Tobacco Documents Online

1'. 11 I C'F. I, ti~:'( 1( )T r, n. 1'o:I'jemo_to I•'iil'e F~on::.llr-.~Ieinarct D~;z:_QQ~ t4b~ r~1~3 . 19]_7- --- I have visited a res^arch facility (October.3, 1977) operated by the FISFFI (Dr. Melvin W. First group representati.ve) at Charles;rate West Rescarch haci liity, 6 Charle.sc_I.:te West, Postor., Massachusetts 02115. This group ohcrat-ed at the Bo..ton Ci.y IIo:~pita1i until recently and does resear-ch on effecj'F- oF smo'.-,e inhalati~on. They use rats and, pigeons alraost exclusively, although a few rabbits were on hand. The faci liit~% is a convcrted office ruid' storage area and, al- though at t'ie time of visit, was not satisfactory as an animal care facility, both troan the standpoint of aninral and hu-man health and safety and efficiency of care, iit could be made corapletely satisfactory. The chanr,,es recommended' were: 1. Improve ventilation in orf3er to provide adequate air chan~ins (10 to 12 per hour). 2. Do not recirculakea;rimall colony air. Make up air can be taken from the exhaus'•.: of space not used to house animals. 3. Although a single roornifor rats and a single room for pigeons may be adcqaate, the ccntrol of inEectieus diseases becoi-iies more difficult. The sNac~:• ].a?t~: een racl:s must provide the protestion thet ro.om di,;iciers would ordinari.ly provide. If the io~~nis are cr.o-Ohd, an incre-. •c in i.nfectious-. r;i^ewse must lie antici.pat-ed. Forr tlii s res.^.on, it -,tcul;~l be hrefcrabd'e to divide the space into as many rcn*ns as practical. 4. Inhalr.tion apparati '0I:ich wore bei_ng used are not adequate for tiie control of c::scasc. A rrcthod shculd he ~ ~ ~ ~

J fl nirr 1, t'i I, /` (hlrli•r ( 2 ) devised to sanitize or sterilize the eqpii};incnt c ft'er usc before it is used on other. „ni.mols. If i-his i.s not-t practical, then the number tested on unsanitized equipment should he reduced to the smallcst practical and a protocol of use dra:•:n up and followed N-:hich will assure that the same equipment is always uscdion the same animals in the same order of use. 5. 17ie floors should be repaired - the vinyl (tile)) floor now in, use is adequate provided' broken tiles are re- placed and the floors thoroughl_y cleaned and o:avedi. Dry cleaning of the floor is recommended with a routine disin- fection schedule (weekly) followed. 6. Cei_lings (tile) are satisfactory provided they are repaired and intact. 7. Walls are satisfactory provided they are intact. The wall-board surfaces do not need resurfaci>>g. A cleanable, hard surface paint should be applied to other surfaces. 8. A rack and cage washer is needed'to saniltize eq.iip- ment to the degree necessary for the control of contagion. This implies the equip:nent to heat, pwr p and discharge •r:,,ter which may be adequate, but was not checked'. For example, small two-inch sewer pipes below the point of connection, will cause a pressure back up through sinks and toilets above the point. 9. Racks may be hand'washed andidisinifected regularly witliout thL~ rack washer, since they doi not come in contact '::ith the animals. Therefore, a cage washer would be satisfactory although not as convenient. 10. Storage snace for faod, b^dding an' .. pi;ii2s ~._ provided outside the animal roo-ms. , The Animal Resources Center (III•iS); will provide a revie=:: et plans and advise further regarding the operation of this facility, © if requested. The facility is no•:: regarcieci as an "off-campus" opcratinn ann must comply with the rules for care of anihials :is approved ?-,y the Committee on Animals. ~ 0 ~ ~ ~ ~ ~ ~r? 04 gb~

1.i,..i:n ~ V- , j.,i I - . ~rlc1 , 17~ IIaving, been told of previous difficalti.es req=irnii::g aniinal health, I strongly rccommcnd thatt arrangemenls ho made to adcL a competent coinparative or veterinary patt:ologist to this research faci_li~tygroup. I must add a disclaimer to this report: The above recoraien- dations, i~f fo1loeed, should result in, a satisfactory facility for the research as indicated to me. It will he compar&Ule to facilities on campus, but it will not, however, meeit the rigid standards of the "Good' LQiboratoiry Practice Act" as re- quirad by the Food and Drug Administrationi. Bernard F. Trur.;, D. V.ri. BFT/es cc: Dr. Melvin V7. First f Dr. Arthur L. Lage Dr. Iiar.ry I•Y. Glass Col Edwin McNceen! Mr. Ralph H. Charlwood

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