Tobacco Documents Online

Tlm, GoUNciL P0R To BACCLdr•.,Vaizci[-ti.S.A., I.r-c. .' EXPENDITURES AGAINST 197.7BUDGET AND ESTIMATE FOR 1978 (In Thousands of Dollars) Tonic of Area of Research 1977 1978 Cancer Related 3',1i38 2,381 Respiracozy Associated 807 603 Heart and Circuliation~ 213' 1Z4' Pharmaco loa,.= 846 690 1 Immunology and Adaptation 192 30 Epidecliology 584 537 TOTAL 5,780 4,4154 Unassigned Balance as of October 31, 1977 , 130: 1,495*' TOTAL 5,9110 (5,910) #-This balance does not allow for inflationary increases. *-This figure will be used for (1) grants and contracts for which there is no implied commitment but which may merit continuation; and' (2)1extension of research support into new areas of investigation such as: (a) (b) (c) (d) research for nicotine binding,sites in the central nervous system; effects,of carbon monoxide on~pulmonary and vascular function; nitroso~compounds in tobacco and in cigarette smoke; and development of an aerosoli,zer that can deliver fresh smoke-si~zed particulates of some smoke components.

CASiCFIt =IES SUl'PORTED IN 1977 CANCFR AND POLYCYCLIC 614MICAL CARCINCGEVS CI.ARE'ClE UMC10:~ NIDICOOCOMi'OUfIDS VIRUSES AI1D CllVCER EFFECTS OF YITAMIN A AND -------- INII-RESPON".~ES ----- AROMATIC IIYDRCCARFinryy; - yron_PlJI Ctl~ Mouse rabblt mouse nbblt A[ULtt;I,F.; -M1nu1 Ij-iman- HUMAN STUDIES Mlaals ;.Y.udies MSxsl Studlen An1me1 Studles/:C ~- (iee Epl.demlologicnl Section) I. Pulmonnry C ctnoma Mouse I flliros 1 ea f~4 . . - S t v a k e Itieltto I , HS 1 1 wl F . f f t - h I . Tumo . Imminaloglc I . Met 1 Se I , Chemlcel C 1 o en I Popule.tlo tTtieli M~vlele C tica ' A) n Kt St PAII D1 (a] L~1 e I+eu 1 Rt al Gao- {g}-[~etectl AIM Icucoc n Fur L t, ntraet N +J11)• 2. Me (//922q) ~IM Canlract 22A/27A) 1 pulm n y C i g nesla I t ntrol nf transferasee Pet d--Lh m1en.1 1 M0. C ntrnct Na 2 A [All St c.. nc~ ~T~'Tn_~ Wo1f 10201Q) _ , . 2 (#1132) G tr i (b) Arcon (f/~22p) II. Ii-~~x11 s o" ldtnei. - _ ~ 1 Fxp .. lon - Le (N'JGCmt2M~ . g n a 3 11) (V ~- 1 G~- II. 9e k Conae t Yr tions Tc r (/(?b6HR2)e+ . . ,nv 935 4 R"co (K1.102) (c) MAI (C t e<t //]I5H) D[!A 9-p_ 1 Mut~$ ~esln ' ' ' (b) 'IT 1 ce tal Ff]cte_ - II, Role of M4c ophog_ (D) AHN 1 h6c .s/ n II. Re1nL1o hi t C et¢ome III. Asbest s Furst (COntract 9D)i R mv qry 9 y~) _etibSt Me1 rI~ 1a ) IL Sc tl ~~ t1c Ibt t nts (e} Cig tt ~o ke (mouee) N vltz (/1(V15:tu1) othe ti ; k N ~ k P - Ho t alna~ (b) Tr fo tt Mute- Ch mlcnl C 1« asu . mn nrn an- o e_rs n 1: C L1 AKK -~ sie F1D ~1 1 ~sin ' II, M_.~ ' g cofs I "C~ (b) "orml/A ti . ted 1. Martt I094) 2. C 4 11 (//1120) A C L c;: /{lliH) ~euedlcY~~l3C+c ~~ s) ContenL ln T D_co end J[evy FN C tract Nac Ohagea (c) 1Yneb. b onenin) 2. I d in_Clgarette fknokeYVrmatln ¢nd N28Gr t 41011A) U e(,'t10;0R1) Multi 1 ntion 9n k ' III CS~ tt :]wke end YAII Transler Jil) - Li-el (k107 M t b lis@ ' 14eurnth(1F91nR1) (b) l, ti 9 ptib111ty, (c) t (d) ~ (b) Epo Sd. It7drnta not AI II 1 dncers) i !1 uI 1ceu i W. and Mnc hng. S dueed ~oacAlm ~b945AR1) n -,ol r ennne, itttiy^ jd cie1en N 07~R1) -- GnHronmentai Innuenoen act n ---- (e) (k~co-teWne Eb reeaton rtlyatlon Su tr,Imci ot r T^I^nge (//la?:~t,l) pulmonery ca. . K of YAIi tAe.ie: (7511Cf2) _ 1. Plshmen 3 0esch (N1097) - (d) iMC Onhnge Depeodeot Cuirgln (~ 32) 1 boc tions . e~eac - (f) f netic SL dten- - (c) Genetles~ Xenctrople i{~V 1, F- ee vlth H1ph/Lox Ytrus AWf rophnL'ee E]'o a1°c Cnneer Ine(dences .mofif ' F:(, kContrnet 25) .. .. _- ... ) smokera~non-suuF.ere I -- yncb lA J. Iivy {a1011A) h'3rtln ((/10~~,) 2. Glucuronldnee Genetic b ndd C , (d) AIHi: [IMu; 1>emet lese IlI. SL. r Ce11e te ^ Pa1g N1080R3) -- Arros . nln c ~ iDI,OHl) YS (K) See>•etory C .t af I Ae ~ nP ~ 0 Maiker S Pu1an ~Cnrclnrnm _ (e) Me.t D ]tr t'roftlea 1Umor Site 34' .chonl 1 ]nv+aga f]u1d) - - ~. µ%nR (~1MihRl) ~ Response at ----Neynolde 41127) 2. Gfelen 17~107.'[tl) e in T' er~ Gal.eatosYl (h) tiesue) rcinaes e R'enaterner.n (f) (nhibltory Ef-Cects aP Ieim (Nyl~~y}) YoT - 191UR2) Iaothl0cynr_ - .._ . . . . ~iinie-rnberg (R1031R1) SII. N-o iaaclve Pnthvny (~1(y3 o:ymP .~FiyT~yniFet - rminatea 3/31 77 - erminnted G /30/77 sloane ~RZT , ofiszsyFo 6 I I 1 I

