Statement of Henry Rothschild, M.D., Ph.D.
Date: 16 Mar 1982 (est.)
Length: 4 pages
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Length: 4 pages
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- Rothschild, H.
- SPCH, SPEECH/PRESENTATION
- BIBL, BIBLIOGRAPHY
- LEGAL DEPT FILE ROOM
- Named Organization
- NCI, Natl Cancer Inst
- Named Person
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- 07 Jan 1999
- Master ID
- 03607523-8364 Comprehensive Smoking Prevention Education Act of 810000 Hearing Before the Committee on Labor and Human Resources United States Senate Ninety-Seventh Congress Second Session on S. 1929
- 03607531-7540 97th Congress 1st Session S. 1929 to Amend the Public Health Service Act and the Federal Cigarette Labeling and Advertising Act to Increase the Availability to the American Public of Information on the Health Consequences of Smoking and Thereby Improve Informed Choice, and for Other Purposes.
- 03607587-7594 National Institute on Drug Abuse Technical Review on Cigarette Smoking As An Addiction
- 03607618-7620 Coaliion on Smoking or Health Seeks to Influence Legislators
- 03607621-7623 Coalition on Smoking or Health .. A Public Policy Project with the National Interagency Council on Smoking and Health
- 03607624-7626 Former Ftc Counsel to Staff Coalition on Smoking or Health
- 03607627-7629 Statement of the American Lung Association to the House Subcommittee on Health and the Environment on H.R. 5653, the Comprehensive Smoking Prevention Education Act
- 03607630-7636 the Importance of the Federal Government in the Prevention of Smoking Related Diseases Testimony in Support of H.R. 5653, A Revised Version of H.R. 4957 the Comprehensive Smoking Prevention Education Act by the American Lung Association
- 03607681-7692 Lung Cancer, Coronary Heart Disease and Smoking
- 03607717-7724 Statement on S. 1929 'comprehensive Smoking Prevention Education Act of 810000' of Dan G. Mcnamara, M.D., F.A.C.C. President to Honorable Orrin G. Hatch Chairman Committee on Labor and Human Resources
- 03607725-7726 File No. 792-3204
- 03607727-7730 Statement of the American Medical Association to the Labor and Human Resources Committee U.S. Senate Re: S. 1929 Comprehensive Smoking Prevention Education Act
- 03607731-7734 Statement on S. 1929 the Comprehensive Smoking Prevention Education Act of 810000 by John R. Walton, Rrt President
- 03607735-7740 Statement of the American College of Physicians on S. 1929, the 'comprehensive Smoking Prevention Education Act of 810000'
- 03607741-7749 Testimony of the American College of Chest Physicians Submitted by Thomas L Petty, M.D., F.C.C.P. President Regarding S. 1929 'the Comprehensive Smoking Prevention Education Act of 820000'
- 03607750-7751 Testimony of Action on Smoking and Health (Ash), by Its Executive Director and Chief Counsel, John F, Banzhaf III, Before the Senate Committee on Labor and Human Resources, Chaired by the Honorable Orrin G. Hatch, on the Comprehfnsive Smoking Prevention Education Act (S. 1929) Submitted 820402
- 03607752-7763 Federal Trade Commission Staff Report on the Cigarette Advertising Investigation
- 03607764-7770 Statement of the Bakery, Confectionery & Tobacco Workers International Union to the Senate Committee on Labor and Human Resources Re: S. 1929 'the Comprehensive Smoking Prevention Education Act of 820000
- 03607771-7790 Comments on H.R. 4957 - - Proposed 'comprehensive Smoking Prevention Education Act of 810000'
- 03607791-7793 Cigarette Smoking of Pregnant Women
- 03607794-7809 Peter L. Berger
- 03607810-7813 Gilgamesh on the Washington Shuttle
- 03607814-7848 Statement Rodger L. Bick, M.D.
- 03607849-7854 Statement of Theodore H. Blau Ph.D. Presented Before Subcommittee on Health and the Environment House of Representatives
- 03607855-7858 Statement of Walter M. Booker, Ph.D.
- 03607859-7864 Statment Smoking and Fetal Growth
- 03607865-7873 Curriculum Vitae Oliver Gilbert Brooke
- 03607874-7884 Statement of Barbara B. Brown, Ph.D.
- 03607885-7892 Statement of Dr. Victor Buhler
- 03607893-7896 Statement of Jack Matthews Farris, M.D.
- 03607897-7909 Statement of Sherwin J. Feinhandler, Ph.D.
- 03607910-7936 Statement of Edwin R. Fisher, M.D.
- 03607937-7945 Statement of H. Russell Fisher, M.D.
- 03607946-7979 Statement of Jean D. Gibbons
- 03607980-7983 Statement of Katherine Mcdermott Herrold, M.D.
- 03607984-7997 Statement of Arthur Furst, Ph.D.
- 03607998-8015 Statement of Richard J, Hickey, Ph.D.
