Tobacco Documents Online

9 e Y ~~nF': ~.~_',+n1,4~~ A fxve-yaur rse2 c` p eSraa to b s p_n e3 bY spersor_i:~; . H22'J2r.?+ ',M°_~Hcal ScP_^Ol! D:"OJOseS i,0ee-Vci.O- and i-71e:T»tit a ~BC?~~eT7~t,1I1CZ>>y~. otilvc.ci.i4-e 2Z...searChpror-,:cI1'Yel'ativL'tC)sf:,..271~ jL:G,l W'~ T"ikl LLl::S08_Vl pZVV'•luli rMyl~ia solu'''i,ion ors0:'.=:of i.^:- QLtc:s-t1oru T'2^,a:ai'`.'-Z cirarc^.u n S y-'tL'LiP- pri?iCi.pd 1.ni~esw~$2.'ii>'_~ r _~r ' T'll t~1'~ 1i.:aiZli~ti,7' e~ ~'ei~~E-'~_c O ari~'' ? grity cormarable to, that of Dr. nub:r -iR1 bc selec•cLd by tr.°., hP_iyu:: Y°d 1c21 School. 1fL° spons0'.".iPz co'ain'1~_ sL'_ppOZ'i, s'_7P_t1 be co=i'GirZ2ntuDon their 2; ?rovi=ij . Y?ly' sLc.^h sClb3iti~.~~S'iP.a pr_nC"?.paZ 121- yes'~i` a't-0r. - , . . 2. i'?i-_ desi~gn' aali' c:on:.uc t oi' t7he res::axcYi willl be exclusively the ri-rn'. nd obl igation of i:''-e principrap znves tigd i or 2r_d all resea?>caers cill be free to publ'is'~ results a* d' d.ata develoYed~ in the reseerch pro_rart atsuch •i•irres and in such scien`ci.fzzic f ou_r-zi-els as they may ele ct, tobacco comparies is proposed on •~.he fcla'c~n~ besis;, ].. Direct responsibil!ii,y for ~,e cetielop ~n ~n~ 2d-Tdris- tration of t,'h° pro~ran ;;11 be in the 2•'edic~J! Scnool''.' IJ.•. 'G2ry L. H'4 r rrilil bc tie princi ~_-1 aL-::.'-ar. i'irs. Frzn?;zin I~Fstein' 'Ed'FaI iH. K2ss and S. co tl'r2m C=~? pr04'1"~ e OvJ-'sJ'!'y Essistance as projeet consultants. In :~ie cveri'u Dr. Yiu~_cr bcecm•_..s vnav2.il.able prior t'o the co.-_:~letion' of ',~is xt:.search program, a sLb- 3. ar-=re presently ex:ists at F'4•r•v z: d 1'edi c?l School un8er i;'ne' direction of Gany L. Huber, princira3 investiSator, a We31- estab? ishad pz'G.-ra-t for tt~e irn•es-Gi.-ation o` factors that raa;yy be i:.eortant in ',.h= development of ti2r`ens ciseas=_s aad: host dei'en3es to such disnas=s, i ncluuinZ particularly 2:ost def enses to pulr.on-_yy ciseases. The prcposed~ progra-m on tobacco researeh v,-111 generally proceed alor.o the' follo> i four phases. (a) Xrze'1iav: lltili2'c.ii,lon, Ie:arc^ctloni . c7nCj' 1 oi`~kJl_T?i'ta'tt.'~On of exi s tinr resotLrces of ti:e alrez.dy esL t,lish~d prorram in order to study possible biolc~,ic effects of cigatti.'tt^_ upon i;i,e lu^.,; ti•ri uz •i:ne ob jectiive of rici. ^unina -},2ie role, if any, that ci,C,er-ot-Ff sr. ,' z-_ ru.::y plc:y i*i =~s_ develop:.a, t. of pu1=nsy diocasE. (b) Rapid ex'pansi.on of exis;,iz.Z reUources •;.o incluue a P i

