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HARVARD MEDICAL SCHOOL ~~ BETH ISRAEL HOSPITAL DEPARTMENT OF MEDICINE DIVISION OF RESPIRATORY DISEASES GARY L. HUBER, M.D., CH1EF July 11, 1977 Arthur J. Stevens Vice President - General Counsel Lorillard 200 East 42nd Street New York, New York 10017 Dear Arthur, Mailing Address: BETH ISRAEL HOSPITAL a30.BROOKLINE AVENUE BOSTON, MASSACHUSETTS 02218 (617) 735-2391 I was most pleased and very pleasantly surprised to receive the - brief note from youon June 28, 1977, in regards to my opportunity to serve as Governor of the American College of Chest Physicians for the Commonwealth of Massachusetts. I have had an extraordinary number of honors, appointments and offices given to me over the past year or so by a number of different professional organizations. I am always probably the most surprised person of all, and I hesitate to take on these many responsibilities. I have governed my professional life, however, by a deep belief and firm committment to science, and'to the professional organizations that represent the scientific endeavors of the medical community. I often do not agree with many of the public statements or positions of these organizations, and at times have to do some considerable soul searching in order to affirm my continued participation, particularly when functioning in positions of respon- sibility. There are many instances when I simply want to throw up my hands and resign, but always return to the conviction that the best way to deal with matters that need to be changed is to be active in the organizations and provide the leadership for new growth and better understanding. As I have expressed to Bill Shinn and others in the industry on different occasions, and as I recently wrote to Curt Judge, I believe that this kind of recognition for me, as the Principal Investigator, and for other members of this staff as participants in the industry- sponsored Tobacco and Health Research Program at Harvard, is an important form or expression of acceptance for our efforts. As II have reminded'you on several occasions, I will always remember your comments to me when we first met in California, when you asked, in effect, "Why would you ever want to get into this problem?" The answer then, as it has been several times since, and is now, is that I believed at the time and still do that there is a lot of atrociously bad research in the area of tobacco and health that needs clarification. It has always

Arthur J. Stevens July 11, 1977 Page 2 been my hope that the kind of effort we have developed at Harvard, and I hope will be developed elsewhere, will provide the kind of compre- hensive approach needed to resolve many of the questions that continue to exist. I hope that our research results will be respected by our Sponsors in the tobacco industry on their scientific merit, and I hope that I and the rest of the Investigators in the program will continue to receive the respect and acceptance of the professional and scientific organizations to which our "research products" are "marketed," so to speak. I have expressed to I think most everyone on several occasion my respect for the criticism, as well as the support, that comes from~ Lorillard. You, Curt and Alex sometimes hit a little bit harder than others but always with good intentions. In this regards I also remember, probably not often enough, Curt Judge's "constructive guestioning"of how on earth I could do so many different things in my professional life, and were I not by doing too much compromising my role as the Principal Investigator in the program which you are sponsoring. I would agree with him that I probably could do a better job in any one area, if I were to exclude some of my other activities, but try to keep in perspective the "bottom line," in all of these matters. In other words, I think that it helps the Tobacco and Health Research Program that I continue to participate in many of these professional organizations. I will assure you, in addition, that I always am doing my best to meet the Industry's expectations of me in provi,ding leadership and direction for our Research Program. Of additional interest, I do not know if you have been informed that we were awarded the application to study the effect of carbon monoxide and nicotine in tobacco smoke on the pathogenesis of experi- mental atherosclerosis. This is a new animal-model in a program funded through the National Cancer Institute. They tol&us that there were an initial seventy-two potential awardees, and that we scored number one and, in their words, "off the scale" on the scientific review. I enclose that application for your interest in case Bill Shinn had not forwarded a copy on to the industry sponsors. Some of your research staff may be interested in this new and hopefully important application of the Lorillar&smoking machine, for which we have the very deepest of respect. We have written a sizeable number of scientific papers recently describing the use of the Lorillard machine, and I know that Bill Shinn will forward those on to you when they are published. Both the NCI and the lawyers in Kansas City (through the help of Peat, Marwick, Mitchell and Co.) have taken very respectable steps to assure that there will be no cross-funding of the research endeavors by the ,b- C11

r . Arthur J. Stevens July 1'1, 1977 P age 3 C Investigators in our program in areas of mutual interest but separate sponsorship. We have taken considerable personal abuse in~the way of criticism by the academic community, from time to time, for accepting tobacco industry research~funding. I have never agreed with any of that criticism and I think being award'ed this large grant from the National Cancer Institute, as well as the various offices and opportunities through~the different-professional organizations that have recently come my way, goes a long way to answer some of that criticism, not with words but with results. Thak you again for the very thoughtful letter. I hope all is going well with you. We are doing our best to live up to your expectations for good research, hard work and honest resolution of some difficult problems. My warmest personal regards an&highest respect always, C $Wy Gary L. Huber, M.D., Chief Division of Respiratory Diseases GLH/rncb Enclosure

R-i`CEIVED JUL 13 1911 A. J. STEVENS If