(ON f=. \ CARDIOVASCULAR STUDIES SUPPORTED IN 1977 fSee also - Epidemio3:ogdcal Section) a I $LOOD FLOW ART£RIOSCLEROSIS PLATEf~TS AN IOTENSIN I-IUN.AN STUDIES HUMAN STUDIES - ALLERGY SMOKING-CORONARY ffr''ART DISEASE (Smoke: Nicotine:CO) T}$20MBOSES - Epidemiological (Dog/Rat and Hu__man) (See Section on id.) a oronary Collateral -a Inhibition of (a) Endothelial ^eil and a ndocrine Function a Tobacco Allergens a Normative Aging Stu Blood Flow Cholesterol take Platelet Resonse to p of Lungs 1. Becker 10i0M)* Bosse' - ( 55D)- - 9noke: nicotine) Bing 310_AR2T SSno~ Cigarette Angiotension I-II _ 2. Gleich (#101l+A )*-- D owney (/}918R2)** Nicotine and C0. Ryan (,,Pl4AR2) (b) Kaiser-Permanente Study _ (b) Izcithin Cholesterol 1 Mason #939A) Characteristics of (b) Nicotine-Induced Ac ltransferase (2) Booyse (#1133M) Smokers- Non-Smokers Reflex Coionary - 0 519CR2) Friedman (#787DR1) Vaso ilation (Conscious Dog) (c) Tobacco Allergens - (c) Smoking-Coronary Heart Vatner (#974A) Arterioscleros is -and Disease (c) flicotine-Acute and ocardiai Infarction C. Seltzer (#885R1) Chronic on aggressio Becker 1010M and blood pressure reactions in rats (d) Endothelial Cells: and humans) Platelets. Hutchinson 41107) 1 Mason (#939A) (2) Booyse (#1133M) (d) Nicotine ( eri and postnat,, behavior and blood pressure in rats) Klaiber/Matalka 41095) (e) Fetal-N.aternal Effect Smoking Nrcotine and CO - (Monkey Manning ~#1139) ~ - T rminated 3/31/77 ** - T rminated 6/30/77 *** - T rminated 9/31/77 IVSZ99Eo 1 1

