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Inhalation Bioassay of Cigarette Smoke in Dogs: Nicotine and Pmo Effects Borriston Project Number 317 Contract No. No1-Cp-55666

Date: 15 Jun 1981
Length: 372 pages
80402932-80403303
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Piccirillo, V.J.
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SCRT, SCIENTIFIC REPORT
CHAR, CHART/GRAPH/MAPS
DRAW, DRAWING
OUTL, OUTLINE
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80402932/80403303
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SPEARS/OFFICE
Named Person
Auerbach
Born
Dalgard, D.W.
Holman
Marmor
Mcgill
Rakitansky
Named Organization
Borr, Borriston Labs
Hazleton, Hazleton Labs
NCI, Natl Cancer Inst
Va Hospital
Battnw, Battelle Northwest
Recipient (Organization)
NCI, Natl Cancer Inst
Date Loaded
12 Feb 1999
Master ID
80402001/3325

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Borr, Borriston Labs
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CONF, CONFIDENTIAL
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G65
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pto40e00

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0 0 n . i a r k t 4 } )-r,.~: --.. . .,.i f y...~.'. . • . . ...,... •' . .,t : . . INHALATION BIOASSAY OF CIGARETTE SMOKE ~ IN DOGS: NICOTINE AND PMO EFFECTS BORRI'STON PROJECT #317 ~ + CONTRACT NO. NO1-CP'=55666 ~SUBMI'TT~EDT0:' NATIONAL CANCER INSTITUTE _ SMOKING AND'HEALTH PROGRAM ~ , SUBM'ITYED'BY: BORRISTON LABORATORIES, INC. June 15, 1981 k 01-8993536 ?^ S0&0'Beech Placa • Temple Hills, Maryland 200311 •
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CW': ~~L Rl1 I I I I I I . I I I 1 ( TABLE OF CONTENTS SUMMARY INTRODUCTION TEST ANIMALS AND~HUSBANDRY A'SSIGNMENT T&TREATMENT GROUPS SMOKE EXPOSURE TRACHEOSTOMY' TRAINING SMOKING PROCEDURES QUALITY CONTROL OF CIGARETTES AND SMOKE EXPOSURE CIGARETTE MAINTENANCE ANO CONDDTIDNI% CIGARETTE ANDlSMOKf ANALYSIS PULMONARY PHYSIOLOGY CLINICAL LABORATORY STUDIES HEMATOLOGY HEMOSTASIS CLINICAL CHEMISTRY QUA'LITY CONTROL TERMINAL STUDIES SCHEDULED SACRIFICES NECROPSY PATHOLOGY AND MORPHOMETRY TRA'CHEALUNG BRONCHIAL EPITHELIUM PULMONARY VASCULATURE SYSTEMATIC VASCULATURE AORTA REMAINING ORGANS' RESULTS~ HEMATOLOGY RBC„ HEMATOCRIT,ANDHEMOGLOBINWBC PAGE'. 1'~~
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•7JkYI ~~tJ p' rN TGA ir 11 #l jl~ 3 J1 11 f ~f II t I r ~: 0 . 9 TABLE OF CONTENTS (Continued) RESULTS (Cantinued)' PLATELETS HEMOSTASIS PLATELET ADHESIVENESS. PLATELET AGGREGATION SERUM PROT!EIN ELECTROPHORESIS CLINICAL CHEMI'STRY PULMONARY FUNCTION PHASE II1 SLOPE CLOSING'VQLUME N~ WASHOUT VITAL CAPACITIY' P A 0 2 AND PAC02 RAW'DATA AND FINA'L REPORT'STORA'GE TABLES TABLE 1 - TABLE 2 - TABLE 3 - TABLE 4 - TABLE 5 - TABLE 6 - APPENDICES APPENDIX T - APPENDIX 2 - APPENDIX 3 - APPENDIX 41. - APPENDIX 5 - APPENDIX: 6 - APPENDIX: 7 - APPENDIX 8 - APPENDI'X 9 - MEAN HEMATOLOGY VALUES. MEANIHEMOSTASIS VALUES MEAN ELECTROPHOP.ESI'S DATA MEA'N CLINICAL CHEMISTRY DATA' MEAN PULMONARY MEASUREMENTS GROSS NECROPSY FIiNDIiNGS SMOKE EXPOSURE SCHEDULE ADL-3I SMOKDNG MACHINE SMOKE DELIVERY SYSTEM, CIGARETTE AND SMOKE ANALYSIS HEMATOLOGY, DATA PLATELET ADHESIVENESS AND AGGREGATION SERUMiPROTEIN ELECTROPHORESIS CLINICAL CHEMISTRY PULMONARY MEASUREMENTS PAGE 20 20 20 21 22 22 23 23'. 23'. 23 24 24 24 25 35 45 55 65 74 84 85 86 87 98 148 195 245 295 E
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Wdiffirift TABLE OF CONTENT!S~(Continued) APPENDICES (Cant'inued) PAGE APPENDIX 10 - REFERENCES 346. FIGURES FIGURE I - PAOaAN& PACD2 349~ FIGURE 2'- W2 YA5HOUT TO 2% 353' FIGURE 3 - CLOSING VOLUME 357 FIGURE 4 - UIrI,L CAPACITY 361 FIGURE 5 - PN-S-L- III SLOPE 365
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CONFL3!ENTEAL 1. I I t IFOIFIVlIVFUN. IABORATORIES, INC:. SPONSOR: Nat'ionaTCancer Institute Smoking and HealthiProgram. MATERIAL: SEB IV Experimental Cigarettes Codes 111, 113„ 32, and 67 I'NITTAT'ION DATE: November, 1976 TERMINATION DATE: November, 1980 ISSUE DATE: June 15,, 1981 SUBJECT: INHALATION BIOASSAY OF CIGARETTE SMOKE IN DOGS: NICOTINE AND PMO EFFECTS. FINAL REPORT tI t t 1 SUMMARY Under contract No. NO1-CP-55666 with the National Cancer Institute (!NCI), the chronic effects of exposure to nicotine in cigarette smoke were evaluated in ueaglle dogs. The program was initiated at Battelle Northwest Laboratories in 1974 and transferred to Borri'ston Laboratoriies in November of 1'976 where the study was complet'ed in November, of 1981. Four groups, initially consilstiing,of 60 male beagle dogs each, were exposed to modifiled SEB IV experimental cigarette Codes 11, 13, 32, and 67. Codes 13, 111, and 32 varied iin their nicotine content (low, medium, and high, respectivelly) and Code 67 was a high nicotine cigarette with aniaddedianti- ciliastatic agent, 3-phenyl-5-methyl-1, 2, 4,-oxidiazale (PM0). Animals were exposed to the smoke of 12 cigarettes daily through a cuffedlcannula inserted in a tracheal stomai. Smoke was generated by an A'DL-II smoking machine at the rate of 35 m1/2'second puffs every 30 seconds. In addition, 50 male beagles servedlas controls;,4'0 animalls (,sham controls - Code 33) were initiated with Codes 11, 13, and 32, and 10 animals (PM0 sham controls - Code 68) were initiatediwith Code 67. Control! animals were attached to resistance valves. 5050 Beech nlAce • Temple Hi1l., M1Qaryland120039 • 301-899-3"a35
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I I I I , I 1+ I I 1; 1, . k C ~!I~~~~~;~~TIAI Duringlthis study, animals smoked Code 1'3I,, 11, and 32 oigarettes for 1500! days and the Code 6'7'smoked for T100 days., AlT animals were examilned for effects of'chroni'c~smoke exposure after 200, 400, 600, and 10001days of smokingi. The Code 33, 13, 1'1, andi32'dogs were also evaluated after 1200, 1400, and 1500. (terminal) days of smoking:. The Cod'e 67 and 68 d'ogs were tested after 1100 (terminal) days of smoke exposure which inclluded: pullmonary physiology,, herra- tology, hemostasis, andlclinical chemistry. A11 animals were necropsiied and gross inspection was made on all tissue. Microscopic evalluation of these tilssues is in progress at the VA Hospital, East 0'range, New Jersey. Concurrent with the bioassay, the contents of'the cigarettes and'thei'r smoke were monitored. The smoke components receivediby the dog were,monitored also byy determining nicotine and cotinine l~evels in plasma, urine, and, blood carboxy- hemoglobinilevels. Continual smoke exposure for Codes 13 (low),, 11'(imi'd) and 32 (high)' resulted in aidecline in pulmonary functiian when these graups were compared to the control group (Code 33). The following changes in lung function were observedi at the following exposure intervals: ~ an increase in Phase,III slope in all codes at all exposure intervals.. • an increase in N2,washout volume in al'l codes at al'1' but one exposure interval (iCode 13'at 600 days). • a decrease in hemoglobin levels in aTllcodes at aTll exposure intervals. ~ an increase im.carbaxyhemogllobin 1'evells in all codes at all exposure intervals. Decreased pulmonary function in Code 67 (PM0) when compared to its control group (Code 68) was observed at the following exposure intervals: « an increase in Phase I'.II slope at all exposure intervals, • an increase in N2,washout volumes at Days 200 through 800. • an increase in hemoglobin levels at Day 400', followed by decreased levels throughit'ermrination. -2- 3' i
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~~~OE`f~~~ENT1AL I 0 I I II Closing volume, vital capaciity, Pa02, and PaC02 remained essentially the same as the control groups for Codes 13, Tl, 32, and167 at all exposure times. Consistent changes in some of't'he hematolog,ic parameters were observed in all' smokingigroups. These changes were: 0 increased'whnt'e blood cell (WBC) counts in all smoking groups (Code 13, 11, , 32, and 67) after 200 days.of smokiing.. decreasedired bllood cell (RBC)' count and hemoglobin concentrations in all smoking groups starting after, 400 dgys,of smokiing. Hematocrilt values were decreased after 60&days of exposure. No smaking related changes with,regards to hemostasis or cTinrfcalicnemical determinations were noted. Submitted by: i hhccilrio, Ph.D.Stvdy, Director 1
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C~N, s1 LE N, T'r~ I I 4 I I ' I I I ® INTRODUCTION The Smoking and Heal'th Programiwas conceived in 1968 wiith the goal' of developing a less hazardous cigarette. One stepitowards this goal'i is the identification of the hazardous components of cigarettes.. One approach to fullfilling this objective has been the refinement of'the beagle dog as a biioassay model for studyiing the effects of'chronic exposure to nicoti'ne,in cigarettle,smoke. In 1974, BatteUe Northwest Laboratories (BNW)l, under contract to NCI, initiatedia study to evaluate the carcinagenicity and toxicity of cigarette smoke in the beagle dog. Phase I of the study included' establlishing the methodology for longterm exposure of dbgs to machine- ~ generat'ed cigarette smoke, developing techniques to monitor, i'nhaled and retained dose, defi'ning chemicall analysis protocols to monitor smoke, composition, and developing experimental procedures for Phase II of' the bioassay. Phase I was initiated at BNW and was completed May, 1976. Three groups of'60 dogs,each were exposedltolthree experimental cigarettee codes (11„ 13'„ and 32) with varyinginicotine levels. A fourth group of 40 dogs was initiated as sham controls. Within each group the animals were divided into sets of 20 dogs each. Baseline pultnonary physiology andlclinical laboratory studies were performed at BNW. All of the animals reached 100 days exposure at BNW'andialT of the sham control groups andi two of the three sets of dogs i'n each of the treatment groups reached 200 days exposure at BNW. Tiherefore, biomedical measurements and routine sacriificess at these intervals were performed'at BNW.. In November of 1976, the study was transferred t'o:Barristlan Laboratories,, I~nc. under Contract Nb. N01-CP-55665. Phior to reinstating the study, some modificati'ons were,made in the smoke exposure nethodalogy. The BNW smokingi machine was replaced by the AOL II (Arthur O. Little) smoking system siince it has been demonstrated that it is easier to aperate and maintaiini, and is at least as reliable as the BNW'system. A'lso, noncuffed tracheall cannula. were replaced with the cuffed variety. A cuffed tracheal cannula forms a seal' in the trachea insuring that the dog iinhales only the air and smoke from the smoke delivery tube. -4-
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I 1, t I I #I In December of 1976, the:smoking study was re-instated at Borriston and by January of 1977 all of the dogs were smokiingithe requiredlll2'cigarettes per day. These,dogs reached 4'00 days exposure between June and October of 1977 and the data for this period were presented in Borriston's first annual report to NCI covering Nbvember„ 1'976 to November„ 11977. During MBrch and April of 1977, an additional group of 60 animals were placedion study to evaluate the effects of an anticiliastatic agent (PMO)i in a high-nicotiinee ciigarette. Along with these animals,,an additional group of ten sham con- trol' dogs were placed on study. Prior to smoking,,baseline pulmonary physiology, andlclinicali laboratory studies were performedioniall Code 67 and "PMO" sham control' (Code 68)ldogs. These data were presented in the second annual reportt i!ssuedlin November of 1977. _ The study continued at Barriston through 1500 days of smoking for the initial' groups of'dog,s (Codes 13, 11, 32, and 33'"Controls") and through 1100, days of' smoking for the Cbde 67 andi6'&'dogs. The results of this program are. includedlin this report. TEST ANIMALS AND HUSBANDRY I I Two hundred seventy-seven (277')lmale purebred beagle dogs were received from Battell'e Northwest Laboratories (BNW)',, Richl!and, Washington, on November 14 1'976. Forty-one (41) additional male beagle dogs were receivedlfrom Hazleton Research Animals Inc., Cumberland„ Virginila between Nbvember 19 and December 10i, 1'976L A'1'1 animals were observed for appearance and behavior for a mirrimum of' one week priior toisurgery or reinstatiing the smoking regiimen. All animals weree individually housed in suspended cages with Wayne(!~ Bite-Size Dog Food and water, viawater,bowl, freely available. Veterinary,carewas supervisedlby;a Board- certified veterinarian andia record of al'1 treatments and medications was maintained. A'nimals were divided into wards of' no more than 30 dbgs each. ASSIGiJMENT! TO TREATMENT GROUPS The allotment of animalis to groups is presented in Appendix 1. Since the sham controls and Codes 111, 13', and 32 animals were placed on study at B"1'~, the ariginal groupidesignations were maintained. The Code 67 animals and PMO0 sham controls were initiated at Borriston. Withiin each group, the dogs were divided ilnto sets of 20.. -5-
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I I I t I !'. I I i I I I I Code Tl was an SEB I'V cigarette,with niicotine removedland then 0.5: mgi nicotine/cigarette added. Code 1i3'was an SEB IV cigarette wiith mostl of the nicotine removed and assayed,0.1 - 0.2'mg,of nicotine/cigarette. Code 32'was an SEB'IU cigarette with nicotine removediand 2'.0 mg nilcotine/tigarette added. Code 67 was a Code 32 cigarette with PMO, an anticiliastatic mat'erial,, added. SMOKE EXPOSURE TRACHEOSTOMY Tracheostomies were performed an the normal dogs received from BNW,and the dogs acquired from Hazl'eton Research Animals using a modifi~cation of' the pro- cedure describedlby Dr. D~ W. DaTgard,Haz7eton Laboratories America, Inc. An elliptical mridlline skin incision was made on the ventral' surface,of the-neck, approximately 2 cm from the cricoid cartilage. The underlying cutaneous muscle was clipped away, exposingithe sternohyoidbus muscles, which were separated along the midTiine t'o~expose the trachea. An ellipt'ical section of the trachea was dissected out, creating a 2.5.x 0.5 cm orifice which was then enlarged by sectioning;the exposed tracheal rings. The underlying mucosa was separated, and later sutured to the,skin to effect cllosure, using simple interrupted sutures. No bandaging or external applicatiions were emplloyed'. The dogs were examinedd daily to insure proper healing. Liit'tle or no post-operative care was required. TRAINLNG Following tracheostomy, each dog was allowed aiminimum~of two weeks for recovery, during which time each was observed closely for post-surgical complications. After this period, each set of dogs was given daily training sessions toibecome accustomed to standing or sitting in place in the exposure 5talTs witlhi the tracheostomy tubes i'niplace. The dogs were then sham smoked on machines without cigarettes for a few days to become accustomedit'aithe smoking apparatus and the sounds of theg smoking machi'nes. Dogs which had'been on the smokiing regimen at' nNW'were ret,urned to smoking by starting with two cigarettes per day, one in the morning andlone in the afternoon, grad'ua1Ty increasing over a two week perilod to 12 cigarettes per day. Dogs in the Code fi7'group1were also started wilth two cigarettes per day, butt the rate of increase was sllower. The final level of 12 cigarettes a day was achiieved in two andi one-hadlf to six weeks. -6-
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p*a,' _ i-+'r? F ~I^g i The dates alil dogs initiated smokiing,at Borriston and the dates of'100,. 200, 400, 5001, 800, 1000, 11,00, 12001, 1400 and 1500 day,s exposure are presented in Appendix 1. SM014IiNG PROCEDURES All dogs withinieach ward were smoked at the same ti'me. Sham dogs were smoked in subgroups of 10 dogs at a time. Each animal was exposed to the smoke from 12 cigarettes per day, seven days per week. Smoke was generated by an AOL-II smoking machine (Appendix 2) at the rate of 35 mll/2 second puffs every 30 seconds. Smoke iis generated by piston acti'on into the delivery tube (Appendix 3). Freshly generated puffs of'smoke were administered via tracheostoma into the dogl's respiratory system. The dog inhaledlthe 35 ml puff of smoke within five seconds of its generatiion. Prior to re-initiatingismoke exposure in the dogs received from,BNW„ some modifications were made in smoke generation and delivery procedures. These modiifications incliuded replacement of the BNW smoking machine with the ADL-II and substitution of the uncuffed cannula with the cuffed variety. QUALITY CONTROL OF CIGARETTES AND'SMOaE EXPOSURE CIGARETTE MAINTENANCE AND CONDITIONING All cigarettes were maintained at -20°C until required for testing. Code 1'1, 13, and 32"cigarettes were stored in polyethylene wrapped cardboard trays and Code 67 cigarettes were stored in cartons containing ten packets of 20, cigarettes each. Prior toluse, Code 11, 13, and 32 cigarettes were removed from the tray, placed in baskets,, thawed, and'conditibned in a humidiifier for 48 to 72 hours at 241*1°C and 60± 5% relative humidity. Code 67 cigarettess were thawed overnight at room temperature in unopened packets. A sufficient number of cigarettes for each smoking session was delivered to the exposure room imthe morning and'the afternoon. Code 67 cigarette packets were opened in the smoke exposure room just prior to use. CIGARETTE AND SMOKE ANALYSIS Each time a tray of Code 11, 13, or 32'cigarettes was openedl„ 25 cigarettes were randomliy selected for analysis andlwere designatedlas "t'ray sampl'es". Ini addition, teniconditiioned Code 11, 13,andl32 cigarettes and alpacket of Code 67 cigarettes were selected weekly for analysis. The cigarettes were known as "exposure room samples". -7-
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4 I I I I I 4 I I I I kli faiL`i~~.ll IlAIL Accuratle,definition of the smoke dose offered to the,dogs was assured by testing the cigarettes to:provide aistandard for comparing analytical chemistry within;the Smoking andlHealth Program. Reference code 1R11 ciigarettes were also analyzed. Monthly analytical results of "tray sample" and "exposure room sample!"cigarettes are presented in detail in Appendix 4. Included in these analyses were t~he following: • Resistance to Draw - Ciigarettes of'each code were testedifar pressure drop using a Filtrona PDA VP pressure drop tester • Cigarette Weight - Cigarettes sellected from each cigarette code tray were weighed to the nearest milligram. • Totall Particulate Matter - Four "t'ray sample" cigarettes of each code were smoked each week on a four port AmericaniFiltrona Analytical Smoking Machine. The cigarettes were smokedlusi'ngia two second puf'f, 35 mll puff volume, andia one minute puf'f'cycle. The ci'garettes were smoked to a butt length of 23+1 mm. The particulate phase of' smoke was collected on, 44 mrm standard'Cambridge filter pads (Phipps and Bind Corp., Richmond, Va.)i. Filter pads were wei'ghed'to determine,total partiiculate (TPM) and placed iln a vial containing 10 ml of' ethyl acetate. Vials were spiked withiacenaphthene as an internal standard. The nicotine and water collected from the smoke were dissolvedlin ethyl acetate,and each component quantitatiively analyzed by gas chromato- graphy. Five "exposure room" cigarettes of each code,were smokedleach week on the A'DL-IiI smoking machines. The cigarettes were smoked using a two second puff, 35 ml puff volume, and a 30 second puff cycle. The cig- arettes were smoked to a butt length of'23+1 mm.TFie particulate phase of smoke was collected on Cambridge filter pads which were placed at the cannula endiof a smoke transport tube. Smoke was drawn through thee filter by a Model 613 Harvard Animal Respirator (Harvard Apparatus Co., Millis, MA)„ usiing a tidal volume of 1100 ml, a rate of 16 cycles per minute, andla 50-50 expiratory-inspiratory cycle ratio to sinullate a, dbg breathing; from the system.. • Micotine - Ah aliquot of the chloroformlor ethyl acetate extract'ion solution was analyzed onia Perkin-Elmer Model 3920 gas chromatograph (Perkin-E11mer, Norwalk, Conn.), equipped with a 91 cm Sillar 10 C, 10% on 100/120 mesh gas chrom Q,coTumn and a flame ionization detector. The retention time andlarea response of the nicotine peak were determined and quantiified by comparison with known standard solutions of nicotine -8r
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C i1'dli I±1Li11111YS7L i I I I 4 I ! I I t, W prepared from reagent grade nicotine (Eastman Kodak,,Eastman Organic Chemicals Dnvision„ Rochester, New York)'. ~, Water Content of Smoke - Quantificatian of the water cont'errt of smoke was achievedlby analysis of' the materials extracted from the Cambridge filter pad by ethyl acetate. An aliquot of the solution was analyzed onla Carle Model AG 1111 gas chromatograph.(:Carle Tnstlrument. Co., Fullerton,,California), equipped with a 125 cm Porpak QS column and althermal conductivity detector. • Water Content of Cigarettes - Three cigarettes of each code are: analyzed each week to determine water content from cigarettes in exposure rooms. The cigarettes are placed in capped test tubess containing 10 ml of anhydrous methanol and shaken for 30 minutes. Water content of the,methanol extracts are determined on the Carle Mbdel AG 111 gas chromatograph described above, and are included in Appendix 4. * PMOiContent of Code 67 Cigarettes - PMO content was determined in conjunction with nicotine analyses of' the Cambridge filter pad wash solution by gas chromatography using the Silar 10 C column,. Conditions employed gave excellent resolution of niicotine and PMO. Retention time and area response of the PMO peak was determined and quantified by comparison with standard solutions of PMO:suppTied by Dr. Marmor,, LoriilTard' Tobacco, Co., G'reensboro, N.C. Machine Ca1ibratilon - Smoking Machines were checked!and lubricated as necessary each day. At two week intervals, each machine was completely disassembled, iinspectedl,,and the "0" rings replaced.. Before being returnedlto service, the machines were tested for pressures and volumes as prescribed by the manufacturer. One hundhedl twenty five machines per month were tested for smoke delivery by smoking one Code 1R1 cigarette. A Cambridge filter was used to colllect smoke particulates, using the same technique described above for "exposure room" cigarette analysis. Data were collected for delivered TPMIandinicotine. . I PULMONARY PHYSIOLOGY The cardia-pulmanary systems of alll animals were monitored at regularly
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CIgN;~ID~~ITa~L schedu]ed'iintervalls: prior to smoking, after 100 and 2001days of smoking, and every 200 smoking days thereafter. The folllowing measurements were taken, on all' animals; # nitrogen washout to 2% ' r minute volume * tidal volumee r respi ratory rat'e, r vital capacity r alveolar plateau r closing vollume • arterial blood gases • oxyhemoglobin saturation ., hemoglobin Three lead electrocardiograms are performed on alll dogs prior to initial smoking and prior tolsacrifi!ce.. BNW measured pulmonary functions oniall sham control and Code li, 13, . and 32 animalis pre-exposure (baseliine) and after 100 days of exposure. BNW also determrinedl200 day exposure vadlues on a1l! sham controls, Code 11 subgroups X ~ and'X2, Code 13 subgroups V11 and'V2, and Code 32'subgroups WI and W~. The following physiology measurements were performediat BorristonlLaboratories, Inc.:, 400, day exposure values on a11' sliam, controTs andiCode 11, 13, and 32 animadls, baseline values on al'll Code 67 and 68 (sham control) dogs, 600, 300, 1000!,, 1200,,14100, and 1500 day exposure values for alil sham controls and Code 11, 13, and 32 animals,, and 6001, 800,, 11000,, and, 1~1'00 day exposure values on all Code 67 and Code 66' (isham control!) animals. r Nitrogen Washout (N~) - Approximately 30 minutes before testing,, 0.77 mg/kg of Acepromazine M'aleat'e ~' (Ayerst Laboratories, Montreal, Canada)) was administeredlintramuscularly toleach dog. During testing, thee sedated dog was immobilized in an upright posiition. A cuffed tracheostomy tube was inserted into the tracheal stoma and inflated to prevent air from escaping around the trachea. The tracheostomy tube was then connected to a13rway breathing vallve which contained the sampling valve for the nitrogen analyzer. The dog was alilowed to breath room air until respiration stabilized. At the endlof a normal expilration, the breatfiingi valve was turnedl to! 100°l oxygen an6 tai the gas collectiing apparatus. The expired gas was collectedlunti,l a 2°"-' nitrogen level was attained. -T0-
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lrgp~i yyliuIL I I I II t I I 1 1' I I 11 V Expired nitrogen concentration was measurediusing a Hewlett Packard Model 47302 A fast response nitrogeni anallyzer, and the expiired gas volume was collected in a 13.5 liter water seal spirometer (Warren E. Collins, Braintree, Massachusetts),. Volume to12f nigrogen, tidal volurne, respiratory rate, andim'rnute vol'ume were determilned from the spiromet'er tracingl. All volumes were corrected for body temperature pressure saturated (BTPS). • Minute Vol'ume., Tidal' Vollume and Respiratory Ratle - Minute volume,, tidal volume, and respiratory rate were! determined from the spirograiphic tracing obtainedifrom the N2 washout test. Alll volumes were correctedd to BTPS (body temperature, ambient barometric pressure, 38°C, saturated wiith water vapor),. . ~ ` * Single Breath,N2 Test (Vital Capacity,, Alveolar Rlateau„ and C]losiing Volluime) - After the N2 washout test, each dog was allowed aiminimum of 20 minutes to equilibrate to room air. The tracheostomy tube, with cuff deflated, remained'in place during this time. Each dog, after receiving Acepromazine© approximately one hour before, was then anesthetized with sodiium pentobarbitall (26.4 mg/kg). The anesthetic was slowly administered ilntravenously until the desired level of anesthesia was attained. The dog was then placedlinia supine position at an angle of 30° with the head at the highest level. An esophageaT balloon was inserted into the esophagus and placed approximatelly iin the middle third portion to determine.pleurall pressure. The balloon, containing T.01cc of air,, was connected via 60 cm of' PE-240 tubing to a dhfferential' pressure transducer. Pressure calibrations were performed using a water manometer. Transpulmonary pressure (~Ptp) was recorded as the difference between the esophageal balloon pressure and the pressure at the opening of the~tracheostomy tube. Volume was derived from the electronic integration of the flow signal obtained from a Fleish No. li pneumotacho- graph, and percent N2 was measured with a rapiid response N2 analyzer. Nitrogen concentration versus volume was disp7ayed on an X-Y plotter. Tihe:maneuNer was performed by twi'ce inflating the dog's lungs with breathing quality air to +30cm H20 transpulmonary pressure (?tp) to, -11-
