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501 STATEMENT OF LEON 0. JACOBSON 19 I am Leon Orris Jacobson from The University of Chicago in Chicago where I continue as a physician-scientist emeritus and have served as Chairman of Medicine, Dean of `fedicine 3n3 Biology and Director of the Argonne Cancer Research Hospital. In February 1942 I became responsible for the medical safety of the personnel of the Metallurgical Laboratory (the atomic bomb project) under the direction of Arthur Obmpton, Norman Hillherry, Enrico Fermi, Leon Szilard and many others who achieved the first self-sustaining chain reaction. Iater I served as Associate Director and then Director of Medicine and biology of this enormously successful national program that brought the war abruotly to an end and in the aftermath provided the tectnology and the radioisotope tracers so enormously important to the revolutionary advances in biologv and medicine that contribute an ever increasing momentum to cur un3erstan3ing of normal as well as disease processes. I joined the Scientific Advisory Board of the Tobacco Industry Research Committee (now called the Council for Tobacco Research - U.S.A. , Inc. ) in 1954 when it was under the leadership of Clarence Cook Little. Dr. Little aooeared before (bngressional committees dealing with smoking an3 health in 1955 and 1969. The mandate of the Scientific Advisory 9oar3 was broad 3nd simple, namely to sponsor independent research in

502 the area of tobacco and health. The Scientific Advisory Board ras and is today composed of individual scientists whose expertise covers those disciplines of the biomedical sciences that are essential to understanding the complexities of chronic diseases and their pathogenesis. In spite of the successful elimination of many diseises caused by infectious agents, we are still groping for an unierstanding of th e inexorabl e proces s o f chroni c d iseases such as arteriosclerosis and cancer. Are we in any better position today to fathom the challenging puzzle of caise and cure of these devastating medical problems? ae are becoming more aware of the fact that cancer, arteriosclerosis, and other chronic diseases are not the result of exposure to a single substance that has been inhaled or eaten. For example, arteriosclerosis is hastened by a concomitant hypertension, but occurs even in peoole who are of normal weight and without hypertension. What causes the arteriosclerosis that leads to coronary occlusions and strokes? Here we have a controversy that will be resolved only when each of the categories of research unravels the cascade of events that leads to death or disability. It would be disastrous, for example, to decide now that arteriosclerosis is primarily a problem relating to blood lipi3 control. Cancer etiology and control have been intensively researched, especially in the past 75 years. We have learned much from the rapidly developing area of molecular biology - 2- 503 which is driving us nearer and nearer understanding the thousand and one cor membranes, within cells and in organs required for maintaining the normal s' beginning to understand the interrela cells, tissues and organs such as the adrenals as well as the brain itself. constituents is not an independently f rather part o f a wonderful organism wc I healthy individual which quite often r abnormalities (or copying mistakes) t} `_rorc injury or disease. Spontaneous s cell division are inevitable because r yield exact copies of the genetic infc t- neir progeny. The body has the abil: of genetic material in which a mistake reoroduction process. If the repair i t~en the newly formed cell might die c a new kind of cell - a cancer cell. Fiow else might cancer occur? We k can be inbred in a deliberate way (by an3 a predictable percentage of their =sncer. This is a very useful laborat carcinogenicity or cocarcinogenicity o other agent. Likewise, epidemiologist =losely observing human "cancer famil i - 3-

which is driving us nearer and nearer to the ultimate goal of understanding the thousand and one continuous reactions in cell membranes, within cells and in organs and tissues that are required for maintaining the normal steady state. We are just beginning to understand the interrelationships of individual cells, tissues and organs such as the lung, kidney, and adrenals as well as the brain itself. Each of these body constituents is not an independently functioning entity, but rather part of a wonderful organism working in harmony in the healthy individual which quite often reverses or corrects abnormalities (or copying mistakes) that result spontanously or from injury or disease. Soontaneous mistakes in the process of cell division are inevitable because millions of cells must yield exact copies of the genetic information they possess to their progeny. The body has the ability to reoair the strands of genetic material in which a mistake occurred in the reproduction process. If the reoair is incomplete or fails then the newly formed cell might die or it may go on to develop a new kind of cell - a cancer cell. Ebw else might cancer occur? We know that selected mice canbe inbred in a deliberate way (by 20 generation crosses) and a predictable percentage of their progeny will develop cancer. This is a very useful laboratory tec`lnique for testing carcinogenicity or cocarcinogenicity of a given chemical or other agent. Likewise, epidemiologists have found and are closely observing human "cancer famil ies" in which the genetic

role is clear. Thus, a full understanding of the complex process of carcinogenesis must consider not only abnormal inherited genes or chemical expceure of the genetic material of a cell but also the possible imaact, involvement or participation of ionizing radiations and ultraviolet rays, viruses and many internal derangements. In the laboratory animal, when studying tucor induction with a given chemical substance or virus, one has better control of the various factors which may play a role in carcinogenesis, but inhumanepidemiological studies it is very difficult to isolate one factor from another. Human beings are exposed to a variety of environmental impingements. They also have d i ffering l i fe s tyles i nvolving v3rious s tres ses, eating habits, drinking or smoking habits, as well as different genetic or constitutional backgrounds. We are seeking ways and there are promising leads in the search for the members o`_ our population who may be susceptible or likely to develop cancer. We have found families with genetically transmitted susceptibility to emphysema. Likewise in the field of cancer, we are now looking for markers to identify peoole who might be susceotible. Whl have I stressed the importance of soontaneous, inherited or induced genetic aberration in the development of disease? SimpLy because many of our dread diseases seem to originate after a lesion occurs in a DNA strand, which may actually lead to the development of an individual cancer or -4 - become an inherited problem in successi• example, molecular biology has already 1 sequence in the double helix responsible anemia. Genetic engineering is a thing promises rapid progress. Malignant cells carry unique and ide their surfaces that are characteristic a malignancy. With current techniques imm Killer 'P lymphocytes that recognize and e molecules of malignant cells and destroy attacking the surface molecules of the ta Many have heard of the hybridoma - a revolutionizing biology. In the test tub tumor cells and antibofly-forming cells re that can generate, perhaps immortally, la a:lt1bo31°_s that will react with small pep part of a large protein. These hybridoma be used to treat tumors. This is an exam engineering can and is doing. We shali sE in fact, we are alrea9y witness to a genetic engineering procedures. ^cven as I stand here at age 70, I am Y 3ee the answers before the end of this cer. aiseases that pLague us. We are in the mi `-rsitfui fields of molecular genetics. We 3`-Z7raalities and we can even splice in ne -5-

become an inherited problem in successive generations. For example, molecular biology has already located the particular sequence in the double helix responsible for sickle cell anemia. Genetic engineering is a thing of the present that promises rapid progress. Malignant cells carry unique and identifying molecules on their surfaces that are characteristic of the specific malignancy. With current techniques immunologists can develop Killer P lymphocytes that recognize and seek out the specific molecules of malignant cells and destroy the malignancy by attacking the surface molecules of the target malignant ce11s. Many have heard of the hybridoma - a powerful tool that is revolutionizing biology. In the test tube a fusion o f mouse tumor cells and antibody-forming cells results in a hybrid cell that can generate, perhaps immortally, large quantities of antibodies that will react with small pepti3P chains that are a part of a large protein. 'Eaese hybridoma antibodies may also be used to treat tumors. This is an example of what genetic engineering can and is doing. We sha11 see in the next decade, 3n'9, in fact, we are already witness to a wide spectrum of genetic engineering procedures. Even as I stand here at age 70, Z am hopeful that we shall see the answers before the end of this century to many of the diseases that plague us. We are in the mid9le of vast and fruitful fields of moleailar genetics. We can find the genetic •5normalities and we can even solice in new gers segments. We

507 are literally swimming in new knowledge in immunology and only beginning to ap?ly the fruits of these discoveries. This has been a remarkable era of discovery in the area of peptide hormones which exert tremendous influence on many functions, including lung and cardiovascular. The future challenge is to see whether, and how, these peptides say play a role in the causation of chronic disease. From these continuousLy ®erging discoveries, only a few of which I have touched upon today, the synthesis of disparate ` findings occurs. It is this synthesis whichheral3s the understanding of the aging process. Only such understanding will lead to control of our most formidable and complicated diseases such as arteriosclerosis, heart diseases and cancer, as well as the whole category of other degenerative maladies. LEON ORRIS JACO Born December 16, 1911, in Sims, 1 Tiarried; tvo children, Eric and Ji Degrees: B.S., 1935, North Dakota H.D., 1939, The Universit Honorary Degree of Docto: 2torth Dakota.Stata Unive- Honorary Degree of Docto: Acadia University, Nova : Licensure and Certification: State of.Illinois :i Anerican Board of Iaterai -`acadenic. Eositioasi5;=' ihe IIniversitv o'f Chicastc Intern, 1939-40 Assistant Resident in ISee Assistant in.Hedicine, IS ; - Instructor in Medicine, i Assistant Professor of Hc Associate Dean, Division Sciences, 1945-51 Associate Professor of Hc Professor of Medicine anc Section, 1951-61 Professor and Chairman,.I 1961-65 . Joseph Regenstein Profes: Tledical Sciences, 1965- 8 Dean, Division of the Bic the Prit:ker School of Ttc 0 W 0 0 ~i 0-82--33

- - Sha Uiri-versity of Chicago latera, 1939-40 Medicine Assistant Resident in Medicine, 1940-41 Assistant ia.Medicine, 1941-42 Instructor in Mediciae, 1942-45 Assistant Professor of Medicine, 1945-48 Associate Dean, Division of the Biological 'Sciences, 1945-51 Associate Professor of Medicine, 1948-51 Professor of Medicine and Mead of the Deoatology Section, 1951-61 Professor aod Chalrman,.Department of Medicine, 1961-65 Born Deceaber 16, 1911, in Sims, North Dakota Married; tvo children, Eric and Judith Degrees: B.S., 1935, North Dakota State University M.D., 1939, The University of_Chicago Bonorary Degree of Doctor of Science, 1966, ;' North Dakota. Stata University Bonorary Degree of Doctor of Science, 1972, Acadia University, Nova Scotia Licensure and Certification: State of I1linoia - Amaricaa Board of Internal `Acadenie ~ -7 Joseph Regenstein Professor of Biological and Medical Sciences, 1965- 81 Emeritus 1981 - Dean,- Division of the Biological Sciences and the Pritzker School of Medicine, 1966-1975

