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Epidemiology School of Research Unit Public Health September 19, 1984 Pelayo Correa, M.D. Department of Pathology Louisiana State University Medical' Center 1901 Perdido Street New Orleans, LA 70112 The University of Texas Health Science Center at Houston P O Boa 20186 Houston, Texas 7702S (713) 792-46i i Dear Pelayo: ~ Thank you for your letter of August 21, 1984, regarding the proposal on passive smoking. I understand that the proposal must be submitted by October 15, 1984 and that the information you need from me at this point is (1) an expression of willingness to participate, and (2) a short description of the population to be included, estimated number of cases, facilities available, and a budget. Per our telephone conversation this week, I do wish to participate with you and the other investigators in the collaborative project proposed and am enclosing a written summary regarding the above. After we spoke I reviewed the Harris County lung cancer incidence data for 1976 to 1980 and population characteristics. Based on this review and our findings from the earlier lung cancer study in females, I estimate approximately 200-250 incident cases of lung cancer annually among female residents of Harris County in 1986 and 1987 and that 9% or 18-22 of them will be nonsmokers. These calculations suggest a total of 36-44 eligible incident cases from our area, ~ rather than the 9 per year (18 total). We will undoubtedly lose cases for the interview study due to underascertainment, inability to locate, refusals, etc. and' these losses should~ be considered from all areas in estimating the required sample size of study subjects with completed interviews. Perhaps we need to include cases for a third year. The information you requested is enclosed. Please do not hesitate to write or call if you need anything else. With very best regards. incerely, Patricia A. Buffter; P Professor of Epidemiology Enc (1) cc: Ms. Brenda Gehan Dr. Keith Burau