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4 a 4 -4 4 E °'1 1 I I I I . I q 9 .1 establish a constant volume history, followed by a passive exhadlation!. Thils maneuver adlso rendered the dog apneic. The lungs were deflatedd to -10 cm HZp Ptp (residual volum:e) followed'by an infl'ation with 100% 02 to +30cm:H20 Ptp (tot'al lung capacity). The lung was again deflated to residuall volume while recording N2 concentration versus volume on the X-Y plotter. A final~ . inflation of the l!ungs to near total lung capacity were performed in order to prevent possible respi'~ratory effects which could result from the deflation to residual volume.. Inflation and deflation rates were 76,m1/sec. Vital capacity, alveolar plateau (slope of Phase IUI), and clio5ing,volume (Phase IV) were calculated from thi's pllot. Arterial Blood Gases - Immediiately fdlllowi'ng,administration of'sodhum pentobarbital for the single breath N2 test, arteriall blood was colTec,ted anaerobically from the femoral artery using a heparinized glass syringe. Blood was analyzed immediately ini order to minrimrize any changes in the blood gases whiicfi occur when the bllood stands at room temperature. An Instrumentation Laboratory Blood Gas A'naTyzer (Model 213)iat 38°C was used to determine the pH and partiali pressures of oxygen (Pa02) and carbon dioxide (PaC02)1. The blood gas analiyzer was calibrated twice dailly. Oxyhemoglobin saturation(HbO2)', was determined from the arterial blood sample with an Instrumentation Laboratory Model 182 Qo-Oximeter. Hemoglobin content was measured with a Coulter Hemoglobinometer and the Model 182 Co-Oximeter which had been calibrated wilthinormal dog blood.. CLIiNICAL LABORATORY STUQIES Blood samples for hematology', hemostasis, andiclinical chemistry profiles were colliected from all animals at scheduled intervals.. BaseTine and 100 day exposure values on the sham controlis and all Code 11, 13',,and 32 animals, and 200 day exposure values on all sham controls,,Code 11 subgroups X1 and X2, Code 13 subgroups V1 and'V2, and Code 32'subgroups l•ll and WZ were determinedl at BNW. Clinicali laboratory studies of Code 11 sudaroup X3, Code 13 -12-
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C 0 1~~Firotul T1:i1' 4 W I 4 0 I I I I I I I subgroup V3, and! Code 32 subgroup W3, at 200 days, Codes lil „ 13', and 32 at. 400 days and Code 67 and PMO sham cont,rol' baseline studies were performed at Borriston. Blood profiles were also determined on all Code 111,13, and 32 and sham control animals following 600, 800,,1000,,1'2001, 1400, and 1500 days of exposure,, and the Code 67 and PMO sham conta'rol animals following 400, 600,,800, 1000,, and'. 1'1'00idays of'exposure. Dogs schedulled for sacrifice at these intervals weree sampled prior to euthanasia. References for clinical laboratory procedures are presented iniAppendi'x 10. HEMATOLOGY Blood for hemat'ology studies was colllected fromi thejugular vein into 5 ml evacuated tubes containing tripotassium EDTA'as the anticoagulant. Hematology parameters evaluated'were erythrocyte count, total' and di'fferentiad! 1'eukocyte counts, platelet count, hemog1obin level,,hematocrit, mean corpuscular volume (MCV)', mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin con- centration (MCHC). Erythrocyte and leukocyt'e counts, hematocrit, MCV, as well as hemoglobin concentrations were det'erminedlusing a Coulter Counter Model ZF-5 (Coulter Electronics, Inc., Hialeah„ Florida),. Platelet counts were performed on a Technicon Autocounter module of a Techniconi Autoanalyzer I'I ('Technicon Instruments Corporation„ Tarrytown, PV.Y.)., The erythrocyte indices (MCH and MC:HC), were calculated. For differential leukocyte counts, 100 leukocytes stained with Wright-Giesmaistain were classified. HEMOSTASIS The criterion for eval'uating hemastasis was platelet adhesiveness. Bllood samples were coillectediprior to, smoking and fifteen minutes after smoking the first cigarette of the day. Blood for platelet adhesiveness testing was collected from the jugular vein into a plastic syringe using a 19 gauge butterfly infusilon set and then forced to flow thraugh a glass beadldeviice at a constant rate of 3.5 ml/minute. The first 2 mi of blood was discarded and the third and fourth ml were each colllected into a tube containing tripotassium EaTA. Platelet counts were performed on each of these samples and compared to the counts obtlained on native whole bloodlt'oideterniine the percent of platelet adhesiveness. Platellet aggregation studies were performed by the method described by Born usiingia platelet aggregometer. The change in light transmittance following the -113,
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i ~i~~ l:~r^rI~ilDe~ ~~ay ~ltla, .1' . -1 I ! I If addition of exogenous triggering~agent's (adenosine diphosphate (ADP) and collagen) was measured. Blood was collected from the jugular vein into a syringe containing sodium citrate as the anticoagul!ant. PTatleJet-rich plasma (PRP) was obtained by centrifuging the blood at 500g for ten minutes at 23°C. The PRP'was recentrifuged at 1800 x g for 30 minutes to obtain platelet-poor plasma (PPP')I. The samples were transferred with pllastic~pipets to plastic tubes, covered, allowed to stand for one hour at room temperat~ure and then analyzed. The ADP and collagen were prepared according,to the manufac- turer's specifications (Bio/Data Corporation,Horsham, PennsyTvania) in order to obtain concentrations in the test system of 2 x 10-5M and 0.26'mg/ml, respectively. CLINICAL CHEMISTRI' ~ Blood flor clinical chemistry determinations was collected from the jugular vein prior to the animall smokimg the first cigarette of' the day. Ten milliliter serumiseparation tubes without anticoagulant were usedifor blood collection to assure fibrin-free serum samples. The blood was allowed to clot for thiirtyy minutes and centrifuged at 1800 x g for li2'minutes. Aliquots of the serum were quick-frozen at -40°C for subsequent clinical' chemistry testingi. Serum protein elsctrophoresiis was performed by the zip-zone cellulose acetate method on fresh serum samples within 24 hours of collection. The folllowi'nglclinical chemistry parameters were determiined on thawed serum sanpfiess using the Technicon Autoanalyzer II;, albumin, bloodi urea nitrogen, cholesterol',. calcium, creatinine, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic t,ransaminase, inorganic phosphorus,,and total proteini. QUALITY CONTROL The accuracy of clinical laboratory values was assured by the routine calibration of'instruments using commercial standards. Normal andlabnormal levelis of the Coulter 4C Cell Controll were documented daily on the Coulter Counter Model ZF-5. The Coullter Hemoglobinometer was calibrated monthly usingithe hemo- globin standard Hb10 and Hb20. The TechnicaT Autocounter platelet analyzer was standardized prior to each use using the Technical Normal Calibrator. The sensitivity reading from the Autocounter was taken at the beginning of each run -14'- ~.-___
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and chartered on alstandardiLevx-Jennings chart. The Platelet Calibrator was assayed by the laboratory upon receipt and verified every three months thereafter until the lot expired:. The assay was performed by counting blood specimens onithe phase microscope, calibrating the Autocounter to the counted values and then processing,numerous randomly selected samples of'the calibrator material through the Autocounter. The average of the calibrator results was used as the assay value during subsequent runs. CliniicaJl chemistry tests on the Technicon A'utoanalyzer II were monitored through the use of SMA Reference Serum 2'as a standard and Monitrol I and II as contlroll. The standard and blank were run at the beginning of the day and after every'20 samplles_ The control's were run at the beg,inning of the day and after interrupti'ons in the testing process, Serum electrophoresis was moniltored'before,and after every six samples using the Dade electrophoresis control (,Dade Division, American Hospitall Supply Corporation, Miami,,Florida). The percent of total integrations for each protein fraction as well as totall integrations were recordhd on Levy-Jennings charts. TERMINAL STUDIES SCHEDULED SACRIFICES Initially, schedulied sacrifices were performed on dogs fhomieach of Codes ll, 13, 32, and 33 at 200 day intervalis. Scheduled satrifices on all codes were suspended'as of September„ 197& due to high mortality in some groups. NECROPSY Dogs scheduled for sacrifice were euthanized with an intravenous injection of T-61'(National Laboratories Corporation, Subsidiary of American Hoechst Corporation, Somerville, New Jersey) and exsanguinated. A complete necropsy was performed on each animal at the time of sacrifice or death by a modified Rokitansky technique. Special care was given to organs of the respiratory and cardiovascular systems. The larnyx,trachea, and 1lungs were removedier. cZo0 and examined visuallly and by palpation. The trachea was separated just distal to the tracheostomy stoma, and the proximal portion opened Tongitudinal1ly, and inspected'for gross lesions. The cranial section of trachea was then fixed in 110% neutrall buffered formalin so7ution. -1'5-
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~~~ C ~, .~~,.~~,~~ ~~ a~~.T s~~ The distal trachea and lungs were fiked by intratracheal, perfusion of 101" neutral buffered formalin at approximately 25 cmiof water pressure while suspended in formalin solution overnight. Following fixation, total lung volume was determiined by volume displacement. Following separation from the lungs, the heart was examined for gross lesions and the coronary arteries were removed and fiixed in 10% neutral buffered formalin. The following organs and tissues were removed from each dogi„ examined, and fixed in 1'0% neutral buffered formal'in:: skin sample spleen eyes l i'ver salivary glands gallbladder sternal bone marrow, kidneys rib:junction adrenals " ` peribronchial lymph nodes urinary bladder esophagus prostate thyroidl testes stomach femoral vein duodenum braini jejunum spinal cord'' ileum pituitary cecum aorta large,intestilne diaphragm pancreas At the time of necropsy any gross pathological alterations were recorded. PATHOLOGY, AND MORPHOMETRY Alll tissues saved at necropsy were fiorwarded t'o~Dr. Auerbacn, V.A'. Hospital, East Orange,N.a'. Dr. Auerbach was responsiblle for blocking!the lungs, preparing staimed sections of'the tissues, and examining the tissues for detailed gross and mncroscopi'c pathology. The following procedures were to be followed by Dr. Auerbach's group in the histopathological evalluation: Trachea~- T!he tracheobronchiall tree is examined for changes in the epithelliurm bronchial walls, andlmucus g,lands. Twolcross-secticns per tracheal ring of 5 microns each are dehydrated in a graded series of allcohol, clearedlin xylene,, embedded in Paraplastc ", sectioned, and st'ained with hematoxylin andleosiln (HF;E) and Periodic-AcidlSchiiff (PA'S). The H8E stained sectiions are examined for evidence of epithellial hyperplasiai, metaplasia, and neop7asia. The PAS-stained sections are examined for evidence of increased mucus secretion. -16-
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I I I . I t I I l, li I 'I L The degree of'atyprism is recorded for bronchii and trachea:. Important changes in degree of basal cell hyperplasia and squamous metaplasia are recorded. The number of goblet cells per nuclei is determined fromleach of upper, midportion, and lower trachea,,and each.lobar bronchus. The proportion of mucous glands in the tracheal' and bronchilal' walls„ and the relative size, are estimated by a point oounting method and~determination of' the Reid I'ndex, respectively. Lun - The fixedlvolume of lung is determined by water immersion. Each lobe of the lunglis cut into 1 cm slices. Three sections (lx2 cm) are taken from the apical, vasal, and midportion each of one lateral slice, one medial sl'ice„ andl one mediastinal slice. Each section is dehydrated in a graded'series,of alcohol', cleared in-xylene, embedded in ParapTast~', sectioned atl 5 microns, and stained with hematoxylin and eosin (H&E), PAS„ and Verhoff-Van Gieson stain for elasticc fibers and colilagen. Observations are made for fibrotic changes in the walls of alveolar septa as we1i1 as rupture and tearing of'the alveolar septa,. Bronchial Epithelium - Epithelial hyperplasia in the bronchial mucosa is quantitated by recording the number of rows of' basal cells and degree of atypism in 1'0 widely separated cross-sections from three different bronchi in each of two lobes.. Twenty longitudinal sections of terminali and'respiratory bronchioles are examined for epithelial hyperplasia, metapdasia,neop1asia,,and size of mucous glands. The parenChymalof'the lungiare examined:for enlarged alveoli andlother evidence of'emphysema. PulMonary Vascu]ature - The pulmonary arterioles and arteries are examined using the Verhof'f-Van Gieson stained sections. Changes in hyaTiine thickening of arterioles and intimal thickening of arteries are noted with the degree of atypism. Ten measurements of inedial, thickness of the transverse sections of the pulmonary trunk and aorta are made with a calibrated eye piece.. The meam medial thickness of'the pullmonary trunk (PT) iis expressed as a ratio of the meani medial thickness of't'he aorta (A)' -(PT/F ratio). -1 7-
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CGINFULji ~11lA 1 11, 11 14 4 4 `1 I q I I I The external diameter of at least five c,ircuiar arteries in each section, expressed as the mean of' two measurements taken at right angles to each other, of the distance between diametrically opposedipoints in the external el'astiic l'amina is made. The medial thickness is estimated from t~he mean,of four measure- ments taken at approximately equally spaced points around the vessel wall. The thickness of the media is expressed as alpercent'age of the external diameter. SystematiicVasculature - Hematoxyllin and eosin and Verhoff-Van Gileson stained secti'ons of the small arteries and arterioles in the gastrointesti'nal tract, pancreas, and adrenals are prepared. Two sections from each adrenal are pre- pared. The thickness of the arterial and arteriole walls is estimated similarly to the method described above for the pulmonary arteries and arterioles. Aorta - The formalin-fixedlthoraciic and!abdominal aorta are grossl~ stained and evaluated using the methodlof Holman, McGiill, et aZ. This method employes Sudan IV which st'ains the fatty streaks andideTineates any fibrous plaques. The severity of these two gross lesions is scored andithe stained'aorta is storedd in plastic bags. Remaining Organs - Because of the uncertainty of the clinicall siigns and thes results of the cliinical and physiological measurements, the remaining,organs flixedlat necropsy are held for possible hilstologicall eval'uati'on,. Sections are preparediand microscopic evaluations are made of the remaininglorgan systems as indicated!by the results of the various observatiions during the course of the study. -18-
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a 14 iq RESULTS ~ T '~ ~ IW; 'J~J~ I CC ~SYb HEMATOLOGY' Individual hematology data:are presented in Appendix 5 and mean values are presented, in Tablle 1'. Mean values marked with S+ or S- are statiistically significantly higher (S+) or llower (S-)' than, the respective control value as measured by Student'''s t-test at P<0.05. Hematology'data on Codes 13, 11, 32, and 33'at Days 0 and 100 andlon Code 33'at Day 200 were not collected at:Barriston, and are therefore not included in thiis report. All testing not performed at this laboratory was conducted at BNWiprior to transfer of' the dogs to Borristan. RBC, Hematocrit; and EemcgZobin - Statistically significant decreases in RBC counts, hematocriits, and hemoglobin values were noted in Codes 13 (low)i„ 11, (midQ,, and 32 (hiigh);as compared toiCade 33 at the 600„ 800, 1000, 1200, 1'400,,and 1500 day intervals (except for Code 11 hematocrit at 1000 days). These findings are considered to be related to chronic smoke exposure. Iin addition, statistically significant lower hemoglobin val!ues and RBC counts in these three codes at 400 days suggest an early response to the smoking regimen. RBC, hematocriit, and hemogllobiin values for Code 67 (PMO) were g,enerallly lower than Code 68 (PMO control) values from Day 0 through 600 days of exposure. The statistical significance of these lower values was sporadic and is not considered treatment related through 1000 days. These erythrocyte parameters were statistically significantly lower than Code 68 controls after 1100 days of exposure. These findings were similar to the other smokingi groups and suggests that the smoke effect for Code 67 dogs may have been delayed because of the RMO1in these cigarettes. WBC - White bllood cell counts for Codes 13, 1'll, and 32' at the 400, 600, 800 1000, 1200, 1400 and 1500 day intervals and Code 6Z at the 100, 200, 400, 600i, 1000,and11,100 day intervalis were statistically significantly higher than, those of the respective control groups. The magnitude of't'he elevated WBC counts were simillar for Codes 13, 111, and 32:, while increases in WBC's for Code 67 were not as large as those for the other three codes. Statisticall evaluation ofi the WBC differential data showedlnaitreatnent-related changes. Sporadic differences from control were noted. -19-
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4ONfIBENTlAL 11 It 4 4 4 I I I 1 I I PLATELETS The f'ollowing statistical'.ly significant changes in platelet count weree observed: r Higher than control for Codes 13, lll, and 32 at 600 and T000 days. M Higher than control for Codes l'1 and 13 at 400'days. I Higher than control for Code 11 at 800 days. t Lower than control for Code 32 at 1200 days. . Lower than control for Code 11 at 1400 days., • Higher than control for Codes 13 and 32 at 1500 days. No treatment-rellated pattern can be ascertained. Platelet counts for Code 67 (1PMO) were statistical'lIy signifilcantlly eTevatedl on Day 400 and statistical'ly significantly lower than control at Day 1000 but were similar toicontrol levels at the other intervals. Platellet results from all treatment groups in this study are within the normall range for beaglle dogs. HEMOSTASI,S Individual hemostasis data are presented in.Appendix 6 and mean values are presented in Table 2'. Coagulation data on Codes 13, 11, 32, and 33 at Days 0 and'1'00 and an Code 33' at Day 200 were not collected at Borriston, andiare therefore not iincludad in this report. All testing not performed at this llaboratory was conducted at BNW prior to transfer of the dogs to Borriston. PZateZet Adhesiveness - No difference in the pre- and post-smoking results were noted between Codes 11 (low), 111 (mid), 32'('high)i, and 33 (controll) at any of the clinical intervals. Additiionalily, no dilfferences were noted between pre- and post-smoking levells for Codes 6'7'(PMO) or 68 (PMO control) and no evidence of a treatment-related finding was notedl. It should be noted that the platelet adhesiveness test is a qualitative platelet function study and'that wide fluctuations in the normal range have been noted by many laboratories performing this test. These fluctuations can be noted in this deta when comparing intervaT to:interval. -20-
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U ~~FID4.NITyl PZatelet Aacrecctuon - Results from Codes 13, ill, 32, and 33 at 200, 400, 600,. 800, 1000, 1200, 14D&, and 1500 days and'from Codes 67 and 68 at 100, 200, 400, 600, 800, 1000,, and 1100 days showed no differences between pre- and post- smoking vallues in either ADP or collagen data. Platelet aggregation is a qualitative platelet function study and, therefore, wide variations in the results have been noted. Platelets are extremely sensitive to experimental conditions which contributes to the lack,of standardization and reproduciibil'ity of' this test. Due to differences between the reaction mechanisms of adenosine diphosphate (ADP) andlcodllagen, the non-surface dependent ADP reaction would be expected to be more reproducible. This is observable in the data by the i'ncreased incidences of negative responses to the collagen stimul'i. - Collagen is a surface-dependent reaction. In orderv for a surface- dependent reaction to take place, certain criteria must be met. The first criterion is a change in shape of the platelets which occurs when an aggregating stimulus is introduced into the platelet' suspension. Fol'liowiing the shape change, an adhesion reaction must take place with pllate1ets adhering to foreign surfaces such as collagen fibers. Once adhesion is initiated, platelet aggregation begins. Aggregation is the property of pTatelets adhering;to each other. During aggregatiioni, platellets release sub- stances such as ADP into the surrounding medrium producing the second phase of aggregation;; the total effect being cumulative. The release of'ADP causes a secondary wave of aggregation which, in turn, causes further ADP'release. In some cases,,the secondary wave of aggregation is not discernible, with the aggregation response appearing as a continuous reaction from introduction of ai stimul'us to total aggregation.. In vitro, using dbg, pl'atelets, the colllagen concentration must be sufficiently high to provide the required surface area to which the platelets may adhere. The data through 1000'days exposure for Codes 13, 11, 32'and the control group indicate that an increased concentration of colllagen is required to decrease the incidence off negative responses. -21-
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CuQFolz;ITlA1 W I . I I 1i I I Due to extraneous variables such as stress-induced plasma catechoTamines and finee fatty acids on aggregatilon, an increased concentration of collagen may not decrease the number of negative responses. SERUM PROTEIN ELECTROPHORESIS Individual electrophoretic data are presented'in Appendix 7 and mean values are presented in Table 3. Mean values marked with an S+ or S- are statistically significantly higher (S+) or lower (S-) than the respective control valiue as measvred'by St'udent's t-test at P< 0,05.. Electrophoretic data on Codes 13, 11, 32, and 33 at Days 0 and 100 and on Code 33'at Day 200 were.not collected at Borriston, and are therefore not i'n- clluded in this report. All t'esting, not performed at this laboratory was conducted at BNW prior to transfer of't'he dogs ta~Borriston. Several statistical'ly significant differences iin various electrophoretlic values were noted between smoking groups andicontroll groups; however, these findings are considered sporadic ininature and not considered to be treatment- related. CLINICAL CHEMISTRY Individual clinical chemistry data are presentedlin Appendiix 8 and mean values are presented in Table 4'. Mean vallues marked with an S+ or S- are statistically si'gnificantly higher (S+) or lower (S-) tlhan the respective controllvalue as measuredlby Student's t-test at P'<0.05. Clinical chemistry data on Codes 13, 111,32, and 33 at Day 0 and 100, andlon Code 33 at Day 200 were not collected at' Borriston, and are therefore not imcluded in this report. All testing not performed at this laboratory was conducted at BNWiprior to transfer of the dogs to Bbrriston.. Sporadic incidences of statistically significant differences between smoking groups and controls were noted iin the eval!uation of the clinical, chemistry data. However, no evidence of a treatmerit-relatedieffect is apparent. -22- JI
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ccNlj"r1) Ec+aT IAi PULMONARY FUNCTION Individual pullmonary function data are presented in Appendix 9 and mean values are presented in Pabl'e 5. Graphic representation of PaOZ and PaCOZ is presented in Figure 1, N2 washout to 2. in Figure 2, closing volume in Figure 3', vital capacity in Figure 4,and Phase I'II slope iin Figure 5. Mean values marked with an S+ or S- are statistically significantly higher (S+) or lower (S,) thanithe respective control value as measured by Student's t'-test' at P< 0. 05. Pulmonary data on Codes 13, „ I1, 32, and 33 at Days 0 and 100 and on Code 33' at Day 200 were not collected at Borriston, and are therefore not included in this report. A1li testing not performed at this laboratory was conducted at BNW prior to: transfer of the dogs to Borriston. P;-iase IIr SZore - The Phase III slope for Codes 13, 11, and 32 were stlatistiicallyy significantly higher than control values on Days 400, 800,, and'1000 and for Code 11 only at 1400 and T500idays exposure (no significance was noted at 1200 days, although Code ll was 15% higher than the control group va I ue )~. Phase LII slope was also statistically significantly higher than controli for Code 67'at 100, 200, 400, 600, 1000, and 11100 days exposure (no significance was noted at 800 days: P = 0.06). Based on the above, treatment-related differences were apparent in the ventilation distribution between smoking and non-smoking groups. However,, no apparent difference,in the Phase III slope was noted between smoking groups with differing levels of nicotine or PMO present. CZoszng uoZur.,e - Closing volume for Codes 13, 11, and 32'did notl differ significantly from control values at any testing interval (400,days through 1500,days). Code 67 didinot differ significantly from control values at any measurement time except Day 200 ('stat'isticaTly significantly lower than contro1). Nz w, s::out - Codes 13, 111, 32', and 67 showed larger N2 washout vollumes than their respective control groups at all exposure ti'mes except for Code 13 at -23-
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C 0 :;1 F1~~E eI TIAL a -4 M 11 tj 60&days (control larger thaniCode 13 group) andiCode 67 at T001days (control i'arger than Code 67 group). The above larger or increased NZ,washoutl volumess were,statisticall'y significant at the folilowing exposure times: r Code 13 (1ow): Days 400, 300, 10K„ 1200', 1400 si Code 11 ('mid): Days 400, 800,,10001, 1200, 1400 . Code 32 (high): Days 400,,800, 1200, 1400 o Code 67 (PM0): Days 400, 600, 1000 As seen with the Phase III slope results, treatment-related differences were apparent in the ventilationidistribution between smoking and non-smoking groups; no difference was noted among srmokiing,groupsg uitaC C=aLi*tu - Vital capacities remainediessentiaTl'y unchangedian all codes for all exposure intervaTs„ and no significant differences between codes weree noted. Since vital capacity generally does not change markedly until a more chronic smoking,condition is obtainedi, one would not expect to see a significant difference at the tested exposure times.. PaO~ nd fc^CZ - Codes 32'and 11' showed statistically signifiicantly lower Pa02 at 1400 andil'500 days exposure. A' significant increase in PaDZ was seen at 1000 and 1l 0&days exposure for Codes 32 and 67, respectively. As can be, seen in the graphs of' Pa02,for all' smoldiing groups,, the plotted values were generalTy consistent with those of the non-smoking groups. Stati'sticaTTy significantly higher PaC02 levels were observed for Codes 13, 11, and'32 at Day 400 compared to Code 33, and a significantly Tower PaCOZ level for Code 11 (mid) was observed on 600 and 1500 days and Code 67 at 800 days exposure. The very high Pa02,leveTs and low PaC02 levels for Codes 67 and 68 on Day 0 are considered to be a result of hyperventilation during blood sampl'ing. The arteriiaT blood sampling procedure was changedlafter Day 0 testing,, and the values returneditoinormal in subsequent tests. RAW DATA'AND FI'NAL REPCRT STORAGE All raw data and the final report will' be housed indefiniitely in thee archives of 8brriston Laboratories, Inc. 5050 Beech Place, Temple Hillis, M'ary1and 200311.. -24-
