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Subject: Meeting of Scientific Advisory Board of The Council for Tobacco Research March 14-16, 1973 - New York, N. Y. To: Industry Technical Committee From: Murray Senkus Present Representatives from The Council!for Tobacco Research Henry H. Ramm, President Robert C. Hbckett, Acting Scientific Director W. T. Hoyt, Executive Director V. F. Lisanti, Scientific Associate J. M. Brady, Associate Scientific Director J. H. Kreiisher, Associate Scientific Director Clayton G. Loosli, Professor, Uhiv. of Southern Calif. School of Medicine Frederic W. Nordsiek, Associate Scientific Director Members of Scientific Advisory Board, The Council for Tobacco Research Sheldon C. Sommers, Chairman - Prof., Columbia U. College of Physicians & Surgeons * William U. Gardner, M.D., Dept. of Anatomy, School of Medicine, YaLe University Howard B. Andervont, Sc,D:, Scientific Editor (,retired) The Journal of the N.C.I. Richard M. Bing, M.D., Professor, Univ. of Southern California School of Medicine McKeen Cattell, MID., Professor, Cornell University Medical College Arthur J. Furst, Professor, University of San,Francisco John P. Wyatt, Chairman, Dept. of Pathology, University of Manitoba Leon 0. Jacobson, M.D., Dean, Medical School, University of Chicago Robert J. Huebner, M.D., Viral Carcinogenesi's Branch, National Cancer Institute Hans Meier, D.V.M~, Staff Scientist, Jackson Laboratory - Bar Harbor, Maine Members of Industry Technical Committee Murray Senkus, Chairman Helmut Wakehami Incoming Chairman, May 1973' Guest Leonard S. Zahny Public Relations Counsel to Council for Tobacco Research * Upon his retirement from Yale on 7/1/73, he will be appointedlScientifi'c Director of CTR. I I

Meeting of Scientific A'dvisory Board of the CounciL for Tobacco Research March 14-16, 11973 - New York, N. Y. Page two A. CONSIDERATIONI OF APPLICATIONS FOR SCIE4ITIFIC:MERIT Thirty-four applications were approved on the basis of scientific merit. They are listed beloca under the various categories, giving first the name of the prineipali investigator, his affiliation, and title of the project. CANCER RESEARCH Baruj~Benacerraf, M.D., Harvard Medical School, Boston, Mass. "ControL of Specific Cellular and Humoral Immune Responses to Neopl'astie and Nbn-Neoplastic Tissues" Attallah Rappas, M.D., The Rockefeller University, New York "Tobacco Smoke: Effects on Detoxification Mechani!sms" Hans Meier, D.V.M., The Jackson Laboratory - Bar Harbor, Maine "7ncogenesis in the Rabbit: Genetic Susceptibility, Vertical Transmission of Virus and Environmental Iinfluences" Jbhn W. Parker, M.D:, University of S'outhern California School of Medicine, Los Angeles "Im.wune Suppression by Cigarette Smoke and,Chemical Carcinog,2ns" Wayne L. Ryan, Ph.D,, Univ. of Nebraska College of Medicine, Omaha, Nebraska "The 3', 51 Cyclic Monophosphate System in Carcinogenesis" Jack ChaLon, M.D., Albert Einstein College of Medicine, Bronx "Changes in Tracheobronchi~ai Cytology" Richard A. Lerner, M.D., Scripps Clinic and Research Foundation, LaJolila, Calif. "Studies on Persistent Viral Infection" CARDIOVASCULAR Richard J. Bing, M.D., Huntington Memorial Hospital, Pasadena, Calif. "Carbon Monoxide and Coronary Atherosclerosis Duane CL Wenzeli, Ph.DL, University of Kansas, Lawrence, Kansas: "Nicotine andCarbon Monoxide on Vascular LipidDisposition" Louis A. SoLoff, M.D., Temple University HealthiSciences Center, Philadelphia "Purification and Physiologic Significance of Lecithin Cholesterol A'cyL Transferase (LCAT) PULMO`7ARY PHYSIOLOGY Allen B. Cohen, MID., University of Caliifornia, San Francisco "Human Alveolar Macrophages and Emphysema" H. Hugh Fudenberg, M.DL, University of California, San,Francisco "Collagen Antibodies in Relation to the Etiology of Emphysema" .Joseph S. Guarneri, Ph.D., Long,Island Jewish-Hillside Medical Center, New Hyde Park, N. Y. "T~he Influence of Extended Exposure to Cigarette Smoke on Pulmonary Resistance to Infection as Related to Alveolar Macrophage and Mucociliiary Function"