\ PUIMONARY STUDIES SUPPORTED IId 1977 p w ~MPHY`EMA/BRONCHI'PIS E_hiP_HySEh ~RONCHITIS £NVIItONMEPTTAL SPECIAL MORPHOLOGICAL IMMUf'iE MECHANI`R+~.S itivtt : r n i PUItAONARY -FUCCROYHA~:>; STUDIES RDS In€lanao.:tion RDS In43ammation (G-igarette 9noke) Speci~-Fhnetions of y se jype s -- Allergy lliseases Diseases _ Lg Chronic Bronchitis) Gontinuedl - I.-Protcases: anti roteases-r-- - -- I. Human StudiPS I. Neuroepithe2tal Bodies I_. Tobacco~catigen I. hmmlt~slogical I ~104jTTi1) ( a Human e idemiolo . se - IV. Leukocyte Elast - - Iii F stories ~nokin a ~ Lauwer yns i,'10r~11R1) 1. Gleich (~~]074P)+~-ir. 1. Herscowitz ~ - d1A'P phenotypes ~ Gom lement Interac±ions 1 - ~AT-~~diseases -- '.. Becker (/11010M}w ~. Mnrt_in (~/309~f) 1. Buist (/rr1044R1) Tchevotacti.call active 1. Hu~ t (`~1o44R1) II. APUD Cells 2. Evans (~1043R1) fractions of C5). 2. Evans (j/1 .0h3R 1) will /;]C36R].) II. Mucous Membranes II. Pro-teases rd (/{1105) Crawfo _ __ - secretoryi7rnnune system) 1. Travis (#1135) (b) Mechanisms Biochemistry __ - - ) 9noking-Lu~ Ftrnction Studies (b III. Endocrine Functions Larmn (i914R2_)K~* 2. Weinbauni (k'901bff22) leucocytes. macrophat ;es V. Pancreatic Elastase _ 1. Adolescents ASgiotension I-II) 3. Michaeli (#9b1R2) _ collagen~ elastin) CireulatTnglevels Hnmosh,P. (#1108) Rya_n (f/fi14A1;21 4. Turino (#10i34R11- 1. Cohen (/L954B) (AL4 mthod): human 2. Adults 2. Feinstein (/11033R1) smokers, normals, gsumsh'P. (#878R2(s))** IV. Goblet Cells III. Contractile Proteases: - 3• :7avls/Powers (•'1ll3S) bition diseases. Inhi Reid- 3D82) Plasma Membr ane -- 4. Weinbnum (j/901N822) _ in vitrofdlAP levels). (c)hloTpholorical Hiochemical ~ ~ H) - Geokas (~103 - - Reid-1 ~ 2 Stosse3 ?126) . (~ . (c)Mechartlsms: Biochem and _ ---- - . Lhtic Inhibitors 2 (d)Elastase Activities . owers (if ll 35 -- PMN macrophages ~ _ _ Turino l1084R1) (d)I:cperimentnl sev.a: - Lung Lesions rats ZZ. Animal Studies - 3:- WelTbama ~''9C1MR2)*-* s Mor~hological and Metabolic Geokas (~1088,' (~hosphol1pids:blu~factc+nt:-- _ biochemistry) (e)Ci [irette 4heoke 1. Cross (#937R.'-)* Tycozom;il enzytne release) . K. Iinmosh (1/93GR2M)"* Cross (#937R2)* 3. blp,arette Snokc on Feta.l and Postnnta'r,unDevel - I. Other Prcteuse Actions vent and Metnbolism Rat £ibrinolytic system: M. k{nmosh #:330) platelets/col]aCenj - * _ TER-MENA'£ED - 3/31/77 1. Cochrane (F764F) ~ - TkIUQNATEU - b/30/77 Hiachemi cal 0 (b) 2. trlchaeli (~/9b1R2) ~* - 9/3 / TERh11NA'PED 0 77 pr eolytic ~rrzymes: s) vasoactivo amine . Tissue Destruction by Ptoteases _ Micho~eli (t/961R2) -macrop nges-- --------- - Turino i084 - (// Rl) I I II i ?:VSZ99Cn I, I Ti 1 I