Health Officer, Metallurgical Laboratory (Plutoaiun Project),,Sianlxattan District, Medicine and Biology, 1942-43 Consultant, Division of Biological and Medical Research, Argonne National Laboratory Special Cansultant, Bematology Study Section, U.S. Public Health Service, 1949-63 Consultant, Division of Radiobiological Health, University Grant and Training Branch, Department of Health, Education, and Welfare, 1962-65 Consultant, University of•California, xerkeley, 1962- E1SdC'1lSl`S~LIK~hII(iIXf S 4~'f KllfofdX IEdi1'S~,KXI~GD:X K21L`SXI.}$~( ~1(fX NlkVU!` YYdAXKXQRW Boards and Committees: Associate Director of Health, Metallurgical Laboratory (Plutonium Project), Manhattan District, 1943-45 Director of Health, Metallurgical Laboratory (Plutonium Project), Manhattan District, 1945-46 Member, Institute of Radiobiology and Biophysics, 1949-54 Director, Argoaai Cancer Research Hospital (operated by The University of•Chicago for the U.S. Atomic . 'Energy Commission), 1951-67 Director,.Franklia.McLean Memorial Research Institute :'(opara.Lad_3y.The University of Chicago for the U.S. i Atomic.-Energy Coamission/Energy Research and Develop- ,• ment-Ad_iaistratioal, 1974-77 Member, Committee for Radiation Studies, U.S. Public Health Service, 1951-55 Member, Committee on Cancer Diagnosis and Therapy, Panel on Chemotherapy, National Research Council, 1951-55 Member. Advisory Committee on Isotope Distribution, U.S. Atomic Energy Commission, 1952-56 United States Representative, First and Second Internatior.al Conferences on Peaceful Uses of Atomic Enerrv. Ccneva, 1955 and 1958 _ Boards and Committees (cont'd): Member, National Advisory B Medical Research Foundation - Menber of Advisory Cot:_itte II.S..Atomic Energy Commissi State, 1960 :'-.^ _' - Member, Expert Advisory Pan, rHealth Organization, Geneva Member,'Advisory Committee ~ Ceneral of the Army,'1961-7c Luember, Morison:Panal of thE Office of Science and Tachac of_ahe President',:~1963-65', -; Member, ;!edicil'ind Scientif Aill:Rogars Memotial Fund,_1 G :' 'Member;.-.EryCh=opoietin~Comni Znstitute~•:II:S:°;Public Haalt Member, Board of Scientific Cancer Institute, National I 1963-67 . Member,,=Spaee Biology Adviao Space Science and Applicatio .National Aeronautics and Spa 1968-70" Member, National Advisory Ca National Cancer Advisory Boa of Health,.1968-72 • Member,,Subcoamittee of the for Commissioner of Health, .Member, Medical Advisory Comi Commission of Cook County, 1: Member, Environmental Adviso: Edison.Company,.Chicago, 1971 Lfember,.International Board Medicc,.The Netherlands, 1971 Member, Editorial Board, Con2 McGrav-Hill, Inc. ;-~. - . .

509 Boards and Comnittees. (cont'd): Member, National Advisory Board of the Oklahoma Tledical Besearch Foundation,.1959-64 - Hember of Advisory CoL_ittee sent to Yugoslavia, II.S..itomic Energy Comnission and the Department of -'-State, 1960 :Membar; Expert Advisory Panel on Radiation, World rHealth Organization, Ceneva, 1960-65 -Henber;'Advisory Comnittee on Biophysics, Surgeon •General of the Arny, 1961-70 :Menber,- Horison Panel of the Wooldridge Commietee, --'Office-of Scieace-..and Tecbnology, Esecutive Office of.'the= Pre s idea t'; Henber, ;Sedical and Scientific Advisory.Board, i7ill..Hogars Menorial Fund,_1963-66 ,lfember;;7Erythropoietin Committee,'National'.Heart ,`.:Institutr;:II:S:=;Public Haalth Service, 1963-67 Hember, Board of Scientific Counselors, National Cancer Institute, National Institutes of Health. 1963-67 Hember,'=Spaee Biology Advisory Subcommittee,' Space Science and Applications Steering Comnittee, -National Aeronautics and Space Administration, 29fi8-70 Hember, National Advisory Cancer Council and National Cancer Advisory Board, National Institutes of Health,.1968-72 ` of the Hayor's Search Conmittee Member, Subcommittee for Commissioner of Health, Chicago, 1969 2Sember, 2iedical Advisory Committee, Civil Service Commission of Cook County, 1969 Member, Enviranmental Advisory Council, Commonvealth Edison.Company,.Chicago, 1970 Member,.International Board of Editors, Ercerpta Medi.ca;.The Netherlands, 1970-81 Member, 'Editorial Board, Contemporary Ftedicine and Surgery McGrav-Hill, Inc. • .,~.-

•Boards and Committees (cont'd): . '•Nember, President's Advisory Committee on the Puerto Rico Nuclear Center, University of.Puerto'Rico, San Juan,. 1970- Chairman, Committee on the Study of Postdoctoral •' Fellovship'and Trainaeship Programs in the Biomedical . Selencaa, Mational Academy or aClences-n-v.+.+ ;. Rasaarch Couacil, 1971- 72 : . Member,' Report Review Committee, National Academy 0 Sciences, 1971-72 C:K,C IYYi~bYiGiaKxllliClE1L'Si~d(ffHC~K616'('lfa<3~df K~K}l~i.'~lfid~T~'s'S~SI5Xi3CK~d0( . x13f iyu~BYMcX1YKw l4%tW0KJUS6 SXW . - . . . ~ Iastitute of Health and Public Health' oi er, IIli ~_l_ s a Iiamb ? R Advisery Committea 1969- ~ry - . . . ... . _ - . :•., Member, Board of Directors; member, Regional-Aavisory 7 State of Illiaois 14E~ dieal Deana f H o~n iL b ~ ~ i , a o er C °Hem . r~; K _=..-Me•mbar=,=•Dea4's-Advisory Committee for Education ia tha. Health.Flelds. State of Illinois armu.r,+'euolic.neaich Gdvisory Committee, State Illinois,.Board of Higher Education t e , m oa Tobacco and Health. Department of Health, Educatioa, .r:-; . . ,. •. •. -.!lambar; Advisory Committee on Personnel for Research, Americaa Cancer Society Member, Scientific Advisory Board, Institute for Advanced Learning in the Medical Sciences, City of Hope Medical Center, California,.1962- Mamber,-Board of Trustees, La Rabida Children's Hospita•1- and Research Center, Chicago, 1967- Director at Large, Board of Directors, Alpha Omega Alpha Honor Medical Society, 1967=11 Member, Committee on Honorary Memberships, Alpha - Omega Alpha Honor Mediqal Society, 1971- 72 ~c>ox~x~xn~c;~x~cxaxr~x ~xac~~ ~ ucxxa~zK~c Kxt~x~~xKx ~~c Tfid(~(Sr4tK4lKAdC$L~519XKS~i(.lEljiQU(7AU(YYrK . ber Liaison Subcommittee of the Joint Committee M and Welfare 511 ,.rds and Committees (cont'd); Member, Medical Advisory Board, L Foundation Member,-Scientific Advisory Commit Cancer Research, Philadelphia, 19: Hember,-Scientific Advisory Board, :obacco Research•- DSA, New York 1, Membei, Staeriag and Finance Commi Society ozvonatology, 1973 Member. Committee '. Professional : Institute of Medicine ec Chicago, : ,Hember,jEvaluatioa Committee, Na.r,_- pMedical Education;•:1966- Member Subcommittae on Henatopoiet '.System of,aha.Committee oa Ratia c g ;-=PhyaieaL Znpairmeat':=Aaeriea¢ Medic _:_Cbairaan;,:-Committee-oa Science Pol_' -'SeaIth; Tnatitute"of- Medicine, aati Sciencea;J972-73 u~~s.~ *he a__. Contemporary Medicine and Surgeryl5 Chairman;~Section.of Medical Scianc Acadeny.-of.>Sciences, 1974-;77 _-Hember, Committee on Federal Researrh on•Bic -" ',Etfects of Ionizing Radiation (FREIR). Natic tec;~•r: Medical Aspects of Atomic Warfare, : Commissioa Traiaing Program, Chicagc Fifth International Cancer Congress- International Congress of Radiology: Munich, 1959 International Society of Hematology, Cambridge, England, 1950; Munich, 19 American College of Physicians. Univ 1950 •. Symposium on Radiology, Cleveland, 1 Chicago Society of Internal Medicine Chicago Pathological Society, Chicag~ Northern Indiana Medical Society, Fo:

511 Boards and Committees (cont'd): . Member, Medical Advisory Board, Leukemia Research Foundation Member;_Scientific Advisory Committee, Institute for Cancer Research, Philadelphia, 1959- 72 -- :"Member,,-Scientific Advisory Board, The Council for , Tobacco .Research•- USA, New York 1954 - Chairman, 1981 - =; Membei, Stearing•and Financa Committee, American Society o2Vematology, 1973 - Member, Committee T•. Professional Education, Institute of Medicine ct r,btcago, 1967- The The mber,l.Evalnatioa:Committee, Na a onal Fund for ;Medical Education1966- ' Member,. Subcommittee on Bematopoietic and ~j-,,,phatic ',System_.of,ahe.Committee on Rating of Mental an~ ;=Phyaic a l_I ripairmeat;:`American. Medical Associatio..,' zq67 _'{ ` ~ -% -_,:ChairmanCommittee-on Science Policy Sor Medicine anc --'SeaIth; Tnstitute of Medicine, National Academy of • t'ontemporary 8iaicine ana a'tirgery 171W :' Chairman;f Saction.of Medical Sciences, Natioaal .'Academy>of_:Sciencea, 1974-•.77 . Member Committee oa Federal Research on Biological and Health ,Effects of Ionizing Radiation (FREIR), National Research Council, 1979 - 8 Lecturer: Medical Aspects of Atomic Aarfare, Atomic Energy Commission Training Progran, Chicago,.1950 Fifth•Irternational Cancer Congress, Paris, 1950 Internationil Congress of Radiology, London, 195,0; Munich, 1959 International Society of Hematology, University of Cambridge, England, 1950; Munich, 1959 American College of Physicians. University of Chicago, 1950 • • Symposium on Radiology, Cleveland, 1950 Chicago Society of Internal Medicine, Chicago, 1951 Chicago Pathological Society, Chicago, 1951 Northern Indiana Medical Societ;, Fort Wayne, 1951

512 Lecturer (cont'd): Utah Medical School, Salt Lake City, 1951 . Rheumatic Fevar Research Institute, Chicago, 1951 "&nov Your Chicago," course sponsored'.by University ' College, University of Chicago, at the Art Institute, Chicago, 1951 - Chicago. Cancer Research group, Billings Hospital, Chicago, 1951 - . . Hematotogy ctuo, Gnlcago, J.»i . . . • . .•y,~ Naval MediciL Raslasch Instituta, sponsorad by Amaricaax 1970 •' R. W. Stavart Memorial Leeture, PittRhurg1hAeaA..e n1 Medieine, 1952 Inatituta"of_Biological Sciences, Bethesda, 1951. :J ' NursingService Departnent, Chicago Chapter of Anerican 7451 . -. - -. :a...- .._ .. _ _ . - _ . - - . .. . . . r. 7~,ti -'Congressas-of_•the-International bociety or naeDacayvgy.~ ~ = =952;3 a=i 1954 Bt 1956; 1958; :Aasg_t:+,a..s,;oson, Rome,, Munich 1964 kh ; , oln, -:-Tokyo=;-7960; Maxteo-•City, 1902; Stoc CIBA Foundation,london: Conference on Experimental Leukaemias,.1953; Symposiun on Haemopoiasis, 1960 - . . .. . . . • •t: Janevay Lecture, Ameriean Radium Society, 1953 Symposium on Radiobiology,-Liege, 1954 . Burrell.0.._3alston_Lecture, University of Southarn' California, 1957 ' Alice Messinger Band Memorial Lecture in Hematology, University of Maryland, 1959 George llinot Memorial Lecture, American Medical Association, 1960 . Jacobaaus Memorial Lecture for-1962, Helsinki Malthe Foundation Lecture for 1962, Oslo Guest Lecturer, Argentine Cancer Society and Liga Argentina de Lucha contra el Cancer, Buenos Aires, 1963 Kennecott Lecture Series, University of Arizona, 1963 513 ccurer'(cont'd): Kretschmer Memorial Lecture, of Chicago-Chicago Society of Medical.Sciences/Syaposium, A' Hospital, Minneapolis,-1970 Synposiam Erythropoieticnm,[`Z' of the Faculty.of General Med: Prague, 1970 Symposium, eRadiobiology; Past Austin 2i. Brues,,Argonne Natic "11thi`Aanual Dvight.E:.Clark Lc lfed;eal-Sociaty', Oak-Ridge_Hat Conference-on Planning for Cat by-:Anericam-Cancer.;Society_an2 r.in~eoopera.tibn vith'Assoctdtic Coll'eges ~ Siashingtoa Special Session on the History Transplantation, Experinental Davia, Cwlifornix, .1971 . Scientific Session, The Instal Brenton•.Huggins as Chancellor Wol:ville, Nova Scotia, March, :-=s and Awards: Member, Alpha Omega Alpha Hono Member, Sigma Ei.'•t ~ Janeway Medal, Americaa Radium Robert Roesler de Villiers Ava 1956 I:alston Avard, University of S Borden Award for research in t Association of American Medica Elected Meaber, Academia Nacio Suenos Aires, 1963 l;oderr. bledi.cir.e Award for dist 1963 -

