Smoke. VII. Quantitative Determination of 1-Naphthylamine and 2-Naphthylamine in Cigarette Smoke. Anal. Chem. 41:650-652, 1969.

6. ~ 51. Wynder, E.L. and Hoffmann, D. Current Studies in Etiology and Prevention. In "Lung Cancer: A Study of 5,000 Memorial Hospital Cases". Ed. W.L. Watson, C.V. Mosby ComD. St. Louis, Mo., 15-34, 1969. 52. Hoffmann, D., Rathkamp, G. and Nes=:7, S. Chemical Studies on Tobacco Smoke. VIII. Quantitative Determination of 9-Methylcarbazoles in Cigarette Smoke. Anal. Chem. 41:1256-1259, 1969. z'~53. Wynder, E.L. and Hoffmann, D. A Study of Tobacco Carcinogenesis. X. Tumor Promot4-ng Activity. Cancer 24:289-301, 1969. ,,,54. Hoffmann, D., Rathkamp, G. and .lynder, E.L. Chemical Studies on Tobacco Smoke. IX. Quantitative Analysis of Chlorinated Hydrocarbon Insecticides. Beitr. Tabakforsch. 5:140-148, 1969. 1--55. Masuda, Y. and Hoffmann, D. A Method for the Determination of Primary Amines of Polynuclear Aromatic Hydrocarbons. J. Chromatog. Sci. 7:694-697, 1969. ,/ 56. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke. X. Quantitative Determination of 1-Alkylindoles in Cigarette Smoke. Anal. Chem. 42:366-370, 1970. ~ 57. Hofrmann, D. and Wynder, E.L. Chamber Development and Aerosol Dispersion. U.S. At. Energ. Symp. Ser. 18:173-191, 1970. ,, 58 Hoffmann, D. and Mazzola, V. Chemical Studies on Tobacco Smoke. XI. Dibenzofurans in Cigarette Smoke. Beitr. Tabakforsch. 5: 183-188,1970 ,--59. Hoffmann, D. and Rathkamo. G. Chemical Studies on Tobacco Smoke. XII. Quantitative Determination of Nitro'oenzenes in Cigarette Smoke. Anal. Chem. 42: 1643-1647, 1970 '~60. Wynder, E.L. and Hoffmann, D. The Eaidermis and the Tract as Bi oassa-v S•7stems in Tobacco Carc-__oc -_~_s. Brit. J. Cancer. 24: 574-587, 1970 ~ 61 . Ho f fmann , D. and TnTynde r, E. L. A Study of Tobacco Carcinogenesis. XI. Tumor Initiators.,.Cancer27: 848-864, 1971 62. Rath kamo, G. and Hoffmann, D. Chemical Studies on Tobacco Smoke. XIII. Inhibition of the Pyrosynthesis of Several Selective Smoke Constituents. Beitr. Tabakforsch.,5: 302-306, 1970

7. 1/53. Marquardt, H., Bendich, A., Philips, F.S., and Hoffmann, D. Binding of [G-3H]-7,12-Dimethylbenz[a]anthracene to DNA of Normal and of Rapidly Dividing Hepatic Cells in Rats. Chem.-Biol. Interaction, 3: 1-11, 1971 ~ 64. Hoffmann, D. and Wynder, E.L. Respiratory Carcinogens: Their Nature and Precursors. In: "Proc. Intern. Symp. on Identification and Measurements of Environ. Pollutants" (I. Hoffman, ed.) 9-16, Campbell Printing, Ottawa, Canada, 1972 - 65. Wynder, E.L. and Hoffmann, D. Carcinogens in the air. Proc. 24th Annual Symp. on Fundamen- tal Cancer Research, Houston, Texas, 118-138, 1972 v 66. Hoffmann, D. and Rathkamp, G. Chemical Studies on Tobacco Smoke, XIV. Quantitative Deter- mination of Fluorenes in Cigarette Smoke and their Formation by Pyrosynthesis. Anal. Chem., 44: 899-904, 1972 ,,~67. Hoffmann, D. and Wynder, E.L. Chemical Studies on Tobacco Smoke. XV. Chemical Composition and Tumorigenicity of Tobacco Smoke. In: "The Chemistry of Tobacco and Tobacco Smoke" (I. Schmeltz, ed.), 123-147, Plenum Press, New York, N.Y., 1972 6--'68. Wynder, E.L. and Hoffmann, D. Less Harmful Ways of Smoking. J. Nat. Cancer Inst., 48: 1749-1758, 1972 c. 69. Hoffmann, D. and Wynder, E.L. Selective Reduction of the T=origenicity of Tobacco Smoke.II Experimental Approaches. J. Nat. Cancer Inst., 48: 1855-1868, 1972 V70. Hoff::lann, D., Rathkamp, G., Nesnow, S., and Wynder, E.L. - Fluoranthenes: Quantitative Deter:mir:ation in Cigarette Smoke, Formation by Pyrolysis and Tumor Initiating Activity. J. IvTatl. Cancer Inst., 49: 1165-1175, 1972 t% 71. Hoffmann, D. and Wynder, E.L. Chemical Studies on Tobacco Smoke. XVIII. Smoke of Cigarettes and Little Cigars: An Analytical Comparison, Science, 178: 1197-1199, 1972 ~ 72. HoffmaZn, D. Benzo[a]pyrene in Polluted _~~4r. Prevent. Med., 1: 450- 451, 1972 1--'73. Liu, Y.Y., and Hoffmann, D. Chemical studies on tobacco smoke. XIX. nuantitative Chromatographic determination of maleic hydrazide in cigarette smoke. Anal. Chem., 45: 2270-2273, 1973