- 03608016-8021 Statement of Duncan Hutcheon, M.D., D.Phil. Departments of Pharmacology and Medicine 820312
- 03608022-8053 Statement of Leon O. Jacobson
- 03608054-8065 State Ment of Lawrence L, Kupper, Ph.D.
- 03608066-8085 Statement of Hiram Thomas Langston M.D. Clinical Professor of Surgery (Emeritus) Northwestern University Medical School
- 03608086-8091 the Alleged Cost of Cigarette Smoke
- 03608092-8121 Statement of Eleanor J. Macdonald Professor Emeritus of Epidemiology Department of Cancer Prevention University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute, Houston, Texas
- 03608122-8129 Statement of John E. O'toole, Chairman, Foote, Cone & Belding Communications, Inc.
- 03608130-8166 Statement by L.G.S. Rao, Ph.D. Bellshill Maternity Hospital Bellshill, Scotland, U.K. Regarding H.R. 4957 S. 1929
- 03608177-8190 Statement of Bernice C. Sachs, M.D., Seattle, Washington
- 03608191-8195 Concerning the 'comprehensive Smoking Prevention Act of 820000'
- 03608205-8236 Statement of Sheldon C. Sommers, M.D.
- 03608237-8246 Statement Professor T.D. Sterling
- 03608247-8275 Statement of Professor Yoram J. Wind for Submission to the Subcommittee on Health and the Environment
- 03608276-8277 for Use at 10 A.M. Tuesday, 820316
- 03608278-8287 Statement of Robert Casad Hockett
- 03608288-8317 Relationships Between Family Smoking Habits, Individual Differences in Personality, and the Smoking Behavior of College Students
- 03608318-8337 Personality and Smoking Behavior
- 03608338-8364 on the Relation Between Family Smoking Habits and the Smoking Behavior of College Students
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646 Statement of Henry Rothschild, M.D., Ph.D. Introduction I am Henry Rothschild, a medical doctor and doctor of philosophy specializing in genetics, molecular biology and oncology, currently Professor of Medicine and Anatomy at the School of Medicine, Louisiana State University, New Orleans, .i Louisiana. Since 1962 I have been engaged in research involving the genetic basis of ` disease and am director of the Louisiana Ethnogenetic Disease Association. I currently serve as consultant to the Louisiana Department of Health and Human Resources and am a member of the Research Committee of the American :' Heart Association of Louisiana. I have published over 40 scientific articles. My Curriculum Vitae and list of publications are attached. Discussion Studies conducted in Louisiana have demonstrated an unusual distribution of ; lung cancer mortality. The lung cancer mortality in white males in Louisiana is the highest in the nation, and in particular the 27 southern preponderantly rural ~ parishes ranked in the top 3% nationally from 1950 through 1976 and has risen since - then. Studies that I have been conducting since 1975 on this population indicate 4 that genetic factors may play a significant role in this excess mortality from lung u cancer. In our initial investigation we interviewed the next-of-kin of 284 of the 813 persons who died of lung cancer during 1971 through 1977 in the 10 southern, nonurban parishes. We found that 108 (38%) of the decedents had been employ for at least six months as sugarcane-farm workers at some time during their lives and that the relative risk estimate of lung cancer mortality for sugarcane-farni , workers was more than twice that of the controls. Neither employment in other ,- industries nor tobacco consumption could account for the elevated risk of lung~ < cancer mortality associated wi We then began to exp including a group from the Na there may be "an inherited prec :here are genetic factors assc found, for example, that first- .ng cancer have higher rates c 'actors such as age, sex, birth c non-smoking first-degree rel. `ourfold risk of dying of lur i oKuhata and Lillienfield, 19( :~creased risk of lung cancer rr ~Fraumeni, et al., 1975) The argument for the pot( ~t al., 1974) is supported by re ~.ffer in their incidences for s, saectrum of different genetic ':stribution curve of genetic sus Studies of distribution o -aport this proposition. Comp ' oidly accelerating incidence c ':exican and Chinese extraction I+e a higher incidence, and A =wer incidence. Chinese in F ' ~e^ocarcinoma of the lung, a _~^iamaric, 1969). !n analyzying our data we "^ponent for lung cancer in th, 0 W ~ ~ ~ N j
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647 schild, Y.D., Ph.D. ion >r and doctor of philosophy specializing , currently Professor of Medicine and ;iana State University, New Orleans, !search involving the genetic basis of nogenetic Disease Association. : Louisiana Department of Health and Research Committee of the American blistied over 40 scientific articles. My attached. ion iemonstrated an unusual distribution of -tality in white males in Louisiana is the the 27 southern preponderantly rural m 1950 through 1976 and has risen since since 1975 on this population indicate : role in this excess mortality from lung .ewed the next-of-kin of 284 of the 815 1971 through 1977 in the 10 southern, ?6) of the decedents had been employed workers at some time during their lives ig cancer mortality for sugarcane-farm