•(cont'd): Kretschner Memoria2 Lecture, Institute of lSedicine of Chicago-Cbicago Society of Internal Medicine, 1968 2tedica1 Sciences Symposium, Abbott-Northvestern }iospital, 'lianeapolis,'1970 Synposiun Erythropoieticum, bOth Scientific Conference of the Faculty of General Medicine, Charles University, Prague, 1970 . . -• •. , . ,, Synposiun, °Radiobiology, Past and Present," to honor Austin ti. Brues, Argonne National Laboratory,"1971 `llthi'Annual Dvight.E: Clark Lecture, 8oane Aaderson .Hedical-Society', Oak,Ridge National.Laboratory,.1971•:" : _ _. •' . - .. _. . .. .. - . ' Conferenceon Planning for Cancer Centers, sponsored by.Anerieaa:Cancer_Society;and 4iational Cancer.Institute'.. -an=cooperat3on vith'-Association of..Anezican'Medical.:.y 'ColTeges;: Siashington;:D.C.~,.':1971 :s - Special Session on the Eistory of Bone Marrov Transplantation, Experinental Sematology Society, Davis, Cxlifornia, 1971 ' - Scientifie Session, The Installation of Dr. Charles Brenton,8uggins as Chancellor of Acadia University, Liolfville, Nova Scotia, Harch, 1972 ~ ... .. .a. w .. .. .._~ fiono:s and Avards: k -- Member, Alpha Omega Alpha 8onor Medical Society Member, Sigma Xi Janeway Medal, American Radium Society, 1953* ' Robert Roesler de Villiers Award, Leukemia Society, 1956 Ralston Award, IIniversity of Southern California, 1957 . Borden Award for research in the medical sciences,' Association of American Medical Colleges, 1962• Elected Me=ber, Academia Nacional de Medicina de Buenos Aires, 1963 . lAoderr. Wedicine Award for distinguished achievement, 1963 .

514 t' d) E on ors and Awards ( . Hon ~ American Nuclear Society Award for distinguisSed service in th. advancement of nuclear sciences, 1963 Elected Member; National Academy of Sciences, 196S __ City of Hope National Medical Center Citation for disiin4uishedp leadership in medical education and researc!a, 1967 . ' . . , : . , ~y... : : . . .. . .. . - - - ' . -:'" Elected Fe11ow,.American Academy of Arts and Sornaes. 1967 Elected Master, American College of Physicians. 1968 ~;, The John Phillips Memorial Award, American College o: Physicians.' in recognition of distinguished achievement in 7a'.ersal Medicina. . . . . . . ._ .. ... :.. .. . . . . : ' -'-`.., L Theodore Roosevelt Rough Ri3ers Avard,.State of Hor'...a` Dakotji"~' Elected'a Lau:eate of the Lincoln Academy of Il:1~^;, and recipient of. Order of Lincoln in Medicine and Health. 1979,t~r.'? Societies. ~Y i ~ ~ 1 Y - Academia Nacional7de Medicina de _Suenoa Ai.-es•- Alp'na OmeqaAlpha Bonor Medical Society American Academy of Arts and Sciences ' American Association for Caneer Research . - American Association for the Advancement of Science American~College of-Physicians American MedicalAssociation'•' American NuclearSocietyAmerican Society for Clinical Investigation American Society for Experimental Pathology American Society of Hematology Association of Ame=ican Physicians Billings Medical Club Central Interurban Club 'Central Society for Clinical Research 515 BIBLIOGRAPHY Leon 0. Jacobson, M.D ~Sasserman, Jules H., and Jacobson, Leo: 'alcohol on the cerebral cortex and the cat. Arcnives of Neurology and Paychiatry, Jacobson, Leon Orris, and Dick, George bacterial flora of the nose. .;::crnaZ of the American Medical Associc 1941. Jacobson, Leon Orris, and Palmer, Walce differential diagnosis of duodenal ulce Medical Clinics of North America, 27: 1 Jacobson, Leon 0., and Palmer, Walter L anemia on gastric emptying. ;:stroenteroZogy, 1: 1133-1140, 1943. acobson, Leon 0.: The effect of estrog• ~:ood and bone marrow of mice. =ndocrinology, 34: 240-244, 1944. Jacobson, Leon 0.: Health hazards of atc :icc;o b.'edical Society Bulletin (daaksc Jacobson, Leon 0., Spurr, Charles L., Bc Scith, Taylor, Lushbaugh, Clarence, and itrogen mustard therapy. Studies on tF. 5is(8eta-chloroethyl)amine hydrochloride and allied disorders of the hemopoietic dournaZ of the American Medical Aasociac Jacobson, Leon 0., Marks, Edna R., and S effect of total body x-irradiation on a anemia. (Abstract) ?r?ceedings, Central Society for CZinica :54 6. .%;:,rnal of Laboratory and Clinical Medic Jacobson, Leon 0., Spurr, Charles L., Sm ~• F.: Radioactive phosphorus (P3t) and lustards) in the treatment of neoplastic of the hemopoietic system. ':edicaZ CZinics of florth Amertica, 31: 3-- Jacobson, Leon 0., and Marks, E. K.: The o! ionizing radiations in the tolerance :--io'cioZogy, 49: 286-298, 1947.

515 BIBLIOGRAPHY Leon 0. Jacobson, M.D. 1. Masserman, Jules H., and Jacobson, Leon 0.: Effects of ethyl . 'alcohol on the cerebral cortex and the hypothalamus of the cat. Archives of Neurology and Psychiatry, 43: 334-340, 1940. Jacobson, Leon Orris, and Dick, George F.: Normal and abnormal bacterial flora of the nose. Journal of the Amarican Medical Association, 217: 2222-2225, 1941. 3. Jacobson, Leon Orris, and Palmer, Walter Lincoln: The differential diagnosis of duodenal ulcer. Medical Clinics of North America, 27: 195-207, 1943. 4. Jacobson, Leon 0., and Palmer, Walter Lincoln: The effect of anemia on gastric emptying. Gastroenterology, 1: 1133-1140, 1943. Jacobson, Leon 0.: The effect of estrogens on the peripheral blood and bone marrov of mice. Endocrinolo5y, 34: 240-244, 1944. 6. Jacobson, Leon 0.: Health hazards of atomic energy. 7. Cnicago i•.'edical Society Bulletin (Jackson Park), 24: 5, 1946. Jacobson, Leon 0., Spurr, Charles L., Barron, E. S. Guzman, Smith, Taylor, Lushbaugh, Clarence, and Dick, George F.: Nitrogen mustard therapy. Studies on the efftct of methyl- bis(Beta-chloroethyl)amine hydrochloride on neoplastic diseases and allied disorders of the hemopoietic system. h Journal of the American Medical Association, 132: 263-271, 1946. 8. Jacobson, Leon 0., Harks, Edna K., and Simmons, Eric L.: The effect of total body x-irradiation on a pre-existing induced anemia. (Abstract) Proceedings, Central Society for Clinical Research, 19: 30, 11'46. Journal of LcSoratory and Clinical Idedicine, 32: 341, 1947. 9. Jacobson, Leon 0., Spurr, Charles L., Smith, T. R., and Dick, G. F.: Radioactive phosphorus (P32) and alkylamines (nitrogen mustards) in the treatment of neoplastic and allied diseases of the hemopoietic system. Medical Clinics of North America, 31: 3-18, 1947. 10. Jacobson, Leon 0., and Marks, E. K.: The hematological effects of ionizing radiations in the tolerance range. Radiociology, 49: 286-298, 1947.

11. Prosser, C. Ladd, Painter, E. E., Lisco, Hermann, Brues, Austin H., Jacobson, Leon 0., and Swift, H. N.: The clinical sequence of physiological effects of ionizing radiation in animals. Radiology, 49: 299-313, 1947. r 12. Spurr, Charles L., Jacobson, Leon 0., Smith, Taylor R., and Barron, E. S. Guzman: The clinical application of inethyl-bis (8-chloroethyl)amine hydrochloride to the treatment of lymphomas and allied dyscrasiss. In Approaches to Tumor Chenotaeraay (1st Ed.), Forest Ray Moulton (ed.), Lancaster Press Printing Co., Lancaster, Mass., Chap. V, pp. 306-318, 1947. 13. Spurr, C. L., Jacobson, Leon 0., Smith, I. R., and Barron, E. S. G.: The clinical application of a nitrogen mustard compound methyl-bis(Beca-chloroethyl)amine to the treatment of neoplastic disorders of the hemopoietic system. (Abstract) Cancer Research, 7: 51, 1947. 14. Brues, Austin M., and Jacobson, Leon 0.: Comparative therapeutic effects of radioactive and chemical agents in neoplastic diseases of the hemopoietic system. American Journal of Roent;enology and Radium TRerapy, 58: 774-782, 1947. 15. Jr.cobs Leon . 0.: The use of nic--e-_ m----=_ -= t.`.e -----=c_Z of neoplastic diseases. Cini.cago +£adiccl Society 3ullatin (8orth Shore), 3: 1947. 16. Stearner, S. P., Simmons, E. L., and Jacobson, Leon 0.: The effects of single dose total body x-irradiation on the peripheral blood of the rat. (Absttict) Anatomical Record, 99: 576, 1947. 17. Spurr, Charles L., Smith, Taylor R., and Jacobson, Leon 0.: Chemotherapy in human lymphomas, leukemias, and allied dis- orders of the hemopoietic system. Radiology, 50: 387-394, 1948. 18. Jacobson, L. 0., Marks, E. K., Gaston, E. 0., Simmons, E. L., and Block, H. H.: Studies on radiosensitivity of cells. Science, 107: 248-250, 1948. 19. 'Jacobson, Leon 0., and Simmons, Eric L.: The effect of splenectomy on radiostrontium toxicity. (Abstract) Anatomical Record, 100: 46, 1948. 20. Bloom, William, and Jacobson, Leon 0.: Some hematologic effects of irradiation. Blood, 3: 586-592, 1948. 517 -3- ._. Block, Matthew, Spurr, Charles L., Jacobs Smith, Taylor R.: Histopathologic effects mustard therapy upon normal and neoplasti tissues. American Journal of Clinical Pathology, I __. Jacobson, Leon 0., Marks, Edna K., and Ga Effect of BAL on cobalt-induced polycythe Proceedings of the Society for Experiment Medicine, 69: 84-86, 1948. , , 76 ^ _3. Block, :Satthev H., Jacobson, Leon O.,.Nea and Smith, Taylor R.: The use of radioars, treatment of leukemia and allied disorder= poietic tissues. (Abstract) - - JaurnaZ of Laboratory and Clinical Hedicir Allen, J. Garrott, Jacobson, Leon 0., and A study of the plasma defect in patients 'u cemporarily controlled by protamine sulfat (Abstract) dournal of Laborctory and CZiniccZ 16edicin Ducoff, Howard S., Neal, William B., Strau Jacobson, Leon 0., and Brues, Austin M.: 8 crith arsenic71 II. Excretion and tissue ed_aedicine,r69: 548-554, 1948. 31ock, Matthew, and Jacobson, Leon 0.:.The diagnosis of the osseous type of Gaucher's .:c:a 8aematoZcgica, 1: 165-177, 1948. Jacobson, Leon 0., and Smith, Taylor R.: T the present forms of treatment of polycyth =.-crican Practitioner, 3: 267-270, 1949. Jacobson, Leon 0., Stone, R. S., and Allen °hysicians~in an atomic war. Journal of the American 1ledic:2 Asaoeiatio) 1949. 5ogardus, George, Allen, J. Garrott, Jaeobe Spurr, Charles L.: Role of splenectomy in t purpura. ,froaives of Surgery, 56: 16-27, 1949. Jacobson, Leon 0., Marks, Edna K., and Lore hematological effects of ionizing radiatior. RadioZogy, 52: 371-395, 1949. "•arks, Edna K., Gaston, Evelyn 0., Jacobson 31ock, Matchev: The hematologic effects of .+merican Journal of ;:edieaZ Technology, IS:

