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C C HARVARD MEDICAL SCHOOL BETH ISRAEL HOSPITAL DEPARTMENT.OF MEDICIME DINl510N.OF REfP1RATORY DISEASES GARYL. HU~ER.M.D+, CMI[F June 13, 1977 William W. Shinn, Esquire Shook, Hardy & Bacon Mercantile Bank Tower 1101 V+a lnut Kansas City, Missouri 4106 Dear Bill, Msiline Add>etr: tETM ISRAEL NJSPITAL S]D l1RDOKLITIE AV.EVUE •OtTON„ MLSSACMUfETTi OY21! 49171 735-2391 Although this matter has been covered several, times in the past by David R. Hardy, would you please send me a letter, which I can transmit or foiward on to the Beth Israel Hospital' administration if necessary, authorilzing me, as the Principal', Investigator of the tobacco industry research funds, to do the following: 1) Designate auth ority to one of my Associate Research Investi- gators responsibility for approving, in my personal absence, direct cost expenditures against these funds, exclusive of expenditures for reno- vati,on (which must be, by the agreement, approved by both the Principal Investigator and the sponsors) and exclusive of expenditures for professional staff (approval, for which I reserve solely for myself)'. 2) Transfer of monies betweenithe budget categories submitted with the agreement (between categories for personnel, supplies, equipment, travel, et cetera), to serve the best interests of the project, as directed by the Principal Investigator. 3) Carry over from one year to the next direct cost monies in hand at Harvard in an amount not to exceed $20&,000, as stated inithe 1972 agreement. In regard to the last point, I woulld like specific permission to carry over any unspent monies from the first five-year funded agreement period into the first year of the ren eaal funded agreement period, transferring after September 1, 1977 any remaining funds from the currently-existing (1972-1977) direct cost account at Harvard (#60-092- 9006-2)' to the new (1977-1980)~ account at Harvard (#60-092=4717-2) established for direct project costs.

C WilliaTn W. Shinn, Esquire June 13, 1977 Page 2 In all of these matters, I will take full responsibilities for the expenditures of all tobacco industry funds towards meeting the goals and guidelines established in the original 1972 agreement and the 1977 renewal agreement between the industry and Harvard University. If I can be of any specific help in: clarifying this request, please do not hesitate to call me directly. My warmest personal regards and highest respect, Gary L. Hube , M.D., Chief Division of Respiratory Diseases GLH/ncb