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i TABLE 1 SUMMARY OF HEMATOLOGY DATA AT 0 DAYS EXPOSURE WDC RBC IIGB HCT MCV MCH SEG. BAND MCHC NEUTRO NEUTRO LYMPH -- - ATY. LYMPH ~ MONO EOS BASO NRBC PLATELETS GROUP (X10lMM)(X10/MM) (G/DL) (%) (U) (UUG) (%) (G/DL) (%) (%) (%) (%) (%) (%) (%) (X10/MM) CODE 33 DATA NOT COLLECTED AT BORRISTON .. .a ea ea .. .. (COIITROL) CODE 13 +. .: " DATA NOT COLLECTED AT BORRISTON (LOU) COUE 11 aa aa aa a• DATA NOT COLLECTED AT BORRISTON .+ (i11U) CODE 32 a+ aa +a ee re " DATA NOT COLLECTED AT BORRISTON .. (H1GII) CODE 68 MEAN 11.89 7.13 16.89 50.36 69.6 23.87 33.81 58.7 0.2 32.3 0.0 7.2 1.8 0.0 0.0 256.7 (PHU CONTRUL) SU 2.74 0.32 0.73 2.69 2.0 0.66 0.79 6.9 0.4 7.2 0.0 1.2 1.6 0.0 0.0 14.6 N 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 ~ 6 CODE 67 MEAN 10.02 6.65°- 15.520- 46.38°-69.0 23.33 33.45 62.2 0.1 28.9 0.0 6.9 2.0 0.0 0.0 281.8" -(PF10) SD - 2.13 0.50 1.24 3.42 _2:5 -0:99 1.00 10.1 0.2 9.2 0.0 2.8 2.0 0.0 0.0 81.4 N 59 59 59 59 59 59 59 54 - 54 54 54 54 54 - 54 54 59 s• statistically significantly higher (e+) or lower (a-) than control value as measured by a student's t-test at ps0.05 4
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M A M WBC RBC GROUP (X1Q/MM)(%10/MM) ** ** CODE 33 (GOpTROL) CODE 13 ** (Lou) COUE 11 (MID) COOL 3[ (iif6ii) SU_MMARY OF HEMATOLOGY DATA AT 100 DAYS EXPOSURE SEG. BAND ATY. HGB HCT MCV MLH MCIIC NEUTRO NEUTRO LYMPH LYMPH MONO EOS BASO NRBC PLATELETS (G/DL) (X) (U) (UUG) (G/UL) (X) (%) (X) (X) (X)- (X) (x) (1) (X1U/MM) DATA NOT COLLECTED AT BORRISTON ** DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON .* ** ** ** +.* ** N ~ CODE 66 MEAN 9.50 7.05 16.85 47.58 66.2 23.92 35.40 67.2 0.0 27.3 0.0 3.3 2.2 0.0 0.0 360.0 (P1-10 COqTRUL) SO 1.26 0.34 0.79 1.46 4.1 0.71 1.02 11.3 0.0 9.3 0.0 2.0 2.5 0.0 0.0 47.9 N 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 CODE 67 MEAN 12.91g+ 6.97 16.41 45.808 66.4 23.53 35.80 67.9 0.1 25.0 0.0 4.8 2.4 0.0 0.0 358.3 (i'(40) Sq 2.18 0.64 1.51 4.01 2.5 0.78 1.08 9.5 0.3 8.6 0.0 3.1 2.1 0.0 0.0 60.4 N 54 54 54 54 54 54 54 54 54 54 , 54 54 54 54 54 54 s= statistically significantly higher (st) or lower (a-) than control value as measured by a student's t-test at p<0.0S P"+'1 ~ i„'~
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- - ""."'[^.., 7r} .. rMF , l .::.r u u u L--i Lr+r TABLE 1 CON'T _5U_M1AR_Y OF kIEMATOLOGY DATA AT -200DAYS EXPOSURE GRuUP WBC RBC (%]0/IM1)(%10/MM) HGB (G/OL) HCT (X) MCV (ll) SEG. BAND MCH MCHC NEUTRO NEUTRO LYMPH (000) (G/DL) (%)(X) (X) ATY. LYMRH (X) MONO (X) EOS (X) BASO (x) NRBC PLATELETS (Y)(XIO/MM) COGE 33 .. a+ .• DATA NOT COLLECTED AT BORRISTON (C011TROL) CUDE 13 MEAN 16.75 6.41 14.99 44.38 68.8 23.37 33.76 67.2 0.0 25.3 0.0 5.4 1.9 0.0 0.1 375.6 (LQII) So 3.09 0.41 1:07 2.84 1.3 0.52 0.84 -7.I 0.0 7.6 0.0 2.4 1.3 0.0 0.3 73.7 N 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 COUE 11 MEAN 18.23 6.49 15.36 45.43 69.4 23.66 33.82 68.5 0.1 23 7 0.0 5 7 0 2 0 0 0 0 387 5 (ialu) So 3.47 0.48 1.25 3.41 1.8 0.88 1.03 6.2 0.3 . 6.2 0.0 . 2.2 . 1.6 . 0.0 . 0.0 . 70.4 N 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 COOL 3e MEAN 15.30 6.50 15.01 45.61 69.6 23.11 32.97 67.5 0.1 24.3 0.0 6.2 2.1 0.0 0.0 324.1 (H1011) So 2.85 0.35 0.91 3.05 3.2 0.69 1.04 7.4 0.3 7.3 0.0 3.1 1.4 0.0 0.0 79.4 N 17 17 17 17 17 17 17 12 12 12 12 12 12 12 12 17 N V COOL Lcf MEAN 10.21 6.93 17.33 47.60 68.6 25.01 36.46 61.6 5.9 26.9 0.3 4.0 1.5 0.0 0.4 438.0 (Pllu CuliTltut ) -- SI) 1.71 0.46 1.34 3.24 2.2 0.80 0.97 8.5 5.3 10.1 0.9 3 4 3 1 0 0 0.5 56 5 N 10 10 10 10 10 10 10 10 10 10 10 . 10 . 10 . 10 10 . 10 COOE 67 MEAN 12.91" 6.79 16.06"- 45.79 67.5 23.66®- 35.070- 67.6 3.2 23.2 0.3 3.8 1.8 0.0 0.1 2 76.4H- (1'NU) SD 2.72 0.55 1.40 3.62 -- 2.2 0.82 0.75 7.5 4.9 7.5 0.7 2.1 1.7 0.3 0.4 _ 84.5 N 53 53 53 53 53 53 53 53 53 53 53 53 53 53 53 53 o = statistically significantl higher (si) or lower (a-) than control value as measured by a student's t-test at p<0.05 6 =7= z9szOV()R
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a...J M i/ M A A A TABLE I CON'T SUMMARY OF HEMATOLOGY DATA AT 400 DAYS EXPOSURE WBC RBC HGB HCT MCV MCII MCHC SEG. NEUTRO BAND NEUTRO LYMPH ATY. LYMPH MONO E0S BASO NRBC PLATELETS GRuUP (X10111M)(X10/MM) (G/DL) (X) (P) (uuG) (G/DL) (x) (z) (x) -(z) M (z) (x) (x) (X1o/Mr1) CODE 33 MEAN 10.76 6.86 16.65 47.46 68.6 24.29 35.23 61.8 0.2 30.8 0.0 4.4 2.8 0.0 0.0 261 4 (CONTROL) SU 2.76 0.59 1.28 4.52 4.9 0.93 2.60 12.0 0.4 11.1 0.0 1.8 2.2 0.0 0.0 . 98 1 N 27 27 27 27 27 27 27 26 26 26 26 26 26 26 26 . 27 CODE 13 - MEAN 17.05g+ 6.548- 16.00e- 46.49 69.7 24.46 34.51 66 7 0 1 27 0 0 0 4 0 2 2 0 0 0 0 n+ 42 (LOl!) - SO 3.15 0.51 -1.25 4.12 3.9 0.70 2_.37 . 7.8 . 0.3 . 7.6 . 0.0 . 2.0 . 2.0 . 0.0 . 0 2 8 3 81.3 N 44 44 44 44 44 44 44 44 44 44 44 44 44 44 . 44 44 COUE 11 MEAN 18.19H+ 6.56° 15.68a 46.09 69.4 23.92 34.21 68.8a+ 0 3 25 3e 0 0 4 0 1 7H 0 0 0 0 s+ (MIU) 51) 4.55 0.48 1.04 4.40 3.8 0.96 2.74 8.5 . 0.8 . 7.3 . 0.0 . 2.2 . 1.5 . 0.0 . 0 0 336.0 89 0 N 46 46 46 46 46 46 46 46 46 46 46 46 46 46 . 46 . 46 CODE 32 MEAN 16.08" 6.458- 1_5.638- 45.40 70.0 24.25 34.52 69.08+ 0.1 24.68- 0.0 4.3 2.0 0 0 0 0 294 4 (F1GI1) SU_ 4.42 0.46 1.23 3.72 4.4 0.84 2.68 10.2 0.3 9.2 0.0 2.4 1.9 . 0.0 . 0 0 . 70.9 N 44 44 44 44 44 44 44 44 44 44 44 44 44 44 . 44 44 CODE 68 MEAN 10.55 7.04 16.67 46.25 65.5 23.66 36.04 67.7 1.7 28.4 0.2 1.2 0.8 0 0 0 0 342 5 (PIiUC0pT80_L_) 50 1.89 0.32 0.61 1.96 1.5 0.73 0.96 8.3 1.2 8.8 0.4 1.5 0.9 . 0 0 . 0.0 . 42 7 N 10 10 10 10 10 10 10 10 10 10 10 10 10 . 10 10 . 10 CODE 67 - MEAN 12.90" 6.70e- 15.936- 45.00 67.2"+ 24.43 35.44 69.3 3.2"t 23.6 0 1 2 0 70+ 1 0 1 0 28° 406 6"+ (PM0) SU 2.51 0.60 1.42 3.74 4.1 3.78 1.28 6.6 2.8 6.6 . 0.4 . 1.7 . 1.8 . 0.5 . 0 5 . 85 8 N 47 47 47 47 47 47 47 47 47 47 47 47 47 47 . 47 . 47 s= statistically s-Tgnificantly higher (a+) or lower (a-) than control value as measured by a student's t-test at p<0.05 - - - C96ZOYOB
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TABLE I CON'T ".i SIRTMRY OFHEMATOLOGY DATA AT 600 DAYSEXPOSURE GROUP CODE 33 MEAN (CONTROL) N0 . CODE 13 MEAN (LOW) SD N CODE I1_ MEAN (MID) SU N CODE 68 MEAN (PVIO CONTROL) SDN CODE 67 MEAN (PM0) SO N IIBC RBC HG SEG. BAND ATY B (X10f1fi1)(z1o/FPI) (GfuL) HCT (%) MCV (U) MCH (UUG) MCHC (G/DL) NEUTRO (X) NEUTRO LYMPH (%) _(S . LYMPH ONO OS ASO RBC PLATELETS ) (%) (X) (Z) (%) (X) -Cx 10/MM). 10.30 6.99 2 07 0 56 16.64 48.02 68.4 23.81 34.85 61 9 3 2 2 . . 27 27 1.38 5.81 6.3 0.81 2.37 . 7.7 . 3 8 8.6 8 0.4 3.2 2.7 0.0 0.1 316 8 27 27 27 27 27 27 . .1 0.9 2.2 2.4 0 0 0 3 . 116 5 27 27 27 27 27 . 27 . . 27 27 15.13" 6.39 - 15.41a 44.44e- 69 5 24 13 3 't 3.67 0.44 - 1.09 2.88 . --3 2 . 0 84 4.67 0 99 64.2 5.3 26.2 0.3 2.4 1 6e 0 ek 37 37 37 37 . 37 . 37 . 37 9.2 37 3.2 8.8 0.8 2.6 . 1.5 .0 0.0 0.3 0 7 392.2 82 2 37 37 37 37 37 37 . 37 . 37 16.14ft+ 6.52°- 15.658- 44.32a- 67.9 24 00 35 32 8t 4.09 0.45 1.14 2.89 2 3 . 1 03 . 1 14 65.2 5.4 23.18- 0.8 3.6 1.8 0 0 0 4 a° 41 41 41 41 . 41 . 41 . 41 7.9 41 4.8 9.2 1.1 2.2 1.6 . 0.2 . 0 8 434.0 104 41 41 41 41 41 41 . 41 .8 41 ]4.29a+ 6.41- 4 50 0.48 15 600- °- 44.168- 68.9 24.22 35.31 63.3 1" 7 24 5 8- . 1.31 3.29 2.5 1 08 0 85 . . 0.6 3.1 1.4 0 0 0 4 4 "+ 35 35 35 35 35 . 35 . 35 8.6 35 5.4 8.3 1.0 2.4 1.6 . 0 0 . 0 7 02.1 132 9 35 35 35 35 35 . 35 . 35 . 35 8.85 6.81 1 75 0 32 16.75 50.85 14.1 24.56 32.91 61.2 1 4 29 6 . . 10 10 0.72 2.79 2.9 0.57 0.92 5.8 . 2 0 . 5 0.0 4.4 3.2 0.2 0.2 417 0 10 10 10 10 10 . .7 0.0 1.8 1.1 0.4 0 4 . 7 10 10 10 10 10 10 10 . 10 3.5 10 15.54" 6.74 5 84 0 63 16.41 44.07®- 65.1e- 24.35 31.22" 69.18+ 1 4 2 4s- e" - . . 37 37 1.49 3.77 3.8 1.49 1.91 7 8 . 2.5 4. 7 9 0.2 2.4 2.3e 0.0 0.4 461.0 37 37 37 37 37 . 36 . 0.6 1.6 1.5 0.0 0 7 111.0 36 36 36 ' 36 36 36 . 36 37 s• s[atist3cally siynlflcantly higher (®r) or lower (a-) than control value as measured by a student's t-test at p<0.05 t I- V3G40V0R
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..u.. a.r Aft ,m J" NAA +r.r r..r TABLE I CON'T SLO#IARY OF HEMATOLOGY DATA AT 800-DAYS-EXhOSURE NBC RBC HGB HC T MCV SEG. BAND ATY. GRuUP (X10f144)(X10/MM) (G(DL) (X MCH ) (U) (UUG) MCHC (GjOI) NEUTRO (X) NEUTRO LYMPH L_YMPH MONO EOS BASO NRBC PLATELETS (%) (Z) (X) (Y) (E) (Zj M (%10/MM) ~ CODE 33 (CONTROL) MEAN SD 10.35 7.12 2.01 0 68 16.71 46. 1 35 81 65.6 23.47 ' 35.70 61.5 3.6 31.1 0.0 0 8 3 0 0 N . 36 36 . 3. 36 70 2.1 0.84 36 0.69 10.3 2.6 10.9 0.2 . 1.3 . 2:5 .0 0 0 0.2 0 370.4 36 36 36 36 36 36 36 36 36 . 36 .5 36 68.5 36 CODE 13 (LON) MEAN 50 16.938F 6.50"- 4 28 0 69 15.328- 42.8 1 79 68- 66.0 23.56 35.75 69.4g~ 5.3 21.58- 0.38- 1 2 1 8 N . . 33 33 . 4.8 33 - 3 2 2.5 1.07 3 0.99 9.2 5.0 9.1 0.6 . 1.1 . 4 2 0.0 0.0 0.7 389.5 33 33 33 33 33 33 33 33 . 33 33 2.1 33 81.6 33 CODE 11 (MI 0 ) MEAN SO 15.59"+ 6.178- 3 49 0 54 14.718- 41.3 1e- 66.88* 23.81 - 35.39 71.4" 4.6 20 3"- 0 1 2 8* - _ _ N . . 35 35 1.33 3.6 6 2.4 0.69 0.98 9.3 4 4 . 6 0 . 0 2 .3 1 8 1.3 0.0 0.5 428.7e? 35 3 5 35 35 35 35 . 35 . 35 . 35 . 35 1.7 35 0.0 35 0.8 35 71.1 35 CODE 32 (HIGH) MEAN SD 14.50" 6.14-"- -2.69 0.58 14.328' 41.1 1.30 3.5 3"- 67.00" 23.33 1 2 6-0 87 34.796- 69.6a+ 3.8 23.98- 0.0 1.3 1.5"- 0.0 0 1 395 6 .o N 26 26 26 2 . _._ 6 0.70 8.8 4.2 9.8 0.0 1.5 2.2 0 0 . 0 . 26 26 26 25 25 25 25 25 25 . 25 .3 25 73.1 26 CODE 68 (P6I0 CONTROL) MEAN SD 10.97 6.39 2.44 0 50 15.50 45.40 1 16 70.5 24.23 34.14 65.8 1.2 25.2 0.2 4 9 2 7 0 0 N . 10 10 . 3.86 10 10 1.3 0.41 0.69 10.3 1.9 8.2 0.4 . 4.1 . 2 6 . 0 0 0.1 0. 384.0 10 10 10 10 10 10 10 10 . 10 . 10 3 10 141.5 10 CODE 67 (I'MO) MEAN SD 11.83 6.35 2.20 0 52 15.40 45.47 1 28 3 71.1 24.20 - 33.82 68.6 1.6 22.8 0.0 4 9 2 1 0 N . 34 34 . .50 34 34 2.8 0.01 1.12 8.8 1.7 8.7 0.2 . 2.6 . 2 2 .0 0 0 0.4 . 351.9 34 34 34 34 34 34 34 34 . 34 . 34 0 9 34 63.5 34 a= statlstically s officantly higher (et) or lower (a-) than control value as measured by a student's t-test at p<0.05 N-1 qJUCsO V VR
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11.J u ~..1 wj TABLE I CON'T SUM4ARY OF HEMATOLOGY DATA AT 1000 DAYS EXPOSURE WI1C RDC IIGB HCT MCV MCH MCHC SEG. NEUTRO BAND NFUTRO LYMPH ATY. LYMPH MONO EOS BASO NRBC PLATELETS GRUUP (XIO/r4M)(X10/MM) (G/DL) (X) (U) (UUG) (G/DL) (X) M (S) (S) (X) (%) (X) (X) (X10(t1T4) CODE 33 MEAN 11.17 6.74 16.25 44.23 65.3 24.08 36.67 68.1 0.9 25.5 0.2 3.7 1.7 0.0 0.5 342.7 (CONTROL) SU 3.89 0.59 1.56 3.51 2.5 0.93 1.33 6.7 1.1 7.3 0.5 1.9 2.0 0.0 0.8 55.8 N 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 CODE 13 MEAN 15.79°+ 6.17° 15.138- 42.418- 68.5a+ 24.50 35.69"- 70.8 2.00' 22.6 0.1 2.68- 2.0 0.0 0.5 404.38* (LOU) SO 3.93 0.41 0.95 2.87 3.6 0.79 2:07 7.0 1.5 6.4 0.3 1.6 1.4 0.0 1.0 71.9 N- -28 28 28 28 -28 28 28 28 28 28 28 28 28 28 28 28 COOE 11 MEAN 15.05" 6.07- 15.058- 42.45 69.5" 24.75"+ 35.47H 67.9 3.1"+ 24.0 0.4 2.9 1.6 0.0 0.9 466.2" (1410) SU 2.61 0 .49 1.29 3.82 3.7 0.71 1.87 8.5 2.5 -8:5 1.1 1.6 1.6 0.0 1.4 73.2 - - N- _ 32 32 32 - 32 32 32 32 32 32 32 32 32 32 32 32 32 ~ CODE 32 MEAN 14.34" 6.118- 15.078- 41.76e- 68.08" 24.65a+ 36.06 66.1 1.3 25.2 1.2" 3.2 3.08' 0.0 0.6 385.69± (Ilfcif) SD 3.18 0.53 1.18 2.86 3.8 0.65 1.97 6.8 2.2 6.8 1.9 1.8 2.5 0.2 1.0 8 3 .8 i N 25 25 25 25 25 25 25 25 25 25 _25 _25 25 25 25 _ _ 25 CODE 68 MEAN 9.55 6.61 15.84 47.05 70.9 23.92 33.60 63.3 0.0 28.9 0.0 4.1 3.7 0.0 0.3 284.0 (Po•10 CONTNOL) SD 1.41 0.44 1.02 2.55 1.9 0.70 0.56 8.4 0.0 8.6 0.0 2.3 2.8 0.0 0.7 29.7 N 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 13,20" 6.22''- 14.89 43.715- 69.9 23.92 34.00 73.45* 0.7Sb 19.8'S- 0.45*' 3.8 1.9 0.0 0.5 225.6 (PMO) SO 2.57 0.53 1.34 3.56 2.2 1.18 1.07 6.6 1.1 6.6 0.7 2.2 1.6 0.0 0.7 58.8 N 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 31 e= statistically significantly higher (ae) or lower (a-) than control value as measured by a student's t-test at p<0.05 4 y9G,ZOtiUW
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I~.J +~J 1r,.J TABLE I CON'T _S_U_M_!M_ RY OF HEMATOLOGY DATA AT 1200 DAYS EXPOSURE SEG. BAND ATY. NBC ROC IIGB NCT MCY MCII MCMC NEUTRO NEUTRO LYMPH LYMPH MONO EOS BA50 NRBC PLATELETS GROUP (X10/IR4)(X10/MM) (G(UL) (X) (U) (UUG) (G/DL) (X) (%) (%) (%) (%) (%) (%) (%) (X107MM) CODE 33 MEAN 9.43 6.73 16.30 48.28 71.3 24.21 33.72 64.6 0.5 21.1 0.0 4.7 3.2 0.0 0.1 397.6 (CONIROL) S0 2.25 0.47 0.94 2.75 2.6 0.85 0.73 9.2 1.0 9.2 0.0 2.7 2.1 0.0 0.3 68.2 -- N 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 MEAN 12.92"r 5.88"= 14.84" 43.525- 73.5°f 25.22''l~ 34.12 65.3 0.7 25.3 0.4S+ 5.5 2.9 0.0 0.5St 433.4 SD 3.12 0.54 1.29 4.52 2.8 1.02 1.40 8.3 1.5 8.3 0.8 3.0 2.3 0.0 0.7 76.6 N 28 28 28 28 28 _ 28 28 _28 28 28 28 28 28 28 28 23 CODE I1 MEAN 13.13'Sk 5.88`- 14.64'S- 43.285- 72.9 24.815* 33.87 69.0 0.9 23.8 0.5S+ 3.2 2.6 0.0 0.5S+ 452.8 (M1U) SD_ 2.48 0.44 1.31 4.63 4.3 1.04 1.65 7.0 1.0 6.9 1.0 2.7 2.2 0.0 0.7 117.2 N 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32 32 CODE 32 MEAN 11.405` 5.915- 14.175- 42.485- 71.3 23.92 33.35 67.5 0.9 23.2" 0.8 5.0 2.5 0.0 0.4 351.25- ~ (IIIGII) SD 1.88 0.49 1.40 4.06 2.8 0.97 1.46 4.8 1.1 5.2 1.6 2.8 2.0 0.0 0.8 79.5 t~ N - 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 24 N I 1100 DAYS EXPOSURE CODE 68 MEAN_ - 8.78 6.78 16.61 49.25 72.1 24.46 33.68 71.4 0.4 22.5 0.1 2.9 2.7 0.0 0.1 373.6 (P1 •10CONTIfUL) Sli 1.35 0.26 0.62 1.74 1.2 0.39 0.33 7.8 0.7 8.4 0.3 1.4 2.2 0.0 0.3 117.7 N 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 12.84"} 6.08'S 14.205- 42.45S- 69.3'- 23.30"- 33.40'- 72.6 0.2 22.0 0.0 2.6 2.6 0.0 0.4 290.5 (1410) SD 3.09 0.43 1.11 2.93 2.3 1.10 1.04 6.9 0.5 7.9 0.0 1.8 1.6 0.0 0.6 83.8 N 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 30 -- - s= statist~al9y 31g~#7lcantTy fifgfier s• or lower (s-) than control value as measured by a student's t-test at p,0.05 C: y J 4 . f'='1 .._•~ ~-*96z0V0R
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SEG. BAND ATY. N8C ROC IIGB IICT MCV MCII MCNC MEUTRO NEIIIRO LYMPII LYMP11 MONO E0S BASO NRBC PLATFLETS GROUP (x10/IM/)(R10(MN) (G/OL) (z) (U) (uuG) (G/DL) (x) (s) (x) M Ix) (x) (z) (x) (x1olMM) CODE 33 MEAN 10.00 6.53 15.80 46.24 70.2 24.13 34.15 64.2 0.1 24.2 0.0 5.0 6.4 0.0 0.4 330.9 (Cng niOL) So 1:92 0.77 1.85 5.63 2.4 0.71 0.68 8.8 0.5 8.5 0.2 3.3 3.2 0.0 0.7 43.8 N 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 CODE 13 MEAN 15.00'+ 6.02'S- 14.385- 42.855- 70.6 23.86 33.54s- 71.7 s+ 0.5 s+ 19.BS- 0.5S+ 4.6 2.7 0.0 0.2 354.2 (LQW) SD 3.93 0.52 1.19 3.65 2.1 0.92 0.80 6.5 0.9 6.4 0.9 2.7 2.2 0.0 0.5 69.6 N 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 26 COOL 1I 1fEAN 14.B5'S+ 6.07S- 14.42s- 43.07 117 70.5 2 3.695- 33.42'S- 72.45+ 0.5S+ 20.0 0.55+ 3.4S- 3.25- 0.0 0.4 3i4.5'S- ..(MIU) SD 2.80 0.44 1.11 3.23 1.6 _ 0.66 0.42 7.1 0.7 6.5 1.0 1.5 2.2 0.0 0.8 117.9 N 28 28 28 28 28 28 28 28 28 28 28 28 28 28 29 28 CUDL 32 MEAN 13.085l~ 5.88s- 14.045 41.485- 70.1 23.83 33.81 71.45+ 0.3 22.7 0.1 2.3s- 3.1s- 0.0 0.3 314.0 ~ s~ (IIIGII) SD 3.31 0.52 1.20 3.60 1.8 0.75 0.85 5.9 0.8 6.0 0.3 1.5 2.8 0.0 0.6 89.9 w 11 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 CODL 68 (/1,li)-i:DNTIiOL) CODE 67 MEAN S0N MEAN ..(1'140) SO N s=-sl.atTs..ct~1-aTTy Tnificantly higher (s+) or lower (s-) than control value as measured by a student'i t-test at P~0.05 TABLE 1 CON"T SURfIARY OF HEMATOLOGY DATA AT 1400 DAYS EXPOSURE &7U[~.OYOR
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MEAN SD N WBC RBC (xl0/MM)(x10lMM) TABLE 1 CON'T I SUIYIARY OF IIEIIATOLOGY DATA AT 1500 DAYS EXPOSURE SEG. BAND ATY. IIGB IICT MCV MCH MCI16 NEUTRO NEUTRO . .. LYMPH . LYMPH MONO E05 BASO NRRC PLATEIETS - (G/DL) (x) (U) (UDG) (G/0L) (x) ( x) (x) (z) (z) (%) (y;) (%) (z(0/MM) 16.17 48.20 71.2 24.00 33.51 68.8 0.1 24.4 0.0 2.3 4.4 0.0 0.4 359.6 0.97 3.11 2.4 0.79 0.44 6.2 0.3 4.6 0.2 1.7 3.4 0.0 0.7 17.4 23 23 23 23 23 23 23 23 23 23 23 23 23 23 14.385-43.045- 71.4 24.00 33.37 69.3 0.3 24.8 0.1 2.8 2.55 0.0 0.2 393.35+ 1.12 3.38 2.5 0.76 0.47 8.2 0.7 6.4 0.4 2.2 2.3 0.0 0.4 40.9 26 26 26 26 26 26 26 26 26 26 26 26 26 26 14.055-41.7B S- 70.7 23.90 33.59 72.9$+ 0.65+ 20.55' 0.1 3.1 2.9 0.0 0.1 358.5 1.27 3.81 2.0 0.75 0.39 6.9 0.7 6.8 0.3 2.1 2.3 0.0 0.5 112.3 27 27 27 27 27 _27 27 27 27 27 27 27 27 27 14.005-41.805- 70.3 23.68 33.47 69.8 0.3 23.0 0.0 3.4 3.4 0.0 0.2 412.8's+ 1.45 4.44 1.5 0.59 0.41 8.6 0.6 9.8 0.2 2.4 2.8 0.0 0.4 112.7 23 23 23 23 23 23 23 23 23 23 _23 23 23 23 ~-s IFRT;flcelly significantly higher (s+) or lower (s-) than control value as nmeasured by a student's t-test at p<0.05 ~'~E„Z0VOR
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.:. ..j t.,_.J ._.1 +<. _1 .: .:J TABLE 2 SUMMARY OF PLATELET ADHESIVENESS AND AGGREGATION AT 0 DAYS EXPOSURE ADP 2X10 M COLLAGEN 0.26 MGfML GROUP % ADIIESIVENESS PRE EXI'OSURE % ADHESIVENESS POST EXPOSURE PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (% AGGREGATION) PRE EXPOSURE (% AGGREGATION) POST EXPOSURE (% AGGREGATION) ~ ~ i CODE 33 (CONTROL) CODE 13 ..(LOW).. CODE 11 (MID) ODE 32 (111GH) MEAN SD N MEAN SD... N MEAN SO N MEAN SO N a DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON ATA NOT COLLECTED AT BORRISTON e CODE 68 MEAN 90.3 - 62.7 78.0 (PMO C T OL) SO 4.6 - 24.1 6.5 ON R N 6 0 6 4 0 CODE 67 MEAN 76.1 ' 75.1 - 77.2 (PM0) SO 14.2 - 16.9 - 8.1 N 18 -I 18 -1 13 -1 C-3 r" 1 EJ Y~
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TABLE 2 CON'T SUMMARY OF PLATELET ADNESIVENESS AND AGGREGATION AT 100 DAYS EXPOSURE ' ADP 2X10 M COLLAGEN 0.26 MG/ML_ x ADIIESIVENESS Z ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE PO ST EXPOSURE GRUUV PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (X AGGREGATION) (Z AGGREGATION) _ (X ACGRFGATION) CODE 33 (CONTROL) CODE 13 (L0N) MEAN SD N MEAN SD N r a DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON w rn CODF 11 (MID) CODE 32 (LI1G11) MEAN §I) N MEAN SD N .. aa DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON CODE 68 MEAN 81.7 81.0 77.3 74.7 64.5 62.0 (PMO CONIROL) SD 2.1 1.1 8.3 8.3 12.0 16.8 N 3 3 3 3 2 3 CODE 67 MEAN 80.8 83.2 71.5 71.8 79.3 69.0 (f'MO) SD 6.3 6.1 19.2 20.9 11.9 14.5 N 17 17 17 11 9 B [ T-f+fi[ OVf)R
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TABLE 2 COM'T SUMMARV OF PLATELET ADHESIVENESS AND AGGREGATION AT - 200 DAYS EXPOSURE X ADHESIVENESS % ADIIESIVENESS ADP 2X10 M PRE EXPOSURE POST EXPOSURE COLLAGEN 0.26 MG/ML PRE EXPOSURE POST EXPOSURE GRUUI' PRE EXPOSURE POST EXPOSURE (% AGGBEGATION) (X AGGREGATION) (% AGGREGATION) (% AGGREGAIION) CODE 33 (CllN1ROL) MEAN SO N a. DATA NOT COLLECTED AT BORRISTON ae CODE 13 MEAN 68.5 70.5 80.5 80.0 75.0 72.8 (LOU) SD 16.7 19.6 6.8 8.0 0 7.6 N 4 4 4 4 1 4 CODE 11 MEAN 51.5 55.5 88.0 85.0 59.0 83.0 (MID) SD 19.1 7.8 2.8 4.2 26.9 4.2 N 2 2 2 2 2 2 ~ CODE 32 MEAN 64.3 62.0 66.5 68.0 70.5 63.0 ~ (IIICdI) SO 11.3 7.0 17.7 12.8 23.9 33.2 ~ N 4 4 4 4 4 3 CODE 68 MEAN 58.5 56.9 70.0 75.3 58.0 68.0 (PMU CIINTRUL) SD 15.2 6.5 12.8 6.6 2 1.8 5.3 N 8 8 8 8 _ 8 3 CODE 67 MEAN 74.9 76.6 74.1 76.4 55.8 45.4 ( PM(1) SD 8.3 7.8 20.8 21.8 18.3 21.8 N 17 15 15 14 12 11 t"r
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TAOLE 2 CON'T SUMMARY OF PL_ATELET ADHESIVENESS AND AGGREGATION AT 400 DAYS EXPOSURE ADP 2X10 M COLLAGEN 0.26 MG/ML % ADHESIVENESS x AOIIESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE GROUP PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (X AGGREGATION) (S AGGREGAII(1N) (% AGGRCGATION) CODE 33 MEAN 78.4 80.6 72.8 68.6 75.8 72.3 (CONTROL) 50 8.0 8.6• 9.8 18.6 5.9 13.9 N 8 8 8 8 8 8 CODE 13 MEAN 79.3 77.6 70.0 66.3 72.2 74.0 (LOW) SD 9.5 7.8 13.6 22.2 20.5 8.7 N 10 10 10 10 9 9 CODE 11 MEAN 75.7 75.1 68.4 72.4 74.1 74.2 (M10) SO 7.8 6.1 17.1 15.0 6.7 5.7 N 10 10 10 10 9 10 CODE 32 ' MEAN 77.0 78.2 71.2 73.2 64.8 72.7 (IIlfN) SO 6.1 7.0 16.2 16.2 23.7 17.6 ~ w _ N 12 12 12 12 11 11 ~ CODE 68 MEAN 57.4 56.8 74.4 78.5 46.7 47.0 (PMO CONTROL) SD 9.2 5.7 7.2 10.8 26.9 25.3 N 8 8 g 8. 7 8 CODE 67 MEAN 61.5 64.6 68.4 67.9 58.7 49.3 (pM0) S() 12.3 10.8 8.0 17.8 16.5 22.8 N 14 14 14 14 9 8 ~~UZADYUR
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J~ a~ J~i .!! .~ .~ °.~ .~i TABLE 2 C0N'T S1ltMRY OF PLATELET ADHESIVENESS AND AGGREGATION AT 600 DAYS EXPOSURE ADP 2X10_ M COLLAGEN 0.26 MG(ML % ADHESIVENESS % ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE GRGUP CODE 33 MEAN -- PRE EXPOSURE 76.2 POST EXPOSURE 79.4 (% AGGREGATION) 77.0 (X AGGREGATION) 77.5 (% AGGREGATION) 68 3 (X AGGREGATION) 63 7 (_CoNtRQL) SU 9.4 9.7 11.3 12.9 . 21.8 . 24.5 N 10 8 10 8 10 6 CODE 13 MEAN 81.8 82.4 54.7 51.7 46.9 43.2 (LUU) SD 6.9 7.8 14.4 15.0 15.1 20.0 N 9 7 9 7 7 5 CODE 11 MEAN 73.7 73.2 72.4 73.2 64.0 65.0 (Ii10) SO 9.1 10.6 12.0 11.6 20.2 17.9 N 10 9 11 10 9 8 i CUUE 3Z MEAN 73.7 81.3 71.0 73.8 58.4 50.0 W ° (UIUN) SU 11.7 6.4 3.2 7.5 13.8 21.0 ~ N 10 10 9 9 8 8 CODE 68 MEAN 37.1 33.9 54.4 45.6 67.4 53.8 (PMU CUWRUL) 6U 6.8 8.1 12.5 19.8 5.9 14.4 N 8 8 8 8 8 8 COUE 67 MEAN 52.7 50.8 66.8 63.6 69.6 70.5 (PMU) SD 8.1 6.9 11.2 10.5 8.5 4.8 N 13 13 13 13 13 13 C-31 . ~."y ~ -r-_ ~ ~ VLszoVOR
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TABLE 2 CON'T SULHARY OF PLATELET ADIIESIVENESS AND AGGREGATIUN AT -- -- 800-DAYS EXPOSURE-- --- ADR 2Ri0_ M COLLAGEN 0,26 MG7ML X ADNESIVENESS - f ADIIESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE GRi,UP PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (X AGGREGATION) (Y. AGGREGATION) (XAGGREGATION) CODE 33 MEAN 66.7 69.2 72.0 68.7 35.2 22.0 (C_OUFROL) SU 11.1 13.5 3.6 8.3 22.9 16.2 N 6 6 6 6 5 4 CODE 13 MEAN 62.7 66.7 62.6 67.7 59.3 53.0 (LOU) SO 11.7 14.1 6.4 8.2 8.1 12.5 N 7 7 7 7 6 6 COOL Il MEAN 48.1 48.8 69.0 69.4 59.8 57.0 (141U) SU 15.3 18.5 5.1 5.7 6.3 13.1 N 9 9 9 9 6 7 CODE 32 MEAN 64.5 66.5 66.9 63.6 52.0 52.0 a 0 (111G11) SD d 10.9 8 11.4 8 17.0 8 16.9 8 21.2 3 14.0 3 COOE 68 MEA N 53.1 54.1 57.8 61.3 62.6 61.3 (P1'10 CONTHOL) _ _ SI1 9.5 11.1 8.2 6.8 3.9 6.3 N 12 12 12 12 12 12 COOL 67 MEAN 51.6 52.4 38.2 40.7 44.1 56.6 (PIdU) SU 8.5 5.4 .8 16 22.3 20.5 14.1 N 14 14 _ 14 14 9 8 / I- -V- 3LV[.OKVR
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TABLE 2 CON'T SLMMRY OE PLATELET ADHESIVENESS AND AGGREGATION AT 1000 DAYS EXPOSURE ADP 2X10 d COLLAGEN 0.26 MG{ML GRUUP % ADHESIVENESS PRE EXPOSURE % ADHESIVENESS POST EXPOSURE PRE EXPOSURE (% AGGREGATION) POST EXPOSURE (% AGGREGATION) PRE EXPOSURE (X AGGREGATION) POST EXPOSURE (X AGGREGATION) COUE 33 MEAN 58.7 64.7 72.7 70.3 76.3 75.3 (CUIITROL) SD 11.3 8.1 11.1 15.8 3.9 10.3 N 6 6 6 6 6 6 CUDE 13 MEAN 42.5 44.7 56.5 60.2 56.3 66.0 (LOU) Sf) 19.7 22.6 24.6 28.7 26.8 8.0 N 6 6 6 6 6 6 COUE 11 MEAN 59.0 57.3 69.0 71.8 71.1 72.3 (wIU) SU 10 .7 12:3 4:3 4.2 2.2 5.3 N _ 8 8 8 8 8 8 CUUL 31 MEAN 56.6 59.5 49.1 47.9 60.3 50.5 (III6U) SO 20.2 19.1 21.7 26.6 16.9 31.7 ~ ----- N-- 8 8 8 8 8 8 t? COUE 68 MEAN 52.5 43.3 30.4 28.9 43.9 41.8 (PI-10 COHINOL) SD 7.8 14.6 10.7 13.9 7.6 14.0 N 8 8 8 e n 8 COUE 67 MEAN 65.2 60.1 45.4 44.6 51.2 45.0 -(P11U)- SD 9.9 11.0 11.5 12.4 13.8 14.2 N 12 12 12 12 12 12 yf4E>v~~~~
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.. ~ , .. ~' ~..~ ,.... ..~. ra ar W" TABLE 2 C0N'T SUMMAR_T OF PLATELET ADIIESIVENESS AND AGGREGATION AT 1200 DAYS EXPOSURE ADP 2X10 M COLLAGEN 0.26 MGft1L GRUUP X ADHESIVENESS PRE EXPOSURE % ADIIESIVENESS PRE EXPOSURE POST EXPOSURE (X AGGREGAiION POST EXPOSURE ) (S AGGREGATION) PRE EXPOSURE (X AGGREGATION) POST EXPOSURE (% AGGRTGA110N) CODE 33 MEAN 51.2 49.2 50.2 47.2 60.2 62.3 (CQNTRO L) SD 13.4 11.6 12.5 12.6 12.4 3.7 _ N 6 6 6 6 6 6 CODE 13 MEAN 54.7 56.1 57.0 59.6 71.3 69.0 (LON) SD 15.5 16.6 11.6 12.9 3.9 6 .5 N 7 7 6 5 4 _ 4 CODE 11 MEAN 51.0 48.5 25.8 31.6 46.5 48.0 (M1D) so 12.4 10.2 15.2 12.8 1.9 5.0 N 8 8 8 8 4 3 CODE 32 MEAN 47.6 47.3 48.4 51.6 61.3 59.3 p (IIIGN) SD 13.0 15.1 17.7 11.9 8.2 8.0 v N 8 . 8 8 7 8 8 CODE 68 MEAN 54.8 57.9 1100 DAYS EXPOSU~ 27.5 26.4 42.4 42.9 ( PMt) COylR01 ) SI) 12.5 9.2 9.1 12.3 4.8 5.4 _ N 8 8 8 8 8 8 CODE 67 MEAN 57.3 59.8 38.3 35.3 57.1 5 0.55' (PMO) SD 7,9 7.5 12.8 8.5 5,4 _ 8.8 N 12 12 12 12 12 12 s=stat{s[~ca-signlficantly higher (s+) or lower (s-) than control value as measured by a student's t-test at p<0.05 L l+LSZAnVUR
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TABLE 2 CON'T SUMMARY OF PLATELET ADIIESIVENESS AND AGGREGATION AT 1400 DAYS EXPOSURE ADP 2_X10 M COLLAGEN 0.26 MGlML % ADIIESIVENESS % ADIIESIVENESS PRE EXPOSIIRE POST EXPOSURE PRE EXPOSURE POST EXPOSURE GRUUP PItE EXPOSURE POST EXPOSURE (% AGGREGATION) (X AGGREGATION) (% AGGREGATION) (% AGGREGATI6N) CODE 33 MEAN 53.9 54.5 57.5 59.6 62.8 63.8 8 5 (CONTROL) 5D 10.6 • 10.4 4.5 10.8 7.4 . N 10 10 10 10 10 10 CODE 13 MEAN 46.4 54.7 59.0 57.9 69.6 67.8 4 7 (LOW) S8 12.5 12.3 18.0 23.3 14.0 1 . 9 I N 9 9 9 9 9 CODE 11 MEAN 66.7 62.0 47.9 44.4 49.1 49.9 (MID) S0 9.4 13.5 16.7 7.8 15.1 13.4 N 7 7 7 7 7 7 CODE 32 MEAN 63.0 56.8 42.3 40.3 52.9 45.1 ~ ~ (111GI1) SO 8.5 13.0 13.8 8.1 9.6 9.6 c^' N 8 8 8 7 8 8 I CODE 68 MEAN (PMO CONTR01_) SD N CODE 67 MEAN (I'Mll) SO N j cn, cl_n i U-J '"4VZOYl/R
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~ .~~. ~ ~ ~.... .or .t= TABLE 2 CON'T SUMIARY OF PLATELET ADIIESIVENESS AND AGGREGATION AT 1500 DATS EXPOSURE ADP 23(10 M COLLAGEN 0.26 MGIML GROUP i ADIIESIVENESS PRE EXPOSURE % ADHESIVENESS POST EXPOSURE PRE EXPOSURE (S AGGREGATION) POST EXPOSURE (X AGGREGATION) PRE EXPOSURE (X AGGREGATION) POST EXPOSURE (% A6GREGAf10N) CODE 33 MEAN 56.7 59.3 46.7 42.8 49.2 42.5 (CONTROL) SD 11.3 • 10.7 19.0 16.0 3.3 10.2 N 6 6 6 6 6 6 CODE 13 MEAN 56.3 51.2 30.2 33.3 43.5 46.3 (LON) SD 7.6 9.9 10.1 12.4 6.4 8.6 N _ 6 6 6 6 6 6 CODE 1I MEAN 56.0 55.5 32.3 29.7 47.3 41.0 (MID) SD 9.1 6.3 12.5 6.8 9.4 6.5 N 6 6 6 6 6 6 CODE 32 MEAN 52.3 57.4 29.0 31.4 43.5 47.8 i (IIIGO) SD 8_ .1 9.6 9.2 10.2 8.2 11.2 n N 8 8 8 8 8 8 ~ I CODE 69 MEAN (PMO CONTROL) SD . . ...... . . N CODE 67 MEAN (PMO) SD N i G I ,p4f;ZnVUf3
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TABLE 3 SUMVIRY OF SERUM PROTEIN ELECTROPf10R_ESIS AT 0 DAYS EXPOSURE GROUP CODE 33 ALBUMIN (G/DL) R*_ ALPHA 1 (G/DL) ff ALPIIA 2 BETA (GfDL) (G(DL) DATA NOT COLLECTED AT BORRISTON GAMMA (G/DL) ** TOTAL GLOBULIN (G(OL) ** A:G RATIO ** (COIITROL) CODE 13 DATA NOT COLLECTED AT BORRISTON ** ** *e (LOW) CODE 11 DATA NOT COLLECTED AT BORRISTON *" ** ** (M1U) •CODE 32 *_* ±e DATA NOT COLLECTED AT BORRISTON ** *i ee (IIIGII) ~ CODE 68 MEAN 3.19 0.23 1.09 1.43 0.53 3.27 0.99 (Ph10 CONTHOL) . . SD 0.32 .. 0.06 0.13 .... 0.30 0.11 0.43 0.18 N 8 8 8 8 8 8 8 CODE 67 MEAN 3.25 0.29" 1.01 1.49 0.60 3.44 0.96 SI) 0.30 0.13 0.21 0.32 0.14 0.41 0.17 N 59 59 59 59 59 59 59 e- statistically significantly higher (a±) or lower (a-) than control value as measured by a student's t-test at ps0.05 C-m.11) EM =2 ORG(.O YO(3
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TABLE 3 CON'T SUMMARY OF SERUM PROTEIN ELECTROPIIOR_ESIS AT - 100 DAYS EXPOSURE GROUP ALBUMIN (G/DL) ALPHA 1 (G/DL) ALPHA 2 BETA -(G/OL) (G(DL) GAMMA (G/OL) TOTAL G_LOBULiN (GEOL) A:G RATIO CODE 33 .• ee DATA NOT COLLECTED AT BORRISTON .. .~ .. (CONTROL) CODE 13 s. .. DATA NOT COLLECTED AT BORRISTON a .. .~ (LOW) CODE 11 (141U) DATA NOT COLLECTED AT BORRISTON ~ CODE 32 .~ DATA NOT COLLECTED AT BORRISTON ~ (IIIGH) CODE 68 MEAN 3.77 0.19 1.00 1.52 0.55 3.26 1.16 (PI•10 CONTROL) SO 0_._23 0.03 0.09 0.22 0 .12 0.30 0.21 N 6 5 5 5 _ 5 5 5 CODE 67 ' MEAN 3.71 0.20 1.02 1.38 0.51 3.12 1.21 (f 110) SD . 0.33 0.05 0.15 0.19 • 0.12 0.33 0.20 N 54 54 54 54 54 54 54 a• staTls-t c Uyigntflcantly higher (e+) or lower (a-) than tontrol value as measured by a student's t-test at p<0.05 C3 IR6ZnV0R