21. 517 -3- Block, Matthew, Spurr, Charles L., Jacobson, Leon 0., and Smith, Taylor R.: Histopathologic effects of nitrogen mustard therapy upon normal and neoplascic hematopoietic tissues. Amertican Journal of ClinicaZ Pathotoay, 18: 671-689, 1948. 22. Jacobson, Leon 0., Marks, Edna K., and Gaston, Evelyn: Effect of BAL on cobalt-induced polycythemia in rats. Proceedings of tha Society for Es;erimentat Biology and Medicine, 69: 84-86, 1948. 23. Block, Matthew H., Jacobson, Leon 0., Neal, William B., and Smith, Taylor R.: The use of radioarsenic (As7i) in the treatment of leukemia and allied disorders of the hemato- poietic tissues. (Abstract) JournaZ of Laboratory and Clinical Medicine, 33: 1649, 1948. Allen, J. Garrott, Jacobson, Leon 0., and Grossman, Burton J.: A study of the plasma defect in patients whose bleeding is temporarily controlled by protamine sulfate or toluidine blue. (Abstract) JourncZ of Laboratory and Clinical lSedicine, 33: 1480, 1948. 25. Ducoff, Howard S., Neal, William B., Straube, Robert L., Jacobson, Leon 0., and Brues, Austin M.: Biological studies with arsenic7i II. Excretion and tissue localization. of :.a .ioc~rty ~~r ~:,u.virer.tuZ aio:oyy and t~!edicine,V69: 548-554, 1948. 26. Block, Matthew, and Jacobson, Leon 0.:. The histogenesis and diagnosis of the osseous type of Gaucher's disease. Acta flaematoZcgica, 1: 165-177, 1948. 27. Jacobson, Leon 0., and Smith, Taylor R.: The evaluation of the present forms of treatment of polycythemia rubra vera. Amcrican Practitioner, 3: 267-270, 1949. 28. Jacobson, Leon 0., Stone, R. S., and Allen, J. Garrott: Physicians in an atomic war. Journal of the American ifedi.caZ Association, 13.°: 138-140, 1949. 29. Bogardus, George, Allen, J. Carrott, Jacobson, Leon 0., and Spurr, Charles L.: Role of splenectomy in thrombopenic purpura. Arvitives of Surgery, 56: 16-27, 1949. 30. Jacobson, Leon 0., Marks, Edna K., and Lorenz, Egon: The hematological effects of ionizing radiations. AadioZogy, 52: 37L-395, 1949. 31. Marks, Edna K., Gaston, Evelyn 0., Jacobson, Leon 0., and Block, Matthew: The hematologic effects of nitrogen mustards. American Journal of 1•fedical Technology, 15: 1949.

518 -4- 519 -5- 32. Skirmont, Ellen, Marks, Edna K., and Jacobson, Leon 0.: A modified technique for• counting blood platelets. The American Journal of Medical TeehnoZogl, 15: 86-87, 1949 33. Jacobson, Leon 0., Marks, E. K., Gaston, E. 0., Robson, ;t., and Zirkle, R. E.: The role of the spleen in radiation injury. Proceedings of the Society for E:parimental Biology and Medicine, 70: 740-742, 1949. 34. Watson, Cecil James, Schwartz, Samuel, Schulze, William, Jacobson, Leon 0., and Zagaria, Ralph: Studies of coproporphyrin III. Idiopathic coproporphyrinuria; a hitherto unrecognized form characterized by lack of symptoms in spite of the excretion of large amounts of coproporphyrin. Journal of Clinical Investigation, 28: 465-468, 1949. 35. Jacobson, Leon 0., Marks, Edna K., Gaston, Evelyn, and Block, Matthew H.: The effects of nitrogen mustard on induced arythroblastic hyperplasia in rabbits. Journal of Laboratory and Clinical Medicine, 34: 902-924, 1949. 36. Block, Matthew, Jacobson, Leon 0., and Neal, William: Biologic studies with arsenic76. III. The effect of arsenic?6 upon the clinical course of patients with tumors of the hematopoietic tissues. JournaZ of Laboratory and Clinical Madicine, 34: 1366-1375, 1949 37. Jacobson, L. 0., Marks, E. K., Robson, M. J., Gaston, E., and Zirkle, R. E.: The effect of spleen protection on mortal'ty "following X-irradiation. Journal of Laboratory and Clinical Medicine, 34: 1538-1543, 1949. 38. Jacobson, Laon 0., Robson, :S. E., Marks, E. K., and Goldman, M. C.: The affect of X-irradiation on antibody formation. (Abstract) Journal of Laboratory and Clinical l4edicine, 34: 1612, 1949. Proceedings, Central Society for Clinical Research, 22: 40-41, 1949. 39. Jacobson, Leon 0., Simmons, Eric L., and Block, `tatthew &.: The effect of splenectomy on the toxicity of Sr" to the hematopoietic system of mice. Journal of Laboratory and Clinical Medicine, 34: 1640-1655, 1949. 40. Spuzr, Charles L., Smith, Taylor R., Block, Matthew, and Jacobson, Laon 0.: A clinical study of the use of nitrogen mustard therapy in polycythemia vera. Journal of Laboratory and ClinicaZ Mcdicine, 35: 252-264, 1950. Leon 0.: Splenic puncture. and Jacobson Matthew Blo k 41 , , , c . Journal of the American Medical Associatnon, 142: 641-647. 1950 42. Jacobson, L. 0., Simmons, E. L., Bethard, W. and Robson, H. J.: The influence of the splc recovery after irradiation injury. Proceedings of tha Society for Esperimental 73: 455-459, 1950. 43. Spurr, Charles L., Smith, Taylor R., Block, Jacobson, Leon 0.: The role of nitrogen mus: the treatment of lymphomas and leukemias. American Journal of Medicine, 8: 710-723, 1~ 44. Jacobson, L. 0., Simmons, E. L., Marks, E. : Bethard, W. F., and Gaston, E. 0.: The role radiation injury and recovery. Journal of Laboratory and Clinical Medicine, 4 5. Carpender, J. W. J., and Jacobson, Leon 0.: radioisotopes. In Therapeutic Radiology, U. V. Fortmann (e, 1950, pp. 697-709. 46. Huff, R. L., Bethard, W. F., Garcia, J. F., Jacobson, L. 0., and Lawrence, J. H.: Trace: studies in irradiated rats with lead-shield~ Journal of Laboratory and Clinical Medicine al. T?^^h. Leon 0.. Radiati^: i^,, ry .c. +9. 50. In A Testbook of Medicine (chap. "Diseases : Agents"), Russell L. Cecil••Loeh (ed.), W. B (8th °d.), pp. 524-529. (Also in 9th Ed., : 1959; and llth Ed., 1963.) . --_~ Jacobson, Leon 0., Robson, Melba J., and Ya effect of X radiation on antibody formation Proceedings of the Society for Ecperimental 75: 145-152, 1950. Jacobson, Leon 0., Simmons, Eric L., and Be Studies on hematopoietic recovery from radi (Abstract) - '- Journal of Clinical Investigation, 2:• 825, Bcthard, W. F., and Jacobson, L. 0.: Chemot and allied diseases. Southucstern Medicine, 31: 255-260, 1950. 51• Block, Matthew, and Jacobson, Leon 0.: Hyel ~'orrnaZ of the American Medical Association 1950. Jacobson, Leon 0.: Recovery from radiation Blood, 6: 769-770, 1951.

519 -5- ® 42. 43. 1 at f 04. 45. 9.~ ie„ he' 46. 194J] 417. 4E. Jacobson, L. 0 . , Simmons, E. L., Bethard, W. F., Marks, E. K., and Robson, M. J.: The influence of the spleen on hematopoietic recovery after irradiation injury. Proceedings of the Society for E:peri^+ental Biology and Medieir.e, 73: 455-459, 1950. Spurr, Charles L., Smith, Taylor R., Block, Matthew, and Jacobson, Leon 0.: The role of nitrogen mustard therapy in the treatment of lymphomas and leukemias. American Journal of Medicine, 8: 710-723, 1950. Jacobson, L. 0., Simmons, E. L., Marks, E. K., Robson, M. J., Bethard, W. F., and Gaston, E. 0.: The role of the spleen in radiation injury and recovery. Journal of Laboratory and Clinical Medicine, 35: 746-770, 1950. Carpender, J. W. J., and Jacobson. Leon 0.: Medical uses of radioisotopes. In TF.ercpeutic Radiology, U. V. Fortmana (ed.), Thomas Nelson, 1950, pp. 697-709. Huff, R. L., Bethard, W. F., Garcia, J. F., Roberts, B. Y., Jacobson, L. 0., and Lawrence, J. 8.: Tracer iron distribution studies in irradiated rats with lead-shielded spleens. Journal of Laboratory and CZinicaZ 1•ledicine, 30: 40-31, 1950. bs_ Leon 0.: Radiati^ i^j•ry Enr.Z Tentbook of Medicine (cha?.-"Diseases Due to Chemical Agents"), Russell L. Cecil••Loeb (ed.), 4. 8. Saunders, 1951 (8th *d.), pp. 524-529. (Also in 9th Ed., 1953; 10th Ed., 1959; and 11th Ed., 1963.) Jacobson, Leon 0., Robson, Melba J., and Yarks, Edna K.: The effect of X radiation on antibody formation. Proceedings of the Society for ErperimentaZ BtioZocd and d:edicine, 75: 145-152, 1950. 4 49. Jacobson, Leon 0., Simmons, Eric L., and Bethard, William F.: Studies on hematopoietic recovery from radiation injury. (Abstract) Journal of Clinical Investigation, 22: 825, 1950. S0. Bethard, S7. F., and Jacobson, L. 0.: Chemotherapy of neoplastic and allied diseases. Southwestern Medicine, 31: 255-260, 1950. S1. Block, Matthew, and Jacobson, Leon 0.: MyeLoid metaplasia. Journal of the American Medical Association, 143: 1390-1396, 950A 1950. 52. Jacobson, Leon 0.: Recovery from radiation injury. (Abstract) 195,. BZood, 6: 769-770, 1951.

