Tobacco Documents Online

CLlIV!'CA L R L'SEA R CHI Abstract Reproduction Form. Ameriean,Federation of Clinical Research, (name of organizat ion. selected from iust on form letter oCtransmittal): llhis abstnctis submitted to: TYPE name, adllhcss, andl telcphone number of author who should recciiac correspundcncc in Box: A and contpletc Boxes, B, C and D: Telephone 61I7.-735-2391 617-965-2406 (Area code)) offtce (#rea~.code)~.a home~~. B orta January 5. 1978'. Pbymont ($4O.t)0): L"' Check'.nu:mtier lnq~ purchase~e ordev ~num~ber~ tssued ~ by. (name of ~.institution)', A copyof~~this abstnsC~must baattached~e to original purchase order ~ to aid in idon. ~ tification. A PFame, Ami-Hai Rubin, M.D. Address Resniratory Diseases Beth Israel Hosnitall 330 Brookline Avenue Bost:on:,, Massachusetts 02215~ C CHECK ONE (fov national.meetingsl onty) Q Prefer , poster session presentation ~IA~ Consider forposter, session iflnot ' selected!for,orat presentation~ 10 tb.not'o consider for postenr session under anyy circumstances - , CHECK SINGLE SU@SPECIAl17 I CLASSIFICA Tf0'Nr. _ Cardiavasaular« (`na~) -L Clinical Epidemiology - ClinicallNutrition - Clinicall pharmacology' - Dermatology - Endocrinology (see rule 5) - Gastroenterology _ Genetics: - Health Care Research - Hematology - Hypertension - I'mmunology & Conn. Tissue - Infectious Disease - Metabolism (see rule 5)! - Oncology - Pulmonary - Renall& Electrolyte •'For abstracts submitted toCardio- vascularanly;.select..sing(esubcatr.gory and entercoddr no. (t!L):ln sp••,ace..above: (0),Cliniva; (2): Dasic, Science; (3) [lectraphysioldagy-Dysrhythmias; (4) Echocardiagraphy; C Radiotogy-Radionuclidesc (4)ea SubctassifK~ation ic dcsigncd to.aid in revicwimgpnoccasunlyand, is independent ul',prugram .cleatkm:, i Rcvdr.ad Jno.• I'P!7 THE EFFECT OF TOBACCO NICOTINE CONTENT ON CIGARETTE'SMOKING BEHAVIOR IN MAN. A. Rubin*, V. Mahajan,•M'. Goldman*, G. Sornberger and'G. Huber. Department of:Medh'.cine, Harvard Medical School, Boston, Mass. Although overall tobacco consumption:is at an all time high:in this: country today, there is,a~trend toward more common use of low tar cigar- ettes. Nicotine accomodation„ in part a function of cigarette,tar content, is considered to be an important determinant in smoking,behav- ior. However, limited data ex,ist on the effect of nicotine content oni individuad smoking patterns. To study this,,10 healthy males smoked 2' different research tobacco cigarettes containing,a,high and! a low concentration of nicotine, as well, as their own commercial brand'ond different days. Tidal volumes and smoke inhalationiprofiles were mea- suredlby applying magnetometer:s to the rib cage and abdomen to~quantify ' volume displacement of the chest artdldiaphragms, respectively. -Carboxy- hemoglobin (COHb) levels were measured before and immediately after smoking.. The average puff volume did not differ with tobacco nicati'nee concentration. However, in 8'of 10 subjects the average duration of the puff was significantly increased (p a:.,001)' with low nicotine smoking„ as compared to higher nicotine tobacco.. Furthermore, breath holding dur ing smoke inhalation,was,significantiy longer (p <.005),in 8 subj'ect~ss smoking low nicotine tobacco. The average increase in,COHb was 1.149% for all the products, and did not vary'signif'icantly as a functibnlof varying nicotine concentration. Our observations showithat during,low. nicotine tobacco smoking, human smokers appear to titrate their nicotine requirements not by increasing the number or depthlof their puff volume, but by holding, the inhaled smoke Ear longer periods. This:may result in a different deposition pattern of the smoke aerosol within.their respir- atory system and the potential for,allterations,in tobacco-related disease suseeptibility:, MEMBER'S SIGNATURE . ~ Vijay K. Mahajan, M.D. (please.typw name). attrfl111 I1ti roRM, ANI) 'ri(1'. poRM l.)iTTN.R Of`TiIfAN:tiMrr I AI. M( IsT lu'. SIGNIiI) Ov AAII kUS1 14 (RU11ti!)