8. ~74. Rathkamp, G., Tso, T.C., and Hoffmann, D. Chemical studies on tobacco smoke. XX. Smoke analysis of cigarettes made from Bright tobaccos differing in variety and stalk positions. Beitr. Tabakforsch., 7: 179-189, 1973 - i ~/75. Tso, T.C., Rathkamp, G., and Hoffmann, D. Chemical studies on tobacco smoke. XXI. Correlation and multiple regresssion among selected cigarette-smoke constituents and leaf characteristics of Bright tobacco. Beitr. Tabakforsch., 7: 190-194, 1973 c-~76. Hoffmann, D., Rathkamp, G., Brunnemann, K.D., and Wynder, E.L. Chemical studies on tobacco smoke. XXII. On the profile analysis of tobacco smoke. Sci. Total Environ., 2: 151- 171, 1973 - 77. Hu, M.W., Bondinell, W.E., and Hof`mann, D. Chemical studies on tobacco smoke. XXIII. Synthesis of carbon-14 labelled myosmine, nornicotine, and N'-nitroso- nornicotine. J. Labelled Compounds, 10: 79-88, 1974 ~78. Hoffmann, D., Bondinell, W.E. and Wynder, E.L. Carcinogenicity of methylchrysenes. Science, 183: 215-216, 1974 L--79. L 80. Brunnemann, K.D. and Hoffmann, D. Chemical studies on tobacco smoke. XXIV. A quantitative method for carbon monoxide and carbon dioxide in cigarette and cigar smoke. J. Chrom. Sci., 12: 70-75, 1974 Brunnemann, K.D., and Hoffmann, D. Chemical studies on tobacco smoke. XXV. The pH of tobacco smoke. Food. Cosmet. Toxicol., 12: 115-124, 1974 81. Hoffr^ann, D. and Wynder, V.L. 7 Environmental respiratorv carcinoaenesis. In: "Chemical Carcinogenesis" (Searle,lC.E., ed.), ACS Monograph, 173, American Chemical Society, Washingron, D.C. 324-365, 1976.