520 -6- 53. Pearl, A., Bethard, W. F., and Jacobson, L. 0.: A Lucite syringe shield for protection against irradiation during intravenous administration of beta-emitting radioisotapes. Journal of Laboratory and Clinical Medicine, 36: 792-794, 1950. 54. Bethard, W. F., Skirmont, E., and Jacobson, Leon 0.: Effect of radiophosphorus on rats with cobalt-induced polycythamia. (Abstract) Journal of Laboratory and Clinical Medicine, 36: 800, 1950. Proeaedinga, Central Society for Clinical Reeearch, 23: 12, 1950. 55. Bethard, W. F., and Jacobson, L. 0.: Observations on survival of mice after exposure to lethal doses of X radiation. (Abstract) Journal of Clinical Investigation, 30: 629, 1951. 56. Block, Matthev, and Jacobson, Leon 0.: Management of the lymphomas Medical Clinics of North America, 35: 93-110, 1951. 57. Jacobson, L. 0., Simmons, E. L., Marks, E. K., Gaston, E. 0., Robson, M. J., and Eldredge, J. H.: Further studies on recovery from radiation injury. Journal of Laboratory and CZinicaZ Medicine, 37: 683-697, 1951. 58. Jacobson, Leon 0.: Further studies on factors influencing sA_ recovery from radiation inaury. (Abstract) Proceedinys of the Inatituta of Afedicine of CRicago, I8: 300-301, 1951. 59. Jacobson, L. 0., Simmons, E. L., Marks, E. K., and Eldredge, J. H.: Recovery from radiation injury. .eience, 713: 510-511, 1951. 60. Jacobson, Leon 0.: Studies on radiation injury. (Abstract) Proceedings of the Institute of h:..dicine of Chicago, 14: 326 1951. 61. Jacobson, Leon 0.: Medical and biologic aspects of radiation injury. In The Merck Report, 1951, pp• 27-32. (Also in 9th Ed., 1956; 10th Ed., 1960.) 62. Block, H.D., Jacobson, L. 0., and Neal, William: Biologic studies with arsenicIG. IV. The histopathologic effects of arsenic7s in patients with leukemia and related diseases. (Abstract) Journal of Laboratory and Clinical Ffedicir.e, 38: 792, 1951. : In Industrial ;4edicine on the PZutoniu:n et al 0 L ., . 63. Jacobson, . Project. R. H. Stone (ed.), National Nuclear Energy Series, ' 11 1952. Chap. 4, pp. New York Hill G 3 , rasr- vol. IV-20, Hc ,456 466•_ Chap. 5, pp. 140-196; Paper 5, pp. 425-455; Paper 6, pp. I 521 -7- 64. Jacobson, Leon 0.: Lymphosarcoma (in C of the Blood and Spleen"). In Current Therapy. Howard F. Conn (e, 1955, pp. 173-174. (Revised: 1955, pp pp. 201-202.) - 65. Jacobson, L. 0., and Robson, M. J.: Fac inhibition of antibody formation. - Journal of Laboratory and Clinical Medi 65. Jacobson, Leon 0.: Evidence for a humor concerned in recovery from radiation in Cancer Research, I2: 315-325, 1952. 57. Bethard, William F., and Jacobson, Leon application of radioactive isotopes. In The Treat,aent of Cancer and Allied D- Pack and Irving H. Ariel (eds.), Paul B. New York, 1952. (Revised, 1958.-) 03. Bethard, William F., and Jacobson, Leon polycythemia. In The Treatment of Cancer and AZliad Di Pack and Irving H. Ariel (eds.), Paul B. New York, 1952. (Revised, 1958.) Block, Matthew, Jacobson, Leon 0., and B 3one marrow in the diagnosis and treatme vera. (Abstract) ?roceedings of the Chicago PathoZogiccZ . 1952. ;D . Block, Matthew, and Jacobson, Leon 0.: D~ leukemia in human adults. (Abstract) Cancer Research, 22: 250, 1952. Block, Matthew, and Jacobson, Leon 0.: Th effects of ACTH or cortisone in patients (Abstract) . Car.cer Research, 12: 250, 1952. ' -- Block, >f. H., Bethard, W. F., and Jacobso hemachromatosis. (Abstract) - Journal of Laboratory and Clinical Medici Vissler, R. W., Robson, M. J., Fiteh, F., Jacobson, L. 0.: The effects of spleen sh: spleneetomy upon antibody formation in ra: body X-irradiation. - - .TournaZ of :mmunoZogy, 70: 379-365, 1953.

521 -7- 3 a ® 64. Jacobson, Leon 0.: Lymphosarcoma (in Chapter on "Diseases of the Blood and Spleen"). In Current Therapy. Hovard F. Conn (ed.), W. B. Saunders, 1955, pp. 173-174. (Revised: 1955, pp. 222-223; 1960, pp. 201-202.) 65. Jacobson, L. 0., and Robson, ri. J.: Factors effecting x-ray inhibition of antibody formation. Journal of Laboratory and Clinical Medicine,'39: 169-173, 1952. 66. Jacobson, Leon 0.: Evidence for a humoral factor (or factors) concerned in recovery from radiation injury: a review. Cancer Research, 12: 315-325, 1952. 67. Bethard, William F., and Jacobson, Leon 0.: The clinical application of radioactive isotopes. In The Treatment of Cancer and AZlied Diseases. George T. Pack and Irving M. Ariel (eds.), Paul B. Hoeber, Inc., New York, 1952. (Revised, 1958.) 69. Bethard, William F., and Jacobson, Leon 0.: The treatment of polycythemia. In T7.e Treatment of Cancer and AZZiad Diseases. George T. Pack and Irving M. Ariel (eds.), Paul B. Hoeber, Inc., New York, 1952. (Revised, 1958.) 69. Block, Matthew, Jacobson, Leon 0., ar.d Bethard, William: Bone marrow in the diagnosis and treatment of polycythemia Vera. (Abstract) Proceedings of the Chicago PathoZogical Sociaty, 19: 84-85, 1952. 70. Block, Matthev, and Jacobson, Leon 0.: Development of acute leukemia in human adults. (Abstract) Cancer Research, 12: 250, 1952. 71. Block, Matthew, and Jacobson, Leon 0.: The hiscopatholagic effects of ACTH or cortisone in patients with lymphomas. (Abstract) Cancer Research, 12: 250, 1952. " Block, :S. H., Bethard, W. F., and Jacobson, Leon 0.: Secondary hemachromatosis. (Abstract) Journal of Laboratory and Clinical Medicine, 40: 781, 1952. 73. Wissler, R. W., Robson, M. J., Fitch, F., Nelson, W.,.and Jacobson, L. 0.: The effects of spleen shielding and subsequent splenectomy upon antibody formation in rats receiving total- body X-irradiation. - Journal of ImmunoZogy, 70: 379-365, 1953. 72.

523 -9- 74. Block, Matthew, Jacobson, Leon 0., and Heal, William: ~ Biological studies with arsenic7s. IV. The histopathologic affect of arsenicrs upon the hematopoietic tissuus of patients with leukemia. JournaZ of Laboratory and CZinicaZ Medicine, 41: 499-515, 1953. 75. Block, Matthew, Jacobson, Leon 0., and Bcthard, William F.: Preleukemic acute buman leukemia. 'JournaZ of the American lfedicaZ Association, 152: 1018-1028, 1953. 76. Holleroft, Joanne, Lorenz, Egon, Congdon, Charles C., and . Jacobson, Leon 0.: Factors influencing the irradiation treatment of experimental lymphoid tumors. - Revista Mexicana de RadioZogia, 7: 115-124, 1953. 77. Bevtler, E., Robson, Melba J., and Jacobson, L. 0.: Prolong- ation of the lag phase of irradiated Escherichia coli. Proceedings of the Society for Esperimental dioloyj and 6;ediair.e, 85: 682-685, 1954. 78. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: Effets de la protection de la rate pendant 1'irradiation totale sur la formule sanguine du lapin. Revue d'=e.eatoZogie, 8: 515-532, 1953. 79. Jacobson, Leon 0.: The hematologic effects of ionizing radiation. In Radiation 3iobogy, vol. 1. Alexander Hollaender (ed. McGraw-Hill, New York, 1954, Chap. 16, pp. 1029-1090. 80. Jacobson, Leon 0., et al.: In Bio?:cical Effects ' External X and Gamma Radiation BioZecy. Raymond Zirkle (ed.), McGraw- Hill, 'lew York, 1954. Chap. 6, pp. 265-269; Chap. 10, pp. 317-329; Chap. 12, pp. 339-371; Chap. 21, pp. 473-516. 81. Jacobson, Leon 0.: Modification of radiation injury in experimental animals. Janeway Lecture, 1953. American Journal of P.oentgeno.Zooy and Radium Therapj,• 72: 543-555, 1954. 82. Jacobson, Leon 0., Marks, E. K., Gaston, E. 0., Simmons, E. L and Robson, H. J.: Modification of radiation injury. BuZletin of the ?Jeur York Academy of Medicine (second series 30: 675-692, 1954. ~ 83. Jacobson, Leon 0., Marks, Edna K., and Gaston, Evelyn'0: ~ Observations on the effect of spleen-shielding and the injectiop of cell suspensions on survival following irradiation. • ~~ , In Procc¢dings, Sth International Conoress of iicratoZoYy, Pcr:at ' 1954. Also in Proceedtinas, RadiobioZocy Syr.pesiam, Licye, _?4 1954. Z. M. Bacq and P. Alexander (eds.), 8utterwortha, LondoA~ pp. 122-133. Jacobson, Leon 0., Moore, Carl V., C (Yoderator, William Dameshek). IV. of a case presenting splenomegaly, p cellular marrow. 3:cad, 10: 753-763, 1955. Plzak, Louis F., Fried, Walter, Jacc ,illiam F.: Studies on Erythropoies: stinulation of erythropoiesis by plz FeSf. :ournaZ of Laboratory and CZinicaZ A Jacobson, Leon 0., at al.: Panel (Mc V. The use of cobalt and cobalt-irc therapy of anemia. Rlood, 10: 852-861, 1955. .:acobson, L. 0., Marks, E. K., and C of radiation injury in the rabbit. =rocecdinas of the Society for Espe: 91: 135-139, 1956. :acobson, L. 0., Marks, E. K., and C ..f rabbit liver cell suspensions on rabbits. (Abstract) >_c'.ation Researck, 5: 483, 1956. :acebson, Leon 0.: Hematopoietic res al P.eviev of Medicine, 7: 345-3` :acobson, Leon 0.: Modification of i rabbit. Presidential address, Chic:. ~c:obcr 10, 1955. (Abstract) ?rsceedinas of the Inatitute of Med: 7:-73, 1956. :acobson, Leon 0.: Hematologic recot =n rro_aress in RematoZogy. Grune ar _956. Fried, W., Plzak, L., Jacobson, I. C =r•+thropoiesis. II. Assay of eryth: :ats. rroceedings of the Society Expei ~..: 203-207, 1956. :acobson, 1. 0., Plzak, L., Fried, ti ':asna factor(s) influencing red ce: ::ure, 177: 1240, 1956. -.rcobson, Leon 0., et al.: (TID-522! ::._serr.aZ X and Gac-a Raiiation, I "d.), U.S. Atomic Energy Commissior :ervice Extension, 1956. Chapters = . • •r, O-i3Y--3q