101 n r PSYCHOPHARMACOLOGY AND YHPRMACOLOGICAL STUDIES SUPPORTED LN 1977 HUMAN STUDIES ANIMAL STUDIES ANIMAL STUDIES ANIMAL STUI)IF,S RiA FCR NICfITINE (Cigarette Smoking) - Yie~~ioral Metabolic (Nicotine Receptors and AND M1;TABOLITES (a) -Behnviornl Effecta on 1. Genetics I. Non ';rnocers of Exposure Heredity: Tobacco Related to ^noY.ing Behavior (mouse) - Heims~a (#10b1R1) (#1076R1) McClearn (b) CNS Adrenergic Functioning 1I. Nicotine (Piperidine) ana -?makinp (a) Rehaviorn.i Effects of Klaiber 1f1003At!)" Nicotine and Piperi.dine_ (c)Ph¢rmacokinetlcs of U(nts-) _ _ Abood (j{9!?3R2) IIc-M•s: 3nokinC and Cessation -- - Jue. cd ( il1079ku ) (d) See Ly~idemiolodical Sect.ion Genetiz=~:nvironment_n_1f¢ctors-smoking b-.hzvicr Crumpncker (#3066R1; (b) Di.^,crireinntive Stimulue Pro11-crt,ies of Nicotine and Relate_d C_ompou_r:ds-- ~rats~ Rosecrnns 0909A) (c) Nicotine (aggc'ession and blood pressure- - r nt ) tiutchinson (//1107) (d) Nicotinc (peri and -__n_nt- nl) pont Behavior and blood pressure (rats) Klaiber andMntoQka (#1095) "" - Termi4ted - 6/30/77 CV;zsyCO Nicotine a c~.ons of nicotine on Serv_m Pancreatic 'lastnse ~.eyels: dogFT- Geokas (~f10f3B) (b) Absorption Bucca] Absor ti~n)(cai..9) Turner** Netnboiism oE idines" Gorrod -)t -R2 - II. Tobacco S1moke Niooti.ne/CO n CO-Tobacco 2noke on Retinul-Metn"boI-sm and FSinrtion cat rnbbit__ Ingenito IOl5A (b) Metabolic Response to Stress-Tobacco Smoke Interaction mnuse rats) A;ssman (1f1138) (c)Actton qn Aectylcnolinq Rrvria ~ Sastry ~ (It~7119A) (d)Nicotinc/CO effects on Amino Acid Transport Tnto7lrnin mnd Protein Metabaliam. RnT- Lajtha (jJ3d4i) _ Binding Sites) I. Central Nicotine Receptors a Abood (~7Y%3R2)---- - (b) Schmidt (//105f3) 2. Neural Tissue Rece tors - Gcnetics 1?rosophila Melan aster Mutsnts) fiall 112 _ Huuna.n Placenta Reuna Sastry (/{9_49A) 4. Uterus (rat) Yoshlnaga (//1042R1) I. Devel mentsl a Ni_cotineZand ,F~et;ab~ft~s) in Blood Detection by RIA 1. Castro (/,!tS,'MM) 2. McKennis (1,11054R1) 1

^ MISCELLANEOUS STUDIES SUPPORTED IN 1977 /'1 REPRODUCTION IMMUNOLOGY (See Cancer Studies) I. Human - - I. Basic Studies Smoking T aT a Biology of Suppressor-T Fetal Postnatal) Cells Kullander (Grant #1039R1) Pierce (#1040R1) (b) Nicotine Effects (b) Normal and Activated (Human Placenta 1. Damage: Kullander(#3039F1) 2. AcetylcholineSystem: Macr hages - Unanue #1030R1) II.Chemicai Carcinogens Rama Sastry (~~~`J`+9A) II.Animal Izmnunological Competence (mouse) Lerner (#766BR2)*'* a Nicotine: CO (Cell Cleavage: III. Macr h e implantation: gestation) (a Cigarette Smoke (mouse) 1. Mitchell (#]A12R1) 2. Yoshinaga (#1042R1) Herscowitz~#1045MR1) (b) Induced Factors: Cancer immunit (b) Nicotine Ta]_mage -1086R1) Slood pressure/behavior (c) Normal-Activated in rats) Klaiber and Matalka Unanue ( 1030R1) (d) Smokers/Non-_Smokers f#1095) (human (Macrophage dependent lymphocyte reactions) Martin (#1094) IV. Tumor Site Lung carcinoma (human): Ioachim (#945ARi) vvS?:99cn n ^ ** -. Terminated 6/30/77

^ EPIDEMIOIAGICAL STUDIES SUPPORTED IN 1 (Health Disease Mortality: Relation to S.oking Environmental) SMOKING: NON-TWIN STUDIES I. Behavioral: n (b) Kaiser Permanente Twin (a) Genetic-environmental Registry Feasibility Study factors-Smoking behavior: Friedman (#985R15) Crumpacker 30 l (See McClearn- #1076R1) (c) Finnish Twin R~e istry (mouse)) (b ) Smoking Motives, Rantasalo (#953MR2) Personality and -We33-Being -- Cc--ta - 10 5Ri- II. Characteristics of Smokers/Non- ( ) Genetic-Environmental Smokers and Ex-Smokers Factors-Smoking Friedman 7DR3 Behavior Crumpacker (#1066Rl) ~ III.Health: Aging: Disease (See Friberg (a) above) SVS299Eo (b) Smoking-Coronary Artery (See McClearn-#1076R1 (mouse)) (f) Susceptibility Index for Disease Lung--anAHH and Seltzer (#885R1) immunochemical mothers CEA AFP (c) Effect of Smoking on --Guirgis (#1132) Health and Aging Bosse' 55D) SMOKING: TWIN STUDIES (a) Swedish Twin Registry Friberg A136) (See Crumpacker (e) below) PROTEASES: ANTIPROTEASES (See Pulmonary Studies) I. dlAT Phenotypes: - Lun runction aBuist 1044R3) b Evans (#lo43R1) ^ CANCER Fam~li-e-swith High Low Cancer Incidences (a Lynch 19r- Part I (b) Guirgis (#1i32) (c) Rasco (#1102)