controls. Neither employment in other ! account for the elevated risk of lung cancer mortality associated with sugarcane farming. We then began to explore the thesis expressed by many investigators including a group from the National Cancer Institute (Goffman, et al.,, 1982) that there may be "an inherited predisposition to lung cancer." Studies have shown that there are genetic factors associated with lung cancer pathogenesis. It has been found, for example, that first-degree relatives of individuals diagnosed as having lung cancer have higher rates of lung cancer that cannot be accounted for by other factors such as age, sex, birth cohort, or cigarette smoking. It was also shown that a non-smoking first-degree relative of an individual with lung cancer has about a fourfold risk of dying of lung cancer when compared to control relatives. (Tokuhata and Lillienfield, 1963, Tokuhata, 1964) A similar study reported an increased risk of lung cancer mortality in siblings of individuals with lung cancer (Fraumeni, et al., 1975) The argument for the potential genetic regulation of tumor incidence (Bodeau et al., 1974) is supported by results of studies indicating that many mouse strains differ in their incidences for specific tumor types (Murphy, 1966). In humans, a spectrum of different genetic predispositions for each tumor implies that a distribution curve of genetic susceptibilities exists for each tumor (Reif, 1981). Studies of distribution of cancer among different ethnic groups further support this proposition. Compared with whites, for example, blacks have a more rapidly accelerating incidence of lung cancer in the United States, Americans of Mexican and Chinese extraction (Buell et al., 1968; Fraumeni and Mason, 1974) also have a higher incidence, and American Indians (Creagan and Fraumeni, 1972) a lower incidence. Chinese in Hong Kong have an unusually high prevalence of adenocarcinoma of the lung, a relatively infrequent cell type in other areas (Belamaric, 1969). In analyzying our data we obtained results that establish a strong genetic component for lung cancer in the Louisiana population. (Ooi et al., 1981). Of the
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648 446 white residents of the target parishes who died of lung cancer during 1976- 1979, we interviewed the next-of-kin of 328 cases. Of the 328 case families, 54 (16.5%) had first-degree relatives with lung cancer, compared with 16 (5.3%) in 304 control families. There were 61 (2.2%) lung cancers among the 2767 case first- degree relatives, compared with 18 (0.8%) in 2389 control relatives. This aggregation of lung cancer could not be attributed to differences in age at death, family size, or mortality. Six (1.8%) of the case families had two or more first- degree relatives with lung cancer. First-degree relatives of persons with lung cancer had, therefore, a lung cancer risk more than twice that of control relatives. Comparing case and control relatives by stepwise logistic regression indicated that a person's relationship to the person with lung cancer, and the square of a person's age, are the two strongest predictors of lung cancer outcome, even after controlling for the effects of age and sex. . We are in the process of further investigating this population to attempt to ascertain whether any major genes can be isolated as being involved in the pathogenesis of lung cancer. If we can isolate such genes, it will be major step forward in unravelling the mystery of lung cancer causation. t Henry Roth hild, M.D., Ph.D. Belamaric J: Cance Bodeau P, de Saint- Buell PE, Mendez W Creagan ET, Fraume Fraumeni JF Jr, Mw Fraumeni JF, Wertei Goffman TE, Hassinl %lurphy ED: Charact Ooi WL, Rothschild 1- Reif AE: OncoloAy I Tokuhata GK: Am J. Tokuhata GK, Lilienf
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who died of lung cancer during 1976- cases. Of the 328 case families, 54 :ancer, compared with 16 (5.3%) in 304 ; cancers among the 2767 case first- 6) in 2389 control relatives. This ibuted to differences in age at death, case families had two or more first- egree relatives of persons with lung e than twice that of control relatives. es by stepwise logistic regression :erson with lung cancer, and the square dictors of lung cancer outcome, even :x. tigating this population to attempt to e isolated as being involved in the ate such genes, it will be major step 649 Literature Cited ' Belamaric J: Cancer 4:560-573, 1969 Bodeau P, de Saint-Maur P, Herreman G, et al: Sem Hop Paris 50:1161-1168, 1974. Buell PE, Mendez WM, Dunn JE Jr: Cancer 22: 186-190, 1968. Creagan ET, Fraumeni JF Jr: 3 Natl Cancer Inst. 49:959-967, 1972. Fraumeni JF Jr, Mason TJ: J Natl Cancer Inst 52:659-665, 1974. Fraumeni JF, Wertelecki W, Blattner WA, et al: Am J\4ed 59:145-151, 1975. Goffman TE, Hassinger DD, ltulvihill JJ: JAMA 247: 1020-1023, 1982. Murphy ED: Characteristics of tumors: Ingreen (ed), Biology of the Laboratory Ooi WL, Rothschild H, Chen VW, et al: Clin Res 29:862A, 1981. Reif AE: Oncolog y 38:76-85, 1981. Tokuhata GK: Am J. Epidemiol. 89:139-153, 1964. Tokuhata GK, Lilienfeld AM: J Natl Cancer Inst 30:289-312, 1963.