Tobacco Documents Online

TERMINATION PRQJ!ECTIONS' Technicality of'Termination: In the renewall agreement between Harvard University and the tobacco industry, it is stated that "...reasonabTe and' necessary expenses required to terminate the work in progress in orderly but expeditious manner shall be payable from project monies available or to be made available during the current fiscal year."' That entry is in the context, as indicated in the original agreementa of the Principail Investigator becoming,unavailable prior to the completion of the research program and a substitute Principal Investigator not being accepted by the industry. Termination other than by those conditionsiisnot covered specifically in either agreement. The agreements further state that the Principal Investigator must report annually that "all monies contributed will be expendediin the furtherance of this program as directed by the Principal Investigator" and that Harvard Medical School shall provide or make arrangements for adequate housing, services and the like. As now exists,, the situation is such that the Principal Investigator can not provide these assurances and wouldl resign1if the program cannot go forward. Phase-Out Funding: It is recommended by the Principal Investigator that any'funding in a phase out period be provided on a cost-reimbursement basis. That is to say, any monies expended would be reimbursed, provided' such expenditures are approved by the Principal Investigator before they are initiatedy in accordance with the initial agreement between the industry and the University and the renewal agreement. By'our best estimates, we are currently running "'on target"'accord!ing,to projected allocations in the first year of'renewal funding. Initial payment for the academic year July, 1977 throughiJune 30, 1978 was received last summer, and the second payment, due last January, is,still outstanding,in the amount of, I believe, approximately $311,000. We have prepared projected phase-out costs for a three-month period, effective April' 1, 1978'(i:t was communicated to Dean Meadow on March 31, 1978 that no additionall funding would be provided through the Beth Israel Hospital) through the end of the current academic year,, and!for a six month period, effective April 1, 1978 through the month of September, 1978. The three- month phase out period shouldinotdzf£er si~gnificantlyin amount from themonies a]iready allocated for this academic year. Charlesgate We'st Obligations. The current lease for our using the Charl!esgate West facility is signed between the secondary tenant, the Beth Israeli Hospital, and the primary tenant, Pitney Bowes. When the lease was renewed, it was for a three year period!, ending June 30,, 1980. The rents for the academic~years (corresponding to the fiscal' years of'the agreement) 1977-78, 1978-79, and 1979-801are $29,,700,, $30,600,, and $31,,500, respectively. This appears tobepureIya Beth Israel Hospital li'abiil~ity,, inithalt the Hospital negliected to obtain a renewal guarantee on the lease from the Tobacco Institute. The initial guarantee did1not include coverage for ann extension of the sub-lease. Should the program be terminated, any new tenant in Charlesgate West would mitigate, to some degree, the potential p. damages due on the lease. ~ Training and Teachsng Fund: The suppliemental monie awarded for the V 0 ~ academic year 1976-77, inian amount of $35,000, was provided to help E!T tJ.