523 -9- 84. Jacobson, Leon 0., Moore, Carl V., Crosby, William H.: Panel (Moderator, William Dameshek). IV. The therapeutic management of a case presenting splenomegaly, pancytopenia and a hypo- cellular marrow. Blood, 10: 753-763, 1955. 85. Plzak, Louis F., Fried, Walter, Jacobson, Leon 0., and Bethard, William F.: Studies on Erythropoiesis. 1. Demonstration of atimulation of erythropoiesis by plasma from anemic rats using Fes' . Journal of Laboratory and Clinical Medicine, 46: 671-678, 1955. 86. Jacobson, Leon 0., et al.: Panel (Moderator, William Dameshek). V. The uae of cobalt and cobalt-iron preparations in the therapy of anemia. Blood, 10: 852-861, 1955. 87. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: Modification of radiation injury in the rabbit. Procecdincs of the Seciet; for Esperimenta? 3ioZogy and Medicine, 91: 135-139, 1956. 88. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: The effect of rabbit liver cell suspensions on the survival of irradiated rabbits. (Abstract) Radiation Researci:, 5: 483, 1956. 89. Jacobson, Leon 0.: Hematopoietic responses to radiation injury. Annual Review of Medicine, 7: 345-352, 1956. 90. Jacobson, Leon 0.: Modification of radiation injury in the rabbit. Presidential address, Chicago Pathological Society, October 10, 1955. (Abst:sct) Proceedings of the Institute of Medicine of Chicago, 21: 72-73, 1956. 91. Jacobson, Leon 0.: Hematologic recovery from radiation injury. In Progress in Hematology. Grune and Stratton, pp. 311-317, 1956. 92. Fried, W., Plzak, L., Jacobson, L. 0., and Goldwasser, E.: Erythropoiesis. II. Assay of erythropoietin in hypophysactomized rats. Proceedings of the Society Experimental Biology and ,Nedic`.ne, 92: 203-207, 1956. 93. Jacobson, L. 0., Plzak, L., Fried, W., and Goldvasser, E.: Plasma factor(s) influencing red cell production. Nature, 177: 1240, 1956. 94. Jacobson, Leon 0., et al.: (TID-5220). In Biological Effects of External X and Ga.r..^:a Radiation, Part 2. Raymond Zirkle (ed.), U.S. Atomic Energy Commission Technical Information Service Extension, 1956. Chapters 4, 12, 13, 16, and 19. 95-077 0-82--34

523 -9- 74. Block, Matthew, Jacobson, Leon 0., and Neal, William: Biological studies with arsenic'76. IV. The histopathologic effect of arsenic7G upon the hematopoiecic tissues of patients with leukemia. Journal of Laboratory and Clinical Medicine, 42: 499-515, 1953. 75. Block, Matthew, Jacobson, Leon 0., and Bcthard, William F.: Preleukemic acute human leukemia. Journal of the American dledicaZ Association, 252: 1018-1028, 1953. 76. Hollcroft, Joanne, Lorenz, Egon, Congdon, Charles C., and Jacobson, Leon 0.: Factors influencing the irradiation treatment of experimental lymphoid tumors. Reviata Mexicana de RadioZogia, 7: 115-124, 1953. 77. Bevtler, E., Robson, Melba J., and Jacobson, L. 0.: Prolong- ' nia coZi. ation of the lag phase of irradiated Eseheric Proceedings of the Society for Esperi.r.enta2 3tialagy and 7:edicine, 85: 682-685, 1954. 78. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: Effets de la protection de la rate pendant 1'irradiation totale sur la formule sanguine du lapin. . Revue d'::e.^:atoZogie, 8: 515-532, 1953. 79. Jacobson, Leon 0.: The hematologic effects of ionizing radiation. - In Radiation Biology, vol. 1. Alexander Hollaender (ed.), McGraw-Hill, Few York, 1954, Chap. 16, pp. 1029-1090. 80. Jacobson, Leon 0., et al.: In Bio?:y^icaZ Effects of Erternai X and Gamma Radiation Biology. Raymond Zirkle (ed.), McGraw- Hill, New York, 1954. Chap. 8, pp. 265-289; Chap. 10, pp. 317-329; Chap. 12, pp. 339-371; Chap. 21, pp. 473-516. 81. Jacobson, Leon 0.: Modification of radiation injury in experimental animals. Janeway Lecture, 1953. American Journal of Roentgeno.Zogy and Radium Therapy, 72: 343-555, 1954. 82. Jacobson, Leon 0., Marks, E. K., Gaston, E. 0., Siamons, E. L. and Robson, ?l. J.: Modification of radiation injury. Bulletin of the tlew York Academy of Medictine (second series), 30: 675-692, 1954. and Gaston, Evelyn'0: Edna R. Marks Leon 0 b , , ., son, 83. Jaeo Observations on the effect of spleen-shielding and the injectioU -d ensions on survival following irradiation. , us ll E p ce s o In Prooeedings, 5th International Conarsss of iicnatoZoyV, Parit0 A c ge, ;, Radiooiology Symposiam, Li cs in Proceedin Al 1954 _ , so . 1954. 2. M. Bacq and P. Alexander (eds.), Bucterworths, London pp. 122-133. 84. Jacobson, Leon 0., Moore, Carl V., ( (Moderator, William Dameshek). IV. of a case presenting splenomegaly, p cellular marrow. Blood, 10: 753-763, 1955. 35. Plzak, Louis F., Fried, Walter, Jaco William F.: Studies on Erythropoiesi stimulation of erythropoiesis by pla Fessdournal of Laboratory and Clinical M. 86. Jacobson, Leon 0., et al.: Panel (Moc '_i. V. The use of cobalt and cobalt-iror therapy of anemia. Blood, 10: 852-861, 1955. Jacobson, L. 0., Harks, E. K., and Ga of radiation injury in the rabbit. ?roceedings of the Society for Esperi .!edicine, 91: 135-139, 1956. ' Jacobson, L. 0., Marks, E. K., and Ga of rabbit liver cell suspensions on t rabbits. (Abstract) Radiation Research, 5: 483, 1956. Jacobson, Leon 0.: Hematopoietic resp, .:nr.uaZ Review of Medieine, 7: 345-352 Jacobson, Leon 0.: Modification of rac rabbit. Presidential address, Chicagc October 10, 1955. (Abst:ect) ?roceedincs of the Institute of Medicd 72-73, 1956. Jacobson, Leon 0.: Hematologic recover In Progress in Hematology. Grune and 1956. ~., Fried, W., Plzak, L., Jacobson, L. 0., Erythropoiesis. II. Assay of erythrop rats. eroceedings of the Society Experim, 32: 203-207, 1956. Jacobson, L. 0., Plzak, L., Fried, W., ?lasma factor(s) influencing red cell ; 2ture, 177: 1240, 1956. .:acobson, Leon 0., et al.: (TID-5220). of Ea:ernaZ ;f and Ca.r,.-a Radiation, Part (ed.), U.S. Atomic Energy Commission Te Service Extension, 1956. Chapters 4, 1 `' Irl 0-82_34

-9- 84. Jacobson, Leon 0., Moore, Carl V., Crosby, William H.: Panel (Moderator, William Dameshek). IV. The therapeutic management of a case presenting splenomegaly, pancytopenia and a hypo- cellular marrow. BZood, 10: 753-763, 1955. 85. Plzak, Louis F., Fried, Walter, Jacobson, Leon 0., and Bethard, William F.: Studies on Erythropoiesis. I. Demonstration of stimulation of erythropoiesis by plasma from anemic rats using Fese Journal of Laboratory and CZinicaZ Medicine, 46: 671-678, 1955. 86. Jacobson, Leon 0., et al.: Panel (Moderator, William Dameshek). V. The use of cobalt and cobalt-iron preparations in the therapy of anemia. BZood, 10: 852-861, 1955. R-. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: Modification of radiation injury in the rabbit. Procecdinas of the Society for Esperi.r,enta? BioZogy and Medicine, 91: 135-139, 1956. - 88. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: The effect of rabbit liver cell suspensions on the survival of irradiated rabbits. (Abstract) Radiation Research, 5: 483, 1956. 89. Jacobson, Leon 0.: Hematopoietic responses to radiation in;ury. AnnuaZ P.eview of tifedieine, 7: 345-352, 1956. 90. Jacobson, Leon 0.: Modification of radiation injury in the rabbit. Presidential address, Chicago Pathological Society, October 10, 1955. (Abst:sct) Proceedings of the Inetitute of Medicine of Chicago, 22: 72-73, 1956. 91. Jacobson, Leon 0.: Hematologic recovery from radiation injury. In Progress in HematoZogy. Grune and Stratton, pp. 311-317, 1956. 92. Fried, W., Plzak, L., Jacobson, L. 0., and Goldvasser, E.: Erythropoiesis. II. Assay of erythropoietin in hypophysactomized rats. Proceedings of the Society EzperinentaZ BioZogy and Medicine, 92: 203-207, 1956. 93. Jacobson, L. 0., Plzak, L., Fried, W., and Goldwasser, E.: Plasma factor(s) influencing red cell production. ion Nature, 177: 1240, 1956. 94. Jacobson, Leon 0., et al.: (TID-5220). In BioZogticaZ Effects of EsternaZ X and Car.,.-a Ra:iation, Part 2. Raymond Zirkle (ed.), U.S. Atomic Energy Commission Technical Information Service Extension, 1956. Chapters 4, 12, 13, 16, and 19.

