Tobacco Documents Online

ACU4E'HEHODYNAtNI,C EFFECTS OF CIGA'RF.TT!E SMOIQING'IN' MAR ASSESED BY NON-INVASIVE TEC11N'ICS', Sakurai T.„ Rabinowitz BD., Thorp K,.,, llluber G. and Abelmann N'.N.Department of'Hedicine, Harvard!Medical School' and Bet,hiIsraeliHospital, Boston, Nass., U.S.A',. . To elucidate the hemodynamdc stress of ciga- rette smoking„ 32 healthy aduQits aged 18 to 35 were studied non,invastvely in supinr posiitfan before and after smoking one Kentucky referenct cigarette (IQ)'[2'.5mg nicotine],and, one "nicotine free" tobacoo cigarette(NE) [Ia0.25mS,nicotine],. Both smoking,K and' NP increased'venous COUbb level, heart,rate (HR), systolic and diastolic blood pressure (SBP„DBP),to higher extent in K' ; than NF. End-diastolic and end-systolic LV d'i- 11 mensi'ons (.Dd,Ds) measured by echocardiography i increased after smoking K,, but decrea,sed after 1 'i ; ,c'.,. ~ ~~~. P... . NF. Mean Vcf increased in both K and"NF. ChanSes af'ter,smoking ( mean!S.D.)' COIIb(X,) HR(b/mtn): SBP'(mm11g) DBP(mmHg)', K +1!.0'!0'.6"R +L839** +153l0*N +110'_6+w' NF +0.7±0.5'W + 93'5% + 61 S"* + 6!5*r' c KveNF pc.,05' p<.001 p'C.001! p<'.001 Dd(mm)i Ds(pim) Bcf'(cir/sec)' K ' +1.6±2'.2'* ' +0.6x1.,6• +0'.09!0.13+* *<,.OS ' NF -01.6_*1.4!* _1.5"-1.7+M +0.07!01.14 *t 1m< ,001 KvsNF pd.001 p<.0o1 N.S'. These data suggest that,both smokinp,K'andlNF cause acute hemodynamic stress with potartial i'ncrease in myocardial oxygen consumption. Ni- coti'ne increases preload as well as af'terload. HF may conGain other positive inotropic and' chronotropic substnncea6 i f i j Sakurai,, T., Rabinowitz, B.D.,, Thorp, K.,,Hub.er'„ C. and'Abelmann, W'.H.: Acute hemodynamic effects of cigarette smoking in man assessed by non- inWasive techniques. Abstracts, VIII World Congress of'CardioLogy, Tokyo, J!apan,, p._ 402, 19'7'8'.