Page 2 support teaching and clinical training at Harvard in the general' area of pulmonary medicine, with such funds to be used only for salaries of fellows and faculty in the Harvard Department of Medicine who are directly associated in a clinical or training, capacity with the Smoking and Health Research Program. Out of those funds, only $4,500 have been expendedi, to supplement the salary of Dr. Itzak Goldberg, a research fellow who. is associated with the program. The remainder of the monies, in the amount of $30,500',, have not beemexpended but have been allocated, in part, for projected academic salaries for the coming academic year for faculty and!felTows directly associatedi with the program. In addition, for the academi:c year 1977-78, 1978-79, and 1979-80, amounts of $50,000, $55,D001and$60,00':0' have' been alilocated f'orteachingandtrainiug~., Part, but not all, of the 1977-78 alilocation has been expended on personneli directly associatediwith the Tobacco and Health Research Program. In addition, part, but not a1I, of the amount allocated for the coming academic year (1978!-79) have been budgeted'for personneli associated'with the Tolbacco and Health Research Program. Dr. Epstein has indicated that he would l'ike to spendithe uncommitted monies in the 1976-77 budget, as well as the unspent monies in the 1977-78 budget and a large portion of the funds allocated for 1978-79', for technicians, fellows, and faculty' not directly associatediwith the Tobacco and Health Research Program. Mr. Meadow has suggested!that careful consideration be given to this matter, indicating,that "'a small amount of'oi1 properly applied may calmm troubled waters"' in the Department of Medicine for this program. Breach,of Lease: The lease between the Beth,Israel Hospital and Pitney Bowes apparently has beenibreached, in that renovations were under- taken in the building without permission from the primary tenant or the owner. Onithis basis, Pitney Bbwes has informed that Hospital that, upon formal notice, they will' have 10 days in which to correct'the structural alterations that have been undertakenito return the facility to its original condition. Pitney Bowes initiaLly offeredito release their commitment via the primary and'secondary leases, if the Hospital would do the same, withoutt any settliement for damages. Apparently, however, upon threat of suit by the Hospital,, as indicated by the owners of the building, Pitney Bowes has indicated that damages in the amount of'$7000-10,000'wouTd be requested. There is also a potential consideratiion that the industry may be asked too cover legal' fees incurrediby the Hospital in this matter. Federal Research Grants: Although the two federal grants involved are self supporting, for the most part, in terms of'their research expenditures, they could not stand exclusively on their own for two reasons. First, without the tobacco industry funding there is not enough support to maintain the professional staff requiredito undertake the research on the federal grants, in that the industry program pays, on the average, approximately 62% of all professional salaries. Second, in the context of the agreement between the University and the industry, some of the equipment needed for research on the federaT grants is owned by the industry and is used to a very limitedibut essentiali degree, on the federal grants. If the tobacco industry program ceases, federal grants will also have to be terminated. There is not, in all likelihood, any direct professional liability to the Principal Investigator or to the associate investigators, should this occur, although it may compromise their ability to raise add'itiona!S federal

Page 3 funding in the future. There would be no liability to Harvard on the termination of the grant administered through the University (via the Nartional Institute of Drug Abuse)~, in,that no full-time personnel areemployed solely for that purpose. There would!be a problem, however, on the one federal grant administered throughithe Hospital (via the National Cancer Institute) in that several technical personnel are employed on a full-time basis by that grant., The NCII progxamisfund'ed in phases,, on aa contracturall basis with the Hospital. For reasons unhnown„ the hospital has not-as yet signed the contract for the current phase„ whichibegan January 1, 1978. They have now communicated to us that they are reluctant to si:gn this contract at this time, for if they were to do so and the tobacco industry agreement were to terminate, they could not uphold their end of the contractual agreement. By not signing the contract however, they are not entitled to be reimbursed for the expenditures, committed on behalf of the NCI program. They have indicated to us that, under these cond'itions,, they would hold the tobacco industry liable for all expenditures committed on behalf of the NCI program,,,as well as for any unemployment coznpensation expended on the termination of the employees in the NCI'research project. Professional Appointments: Most of the investigators in the Tobacco and Health Research Program are members of'the faculty of Harvard University througli1what are called "term appointments.'"' Most of these appointments are for a three year period, and!as such, carry an obligat3on by the University to the investigators. According to the letters of commitmentt from Harvard to the research staff' (see example enclosed), the appointment is contingent on the availablility of funds fromisources outsiide of' the University. If such funding ceases during,the period of'the term appoint- ment, the appointment can be assured only for a limited twelve month period after writteninotic to this effect. Dr. Epstein has communicatedito us (enclosed)', that th~isIiabiliitywould belong,tathe tobacco:industry, but that indeed is not the case. Actually, the liability will belong to the Department of Medicine if program support is terminated.