H~:r 4~~ ~alr?'~~. p:,JPCS `~..~~ Pz~:e 2 • LfiJrc Cn.^tr?i?-^ns11'2 endeavor in 2rc?;:.is of (1.)bioc.l.2i::.3 s tZ'-j' f (11) Ti)ni`{'_Jlcoy, apd, (i.ii)) et'ide^=ol.^.~y, Ty'l8t?Ve i.o' Ciues-i.i.ons of hezli:~-' a~na cigar: tte (c) ~velcy^ ~ nt of linLt; 3 reso r s for i:-rie s17~-Ia-y o'~ po 4entia_l x<a a.tioxl.:a:ps b-Ci7r.,en sn' car:c_r of -tiL lur'g. (d'), Tr`vvelopmJntof eff orts, zndep-?ndently or in collabora- tioI6 YJJ .i.'_^_ o tLier pri v3,-e rese2_TCh f acili"Gie3, to S t'10. y PJSs7_fJl'C: • r.ti.latioPY'P.i7s bat:;_en cij£,'rc"Uts °=-1:P e.1T d' SL?2.-'"'G2ne. . •1.°.•cale.r diseases. 4. Z1Pe buC:~,e~for iif:?procZ•aid isoQt fo3'ii-}6~'~h attached. It is p tsentlly antici; at-3 wha p y,. ~,ats ;,-Ul be It'.cc;lveCZ in eCL1?= s.^- e`i2.TLlLal- iSlGtall ra~ritS Cti:°1r t}:? wl.ve-;5~2r''-°r:LoC't Oi yi.hiS It:seaxchp;•o.nira-m ai.3 f,h2'u, 2~-rPo3`i•?or7n~nt of sucli ptiu.e:7t5 yfi1'i be maAeby the sL-oYlso-riR1o CO*'-)<.TLleo e=J_y'(.R^f:Sejt1-_s_ 5. For conx•eruence, t0hespor_sorirZ m-; arzies will designai,e a pr2's^.n Viit-}S ri^JPthe. P?'1nCir-. L'3ti'. CoCa"d 'Lh=on-ch wtiow~'wne com anics may co^rra.zic_',;e z-Ith a;.'-~.e p-tncipal iii- vestige-`„or, aes:Qc;,irz, FZl matters relatin.- to 'ae pro-gr;zm- ' 6. Tna co;--~nceTant date of the pnDject shall ba Sept:eml~r 1, 1S''l2, Sor the purpose of bud,,e•tinZ. h'o fL ^.ds in ex,cess of y 2U3,C0-0.04 v;hicti Zlavenot been eY-pe_*'.d°_C'i or St?~C1i 1L•c~ 1~ cor-.::^_I-1.~.°d . for L'Xf>_i+~!itVr; .. .. 8f12~-1 be Teii..~n^:d past the end of £my ii8c.^21y`t1r.I2'i Co;zLJLAi.:TiU.. eYcess. amount, 2ny SLC~1 funds ca.rrif?d fo2'.7::r"afr•v.^.li t;PriQ:' fiscO, .. year or years shall be included. If, at the end of a fiscal year, 't.?le amount oFfunds in, e:tC2sss of 'lw^t t f}gvre sh_ll, a', t7".° op tioli oi.Harvzr3 2.`_ediczl School!, be applied es a credit to the nerL fiscal year or sna11 be re tu_-~.v:d to the co:-zr3es. 7. It is con'sL:pla:ted that at least four a.ssoc:iate invesTi--a'lors (e.g., in bioe ~ rtiatry, patfclo_c•,y, p7hysio?.c,Ey an& epidnniol_o-,y), o1't=^-2ir scientific equivale nts, S,ilJl evc-nt-1as-l,v- t-:o aecr ~~ec~: i,o pa?