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C IIARVAItU UNLVL:RSI'I'Y . SCIIOOL OP PUBLIC HEALTH Dr. Bernard F. Trum Animal Research Center Harvard School of Public Health Building,II, G-9 665 Huntington Ave. Boston, MA 02115 665 Hundrrgton 4uenue Boston, ~Jblarrachurettt 02115 617-732-1164, . Gary Huber joins me in thanking you for your kindness in inspecting the animal facility at Charlesgate West and preparing a report of your findings for our guidance. .It is our desire to~renovate this building in such manner that it will fully meet Food and Drug Administration, NIH, and Dept. of Agriculture criteria and be eligible for certification should this , step become necessary. on our operations. In furtherance of this intention we have already removed the rab- bits and are planning to follow all of the recommendations contained in your memo of Oct. 13, 1977. In addition, c-:e rrish~ to take advan- tage of your offer to review our plans and provide continuing advice Nov. 19, 197b. protectiori, against vermin.and to follow the provisions of Para. 3.c .90, Animal Care, contained on page 51224 of the Federal Register of We are planning to improve the animal facilities further by instal- ling monolithic floors in*rooms housing animals, to provide separate quarentine and isolation rooms for pigeons and for rats, to con- t.nin feed, badrl.j,ng, 2.ndother supplies in unitized metal containers that are verminiproof and kept in a designated storage areaa out- side the animal rooms, to improve the structure to provide greater Q3'748638-:' KRESGE CENTER FOR ENVIRONMENTAL HEALTN DEPARTSSENT OFLNVIRONMENTAL F'IEALTfI SCIENCES Would these improvements, in your opinion, provide us with a facility that would meet every one's criteria? If not, would you kindly in- dicate to me what additional steps should be taken to make the struc- ture and its equipment and facilities of such quality that it will meet theabove cited criteria? As I indicated to you earlier today, we are facing an urgent need to define all of the improvements that will be required to make it possible for us to resume full use of the facility for long term chronic studies at the earliest possible date. Your assistance is greatly desired and very much needed. It has been aareed that I will be the individual who will represent the

Dr. Bernard F. Trum October 18, 1977 ' Page 2 interests of the Chiarlesgate you and the Animal Resources Melvin W. F'i rs , Sc.D. Professor c'L Environmental Health Engireering