AIN Anticipated Obligations of Program Termination Phase out period ---= Beth Israel 3-month 6-month 12-month proposal (1) Schedule 3 Salaries and fringe benefits: Professional (2) 88,000 154,400 253,100 382,650 Administrative and technical 11,600 11,600 11,600 17,000 Unemployment (3) -- -- -- 19,000 Charlesgate expenses: Rent 7,600 7,600 7,600 62,100 Taxes - 2,200 2,200 2,200 15,000 Maintenance, security and service contracts 1,200 1,200 1,200 5,000 Utilities 2,700 2,700 2,700 2,700 Restoration of premises 5,000 5,000 5,000 5,000 Moving and storage 10,000 10,000 10,000 10,000 Contingency 10,000 10,000 10,000 10,000 Totals before unpaid expenses 138,300 204,700 3DS,40(l 5-..28,450 Add: Unpaid expenses since 1/1/78 (approx.) 234,000 234,000 234,000 234,000 Totals 372,300 438,700 537,400 762,450 (1) Per Beth Israel memo dated 4/12/78. See Appendix G. The memo lists no amount for "Utilities", so a 3-month figure has been inserted. (2) Faculty positions at Harvard are by term appointments (usually of one to three years duration), and are contingent on continued availability of outside funding, Harvard has a responsibility to pay all faculty for 12 months after written notice of unavailability of outside salary support, which the industry may or may not wish to cover. (3) Unemployment insurance is an indirect cost covered by overhead charges under the agreement. Note: This schedule contains no provision for unrestricted payment of the unexpended clinical teaching and training funds. SsSoq4EQ

THE EFFECT OF PROGRAM TERMINATION'ON PROFESSIONAL STAFF DAVID DRATH, Ph.,D.,: Dr. Drath is a 35-year-old biochemist who was bornn in Brookl~yn,, New York, and educated at New.York University. An abrupt termination of the program will' adversely affect himiperhaps more than any other investigator., He has had to work very hard to achieve his education and to advance his.career.at Harvard. All of his research contributions have been, of superbly excellent quality, and he has established himself as an individual who can investigate comprehensively pathophysiologic mechanisms of tissue adaptation at the subcellular 1'evell. As a molecular biologist, the Tobacco and Health Research Program has provided himithe opportunity to apply the most basic scientific disciplines to relevant research goals. He is at a stage of'l~ife -and of' his,professional career where it is in his best interest to have his own biochemistry section. Within our overall program, he very capabLy adininisters his own section, and in that capacity!is the singular most dependable person in our group; regardless of t ' he:task asked of him„ he always comes through. Should the program continue, I wouldlanticipate that he would stay with us for several years tod come and then eventually move on to be a Professor of Biochemistry at aidifferent university. He has already developed his own research grant, which onifirst submission was approved but not funded. I would anticipate he will successfully:rai~se monies for our program and for himself from outside sources in the years to come., Should the program terminate, he most likely will be able to get a job somewhere, I am sure, but in a much more subservient and'less independentt role than he:has withus., In other words, it will be unlikely that he wi!1'1~ be able to move laterally and head up a research section of biochemistry in alcomparable administrative capacity, as there simply is not an abundance of these kinds of'opportunities. He has been an extremelry loyal and dedicated investigator to~the Tobacco Research Program, and shoul'd the p'rogram terminate every effort must be made to help him salvage his career. PAUL DAVIES, Ph.D.: Dr. Davies is a 32-year-old e1'ectronimicroscopiist who was born in Cardiff and educated at University Col'lege:of Swansealin Wales. We recruited him to our program from Switzerland, where he was working at the Anatomy Institute of Zurich,Uni.versity., He:is aniexcellent basic scientist, and has now established himself, through our program, as one of the few,stereolog,ists in the world. Like Dr. Drath, he iis a most capable administrator of his own seetion within our program andihas the responsibili~tyforall of the research investigati'onsinvolwing~,the structurall adaptations of the host. With his unique skills, he is an extremely: marketable commodity and!will have no difficulty obtaining,employment el:sewhere., It will be most difficult for him, however, to step~into a, comparable positi~on where he has the same degree of administrative responsi- bii]:i:ty:., In other words, like Dr., Drath, he will more than likely have to take a step downward in relocation elsewhere. He has an additional problem in that he is a Wellsh citizen, and is in this country on a year-to-year basis in terms of his visa continuation. Haruard has indicated to the immigration authorities that he is,essential to: our program, which he is, and on that basis will be abl'e to stay with,us, indefinitely. He may not achieve the same status elsewhere in this country, and may indeed have to relocate backk to Europe. His commitment to the Tobacco and Health Research Program has