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TABLE 3 CON'T SUMMARY OF SERUM PROTEIN ELECTROPNORESIS AT 200 DAYS EXPOSURE GROUP ALBUMIN (G/DL) ALPIIA I (G/DL) ALPIW 2 BETA (G/DL) (G/DL) GAMM (G/DL) TOTAL GLOBULIN (G/DL) A:G RATIO CODE 33 .. DATA NOT COLLECTED AT BORRISTON es (CONIROL) CODE 13 MEAN 2.94 0.23 1.14 1.43 0.58 3.39 0.88 (LOW) SO 0.32 0.04 0.20 0.20 0.13 0.37 0.16 N i8 18 18 18 18 18 18 ! ~ CODE 11 MEAN 2.97 0.24 1.20 1.38 0.58 3.41 0.88 i (19I0) SD 0.26 0.04 0.16 0.16 0.15 0.33 . 0.13 1 N 17 17 17 17 17 17 17 I ~ CODE 3e MEAN 3.11 0.23 1.16 1.33 0.62 3.36 0.93 J (FIGII) 50 0.37 0.03 0.13 0.16 0.24 0.30 0.15 ~ N 17 17 17 17 17 17 17 CODE 66 MEAN 3.53 0.21 1.14 1.54 0.51 3.39 1.08 (PM0 CONTROL) SO 0.42 0.06 0.19 0.31 0.10 0.53 0.27 N 7 7 7 7 7 7 7 •CODE 67 MEAN 3.35 0.19 1.02 1.36 0.55 3.17 1.08 (f'I10) SD 0.32 0.05 0.16 0.18 ~ 0.14 0.55 0.18 N 56 56 56 - 56 - 56 56 56 e- statistically significantly higher (e+) or lower (a-) than control value as measured by a student's t-test at p<0.05 6 j ZlV(.eOVVC3
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~., -i.-j=mMAAAAAA M M ja M TABLE 3 CON'T SUMMARY OF SERUM PROTEIN ELECTROPIfORE515 AT_ 400 DAYS EXPOSIIRE --- -- 'GRUUP ALOUMIN (6/OL) ALPIIA I (GfOL) ALPHA 2 (G(DL) BETA (GJDL) GAMMA (G/DL) TOTAL GLOBULIN (GlDL) A:G RATIO CODE 33 MEAN 3.51 0.19 1.00 1.47 0.57 3.25 1.13 (CRIITROL) SD 0.33 0.05 0.15 0.36 0.17 0.59 0.29 N 26 26 26 26 26 26 26 CODE 13 MEAN - 3.22°- 0.21 1.04 1.47 0.68°" 3 39 0 98"- (LOW) sll 0.32 - 0.09 0.17 0:28 0.21 . 0.47 . 0:22 N 45 45 45 45 45 45 45 CODE 11 MEAN 3.11"- 0.18 1.04 1.42 0.59 3 23 0 988- (I11D) SD_ 0.24 0.06 0.14 0.23 0.18 . 0.41 . 0.17 N 46 46 46 46 46 46 46 CODE 31 MEAN 3.33°= 0.19 1.06 1.34 0.54 3.13 . 1 08 s (111GI1) SU 0.28 0.09 0.17 0.18 0 16 0 38 . 0 19 c:o i CODE 68 N MEAN 44 3.23 44 0.17 44 1.08 44 1.57 . 44 0.66 . 44 3.48 . 44 0.93 (P M0 COHTROL) 5D 0.10 0.02 0.17 0.17 0.13 0.26 0.09 N 4 4 4 4 4 4 4 CODE 67 MEAN 3.02"- 0.238' 1.24 1.73 0.64 3.81 80 0 (P110) 5D_ 0.40 '- 0.13 0.16 0.32 0.20 0.50 . 0.11 N 29 29 29 29 29 29 29 e• staFlstlcally significantly higher (ef) or lower (s-) than control value as measured by a student's t-test at p<0.05 I ~:qszoVOR
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ENS rn APR .~ mmmmm AM,MM TABLE 3 CON'T SU6TOIRY OF SERUM PROTEIN ELECTR_0_PNORESIS AT 600 DAYS EXPOSURE GROUP ALBUMIN (G/DL) ALPHA I (G/DL) ALPIIA 2 (G/DL) BETA (GIUL) GAbTUI (G(DL) TOTAL GLOBULIN (GfDL) A:G RATIO CODE 33 MEAN 3.29 0.22 1.04 1.67 0.64 3.58 0 94 (CONTROL) s0 0.25 0.05 0.20 0.36 0.11 0.58 . 0 16 N 25 25 25 25 25 25 . 25 CODE 13 MEAN 3.60e# 0.188 1.04 1.58 0.69 3.47 1.06 t (LOW) SU 0.40 0.04 0.22 0.35 0.19 0.61 0.22 N 37 37 37 37 37 37 37 COOE 11 MEAN 3.35 0.22 1.210" 1.73 0.74" 3.91" 0.87 (1•11D) SD 0.34 0.05 0.10 0.27 0.19 0.46 0.13 N 41 41 41 41 41 41 41 CODE 32 MEAN 606' 3 ® e- g " 1. (H1G_N) SD . 0.49 0.10 0.06 1.02 0.14 1.40 0.23 0.63 0.22 3.24 0.44 1.13 + 0.22 u7 N 33 33 33 33 33 33 33 CODE 68 MEAN 3.32 0.26 0.79 1.57 0.78 3.39 0 98 (%90CONIROL_) SD 0.22 0.13 0.26 0.12 0.20 0.20 . 0 08 N 10 10 10 10 10 10 . 10 CODE 67 MEAN 3.36 0.20 1.088± 1.52 0.58e- 3.39 1 02 (ri~o) sD 0.40 0.11 0.21 0.27 0.18 0.47 . 0.25 N 37 37 37 37 37 37 37 s- statistically sig-nTfTc-antly higher (.+) or lower (e-) than control value as measured by a studeat's t-test at p<0.05 i V17GZA1/ V0C3
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i Al in A A .n .7 ZI .M z A A A__A_ R x TABLE 3 CON'T SUMMARY OF SERUM PROTEIN ELECTROPHORESIS AT 800 DAYS EXPOSURE GROUP ALBUMIN (G/DL) ALPHA I (G/DL) ALPIIA 2 (G[DL)_ BETA (G(UL) GAMMA (G/DL) TOTAL GLOBULIN (GfDL) A:G RATIO CODE 33 MEAN 3.17 0.16 1.08 1.71 0.54 3.54 0.92 (CONiROL) SD 0.26 0.02 0.18 0.32 0.14 0.51 0.18 N 36 36 36 36 36 36 36 CODE 13 MEAN 2.868 0.20et 1.12 1.67 0.75°} 74 3 0 784- (LON) SD 0.36 0.04 0.23 0.30 0.26 . 0.50 . 0.16 N 33 33 33 33 33 33 33 CODE 11 MEAN 2 90"- 8, °+ (MID) SO . 0.28 0.18 0.03 1.18 0.17 1.66 0.25 0.73 0.20 3.76 0.44 0.78"- 0 13 N 25 25 25 25 25 25 . 25 ~ CODE 32 MEAN 2 95- 19H* 8- . 0. 1.03 1.51 0.65 3.39 0.88 o (H1G11) SU 0.28 0.03 0.13 0.25 0.23 0.48 0.14 i N 27 27 27 27 27 27 27 CODE 68 MEAH 3.46 0.31 1.25 1.54 0.76 3 87 0 91 (PH0 CONTROL) S_0 0.49 0.16 0.24 0.24 0.20 . 0.56 . 0.14 N 10 10 10 10 10 10 10 CODE 67 MEAN 3.12 0.28 1.020- 1.44 0.76 3.50 0 90 (FMO) SD_ 0.27 0.12 0.16 0.22 0.15 0.32 . 0.12 N 34 34 34 34 34 34 34 e- stattsttcally significantly higher (e+) or lower (a-) than control value as measured by a student's t-test at p<0.05 53; VRfiZQV()q
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,= M M M M W,,: ~ TABLE 3 CON'T SI1P#1ARY OF SERIRAPROTEIN ELECTROPHORESIS AT 1000 DAYS EXPOSURE GROUP ALBUMIN (GlDL) ALPHA I_ (G/oL) . ALPHA 2 (G/OL) BETA (G/DL) GAM4A (G/OL) TOTAL GLOBULIN (G/DL) A:G RATIO - CODE 33 MEAN 3.24 0.18 0.99 1.67 0.61 3.45 0 97 (CONTROL) 5D_ 0.22 0.09 - 0.21 0.37 0.12 0.52 . 0.19 N 24 24 24 24 24 24 24 CODE 13 MEAN 3.079 0.30"k 0.99 1.79 0.79H+ 878" 3 0 81"- (LOW) - sD 0.25 0.16 0_.21 0.38 0.27 . 0.63 . 0.15 N 28 28 28 28 28 28 28 CODE 11_ M1D MEAN 3.30 0.25e+ 0.93 1.78 0.858+ 3,81®" 0.89 ( ) SD 0.42 0__.14 0.27 0.32 0.28 0.56 0.20 N 32 32 32 32 32 32 32 a COQE 3E MEAN 3.27 0.21 0.94 1.56 0.70 41 3 0 99 n (HIGH) 50 0.24 0.07 0.16 0 36 0.28 . 61 0 . 20 ~-~ N 25 25 25 . 25 25 . 25 0. 25 CODE 68 MEAN 3.67 0.23 1.15 1.34 0.75 3.47 1.07 (Ph10 CONTNOL) 5D 0.36 0.17 0,13 0.27 0.23 0,34 0.19 - _ N 10 10 10 10 10 10 10 COOE 67 MEAN 3.43 O.A3Sk 1.09 1.5757 0.85 3.99'+ 0.88'- (RF10) SD 0.25 0.21 0.26 0.19 0.16 0.37 0.10 N 31 31 31 31 31 31 31 a• sr.atlsttcally slgntFicantly htgher (®+) or lower (a-) than rontrol value as measured by a student's t-test at ps0.05 t. 9RGzoVoR
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,.:. =; _" TABLE 3 CON'T SUMMARY_ OF SERUM PROTEIN ELECTRO_P_IN_)R_ESIS AT 1200 DAYS EXPOSURE _ - ALDIR4IN ALPN1 1 ALPIIA 2 BETA GAlfM TOTAL GLOOOLIN A:G RA110 6ROUf' (G/UL) (G{DL) _ (G(DL) (GjUL) (G/DL) (GlOL) - COQE 33 MEAN 3.13 0.26 t 1.05 1.56 0.82 3.68 0.86 (CUNIROL) SD 0.31 0.09 0.16 0.31 0.17 0.46 0 15 N 23 23 23 23 23 23 . 23 CODE 13 MEAN 3.11 0.26 1.11 1.64 0.86 3.86 84 0 (LQW) sD 0.31 0.12 0.23 0.36 0.26 0.67 . 0.20 N 28 28 28 28 28 28 28 CODE 11 MEAN 3 03 21s- 0 (111__0) SD . 0.26 . 0.04 1.10 0.16 1.57 0.18 0.82 0.16 3.69 0.34 0.83 0.12 N 32 32 32 32 32 32 32 CODE 32 MEAN 3.23 0.38S+ 0.98 1.43 0.76 3.55 93 0 cn N (nIGN) SO N 0.27 24 0.21 24 0.18 24 0.37 24 0.27 24 0.57 24 . 0.16 24 1100 DAYS EXPOSURE CODE 68 MEAN 3.43 0.36 1.06 1.55 0.78 3.75 0.93 (PMII CONINOL) SD_ 0.46 0.15 0.16 0.30 0.14 0.43 0.21 N 10 10 10 10 • 10 10 10 CUU[ 67 - - MEAN 3.10 0.30 0.96 1.54 0.77 3.57 88 0 (Iq!(1) SI) 0.22 0.13 0.19 0.26 0.13 0.32 . 0.13 N 29 29 29 29 29 29 29 - statlstlcally significantly higher (a+) or lower (s-) than control value as neasured by a student's t-test at p<0.05 ~ ...!q ~:9 ~..: ~ ~ 144szQVoR
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TABLE 3 CON'T SUMMRY OF SERUM PROTEIN ELECINOPI(OR_ESIS AT 1400 DAYS E%POSORE -- LI2UUp CODE 33 EAN ALBUMIN (cfoL) 3.26 ALPIIA 1 (G/DL) 0.38 ~ ALPIIA 2 (c/oL) 1.02 BETA (GlDL) 1.54 GAMMA (c/oi) 0.72 TOTAL GLOOIILIN (G7DL) 3.67 A:G RATIO 0.91 (CUNIRUL) 50 0.25 0.18 0.28 0.25 0.16 0.54 0.15 N 23 23 23 23 23 23 23 CUIIE. 13 MEAN 3.28 0.39 1.14 1.785f 0.91Sr 4.225+ 80'- 0 (U Ou) --~--- SD 0.42 0.23 0.19 0.51 0.25 0 78 . 0 19 N 26 26 26 26 26 _._ 26 . 26 CDUE 11 MEAN 3.41 0.285- 1.215{ 1.62 0.85so. 3.955+ 0.87 (MIU) SD 0.51 0.13 0.19 0.22 0.19 0.44 0.15 N 28 28 28 28 28 28 28 CODE 32 I MEAN - 3.475+ 0.36 1.19st 1.67 0.86S+ 4.085+ 87 0 in (II C,II) SO 0.23 0.16 0 27 0.28 0 23 0.59 . 0 16 w I N 23 23 . 23 23 . 23 23 . 23 CODE 68 MEAN (PMO-CURINIIL) SD_ N CUDE ti7 MEAN (Im11)S(fN 7 .= sFatlstlcally ;Ignlflcantly higher (e±) or lower (a-) than control value as measured by a student's t-test at p<0.05 4 RRGzoVoR
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aia, .13i1 ri:ii .-Jz~j M +0 .0 M M M M M m TABLE 3 CON'T SUMIARY OF SERUN PROTEIN ELECTROPIIORE315 AT 1500 DAYS EXPOSURE GRUUP ALBUMIN (G/UL) ALPHA 1 (G/DL) ALPHA 2 (G/DL) BETA (G/DL) GAMMA (G/DL) TOTAL G_L08ULIN (G/UL) A:G RATIO CODE 33 MEAN 3.43 0.37 ~ 0.95 1.46 0.71 3.49 1.01 (LUUIROL) SD 0.31 0.16 0.19 0.33 0.20 0:51 0.22 N 23 23 23 23 23 23 23 COUf 13 MEAN 3.24 0.265- 1.08" 1.68 0.88s+ 3.90St 0.875- (LUU) S0 0.39 0.10 0.19 0.46 0.27 0.77 0.25 N 26 26 26 26 26 26 26 COUE 11 MEAN 3.17s 0.29 1.06 1.49 0.90sf 3.75 0.865- (i+lo) 50 0.39 0.14 0.20 0.19 0.25 0.42 0.18 N 27 27 27 27 27 27 27 i CODL 7[ MEAN 3.015- 0.43 1.05 1.59 0.935+ 3.99~+ 0.785- ~ (IIIGII) SIT 32 0 0 23 0.16 0 31 0.36 0.69 0.18 1 N . 23 . 23 23 . 23 23 23 23 LOl1L 68 MEAN (Phl(1C011IHUL) SD- N COOL 67 MEAN _(ih41)) SD b a-statlstlcally significantly higher (et) or lower (a-) than control value as aeasured by a student's t-test at P<0.05 . . . .. .. .. _._.. ... . _ . . .. , .. . .. ... _ 4.?.=9 GRLZOYU9
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TABLE 4 SLRWIRY 0E_ CLINICAL CHEMISTRY DATA AT 0 DAYS EXPOSURE .~.. .r.... .1=.. ... GROUP BUN (MG/DL) GLUCOSE (MG/DL) CREATININE (F1G/UL) CHOLESTEROL CALCIUM (MG(DL) (MG/DL) PHOSPHORUS (MGfDL) SGOT (MU/ML) SGPT (ML1lML) TOTAL PROTEIN (G/DL) CODE 33 DATA I10T COLLECTED AT BORRISTON (CONIROL ) CODE 13 !+ ** ** DATA NOT COLLECTED AT BORRISTON ~r ** ** (LDw) COOE 11 .. DATA NOT COLLECTED AT BORRISTON r. *. *. (MID) CODE 32 ** .. .* DATA NOT COLLECTED AT BORRISTON ** a .. (111GI1) rn CODE 68 MEAN 14.35 108.38 0.86 176.93 10.74 4.02 20. 11 32.81 6.46 (P6.10 COIITROL) ~ - --....... SU 2.80 8.31 0.15 32.07 0.68 0.53 . 4.27 21.29 0.47 N 8 8 8 B 8 8 8 8 8 CODE 67 MEAN 15.79 108.48 0.75 159.99 10.47 3.75 27.07 38.73 6.70 (('110) SD 4.35 11.52 0.10 24.89 0.57 0.54 8.19 19.77 0.44 N 58 52 58 59 56 55 55 50 59 e- statistically sfgnlflsantly higher (at) or lower (s-) than control value as measured by e student's t-test at p<0.05 ossZoVoR
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6. TABLE 4 CON'T SUlTNRY OF CLINICAL CNEMISTRY DATA AT 100 DAYS EXPOSURE TOTAL BUN GLUCOSE CREATININE CHOLESTEROL CALCIUM PHOSPHORUS SGOT SGPT PROTEIN GROUP (MG/DL) (MG/DL) (MG/DL) (MG/DL) (MG/DL) (MG/DL) _ (MU/ML) (MU/ML) (G/DL) CODE 33 (CONTROL) CODE 13 (LOW) CODE 11 (MID) ~ CODE 32 cn (HIGH) rn .. rr *~r .. DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON rr !R •• aa .. ee RR CODE 6d (P110 CONTROL) MEAN SIl 24.67 106.33 0.60 189.18 10.20 4.63 19.17 48.33 6 80 - N 4.59 9.07 0.07 22.17 0.17 0.80 4.31 9.54 . 0.19 6 6 5 6 6 6 6 6 5 CODE 67 (P140) MEAN 16.90"- 100.19 0.66 165.10e- 10.010- 4.16 32.308' 45 71 6 438- SD N 6.44 54 13.95 0.09 27.65 0.32 0.67 6.08 . 19.02 . 0.29 54 54 54 54 54 54 54 54 ®- statistically significantly higher (e+) or lower (a-) than control value as measured by a student's t-test at p<U.05 tF,G"200V08
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,--j j , '.:+j " A A a1 TABLE 4 CON'T S_I_I!T_1_A_R_Y OF CLINICAL CIIEMISTRY DATA AT - 200 DAYS EXPOSURE GROUP BUN (MG/DL) GLUCOSE (MG/DL) CREATININE (MG/DL) CHOLESTEROL CALCIUM (MG/DL) (MGIDL) PHOSPHORUS (MG(DL) SGOT (MU/ML) SGPT (MUfML) TOTAL PROTEIN (G/DL) CODE 33 (COIIIRDL) .. e. .. DATA NOT COLLECTED AT BORRISTON •. ±r rr CODE 13 MEAN 17.22 95.19 0.75 179.44 10.11 4.03 26.81 39.20 6.33 (LOW) SO 4.31 16.80 0.15 31.00 0.69 0.52 8. 57 18.15 0.37 N 18 10 18 18 17 18 _ 16 18 18 CODE 11 MEAN 16.37 99.61 0.82 179.76 10.42 4.03 42.02 39.42 6.40 UI1D) SD 3.92 9.71 0.11 33.46 0.61 0.53 28.79 18.09 0.40 N 18 18 15 17 17 17 17 18 18 ~ CODE 32 MEAN 14.94 108.03 0.78 181.50 10.08 3.66 31.12 33.56 6.41 ~ (jfIGH) SD_ 3.46 10.45 0.10 24.83 0.41 0.65 7.30 7.12 0.33 ! N 17 17 17 17 17 17 17 17 17 CODE 68 MEAN 16.57 109.29 1.24 160.36 9.77 3.61 26.43 45.79 7.15 (PFIO CONIROL) SD 3.64 14.30 0.41 21.04 0.30 0.48 7.50 11.04 0.68 N 7 7 7 7 7 7 7 7 7 . CODE 67 MEAN 17 44 10 96 848' 0 148 06 9 86 4 300 f °- (P110) 50 . 4.43 . 11.83 . 0.29 . 23.25 . 0.54 . 0.80 28.31 10.63 55.97 15.82 6.44- 0.50 N 52 53 56 53 53 53 52 53 56 e- statistically significantly higher (e+) or lower (a-) than control value as measured by a student's t-test at p<0.05 "-`f;(;[•ll KoC7
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sir AN r 4M TABLE 4 CON=T SUMMARY OF CLINICAL_ CHEMISTRY DATA AT 400 DAYS EXPOSURE GROUP BUN (MG D GLUCOSE CREATININE CHOLESTEROL CALCIUM TOTAL / L) (MG/DL) - (MG/DL) - (MG/DL) (MG/DL) PNOSPNORU_S (MG/Dl) SCOT (MUIML) SGPT (MU/ML) PROTEIN (G DL CODE 33 (CONTROL) MEAN SD 19.71 5 82 105.73 0.75 157.29 10 64 / ) N . 26 10.64 0.12 28.11 . 0 35 3.34 32.04 53.21 6.72 26 25 26 . 12 0.69 12 8.72 2 21.71 0.41 4 26 26 CODE 13 MEAN 23.58"+ 94.00 0 71 (LON) SD 8 84 3 . 159.14 10.218- 28e+ 4 N . 45 1 .32 45 0.10 23.34 0.38 . 0 67 32.35 25.90"- 6.60 45 45 44 . 45 31.17 45 13.51 44 0.42 45 CODE 11 (14 MEAN 18.46 104.09 0 1D) SD 5.93 .72 160.25 10 39 er 4 N 46 9.95 46 0.07 46 26.05 46 . 0.53 .53 0.87 37.38 23.67 34.16® 26.08 6.39H- 0.35 46 46 ~ cn CODE 32 I/IGN ( ) MEAN SD 19.00 5 28 102.59 0.608- 157.92 10 43 e+ ~ r N . 44 13.65 44 0.09 32.65 -- . 0.53 4.19 0 87 36.32 38.§58= 6.53 44 44 44 . 23.08 16.23 0 44 - - - - - - - 44 44 44 . 44 - - - - - - - - - - - - - - - - COOE 68 (H4U CONT80L) MEAN SD 12.50 2 52 101.00 0.85 174.25 8•75 3 38 N . 4 7.57 0.06 21.50 - 0 2 . 0 43 31.00 53.25 6.75 4 4 4 . ~ . 12.9~ 13.05 0.17 4 4 CODE 67 MEAN 17.21"+ 94 76 e+ (fYdO) SO 3.83 . 12 41 0.97- 150.59 10.22"+ 54 3 9 N 29 . 9 0.16 22.44 -0.70 . 0 61 2 .72 41.03 6.84 2 29 29 29 . 5.62 ]0.72 0.77 29 29 ® e stattsticrtly slgnlflcantly higher (e+) or lower (a-) than control value as measured by a student's t-test at p<0.05 4 t CL)G"V MOi7
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r~.J . '0....! w..-.1 _ TARLE.4 CON'T S_UiRMRY OF CLINICAL CHEMISTRY DATA AT 600 DAYS EXPOSURE GROUP BUN (MGlDL) GLUCOSE (MG/DL) CREATININE (MG(DL) CHOLESTEROL (MG/DL) CALCIUM (MG/DL) PtI0SPI10RUS (MG/DL) SGOT (MU/ML) SGPT (MU/ML) TOTAL PROTEIN (G/DL) CODE 33 MEAN 20.10 96.24 1.17 146.30 10.24 3.86 33.20 59.52 7.06 (COwTROL) SU f3.06 13.02 0.31 29.54 0.41 0.94 8.80 18.11 0.66 N 25 25 25 25 25 25 25 25 25 CODE 13 MEAN 18.76 94.19 0.92®- 159.44 10.00®- 4.36®+ 33.78 45.35®- 6.91 (LON) SD 4.30 15.76 0.27 28.17 0.41 0.70 12.93 19.43 0.73 N 37 37 37 36 37 37 37 37 37 COQE 11 MEAN 18.20 96.98 1.06 157.12 9.998 4.24 30.35 47.438 7,22 (1110) 5U 5.19 14.50 0.33 34.27 0.42 0.72 13.17 12.13 0.54 N 40 41 41 39 41 41 40 41 41 CODE 3? MEAN 1L 52 97.06 0.87s- 163.71g+ 10.06 4.27 33.24 44.52"- 6.56H- ~(H1GH) SU 4.76 16.85 0:33 2 7:64 0 ;34 0:67 13.40 12.80 0.45 n N 33 33 33 _ 33 _ 32 32 33 33 33 CODE 68 MEAN 14.60 114.80 0.84 184.50 9.03 3.57 22.00 61.80 6.74 (P410 CONTROL_) S6 2.63 11.32 0.13 2_6.50 0.35 0.45 4.71 2_8.50 0.31 N 10 10 10 10 10 10 10 10 10 CODE 67_ MEAN 15.92 108_86 0.75 172.43 8.90 3.96 41.22Br 59.19 6.78 (Ph10) SU 6.34 17.08 0.34 28.10 0.48 1.27 39.47 13.54 0.42 N 37 37 37 37 37 37 37 37 37 sR stattst~ally significantly higher (a+) or lower (e-) than control value as measured by a student's t-test at p<0.05 ) :.J aW Vl1G"\/ Vl/ R
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i MM MM M M J" M - W-4 , - p"" TABLE 4 CON'T SUMMARY OF CLINICAL CIIEMISTRY DATA AT 800 DAYS EXPOSURE GROUP BUN (MG/DL) GLUCOSE (MG/DL) CREATININE (MG(DL) CHOLESTEROL (MG/DL) CALCIUM (MG/OL) PHOSPHORUS (MG/Dl.)- SGOT (MUfML) SGPT (MU/ML) TOTAL PROTEIN (G(DL) CODE 33 MEAN 17.88 89.08 0.97 151.92 10.25 4.00 26.33 45.13 6.72 (CDtITROL) SD 4.00 12.99 0.15 29.37 0.69 0.68 6.84 21.75 0.49 N 24 24 24 24 24 24 24 24 24 CODE 13 MEAN 16.79 85.30 0.94 157.88 10.32 4.13 36.308' 48.45 6.61 (LOW) Sb 5.13 10.96 0.13 28.01 0.49 0.75 15.50 19.87 0.47 N 33 33 33 33 32 33 33 33 33 CODE 11 MEAN 17.40 94.32 0.94 162.72 10.24 4.07 33.360' 55.92 6.67 (MID) SD 3_.79 9.41 0.13 47.90 0.64 0.63 14.49 64.10 0.50 N 25 25 25 25 24 25 25 25 25 orn 0 CODE 32 (HIGH) MEAN SD 17.63 5.55 96.528* 12.39 --- 0.91 0.15 -- 145.85 33.62 10.06 0.40 3.82 0.56 37.52g± 20.43 45.19 19.90 6.34" 0.55 N 27 27 27 27 26 27 27 27 27 CODE 68 (PbIO COH11tU ) MEAN 15.60 122.00 0.87 168.00 10.60 4.75 72.00 57.60 7.35 L SD 3.72 7.89 0.12 31.38 0.59 0.54 47.79 11.31 0. 88 N 10 10 10 10 10 10 10 10 _ 10 CODE 67 MEA14 16.71 104.97 0.86 162.94 9.465- 4.49 39.35 46.715- 6.645- (1T'10) - SD 4.37 14.01 0.10 36.99 0.66 0.53 8.95 16.50 0.41 N 34 34 34 34 34 34 34 34 34 a- statlstically stgnTflcantly higher (ar) or lower (s-) than control value as measured by 4 student's t-test at p<0.05 C 3 t. J rI SfiFic"".0 VUg
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..1 taw i TABLE 4 C0N'T S_l_R4M__R_Y OF CLINICAL CHEMISTRY DATA_ AT - 1000 DAYS EXPOSURE GROUP BUN (MG/DL) GLUCOSE (MGIDLJ CREATININE (MG/DL) CHOLESTEROL_ (MG/DL) CALCIUM (MG/DL) PHOSPHORU_S (MG/DL) SGOT (MU(ML) SGPT (MU/ML) TOTAL PROTEIN (G/DL) CODE 33 MEAN 15.96 112.17 0.78 160.21 8.88 3.82 39.25 59.50 6.72 (CONTROL) 50 4.11 10.38 0.17 19.94 0.43 0.79 22.86 13.98 0.43 N 24 24 24 24 24 24 24 24 24 CODE 13 MEAN 16.93 107.14 0.75 164.54 8.86 3.79 33.21 63.32 6.96 (LOW) SD 5.22 18.29 0.14 2fi.09 0.46 0.80 11.11 32.82 0.57 N 28 28 28 28 28 28 28 28 28 COOE 11 MEAN 17.28 104.008- 0.78 171.87 8.77 3.91 34.81 55 13 13~t 7 _ (MID) SD 5.29 13.59 0.11 36.82 0.31 0.67 15.15 . 16.41 . 0.45 N 32 32 32 32 32 32 32 32 32 ~ ~ CODE 32 MEAN 14.00 96.48e- 0.79 lfi3.00 8.72 3.64 32.56 54.24 6.71 (DIGN) 51) 3.43 13.58 0.12 49.33 0.33 0.57 8.38 14.82 0.52 r N 25 25 25 25 25 25 25 25 25 CODE 68 MEAN 21.00 119.00 0.06 175.00 10.40 5.06 36.70 78.20 7.16 (PMU CONTROL) SD 4.52 9.94 0.13 22.48 0.91 0.89 16.89 88.97 0.38 N 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 18.58 110.32 0.91 170.48 10.45 4.84 46.81 68.39 7.39 (E'MO) SD 4.15 18.21 0.09 54.15 0.56 0.75 10.10 18.93 0.46 N 31 31 31 31 31 31 31 31 31 a- statistically slgnfficantly higher (s+) jr lower (a-) than control value as measured by a student's t-test at p<0.05 9ClG(..D YQC#
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TABLE 4 CON'T Sl_MNRY OF CLINICAL CIIEMIST_R_Y DATA AT 1200DAYS EXPOSIIRE - GIitAIP @UN (MG/DL) GLUCOSE (MG/nL) CREATININE --(MGlDL) CIqLESTEROL (M9/OL) - CALCIUM (MG/OL) P_I_10SPIIURUS (MG/Dt) SGOT (MU/ML1 SGPT (MU/ML) TOTAL PR0ILIN (/:/bl) CUOE 3.1 MEAN 14.00 112.96 0.91 156.30 9.24 3.90 35.35 63.04 6.83 (Ciil~]N01) SD" 3.71 22.91 .09 0 2_7.93 0.97 0.48 10.55 23.38 0.38 N 23 23 _ 23 23 23 23 23 23 23 COUE 13 MEAN 15.39 97.685- 0.845- 190.54 9.27 4.415< 35.57 56.25 7.00 (tbu) SD 4_.82 17.72 0.10 8fi.25 0. 90 0.72 15.08 28.50 0.58 N 28 28 28 28 _ 28 28 28 28 28 COpI 11 MEAN 15.16 112.62 0.855 160.31 9.48 4.23 39.97 46.665- 6.75 (wIU) SD 3.02 10.93 0.09 42.54 0.78 0.75 16.35 12.52 0.32 N 32 32 32 32 32 32 32 32 32 t C00L 32 MEAN 14.33 107.29 0.87 159.58 9.32 4.29St 38.17 48.045 6.80 ~ N (il(w0) so 4.33 11.52 0.20 52.56 0.62 0.49 8.69 12.15 0.60 N 24 24 24 24 24 24 24 24 24 - ---------------------------------------------------------------------------------------------------- ----------------------------- 1100 DAYS EXPOSURE Cool 6d MEAN 22.00 121.50 1.02 160.50 9.94 4.24 31.00 50.40 7.20 (Iaiu EuUIItuL) SO 4.64 11.32 0. 11 34.52 1.29 0.74 8.86 6.08 0.45 N 10 10 _ 10 10 10 10 10 10 10 COUE 67 MEAN 17.285 103.45~ 0.94 163.45 9.66 4.00 36.59 52.28 6.695- (rrwu) SD 3.53 12.96 0.13 36.53 0.54 0.60 6.52 18.79 0.26 N 29 29 29 29 29 29 29 29 29 .- statlstlcally significantly higher (.r) or lower (a-) than control value as Aeasureo oy a student's t-tesc at p<0.05 C /"sszoVOR
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TADLE 4 C_ON'T S_U__MM_ RY OF CLINICAL CIIENISTRY DATA AT - - 1400 DAYS EXPOSURE BUN GLUCOSE C_REATININ_E CIIOLESTEROL CALCIUM PIN)SPIIORUS SGOT SGPT IOtAL P1201[IN GNUI/I' (MG/DL) (MG/Dl) (MG/DL) (MO/OL) (MG/DL) (MG/l1L) (MU/ML) (MU/ML) (/:{Ill ) COUt 33 MEAN 16.52 104.57 0.97 158.48 10.08 4.27 45.65 63.52 6.97 (CUliluOL) SR 3.68 15.14 0.15 31.20 0.80 0.48 8.13 17.83 0.52 N 23 23 23 23 23 23 23 23 23 EUUL 13 MEAN 15.69 1 14.815} 0.95 163.46 10.31 4.53 40.12 52.355- 7.525{ (lln+) so 3.51 _ 14.80 0.10 25.25 0.87 0.50 8.98 15.39 0.82 N 26 26 26 26 26 26 26 26 26 CIIUI II MEAN 18.68 117.865+ 0.865- 173.75 10.10 . 4.52 46.86 57.32 7.39Sr (Idlll) SU 7.40 12.13 0.14 60.09 0.55 0.99 14.84 13.71 0 .70 N 28 28 28 28 28 28 28 28 _ 28 CUU1 32 MEAN 18.43 116.525+ 1.05 168.26 10 14 4.45 47.39 57.74 7 58'* (Int.lt) 3D.. 6.54 10.38 0.20 84.26 . 0.74 0.87 11.06 12.71 . 0.55 N 23 23 23 23 23 23 23 23 23 Clllll 6,3 MEAN (Poill (01111111L) SD N 6UIIL 67 MEAN (IYIU)- SDa a-. statistically significantly higher (a+) or lower (a-) than control value as measured oY a student*s t-test at p<0.05 i. IRFG-"oVoe
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TA_BLE 4 C_ON'T SUMMARY OF CLINICAL CIIEMISTRY DATA AT 1500DAYS EXPOSURE GNllU1' BUN (H(-,711L) GLUCOSE (MG7DL) CREATININE CIpLESTEROL (MGlOL)-(MGfDI)- CALCIUN (MG7DL) PHOSPHORUS (MO7DL) SGOT (MUlML) SGPT (MU7N1.) IUTA1. PIt01LIN (f/UI) CoDE 33 MEAN 19.91 102.17 0.89 157.61 10.43 4.78 40.61 65.00 6.95 (CiD11tOl) SD 4.90 14.37 0.16 25.40 0.82 0.59 13.11 14.91 0.38 N 23 23 23 23 23 23 23 23 23 CUUL 13 MEAN 21.00 113.27sf 0.92 160.96 9.96s- 4.70 32.50'S- 49.125- 7.17 _ (i0u) SD 4.72 12.57 0.16 25.30 0.68 0.51 9.24 17.48 0.57 N 26 26 26 26 26 26 26 26 26 COOL 11 MEAN 20.11 106.85 1.10S+ 167.59 9.83S- 4.60 40.59 53.07s- 6.94 (rflU) SD 4.95 14.02 0.19 65.15 0.68 0.97 15.21 12.32 0.42 N 27 27 27 27 27 27 27 27 27 cOUL 3[ HEAN 18 78 57st 114 0 83 161 52 9 82S- 4.335- 73.96 49.55"- 7.03 i rn A i (iilril) SD N . 4.80 23 . 9.28 23 . 0.12 23 . 63.18 23 . 0.68 23 0:55 23 -_ 23 11.81 22 0.53 23 CODE 6d MEAN (It1U (0111N0L) SD N CUUE 67 MEAN (1710) $D N a- statistically significantly higher (a+) or lower (a-) than control value as measured oy a student's t-tesc at pe0.05 I Gf6Z0V0R
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..ANu =0 1~ ~1 = 1 TABLE 5 SUrMAR_Y OF PULMONARY MEASUREMENTS AT - - 0 DAYS EXPOSURE - ~..,1 c,Z I- -~ ARTERIAL BLOOD GASES N2 WASI_IOUT VOL. i0 CLOSING VITAL PNASE III MINUTE - 02110 _ - -111-- COIIB I'N PC02 P02 2% N2 VOIUM CAPACITY SLOPE VOIUt•1E GROUP (4) (G/100 ML) (x) (MM IIG) (MM IIG) (ML) (ML) X (ML/KG) (% N2(L) (ML/MIM(Y.G) (.... 1 F . CODE 33 (CONTROL) DATA NOT COLLECTED AT BORRISTON f} ++ f+ +• CODE 13 (LOW) CODE 11 (1110) DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON ~ CODE 32 (HIGH) DATA NOT COLLECTED AT BORRISTON (31 Ln CODE 68 MEAN 94.96 15.59 0.70 7.43 25.50 102.29 5787.00 184.00 17.8 88.48 8.15 205.09 (PIdO CUIITROL) SD 0.92 1.10 0.13 0.03 2.69 10.60 953.61 56.02 4.3 12.26 1.06 44.01 N 10 10 6 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 92.87° 15.41 1.69°+ 7.39 6- 24.28 102.90 6227.62 190.00 18.1 92.99 8.61 228.16 (D140) SD 3.24 1.23 0.56 0.04 3.66 8.98 19.64 17 81.56 6.3 16.20 2:58 99.61 N 61 61 58 61 61 61 _ 61 55 55 61 61 61 a• statistically slgntftcantly higher (s+) or lower (a-) than control value as measured by a student's t-test at p<0.05 i 000COVUR
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I in M M M a,~ rf _J ~_1 ~~ .~~ TABLE 5 CON'T SUMMARY OF PULMONARY MEASUREMENTS AT 100 DAYS EXPOSURE .1m im +m ARTERIAL BLOOD GASES N2 WASHOUT VOL. TO CLOSING VITAL PHASE 111 MINUTE 02HB HB COIIB PI1 -M2 P02 2% N2 V L M CAPACITY SLOPE VOLUME GROUP (S) (G/100 ML) (X) (MM HG) (MM HG) (ML) M X (ML/EG) (X N21L)(ML/MIN/KG) ~ ~ CODE 33 (CONIROL) CODE 13 (LOW) CODE 11 (MID) COUE 32 (HIGH) .r .. . .. •r . .. . DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON DATA NOT COLLECTED AT BORRISTON •r f-f •• •. *R ee rr f! e+ .. rf --_- CODE 68 MEAN 91.23 11.00 1.22 7.42 32.63 81.15 7521.28 213.33 20.7 79.57 7.83 245.07 (PM0 CONTROL) SO 3.01 0.33 0.58 0.02 2.45 14.32 1810.82 79.41 7.5 9.70 1.17 94.48 N 6 4 6 6 6 6 6 6 6 6 6 6 CODE 67 MEAN 91.48 16.311" 1.23 7.40 31.23 83.82 6677.28 229.80 22.8 89.06 13.138+ 309.29 (PH0) SO 2.49 1.54 0.77 0.03 3.71 8.75 1094.96 95.88 7.1 17.18 --- 6.47 120.85 N_ 50 50 49 50 50 50 49 50 50 50 50 50 p- statlstlcally slqnlflcantly higher (a+) or lower (a-) than control value as measured by a student's t-test at p<0.05 R to0eoVoe
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in im " m m =,~-3 ~ l ---~ :J = m m M M A M M TABLE 5 CON'T SUT1_ARY OE_ PULMONARY MEASUREMENTS AT 00 DA S-E POSURE X 2 Y ARTERIAL BL00D GASES N2 WASHOUT VOL. TO CLOSING VITAL PHASE III 111T1UTE 0211B HB C0II8 PH PCO2 PO2 2% N2 V0 UM CAPACITY SLOPE VOIUME GROUP (x) (G/100 ML) _ (Y) (MM NG) (MM NG) (ML) ML n% (ML/kG) (X N2/L) (ML/MI11/KG) CODE 33 (CONTROL) r. DATA NOT COLLECTED AT 80RRISTON r. r. .. .. CODE 13 MEAN 91.66 15.12 2.03 7.43 26.19 96.64 6744.12 125.83 12.8 87.27 19.83 254.42 (LOH) SD 3.30 1.03 0.30 0.04 4.75 13.12 1419.70 50.54 4.8 10.99 10.59 88.55 N 18 18 18 18 18 18 17 12 12 18 18 18 CODE 11 MEAN 93.11 15.36 1.89 7.44 7.86 95.66 7343.89 142.73 2 12.9 95.28 19.84 290.19 (MID) SU-- 1.18 1.25 0.31 0.05 _ 3.22 7.94 1980.66 46.50 3.6 • 18.44 7.42 99.59 Il 17 18 18 17 17 17 18 11 li 18 18 18 COUE 32 MEAN 93.31 15.01 1.79 7.47 26.49 87.91 7713.53 186.43 16.7 100.29 11.56 243.82 (HIGH) SU 1.53 0.91 0.48 0.06 4.66 10.31 2422.06 87.32 6.4 15 38 4.53 101.41 rn V CODE 68 N MEAN 17 91.50 17 17.10 17 1.06 17 7.41 17 17 17 14 30.61 72.76 5455.41 303.33 14 27.2 . 17 89.92 17 17 8.39 296.42 (P140 CONIROL) SD . 3.85 . 1.37 0.45 0.03 3.49 13.47 889.09 58.74 4.7 12.83 2.33 122.51 N 9 8 9 9 9 9 9 9 9 9 9 9 CODE 67 MEAN 92.35 16.12 1.18 7.40 32.16 81.95 6305.188t 246.040- 23.6 89.68 12.94" 304.20 (M10) §D 2.62 1.39 0.57 0.04 3.56 11.80 1075.60 92.29 7.1 15.07 6.04 83.96 N 53 51 50 53 53 53 51 53 53 53 53 53 a• statlst1ca11y slgnlflcantly higher (a+) or lower (a-) than control value as neasured by a student's t-test at P<0.05 4 ZaOCoVoR
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TABLE 5 CON'T SUMMARY OF PULMONARY MEASUREMENTS AT 400 DAYS EXPOSURE ARTERIAL BLOOD GASES N2 WASHOUT VOL. TO CLOSING VITAL PHASE III MINNTE 0211B 118 - - C0118 P PCO2 P02 2% N2 Yq~LUME CAPACITY SLOPE VOLUME GROUP (X) (G1100 ML) (X) (MM NO) (hTl HG) (ML) (ML)- ( ) (ML/KG) (% N2fL)(MLIMINfKG) CODE 33 MEAN 93.30 16.77 0.75 .7.43 27.54 89.41 5653.87 177.08 17.9 84.06 10.31 261.12 (CONTROL) SD 1.60 1.26 0.34 0.03 4.12 13.06 675.21 53.77 4.6 14.86 1.68 101.75 N 25 25 20 25 25 25 24 24 24 24 24 24 E.ODE 13 MEAN 93 18 14.55a 1.11°r 7.388- 32.898+ 96.35 6679.488± 216,07er 21.8®; 84.79 13.82" 277.17 (Low) 50 . - - -1.41 2.07 . 0.54 0.04 4.59 15:89 929.82 65.20 6.1 16.26 5.05 79.12 N 42 42 42 42 42 42 42 42 42 42 42 42 CODE 11 MEAN 92.54 15.68a 1.10e+ 7.398- 30.75°r 90.20 7080.978{ 189.25 18.2 87.07 15.82®+ 304.78 (MID) SD 2.26 1.05 0.52 0.05 4.28 14.58 1389.39 70.91 6.0 15.84 7.47 112.61 N 42 42 38 42 42 42 42 40 40 42 42 42 COOE 32 MEAN 92.34 15.64Q 1.188+ 7.408- 33.54e+ 92.63 7059.76Bt 195.90 19.3 84.69 14.38$' 247.45 (IIIGIi) SD 3.41 1.27 1.07 0.04 5.14 16.21 1832.41 59.01 5.2 15.80 5.44 81.60 N 40 41 38 40 40 41 41 39 39 41 41 41 Orn co CODE 68 MEAN 94.86 16.67 1.61 7.41 31.10 80.08 6390.80 254.00 23.6 84.75 8.05 286.64 (PMO CONIROL) SD 2.68 0.61 0.16 0.03 1.70 13.94 1584:71 82.09 6.5 7.96 1.80 92.61 N 10 10 10 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 92.06 15.970- 2.07 + 7.41 30.79 77.17 6949.09 283.49 26.9 88.58 12.008' 372.708~ (CM0) SO 4.14 1.42 1.06 0.05 3.69 12.63 1205.51 98.49 7.3 12.38 4.20 112.73 N 46 46 44 46 46 46 46 43 43 46 46 46 1 4~ - - s- statistically significantly higher (..) or lower (.-) than control value as 14essured by a student's t-test at p<..05 r'1 C:'l M1 EnUCOVOb?