-10- 95. Simmons, Eric L., Jacobson, Leon 0., and Denko, Joanne: Studies on the mechanism of post-irradiation protection. In Advancez in Rad:obtioLoay. G. de Hevesy, A. Forasberg, and J. D. Abbatt (eds.), Oliver and Boyd Ltd., Edinburgh, pp. 214-219, 1956. 96.' Fried, W., Plzak, L. F., Jacobson, L. 0., and Goldwasser, E.: Studies on erythropoiesis. III. Factors controlling erythro- poietin production. Proceedings of the Society for E=perimentaL Biology and dadictine, 94: 237-241, 1957. . 97. Jacobson, L. 0., Goldwasser, E., Plzak, L. F., and Fried, W.: Studies on erythropoiesis. Part IV. Reticulocyte response . of hypophysectomized and polycythemic rodents to erythropoietin. Proceedir.gs of the Society for Esreri.^entaL Biology ar.d ?-:edic:r.e, 94: 243-249, 1957. 98. Jacobson, L. 0.: Added comment. In The Leuke^ias: Eticlogy, Pathoph.sio3ogy, and Treatment. John W. Rebuck, Frank H. Bethell, and Raymond %. Monto (eds,), Academic Press, Inc., 1957. (International Symposium, Henry Ford Hospital, Detroit) Pp. 183-184. 99. Jacobson, L. 0., Golduasser, E., Fried, W., and Pizak, L.: Role of the kidney in erythropoiesis. Rar._ , 179: 533-6'_'', '_•°5'. 100. Goldwasser, Eugene, Jacobson, Leon 0., Tried, Walter, and Plzak, Louis: Mechanism of the erythropoietic effect of cobalt. - Scicnce, 125: 1085-1086, 1957. 101. Nevell, Frank W., Beaman, Thomas C., Jacobson, Leon 0., :farks, Edna K., and Gaston, Evelyn: The effect of cell suspensions upon the development of cataracts in irradiated mice. AhA Archives of OphthaLmoZog,,, 57: 646-84d, Z957. 102. Jacobson, Leon 0.: Some aspects of the lymphoma problem. Journal of Cnronic Diseases, 6: 437-445, 1957. 103. Jacobson, Leon 0., Goldwasser, Eugene, Fried, Walter, and Plzak, Louis F.: Studies on erythropoiesis. VII. The role of the kidney in the production of erythropoietin. Transactions of the Association of Americar. ?hysticians, 7C: 305-317, 1957. 104. Jacobson, Leon 0., and Goldwasser, Eugene: The dynamic equilibrium of erythropoiesis. In Symposium on flomeostatic blacl:anisms. Brookhaven National Laboratory Symposia in Biology IC: 110-131, 1957. 105. Goldwasser, Eugene, Jacobson, Le 106. Plzak, Louis F.: Studies on eryt of cobalt on the production of e Blood, 13: 55-60, 1958. Goldwasser, Eugene, Fried, Walte Studies on erythropolesis. VIII on response to hypoxic anoxia . Journal of Laboratory and Clinic 107. Jacobson, L. 0„ Goldwasser, E., P 109. 110. lasma factors influencing eryth In Proceedinga of the Sixth Cong Society of Hematology, L956. Gr Pp• 777-782, 1958. Gurney, Clifford W., Jacobson, L_ugene: The physiologic and clin poietin. (Presented at the 39th American College of Physicians, April 30, 1958.) Anna:a of InternaL kedicine, 99: Jacobson, L. 0., Goldwasser, E., and Plzak, L.: Studies on erythr In Prceeedings of the Secor.d Int •H~ PP_cpryl +."cs ^;' At^.aic rr.sr Biochemistry and Physiology par , pp. 86-95. In Progress in j7uebear Energy Se. Sciences. Pergamon Press, 1959, Jacobs•n, Leon 0.: Hematological chapter on "Radiation Effects on In Radiation BioZogy and Cancer presented at the 12th Annual Sym- Research of the University of Te: and Tumor Institute. University 1958, Pp. 193-202. Simmons, Eric L., and Jacobson, ; radiation injury. - In Proceedings of the Sirth Inte. internattianaZ Society of Remato'l Stratton, New York, 1958, pp. 39 Jacobson, Leon 0., Goldvasser, E, Fried, Walter, and Plzak, Louis: The hormone regulating red cell . Annals of the New york Accdeny o. Jacobson, Leon 0., Goldvasser, E. of red cell formation. In Thc Kinetics of CeZZuZar Pro2: New York, 1959, pp. 344-356.

525 105. Goldwasser, Eugene, Jacobson, Leon 0., Fried, Walter, and Plzak, Louis F.: Studies on erythropoiesis. V. The effect of cobalt on the production of erythropoietin. 9Zood, 13: 55-60, 1958. 106. Goldwasser, Eugene, Fried, Walter, and Jacobson, Leon 0.: Studies on erythropoiesis. VIII. The effect of nephrectomy on response to hypoxic anoxia. Journal of Laboratory and Clinical Medicine, 52: 375-378, 1958. 107. Jacobson, L. 0., Goldwasser, E., Fried, W., and Plzak, L. F.: Plasma factors influencing erythropoiesis. In Proceedings of the Sirth Ccr.graaa of the International Society of Hematology, Z956. Grune and Stratton, New York, pp. 777-782, 1958. 108. Gurney, Clifford W., Jacobson, Leon 0., and Goldwasser, Eugene: The physiologic and clinical significance of erythro- poietin. (Presented at the 39th Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 30, 1958.) Ar.na:s of Internal kedicine, 49: 363-370, 1958. 109. Jacobson, L. 0., Goldwasser, E., Gurney, C. W., Fried, W., and Plzak, L.: Studies on erythropoiesis. In Prcceedings of the Second International Car.farer.ee on • !PC DP:_^r•;t nPet of Qtn,.i- t'r3roa • . Vol. 2h. Ise rCs in Biochemistry and Physiology, part 1, Sessioo D-13,1958, pp. 86-95. In Progress in 7ucZecr Er.ergy Series VI, Vcl. 2 - Biological Sciences. Pergamon Press, 1959, pp. 106-123. 110. Jacobs,n, Leon 0.: Hematological effects of irradiation (in chapter on "Radiation Effects on the Hematopoietic System"). In Radiation Biology and Cancer - Collection of papers presented at the 12th Annual Synposium on Fundamental Cancer Research of the University of Texas, K. D. Anderson Hospital and Tumor Institute. University of Texas Press, Austin, 1958, pp. 193-202. 111. Simmons, Eric L., and Jacobson, Leon 0.: Recovery from 112. radiation injury. In Proceedings of the Sisth International Congress of the International Society of flematoZogy, 1956. Grune and Stratton, New York, 1958, pp. 396-398. Jacobson, Leon 0., Goldwasser, Eugene, Gurney, Clifford W., Fried, Walter, and Plzak, Louis: Studies of erythropoietin: Thc hormone regulating red cell production. Annals of the New York Acc;:eny of Scienccs, 77: 551-573, 1959. Jacobson, Leon 0., Goldwasser, E., and Gurney, C. W.: Control of red cell formation. In The Kinetics of CeZZuZer Proliferation. Grune and Stratton, New York, 1959, pp. 344-356.

526 -12- 114. Jacobson, Leon 0., and Goldvasser, Eugene: Cite evidence for arythropoietia hormone role. Drnp Trade News, p. 4, March 23, 1959. 115. Siamons, Eric L., Jacobson, Leon 0., Harks, Edna K., and Gaston, Evelyn 0.: Long-term survival of irradiated mice treated with homologous tissue suspensions, lature, 183: 556, 1959. 116. Jacobson, Leon 0., Marks, Edna K., Gaston, Evelyn 0., and 4oldvasser, Eugene: Studies on erythropoiesis. %I. Reticulocyte response of transfusion-induced polycytbemic mice to anemie plasma from nephrectomized mice and to plasma from nephrectomized rats exposed to low oxygen. Blood, 24: 635-643, 1959. 117. Jacobson, Leon 0., Marks, Edna K., and Gaston, Evelyn 0.: Studies on erythropoiesis. XII. The effect of transfusion- induced polycythemia in the mother on the fetus. Blood, 14: 644-653, 1959. 118. Irantz, Sanford, Goldwasser, Eugene, and Jacobhon, feon 0.: o Studies on erythropoiesis. XIV. The relations ip hunoral stimulation to iron absorption. Blood, 14: 654-661, 1959. W. r,, C•«.^_ , C. W., aOldHa3S^_r, E,--d .Tar.ebsc^., L. 0.: Studies onerythropoietin. Recent Progress in Eormc*•e Research, 16: 219-262, 1960. 120. Jacobson, L. 0., Goldvasser, E., and Gurney, C. W.: Transfusion-induced polycythaemia as a model for studying factors influencing erythropoiesis. In Baamopoiesie: CaZZ Production and Its +legulatian. A CIBA Foundation Symposium, J. & A. Churchill, Ltd., London, 1960, pp. 423-445. - 121. Jacobson, Leon Orris, Goldvasser, Eugene, and Gurney, Clifford W.: Renal mechanisms and henatopoiesis. In dtioZogy of PyeZoneparitis. International Symposium sponsored by the Henry Ford Hospital, Detroit, Michigan Little, Brown 6 Co., Boston, 1960, pp. 569-579. 122. Jacobson, Leon 0., Gurney, Clifford t7., and Goldvasser, thropaiesis. r f l y e o Eugene: The contro In Advances in Internal i;edicir.e, Vol. Y. William Dock and I. Snapper (eds.), Year Book Publishers, Chicago, 1960, = pp. 297-327. 123. Jacobson, Leon: Lymphosarcoma: Method of Leon Jacobson, 2I.D. nders S B au . Iu Current Therapy. Howard F. Conn (ed.), W. Co., Philadelphia, 1960, pp. 201-202. :24. 125. 527 -13- Gurney, C. W., Jacobson, L. 0., and hormonal regulation of red cell proc In Clinical Endoorinodocu, Vol. I. Grune and Stratton, New York, 1960, Jacobson, Leon 0., and Simmons, Eric effects of isologous, homologous and tissues on post-irradiation survival Radiology, 75: 6-9, 1960. 126. Gurney, Clifford W., and Jacobson, L. erythropoietin. University of Michigan Medical BuZZe: --•• Jacobson, Leon 0., Marks, E. K., Gast -. L.: Some observations on the meche radiation injury. In ,Transacticns of the Ninth Internat Rcd'_oZogy, 1959, llunich. B. Rajewsky Verlag, Stuttgart, 1960, pp. 1073-107 -~• Jacobson, Leon 0.: The nature of radi In Ir,r.,unoh.ematoZo_oy and Ane.^ic. Proc S,vmposium on Hematology, 1960. ^c=a dae,-atoZogica Japonica, 23 (supp . ... Jacobson, i.enn f1., *tarye, Edna K., ai, Gaston, Evelyn 0.: Immune response in ?eyer's patch shielding. ?roceedings of the Society for Erperi;. 'ecicir•e, 108: 487-493, 1961. Gurney, C. W., Wackman, N., and Jacobs danage to the stem cell. In ?roceedir.as of the Conference on t% =n Ani.~naZ 3icZogy and the Medical Scie 1961, pp. 363-369. Jacobson, Leon 0.: The effect of trans :enatopoietic tissue on recovery from :n Proceedinas of tne VIIIth Internati ::a^ctoZoc:, 1950, Tokyo, Vol. 1. Pan ?P• 3-8. Jaeobson, L. 0., Simmons, E. L., Marks E. 0.: Recent atudies on recovery from transplantation of heterologous tissue Patch shielding in irradiated mice. =1 P^oceedings of the VIZIt$ Internatfc ematoZo_ay, 1900, Tokyo, Vol. 1. Pan F 7P• 8-9.