been a total one. For example, when we had some difficulties with the ventilationiin the Annex and some of the technicians were unwilling to work with the smokzng, machines,, he personally went in and loaded animals himself,, and in so doing provided an example of leadership that others could follow. More than any other person in the program, he has the most realistic understanding of tobacco and health research issues, and a sensitivity to the industry's perspectives. He had workedl„ while in Switzerland, with the Leuchtenbergers and has the maturity and' discipline to provide outstand'ing, leadership in tobacco and health research in the years ahead. He would very much like to see the programipreserved, on the basis of'its scientific potential, and would like to remain iniBoston in his current capacity.. He will become a Professor of't#natomy sometime in the future, and should the program1be preserved he will benefit considerably. Conversely, it wil!1 be a significant set-back to his career if the program fails to go onward. Dr. Drath and Dr. Davies are the two essentia2 components for continuation of the research program. Through their efforts, we can develop precise quantitative assessments of the biologic effects of'' tobacco onithe host, as well as an understanding of the mechanisms of'interacti'on of tobacco with the lung. Both investigators are essential components in our animal research program, and'both have plans tolextend!their work to man in several different areas. Both of them have the maturity and capability to run major components of the program, to a considerable degree by themselves. Should the program be terminated',, both of'themiwill experience a significant set- back in the progression of'thei:r academic careers. C ROBERT WEKER, M.S.: Mr. Weker is 34-year-oldi research chemist at the Harvard'School of Public Health. Under the tutelage of Dr. First and others,, he has become an important part of our researchiprogram, handling most of the day-to-day analytical tobacco chemistry requirements. He is an important component to our continuing onward with the program, in that his contributionss in tobacco chemistry compliment the biochemical and'morphological data generated by the biological scientists. Should the program terminate, Mr. Weker will most readily be placed el'sewhere without difficulty,; as he is a most attractive candidate in a relatively junior positioni. He has no administrative responsibility and he willi be able to move laterally or upward elsewhere without difficulty. MELVIN FIRST, Sc.D.: Dr. First is now 64 years of age. He was born in Boston and has lived here all his lii.f e. He joined the Harvard School of' Public Health in 1947, and has remained there ever since. He is Professor of Environmental Health Engineering at Harvard. He,has~been committed to~ our program and has been a great source of administrative support throughout. His academic career will not be affected in any significant way be termination of the program, but the tobacco industry would loose an important person who has a good appreciation and understanding of many different problems that need, to be solved. He has been a most devoted andiloyal collaborator„ and has helped provide excellent leadership in all aspects of our program. MICHAELGOLDMAI+1, M.D'.,Ph.D~.:Dr. Goldman is, a 42-year-o~ldl physiologist. who has been at the Harvard School of Public Health since 11972'. He was educated at Harvard College, the University of Pennsylvania, and the Harvard . School of Public Health. As a research physiologist, he has beeniour primary link to extending many of our studies to humans, and inithat capacity he is a very desirabl'e resource in any eontinued!effort. Dr. Goldtnan''s appointment and salary are not dependent on the Tobacco and HealthiResearch C.7 ~ G!1' O'