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I r°r 01" ~ i.a a-- . ~ __J -d rL-4 .ls" _iw .111111111111 .IM im Am a TABLE 5 CON'T SUMMARY OE PULMONARY MEASUREMENTS AT 600 DAYS EXPOSURE ARTERIAL BLOOD GASES N WASINNIT - VUL. T0 OSING CL VITAL PIIASE III MINUTE 0211B IID PRE POST PCO POg 2% N; _ CAPACITY SLOPE VOLUME GROUP (E) (G/100 ML) C0110 (i) C0118 (X) p'1 (MN I~G) ~ (MN 116) (MLI TML % (ML/KG) (X N,/L) (ML/MIN/KG) COUE 33 MEAN 92.07 16.65 1.04 - 7.40 32.74 81.52 5988.89 222.69 22.9 83.45 10.29 260.08 (CONTRO[) SD 2.69 1.40 0.61 - 0.02 2.31 11.05 1210.74 77.54 5.3 16.16 3.39 95.77 N 26 26 25 - 26 26 26 26 26 26 26 26 26 COUE 13 MEAN 92.81 15.42S- 1.56s+ - 7.41 32.33 84.81 6011.41 220.56 22.3 85.64 13.68Sf 265.34 (LOII) SD 1.99 1.10 0.49 - 0.03 3.00 11.47 1006.10 80.96 7.1 15.40 5.48 71.52 N 36 36 36 - 36 36 36 36 36 36 36 36 36 CODE 11 MEAN 92.28 15.63S- 1.62S+ - 7.41 30.475- 78.67 6510.32 218.25 21.9 85.06 15.31St 269.40 (MIU) SO 2.38 1.09 0.69 - 0.03 2.65 8.91 -- 1115.45 84.39 6.7 16.40 6.62 75.15 N 40 40 26 - 40 40 40 40 40 40 40 40 40 I CODE 32 NEAN 92.32 15.705- 1.47$; - 7.41 33.01 80.58 6505.51 206.36 19.85- 83.21 13.87st 301.47 m (il1GII) SD 2.19 1.25 0.59 - 0.03 3.03 10.01 1433.56 84.10 6.1 14.72 5.26 108.23 ~ N 33 32 19 - 33 33 33 33 33 33 33 33 33 CODE 68 MEAN 97.27 16.75 2.17 1.77 7.34 37.73 86.63 5745.80 214.44 19.3 88.28 8.90 301.65 (PH0 SU 1.98 0.72 0.49 0.17 0.10 3.29 12.89 831.73 94.88 9.0 17.61 2.72 74.92 CDNTROL) N 10 10 10 10 10 10 10 10 9 9 10 10 10 CODE 67 MEAN 92.89'S- 16.41 1.485~- 3.455k 7.39 35.55 79.43 6957.97'S+ 267.58 25.0 89.77 14.085} 314.60 (PI•q) S0 5.79 1.49 0.55 1.40 0.07 3.17 13.69 1126.29 82.24 6.4 16.53 7.55 95.74 N 37 37 37 37 37 37 37 37 33 33 36 37 37 ---- S- statistically signlficantly higher (5*) or lower (S-) than control value as measured by student's t-test at p<0.05 . r lJV COVQ9 4 0
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Comm :® M M M TABLE 5 CON'T SUMMARY OF PULMONARY MEASUREMENTS AT 800 DAYS EXPOSURE ARTERIAL BL00D GASES N wASNOUT 0211B IIB PRE POST PCO P0z VOL. T0 2% N CLOSING VITAL CAPACITY PHASE 11I SLOPE MINUTE VOLl1ME GROl1P (X) (G_ l10_0 ML) C0118 (Z) COIID (t) pli (MM I~G) ~ (MM 116) (MLI ML- ~% . (MLfKG) (X N1fL )(ML(11IN/kG) CODF 33 MEAN 94.35 16.75 0.83 0.95 7.41 32.26 79.26 5296.55 204.09 20.8 81.37 _ 10.18 275.72 (CONIROL) SD 3.27 1.34 0.80 0.89 0.04 4.64 10.71 968.36 77.81 6.7 14.07 2.50 113.89 N 24 24 23 22 24 24 24 24 22 22 24 . 24 24 CODE 13 MEAN 93.57 15.32'S- 1.50`S+ 5 47s+ 7.41 31.70 74.85 7100.585+ 185.19 18.2 83.25 13.11s* 332.52 (LhU) SD 3.69 1.77 0.95 2.28 0.03 4.08 9.99 1952.75 77.73 6.1 15.54 5.49 121.10 N 33 33 28 32 33 33 33 33 27 27 33 33 33 CODE 11 MEAN 92.01S- 14.78'S- 1.50s; 4.345+ 7.41 31.17 74.42 7020.505+ 204.85 19.7 84.73 14.965* 331.75 (MID) 50 5.20 1.29 1.30 2.11 0.04 3.34 15.52 1446.61 72.07 -4:9 13.98 5.34 130.29 N 34 34 32 33 34 34 34 34 33 33 34 34 34 CODE 32 MEAN 92 14 92 46$- 53 1 565+ 5 7 42 99 30 75 84 6959 525+ 225 00 20 6 85 65 14 58Sr 343 46 ~ v 0 (IIIGu) SO N . . 4.37 1.25 24 25 . 0.89 24 . 1.93 25 . 0.04 25 . 4.49 25 . 13.24 25 . 1616.14 25 . 63.00 22 . 4.5 22 . 14.76 25 . 7.01 25 . 134.91 25 CODE 68 MEAN 95.60 15.50 1.60 1.28 7.40 40.82 85.91 5568.00 244.00 22.2 84.86 9.40 293.75 (PriO SD 2.33 1.16 0.29 0.44 0.03 5.44 7.78 859.48 86.49 8.7 12.80 3.78 90.15 CONTROL) _ N 10 10 10 10 10 10 10 10 10 10 10 10 10 CODE 67 MEAN 95.14 15.40 1.83 4.6957 7.40 36.21S- 81.18 6248.91 244.21 22.0 89.17 12.31 319.61 . (I'pp) SD 4.32 1.28 0.67 3.36 0.04 4.03 14.45 1189.52 87.58 7.0 18.76 5.48 110.87 N_ 36 - --34 34 34 36 36 36 -- 36 , 19 19 35 35 36 -- - S= statlstically sl9nfficantly higher (S*) or loaer (5-) than control value as measured by student's t-test at p<p.05. a'OOCOVUR
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d.r om TABLE 5 CONIT SUMMARY OF PULMONARY MEASUREMENTS AT 1000 DAYS EXPOSURE ARTERIAL BL00D GASES N NASIN)UT 02110 1i8 PRE POST PCO P0 ~ VOL. T0 2% N CLOSING ~f~LI1ME VITAL CAPACITY PHASE III SLOPE MINUTE YOLIIME crsoUP (%) (G/100 ML) COIIB (~) COIIB (f) pH (1Nf h1G) (!M 1 16) ; (MLI ,_, ____ (ML)-- - -(3) (MI/K6) (T N2/L) (ML/r41_N/KG) CODE 33 MEAN 93.11 16.25 1.59 1.76 7.37 33.62 79.40 5782.16 211.11 20.2 86.27 10.47 314.57 (CDNTROL) SD 4.19 1.56 0.49 0.88 0.09 4.47 17.30 963.78 86.56 6.3 17.99 3.41 105.07 N 24 24 24 24 24 24 24 24 18 18 24 24 24 CODE 13 r4EAN 94.18 15.135- 1.86 5.905+ 7.32 34.68 82.66 6558.595" 201.40 19.6 83.93 15.BOS+ 291.70 (LDII) SD 3.15 0.95 0.52 1.96 0.19 3.06 10.25 1040.86 62.31 5.2 17.10 7.05 90.84 N 28 28 20 28 28 28 28 29 25 25 28 28 29 C_ODE 11 _ MEAN - 93.17 15.055- 1.62 4.57S11 7.35 35.21 83.56 6741.56Sf 185.93 17.2 87.85 15.23S* 330.94 (M1I7) SIY 6.03 1.29 0.60 1.59 0.07 3.56 14.52 1273.49 56.72 4.6 17.94 7.88 110.10 N - 32 32 32 32 32 32 32 - 32 27 27 32 32 32 ~ CDDF 32 MEAN 94.83 15.07'S- 1.72 4.O8S+ 7.39 34.94 88.0554 6365.36 221.50 20.0 86.97 14.645+ 344.82 ~ (III(II) SD 3.32 1.18 0.60 1.13 0.08 3.39 10.23 1396.20 91.44 6.3 15.71 6.65 92.63 ~ N 24 25 25 25 24 24 24 25 20 20 25 25 25 CODE 68 MEAN 78.05 15.84 1.97 2.11 7.41 35.85 72.16 6118.10 261.25 22.0 93.35 7.75 249.69 (PMII SD 16.77 1.02 0.46 0.39 0.11 4.15 15.57 1183.56 80.97 6.3 16.31 1.93 124.06 CONTROL) N 10 10 10 10 10 10 10 10 8 8 10 10 10 CODE 67 MEAN 95.OOS` 14.895 2.09 4.435+ 7.41 37.20 88.49`{ 7339.625+ 247.20 22.4 89.01 13.975+ 322.39 (PPq) SD 3.72 1.34 0.76 0.69 0.06 5.17 17.47 1695.71 80.70 5.7 18.63 5.51 86.52 N 32 31 31 31 31 32 32 32 25 25 32 32 32 S= statistically si9nificantly higper (S*) or lower (S-) than control value as measured by gtudent'3 t-test at p<0.05. f = 900COVOR
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_ ..._.. ~. ~ _ . -- - ,._. J/ in mm- TABLE 5 CON'T . SUMMARY OF PUL1pNARY MEASUREMENTS AT 1200 DAYS EXPOSURE ARTERIAL 6(,Q00 GASES N WASHOUT - - VOL TO CLOSING VITAL PHASE lII MINUTE 02110 IIR PRE POST PCO~ POg . _ 2% N; CAPACITY SLOPE VOLUME GROUP (%) (G/100 ML) COtID (S) C0110 (%) pH (MM 11G) (MM H6) (ML+ ML m (ML/KG) (f NZ/L) (Mlf)11N/KG) CODE 33 MEAN 95.72 16.30 2.08 1.95 7.41 36.35 82.24 5386.66 161.87 18.4 79.57 12.50 2_97.07 (CONTROL) SD 3.43 0.94 0.31 0.24 0.07 5.41 13.22 1013.74 87.65 10.2 22.42 3.82 56.10 N 24 23 23 23 24 24 24 24 16 16 24 24 24 CODE 13 MEAN 96.38 14.865 1.695 4.685+ 7.41 37.72 87.73 6199.335+ 176.67 16.4 85.25 13.12 289.39 (LOl)) SO 2.44 1.31 0.42 1.34 0.04 3.87 11.98 1069.56 83.63 7.5 16.91 5.64 75 .77 N 26 27 27 27 26 26 26 27 21 21 26 26 _ 27 CODE 11 MEAN 95.29 14.705- 1.075 5.095~ 7.39 38.67 83.45 672I.48S* 221.18 19.1 86.67 14.77 343.47S* (MIO_) SD 4.48 1.28 0.47 3.00 0.07 4.99 12.61 1395.20 113.79 8.3 19.17 5.88 89.99 N 31 31 31 31 31 31 31 31 17 17 31 31 31 i CODE 32 MEAN 93.02 14.175- 1.755 3.645+ 7.40 38.17 77.51 6328.00S+ 203.57 17.0 90.27 13.06 337.46 N (IIIGN) Sp 6.02 1.40 0.72 1.47 0.05 _4.14 14.79 1523.64 105.36 8.3 18.40 5.44 111.34 ~ N - 24 24 24 24 20 23 23 - 24 14 14 23 24 24 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 1100 DAYS EXP05URE CODE 68 (PN0 MEAN 70.63 16.77 2.25 2.20 7.45 33.12 56.56 6426.70 206.67 19.2 82.53 7.43 288.37 C0NTR0L) SD 15.86 0.44 0.45 0.33 0.08 3.73 8.50 1445.13 03.22 7.0 15.83 1.66 60.99 N 9 6 10 10 9 10 10 10 9 9 10 10 10 CODE 67 MEAN 82.71 14.20S- 2.14 4.635+ 7.40 32.35 66.845+ 6632.07 210.00 19.3 89.30 10.855+ 284.18 (P1K1) SD 14.28 1.11 0.58 1.01 0.15 4.25 9.35 1327.06 56.17 4.1 20.23 5.11 85.12 H 30 30 30 30 30 29 29 30 • 23 23 70 30 30 -- --- - 5= statistically significantly higher (5}) or lower (S-) than control value as measured by student's t-test at p<0.05. f^ rkr ~ ~ r~-- !,OJcOvQs
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.a.r am a AN TADLE 5 C0N'T SUMMARY OF PULMONARY MEASUREM__ENTS AT - 1400 DAYS EXPOSURE ARTERIAL BLOOD GASES N NASN OUT - - - _ VOL. TO CLOSING VITAL PIIASE III MINUTE 02118 IIO PRE POST PCO~ Po 2% NZ VOLUME CAPACITY SLOPE VOLUME GROUP (I) (G(100 ML) CONB (%) C0110 (X) pN (MN IIG) (MM ) 66 (ML) NL (X (MI/KG) (% N2/L) (ML/h1INlKG) CODE 33 MEAN 92.59 15.89 1.04 1.64 7.37 40.83 87.55 5734.11 217.22 20.5 84.55 11.54 262.93 (CONIROL) SO 5.94 1.18 0.60 0.59 0.06 4.14 16.09 1013.30 89.89 7.8 20.65 3.70 88.56 N 26 26 26 26 25 26 26 26 18 10 26 26 26 CODE 13 MEAN 95 325* 14 30;- 88 1 5 135+ Sf - . . . . 7.39 38.83 91.86 6299.54 212.86 18.3 92.38 13.89 277.42 (LIIW) SD 2.09 1.19 0.38 1.52 0.05 4.58 15.30 981.21 81.31 5.2 26.81 8.60 71.69 N 26 26 26 26 26 26 26 26 21 21 26 26 26 COOE 11 MEAN 94.78 14.43s- 2.38St 5.155+ 7.30 40.23 81.46 6759.07r'+ 193.64 17.0 86.32 13.975+ 313.39Ss (V110) SD 4.28 1.11 0_.51 1.49 0.13 20.50 19.14 1672.03 104.45 8.3 16.41 4.09 90.0G N 26 26 26 26 28 28 26 20 22 22 27 28 28 CODE 32 11EAN 93 08 14 045- 2 15 5 St ;- 5+ . . . .OO 7.38 38.59 75.67 6619.78 234.76 19.6 94.03 13.20 303.82 (IIIGII) SD 7.79 1.20 0.75 1.08 0.04 5.50 15.13 1359.65 86.81 5.6 1 8 .76 6.67 64.93 fl 23 23 23 23 23 23 23 23 21 21 _ _ 23 23 23 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 1500 DAYS EXPOSURE ~ COIIE 33 MEAN 78.00 16.17 2.10 1.66 7.39 35.80 33.40 5648.95 203.12 18.0 86.93 9.93 273.51 w (CFliIIROL) --- - Sh 18.74 0:97 -- 0.37 0.44 0.06 4.59 29.08 1222.22 98 77 8 0 23 31 3 66 74.01 ~ N 22 23 23 23 22 22 22 22 . 16 . 16 . 22 . 22 22 CQUE 13 MEAN 81.53 14.3IIS ~1.92 4.00S-3 7.40 34.75 70.90 6003.27 179 41 15 2 88 01 86 11 242 37 (E(U) SD 13.45 1.12 0.59 1.33 0.06 3.47 15.95 1455.91 . 85.11 . 4.8 . 23.16 . 4.93 . 70.09 N 25 26 26 26 25 26 26 26 17 17 26 26 26 COUE 11 MEAN 83.49 14.055 2.90S+ 5.145+ 7.44 32.635 68.22S6655.22 197.60 18.9 85.39 3.145+ 1 294.41 (IIID) SO 15.02 1.27 1.05 - 1.37 0.11 4.56 14.08 1495.61 102.36 8.1 14.47 _ 6.14 71.91 N 27 27 27 27 -27 27 27 27 25 25 26 27 27 CODE 32 MEAN 90.965+ 14.005 2.29 4.965+ 7.40 34.73 63.145 6282.95 186.45 22.6 93.70 10.90 322.61 (111611) SD 6.42 1.45 0.70 1.63 0.04 5.60 16.42 1439.74 00.09 23.9 23.34 4.61 119.31 N 21 23 23 23 22 23 22 23 23 23 23 23 23 S= statlstically signiflcantly hi9her (S+) or lower (S-) than control values as measured by,student's t-test at ps0.05. 8nllC0VObZ
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TABLE 6 GROSS NECROPSY FINDINGS CODE -33_ 11 - 13 _ 32 _ _. 68_ 61 EYE Papilloma on lower lid 1 Ovoid focus on cornea 1 Corneal opacity 1 1 White raised area on cornea 1 SALIVARY GLAND Congested 2 Left, shrunken 1 Firm 1 Enlarged i THYROID Clear cys_t 3 ~ Enlarged 2 3 1 .P Small 1 Round borders 1 White pinpoint foci 1 3 3 1 1 Firm 1 Raised white area 1 White discoloration 1 HEART Enlarged 3 2 Coronary arteries accentuated or distended 2 3 1 Bicuspid value thickened Walls thickened 2 2 3 1 2 Dark red areas I Pale yellow areas or discoloration 2 Yellow streaks on wall I Discoloration of the muscle of the wall 1 4 White areas 1 Pinpoint hemorrhagic foci _ I Distended and irregular in shape 1 S0JepvpB
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i1 TABLE 6 CON'T GROSS NECROPSY FINDINGS HEART -. CON'T Left A.V valve thickened at luminal surface - Large masses in ventricles Pericardium hemorrhagic foci Possible parasite on outside surface LUNGS Soft white streaks Small lobe(s) Atelecsis Dark red or dark red foci All lobes dark green Enlarged Right apical and/or left cardiac lobes white purulent covering Bright red spotting - Grey firm raised a_rea_ Red discoloration White lobes or white area(s)/foci (areas) Consolidation Small pinpoint cyst or nodules Firm granular area, some raised Black foci Firm or rough granular white or grey area Firm lobes Firm nodule or nodule(s), some raised Adhesions Scar-like area with firm consistency Pinpoint dark red foci Greyish-white (areas) Cyst-like areas Reddened or blue areas_ or foci Congested Firm areas, some clear NoJule(s) Greenish-or greyish-brown discoloration CODE _33_ .11_ 13 32 68 1 1 1 1 1 1 1 3 8 F 2 1 2 1 2 2 1 3 1 4 2 1 2 1 2 2 3 4 3 1 1 1 3 2 2 5 1 2 1 1 3 1 3 3 5 1 1 2 1 1 C-3 1 7 Cn 1 1 ~y 1 1 r°"'"~ 3 1 1 2 2 3 = ~ 3 1 1 ~ 1 1 r- 5 2 2 orocovQ'
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ii TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE -3_ 11__ _13- 32 6El 67 LUNG-CON'T eral pleura Thickening of visc I _ Brown i i Hemorrhagic 1 3 Edematous 1 1 Diffuse red areas_ Anthacosis I 1 Mottled 1 ESOPHAGUS Brittle 1 TRACHEA Foam present 1 Red frothy material 1 2 i Mucosa thickened 1 Rough surface near stoma 1 Frothy mucosa 1 i Blood with foam 1 Mucus with blood 2 2 Lesions on lumina 1 Congested 1 Mottled 1 Ilemorrhagi c 1 SPLEEN Mass on border or surface 2 Raised dark and/or red nodule(s) or area 4 1 Siaaa l l White pinpoint material or foci 1 1 2 ~ r.-°a 2 --,. Pink or white streaking 1 ~ 1 Consolidated area(s) 1 Enlarged 4 2 2 3 ~ Raised (white) areas or foci 3 2 4 1 - y 5 Round nodule(s) on surface 1 6 6 4 2 6 White nodules or nodule(s) 12 7 3 2 White pinpoint (Raised foci or white areas) 2 5 1 2 3 R- II0f;QVUe
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,+.r ~ arm arr a. TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE _33_. 68 63 SPLEEN-CON'T ~ Round brown nodule(s) 1 i Raised crust-like areas or lesions 1 2 3 Firm round and raised or white and/or granular nodules 3 1 Greyish-white nodules-lobulated 1 _ Swollen 1 2 Foci 1 Grey raised areas 1 Firm consistency (thickened) i 1 1 White scar (firm) 1 1 Dark red areas on borders 1 White focus on parietal surface 1 Tan coloration 1 2 Dark blue-black 1 Yellow focus 2 Fibrosed i White congested areas 2 ADRENFlLS Cortex accentuated 1 Medulla accentuated 1 Enlarged 2 2 Raised white foci 1 1 1 2 Clear raised cyst(s) 1 White raised nodule-like areas 1 1 Pinpoint brown or red foci 1 1 Raised nodule-like areas 1 1 -- - Clear area(s) 1 Pinpoint nodules 1 1 1 Transparent raised foci White area(s) 1 Round foci ~ 1 Cyst-like lesion 2 Dark red focus 1 4UCpVOR
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~1 I M ~ M Wn TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE 32 68 - 67 KIDNEYS Distinct division between cortex and medulla 1 White coloration 1 1 Dark red focus 1 1 Dark brown streak between cortex and medul la 2 _ _ Yellow and/or brown discoloration Pale I 1 3 Rough area on surface 1 Cyst i Dark red raised foci 1 Left, slightly enlarged 1 Mottled 1 Congested 1 v Fibrous z one 1 m _ Masses 1 Rough surface 1 Shrunken 1 PANCREAS White foci 1 LYMPII NODES Tracheal Enlarged and dark green or black 8 Enlarged and dark red 1 Enlarged 1 1 2 Dark grey 1 Greenish-grey 1 C-3 Bronchial Dark red with white foci 1 Enlarged 1 4 '.2 1 3 Dark red , 3 ~ Dark grey 1 1 Greenish-grey 3 1 1 t- Dark blue-black 1 1 Dark brown I C10COVOR
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~ ~.~..~ r-.~ .~.~ ~.,... ~._.- W:.1 4.4 Aza " M M M M M TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE .-U_ 11_ 13 _ 32 68 b7 LYMPH NODES-CON'T Mesenteric Dark red 1 2 Red 1 Enlarged 1 1 2 1 MEDIASTINAL Dark red 1 Slightly enlarged 1 MANDIBULAR Slightly enlarged 1 1 Dark (red) PANCREATIC Enlarged 1 i 1 Dark red 1 ~ STOMACfI Distended with gas Blood vessel prominant_ i 1 Yellow mucoidfluid 1 Bile 1 White area on pyloris GASTROINTESTINAL TRACT Raised area on duodenal surface I 1 Ileum congested i 1 1 Dark grey streaking of colon 1 2 i Duodenal white raised area Jejunum congested 1 3 2. 1 C-75 Small intestine, mucosa congested and red 1 1 1 c'7 Jejunum and/or ileuni red 1 3 1 1 3 ;- Spherical nodule on jejunum 1 y Duodenal nodule(s) 2~ 2 Jejunum, raised areas 1 ~ Ileum or jejunum appeared hemorrhagic or bright red 3 1 2 4 1 Duodenum, bright red 2 1 lllcerated-like areas on ileum 1 Duodenum and ileinn slightly thickened 1 f"rJeQVO&
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:9 - 1~ ~-~ _''1 ~ J ' ~ ~1L~ ~~p +~ +~ r~ - _ TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE JZ 13 68 67 GASTROINTESTINAL TRACT-CON'T Colon/rectum mucosa slightly folded _ - 2 Black foci on cecum - 1 Appeared small, filled with gas 1 Jejunum, reddened areas on mucosa 1 1 Colon, white nodules on mucosa 1 Rectum, white nodules on mucosa 1 Cecum, enlarged 1 1 Peyer's patches prominent 1 Red with petechial foci 1 Colitis 1 Hemorrhagic 1 Circumscribed area 1 ~ Reddish-blue discoloration i White frothy material I 0 ~ Ulcer between stomach and duodenum 1 Cecwri/colon, dark red streaks on mucosa 1 TESTES Small 3 1 3 Enlarged 1 Congested I Red- I Bluish raised foci 1 Areas of firm consistency 1 Surrounded by brownish-yellow fat 1 Epididyinis enlarged - 1 Epididymis thickened I Thickened 1 C-3 Left, found in abdominal cavity I ~ --~s1-ilLQY~l.3
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~W jo Am in M 4_~ C__~ .1--i ~ X-3 a is A A Ji1 A M M TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE -32 6il- 67 PROSTATE Enlarged 6 4 1 1 1 2 Raised brown irregular areas 1 Dark red areas_ 1 Hemorrhagic 1 Bluish color 1 Right, cystic 1 Small 1 URINARY BLADDER Thickened walls or mucosa 1 2 2 1 7 Filled with white calculi 1 Slightly congested 1 Bluish red near neck of serosal s_ur€ace 1 _ Ulcerated areas on mucosa 1 Mucosa red 1 1 Raised firm red focus 1 LIVER White streaking on ventral lobe of left laterial lobe I Enlarged 1 1 Lobe(s) thickened 1 2 Raised white areas or white areas (foci) 2 1 White scar or scar-like areas 2 White pinuoint spots (or foci) 1 1 2 White firm discolored areas 1 1 Raised brown focus 1 Yellowish-brown 1 C-3 Accentuated lobulation 1 White capsular thickening (areas) 1 ~--i Siderotic nodules 1 Notched lobe borders 4 1 ~ Pale granular appearance 1 --i Capsular thickening 1 r~--s-- Pale yellow 1 Mottled 1 White consolidated areas 1 9TOCQVOR
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TABLE 6 CON'T GROSS NECROPSY FINDINGS GALLBLADDER Mucosal wall thickened Contents bright red_ Grainy Distended with purulent material on mucosal wall Small pinpoint cyst Pinpoint (white) foci on mucosa Nodule with thick contents Raised pinpoint black or grey foci Raised areas Round and creamy white Nodule(s) Mass on mucosa greenish yellow Greyish foci (some raised) 1 Pinlioirit yellowish white foci Black or grey nodules or foci Pinpoint dark red areas or foci 2 Distended Contained semi-coagulated material Thick bile 1 Black bile 1 Bile duct occluded BRAIN Cerebrum congested Blood vessels dilated /lccuirwlation of cerebral spinal fluid PITUITARY Pinpoint cysts, small cyst(s), or clear cyst 1 ldhite foci Congested Reddish color Transparent cyst-like mass Raised area or focus_ 1 Enlarged and cystic Translucent area I-10COVOR CODE 11 13 3_Z 68 67 _ 2 _ 1 1 2 2 I 2 1 2 1 I 1 1 1 2 1 3 1 1 3 1 I 1 1 1 1 1 1 3 4 2 1 I I ~' 1 1 1 1 1 1 1
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TABLE 6 CON'T GROSS NECROPSY FINDINGS CODE ~~ 11 _ _13 32 68 - 67 PARATNYROIDS Enlarged 2 Raised dark focus 1 OTHER Inquinal region contained a subcutaneous hematoma 1 Abdominal region contained a subcutaneous hematoma I Skin of animal appeared jaundice 1 Skin of animal appeared to indicate dehydration 1 Thoracic cavity filled with fl uid 2 Several adhesions between pericardium and lungs 1 &IoeoVoe
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APPENDIX I S_MO_KE EXPOSURE SCHEDULE S11AN CONTROLS GROUP CODE 33 COIIE 13 CODE 11 CODE 32 CODE 67 _COOE 68 SET U1 Ui V1 V2 V3 Xl Xy X3 Y1 • II, Y3 1 2 3 Shalu ** N0. G0G3 PER SE r 12 16 12 17 18 12 18 18- 12 11 17 20 20 20 1o STARTED SMOKE 12-15 12-24 12-15 12-24 12-20 12-15 12-24 '12-20 12-15 12-24 12-20 3-04 4-08 4-18 9-09 TRAINING 76 76 76 76 76 76 76 , 76 76 76 76 17 77 77 77 ATTAINEO FULL 12-29_ 1-07 12-29 1-07 1-03_ 12-29 1-07 1-03 12-29_ 1-07 1-03 4-02 5-06 5-15 9-09 EXPOSURE 76 77 76 77 71 76 77 17 76 77 1? 17 77- 77 77 (12 CIG.IpAY) 1110 DAY Fiif'OSURE • " 10-08 11-11 11-20 12-I7 77 77 77 7) 200 DAY 3-06 ! • 3-13 • ! 3-20 1-16 2-19 2-28 2-19 EXPOSURE 77 77 77 78 78 78 70 400 DAY 6-04 8-23 6-18 7-26 9-22 7-02 8-09 9-29 6-25 8-02 10-06 8-04 9-07 9-16 10-12 EXPOSURE 77 77 77 77 77 77 77 77 77 17 71 78 78 78 78 6(10 DAY 12-21 3-11 12-27 2-04 4-08 1-09 2-25 4-18 1-16 2_-11 4-11 2-20 3-26 4_-04_ 4-30 EXPOSUBE 77 78 72 70 78 78 78 78 78 78 78 79 79 79 79 000 OAY 7-09 9-27 1-15 8-23 10-25 7-28 9-13_ 11-04 B-04 8-30 10-28 9-09 10-12_ 10-21 11-16 LXI'OSURE 78 78 78 78 78 78 18 78 18 78 78 79 79 19 79 10(R1 RAY 1-25 4-15 1-31 3-11 5-13 2_-13 4-01 5-23 2-30 3-18 5-16 3-27 4-29_ 5-08 6-04 EYPOSi1GE 19 19 79 19 79 19 79 79 79 79 79 B0 80 80 80 I/O0 DAY €MPOS(1RE 1_0_-21 4-29 9-12_ 10-I8 80, 80 80 80- 1200 OAY e-13 11-1 8-19 9-28 11-30 9-01 10-18 12-09 8-L4 10-05 12-03 €tROStINE 79 79 79 79-- 7979- 79 79 79 79 79 1400 DAY 4_lll 5-20_ 1-28 4-16 6=17 4-19_ 5-05 6-20 3-26_ 4-22 6-19 €tF!0S(INE 80 -80 0000 0(7 80 80 80 80 8(1 80 1400 DAY 6_-00_ 9_-00 5-04 8-04 9-24 10-24 8-18 11-01 7-07 7-30 ~ 10-12 EAF03(1N€ 8o 80 80 8080 80 80 808080 80 • 0ccu_rred at Oattelle Northwest La6nr-atorles. •• Shan EMpnzed dpgs were rot connected-to machlnes wtth cigarettes. W v L1JCOVI/(3
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APPENDIX 2 ADL-I~D 5MD14INGMACHI~NE Tap 0hive Cam, Pin Bozmm \ Idler Gear Ca'm Shatr. ~. u ! 17J. ,?7ma A-hir. 9meY. ~.ptiTi~ dnwe- frns eb. avu.au ~~.ed dti..n eut~~ imw t9w ttmayo Wb.6ip ~. ~mo*ia[~~ P•mn ia ..aydud..: M 0-rihf i.u..dd far w.Uet: md ..amd~. rm~~ d lubncant...tur.W~~ fa.m N.ip.. pn-. wwt W c4iAi du- to ut..1n rstmsimn m- th. ~.c7iuedlr~h.r inirt utd wNa~~ pan+: tnd li. dts te~.iid. nn .!.t.uwry~...i.i biotk: A.. ~. nw+/L ,.h.e ~.Ih. p~ r+tz.a.• tlw.rlUud ~ir me....d.a uaU7 tL. ~~ IOj.M1 D.t~ iI ./ial.d~, with'tL!. G(YTttI. CCntlL'llm( ~mOtiCn!dff- . pnM SimLLviT: mt.ad;ng Lh.! pia®. Gnt~.a.... th. wtLt wrt to .7iqt otth ~ tttk ~~ieh'.U!uc mb..~~ bKm. ~~tS..mok!. ~~o ~drlv.o wu ,73.. .Gdiep v.l.. 'r~.t.e fiu.d !.tch ~0-rieP~.nd~.. luhnatiae. ria~.~. Piston Pump Khobs 2! Th. Ikiw. A...mhtr- A.Yncheenotu mao. i.d u..d~. f.rpo.., uid ki®in[: On tb..A.R'~i.. dtiw.am ~.nav.d. m'mo.. ~ t6. piam ~ thmesh & pull ryc I1 ~ ua - rr.e.fuuu~ A.wved~ umin. - i. ~Fr.r.dd tu tum~ moe.~. ~io-y tb...h.tL Its hmcton i. to en,t P<b.~. D,utm to~. tN. d-.~ - ~one. ...+T ~JCl..csnd., A~ quR ~ryrJ. meun -Me ~ ed. timiat', am {lrt. . dri.v pis..tttatb.d to Lb. pueq ipto en[a.®ent,.etb tk.~,dnw~ am...At.tAt md!d'tbe~aryelr: th~pm.(.W~.wt~a('enps.men4 .liro.utg tAe d,m. cnm !m ~.ea.u (nef7 vntil tN. ne.t ~7da -85-
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APPENDIX 3 SMOKE DELIVERY SYSTEM I I I 4 3 I I I j C.,~ !~.TraT~. t 4! I~~:~:y l~ 1 Systemit'o deliver smoke to tracheostomized dog. fol'lows the trail of the arrows. (Smoke I 1. Tracheostoma . Z. 3, Cuff'ed' Cannula Inflatable Cuff 4. Trachea 5. T-Tube,Adazter I 6'.One-YJay Va l ve 7:Sinoke Wolding/DeTi'very Tube 8. Cigarette -86-
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I I 11 I ~I I I I f PI APPENDIX 4 CIGA'RETTE AND SMOKE ANALYSIS • Resistance to Draw • Tray Sample Cigarette Weight • TPM of Tray Samples • TPM of Exposure Room Samples • Nicotene Content of Tray Samples • Nicotene Content of Exposure Room Samples r Water Content of Tray Samples • Water Content of Exposure Room Samples • PMO Content of Exposure Room Samples • Machine'Caiibration an IRI Cigarette UN{i j~ENll IAL N
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~ WM „AW JW. JS Jar .rS At JV M A A APPENDIX 4 CON'T PMO CONTENT 0F EXPOSURE ROOM SAMPLES (MG/CIGARETTE) DATE MEAN SD N 6/77 NNNNN NNNNN 0 7/77 N6NNN NNMNN 0 8/77 NN1:i(N NNNNN 0 9/77 4.0 0.37 10 10177 4.3 0.25 25 11i77 4.4 0.35 20 12177 4.1 0.39 15 1i78 4.0 0:37 25 2i78 4.7 0,60 25 3/78 4.2 0.33 20 4<78 4.0 0.78 25 5i7;3 4.3 0.68 19 6/78 4.3 0.56 20 7/78 4.4 0.45 5 9178 NNn:;A NuKNit 0 rn ' PMO CONTENT OF EXPOSURE ROOM SAMPLES (MG/CIGARETTE) DATE MEAN SD N 8/79 4.7 0.45 20 9/79 4.7 0.38 20 10/79 4.6 0.48 25 11t79 4.3 0.39 20 12t79 3.7 0.58 24 1/80 4.2 0.48 20 2/80 4.3 0.68 19 3/80 4.0 1.25 25 4/80 4.6 0.32 20 5/80 4.6 0.33 20 6/80 4.4 1.11 20 C2 7/80 4.6 0.45 19 8/80 4.7 0.53 19 9/80 4.4 0.49 95 10/80 NNHxN NNNXN 0 w E~ .`.~ -i lwGIJ Yog