9. 82. Hoffmann, D., Rathkamp, G., and Liu, Y.Y. Chemical studies on tobacco smoke. XXVI. On the isolation and identification of volatile and non- volatile N-nitrosamines and hydrazines in cigarette smoke. Int. Agency Res. Cancer Publ., Monogr. 9: 159-165, 1974 83. Liu, Y.Y., Schmeltz, I., and Hoffmann, D., Chemical studies on tobacco smoke. XXVII. Quantitative analysis of hydrazine in tobacco and cigarette smoke, Anal. Chem., 46:885-889, 1974 4/84. Hoffmann, D., Sanghvi, L.D., and Wynder, E. L. Chemical studies on tobacco smoke. XXVIII. Comparative chemical analysis of Indian bidi and American cigarette smoke. Int. J. Cancer, 14:49-53, 1974 /18,5-. Hecht, S.S., Bondinell, E.W., and Hoffmann, D. Chemical studies on tobacco smoke. XXIX. Chrysene and methylchrysenes: Presence in tobacco smoke and carcinogenicity. J. Natl. Cancer Inst., 53:1121-1133, 1974 t" 86 . INof fmar.r., D., Hecht, S. S. , Ornaf, R. M. , and Wynder, E. L. Chemical studies on tobacco smoke. XXX. N'-Nitroso- nornicotine in tobacco. Science, 186:265-267, 1974 1-87. Kobayashi, N., Hoffmann, D., and Wynder, E.L. A study of tobacco carcinogenesis. XII. Epithelial changes induced in the upper respiratory tracts of Syrian Golden hamsters by cigarette smoke. J. Natl. Cancer Inst., 53:1085-1089, 1974 ~ 88. Schmeltz, I.,Hoffmann, D., and Wynder, E.L. Chemical studies on tobacco smoke. XXXII. Toxic and tumor- igenic agents in tobacco s.::c-e: Analytical methods and modes of origin. Proc. 8. Ann. Conf. Trace Substances in Er_vi ron*n.ueai th. 281-2°.5, 1974 ~ 89. Brunnemann, K. D. , and Fioffmann, D. Chemical studies on tobacco smoke. XXXIV. Gas chromatographic determination of ammonia in cigarette and cigar smoke. J. Chrom. Sci., 13:157-163, 1975 ~90. Hecht, S. S. , Ornaf, R. P•1. ,a^2 ?'.cf-:-:ar.^_, D. , Chemical studies on tobacco s-:o::e. Xr:XIII. *''-Nitrosonorni- cotine in tobacco: Analysis of possible contributing factors and biologic implications. J. Natl. Cancer _Inst., 54:1237-1244, 1975

10. - 91. Hoffmann, D., and Wynder, E.L. Positive controls in environmental respiratory carcinogenesis. In Carcinogenic Testing of Chemicals. L. Goldberg, ed., Cleveland, Ohio: CRC Press, 1974, pp. 35-39 ; 92. Wynder, E. L. and Hoffmann, D. The tenth anniversary of the Surgeon General's report on smoking and health: Have we made any progress? Guest Editorial. J. Natl. Cancer Inst., 54:533-534,1975 V-93. Schmeltz, I., de Paolis, A., and Hoffmann, D. Chemical 8tudies cn tobacco smoke. XXXI. Phytosterols in tobacco: Quantitative analysis and fate in to- bacco combustion. Beitr. Tabakforsch. 8:211-218, 1975 (/ 94. Schmeltz, I., Hoffmann, D., and Wynder, E.L. The influence of tobacco smoke on indoor atmospheres._ I. An overview. Prev. Med. 4:66-82, 1975 -"'95. Hoffmann, D., Raineri, R., Hecht, S.S., Maronpot, R.R., and Wynder, Effect basine 1975 E.L. A study of tobacco carcinogenesis. XIV. of N'-nitrosonornicotine and N'-nitrosoana- in rats. J. Natl. Cancer Inst. 55:977-981, ~ 7 96. Vynder, E.L., rlabuchi, K., and Hoffmann, D. "Tobacco" In "Cancer feld. Epidemiology and Prevention", ed. D. Schotten- Charles C. Thomas Publ., Springfield, Ill., pp. 102-125, 1974 '' 97. Hec^t, S.S., Thorne, R.~IaronpoL and Hoffmann,D.A study of tobacco carcinogenesis. XIII. Tumor promoting subfractions of the weakly acidic fraction. J. Natl. Cancer Inst. 55:1329-1336, 1975 98. Sc :-Lmeltz, I. , Tosk, J. , Jacobs , G. and fioffmann, D. Chemical Studies on Tobacco Smoke XXXV The Redcx Potential and Quinone Content of Cigarette Smoke. r.r_al. 49 : 1924-1929, 1977 99. Hecht, S. S. , Ornaf, R. M., and Hoffmann, D. Determination of N'-nitrosonornicotine in tobacco by high speed liquid chromatography. Anal. Chem. 47: 2046-2048, 1975 Eo=fr.ann, D. , Patrianakcs, C.?. , BrLr.n:e7w :,r. R. D. , and Gori, G. B. Chemical studies on tobacco smoke. XXXVI. Chromatographic ceterm.ination of vinyl crilori6e in tobacco smoke. Anal. Chem. 48:47-50, 1976 T N N N w N N