Program, and should it terminate, his career will not be adversely effected., Like Dr., First, he has given to our pro.gramifar beyond that for which he iss paid'or supported, and he has been a valuable asset. C G. CLINTON SORNBERGER'., Ph.D.: Dr. Sornberger is a 37-year-old biostatiticiani. He was born in P'rovidence, Rhode Island, and educated at Holy Cross in Massachusetts and Catholic University in Washington, D'.C. Beforejoining our program, he was an Associate Professor of Mathematics and Statistics. In, addition to serving as our biostati:cian, he has been our theoreticianlin the development of'our stereology program. Furthermore, more than any other investigator on our staff,, he has taken on muchimore than his share of'f ad'ministrative responsibilities. If the program is to remain 1'arge,, he is an essential component. Should1the program be continued on a reduced scale, however, he would have a very limited function iniour overall efforts. We have supported him in obtaining,an additional, graduate degree in epiidemiology, with the anticipation that hewouldihea~d up ourstud'ieson human investigationsrel'ated to tobaccoland heaLthiresearch questions inithe future. He is in the process of developing,suchistudies at this time;' related to patternss of human smoking behavior and lung,funciton. He is at the stage of his career where he wants to have more managerial responsibility, and should' the program continue in i'ts full capaciity,, he would achieve this as the person primarily responsible:for human epidemiollogic studies. Should the program abruptly terminate, he, as a.biostati'.ci~an, would'have considerable opportunity for lateral movement. This more than likely,, however, mightt involve his relocating to a different part of'the country, for the greatest opportunities for people of his particular talents are in government programs in the Washington-Bethesda area!. He has built his own home in Worcester, andias the opportunities.for him to move on have arisen in the past,, he and his family have beenireluctant to explore them.because of their desire to remain in thi!s part of the country. More than any other member of our group.,, he probably has the greatest flexibility in vocational options.. MASANDO HAYASHI, M.D.,: Dr. Hayashii is a 57-year-old pathologist who was in the Department of Pathology at the Beth Israel Hospital prior to our coming here. By incorporating,him into our program, we obtained access to the electron microscope:and research laboratories in the Depart- ment of Pathology. He is not an overly productive investigator, but the quality of his research contributions has been excellient. The budget for his researchineeds is relatively modest, and if an effort on his behalf were expended,, there is a high probability that he could be almost ex- clusively supported by NIH funding. He falls into what our advisory committee has termedl"umbrella coverage,''' in that he more than likely would not survive at Harvard if he were not a component of someone eTse"s effort., Should the program terminate:, it will be most difficult for him, because of'his age, language barrier, and'li~.mited researchiproductiv3ty, to reTocate elsewhere. Should the program continue other than at the Beth Israel Hospital, it would seemireasonable to give him one year in which,to raise independently researehifunds for his own efforts, He has been loyal and devoted'to our program, but limited in his capacity., With his experiences and accomplishments in pathology, he is an asset to our applying for funding,from alternative sources. He has a son at Yale University and a daughter in college on the west coast,, and an abrupt termination of support for him will have a most significant Personal adverse effect on his life.,

WILLIAM CARSON HINDS, Sc.D'.: Dr. Hinds is a 39-year-o1d aerosol physicist employed as an Assistant Professor of Environmental Health and Engineering at the HarvardiSchool of Public Health. Dr. Hinds is a protege of'Dr. First, arndhas many of his attributes and characteristics. He has been very popular with the other investigators in our program, based primarily oni his always being willing,and available to solve a variety of different problems for the biologic investigators. His continued appointment at Harvard is totally dependent on the continuation of the HarvardiTobacco and Health Research Program. In fact, even wi:th continued support from our program, his future at Harvard is of considerable concern. He has not published or been as productive as he is capable of and,,perhaps equally as important, he has not been independently to raise research funding for his projects. At his age and his stage of his careet, he must demonstrate a higher level of achieve- ment in all of these areas in the next two or three years if he is to continue on the Harvard faculty. We are all making every effort to heip him in regard to all of'thi's, and it is uncertain how long, he can stay with the program if he is not successful with these endeavors. Thus,, as with Dr. Hayashi, Dr. H'inds falls into, the "umbrella, coverage," of the program overall. Should