C Meeting,ofi Scientific Advisory Board of the Council for Tobacco Research March 14-L6y 1973'- New York, N. Y. Page three C PULMONARY PHYSIOLOGY (continued) Jerome I. Kieinerman, M.D., St. Luke's Hospital, Cleveland',,r~hi,o "Experimental Emphysema: The Effects of Prolonged!Dust and Nitrogen Dioxide Exposure on the Physiologic and Morphometric Parameters of the Hamster Lung" Clayton G: Loosli~, M.D., University of Southern,Callifornia, Los Angeles "The Effects of Fresh, Cigarette Smoke Inhalation on the Respiratory Tract of Mice" James Travis, Ph.D., University of Georgia, Athens, Ga. "Biochemistry of Chronic Obstructuve Lung Disease" Domingo M. Aviadoy M6D., Univ. of Pennsylvania School of Medicine, Philadelphia "Influence of Cigarette Smoke oni Pulmonary Emphysema and Bronchospasm" Charles G. Cochrane, MID., Scripps Clinic & Research Foundation, LaJo11a, Calif. "The Mediation of Inflammatory Injury of Tissue" Martha P'. Greenwood, M.D., University of Kentucky, Lexington,, Ky. "A Study of the Functional Capacity of the Monocyte-Macrophage System" Joseph M. Lauweryns, M.D., Ph.D., University of Leuven, Belgium ' "The Lymphatics of the Lung. Their Role in Fluid Transport and Clearance of Airborne Particulate Matter in Normal and Experimental Conditions and in Various Lung Diseases" Robert C. Rosan, M.D., Cardinal Glennon Memorial Hospital for Children, St. Louis, Mo. "Molecular Parameters of Lobular Regeneration and Function" George 6Veinbaums Ph.D., Albert Einstein Medical Center, Philadelphia, Pa. "The Effect of Air-Borne Pollutants on Lung Proteinase: Antiproteinase Levels" EPIDEMIOLOGY Benjamin Bell,, M.D., V.A. Outpatient Clinic, Boston, Mass. "A Smoking Research Program in the Normative Aging Study" H. J., Eysenck, Ph.D., D.Sc.,, Institute of Psychiatry, London, "Inheritance of the Smoking Habit" Gary D. Friedman, M.D., M'.S., Kaiser Foundation Research Institute, Oakland, Calif. "Characteristics of Smokers and!Non-Smokers" PHARMACOLOGY B. Bhagat, Pn.Ds, St. Louis Univ. School of Medicine, Stl. Louis, Missouri "Effect of Chronic Administrationlof Nicotine and Smoking on Brain Biogenic Amines" CarltomK. Ericksony Ph.D., University of Kansas, Lawrence, Kansas "Effects of Nicotine on Free Acetyleholine in the Hippocampus During Learning" Leonide Goldstein, D:Sc., Nl. Ji. College of Medicine an&Dentistry, New Brunswick, N'_J. "Behavioral and:Electrophysiological Effects of the Chronic Nicotine State in~Rats"' t

C f Meeting of Scientific Advisory Board of the Council for Tobacco Research March 14-1i6y 1973 - New York, N. Y. Page four MI'SCELLANEOUS Thomas R. Dawber, M.D., Boston University MedicaL Center, Boston, Mass. "Smoking Classes, Risk Factors and'Cardiovascular Disease"' Walter B. Essmaa, M.D., Ph.D., Queens College of the City, Univ. of Npw York "Studies of Nicotine Action upon Memory ConsoLidation" Paul S. Larson, Ph.D., Medical College of Virginia, Richmond' "Abstracting and Classifying the Literature.on the Biological Effects of Tobacco and Preparation of Manuscript for Supplement to Tobacco (19$1). Ronald R. Hutchinson, Ph.D., Ka1'amazoo State Hospital, Michigan "The Blood'Pressure Redbctant Effects of Nicotine" Norman W. Heimstra„ Ph.D., University of South Dakota, Vercvillion, S. D. "Effects of Smoking Deprivation on Group Problem Solving Processes"' H. David Mosier, Jr., M.D., University of California, Irvine, Calif. "Effect of Nicotine on the Rat Fetus" B. APPROVAL OF GRANTS FOR INITIiATION OF'RESEARCH'BY GRANTEE It will be noted that at this meeting the Scientific Advisory Board (SAB) considered the grants for scientific merit only and approved or disapproved accordingly. Following each approval', each member of' the SAB rated the a lication relevance with res ect to the CTR ro ram. Majqr importance is ascribed to the following actors in estab- lishing re evance: (1) smoke inhalation research, (2) motivation for smoking, (3) epidemiology, (4) twin studies, (5) nitrosamines; and'.otlhers. The staff`at CTR will tabulate the ratimgs for the applications which had been approve 'on the basis of scientific merit a31d wilil then establish an order of preference for the "ha~_!~ rn rhe CTR n*n&r4m The E:cecutive Committee of the SAB will then approve the grants, the number of grants to be approved being dependent upon both (1) availability of funds, and (2) the preference ratings. Thus, it can be seen that some of the applications for grants may not be activated owing to unavailability of funds,,even though they may have been approved on the basis of scientific merit. C. CONTRACTS AT TEE ILLINOIS INSTITUTE OF TECHNOLOGY IL.SEARCH iNSTITLiE Two projects had been in progress at the Institute; these were: Riesen and Kyle. "Bioenergetic andlEndocrine Studies on Cigarette Snoke and Stress Relationships" Aranyi and Riiesen. "Effects of Tobacco Smoke on Pulmonary Alveolar Macrophages" Dr. Kreisher announced that these have been terminated. D. NEXT MEETING ~ The next semi-annual meeting of the Scientific Advisory Board wilil be held on ~ October 10-12, 1'973. ~ Cr. /has ~

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