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HARVARD MEDICAL SCHOOL ~ BETH ISRAEL HOSPITAt D[rARTM[NT OPY[DiCINi. DIVIRION, OP. R[5TIRATOR1'DISL]ClR1 i OARYI'L. NUR=R..IM1D..,CNIt/. Charles E. Iloldsworth,, P'h. D. American Petroleum Institute 2101 L Street, ri1.W. Washington, D.C. Dear Dr., Holdsworth, Marling R'd d setl:~ ' S[TNIfRAiL NOSPIiTAL. 030, RROOKl1NF AVlNUR WRTON.. WAf/ACNUf[7Tf.0>t'Rt! 1.17), 73s-23,91 October 14,~ 197g: Enclosed is our proposal in response to the invitation to bid!tolth,e American Petroleum Institute on the 1°Carcinogen2c;-Potential of Key Petroleum Products and the Carcinogenic Potential of' Petroleum Lubricants.11 We have subm,itted' our proposal as a combined appl'icationif'or the two studies. I attach with this letter alpropose ' Budget Summary for studying the key petroleum products alone (6 compounds), the petroleum lubricants allone (8' compoundLs),, and a combined study for alli products (14I compounds). The budget is submitted in this format„ as indicated in your Invitation, to Bid. A more:detailed' cost analysis has been prepared, of course„ on, which toibase these summaries, and is available on request., The overhead!aillowance on our research awards through:H'arvard University ranges fromil0o to 70a., It is anticipated that the overhead will continue tolfall in the Univers3ty., The suggested amount allowed'herein, willi be negotiated directlXbetween the sponsoring,organi~zation„ theAm,erican, Petroleum Institute, and th~eg~rantee,Harvard Medical School, if our proposal in favorably reviewed., Our resources at Harvard Medical, School and the Harvard'SchoolI of' Public Health are unique, and represent considerable depth andiexpertise toperf~orm the researchloutl,ined., In addition, we,hiave had an excellent relationshig with industrial sponsoring organizations, and our research program is now second iniaggxegate industrial support in the history of Harvard Medical School. We hope our proposal meets with, your satisfactioniand is favorably reviewed'. We would like to undertake this research on, your behalf. If I can provi!deany additional information to you, or be of any further service to you or the AmericaniPetroleum Insti~tute on the research, problem, please do not hesitate to call on me directly., Sincerely yours, ~--~a At Cary L. Huber,, Wl,. Di., , Chief Respiratory Diseases, Unit GLH/mks t

BUDGET SUMMARY C Key Ptodtacts Lubricants Combined Study Direct Costs (6 Compounds)'* (8 Compounds)+ ('141 Compounds)'a 1. Salaries, wages $30,000~ $40,00'0. $59,0D'0 2. Fringe benefits 6,000, 8,000 '' 11„800' 3. Equipment --- --- --- 4. Supplies 10, 78'6 13, 258' 726 20,726 5. Animals and' AnimaL Care S,1112 ' 6,369 9,612 6. Travel • 500, 5'00 500 7. Indirect Costs°i 36,840! 47,709 66,835 TOTAL, $89, 238 $115, 836 $1!68',,473 *Carcinogenic potential of key petroleum products {Carci:nogenic potential of petroleum lubricants l ACombined Study - Carcinogenic potential' of key petroleum products andm petroleum lubricants oThe:ind"arect costs of overheadifor Harvard University at an off-campus location are subject to negotiation between the grantee and the sponsoring organization