the program continue, he aliso would!have to be given a limited duration of support, beyond'which any continued, participation would be dependent onihis raising alternative sources of support for his related research efforts. The cessation of the program would abruptly end his career at Harvard!. He has reasonable options for employemnt by industry and,becauseof' hishi:ghly special!izedtra!ining and l~imited' university opportunities, perhaps slightly less reasonable options for employment as an aerosol' physicist in an academic envi:ronment.. C VIJAY MAHAJAN, M.D.: Dr. Mahajan was born in Punjab, India, and came to this country as a clinieal, pulmonary fellowattheC1eveland Cli!ni~c in: 1972. He jolned our program in 1975 as a research physiologist. He has been somewhat "'used" by the Department of'Medicine and the Beth Israel Hospital, for which he has considerable bitterness. He is a quality person,, and has been promoted'recently to the rank of Assistant Professor of Medicine. He has had several, job offers to be the head of aipulmonary section in another university, including one potential appointment at a higher academic rank with tenure. Should the Tobacco and Health Research Program conti:nue, he has considerable capacity to make many meaningful contributions in, applied1human research and, to a lesser degree, inibasic laboratory animal research. It would be desirable to have him remain with the program for several years, but it would perhaps be in his best interest to relocatee elsewhere as soon as feasi'bl!e. His future at Harvard is limited, whereas his future at a smaller, state-supported!universtiy is very bright. He wd.ll be encouraged to explore some of the options open to him at this time, which will be for him much more lucrative and muc3i more secure for his future. Hee will be a loss tolthe program, but should the program terminate abruptly it may be a blessing,inidiisguise and of considerable personal benefit to him, to relocate elsewhere. AM'I RUBIN, M'.D.:' Dr. Rubin is a 40-year-old faculty member at Rambam University in Haifa, Israel. He was brought to this country in coniunction with the Walewelski Memorial Lectureship, and i~s being,provided with clinical cj and researchitraining with the understanding that he will return to IsraeT. %:P He is a verytalented,, agressive, andihard-working,individual,,and is an. C1 asset to our research efforts. It was our expectations and' hope that, having OCD

been trained by us, he would return to Israel to supervise research investi- gations on tobacco andiheallth fromialiternate sources of fund'i:ng. Should thee program terminate abruptly, he and his family of four children would have to return to Israel, which: would be a disappointment and somewhat of ann embarassment to all parties concerned. Should the program continue, he shouldremain with us until September, 1979. If the program is to terminate, every effort should be made to help him return to Israel without undue personal financial loss. C ITZAK'GOLD'BE'RG, M.D.: Like Dr. Rubin, Dr. Goldberg is an Israeli citizen. Hecametoth,iscountryforreseareh,and clinical training and, after joining the atherosclerosis research,program at the Beth,IsraeT Hsopital, was, informed that his salarywould be$110~,00'0;/yearr. He applied tous, with tears in h3seyes, for additional support for his personal salary, as he was unable to provide adequate food and housing,for his wife and fi:ve children on his current salary, and because of his Israelii citizenship, could not be employed on a part-timebas~iselsewhere:inithis country as a physician. We are contributing $4500 per: year to his personal salary in return for which hee is providing,us with alpart-time research effort. He is an intelligent, excellent investigator, a very hard-working individual, and'has been very loyal to our efforts. Should the program terminate, he more than likely would have to return to Israel, with some embarassment to all parties concerned. MI,:CHAEL STEMERMAN, M. D:. ;, Dr. Stemerman . is the Chief of' the Thrombosis and Coagulation unit ot tne Beth Israel' Hosptiali. He was recruited'to this institution fromiMontefi:ore Hospital in rilew York„ with promises and' expectatiion that apparently could not be fully met after he arr:ived. For example, Departmental support for his salary was $10,000 less than was available. In return for his serving as a research consultant and collaborative investigator, we agreed, at the request of'the Department Chairman, to cover that portion of his salary. He has been most grateful,, and has done everything possible to repay our investment in him. He has been a great asset in the development of our current programiinvestigat3ng the mechanisms of atherogenesis in experimental animals, and we wouldlhope that he would continue to participate in a comparable role in the future. Should the program end abruptly, his position within the hospital might be slightly compromised relative to salary support„ but we can assume that the institu- tion has an obligation to him to meet that commitment:, He will not be adversely affected'by termination of'the program. On the other hand,, if there is any means of preserving his participation in our overall effort, his contribution far out-weighs our expenditures on his behalf. 