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APPEFIDIX 4 CON'T MACHINE CALIBRATION ON IRI CIGARETTE DATE MEAN TPM (MG) SD N NICOTINE (MG/CIG.) MEAN SD N 9%78 47.7 4.67 30 3.4 0.29 30 10/78 45.5 34.36 60 3.3 0.27 61 11/78 44:8 4.02 50 3.4 0.23 49 12/78 42.2 4.14 18 3.2 0.22 18 1/79 41.3 2.87 26 3.6 0.34 26 2/79 43.2 2.94 19 3.9 0.53 19 3/79 41.5 1.94 18 3_5 0.40 18 4/79 40.4 2.30 35 3.2 0.25 35 5/79 40.2 2.89 11 2.8 0.29 11 6/79 38.3 4.37 5 3.1 0.41 5 7/79 38.3 5.06 10 2.9 0.38 10 MACHINE CALIBRATION ON IRI CIGARETTE DATE MEAN TPM (MG) SD N NICOTINE (MGtCIG.) MEAN SD N 8/79 NNMNi4 XNMNM 0 NNNNM MItNNM 0 9<7 9 NKNitm N1t)(i1K 0 )txttxal mrwrw 0 10E79 38.9 6.91 23 3.1 0.42 30 11/79 if3tMi1M NMMxi1 0 MkXIfM xrrMx 0 12i79 34.7 3.66 39 2.9 0.45 39 1/80 38.1 4.36 101 3.2 0.35 100 2/80 40.6 3.83 95 3.4 0.28 95 3/80 42.4 4.28 82 3.6 0.41 82 4i80 42.4 4.96 81 3.4 0.44 _ 81 5/80 43.0 4.45 50 3.5 0.50 50 CID 6/80 40.1 2.69 12 3.5 0.53 12 C") 7/80 47.1 6.98 35 3.5 0.33 35 ~ ° 8/80 MXMNM MNMiEk 0 MiINi43f 1MMNM 0 . =2 9/80 45.1 20.94 165 3.3 0.26 165 <'a-3 10f80 NMMi1M NiEki1N 0 MMiflilf xxm><x 0 I F'°a ~ Z_".QCQ VOC3
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.. w,...?,, APPENDIX 5 CON'T HEMATOLOGY DATA CODE 68 EXPOSURE TIME 100 DAYS DOG WBC RBC H¢B HCT MCV MCH MCHC SEG. BAND NEUTRO NEUTRO LYMPH ATY. LYMPH MONO E05 BASO HRBC PLATELET'. N0. (X10/MM) (3X10iMM) (G/DL) (Y,) (U) (UUG) (G/DL) ( :)--- --('/.) ('/,) (4) ('/.) ('/.) (7.) (X) (X(0%MF1) 5039 8.5 7.06 17.3 48.5 60. 24.5 _ 35.7 53 0 38 0 2 7 0 0 290 5046 9.5 6.67 16.4 47:0 70. 24.6 34.9 60 0 33 0. 6 1 0 0 370 5143 9.3 7.63 18.1 49.5 65. 23.7 36.6 66 0 29 0 4 1 0 0 395 6014 11.7 7.23 16.8 46.0 64. • 23.2 36.5 78 0• 18 0 2 2 0 0 350 6016 9.9 6.87 15.8 46.0 67. 23.0 34.3 63 0 32 0 5 0 0 0 330 6039 8.1 6.83 16.7 48.5 71. 24.5 34:4 • 83 0 14 0 1 2 0 0 425 MEAN 9.50 7.05 16.85 47.58 66.2 23.92 35.40 67.2 0.0 27.3 0.0 3.3 2.2 0.0 0.0 360.0 SD 1.26 0.34 0.79 1.46 4.1 0.71 1.02 11.3 0.0 9._3 0.0 2.0 2.5 0.0 0.0 47.9 H 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 w ~~(jIV. nVUR
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APPENDIX 6 PLATELET AD_NESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME 400 DAYS ADP 2_X10 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS 1(ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE ('!. AGGREGATION) (Z AGGREGATION) (Y, AGGREGATION) (i AGGREGATION) 5031 83 83 84 82 82 80 5239 67 69 78 70 72 58 5074 92 89 54 34 76 50 5080 82 89 65 82 70 60 5082 73 68 75 45 70 80 5170 83 87 68 80 78 80 5186 75 76 78 76 72 86 5217 72 84 80 80 86 84 MEAN 78.4 80.6 72.8 68.6 75.8 72.3 SD 8.0 8.6 9.8 18.6 5.9 13.9 H 8 8 8 8 8 8 a w 1 c.40i 0tTOR
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APPENDIX 6 GON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME 600 DAYS ADP 2X10 M COLLAGEN 0•26 MG/ML ANIMAL X ADNESIVENESS X ADIIESIVENESS PRE EXPOSURE P-OST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER _ _ PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (`/._AGGREGATION) (% AGGREGATION) (% AGGREGATION) 5031 80 83 74 82 87 N.R. 5074 89 87 84 77 74 78 5080 76 84 82 89 80 78 5082 71 81 100 98 88 88 5170 85 85 70 68 70 54 5186 75 75 78 78 66 64 5217 79 83 72 56 58 N.R. 5239 59 57 74 72 12 20 5170 84 N.R. 56 • N.R. 70 N.R. 5186 64 N.R.' 80,' N.R. 78 N.R. MEAN 76.2 79.4 77.0 77.5 68.3 63.7 SD 9.4 9.7 11.3 12.9 21.8 24.5 1{ 10 8 10 8 t0 6 VC?V uQiOV
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li .1/-.>i A Ji A A A m m A in A B S APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME 800 DAYS ADP 2X10 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS tiADHESIVENESS _ PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (Z AGGREGATION) (i AGGREGATION) (: AGGREGATTGN) (% AGGREGATION) 5031 71 83 74 70 36 12 5074 84 85 72 72 14 N.R. 5080 72 72 74 72 N.R. N.R. 5082 56 63 76 74 36 12 5217 62 62 70 52 72 46 5239 55 50 66 72 18 18 i MEAN 66.7 69.2 72.0 68.7 35.2 22.0 SD (l.' 13.5 3.6 8.3 22.9 16.2 N 6 6 6 6 5 4 0 qRJEOvUf3
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,,o.r .rrri ir1 in ~ APPENDIX 6 CON'T PLATELET ADUESIVENESS AND AGGREGATIDN CODE 33 EXPDSURE TINE 1000 DAYS ADP 2X10 M COLLAGEN 0.2_ 6(iG[tiL ANIPIAL 'f.ADHESIVENESS :GADHESIVEHESS PRE EXPOSURE POST EXPOSURE PRE EXPDSURE POST EXPUSl1^E NUCIHER PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (i AGGREGATIDN) (i AGGREGATI011) (: AGG';L.",ATION) 5031 55 55 72 80 76 733 5074 72 70 90 80 80 78 5080 41 70 74 84 78 E3 5032 54 55 76 76 80 80 5217 69 74 56 44 70 FS 5239 61 64 68 58 74 70 P1EAN_ 53.7 64.7 72.7 70.3 76.3 75.3 SD 11.3 8.1 11.1 15.8 3.9 10.3 N 6 6 6 6 6 6 4 sRoeoVoR
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A M M M - -- -- - ~ - APPENDIX 6 CON'T PLATELET AD_NESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME 1200 DAYS ADP 2 X10 M COLLAGEN 0.26 MG/11L ANIMAL YADNESIVENESS %ADIIESIVENESS _ PRE EXPOSURE POST EXPOSURE PRE EXP-OSURE POST EXI'OsURE NUMBER PRE EXPOSURE POST Eaf'OSURE (% AGGREGATION) (% AGGREGATION) (': AGGREGATION) (% AGGRCGA(IQII) 5031 47 43 66 60 72 64 -5074 66 56 40 33 64 68 5080 35 51 41 42 55 60 5032 43 32 38 32 40 • Su 5217 69 66 64 47 73 60 5239 47 47 52 64 57 64 tfEAN 51.2 49.2 50.2 47.2 60.2 62.3 _ SD 13.4 11.6 12.5 12.6 12.4 3.7 N 6 6 6 6 6 6 i i.,.l)Oc\/YVN
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-- APPEND(X 6 CON"t ~ PLATELET AD_IIESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME /400 DAYS AFFIMAL '/.ADHESIVEIIESS XADHESIVENESS ADP 2X10 M PRE EXPOSURE POST EXPOSURE C(7LLAGEN 0.26 MG/:1L PRE EXPOSURE POS1 EXI'OSU E NU(IBER PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (% AGGREGATION) (Z AGGREGATION) (G AGGF(EG9Ii0F1) 5031 52 59 54 70 62 70 5031 52 59 54 70 62 70 5074 67 69 62 46 72 64 5074 67 69 62 46 72 64 5080 58 46 62 73 66 70 5080 58 46 62 73 66 70 5082 54 56 58 55 62 66 5082 54 56 58 55 62 66 5217 47 49 50 55 46 54 5239 30 36 53 53 53 44 MEAN 53.9 54.5 57.5 59.6 62.8 63.8 5D 10.6 10.4 4.5 10.8 7.4 8.5 N 10 10 10 1o to 10 ~ib "7UCO VQR
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B -- _ ~ - ------+.~.. APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 33 EXPOSURE TIME 1500 DAYS ADP 2 X10 11 COLLAGEN 0.26 MGitIL ANILIAL %ADIIESIVENESS 'GADUESIVENESS PRE EXPOSURE POST EXPOSURE PRE E::POiURE POST EXIf15UEE NUIIDER PRE EXPOSURE POST EXPOSURE (Z AGGREGATION) (Z AGGREGATION) (2: AGGREGATION) (R Ac;GRf;;ATION) 5031 55 60 50 48 46 22 5074 70 75 62 61 47 48 5080 45 56 62 40 46 411 5032 42 48 60 58 50 47 5217 64 68 20 20 53 4ri 5239 64 49 26 30 53 46 P1EAN 56.7 59.3 46.7 42.8 49.2 42.5 SD 11.3 10.7 19.0 16.0 3.3 10.2 N 6 6 6 6 6 6 t G.`"~ocn vQR
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aO-A ./ ./ A A AM M A A.® .® A AMA AS APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 13 EXPOSURE TIME 200 DAYS ADP 2 .';1,1 M COLLAGEN 0.26 MGtML ANIMAL kADHESIVENESS XADHESIVEHESS _ PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER _ PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (% AGGREGATION) ('!. AGGREGATION) (X AGGkEGATION) 5212 76 85 86 84 75 83 5306 81 84 72 68 N.R. 68 5352 73 70 78 84 N.R. 66 5369 44 43 86 84 N.R. 74 MEAN 68.5 70.5 80.5 80.0 75.0 72.8 S0 16.7 19.6 6.8 8.0 xKyw 7.6 N 4 4 4 4 1 4 f1rU£ovo&
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/lPPENDIX 6 CON'T PLATELET ADHESIVENESS AND_ AGGREGATION CODE 17 EXPOSURE TIME 400 DAYS ADP 2X10 M COLLAGEN 0.26 MG(ML ANIMAL XADHESIVENESS Y,ADHESIVENESS PRE EXPOSURE P05T EXPOSURE PRE EXPOSURE POST EXf'OSURE NUMBER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (: AGGREGATION) (Y. AGGREGATION) (% AGGREGATION) 5041 65 70 82 84 82 72 5050 62 62 48 42 20 N.R. 5125 89 80 90 85 80 82 5135 84 75 74 84 92 74 5169 82 78 56 . 74 N.R. 78 5204 72 73 70 48 78 78 5212 83 82 80 , 80 72 84 5235 84 82 54 78 72 72 5306 88 87 68 20 76 72 5352 84 87 78 68 78 54 MEAN 79.3 77.6 70.0 66.3 72.2 74.0 SD 9.5 7.8 13.6 22.2 20.5 8.7 N 10 10 10 10 9 9 b Tf,UcDvDg
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 13 EXPOSURE TIME 600 DAYS m m ADP 2X'IA M GACEoGEK A.14 Rr.RTC __ _ ANIMAL '.ADHESIVENESS XADNESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE ' NUMBER PRE EXP_D5URE POST EXPOSURE AGGREGATION) ('/. AGGREGATION) (y AGGREGATION) l. AGGREGATION) ( 5041 80 80 38 40 32 34 5125 93 93 38 40 32 34 5135 91 89 54 44 42 N.R. 5169 76 82 80 80 36 20 5204 76 N.R. 62 H.R. 54 N.R. 5212 76 75 42 50 68 68 5235 88 87 70 64 64 60 5352 79 71 56 44 H.R. N.R. 5352 77 N.R. 52 H.R. N.R. N.R. MEAN 81.8 82.4 54.7 51.7 46.9 43.2 56 6.9 7.8 14.4 15.0 15.1 20.0 H 9 7 9 7 7 5 2 t; oEp {,ObZ
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A m APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 13 EXPOSURE TIh1E 800 DAYS ADP 2Xt0 M COLLAGEN 0.26 MGiMI ANIMAL XADHESIVENESS Y.ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPDSURE NUMBER PRE EXPOSURE POST EXPOSURE ('/. AGGREGATION) (% AGGREGATION) (Y, AGGREGATION) (X AGGREGATION) 5041 71 69 52 60 54 54 5125 72 74 72 78 . 70 60 S135 38 38 60 54 64 50 5169 65 65 68 74 N.R. N.R. 5204 68 84 62 70 64 58 5212 66 68 64 68 48 30 5235 59 69 60 70 56 66 MEAN 62.7 66.7 62.6 67.7 59.3 53.0 _ SD 11.7 14.1 6.4 8.2 8.1 12.5 H 7 7 7 7 6 6 i 6 c()il4 U KOC7
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.+.er A.r .ar JW i J= M JW M JK M APPENDJX 6 CON'T PLATELET ADNESIVENESS At{D AGGREGATION CODE 13 EXPOSURE TIME 1000 DAYS ADP 2_X10 M COLLAGEN 0.26 t1G•'t L AIIIMAL 7._ADNESIVENESS XADNESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSU;:E POST EltI'b511tzE NUMBER PRE EXPOSURE POST EXPOSURE (i AGGREGATIDN) (% AGGREGATION) (X AGGREGATION) (i AGGKEGl:1TON) 5041 55 53 76 68 76 68 5125 66 63 72 78 72 70 5135 4i 47 76 80 80 75 5169 51 66 51 76 50 60 5204 10 5 52 54 52 56 5212 32 34 12 5 8 tlf' MEAN 42.5 44.7 56.5 60.2 56.3 66.0 _ SD 19.7 22.6 24.6 28.7 26.8 8.0 N 6 6 6 6 6 5 Vf QCQVOg
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APPENDIX 6 CON'T PLATELET ADNESIVENESS AND AGGREGATION CODE 13 EXPOSURE TIME 1200 DAYS ADP 2_X10 11 COLLRCEN 0.26 FIG:ML ANIMAL Y.ADHESIVEN[SS XADIIESIVEHESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST E,1!'USIIRE NUMBER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (% AGGREGATIDN) (X AGGREGAIIOH) (7. AGGREG'.TIUN) 5041 43 42 64 72 63 69 5125 57 60 55 60 73 7S 5135 41 42 60 HR 76 72 5169 43 45 35 38 I I R L' R 5204 78 85 NR HR HR HR 5212 47 48 68 62 69 60 5235 74 71 60 66 NR UR MEAN 54.7 56.1 57.0 59.6 71.3 69.0 SU 15.5 16.6 11.6 12.9 3.9 6.5 H 7 7 6 5 4 4 v r, f~# ~ ~ 'qi)JE!)KOt3
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 13 EXPOSURE TIh1E 1400 DAYS ADP 2X10 Pl COLLAGEN 0.26 fl;/RiL ANIh1AL XADIIESIVEIIESS ZADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSOfRF PO~T ['Lf'OSL'RE NUIIDER PRE EXPOSURE POST EXPOSURE ('/. AGGREGATION) (X AGGREGATION) (X AGGRE6A H ON) (X AGCCCGf,TI011) 5041 31 36 82 74 82 74 5041 31 36 82 74 32 74 5125 48 60 62 76 77 79 5125 48 60 62 76 77 79 5135 39 51 64 64 77 78 5135 39 51 64 64 77 73 5169 65 68 36 24 50 40 5212 56 61 49 55 56 58 5235 61 69 30 14 ~, 8 50 61EAN 46.4 54.7 59.0 57.9 69.6 67.8 SD 12.5 12.3 18.0 23:3 14.0 14.7 N 9 9 9 9 9 9 r-r1 .~ ~ ~ r~-- :.> 990COV0R
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,a ~ae1 ,ar .~r ,a.r J= is Jo.r .r.. ,,..r .rr ..... J.r i.r Ji.o. ~.r APPENDIX 6 CON'T PLATELET ADNESIVENESS AIID AGGREGATION CODE 13 EXPOSURE TIME 1500 DAYS ADP 2X10 M COLLAGEII 0.26 I'.L ~ ANIMAL 'GADIIESIVENESS Y,ADNESIVEIIESS __ PRE EXPOSURE POST EXPOSURE PP.E EXPOSURE POST E-4I'OSU!?E NUMBER PRE EXPOSURE POST EY.POSURE ('/. AGGREGATION) ('/. AGGREGATI011) (: AGGREGATION) (I., AG;Cf.GATJOlI) 5041 58 39 40 46 40 66 5125 59 52 45 50 40 (i5 5135 43 42 23 34 34 46 5169 60 57 20 28 50 48 5212 53 51 29 20 43 33 5235 65 66 24 22 49 60 P1EAN_ 56.3 51.2 30.2 33.3 43.5 46.3 SD 7.6 9.9 10.1 12.4 6.4 8.6 N 6 6 6 6 6 6 rn N 1 . ~ ~Jf-t ~'Y f C~"1 :a..w ~ ''& cV(. o1/ Q C7
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A,H AN JI. .® in A A A A A Jr A AMR An APPENDIX 6 CON'-T- P_L_ATELET ADHESIVENESS AND AGGREGATION CODE 11 EXPOSURE TIME 200 DAYS ADP 2X10 M COLLAGEN 0.26 MGtML ANIMAL XADNESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE P05T EXPOSURE ('>. AGGREGATION) (L AGGREGATION) (X AGGREGATION) (X AGGREGATION) 5337 65 61 90 82 78 86 5345 38 50 86 88 40 80 MEAN 51.5 55.5 88.0 85.0 59.0 83.0 3D 19.1 7.8 2.8 4.2 26.9 4.2 N 2 2 2 2 2 2 4 R[)V i.oYOs
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 11 EXP05URE_TIME 400 DAYS ADP 2X10 ,~M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS XADNESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXP-OSURE (7. AGGREGATION) (`/. AGGREGATION) (X AGGREGATION) (: AGGREGATION) 5052 72 75 70 78 H.R. 68 5129 81 81 74 82 82 70 5148 79 79 30 34 70 78 5t53 63 63 86 ~ 84 80 76 5165 77 74 62 80 70 80 5233 80 80 74 76 66 66 5237 81 78 84 84 77 82 5261 63 66 68 68 68 68 5267 87 80 52 64 70 76 5337 74 75 84 74 84 78 MEAN 75.7 75.1 68.4 72.4 74.1 74.2 5D 7.8 6.1 17.1 15.0 6.7 5.7 N 10 10 10 10 9 10 ~ ~ V 40I OV
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A.. Ao i..r ,r® irel ,e.N AN ~ APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 11 EXPOSURE TIME 600 DAYS X10 M ADP 2 COLLAGEN 0.26 MGfML ANIMAL Y.ADHESIVENESS X_ADNESIVENESS _ PRE EXPOSURE POST EXPOSURE PRE EXPOSORE --POST EXPOSURE NUh1BER PRE EXPOSURE POST EXPOSURE (Y. AGGREGATION) (Z AGGREGATION) (X AGGREGATION) ('/. AGGREGATION) 5052 86 87 74 76 N.R. 74 5Y29 85 86 74 74 74 70 5148 80 76 52 48 N.R. N.R. 5143 N.R. H. R. 76 62 26 N.R. 5165 66 _ 67 82 84 34 24 5233 76 77 78 82 64 64 5237 70 65 74 64 70 62 5261 68 74 82 82 78 80 5267 79 74 78 80 68 66 5337 57 53 80 80 80 80 526 1 70 N.R. 46 N.R. 82 N.R. MEAN 73.7 73.2 72.4 '73.2 64.0 65.0 5 D 9.1 10.6 12.0 11.6 20_2 17.9 _ N 10 9 11 10 9 8 I v0 ir(eO VQC3
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 11 EXPOSURE TIME 800 DAYS ADP 2X10 M ANIMAL XADIIESIVEHESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (X AGGREGATIDN) (7 AGGREGATION) 5052 67 5129 53 5148 72 5153 52 5165 34 5233 46 5237 35 5267 49 5337 25 MEAN 48.1 SD 15.3 H 9 COLLAGEN 0.26 MGlML PRE EXPOSURE -P05T-EXP05URE ' (Y. AGGREGATION) ('/. AGGREGATION) 69 74 60 H.R. N.R. 59 72 64 60 60 55 58 74 H.R. H.R. 56 66 72 54 58 44 74 70 N.R. 30 57 71 68 69 53 23 72 69 64 64 62 66 68 60 64 14 68 80 52 70 48.8 69.0 69.4 59.8 57.0 18.5 - 5:1 5.7 6.3 13.1 9 9 9 6 7 t r01Co VoR
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AN " " li " " JM AM " " M ~1 An m = m Am AN im APPENDIX 6 CON'T , PLATELET ADIIESIVENESS AND AGGPEGATION CODE 11 EXPOSURE TIt1E 1000 DAYS ADP 2X10 M COLLAGEN 0.26 tiG[ML ANIMAL 'I.ADNESIVENESS %ADNESIVEIIESS PRE EXPOSURE POST EXPOSURE PPE EXPOSIIPE PUST E~I'(t;iU.^.E tIUMDER _ PRE EXPOSURE POST EXPOSURE ('. AGGREGATION) (:_AGGREGATION) (: AGGREGAfION) (7. AGGP,FGA(IOII) 5052 56 48 74 74 69 66 5129 56 56 68 68 70 72 5148 49 45 62 68 72 6!t 5153 41 40 64 68 70 78 5165 66 65 74 70 72 76 5233 72 72 70 72 70 7A 5237 61 59 70 80 70 7?i 5267 71 73 70 74 76 70 t1EAN 59.0 57.3 69.0 71.8 71.1 72.3 8D 10.7 12.3 4.3 4.2 2.2 5.3 N 8 8 8 8 8 8 1 4 zlll>i.QYVC3
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ANIMAL r Ajll MM_w APPENDIX 6 CON'T PLATELET ADHESIVEfIESS AND AGGREGATION CODE I1 EXPOSURE TIME 1200 DAYS ADP 2X10 M iADHESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE HUf10ER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (: AGGREGATION) 5052 42 5129 53 5148 39 5153 31 5165 67 5233 60 5237 55 5267 61 MEAN 51.0 SD 12.4 N 8 COLLAGEN 0.26 CIC/ML PRE EY,P05U[?E COST FXI'USURE (y• AGG(tEGATION) ( : AG;I;EGATIOH) 45 49 53 HR NP. 49 44 43 HR IIP. 46 20 21 I;R IIR 3Ii 37 42 NR IIs' 37 12 18 44 NP. 63 12 30 48 58 54 14 22 48 113 60 18 2 1-1 46 53 48.5 25.8 31.6 44.5 43.0 10.2 15.2 12.8 1.9 5.0 8 8 8 4 3 t!ol[•UYQC3
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND_ AGGREGATION CODE 11 EXPOSURE TI1iE 1400 DAYS ADP 2XI0 11 COLLAGEN 0.26 Mr,/11L ANIMAL >ADNESIVENESS Y.ADNESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXI'QSU:iE NUMBER PRE EXPOSURE POST EXPOSURE ('/. AGGREGATION) ('/. AGGREGATION) (X AGGREGATION) (:: AGG.'.EGATI011) 5052 59 43 48 51 48 63 5 129 56 47 54 45 65 62 5148 71 70 12 28 20 26 5153 67 65 59 49 59 56 5165 69 67 48 44 60 52 5233 84 82 62 50 50 52 5237 61 60 52 44 42 38 MEAN 66.7 62.0 47.9 44.4 49. 1 49.9 SD 9.4 13.5 16.7 7.8 15.1 13.4 N 7 7 7 7 7 7 voIEotioe
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APPENDIX 6 CON!T PLATELET ADLIESIVENESS AND AGGREGATION CODE It EXPOSURE TIME 1500 DAYS ANIMAL XADHESIVENESS %ADHESIVENESS ADP 2X10 M PRE EXPOSURE POST EXPOSURE COLLAGEN 0.26 MG!tt;. PRE EXPOSURE POST EX1'OSURE NUMBER PRE EXPOSURE POST EXPOSURE ('/. AGGREGATION) (% AGGREGATION) (% AGGREGATIOM) (% AfGP,EGAfIOtI) 5052 61 58 , 48 38 40 44 5129 66 66 44 23 42 34 5148 45 55 20 19 36 36 5153 46 55 38 29 52 3C 5233 54 52 20 36 60 i0 5237 64 47 24 28 54 ?f 6 MEAN 56.0 55.5 32.3 29.7 47.5 41.0 SD 9.1 6.3 12_.5 6.8 9.4 6.5 N 6 6 6 6 6 6 v soyeovos
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..... ,.... rr wr wo. r..a anr ,aM im aY i AM 5 APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIME 200 DAYS ADP 2Xt0 M COLLAGEN 0.26 MG!ML ANIMAL )GADHESIVENESS X ADHESIVENESS PRE EXPOSURE - POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER _ PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (/ AGGREGATION) (l AGGREGATION) (: AGGREGATION) 5299 78 68 52 58 35 N.R. 5342 59 63 88 60 78 25 5344 68 65 74 68 84 78 5360 52 52 52 86 85 86 MEAN 64.3 62.0 66.5 68.0 70.5 63.0 SD 11.3 7.0 17.7 12.8 23.9 33.2 N 4 4 4 4 4 3 g01COVOR
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APPENDIX 6 CUN'T PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIME 400 DAYS ADP 2Xt0 M COLLAGEN Q.26.MG/ML ANIMAL XADHESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXP05URE NUMBER PRE EXPOSURE POST-EXPO§URE E7. AGGREGATION) (Y. AGGREGATION) E%C AGGREGATION) (2 AGGREGATION) 5042 74 79 78 75 70 70 5053 69 80 62 62 20 22 5085 77 71 65 80 80 72 5119 77 80 84 74 76 85 5151 79 86 34 30 20 78 5I75 67 70 80 82 74 75 5206 70 67 99 99 74 74 5228 79 69 58 76 56 82. 5299 87 86 68 68 92 86 5342 84 85 68 ' 74 75 76 5344 80 82 78 78 N.R. N.R. 5360 81 83 80 8U 76 80 MEAN 77.0 78.2 71.2 73.2 64.8 72.7 SO 6.1 7.0 16.2 16.2 23.7 17.6 H 12 12 12 12 11 11 'aJi€:0v08
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ADP 2X/0 M COLLAGEN 0.26 MG<ML XADHESIVENESS 'PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXP-OSURE POST"EXP05URE (: AGGREGATION) (: AGGREGATION) ('/. AGGREGATION) (X AGGRrGATION) 5042 75 76 70 62 55 44 5053 74 82 67 74 54 26 5085 77 77 74• 78 74 74 5119 87 88 68 68 38 38 5151 88 89 70 84 42 26 5228 86 91 N.R. N.R. N.R. N.R. 5299 69 78 76 64 N.R. N.R. 5342 69 83 68 80 72 80 5354 59 72 74 78 60 46 5360 53 77 72 76 72 66 MEAN 73.7 81.3 71.0 73.8 58.4 50.0 SD 11.7 6.4 3.2 7.5 13.8 21.0 N 10 10 9 9 8 8 1 y PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIME 600 DAYS Vlll[.l/VOt3
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIME 800 DAYS ADP 2XI0 M COLLAGEN 0.26'MG/ML ANIMAL %ADHESIVENESS Y.ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMOER PRE EXP05URE POST EXPOSURE f%: AGGREGATION) E% AGGREGATION) - ('/. AGGREGATTON) (% AGGREGATION) 5042 69 78 80 52 H.R. N.R. 5053 77 _ 71 62 . 72' N.R. N.R. 5119 74 81 74 74 68 66 5151 74 76 28 26 H.R. N.R. 5228 47 53 82 72 N.R. N.R. 5299 61 61 68 67 N.R. N.R. 5342 62 53 69 70 60 52 5344 52 59 72 76 28 38 MEAN 64.5 66.5 66.9 63.6 52.0 52.0 51) 10.9 11.4 1 7.0 16.9 21.2 14.0 N 8 8 _ 8 . 8 3 3 Gil lcD IroCJ
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APPENDIX 6 CON"T PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIfIE 1000 DAYS AUP- 22f 10 t1 COLLAGE7 0.26 6 t:Gi11L ' A11ItIAL 'f.ADHESIVENESS Y,ADIIESIVEHESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POSI EXFOSL'"E f NUt1DER PRE EXPOSURE POST EXPOSURE ('!. AGGREGATION) (Z AGCREGATION) (': AGGREGATIUI.1) (Z 1Gt,LLGAT1U11 I ) 5042 73 74 68 72 74 74 I 5053 68 70 64 68 70 72 5119 70 70 70 74 64 66 5151 80 82 36 26 80 S0 5228 63 69 74 76 72 72 5299 29 36 26 26 40 3 5342 37 40 30 16 44 IO 5344 33 35 25 25 38 27 C1EAN 56.6 59.5 49.1 47.9 60.3 50.5 5D 20.2 19,1 21:7 26.6 16.9 31.7 N 8 8 8 8 8 8 7 L aLTEOfirQR
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inn im iar amr m m n APPENDIX 6 CON'T PLATELET ADNESIVENESS AND AGG'EGATION CODE 32 EXPOSURE iIME 1200 DAYS ADP 2_X10 M COLLAGEN 0.26 F1G[f1L ANIMAL iADNESIVENESS XADIIESIVENEGS PRE EXPOSURE I'OST EXPOSURE PRE EXPO:iUE;E POST EXI'CSU2E NUt1DER _ PRE EXPOSURE POST EXPOSURE (Y. AGGREGATION) (: AGGP,EGATION) ('/. AGSP,EG.1T1011) (;: AGC.f'EGrITION) 5042 30 24 50 61 68 66 5053 27 26 50 32 70 63 5119 63 67 72 56 73 .G 5151 52 48 20 HR 50 60 5228 48 50 55 62 56 63 5299 51 57 58 48 55 5 0 5342 49 48 58 62 58 62 5344 61 58 24 40 60 49 MEAN 47.6 47.3 48.4 51.6 61.3 59.3 SD 13.0 15.1 17.7 11.9 8.2 8.0 11 8 8 8 7 8 8 LIif;OVOR
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 32 EXPOSURE TIHE 1400 DAYS ADP 2X10 II COLLAGEN 0.26 MGtrIL ANIMAL X_ADNESIVENESS 2ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EY.POSU"E P_oSf [xPO,Ur.E NUMOER PRE EXPOSURE POST EXPOSURE (i AGGREGATION) (: AGGREGATION) (: AGGF.EGATID11) (i AGGREGAiI0;1) 5042 76 69 45 38 62 52 5053 72 72 54 42 68 56 5i19 65 66 60 50 60 51 5151 68 66 16 NR 46 3:[ 5228 57 38 41 43 44 30 5299 58 52 50 45 54 47 5342 56 47 41 40 42 43 5344 52 44 31 24 47 39 MEAN 63.0 56.8 42.3 40.3 52.9 45.1 5D 8.5 13.0 13.8 8.1 9.6 9.6 N 8 8 8 7 8 Is I zil!T ll Yl/p
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, M ,AO A A ,l® A A A A A A APPENDIX 6 CON'T PLATELET ADIIESIVEa1EsS AND AGGREGATION CODE 32 EXPOSURE TIt1E_1500 DAYS ADP 2X10 M COLLAGEII 0.26 i1G/ML ANIMAL XADNESIVENESS 7ADNESIVENESS PRE EXPOSURE PDST EXPOSURE PRE EXPOSi1RE P05T [;fRSURE IIUIIDER PRE EXPOSURE POST EXPOSURE (X AGGREGAfION) (i AGGREGATION) (i AGGItEGATION) (2 AGGREGATI01U 5042 48 56 34 20 50 40 5053" 46 52 22 20 35 3? 5119 61 73 38 46 50 L5 5151 66 71 YO 22 32 42 5228 42 55 33 38 52 64 5299 56 56 37 42 50 52 53ti2 49 48 30 30 44 4 2 5344 50 48 28 33 35 40 MEAN 52.3 57.4 29.0 31.4 43.5 !i7 . 3 SD 8.1 9.6 9.2 10.2 8.2 11.2 N ~ 8 8 8 8 a a 4 clyr.ovoq
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in im jo jo ju Im m " m m i! M M i m APPENDIX 6 GON'T PLATELET ADHESIVENE.SS AND AGGREGATION CODE 60 EXPOSURE TIME 0 DAYS It ANIMAL XADHESIVENESS XADHESIVENESS ADP 2X10 M PRE EXPOSURE POST EXPOSURE COLLAGEN 0.26 MG/ML PRE EXPOSURE POST EXPOSURE NUMBER PRE EXP05URE POST EXPGSURE ('/. AGGREGATION) (Z AGGREGATION) ('/. AGGREGATION) (Z AGGREGATION) 5039 91 xxx 52 xxx 78 xax 5046 92 Nxx 90 xxx 78 ~ KR 5106 96 xxx 90 KkN 86 aaa 6014 91 >iKN 66 xxx 70 ~ a< 6038 82 xxx 30 xxx xxx aaa 6039 90 Kxw 48 xxx xxx r~~ MEAN 90.3 xXRK 62.7 xxxx 78.0 aKKa 5D 4.6 xxxx 24.1 Kxxx 6.5 xaxx H 6 -1 6 -1 4 -1 i
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"".NO mmmm .11im m mmmm m m m Jd i i APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 68 EXPOSURE TIME 100 DAYS ADP 2Xt0 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS XADHESIVENESS _ PRE EXPOSURE PDST EXPOSURE PRE EXPOSURE f'DST EXPOSURE __ _ _ NUMBER PRE EXPOSURE POST EXPOSURE ('. AGGREGATION) ('. AGGREGATION) (7 AGGREGATION) (% AGGREGATION) 5039 84 80 84 84 56 68 5046 80 80 80 72 73 75 6014 81 83 68 68 N.R. 43 MEAN 81.7 81.0 77.3 74.7 64.5 62.0 SD 2.1 1.7 8.3 8.3 12.0 16.8 N 3 3 3 3 2 3 qyIc0v08
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 68 EXPOSURE TIME 200 DAYS ADP 2X10 C COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS XADHESIVENESS PRE EXPOSURE P-OST EXPOSURE PRE EXPOSURE POST EXPOSURE HUMBER PRE EXPOSURE POST EXPOSURE ('f. AGGREGATION) ('._AGGREGATION) (X AGGREGATION) ('/. AGGREGATION) 5039 67 65 80 78 N.R. N.R. 5046 56 58 80 76 76 72 5106 55 53 58 82 66 62 5109 56 55 44 60 20 N.R. 6014 78 67 72 76 64 70 6018 30 47 80 78 64 H.R. 6038 51 55 72 74 N.R. N:R: 6039 75 55 74 78 N.R. N.R. MEAN 58.5 56.9 70.0 75.3 58.0 68.0 SD 15.2 6.5 12.8 6.6 21.8 5.3 N 8 8 8 8 5 3 9LiE0V0R