•ti.. Czpa r in -LZis prooran, 2n1 that ade:ua`,,z, spec:<, for i:nai-r ect.it~i-ci;-s v1iil bc mzde availablc 1,2-,:_ro:gh ~-)*_iies p otiee:d by -t?2ds bcd-et wnd! . ut^er• :,; se. A descrip-ut-i of all: st r.^~ ~C con erix z~ - t{se~AdcCuacy o" scC1 :P ace shall be provi2.ed by t^.:! nc-pal inv_ ~: ~ator :o -ihe ccr.:2anies o:;c-~ a ycpJr. Ssch stat.-2•~~,nt s:~~11 aLr-o ir.c]:cacTc- a reFor,; 0:1i.til_ e:Cpei_1ait'~...TMo S:1CL. oi faad& ioa 't;C'.e FIti:CC•fiill` '{;"i0lV~!- perloC.,. Y r 1

P:O2CS'ti, r: Jlr~ FP;c3 H'hZVlicJ 1,LDIC:4L SC'ti00L, 1f t ~f ~ / . ~YL, t L Exec~u;,ive s 2 cTetary C~ mititee ~n R•s_ca^'. ^3 I~'veZop.~ nu Fran_din Fosiei.n, ;Sc.D. irec;or, Harvard ?:edi.cal. Boston Ci cy f;nspital Accep'ed : ti7I? TLlA' S0?r TOBACCO COP,r OP.ATIOI. 1603 West Hill Street 1{.,uizviile, Kentucl:y 1,0~01 LXGC=^E~ L?'17r~S -1i:COFAPC)RA1r.D ~ ' . 00 Avenue - 2Ie;7 ~o °k, ?'e•rr Yoi'r 1.0K020 . .: $,As ~hs ",hu:':Zei, ir:_i.caGeo, project cossts ara Rll ra:aes cont=_c~~~_>d r;Zl be c g~. ed in 'i`ti-o fLr~h_.a... _._ this oro~re•-.t es di?^yc =d by-the principZ in;•e_-ciualcr. A .6~2i.e=.-'nt . c£'ri: n~=n~„ i~nn i. ~'aci. 4r3Q.1• t'?. iP_c1L'Qc^-a 1iR i...}L.p2'inC1- p:Ll in:asti~a~o_^'s a.Z:ue-, report. , 9 . {~IVl-i:7 ~ =.1clL21' I'8f@Ti'ncee if3 LllQ ;e'`. 1 teilt¢9r2-'tio".3 8ndl ?,=.'nJvatlorls~" , any ei-J°il6'~-GureSs ch2,rEE,';;ble to Sllch 1..1..?R2. vT 11. _cL •:._G:i . . . _~_..1 ::..~v i-..: ~ . . _ _ _. . - ~ iGpl,EC?ni,s -C^.e p:^oj.ecv' lv.r_'lSI CZ.eS^vT'it:-~C'i an^ S^l~_1l'i C} Si17,Jk..ct . tAYo prior a7:jTY1'v'l by i~ho 1il-vestZi`;atcr 2I'itl (h:. S17;nso,^i i C6r'-1-'e's. Ey Gzr. _Hut r. ?:', D; Principal Investigata?' id Ciln LtJ Y'?3 ~.tl ~iit :S~ J:Y.C. ~ . ~ -i,~ ~__~ 200 Eat;; lr2nd Straet t.e,. X~rfi, 1ics; Yoz _~ 10JU7 r , . 4 f i

1CrY alar; Die:r YoiG:, ?^ _~ Yor_: J•G3L7 !,J_L..est e,,,., 2i0~:i~Ca--•~nZina2i'.'..~2 IAF:US & BYCT.-~r Ct? ~Ai'Y, INC. j.~.' i',-•. LTOj.JJa Cii~' ETv:a: OR~ati c.aiiL.v r. iZ aa By u1:`,~L UNITED STtiTiLS TOBACCO CO~iat;ijl' ~~ - 7.G~~~~Pi~t`nNm Ave..ue GreEimvlCh, Coenecticut T?^ +r• Yutk, 2i •,1 ~ar}: 1JJli