0TTO' GRUBNEK, Sc.Di.: Dr. Grubner is a 54-year-old research associate at the Harvard School of Public Health. He was born in Prague, Czechoslovakia. In that country, he became the leading scientist at the Institute of Physical Chemistry in the Czechoslovakian Academy of Science in Prague, and!was the assistant to their Nobel laureate.in his field. For a variety of reasons, he had to flee that country in 1968, when he came under Dr. First's supervision at the Harvard Schooll of Public Health. He is regard'edias a fairly eminent ~ analytical chemist in this country and is on the Editoriall Board of the W leading chromatography journals. He is truly a displaced person, and has had some difficulty in adjusting to life in this country. He is totally ~ supported at this time by the Tobacco and Health Research Program, and O d

C shouid'the program terminate, it will most severely affect his academic career. He has the technical and research skilllis for relocation elsewhere, particularly in industry, but appears to need some degree of help on a personal basis by someone like Dr. First. He truly falls within the "umbrella coverage" of the program, but provides us with an excellent analytical chemist of the highest quality and with research productivity that is above scientific question. He is an asset to the program, perhaps even somewhat of a"'Iuxury," andi will have a most difficult time relocating elsewhere. TSUNETARO SAKUARI, M.D.: Dr. Sakuari is a researchifellow with Dr. Walter Abel!mann in the Department of'Medicine at Harvard. He is studying the effects of smoking on card'iovascular functi:on in man, both with non- invasive techniques (echocardiography) and with cardiac cartherization.. His research is unique andihis contributions wilil be most sigmificant. Although our salary expenditure is exclusively for him„ what we are really obtaini:ng,by supporting him is the continued participation of Walter Abelmann. Dr.,Abelmann is an 57-year-o1dIProfessor of'Mediclne at Harvard who was bornlim,Frankfurt, Germany andiwas educated at Harvard College and the University of Rochester. Dr. Abelmann is an Established Investigator in the American Heart Association, was head of'the Cardiology Unit at the Boston City Hospital and has achieved national, eminence in almost every capacity in academic cardiology in this country. In the early phases of the program, when we were struggling through the turmoil with the relocation fromiBoston City Hospital, Dr. AbeSmann volunteered his help with research efforts. Although we have never supported him directly, through his fellows and research associates, several contributions in cardiology have been made. Dr. Abelmann has been a most loyal collaborator throughout, and a dependable ally to the Tobacco and Health Research Program at various times of need. Should'the program be terminatedi„ Dr. Abelmann will not be affected directly in any adverse way, but the industry and'the researchh program will lose an extremely important and'valuable friend. Should the program terminate, we can anticipate that Dr. Abelmann will be able to find alternative support for Dr. Sakuari, but only with considerable diiifficulty.. JOHN SHEA„ M.S.: Special consideration should be given to Mr. Shea. Mr. Shealjoined our research program as a laboratory technician,. He obtained his graduate degree in microbiology from the University o'f'Massachusetts,, and'has been able to undertake relatively independent research throughout his years of participationion our behalf. He has presented a number of papers to national scientific programs, and made several meaningful contri- butions to our overaTl' research efforts. We anticipate that Mr. Shea will go on to conti:nue his research graduate education, perhaps in association within the program if it is to continue. He has givenia great d'eal' tolmeet our needs over the years, sometimes at considerable personal sacrifice. He has been promotedito Research Associate within the program, and should thee project terminate, every effort should be made to support Mr. Shea in his transition to graduate school'.