Tobacco Documents Online

/ (. L.r.f.a.'i~ ~ ~ CC7eLLCLa07CC/ -,'; Li I,~~ zd tr LL Cc4' iGa , TIK~,Cr,.ipnr a.u.orlv791 ~PF\a 1 .s-(!//-//I ~ 'C ~ta tll c-ec.:._,: Ct.L[C'X/b+/ Animal lodels and A te a d Long-Term Carbon - - Monoxide Intaxicationt NfdL'RICE STCPFEL,a' NfADELEI]E ;IORUELf i-DAfIBRIFE,e ~1 F AHDHE VAL2ELLEi AT'D ARTHCR PEFP_\\IOS' 'F.r.rh Scr4•.rn/ Irmlmrr n/Hrnlrh fl.\'S£RVr. 101 ru O )rA=5 Pn.rr Co4. Il F •Arrr - R A ef I CC :-- tC£F hl . . { - I-! P ••n e ' 7 d 5/ r.J•nlsP - F: vrl F 1\ ICrZ•• IRJr (,/rllll- ! aC\RZIFarr.r'JGr~•rruL+F.•.~n.r.:dJr• Fenr•r I \ Sna!I roE<nqar rhr k rr.als osr urllaed V rAe eSms of a: and Iu: prum carban manaclCe In:o.ica lons. TToe anirnaln•ont< uxd in uffmien[ nnmtmo InCro,. - calhaiErJr:a. culu.Fvnhemare-r!r]. ro}, erlde.pan ofurand -re- bLfe`Ionee.pe.orrranarma4ePOS+rnr.;uEie.crsr,rralsuleVUrmp<+<ranone _. Jrd e en:al c vr r n. Erlvn _:al tr - ofacwc ludorl Mor. drRerc-cr5 rcar<e ro ape. sr, pr<enanry-and adree,l farnn,:efrerercca In srrain,. Ld, ia re•p'raron parxne:<rs, sp+n of Lfr. carMu~emndoFl.~ A.•ssiaJen. <nd. yrn ezrPonrde Crodo2rlon. and d:cadun rhlllrms +usr ru rzlen n. r-l drrar nn hen cam - oC:Fe efirru eo rn!seu padrF re"aln oMained •ith 6R<rem a n,al n r . E.perir .,. n.nLeandammmn:rceeahaurrareorfeariueresforrtesa• - ~rcarMnmmrmle<-.r:tr orAer muc <omPon<nr5 that Cerntnure a ns\ for ho.nan hral:h. In order to inveslipate the risk of an eneironmenlal hazard to hea0h, ir is necessar) m consider epidemiolc_eical dam and e.perim,ental animal studies. ' Epidamiolo¢ical sludies, while sueeeslin^_ health hazards. are unable to separnle em'ironmcntaL occupational. socioeconomic- and other factors from genelic or chronobiolccical factors. The use of e\prrimcmal atimnls enaNes one to edecl a species and to conlrol- ~y aee and se\ and enrironn:en!al factors /tempcrzlure lichrinc, iz<..tincd er<.i. Howe.er. this selection of a species. and often a speci6_ homogeneous vrain, V- a- . diminishes the scope of such studies and renders esrr polalion to man difLcutl. in T_tu „ ~a- bnth the route of adminislration and dosece of tovic factors ~,ryK~H IyA . - - ACUTE TOXICITY Apart from the couraxeous selFe~perimentxtions of HzlAane and Krllick, zni- mals, initial!c mice and cacaries, were used to test the lo\icil. of high concentra- lions oCcarbon monezide- funSermore. lack of e1Tec1 of Ihis cas on plants /".Air Quali(p Crireria for Carben Slonoxidc, 1970-'1 and nsects /1) has Icd to its stvd7 on a ercat anetv of.enecra¢s. ' Pn :rd a a N'oASEep on Ca:h.n 1lenoclGe and Ca.Cro•a.Er:'ar Prea«. sponsmeC h rne Aon-n Hra!!n FnunEaJon ard rhe Federal tlel'h O:Gce Frt-rxl R.vuHic or Grrn:en.. 5nl,n. Ovo`.o 10-I]. 1978. ' To Som «S•-s,s for repnnu ehouW be adtrn<rd. - ~~rt .~~apr . 1 .. . I (.~in mcE.~~ . - ~G+-LU El.n... .rr le 9'C j-'- 1r'r.~2...