527 -13- 124. Gurney, C. W., Jacobson, L. 0., and Goldwasser, E.: The hormonal regulation of red cell production. In CZinicaZ Endocrinology, Vol. 1. Edwin B. Astwood (ed.), Grune and Stratton, New York, 1960, pp. 582-590. 125. Jacobson, Leon 0., and Simmons, Eric L. : Comparison of the effects of isologous, homologous and heterologous henatopoietic tissues on post-irradiation survival. RadioZogy, 75: 6-9, 1960. :26. Gurney, Clifford W., and Jacobson, Leon 0.: The kidney and erythropoietin. Ur.iversity of Michigan Medical BulZetin, 26: 271-277, 1960 1:7. Jacobson, Leon 0., Harks, E. F., Gaston, E. 0., and Simmons, E. L.: Some observations on the mechanism of recovery from radiation injury. - In Transacticns of the ainth International Congress of .4adiology, 1959, Munich. B. Rajewsky (ad.), George Thieme Verlag, Stuttgart, 1960, pp. 1073-1076. 126. Jacobson, Leon 0.: The nature of radiation anemia. In Inr.,unohe.~atoZoay and Ane.mia. Proceedings of the Kyoto Symposium on Hematology, 1960. Ac:c Rae-atoZocica .'aponiaa, 23 (suppl.), 1960, pp. 36-51. • 12'). Jacobson, t.enn !1. , urr!!•. Ed•_•z K, , Si==ons, -°ric L ,.nd Gaston, Evelyn 0.: Immune response in irradiated mice with Peyer's patch shielding. Proceedings of the Soeiety for Bsperimental Biolocy and h'edicir.e, 108: 487-493, 1961. 130. Gurney, C. W., Wackman, N., and Jacobson, L. 0.: Radiation damage to the stem cell. In Proceedings of the Conferer.ce on tne Use of Rcdioisotopes in Ar.imal BtioZogy and the Medical Sciences, Mexico City, 1961, pp. 363-369. 131. Jacobson, Leon 0.: The effect of transplantation of hematopoietic tissue on recovery from radiation injury. In Proceedir.gs of the VIIIth Internatior.al Conaress of Bem••atoloay, 2950, Tokyo, Vol. 1. Pan Pacific Press, 1962, pp. 3-8. 132. Jacobson, L. 0., Simmons, E. L., Marks, E. K., and Gaston, E. 0.: Recent studies on recovery from radiation injury after transplantation of heterologous tissue: Effect of Peyer's patch shielding in irradiated mice. In Proceedings of the VIIIth Interr.ationcl Cor.cress of Hematology, I9o0, Tokyo, Vol. 1. Pan Pacific Press, 1962, pp. 8-9.

529 -15- 133. Jacobson, L. 0., Haiks, E• &., Gaston, E. 0., and Simmons, E. L.: Some factors influencing the success of foreign hematopoletlc colonization o1S~utemie miceaaspdonortorn using transfusioa-induced p y Y recipients• In Proeeedings of the VIIIth IntarnationaZ Congreas o Bematology, 1960, Tokyo. 7o1. 1. Pan Pacific press, 1962, 116-120• pp. 134• Jacobson, L• 0.: Comments on the problem of the control of red cell formation• 1962, In Proceedings of thc VIIZ~o1 IIIarnPanoYacificgPress~t gematotogy, 1960, Tokyo, pp. 946-950. E., Gurney, C. W., Wackman, N., and Jacobson, 135. Filmanowicz, L. 0.: The response of the transfusion-induced polycythemic mouse to exogenous erythropoietin• In Proceedings of the Ylilth Intarnaptanopa~ificgPress~f1962, gematoLogy, 1960, Tokyo, Qol. II• pp. 950-956. thropoiet n. r f e y (eds.), 136. Jacobson, Leon 0.: Sites of formation o . Jacobson and *fargot Doyle In Erythropoieatia. Leon 0. 69-70. Grune and Stratcon, New Yok, 1962, pP• •137. Jaenbann, Lenn O., and Yaehnir., 9tat1^;: Their uses and abuses. ~'ide Abstraets of GeneraL !?ed=ctna, 6: 9-14, 1963. i/orLd- ~'i de138. Jacobson, Leon 0•t Radiation injury• 1g21- In Ta~tbook of ldedicine• Russell L•Chial 1and 963Ropprt r Loeb (eds.), W. B• Saunders, Yhiladei_p 1825. 139. Jacobson, Leon 0.: Erythropoietin and the regulation of the red blood cell formation. 6. 1963. Physiology for Physioians, 1: 1- 140• ~oc~heoadvances0in the medlcalnsciencesations and radioactivity act of Nuclear Energy on Society, Kennecott Lecture a Press, 1963, Im p f Arizon e ~ In Th Series, Number Eight, liniversicy o J pp. 21-34 • :EF-~y of 141. Bethard, W• P•, and Jacobson, L. 0.: The treatment polyeythemia• Chap• 12 in Treatrnent of Cancer and ALLied George T. Pack and Irving M. Vat. IX (Second Ed•)• Diseaces, Ariel (ads.), Paul B. Hoeber, Inc•, New Yozk, 1964, pp• 142. Jacobson, Leon 0.: Important unresolved prohlems of erythro- kinetics. Thaccher (ed.), Ross Laboratories, In AoLastie AnemzaReo=tGof the Forcy-eighch Ross Conference Columbus, 1966. ( P on Pediatric Research) 143. Jacobson, Leon 0.: Strides of the ps In Radiation Accidents and Emergenc: and Induatry. Lawrence H. Lanzl, Jc Rust (eds.), Charles C. Thomas, Spr2 144. Jacobson, Leon 0.: 80th birthday gre International Journal of Applied Rac 507-508, 1965 1:5. Jacobson, Leon 0.: Alf Sveo Alving. Traneacttio-ts of the Association of A 16. 1966. -46. Rowley, Janet D., Blaisdell, Richard Leon 0.: Chromosome studies in prele of Group C chromosomes in three pati BLood, 27: 782-799, 1966. Jacobson, Leon 0., and Krantz, Sanfo Conference on Erythropoietin. Annals of the Nerr York Academy of Sc 1968. Jacobson, Leon 0.: Toward a comprehe education. The Journal of t•ledicaZ Education, 43 Jacobson, Leon 0., and Landau, Richa in the education of inedicall students Chicago Clinics. Bu.Zetin af t)•.e Nerd York Academy of 44: 1401-1408, 1968. Krantz, Sanford B., and Jacobson, Le and the ReguLation of Erythropoiesis P:ess, Chicago, 1970. Jacobson, L. 0., Marks, E. R., and G of total-body X radiation on erythro rabbits. In The P.ecuLation of Erytnropoiesis Proceedings of the International Syn ?rague, 1970. Tomb§ TravniSek and J Universita Karlova, 1971. Jacobson, Leon 0.: Cancer centers an Cancer, 29: 835-839, 1972. 3ethard, liilliam F., and Jacobson, L classification of polycythemia. in ?cZycytheTia - Theory and Mana3a^ Charles C. Thomas, Springfield, 1973

529 -15- 143. Jacobson, Leon 0.: Strides of the past and present. In Radiction Accidents and Emergencies in Medicine, Research, and Industry. Lawrence H. Lanzl, John H. Pingel, and John H. Rust (eds.), Charles C. Thomas, Springfield, 1965. 144. Jacobson, Leon 0.: 80th birthday greetings to George Hevesy. Internationai Journal of AppZied Radiation and Isotopes, 26: 507-508, 1965 145. Jacobson, Leon 0.: Alf Sven Alving. TranFactiose of the Aasociation of American Physicians, 76: 16, 1966. 146. Rowley, Janet D., Blaisdell, Richard K., and Jacobson, Leon 0.: Chromosome studies in preleukemia. I. Aneuploidy of Group C chromosomes in three patients.. BZood, 27: 782-799, 1966. 147. Jacobson, Leon 0., and Krantz, Sanford B.: Summary of Conference on Erythropoietin. Annals of the New Yor.k Acade.ay of Sciences, 249: 578-583, 1968. 148. Jacobson, Leon 0.: Toward a comprehensive modern medical education. The Journal of wedicai Education, 43: 521-525, 1968. 1+9. Jacobson, Leon 0., and Landau, Richard L.: Group practice in the education of inedica7. students at the University of Chicago Clinics. Bulletin of the ?Jew York Academy of Kedicine (Second Series), 44: 1401-1408, 1968. 150. Krantz, Sanford B., and Jacobson, Leon 0. (eds.): Erjthrovciatirn and the P,ecu?ation of Erytnropoieaia. University of Chicago Press, Chicago. 1970. 151. Jacobson, L. 0., Marks, E. K., and Gaston, E. 0.: The effect of total-body X radiation on erythropoietin production in rabbits. In The ReauZation of Erytnropotiesia and Raemoa:ob:n Synt;Iesia, Proceedings of the International Symposiun Erythropoieticum, Prague, 1970. Tomat Travnitek and Jan Neuwirt (eds.), Universita Karlova, 1971. 152. Jacobson, Leon 0.: Cancer centers and research. Cancer, 29: 835-839, 1972. 153. Bethard, William F., and Jacobson, Leon 0.: Definition and classification of polycythemia. In PoZycythemia - Theory and ;.:ana3cnent. Herman Klein (ed.), Charles C. Thomas, Springfield, 1973. Chap. 2, pp. 18-24.

154. Klein, Herman, and Jacobson, Leon 0.: Management of the polycythemias. In Polycythemia - Theory and Management. Herman Klein (ed.), Charles C. Thomas, Springfield, 1973. Chap. 10, pp. 209-237. , .p 155. Jacobson, Leon 0., et al.: Postdoctoral Training in the Biomedical Sciences. An Evaluation of 11:CuS PostdoctoraZ Traineeship and FeZZouship Programs. Report of the Advisory Committee on the Study of NIGNS Postdoctoral Fellovships and Traineeships in the Biomedical Sciences, National Academy of Sciences-National Research Council, 1973. 156. Jacobson, L.O., Marks, E.K., and Gaston, E.O.: The Effect of total- _ body X radiation on erythropoietin production in rabbits. In The Regulation of Erythropoiesis and Haemoglobin Synthesis, Proceedings of the International Symposium Erythropoieticum, Prague, August 10 - 13, 1970. Tomas Travnicek and Jan Neuwirt (eds.), Universita Xarlova, 1971. 157. Jacobson. Leon 0.: Cancer centers and research. Cancer. 29: 835 - 839, 1972. 158. Bethard, William F., and Jacobson, Leon 0.: Definition and classification of polycythemia. Chap. 2 in Polycythemia - Theory and Management. Herman Klein (ed.), Chcarles C. Thomas, Springfield, Ill., 1973, pp. 1a-24. ' 159. Klein, Herman, and Jacobson, Leon 0.: Management of the polycythemias. Chap. 10 in Polyc/themias - Theory and eWnagement. Herman Klein (ed.), Charles C. Thomas, Springfield. Ill., 1973, pp. 209-237. 160. Jacobson, Leon 0.:' Progress in Internal Medicine: An Overviev. Comprehensive Therapy, 1: 49 - 51, 1975. 161. Jacobson, Leon 0.: From Atom to Eve. Perspectives in Biology and Medicine Richard L. Landau (Ed.), University of Chicago Press, Chicago, 11. (in press) 531 STATEMENT OF LAWRENCE I 1. Introductic I am Lawrence L. Kupper, ializing in epidemiology and :_rently Professor of Biostatis- ;:hlic Health, University of Nort have been a consultant to the L ;ency and a member of the Instru :m currently doing research und ..,~titute of Environmental Health Since 1967, I have been e _•?=earch with particular referenc °._olooical data on occupational b -lected member of the Regional Cc :-.erican Region of the Biometric :.'.:e American Statistical Associat ~?idemiologic Research. I have p :pproximately 100 scientific pape ;?card of the Journal of Chronic L vitae and list of publications ar