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A A A A A AA AMA A A A Aml/ MR a APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 68 EXPOSURE TIME 400 DAYS f ADP 2X10 M COLLAGEN 0.26 MGlML ANIMAL XADHESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXI'OSURE NUMBER PRE EXPOSURE POST EXPOSURE (: AGGREGATION) (Z AGGREGATION) (X AGGREGATION) (X AGGREGATION) 5039 71 51 80 98 38 14 5046 65 66 82 80 16 22 6014 64 62 84 ~ 82 11 40 6039 62 62 77 _ 88 N.R. H.R. 5106 46 53 68 68 76 H.R. 5109 52 52 70 76 64 72 6018 49 53 68 68 70 68 6038 50 55 66 68 66 66 MEAN 57.4 56.8 74.4 78.5 48.7 47.0 SD 9.2 5:7 7.2 10.8 26.9 25.3 N 8 8 8 8 7 6 I-11c0 vOR
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 68 EXPOSURE TIME 600 DAYS ADP 2X10 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS X_ADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE _POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (X AGGREGATION) (X AGGREGATION) ('/. AGGREGATION) E'!. AGGREGATION) 5039 43 41 44 31 62 49 5046 40 38 42 50 64 55 6014 31 38 64 40 68 50 6039 47 35 34 I1 64 34 5106 26 20 58 38 64 36 5109 36 32 65. 72 75 70 6018 34 24 62 58 64 64 6038 40 43 66 65 78 72 MEAN 37.1 33.9 54.4 45.6 67.4 53.8 SD 6.8 -8.1 12.5 19.8 5.9 14.4 N 8 8 8 8 8 8 4 RUMOg
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APPENDIX 6 CON'T. PLATELET ADHESIVENESS. AND AGGREGATION CODE 68-EXPOSURE TIME 800 DAYS ADP 2_X10 M COLLAGEN 0.26 MG/ML ANIMAL 3:ADNESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (% AGGREGATION) (X AGGREGATION) (% AGGREGATION) 5039 41 38 34 55 58 53 5046 44 44 60 62 60 64 6014 38 41 50 56 56 50 6039 44 42 63 48 63 62 5106 56 54 60 68 66 65 5109 62 67 60 56 67 62 60t8 52 54 63 68 65 56 6038 65 67 60 65 59 70 MEAN 50.3 50.9 56.3 59.8 61.8 60.3 SU 10.0 11.5 9.9 7.1 4.1 6.7 N 8 8 8 8 8 8 6IL(.OYQt3
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APPENDIX 6 CON'T PLATELET ADNESIVENESS AND AGGREGATION CODE 68 EXPOSURE TIME 1000 DAYS ADP 2X10 M COLLAGEN 0.26 MG<ML ANIMAL 7._ADHESIVENESS X ADNESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER _ PRE EXPOSURE POST EXPOSURE ('/, AGGREGATION) (% AGGREGATION) ('/, AGGREGATION) ('/. AGGREGATION) 5039 51 46 26 40 40 4 8 5046 40 11 34 13 40 16 5106 48 44 26 24 52 48 5109 64 54 40 38 46 50 6014 52 48 28 34 34 50 6018 55 54 50 50 55 55 6038 62 54 23 22 36 43 6039 48 35 16 10 48 24 MEAN 52.5 43.3 30.4 28.9 43.9 41.8 SD 7.8 14.6 10.7 13.9 7.6 14.0 N 8 8 8 8 8 8
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 68 EXPDSURE TIME 1100 DAYS ADP 2X10 M COLLAGEN 0.26 MG/ML ANIMAL %ADHESIVENESS YADHESIVENESS PRE EXPOSURE POST EXPDSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (i AGGREGATION) (: AGGREGATION) (% AGGREGATION) (r AGGREGAiIUN) 5039 50 53 16 14 40 38 5046 75 74 26 22 48 40 5 106 34 50 40 45 46 54 5109 57 59 40 34 48 46 6014 65 67 18 18 41 44 6018 44 47 28 38 40 44 6038 58 61 30 30 34 38 6039 55 52 22 10 42 39 MEAN 54.8 57.9 27.5 26.4 42.4 42.9 SD 12.5 9.2 9.1 12.3 4.8 5.4 N 8 8 8 8 8 8 F iSei[iQvol.7
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i ~.. ~.. .,.. A. V- A M M M R APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 0 DAYS ADP 2X10 M COLLAGEN 0.26 MGEML ANIMAL Y,ADH€3IVENESS 1:'ADHESIVEHESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE HUMBER 5054 _ PRE EXPOSURE POST EXPOSURE 90 xxk (: AGGREGATION) 88 (G AGGREGATION) xxx (y AGGREGATION) 84 (: AGGREGATION) xkx 5121 44 kHx 70 xxx xxx xkx 5 124 86 xxx 86 >Ex>< 70 xxx 5145 80 xxx 90 xxx 88 wxx 5157 75 xxx 78 xxx 78 xax 5171 68 wxw 88 mmx xxx x x x 5178 40 xxx 70' xxx wxr xRx 5185 8 t 8KK 64 ~ 8K>t 70 wK>: 5278 86 xxx 86 xxx 92 xax 6009 69 8Kk 20 Natat xlill Mlfif 6010 71 xxx 68 xxx 68 xxt 6011 71 KxX 55 SH8 xxa 6012 90 xxx 90 xxx 80 xxx 6020 86 xxx 84 xxx 80 X x x 6021 83 xxx 76 xxx 65 xa!x 6030 84 xxx 82 xxx 78 xxH 6031 82 xMx 76 Nxx 70 xx x 6035 83 xxx 80 xxx 80 xxx i ~ MEA11 76.1 xxxx 75.1 xxxx 77.2 ~ xxxx L] ~ 5D 14.2 xx~K 16.9 xxxk 8.1 xxNx N 18 -1 i8 -1 13 -1 5 6 Zr.IeQtrof3
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AM M M aa am AMA Wan a a S APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 100 DAYS ADP 2X10 M COLLAGEN 0.26 MG<ML ANIMAL yADHESIVENESS XADIIESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXP05URE POST EXPOSURE (% AGGREGATION) (X A GGREGATION) (: AGGREGATION) (Z AGGREGATION) 5054 74 88 38 32 72 78 5124 89 88 100 92 100 65 5155 84 88 50 42 82 N._R. 5157 77 79 96 100 92 92 5171 80 87 58 80 H.R. N.R: 5178 72 83 86 78 N:R. H.R. 5185 88 87 34. 30 76 48 5278 87 87 86 90 58 80 6009 75 83 78 82 N.R. 58 6010 82 88 72 72 76 58 6011 90 86 78 80 N.R. N.R. 6012 81 83 82 84 N.R. N.R. 6020 75 72 82 86 78 74 6021 70 69 54 58 80 N.R. 6030 86 79 74 62 N.R. H.R. 6031 78 77 62 64 N.R. N.R. 6035 85 91 86 88 N.R. N.R. i r MEAN 80.8 83.2 71.5 71.8 79.3 69.0 W 3D 6.3 _ 6.1 19.2 20.9 11.9 14.5 11 17 17 17 17 9 8 C-pl # =3 -a4i 4 t<~:: 1 ~ ~ ~ czyeotto&
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PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 200 DAYS ADP 2X10 M COLLAGEN 0.26 MGlML - ANIMAL XADIIESIVENESS XADIIESIVEHESS PRE EXPOSURE POST EXPOSURE PRE EXPO POST EXPDSURE SURE NUMBER PRE EXPOSURE POST EXPOSURE AGGREGATION) (y AGGREGATION) (Y. AGGREG ATION) ('/• AGGREGATION) 5124 71 72 82 84 62 64 5145 83 86 72 80 48 50 5157 62 69 72 . 70 68 66 5171 69 83 72 75 42 28 5178 75 64 80 100 H.R. N.R. 5185 68 78 80 82 50 24 6009 82 82 90 88 14 25 6010 80 82 72 •_ 85 45 40 6011 75 80 H.R. N.R. N.R. N.R. 6012 57 60 28 32 80 78 6020 71 71 76 82 52 N.R. 6021 74 77 94 92 60 30 6030 79 78 96 90 80 74 6031 77 84 90 86 68 20 6035 82 83 26 24 N.R. N.R. 5178 78 N.R. 82 N.R. H.R. N.R. 5278 81 N.R. H.R. N.R. H.R. H.R. ~ MEAN 74.9 76.6 74.1 76.4 55.8 45.4 W SD 8.3 7.8 20.8 21.8 18.3 21.8 ~ N 17 15 1§ 14 12 1T 1 DUCOVaR
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,,. m m m m m m m m m m m 0 m m m m a a APPENDIX 6 CON'T PLATELET ADNESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 400 DAYS ADP _2XI0 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS XADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER P-RE EXPOSURE POST EXPOSURE (% AGGREGATION) (`/. AGGREGATION) (2 AGGREGATION) ('/. AGGREGATION) 5054 53 65 70 72 66 62 5124 r 73 74 71. . 71 75 68 5158 N.R. N.R. 68 68 69 68 5157 41 55 68 80 N.R. N.R. 5171 68 80 N.R. N.R. N.R. H.R. 5185 79 60 65 64 54 32 6009 5/ 59 80 72 70 48 6010 54 57 70 72 50 _ N.R. 6011 47 58 56 8 20 16 6012 69 69 68 72 60 24 6020 65 75 70 75 N.R. N.R. 6021 51 56 72 78 64 76 6030 81 8f 76 78 N.R. N.R. 6031 60 44 60 67 N.R. 11.R. 6035 69 71 73 73 N.R. N.R. i MEAN 61.5 64.6 68.4 67.9 58.7 49.3 .~ 5D 12.3 10.8 8.0 . 17.8 16.5 22.8 ~ 0 N 14 14 14 14 9 8 1 F~"1 ~ r
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A A A M M M iM = aM at sM M m m aa a, APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 600 DAYS ADP 2X10 M COLLAGEN 0.26 MG/ML ANIMAL XADHESIVENESS YADHESIVENESS PRE EXPOSURE POST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (/ AGGREGATION) (% AGGREGATION) (Z AGGREGATION) ('/. AGGREGATION) 5054 71 66 82 70 80 78 5154 60 59 65 62 72 68 6031 48 53 82 76 79 79 6030 63 56 66 72 74 70 5171 51 47 72 • 60 64 72 6009 46 49 80 72 66 64 6010 47 46 68 70 64 68 6011 46 48 58 46 66 74 5124 57 52 66 63 74 68 5157 44 41 45 68 48 62 6012 47 44 66 68 68 72 6020 49 45 68 60 72 72 6035 56 55 50 40 78 70 MEAN 52.7 50.8 66.8 63.6 69.6 70.5 5b 8.1 6.9 11.2 10.5 8.5 4.8 N 13 , 13 13 13 13 13 C.75 ~ 4 t^'7 ~ ~ 9zleovos
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 800 DAYS ADP 2X10 M ANIMAL Y.ADHESIVENESS X_ADHESIVENESS PRE EXPOSURE POST EXPOSURE NUMOER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (7. AGGREGATION) 5028 60 45 50 30 5054 62 61 20 10 5124 54 59 50 56 5145 61 51 29 30 5157 45 45 32 58 5171 33 59 62 76 6009 44 54 33 30 6010 54 48 63 72 6011 39 45 17 10 6012 5!i 52 39 42 6020 58 56 65 56 6030 51 50 20 18 6031 54 53 26 22 6035 53 55 29 60 MEAN 51.6 52.4 38.2 40.7 SD 8.5 5.4 16.8 22.3 .~ N 14 14 14 14 ~ N COLLAGEN 0.26 MG/ML PRE EXPOSURE (X AGGREGATION) MR 14 66 10 53 MR MR NR MR POST EXPOSURE (% AGGREGATION) MR 24 67 MR 60 MR MR MR HR 58 56 62 68 39 57 39 56 57 65 44.1 56.6 20.5 14.1 9 8 T"IUOVoR
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APPENDIX 6 CON'T PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 1000 DAYS ANIMAL %ADHESIVENESS XADHESIVENESS ADP 2X10 M PRE EXPOSURE POST EXPOSURE COLLAGEN 0.26 MG/ML PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (: AGGREGATION) (i AGGREGATION) (X AGGREGATION) (r AGGREGATION) 5028 71 61 46 50 62 60 5054 59 58 52 49 52 48 5145 56 60 48 54 50 40 5171 70 56 40 43 55 54 6009 58 40 48 30 64 52 6010 73 71 64 48 66 50 6011 62 73 23 13 20 10 6012 82 74 33 45 46 50 6020 63 50 63 57 55 48 6030 51 50 38 52 34 26 6031 57 54 44 54 44 44 6035 80 74 46 40 66 58 MEAN 65.2 60.1 45.4 44.6 51.2 45.0 SD 9.9 11:0 11.5 12.4 13.8 14.2 I N 12 12 12 12 12 12 w r RZA I coVoR
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.X.,ar jm ir in at ar ,r sir m m M m a M J!! ~~ APPENDIX 6 60N1T , PLATELET ADHESIVENESS AND AGGREGATION CODE 67 EXPOSURE TIME 1100 DAYS ADP 2X10 M COLLAGEN 0.26 MGiML ANIMAL 7.ADHESIVENESS $ADHE5IVENESS PRE EXPOSURE YOST EXPOSURE PRE EXPOSURE POST EXPOSURE NUMBER PRE EXPOSURE POST EXPOSURE (% AGGREGATION) (Y. AGGREGATION) (: AGGREGATION) (2 AGGREGATION) 5028 55 60 42 36 64 52 5054 58 62 42 34 49 43 5124 68 59 40 46 58 60 5145 69 61 34 40 60 57 5171 52 59 52 40 60 50 6009 51 54 50 46 62 50 6010 46 49 62 45 64 46 6011 46 49 18 24 50 32 6020 67 77 38 38 50 53 6030 58 59 25 22 57 46 6031 57 61 34 26 58 67 6035 60 67 22 28 53 50 MEAN 57.3 59.8 38.3 35.3 57.1 50.5~ Sil 7.9 7.5 12.8 8.5 5.4 8.8 N 12 12 12 12 12 12 11r szleovob~
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- .... ,...0 mr r~r .f.. .w.. r..r wOr rrt9 am im AM m m w DOG ALBUMIH ALPHA I HD. (G/DL) (G/DL) APPENDIX 7 CON'T SERUM PROTEIH ELE6TROPHORESIS CODE 68 EXPDSURE TIME 0 DAYS ALPHA 2 BETA GAMMA (G/DL) (G1DL) (G/DL) TOTAL AiG GLOBULIH RATIO (GIDL) 5039 3.75 0.26- 1.37 1.33 0.49 3.45 1.09 5046 2.97 0.22 1.01 2.03 0.76 4.03 0.74 5106 3.02 0.17 1.03 1.31 0.57 3.08 0.98 5109 3.07 0.24 1.09 1.10 0.57 3.03 1.01 5143 3.19 0.31 1.07 1.66 0.57 3.61 0.88 6014 3.12 0.18 1.06 1.24 0.51 2.88 1.08 6038 3.59 0.13 0.92 1.25 0.42 2.71 1.32 6039 2.83 0.30 1.14 1.49 0.45 3.37 0.84 MEAN 3.19 0.23 1.09 1.43 0.53 3.27 0.99 5D 0.32 0.06 0.13 0.30 0.11 0.43 0.18 H 8 8 8 8 8 8 8 I ~ rn fq!r(.Oi/O(3
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J.r Ar aIr im .im in ,r" a n ~ APPENDIX 7 CON'T SERUM PROTEIN ELECTROPNORESIS CODE 68 EXPOSURE TIME 100 DAYS DOG ALBUMIN ALPHA I ALPHA 2 BETA GAMMA TOTAL GLOBULIN A:G RATIO (10. (G!DL) • (G/DL) (GiDL) (G/DL) (G/DL) (G/DL) 5039 3.90 0.21 1.06 1.29 0.51 3.08 1.27 5046 3.60 0.23 0.99 1:62 0.65 3.48 1.03 5143 3.40 0.17 0.95 1.70 0.56 3.38 1.01 6014 4.00 0.17 0.89 1.27 0.37 2.70 1.48 6016 3.90 xxxx xxxx xxxx xKKx xxxK x_xxwm 6039 3.80 0.16 1,11 1.72 0.68 3.67 1.04 MEAN 3.77 0.19 1.00 1.52 0.55 3.26 1.16 SD 0.23 0.03 0.09 0.22 0.12 0.38 0.21 N 6 5 5 5 5 5 5 I Z3ICUV\IR
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APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 68 EXPOSURE TIME 200 DAYS DOG ALBUMIN .ALPHA 1 ALPHA 2 BETA GAMMA TOTAL GLOBULIN A~G RATIO f10. (G/DL) (G/DL) (GtDL) (G/DL) (G/DL) (G/DL) 5039 4.00 0.19 1.15 1.19 0.42 2.95 1.36 5046 3.40 0.22 1.18 1.61 0.61 3.62 0.94 5143 3.00 0.25 1.25 2.04 0.68 4.21 0.71 6014 4.10 0.29 1.04 1.18 0.41 2.93 1.40 6016 3.10 0.23 1.41 1.77 0.49 3.89 0.80 6038 3.43 0.11 0.78 . 1.49 0.50 2.87 1.20 6039 3.70 0.18 1.16 1.48 0.47 3.28 1.13 MEAH 3.53 0.21 1.14 1.54 0.51 3.39 1.08 §D 0.42 0;06 0.19 0.31 0.10 0.53 0.27 11 7 7 7 7 7 7 7 c9lE0v(l~3
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imr arr am am im APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 68 EXPOSURE TIME 400 DAYS DOG NO. ALBUMIN (G/DL) ALPNA I (G/DL) ALPHA 2 (G/DL) BETA (G/DL) GAMMA (G/DL) TOTAL GLOBULIN (G/DL) A:G RATIO 5106 3.28 0.14 1.27 1.36 0.52 3.29 1.00 5109 3.11 0.19 1.18 1.71 0.78 3.86 0.81 6018 3.34 0.16 0.90 1.52 0.76 3.34 1.00 6038 3.21 0.19 0.97 1.71 0.58 3.45 0.93 MEAN 3.23 0,17 1.08 1.57 0.66 3.48 0.93 SD 0.10 0.02 0.17 0.17 0.13 0.26 0.09 N 4 - 4 4 S 4 4 4 . vgtcovoR
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..~> ^-o.F!.a:i'+w ,,•o,;,.r18!M. ..-,,A•1';~, APPENDIX,7' CON'T', SERUM PROTEIN ELECTROPNORESIS CODE 68 EXPOSURE TIME 600 DAYS DOG H0. ALBUMIN (G/DL) ALPHA I (GiDL) ALPHA 2 (G/DL) BETA (G/DL) GAMMA (GtDL) TOTAL GLOBULIN (GtDL) A:G RATIO 6014 3.16 0.27 0.60 1.48_ 0.66 3.01 1.05 5039 3.48 0.39 0.71 1:56 ` 0.43 3.09 1.13 5046 3.49 0.38 0.60 1.70 0.71 3.39 1.03 5143 3.39 0.25 0.66 1.66 1.12 3.69 0.92 6016 2.89 0.25 0.42_ 1.71 1.00 3.38 0.86 6039 3. 11 0.48 0.61 1.70 0.68 3.47 0.90 5106 3.23 0.21 1.22 1.38 0.63 3.44 0.94 5109 3.56 0.10 1.04 1.43 0.85 3.42 1.04 6018 3.53 0.10 0.98 1.45 0.92 3.45 1.02 6038 3.41 0:16 1.04 1.59 0.77 3.56 0.96 MEAN 3.32 0.26 0.79 1.57 0.78 3.39 0.98 SD 0.22 0.13 0.26 0.12 0.20 0.20 0.08 H 10 10 10 10 10 10 10 N Q r "`r{ lr~
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APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 68 EXPOSURE TIME 800 DAYS DOG N0. ALBUMIN (GIDL) ALPHA I (G/DL) ALP-HA 2 (G/DL) BETA (G/DL) GAMMA (G/DL) TOTAL GLOBULIN (GiDL) A:G RATIO 5039 3.38 0.24 1.44 1.30 0.62 3.60 0.94 5046 3.00 0.21 1.05 1.29 0.73 3.28 0.91 5106 4.62 0.28 1.61 1.65 0.72 4.26 1.08 5109 3.81 0.25 1:35 1.68 0.98 4.26 0.89 5143 3.28 0.19 1.38 1.62 0.79 3.98 0.82 6014 3.39 0.17 1.13 1.24 0.45 2.99 1.13 6016 3.36 0.53 0.95 1:31 0.54 3.33 1.01 6018 3.68 0.28 1.45 1.94 1.13 4.80 0.77 6038 3.02 0.26 1.31 1.75 0.84 4.16 0.73 6039 3.06 0.68 0.87 1.65 0.82 4.02 0.76 MEAN 3.46 0.31 1.25 1.54 0.76 3.87 0.91 SD 0.49 0.16 0.24 0.24 0.20 0.56 0.14 N 10 10 10 10 10 10 10 ' •' !'.liV vL/N
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...., ,mp.r -k=. ~.ac, Wm= APPENDIX 7 C9N'T 4w ann ae >>m SERUM PROTEIN ELECTROPIIORESIS CODE 68 EXPOSURE TIME 1000 DAYS I DOG NO. ALBUMIN (G/DL) ALPHA I (G/DL) ALPHA 2 (G/DL) BETA (G/DL) GAMMA (G/DL) TOTAL GLOBULIN (G/DL) A:G RATIO 5039 3.68 0.20 1.28 1.23 0.49 3.20 1.15 5046 3.65 0.25 1.26 1.58 0.64 3.73 0.98 5106 3.29 0.17 1.02 1.02 1.08 3.29 1.00 5109 3.51 0.11 1.15 1.15 1.15 3.56 0.99 5143 3.74 0.15 1.25 1,83 0.79 4.02 0.93 6014 3.67 0.21 1.31 1.32 0.46 3.30 1.11 6016 3.51 0.48 1:16 1.60 0.64 3.88 0.90 6018 4.61 0.08 .1.07 0.97 0.85 2.97 1.55 6038 3.63 0.08 1.02 1,24 0.81 3.15 1.15 6039 3.38 0.57 0.9(i 1.4 5 0.64 3.60 0.94 MEAN 3.67 0.23 1.15 1.34 0.75 3.47 1.07 SD 0.36 0. 17 0.13 0.27 0.23 0._34 0.19 N 10 10 10 10 10 10 10 w N 1 ~ F~`1 ~rW -~d
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7-$ mmmmm Amm MAMMA MR U-S APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 68 EXPOSURE TIME 1100 DAYS TOTAL A:G DOG ALBUMIN ALPHA I ALPHA 2 BETA GAMMA GLOBULIN_ RATIO N0. (G%DL) (G/DL) (G/DL) (G_/DL) (G/DL) (GiDL) 5039 3.65 0.37 1.29 1.17 0.79 3.62 1 .01 5046 3.83 0.19 0.98 1.46 0.71 3.34 1.15 5106 2.77 0.60 1.03 1.60 0:77 4.00 0.69 5109 2.97 0.58 0.84 1.47 0.91 3.80 0.78 5143 3.42 0.19 1.22 2.10 0.84 4.35 0.79 6014 4,39 0.25 1.06 1.41 0.47 3.19 1.38 6016 3.44 0.28 1:28 2.01 0.87 4.44 0.77 6018 3.20 0.38 0.91 1.64 0.95 3.88 0.82 6038 3.21 0.43 0.91 1.39 0.64 3.37 0.95 6039 3.38 0.32 1.09 1.23 0.85 3.49 0.97 MEAN 3.43 0.36 1.06 1.55 0.78 3.75 0.93 SD 0.46 0.15 0.16 0.30 0.14 0.43 0.21 N 10 10 10 10 10 10 10 ; R=91COtiOe
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At" Am JOL APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 67 EXPOSURE-TIME 100 DAYS TOTAL A:G DOG ALBUMIN A_LPNA I ALPHA 2 BETA GAMMA GLOBULIN RATIO N0. (GtUL) (G/DL) (G/DL) (G/DL) (G/DL) (GiDL) 6031 3.70 0.23 0.88 .1.37 0.54 3.02 1.23 6032 4.00 0.16 1.03 1.25 0.57 3.01 1.33 6034 3.90 0.18 1.00 1.30 0.48 2.97 1.31 6035 4.50 0.23 1.14 1.35 0.44 3.15 1.43 6037 3.60 0,18 0.94 1.30 0.51 2.93 1.23 6040 3.80 0.14 0.93 ,1,28 0.46 2.80 1.36 MEAN 3.71 0.20 1.02 1.38 0.51 3.12 1.21 SO 0.33 0.05 0.15 0.19 0.12 0.33 0.20 _ N 54 54 54 54 54 54 54 2,':,Tcovw3
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AM Arr AN JW i APPENDIX 7 CON'T SERUM PROTEIN ELECTROPHORESIS CODE 67 EXPOSURE TIME 200 DAYS DOG N0. ALBUMIN (G/DL) ALPNA I (G/DL) ALPNA 2 (G/DL) ' BETA (G/DL) GAMMA (G/DL) TOTAL GLOBULIN (G/DL) A:G RATIO 6028 3.10 0.23 1.12 1.23 0.40 2.97 1.04 6030 4.00 0.17 1.03 1.17 0.47 2.84 1.41 6031 3.30 0.24 0.88 1.46 0.57 3.15 1.05 6032 3.50 0.10 0.79 1.19 0.67 2.75 1.27 6034 3.20 0.17 1.06 1.25 0.53 3.01 1.06 6035 2.70 0.10 0.76 1.22 0.29 2.37 1.14 6037 2.80 0.17 0.91 1.59 0.74 3.41 0.82 6040 3.10 0.17 0.99 1.40 0.65 3.22 0.96 MEAN 3.35 0.19 1.02 1.36 0.55 3.17 1.08 SD 0.32 0.05 0.16 0.18 0.14 0.55 0.18 N 56 56 56 56 56 56 56 1 4 - MIi.QYOC7
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A~ A~ an. t!= d== .2=2 .- J ..1_.j ..eIL .IM im im An An A1 An APPENDIX 8 CON'T CLINICAL CHEMISTRY CODE 68 EXPOSURE TIME 0 DAYS DOG NO. BUN (MGiDL) GLUCOSE (MG/DL) CREATININE (MG /DL)- CHOLESTEROL (MGiDL) CALCIUM (MG/DL) PHOSPHORUS (MGiDL) SGOT (MU/ML) SGPT (R1UlML) TOTAL PROTEIN (G/DL) 5039 11.6 t15.0 _ 0.8 141.5 11.1 4.1 18.6 21.0 7.20 5046 15.5 116.0 0.8 NNNNN 9.5 3.5 20.4 27.0 7.00 5106 12.3 95.0 0.8 212.0 11.2 3.6 13.5 22.0 6.10 5109 20.5 97.5 1.1 183.0 10.5 4.2 21.0 83.0 6.10 5143 15.0 113.5 0.9 222.0 10.1 ' 3.8 15.4 27.0 6.80 6014 13.5 115.0 0.6 145.0 10.8 4.3 27.0 15.0 6.00 6038 13.0 110.0 1.0 153.0 11.1 5.1 22.5 31.5 6.30 6039 13.4 105.0 0.9 182.0 11.6 3.6 22.5 36.0 6.20 MEAN 14.35 108.38 0.86 176.93 10.74 4.02 20.11 32.81 6.46 3D 2.80 8.31 0.15 32.07 0.68 0.53 4.27 21.29 0.47 _ N 8 8 8 7 8 8 8 8 8 TTL(..OYlJC3
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.,E .,E, - jr.i ~w m im JE M Jr A , APPENDIX 8 CON'T ELINICAL CHEMISTRY CODE 68 EXPOSURE TIME 100 DAYS DOG BUN GLUCOSE REATININE C CHOLESTEROL CALCIUM PHOSPHORUS SGOT SOPT TOTAL PROTEIN N0. (M__G/DL) (MG/DL) _ (MG/DL) (MG/DL) (MGEDL) (MG/DL) (MU/ML) (MU[ ML) (GiDL) 5039 22.0 1_03.0 0,7 170.0 10.7 _ 4.2 15.0 _ 41.0 6.70 5046 33.0 98.0 0.5 202.5 10.4 5.2 21.0 57.0 6.80 5143 26.0 95.0 0.6 225.0 10.0 5.5 21.0 47.0 6.80 6014 21.0 118.0 0.6 -(65.0 10.1 3.3 26:0 40.0 6 .60 6016 25.0 111.0 NwMr 140.0 10.2 4.6 15.0 63.0 N?(MkN 6039 21.0 113.0 0.6 182,6 10.4 5.0 17.0 42.0 7.10 MEAN 24.67 106.33 0.60 189.18 10.20 4.63 19.17 48.33 6.80 50 4.59 9.07 0.07 22.17 0.17 0.80 4.31 9.54 0.19 N 6 6 5 6 6 6 6 6 5 p ZizcOvQR
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APPENDIX 8 CON'T CLINICAL CHEMISTRY CODE 68 EXPOSURE TIME 200 DAYS DOG N0. BUN (MG/UL) GLUCOSE (MG/DL) CREATININE (MG%DL) CHOLESTEROL (MG/DL) CALCIUM (MG/DL) PHOSPHORUS (MGlUL) SGOT (MU/ML) SGPT (MUlML) TOTAL PROTEIN (G/UL) 5039 15.0 110.0 1.5 155.0 9.6 3.7 21.0 45.0 6.60 5046 15.0 117.0 1.5 160.0 9.3 3.2 30.0 33.0 6.95 5143 19.0 100.0 1.4 200.0 10.2 4.1 27.0 55.5 8.20 6014 13.0 124.0 1.4 150.0 9.8 3.0 41.0 43.0 7.00 6016 23.0 85.0 1.5 162.5 9.9 4.3 24.0 63.0 7.90 6038 18.0 i14.0 1.0 130.0 10.0 3.3 24.0 33.0 6.30 6039 13.0 125.0 0.4 165.0 9.6 3.7 18.0 48.0 7.10 MEAN 16.57 109.29 1.24 160.36 9.77 3.61 26.43 45.79 7.15 3U 3.64 14.30 0.41 21.04 0.30 0.48 7.50 11:04 0.68 N 7 7 7 7 7 7 7 7 7 C-D ~ ca,! 4 C= ~ ~ zr- CLZCOVOS
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~ JK m m m m m APPENDIX 8 CON'T CLINICAL CNEMISTRY CODE 68 EXPOSURE TIME 400 DAYS DOG NO. BUN (MG/DL) GLUCOSE (MGfDL) CR_EATININE (t7G<DL) CHOLESTEROL (MG/DL) . CALCIUM (MG<DL) PHO§P-IIORUS (MG/DL) SGOT (MU/ML) SGPT (MU/ML) TOTAL PROTEIN (G/DL) 5106 9.0 96.0 0.8 205.0 8.7 3.0 20.0 36.0 6.60 5109 13.0 96.0 0.9 (70.0 8.4 3.3 34.0 51.0 7.00 6018 15.0 100.0 0.8 161.0 8.9 4.0 22.0 60.0 6.70 6038 13.0 112.0 0.9 155.0 9.0 3.2 48.0 66.0 6.70 MEAN 12.50 101.00 . 0.85 174.25 8.75 3.38 31.00 53.25 6.75 5D 2.52 7.57 0.06 21.50 0.26 0.43 12.91 13.05 0.17 N 4 4 4 4 4 4 4 4 4 • TUQYOC3
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APPENDIX 8 CON'T CLINICAL CHEMISTRY CODE 68 EXPOSURE TIME 600 DAYS DOG H0. BUN (MG/DL) GLUCOSE (MG/DL) CREATININE (MG/DL) CHOLESTEROL (MG/DL) CALCIUM (MG/DL) PIIQSP_HORUS (MG/DL) SGOT (MU/ML) SGPT (MUiML) TOTAL PROIEIN (G/OL) 6014 15.0 Y16.0 0.8 150.0 8.8 3.3 28.0 36.0 6.20 5039 15.0 132.0 0.7 165.0 9.2 3.1 18.0 45.0 6.60 5046 12.0 100.0 0.7 175.0 9.4 3.9 26.0 48.0 6.90 5143 18.0 116.0 1.0 225.0 9.1 3.6 26.0 66.0 7.10 6016 15.0 112.0 1.0 180.0 9.2 4.0 18.0 57.0 6.30 6039 14.0 112.0 0.7 160.0 9.6 4.3 18.0 60.0 6.60 5106 15.0 96.0 0.8 215.0 8.7 3.0 18.0 36.0 6.70 5109 t 5.0 112.0 0.9 185.0 8.4 3.3 26.0 72.0 7.00 6018 _ 9.0 124.0 0.8 220.0 8.9 4.0 16.0 135.0 7.00 6038 18.0 128.0 1.0 170.0 9.0 3.2 26.0 63.0 7.00 M€AN 14.60 114.80 0.84 184.50 9.03 3.57 22.00 61.80 6.74 50 2.63 11:32 0.13 26.50 0.35 0.45 4:71 28.50 0.31 N 10 10 10 10 10 t0 10 10 10 L ~;IzeoVoe
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JI~-•~J~ioo~oC~o~O~O..COO'. 1f1Op~.O ~~\.......... ..~,, IL J O:.O~O~OiO.C O O O O: O^~~O NI ~i~~i 6~1~' ~:.v;~i~ 1~ ~ I ~ RL JO:O'.O~OOO.OGOO: r.~', . . . OT~O O^^ III I Nv'...^ .... J1 nw I 2\Nw.t~in~itlw~.t.tw~w~. d c7 2 IL1~t, O~ ~T o w i 6. N } ~ ¢ G O S ^ _~ Cp. CO.OM~NN.t~a0w111~ O~P~oi (J C~ C.7\.OP~^^000~"00 F• W J c ^ ^-.-.- ^ -.^ - . O~O ~ N£' W 2 W ¢E U y+ ^ ~ Ci Ot JU1 W d cl- ¢ aO C'J 1 .._ x = W J' O W J.O 0~~~.G O.O O~O O O~O OC.O'. J00. tRYi\OO.OM~IA1[1~U10~0~0 f.)•O. W LLlIU'.•me~f~NLO.N~x~.On.w'.C J~^-NI~N'~^^^ O .. ~ , C O t7 LU H J M \.. . p^^.. ¢ ~ e o W .e G N~J O.O O.O O~O O O O~O (J~.\~O:OO~.ulOtno~nOllY, O~~.- o. ~ ~~C~~NNM~^^MNNM~^ N.h~ J~^^ ^^..~-^^^^ N, (~ v ^ J O~o O~.O O~~O O.O~O.O~ Z C • O N O o m ^ E J
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APPENDIX 8 CON'T CLINICAL CHEMISTRY CODE 68 EXPOSURE TIME 1000 DAYS DOG NO. BUN (MG/DL) GLUCOSE (MG%DL) CREATININE (MGiDL) CHOLESTEROL (MG/DL) CALCIUM (MG/DL) PHOSPHORUS (MG/DL) SGOT (MUlML) SGPT (MUiML) TOTAL PROTETt+ (GIDL) 5039 20.0 11§.0 0.7 160.0 11.4 6.6 40.0 50.0 6.90 5046 28.0 115.0 0.7 170.0 10.8 5.9 48.0 48.0 7.50 5106 14.0 110.0 1.0 170.0 9.6 3.6 21:0 39.0 6.60 5109 23.0 105.0 1.0 160.0 9.4 4.5 40.0 330.0 7.10 51(i3 20.0 120.0 0.8 220.0 11.0 5.7 28.0 46.0 7.80 6014 15.0 135.0 0.8 185.0 10.6 5.2 36.0 52.0 7.00 6016 26.0 110.0 0.9 205.0 11.4 5.2 78.0 73.0 7.40 6018 22.0 120.0 1.0 170.0 9.6 4.2 25.0 50.0 7.60 6038 24.0 130.0 1.0 145.0 9.0 4.4 25.0 40.0 6.80 6039 18.0 130.0 0.7 165.0 11.2 5.3 26.0 54 .0 7.00 MEAN 21.00 11_9.00 0.86 175.00 10.40 5.06 36.70 78.20 7.16 SD 4.52 9.94 0.13 22.48 0.91 0.89 16.89 88.97 0.38 N 10 10 10 - 10 - 10 10 10 10 - 10 3 P p +1-MOVOR
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APPENDIX 8 CON'T . CLINICAL CHEMISTRY CODE 68 EXPOSURE TIME 1100 DAYS DOG BUN GLUCOSE CREATININE CHOLESTEROL CALCIUM PHOSPHORUS SGOT SGPT TOTAL PROTEIN NO. (MG/DL) (MG/DL) (MG/DL) (MG/DL) (MG%D_L) (MG/DL) (MU/ML) (MUi1lL) (G/DL) 5039 28.0 120.0 1.3 200.0 12.2 5.1 31.0 50.0 7.30 5046 16.0 115.0 1.0 150.0 11.8 5.2 43.0 45.0 7.20 5106 14.0 105.0 0.9 170.0 9.4 3.6 20.0 42.0 6.80 5109 19.0 120.0 1.0 130.0 9.0 3.9 35.0 48.0 6.80 5143 25.0 145.0 1.0 220.0 9.6 4.8 27.0 53.0 7.80 6014 26.0 130.0 1.0 170.0 11.2 5.0 47.0 54.0 7.60 6016 20.0 120.0 1.1 175.0 8.8 3.5 29.0 64.0 7.90 6010 22.0 130.0 1.0 150.0 9.0 3.1 22.0 52.0 7.10 6038 26.0 110.0 0.9 100.0 9.6 4.1 33.0 46.0 6.60 6039 24.0 120.0 1.0 140.0 8.8 4.1 23.0 50.0 6.90 MEAN 22.00 121.50 1.02 160.50 9.94 4.24 31.00 50.40 7.20 5D 4.64 11.32 0.11 34.52 1.29 0.74 8.86 6.08 0.45 N 10 10 10 10 10 10 10 10 10 4 61zcovoR
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(COHTINUEO) APPENDIX 8 CON'T CLINICAL CHEMISTRY I CODE 67 EXPOSURE TIME 100 DAYS DOG BUN GLUCOSE , CREATININE CHOLESTEROL CALCIUM PHOSPHORUS SGOT SGPT TOTAL P-ROtEIN N0. (MGtUL) (MG/DL) (MG/DL) (MGiDL) (MG/DL) (MG/DL) (MUiML) (MUiML) (G_iDL) 6023 32.0 90.0 0.8 175.0 . 9.8 3.9 31.8 42.0 6.60 6024 28.0 90.0 0.8 182.5 10.5 5.1 30.3 47.0 6.75 6026 18.0 93.0 0.7 140.0 10.4 3.9 34.5 33.0 6.45 6027 21.0 93.0 0.7 135.0 10.1 5.1 35.1 48.0 6.40 6028 21.0 1Q0.0 0.6 185.0 10.5 5.0 27.0 50.0 6.43 6030 1 8:0 97.0 0.7 147.5 9.6 4.0 _ 32.1 20.0 5.70 6031 19.0 98.0 0.7 145.0 10.2 3.6 37.5 30.0 6.38 6032 8:0 103.0 0.6 190.0 9.9 3.4 34.5 24.0 6.00 6034 10.0 120.0 0.5 155.0 10.1 4.8 33.0 74.0 6.16 6035 19.0 105.0 0.7 180.0 10.4 4.3 33.0 51.0 6.80 6037 17.0 103.0 0.6 178.0 10.1 5.5 34.5 50.0 6.25 6040 13.0 135.0 0.7 152.5 10.1 3.0 38.1 39.0 6.25 MEAN 16.90E- 100.19 0.66 165.108- 10.018 4.16 32.303+ 45.77 6.430- 5D 6.44 13.95 0.09 27.65 0.32 0.67 6.08 19.02 0.29 N 54 54 54 54 54 54 54 54 54
