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HARVARD SMORING AND HEALTH RESEARCH PROGRAM - EXTENSION AGREEMENT In 1972, a commitment was made by the undersigned Grantors to provide funding for a-Smoking and Health Research Program de- veloped by Harvard Medical School. Pursuant to the provisions of the commitment, funding wouLd expire in 1977. However, the under- signed Grantors and Harvard Medical School wish to provide further funding of'the program for the three (3) academic years of July 1, 1977, through June 30, 1980, as follows: 1. Grantors shall provide additional monies in the aggregate principaL amount of One Million Nine Hundred Fifty-eight Thousand Two Hundred Ninety-three and No/1MDo11ars ($,1,958,293.00), to be applied to the Smokingiand HealthiResearch Program for direct costs only. A budget is attached as Appendix A. An additional sum of ten percent (10$)i of any semiannual payment made hereunder will be paid to Harvard Medical School as supplemental fund's not as project costs. if, in accordance with paragraph 1 of the original agree- ment, the sponsoring companies do not approve a substitute investi- gator, reasonable and necessary expenses required to terminate the work in progress in an orderly but expeditious manner shall be pay- able from project monies available or to be mad!e available during the current fiscal year. Any monies not required for such purpose shall be held for disposition as directed by the Grantors. 2. Harvard Medical School shall continue to be respon- sible for the project. This responsibility shall include providing or arranging,for adequate housing,, services and the like. Harvard Medical School shall determine the proportion of supplemental funds paid by Grantors that should be paid over to any other institution that may be providing for the project and shall pay such amount. 3. All equipment purchased with funds from either the original or the extended grant is and shalil be the exclusive property of the Grantors, as they determine their respective in- terests, and utiLization of such equipment sha11 be only for purposes of the Smoking and Health Research Program. 4. Harvar&Medical School shall cause financiali records to be maintai~ned'respecting all funds made available by Grantors. Said records shall be maintained consistent with generally accepted accounting principles and shall be made available for audit by Grantorsq accountants upon reasonable notice from Grantors. Harvard Medical School shall require similar records ('and access to them by r

, 0 Grantors' accountants) of any entity to which it disburses funds other than for the sole purchase of equipment and supplies. Grantors shall have a similar right to all records respecting any funds they make available for the present Smoking and Health Research Program. 5. The provisions of the 1972 Harvard Research Proposal Agreement, as amended hereby, shall continue to govern the extended Smoking and Health Research Program, including procedures and fundi~ng,. Im particular, no direct funds are to be expended without the approvaL of the principal investigator prior to the initiation of said expenditures. A copy of the original proposal is attached to and:incorporatedl:into this agreement by reference as Appendix B. This Extension Agreement shall be dated as of the date the last of the signatories hereto executes it. HARVARD MEDICAL SCHOOL DATE: DATE: DATE: February 9, 1977' February 9, 1977 February 9, 1977 By f-~ L--7 L. 01, k^:9 Princip~al Investigator I --`~ { `--c Executive Secretary, Committee on Research`•.and Development, Ha,rvard Medical School 11 Herrman L. BLumgart Professor of Medicine Harvard Medical School THE FOLLOWING ARE EXECUTING THESE PRESENTS AS "GRANTORS'": DATE: Fr8• 21, fq77 BROWN & WILLIAMSON TOBACCO CORPORATION By mp • Franklim H. Epqi.`ein, M.D. G-i%y7~tl?/~ / ~ -2- ,

DATE: r4f a S // / ? / / DATE : Z DATE: /~c /, : A e., l i t? Z14CET? -- ,~ 1t BY L-G~. ~ C^ L LRILLARD, A DIVISION OF LOEWS THEATRES, INC. By PHILIP MORRIS INCORPORATED B Y le R. J. REYNOLDS INDUSTRIiES, IiNC. ~ 1 gy : ' .7- - I tt;' ~ L ti L.-~l , UNITED STATES TOBACCO COMPANY By r . .