Tobacco Documents Online

CURRENT STATUS OF CTR' S CO6ISIDERA T ION OF MICROBIOLOGICAL ASSOCIATES CONTRACT PROPOSALS Following the visit by the SAB Task Force and staff to.Bethesda regarding status of Microbiological to MA with regard to the MA proposals for the contract SAB and staff, CTR has now proposed the following action Associates (MA) contract and later discussions betweenn year Juliy 1, 1978 through,June 30, 1i979: CTR would like to continue, subject to• using smoking machines, whole animals and vari- ous types of reference cigarettes and BaP. (ii) Studies of possible presence of ,X certain so-called biochemical markers, using live animals, whole smoke and RaP. (iii) Studies to develop', a model which receiving from MA appropriate protocols and contract,, the inhalation work, using various strains of mice, whole smoke, and whole smoke together with~BaP'. In this con- . will include the use of aerosolized chemicals. ~. The aim,of this model is to evaluate particle deposition. 40== C ~ ~ ~ ~ . ` ~ Q~ _ .

(iv) In vitro studies to develop model assays to evaluate possible promotional features (ii) Studies of biochemical markers such as oDC, aimed at testing the possible promotional' r,. effects of whole cigarette smoke condensate and ;~ - its various fractions. (iii) Certain initiation 3t.idies, especially those using,DI3A damage assays. 4.' n (iv)' Studies aimed~at de~e^tion and quan- titation of possible carcinogenic metabolites in mouse urine as a lead to bladder cancer. (v) Whole smoke experiments testing the immune system's prevention of lung!eancer and the susceptibility to lung cancer as alfunction of age. (vi) In the area of so-called 10initiation" studies, studies aimed at evaluating the initiating capacity of whole cigarette smoke condensate and its ~ . - various fractions by variations of Ames-type tests.

;(Y) In the area of short term tests, studies comparing the potential of whole ciiga- ~ - services to other CTR grantees iin the following areas: - ~ (ii) Also in the area of short term D ~ rette smoke condensate to induce DNA'damage. . F tests, studies aimed at testing the pbssible mutagenicity, etc. of cigarette smoke conden- I (iiii) Any appropriate studiz!s that re- I searchers would propose relating, Y;bladder cancer cancer causation. _ CTR'will continue to contract with MA for MA will continue to„~rovid'e smoked Rasmussen for his study of DNA re- . Herscowitz for his evaluation cf possible im- munosuppress3've effects of cigarettr- smoke. -3r t r O

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