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- -- ~~ A i A A (CONTINUED) APPENDIX 8 CON'T CLINICAL CHEMISTRY CODE 67 EXPOSURE TIME 200 DAYS DOG BUN GLUCOSE CREATININE CHOLESTEROL CALCIUM PHOSPHORUS 560T SGPT TOTAL PROTEIN N0. (MG/DL) (MGtDI) (MG/DL) (MG/DL) (MG/DL) (MG/DL) (MU/ML) (MUiML) (GlUL) 6020 18.0 105.0 1.3 112.5 9.3 3.2 14.0 70 .0 6.90 6021 14.0 115.0 0.6 157.5 9.8 4.1 27.0 74.0 6.50 6023 26.0 76.0 0.7 149.5 9.6 4.7 33.0 82.0 6.05 6024 24.0 87.0 0:7 182.5 9.8 5.1 29.0 60.0 7.00 6026 16.0 96.0 0.8 140.0 10.0 4.5 29.0 74.0 6.30 6027 22.0 98.0 0.7 122.5 9.9 5.4 24.0 71,0 6.10 6028 kxxx 88.0 0.6 155.0 9.8 4.1 atxNy)( 57.0 6.10 6030 15.0 88.0 0.7 157.5 9.8 4.2 23.0 27.0 6.50 6031 19.0 103.0 0.8 135:0 9.9 3.8 33.0 41.0 6.30 6032 17.0 98.0 0.8 125,0 9.2 4.5 27.0 26.0 6.10 6034 12.0 100.0 1:3 125.0 9.8 4.2 21.0 69.0 6.30 6035 12.0 90.0 0.6 122.5 8.9 2.7 11.0 38.0 5.45 6037 15.0 90.0 0.9 152.5 9.5 4.4 25.0 39.0 7.05 6040 20.0 90.0 0.9 135.0 9.8 5.3 18.0 33.0 6.85 MEAN 17.44 96.10 0.843- 148.06 9.86 4.308f 28.31 55.97 6.44a' 5D 4.43 11.83 0.29 23.25 • 0.54 0.80 10.63 15.82 0.50 N 52 53 56 53 53 53 52 53 56 4 VVlzUY~vVV
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m A !! A m n n n n E r APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 0 DAYS EXPOSURE -Kw DUG -------------ARTERIAL BLOOD GASES-------------- 02HB 118 COIIB PH PC02 P02 N2 WASIIOUT VOL. T0 2'/. N2 CLOSING ----VOLUME---- VITAL CAPACITY PHASE III SLOPE MINUTE VOLUME N0. (!) (Q</00 ML) (Y) (MM NG) (MM /10) (ML) •(ML) (/) (ML/KG) ('/. N2!L) (MLVMINtKG) 5039 94.8 15.5 0.8 7.45 29.6 116.4 5930.0 280.0 21.0 95.2 7.0 193.0 5046 95:4 14.6 0.7 7.46 23:6 105.3 4450.0 190.0 18.0 84.8 7.0 240.0 5106 95.4 18.0 IlKM9 7.36 26.6 97.2 4850.0 140.0 13.0 96.5 9.5 208.7 5109 96.4 15.3 w)( kN 7.42 25.9 93.4 6910.0 200.0 23.0 97.8 9.0 195.6 5143 94.8 16.3 0.8 7.45 21.1 115.4 6320.0 180.0 16.0 91.2 9.5 184.0 6014 93.6 14.2 0.6 7.46 27:7 94.3 4920.0 150.0 17.0 72.8 7.5 160.0 6016 94.8 15.5 0.5 7.45 22.8 112.6 4880:0 150.0 14.0 85.6 7.0 152.0 6018 96.2 14.6 KKMN 7.40 23.8 93.9 6280.0 120.0 14.0 69.2 8.5 304.6 6038 94.2 16.3 MMNN 7.40 25.4 86.4 7210.0 280.0 26.0 /10.0 7.5 187.0 6039 94.0 15.6 0.8 7.44 28.5 108.0 6120.0 I50.0 I6:0 81.7 9.0 226.0 MEAN 94.96 15.59 0.70 7.43 25.50 102.29 5787.00 184.00 17.8 88.48 8.15 205.09 5D 0.92 1.10 0.13 0.03 2.69 10 _60 953.61 56.02 4.3 1 2.26 1:06 44.01 H _ 10 10 6 10 10 10 10 10 10 _ 10 t0 10 FE T9nOtrOR
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m m m A a m 2 2 APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 100 DAYS EXPOSURE H2 WASHOU T DOG -------------ARTERIAL BLOOD G_ASES-------------- 02HB HB COHB PH PC02 P02 VOL. TO 2: N2 CLOSING ----VOLUME---- VITAL CAPACIT PHASE III Y SLOL'E MINUTE VUI.UME No. (:) (G/100 ML) (7.) (MM HG) (MM HG) (ML) (ML) (Y.) (ML/KG) (( N2iL) (ML/MINlK G ) .5039 92.2 11.0 1.5 7.41 30.7 79.1 9763.0 200.0 15.0 85.8 7.5 _ _ 224.3 5046 89.5 >E+~~>4 1.3 7.41 32.5 75.2 8834.0 160.0 16.0 70.3 7.5 397.7 5143 94.8 *!~~K 0.2 7.44 30.3 105.9 6545.0 370.0 35.0 84.8 9.0 145.2 6014 90.5 11.0 0.9 7.43 33.6 74.0 '7920.5 160.0 17.0 ' 72.8 7.0 196.2 6016 93.8 11.4 1.6 7.40 31.7 88.1 7464.8 210.0 19.0 93.3 6.5 318.3 6039 86.6 10.6 1.8 7.43 37.0 64.6 4600.4 180.0 22.2 70.4 9.5 188.7 MEAN 91.23 11.00 1.22 7.42 32.63 81.15 7521.28 213.33 20.7 79.57 7.83 245.07 SD 3.01 0.33 0.58 0.02 2.45 14.32 1810.82 79.41 7.5 9.70 1.17 94.48 N 6 4 6 6 6 6 6 6 6 6 6 6 ` z9zf:ovoR
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. ~ ~ . in A A JpS m n ~,r SA m a a 2-mA APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 200 DAYS EXPOSURE N2 WASHOUT DOG -------------ARTERIAL BLOOD GASES-.-------.--.---- 02NB NB COHB PH PC02 P02 VDL: T0 2'l. N2 CLOSING ----VOLUME---- VITAL CAPACITY PHASE III SLOPE MI11U1E VOLUMF 110. (:) (G<100 ML) (~) (MM HG) (MM HC) (ML) (ML) ( :) (MLiKG) (% N2 iC) (11LiMIi;/KG) 5039 92.8 17.8 0.6 7.39 31.1 79.5 6933.6 400.0 28.0 84.1 _ 5.0 2~i9.0 5046 95.6 13.9 0.9 7.45 30.0' 96.4 5190.5 250:0 22.9 75.2 7.5 181.2 5i06 87.8 18.1 1:4 7.36 33.3 60.1 4944.9 250.0 23.5 84.1 10.5 213.5 5109 83.4 18.0 1.4 7.39 37.5 53.9 6465.7 280.0 30.4 97.8 8.0 578.0 5143 94.6 17.6 0.7 7.44 29.7 85.4 5929.4 290.0 27.6 80.8 8.0 , 196.3 6016 93.7 17.2 1.4 7.39 25.6 79.2 5336.3 240.0 19.7 101.7 6.0 340.2 6018 92.4 NNK)( 1,2 7:41 31:5 69.3 5623.2 370.0 30.8 74.4 7.5 357.7 6038 93.2 17.5 0.3 7.44 26.7 62.9 4441.6 290.0 26.8 102.8 12.0 306.3 6039 90.0 16.7 1.6 7.41 30.1 68.1 4233.6 360.0 35.0,. 108.4 11.0 245.6 MEAN 91.50 17.10 1.06 7.51 30.61 72.76 5455.41 303.33 27.2 89.92 8.39 296.42 51) 3.85 1.37 0.45 0.03 3.49 13.47 889.09 58.74 4.7 12.83 2.33 122.51 N 9 8 9 9 9 9 9 9 9 9 9 9 S I I r-- cgzcovoe
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APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR TIIE CODE 68 GROUP AT 400 DAYS EXPOSURE DOG ------ 02HB N0. (i) 5039 97.3 5046 96.3 5106 92.4 5109 96.3 5153 97.0 6014 89.8 6016 97.9 6018 93.4 6038 95.8 6039 92.4 h N2_ WASHOUT ------- ARTERIAL BLOOD G_ASES-------------- HB COIIB PH PC02 P02 (G_/I00 ML) (7.) (MM HG) (MM HG) 17.1 1.6 7.44 27.7 91.4 17. 1 1.4 7.37 31.2 73.6 17.3 1.6 7.45 29.1 88.2 16.1 1.6 7.42 29.8 81.3 17.0 1.9 7.42 32.7 93.4 16.3 1.6 7.39 32.9 59.5 16.2 1.4 7.44 3i.9 101.1 17.3 1.8 7.44 32.1 68.2 15.5 1.7 7.37 32.2 82.0 16.8 1.5 7.41 31.4 62.1 VOL. T0 CLOSING VITAL PHASE III HEFIIITE -2: N2 ----VOLUME=--- CAPACITY SLOPE VOLQtlE (ML) (ML) ('l.) (19L[KG) (: H2/L) (ML1191NiKG) 6934.0 400.0 27.6 87.9 4.0 39L.7 6063.0 220.0 20.2 80.7 8.5 320.1 5547.0 220.0 18.0 94.6 9.0 175.9 9653.0 240.0 26.7 90.9 6.5 213.9 6329.0 270.0 26.0 81.3 11.0 219.4 4343.0 150.0 16.0 75.2 7.5 185.8 6847.0 130.0 12.5 85.3 8 .5 368.3 7862.0 330.0 32.0 73.1 7.5 .i09.3 4368.0 330.0 30.6 97.3 8.5 247.9 5962.0 250.0 26.5 81.2 9.5 437.5 6390.80 254.00 23.6 84.75 8.05 286,64 1584.71 82.89 6.5 7.96 1.18 92 .61 10 10 10 10 10 10 ~ MEAN 94.86 16.67 1.61 7.41 31,10 80.08 51) 2.68 0.61 0.16 0.03 1.70 13.94 j 11 to to to 10 to 10 C-3 cm ~ -rtI ~ ~ -~ ~ v97EOv08
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APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 600 DAYS EXPOSURE --------rr------ARTERIAL BLOOD GASES------------------ ___ N2 WASHOUT DOG 02N0 HB PRE C0118 POST COHB PH P-C 02 P02 VOL._ TO 2`/. N2_ CLOSING ----VOLUCIE---- VITAL CAPACITY PHASE III SLOP-E MINUTE VOLUME N0. (i) (Ot100 ML) (%) (%) _ (MM HG) (MM 11G) (ML) (ML) ( :) (ML/KG) (% N2tL) (MLip1I11iK( 5039 96.8 16.9 2.1 1.9 7.34 37.7 96.4 6717.0 200.0 13.0 85.4 6.5 307.0 5046 97.3 16.5 2.2 1.5 7.35 • 41.4 98.2 5875.0 250.0 22.0 76.9 11.5 345.3 5106 99.3 17.7 2.2 1.9 7.38 33.4 93.4 4674.0 290.0 25.0 85.9 8.5 247.5 5109 95.4 17.0 2.0 1.9 7:35 38.7 66.5 5967.0 420.0 40.0 104.0 6.0 377.6 5143 98.5 17.3 3.4 2.0 7.07 40.0 92.1 5788.0 170.0 16.0 75.4 9.0 272.3 6014 93.0 16.8 2.2 (.7 7.37 39.7 74.6 5590.0 130.0 14.0 67.4 8.0 216.7 6016 99.3 15.7 1.8 1.6 7.41 32.6 101.9 6966.0 170.0 14.0 96.0 6.0 323.4 6018 97.4 17.3 1.8 1,9 7.44 35.8 78.1 6421.0 110.0 10:8 75.6 7.5 194.1 6038 96.7 15.4 1.6 1.7 7.33 42.3 70.3 4600.0 )(XHN)4 xK)(m 128.0 13.5 290.8 6039 99.0 16.9 2.4 1.6 7.37 35.7 94.8 4860.0 190.0 19.0 88.2 12.5 441.8 MEAN 97.27 16.75 2.17 1.77 7.34 37.73 86.63 5745.80 214.44 19.3 88.28 8.90 301.65 SD 1.98 0.72 0.49 0.17 0.10 3.29 12.89 831.73 94.88 9.0 17.6 1 2.72 74.92 N 10 10 10 10 10 10 10 10 9 9 10 10 10 w 0 ~9zEov(lR
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. . APPENDIX 9 CON'T I PULMONARY MEASUREMENT FOR THE CODE-68 GROUP AT 800 DAYS EXPOSURE ----------------ARTERIAL PRE DL00 POST D GASES--.-----------.----- H2 WASHOUT VOL T S DOG 02NB_ NB COHB COHB PH PCO2 P02 . O 2% N2 CLO ING ----VOLUME---- VITAL CAPACITY PHASE III SLOPE MINUTE VOLUME Fio. (i) (GEt00 ML) (s:) (:) (MM HG) (MM HG) (ML) (ML) (X) (biL/KG) (Z N2/L) (ML /MINtK 5039 96.4 14.9 1.6 0.6 7.43 31.6 82.2 6880.0 300.0 20.1 88.7 6.0 _ 277.7 5046 96.7 13.2 1.3 0.4 7.41 39.9 88.3 6271.0 360.0 37:1 67.8 4.5 247.3 5106 96.2 16.1 1.7 1.4 7.37 46.2 93.2 4861,0 140.0 14,7 73.6 11.0 218.7 5109 89.6 16.0 1.4 1.6 7.39 41.8 76.5 5045.0 H*xb11 1Q0.0 8.5 478.0 5143 96.7 15.1 2.0 1.5 7.44 40,9 83.9 6181.0 xxwxx txx~ 't7.9 15.0 197.6 6014 95.8 15.6 1.7 1.3 7.37 45.3 78.6 4731.0 200.0 21.0 79.2 7.5 252,1 6016 98.5 16.4 1.9 1.8 7.41 33.7 100.1 5569.0 220.0 17.9 94.6 8.0 327.6 6018 95.4 17.2 1:7 1.5 7.39 46.3 94.0 6662.0 xxttxx axXA 85.6 6.0 293:5 6038 94.7 14.1 1.0 1.2 7.37 46.2 83.8 4828.0 xtixKx ttxxx 107.5 12.5 206.9 6039 96.0 15.8 1,7 1.5 7.38 36.3 78.5 4652.0 xxxxx xgxx 73.7 15.0 408.1 E1EAN 95.60 15 .50 1.60 1.28 7.40 40.82 85.91 5568.00 244.00 22.2 84.86 9.40 293.75 51) _ 2.33 1.16 0.29 0.44 0.03 5.44 7.78 859.48 86.49 8.7 12.80 3.78 90.15 N 10 10 10 10 10 10 10 10 5 5 t0 10 10 ~ !"P9 ~ ~"J .~ _.., ~ ...~ .~, , 99ZCOV0R
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` m "' M I.k. M M .l4L M m m m APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 1000 DAYS EXPOSURE ---------------- ARTERIA_L BLOOD GA_SES------------------ PRE POST DOG 02HB HB COHB COIIB PH_ PC02 P02 NO. (%) (Gt100 ML) (:) (7) (MM HG) (MM lIG) 5039 91.6 16.8 2.1 2.4 7.37 39.4 85.5 5046 87.2 16.5 2,4 2.1 7.29 41.2 74.1 5106 58.3 13.8 1.4 1.8 7.52 34.5 66.9 5109 51.2 14.7 1.7 1.7 7.58 29.4 45.1 5143 96.6 16.9 2.0 2.6 7.30 39.6 95.8 6014 93.8 16.0 2.7 2.6 7.31 37.2 86.7 6016 91,1 16.6 2.5 2.4 7.31 33.1 73.3 6018 62.0 16.0 1.9 1.8 7.56 29.8 56.7 6038 67.1 15.0 1.4 1.5 7.45 39.0 78.9 6039 81.6 16.1 1.6 2.2 7.38 35.3 58.6 MEAN 78.05 15.84 1.97 2.11 7.41 35.85 72.16 50 16.77 1.02 0.46 0.39 0.11 4.15 15.57 N 10 10 10 10 10 10 . 10 w w N N2_ WASHOUT VOL. TO CLOSING VITAL PHASE III MINUTI 2% N2 ----VOLUME---.- CAPACITY SLOPE VOLUMI (ML) (ML) (Y.) (ML/KG) f_X N2iL) (ML/f1INi1 6564.0 370.0 24.3 87.4 5.5 150.9 7286.0 190.0 17.3 71.0 8.5 208.9 4708.0 350.0 28.4 98.4 7.5 158.4 5698.0 210.0 21.6 98.0 7.0 575.5 7177.0 280.0 23.7 86.1 12.0 194 .8 7594.0 290.0 28.4 80.3 7.0 172.3 5162.0 130.0 9.1 109.2 8.0 295.7 7414.0 1s~xx>t xxxa 75.4 8.5 223.3 4840.0 K!1K~K iF8+1~ 123.2 8.5 240.8 4838.0 270.0 23.3 104.5 5.0 276.3 6118.10 261.25 22.0 93.35 1183.56 80.97 6.3 16.31 10 8 8 10 b 7.75 249,6! 1.93' 124.0( 10 10 L9zzw E0V0R
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-- --_ y~ ~ r~ m n m APPENDIX 9 CON'-T- PULMONARY MEASUREMENT FOR THE CODE 68 GROUP AT 1100 DAYS EXPOSURE ---------------- ARTERIA__L PRE BLOOD POST GASES------------------ N2 WASHOUT OL TO CLOSING VIT PH SE III MINUT DOG 02HB HB COHB COIIB PH PC02 2 P02 V . 27. N2 ----VOLUME---- AL CAPACITY A SLOPE- VOLUM NO. (i) (G<100 ML) ('/.) (%) (MM HG) (MM HG) (ML) (ML) (%) (ML/KG) (Y. N2/L) (MLtMItI< 5039 53.0 17.4 2.4 2.1 7.52 33.0 _ 47.8 7855.0 240.0 16.3 87.0 5.5 282.5 5046 58.0 16.4 2.0 2.0 7.49 36.8 54.9 7899.0 150.0 20.3 fi8.0 5.5 2_43.8 5106 90.4 2.9 2.8 7.33 31.8 62.5 4221.0 200.0 16.4 92.4 7.5 184.9 5109 90.4 ~>F?tk 2.7 2.6 7.39 30.6 58.4 5382.0 180.0 18.9 97.9 8.3 335.6 5143 66.5 16.6 1,7 1.9 7.42 37.7 72.4 6564.0 400.0 35.4 81.9 8.5 206.0 6014 60.4 17.2 2.0 2.2 7.46 30.9 50.9 7313.0 xitxxx xxxat 68.7 7.0 334.6 6016 63.2 16.3 1.9 T;7 7.54 27.9 50.9 8510.0 100.0 8.8 87.0 8.0 324.8 6018 92.8 KK*K 2.8 2.4 7.34 35.8 67.8 6304.0 200.0 18.5 75.5 6.0 276.9 6038 uxxX xt~xx 2.4 2.2 NxxN 38.0 48.4 5078.0 220.0 19.8 103.7 7.0 332.6 6039 61.0 16.7 1.7 2.1 7.52 28.7 51.6 5141.0 170.0 18.1 83.2 11.0 367.0 I MEAN 70.63 16.77 2.25 2.20 7.45 33.12 56.56 6426.70 206.67 19.2 82.53 7.43 288.8 SD 15.86 0.44 0.45 0.33 0.08 3.73 8.50 1 445.13 83.22 7.0 15.83 1.66 60,9 N 9 6 10 10 9 10 10 _ 10 9 9 10 10 10 w w L e9reovuR
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` -~-~-~ .!Y .~ ~ ,~ 1~ ,C~,"-~ -~-"~" ____ ~ -~-x--a APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR TIIE CODE 67 GROUP AT 100 DAYS EXPOSURE N2 WASHOUT DOG -------------ARTERIAL BLOOD GASES-.--.--.--.----.--- 02HB HB COHB PH PC02 P02 VOL: TO 2'/. N2 CLOSING ----VOLUME---- VITAL CAPACITY PHASE III SLOPE MINUTE VOLUME NO. 6028 (:) (G<100 ML) (i) (MM HG) (MM HG) 91.3 18.6 1.8 7.40 34,7 83.4 (ML) 5616.0 (ML) 300.0 (Y) 33.0 (MLiKG) 75.9 (k N2tL) 17.5 (Ml1MIlitKG) 277.2 6030 93.2 16.3 0.1 7.42 28.2 90.5 6041.5 220.0 23.0 75.2 10.0 180.6 6031 88.0 17.0 . 2.0 7.38 32.2 81.9 6307.2 130.0 16.0 66.7 32.0 151.2 6032 94.3 17.3 7:6 7.39 31.3 87.3 6458.4 210.0 24.0 80.9 10.0 141.4 6034 91.4 18.9 1.0 7.35 28.8 92.3 6264.0 170.0 15.0 89.3 1 2.5 257:6 6035 93.0 17.4 1.3 7.45 27.5 87:5 6436.8 200.0 22.0 72.8 _ 9.5 172.8 6037 92:9 16:2 0.6 7.37 31.7 89.3 7000.0 120.0 13.0 93.7 15.5 404.2 60(10 92.2 16.8 2.0 7.42 29.1 86.6 7063.2 120.0 14.0 61.5 10.0 288.0 MEAN 91.48 16.383 1.23 7.40 31.23 83.82 6677.28 2_29.80 22.8 89.06 13.13fi± 309.29 SD 2.49 1.54 0.77 0.03 3.71 8.75 1094.96 95.88 7.1 17.18 6.47 120. 85 N 50 50 49 50 50 50 49 50 50 50 50 _ 50 7 ~
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APPENDIX 9 GON`-T.. PULMONARY MEASUREMENT FOR THE CODE 67 GROUP AT 200 DAYS EXPOSURE ------------- ARTER IAL BLOOD GASES-------------_-_ N2_ WASHOUT VOL. TO CLOSING VITAL PHASE III MINUTE ' DOG _ 02FIB HB - COHB PH PC02 P02 2'/. N2 ----VOLUME---- CAPACITY SLOPE VOLU19c NO. ('/.) (G/100 ML) (X) (MM HG) (MM HG) (ML) (ML) (Y,) (ML/KG) (X N2tL) (MIiI91Nii;G) 6024 94.8 7.42 30.0 94.3 4880.0 490.0 37.0 117.3 7.0 215.0 6026 93.0 18.6 1.9 7.35 37.3 79.7 8467.0 330.0 25.4 100.0 5.5 2i5.8 6027 93.0 19.8 2.2 7.40 42.6 77.9 5642.0 270.0 28.4 86.4 12.0 327.9 6028 93.4 *xxx x*Ha 7.38 33.9 81.7 5983.2 130.0 14.8 80.0 14.0 392.7 6030 91.4 17.5 1.2 7.40 31, 1 74.5 7236.0 200.0 21.3 78.3 15.0 216.0 6031 93.8 16.0 1.4 7.41 33.4 90.4 5616.0 160.0 20.5 74.3 30.5 181.0 6032 92.3 16.1 1.6 7.40 33.4 76 .7 6307.0 280.0 31.8 83.8 10.5 306.5 6034 92.8 16.0 1.0 7.40 27.3 76.2 x>Exasitxx 450.0 34.6 113.1 8.0 229.1 6035 91.8 15.9 1.7 7.43 29.7 73.2 t4xxkxxx 360.0 3.6 90:9 9.5 219.9 6037 94.4 16.4 1.0 7.45 27.1 77.7 6977.0 290.0 32.2 87.4 10.0 337.7 6040 88.6 17.4 1.4 7.41 33.3 61:7 6336.0 200.0 22.5 68.5 14.5 372.2 MEAN 92.35 16.12 1.18 7.40 32.16 81.95 6305.188+ 246.048 23.6 89.68 12.940+ 304.20 SD 2.62 1.39 0.57 0.04 3.56 11.80 1075.60 92:29 7.1 15.07 6.04 83.96 N 53 51 50 53 53 53 51 53 53 53 53 53 R v=0VUR
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APPENDIX 9 CON'T PULMONARY MEASUREMENT FOR THE CODE 67 GROUP AT 400 DAYS EXPOSURE DOG -------------ARTERIAL BL00D GASES-------------- 02HB HB COHB PH P-C02 P02 N2 WASHOUT VOL. TO 2'!. H2 CLOSING ----VOLUME---- VITAL CAPACITY PHASE III SLOPE MINUTE VGL1.119E N0. ('/.) (Gl100 ML) (`/.) (MM HG) (MM HG) (ML) (ML) (R) (ML/RG) (% N2/L) (ML/MIN/KG) 6034 93.3 18.2 1.7 7.42 28.7 86.7 7238.0 370.0 25.6 111.6 6.0 293.3 6035 95.4 16.1 2.6 7.46 30.4 92.7 '8074.0 200.0 21.7' 70.7 14.5 275.8 6037 89.7 17.0 1.9 7.52 30.4 65.0 6468.0 280.0 28.5 94.2 13.5 357.5 6040 95.6 17.6 1.7 7.62 25.0 94.9 6776.0 250.0 25.2 73.3 11.0 462.8 8 s 3+ 3+ s+ MEAN 92.06 15.97 2_.07 7.41 30.79 77.17 6949.09 283.49 26.9 88.58 12.00 372.70 SD 4.14 1.42 1.06 0.05 3.69 12.63 1205.51 98.49 7.3 12.38 4.20 112.73 H 46 46 44 46 46 46 . 46 43 43 46 46 46 9fAzcOvOR
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11 CE1'a~r1011ri'1AL APPENDIX 10 REFERENCES HEMATOLOGY AND HEMOSTASIS Ez^y,thr.ec~ te Count, Leu'eocyte Count and gemegZo: i~n - Coulter Electronics, Inc., Hrf'aleah, Flordia if &ematocrit - Mialle, John B. 1972. L'aborator Medncine;. Hematology„ 4th ed. p. 1!205. If f PZateZet adr.esiveness - Salzman,, E.W'. 1963. Measurements ments of'platelet adhesiveness: a sample in vitro tech- nique demonst'rating, an abnormality in Von WiTliebrand''s disease. J. Lao. CZin. Nred. 62':724-735. ~ PZateZet Aggregation __ Born, G/V.R. 1962. Aggregation of blood platelets by adenosine diphosphate and its rever- sadl. Nature. '194:, 927-9291. I I ' I I 4 I PZateZet Cozozt - Technicon Instruments Corporation; Tarrytown, N.Y. PZateZet Rererence N Assay - Wiintrobe, M.M. 1967. ClinicaT Hematology, 6thied. Lea andiFebiger, Philladelphia, Pa. p. 303. CLINICAL CHEMISTRY AZbtanin - Doumas, B.T., D.D. Ulmer, and H.GI Bigg$. 1971. Standards and the measurement of serum albumin with bromcresoT green. CZ'in. Chim. Acta. 3'1:87-96. BZood Ure Ni tragen - Ma rsh „ W. H., B'. Fi nge rh ut and H. Mi l l er. 1965. J., CZin. Cherr.., 11 (6). CaZciur7i-- Kessler, G., andl M. Wolfman. 1964. An auto- mated procedure for the determination of caillci'um and phos- phorous. CZin. C74er.r. 10:,586-703. CFiaZesteroZ - Levine, J., S. Morgenstern, and 0. Vllastel'ica. 1968. A direct Li'ebe mnan - Burchard method'for serum choles- terofi. Automation in anal'yticall chemistry. Technicon Sym* posial„ 1967, White Plains, N.Y., Med::ad :nc., pp 25-28.. I -34C-
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I I I I 1 1 I J CURTIDfNrIAL APPENDIX 1'0 CON'T REFERENCES Cre4tun.e Pnosphakzr.cse _ RosaTki, S.B. 1967. A'ni improved proced'ure for serum creatine phosphokinase determination. J. Lab. CZi:rs,. Med. fi91:5961. Creatinine - Chasson, A., H.T. Grady and_MLA'. Stanley. 1961 Adn. J. CZ'in. Path. 35:83. GZucose - Bittner, D.L., and J. Manning. 1967. Automated neocuprovine glucose method: critical factors andlnormal values. Automation in analy,tical chemistry. Technicon ' Symposia,1966, Uoll. 1, Whit'e Plains,,N.Y. Mediad Inc. pp 33-36. GZutom•t;c Qx:Zacetie Trmesarrnase and GZuta^;t:cPyruvate '"rar:s=.in:se _ kessler„ G~ „ R. Rush, L. Leon, A. Delea, and R. Gupiol'a. 1971. -Automated 340 nm measurement of SGOT,SGP'f and LDH. Advances in autamaGed analysis. Technicon International Congress, 1970, VoT 11, , Miami, Florida. Thurman Associates. pp67-74. Inor^anic Phospnorus - Hurst, R. 1964. The determination of nucleotide phosphorus with stannous chloride hydrazi'ne suTphate reagent. Can. J., Biochem. 42:287-292. L.atic De'r.ydrogenase - Wacker, N., D.D. Ulmer„ and B.L. Va1Te_ 1956. Metalleonzymes and Myocardial Infarction. New BnoZan4' J. Med: 255:449. Serwn Protein, ELectroahoresis - Zip-Zone cellluTose acetate.method',. Helena Laboratories, Beumont, Texas. TotaZ Protein - Skeggs, L.T. J?-., and1H. Houchstrasser. 1964. CEin. Chem. 10:918. PULMONARY PHYSI'OLOGY Ni'trogen Washout , Luft, V.C., E.H. RoorbacFi,, and R.E. MecQuigg. 1955. Pulmonary nitrogen cl-arance as a criterion of ventilat'oryy efficiency. Am, Rev. Tuoerc. 72:465-478'. Singue Breath Nitroaen - Mead, J.W. andlJ.L. Wittenberger. 1953. Physical properties of humamlungs measured duringispontaneous respirat,ion. J. Apai'. PhysioZ. 5:779-796. -347-
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UNThENTlAd APPENDIX 10 COPdT'D REFERENCES E Comroe, J.H., andlW'.S. Fowler, 1'9511. Detection of uneven alveollar ventilation during a single breath of oxygen. American J. of ^4ed: Apr. 4 :408-47 3'. Lenahan, J. and Smith, K. (T976)'. "Hemostasiis Seminar," 111th Edhtion, pg. 50; General Diagnostics Division of Warner- Lambert Co., Morris PTains, N.J. 07950. Levine, P.H. (1973). "AniAcute Effect of Cigarette Smoking on P1'etelet Function."' Circu?auzon 48!:619. Mead, J., and C.R. Colliier. Relation to volume hi'story of lungs to respiratory mechanics in anesthetized dogs. J. AppZ. Phy~ioi. 1'4:.669-678', 1'959. Meadl„ J. and E. A. Gaensler, Esophageal and pleural pressures in man upright and supine. T.ApgZ'. Physioi. 114':81-83, 11959. Millic-Emiili„ Ji., J. M'ead, and J.M. Turner. Improved technique for est'imatingipleurall pressure from esophageaT balloons. J. AppZ. FhysioZ. 19:207-211, 1'964., Swatman, L.E. "Shouldi You Do Qualitative Screens?" Med~c Z Labs:pg. 27. 0 1K I -3410-
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120 110- 100 ~ 90 ~ 80 70 _ w ~ ~ ~ 60 ~ N CY 50 - ~ c 40 - 30 - ~ ~ 20 10 - FIGURE 1 CODE 13 Pa02 aNn PACOZ Cal X-X CADE 13 (LOw) 0-0 CODE 33 (GONTRUL) 100 200 400 600 800 1000 LV1YS OF Fxf'OSUf?E 12D0 1400 1500 a VRZCOVOR
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AN m m fm ~ FIGURE 1 CON'T ~ z i ('ADE 11 PA Oz aNn Pn COZ M~, L X X-X CODE 11 (MID) 0-0 COCE 33 (CONTROL) ~-, --~ 100 200 400 600 800 i000 ]200 1400 1FM DAYS OF EXPOSURE 4 qR:cOvUR
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... FIGUW I (CaJr7NUFn) gRZE:OVUR 120-}- 110 ~- CQDE 32 PA OZ aNn P-n U12 1 _ 4 X-X CCDE 32 (t,uH) 0-0 CODE 33 (coNraoL) 7 100 200 409 C/0(ll 800 1000 ]200 DAYS OF D(POSUFE c 1h00 15(Xl
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~~QZ[:ot,oR
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, w W 100 200 F1W. 2 CODE 13 N2 WASHOUT TO 2% 1100 609 DAYS OF DQ 05URE = = m m m m m m " X-X fADE 13 (LOw) 0-0 CO(E 33 (CQNTROL) 1401) 15M RNUOVUR
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CGNTi]DEMTIAL 9 9 11 I It I I g mi cl I c I cli 9 LL tm 4 8 r p o ppp ~^ op p p p ~ O~ C ~~~. O O~ C O O~ O~. ~. O. Gi. CO', I\,. ts ~ u"i~ z7` f.1~ (lj~ ,-y~ (W h(1'1mA -35G O
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0 100 200 FIGH 2 (EarmrniEn) COCE 32 N2 WASHOUT TO 2% ~-- --x _ ~- -.-z 1{09 Dt1YS OF D6'OSU(E X-X CQDE 32 (HIGH) 0-0 CODE 33 (CONTROL) -f-- f ~ 12{~ 1400 1`M c7la c,•_.3 rY-a QGZCQVUR
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FIGUfC 2 (EowiwuEO) CQpE 67 Nq WASHOUT TO 2% X-X COQE 67 fPND) g000~ 0--0 fADE 68 (FVq corrreoa.) 10,009 9,000 7,000 6,000 5,000 4,000 3,000 2,090 11000 p 100 200 600 DAYS OF DMSUfC- 1Q09 1100 4 IGZEOV06?
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k I f CLCSIGJ6~VOL,~%VITAL~C:APAC~~ITY !(~9~L,~V;) I 8 T ~ 8 vn o,G o`G+' ~~ o r , ' ~- a a u ~ ~ ~ ID ~ ~ w ~ ~ o x b ic F~ 8 R m " I I a I
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. I f I I I I r.a v 9 9 ~' O M! ~.~. ^il. ~. 1' +I (A') v) AlI7Hdv3 lVl;A/"10n SPIVSDID -3~~- i
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CCITILDENTiAL II . 9 I I 9 L7 X I LL 14 ;- 111 - , --f -,-' M~ M. N ~I ti. ~. N~ (',1''l tJ A'~l,I'7ddV3 ~ 'itr'lIA/~'7Dn' 9NI~S©l) 11 9 i. -:i5~-
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~CLOSI~Nu ~V©L.7V~ITAL ~CAPAC~1!TY ~(Z'~C:V.)
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4 FIGIAW 4 COCE 13 VITAL CAPACITY X-X CODE 13 (LOW) 0-0 COCE 33 (CONfROL) 100 200 1100 600 800 1000 m lim lun DAYS OF E)6'OSUfE JEii €:0v[l!3
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.os a.a Ara ~ m 120 110 - 100 90 - a0 w 70 N ~ Y 60 \ 50 - ~ ~ 40 - 30- 20 - 10 - i_ i ..a im m m m m Mi M = MM FIfUB,E 4 (Ca+rmn,m) i [U 11 VITAL CAPACITY - 100 200 !100 600 DAYS OF E)4'OSUFE X-X CODE 11 (rtrn) 0-0 W 33 (CUNTROL) 1400 1`M c-.) r1t) ~-. . =Yi ~ f--G, %rf: 0 v 0 S
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I 120 110 - 100 90 80 - 70-_ c, 60 ' ~ 50 € 110 30 - 20 - 10 0 t362%ovos F1Uff 4 (CoerriNixn) [OUE 32 VITAL-CAPACITY 0::=- 100 200 400 600 Bl1YS OF Dff'OSUfE X-X CODE 32 (H1cN) 0-0 CODE 33 (CONTROL) 800 1000
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FIGURE 4 (CoNriwEn) w ~ i CQEF_ 67 VITAL CAPACITY 100 200 40(] 600 DI1YS OF DQ'OSUW X-X PADE 67 (PMO) 0-0 CppE 68 (PMO CONTROL) 7000 1100 N10 Gfi7.cov()Jq
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FIGURE 5 CODE 13 P-f UISE 1 I I SL.OP€ DAY$ OF D3'OSURE 40 - 35 30 - 25 - 20 - 15 - 10 ' 5- 100 200 400 X-X CODE 13 (Law) 0-0 W 33 fCOKiROL) it- 1000 4 Onccov()f3
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MUUMUU MMEMKKKK KKi A FIGIA(E 5 (CaTIMM) FADE 11 PWIS€ I ! I SLIIPE X-X E(YlE 11 (MID) Q-0 CODE 33 (corrrrsot_) ~ J ~ 8-F 100 300 hpp 600 800 1000 ]'lil0 lto) 1500 MYS pF D4 CISpRE r- - IoCeoVoR
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1 FIGIA'E 5 (CartirLEn) COOE 32 PIIASE III SIIIF?€ 110 35 -30 - ~ 25 - ~ 20 - 15 Br 100 200 0---- 400 [1!iYS OF QU'06UW zQCCOVUQ X-X CODE 32 (HicH) 0-0 COD€ 33 (corrraa.) x 1000 1200 -=1=---i 1'm 1500 a a A
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