Tobacco Documents Online

•e TENTATIVE OUTLINE TOBACCO Sl`IOKING AND PULMONARY DISEASE I. Introduction II. Background: Morbidity and Mortality A. Tobacco Smoking and Lung Disease 1. Epidemiologic Data 2. Experimental Data ~ B. Trends in Tobacco Consumption C. Economic Impact of Tobacco and Lung Disease III. Non-Neoplastic Bronchopulmonary Disease A. Smoking and the Natural' History of Chronic Obstructive Lung Disease B. Smoking and the Pathogenesis of Lung Damage 11. Proteolytic Lung Damage 2. Interference with Immune Mechanisms 3. Effect of Smoking on Clearance Mechanisms C. Interaction of Smoking with Other Risk Factors for Lung Disease 1. Alpha-l-Antieypsin Deficiency 2. Socioeconomic Factors ~ ~3. Childhood Respiratory Illness D. Constitutional Susceptibility to Smoking and Lung Disease r 1. Genetic Factors 2. Behavioral Susceptibility O .. IV. Tobacco Smoking and Lung Cancer ~" A. Trends in Lung Cancer Mortality ~ 1. Epidemiologic Data

2. Animal Studies B. Dose-Response Relationships C. Lung Cancer in Women D. Lung Cancer and Cessation of Smoking E. Animal Studies:Relevance and Perspective V. Tobacco Smoking and Other Pulmonary Health Factors A. Allergy and Immunity B. Interaction of Tobacco SmokV With Pharmacologic Agents VI. Tobacco Smoking and Enviormental Factors A. Occupational Exposure 1. Asbestos 2. Uranium Mining 3. Nickel 4. Chloromethyl Ethers 5. Other (Coal Worker's Pneumoconiosis, et cetera) B. Air Pollution VII. Passive Tobacco Smoking in the Non-Smoker A. Constituents of Tobacco Smoke and Their Absorption 1. Carbon Monoxide 2. Nilcotine ~ 3'. Other B'. Biologic Effects of Tobacco Smoker on the Non-Smoker VIII. Other Forms of Tobacco Use and Lung Disease ~ M. A. Pipe and Cigar Smoking C~ C.^ B. Snuff and Chewing Tobacco ~ IX. Behavior and Cigarette Smoking A. How and' Why People Smoke:Effect on the Development of Lung Disease

A, W.. B. Establishment, Maintenance and' Cessation of Tobacco Smoking C. 'fodification of Smoking Behavior X. The Commercial Tobacco Cigarette A. Constituents of Tobacco Smoke . Trends in Product Delivery XI. Conclusions and Perspectives XII. Summary ,a

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