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487 8ioqraphical Sketch: Richard J. Nickey tUne: Richard James Nickcy tcae Address: 43 L. Clearfield Road, 8avertovn, Pa. 19083. losiness Address: Departnent of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pa. 19104. February 8, 1982 Birth Date: September 18, 1913. Birth Place: Rock Island, 111. Narital Status: llarried, four children. Tele one: Home: (215) SU-9-8356 Dusiness: (215) 243-6801 Naior Areas of Research Interest: -' 'Epidemioloqical relationships between environmental chemicals and other environmental variables and various life forms, particularly man; natural selection; ecological genetics; mutaqenasisr genetic polymorphismr human ecoloqy: ecological statistical analysist analysis of highly complex biolcgical systems, such as multi-reqional, multi-chemical .pidemiological systems that pertain to elucidation of etiologies of major human afflictions, such as cancer, cardiovascular diseases, and birth defects; environmental pollution and public healthr theoretical biologyt behavior genetics; ethology, the biology of behavior; the molecular biological basis of biological senescence and of the development of diseases of aging; scientific method- ology, valid and invalid; social consequences of abuse and misuse of stat- iatics and of science generally. Also hormesis. Lducation. College Level: Onivenitv of Illinois, Orbana, 1931-1935, B.S. in cheaistryt mathematics minor. University of Buffalo (N.Y.)(now S.II.N.Y.), graduate study in physical chemistry and cheriical physics. 1936-1936. 1 Iowa State IIniversity, Ames, 1936-1941, Ph.D., biophysical chemistry, minor in microbiology. Eonorary Societies: Sigma Xi, Pi Mu Epsilon, Phi Iambda Upsilon, Phi xapps Phi. Professional organizations: American Chemical Society; American Association for the Advancement of Science (AAAS Fellov)j New York Academy of Sciences; Enviraasmental Mutagen Society. T_.achinc Exeerience: Taught undergraduate chemistry at the University of Hnffalo and at Iova State University. j~ Professional Experience: t' September, 1975 to oresent: Department of Statistics, The Wharton School, Ohiversity of Pennsylvania, Philadelphia, Pa. Technical area as for August, 1973, to September,.1975.

488 2. Auvust 1973 to Septetrber 1975: Management and Behavioral Science Center, Wharton School, tlniversity of Pennsylvania, Philadelphia, Pennsylvania; relationships of environmental chemicals and other variables to chronic disease riska human ecology; population and molecular biology; theoreti- eal biology; biology of behavior; comple: biological systems analysis; sttltivariate analysis (applied); psychobiology and bioenerqetics. September 1967 to Auvust 1971: Snstitute of Environmental Studies, University of Pennsylvania; also associated with Fels Center of Covern- sent, Wharton School, University of Pennsylvania, and with the Reqioral Science Research Institute, Philadelpdtia, Pa.; environmental pollution and chronic disease relationshipsr human ecology; multivariate analysis; complex biological systems analysiss theoretical biology. 1963 to September 1967: University of PMttttsylvania. Institute for Co- operative Research, senior research investigator; mueh of these studies eoncezned national security and were classified. Studies included tech- nical evaluations and fusibility, and multivariate analysis of complex systems-eomputer oriented. Also worked on the air pollution-public health proqram as a complex systems analysis problem in human ecology with a preventive medicine orientation. 1958 to 1963: Research and Development Department, Covaereial Solvents Corporation, Terre Haute, Indiana. Planning and project analysis for Research and Development. Technical evaluations, feasibility studies, some market analysis and economic assessments. Work involved antibio- tics, vitami*.s and otSer ' t'_ sirial bie:hzc:c 'r . 1953 to 1958: University of Pennsylvania, Institute for Cooperative Research, senior research investigator. Work was somewhat similar to that of 1963-1967. Worked on computer-oriented predictive models of various sorts. Some work was published in scientific journals. 1941 to 1953: Similar to work of 1958-1%3, but more laboratory work. Was involved in research and development work for the first penicillin manufacturing plant ever built. Recent Abstracted Descriptions of Current Studies. " s Item $03: 'Eeoloqical Statistical, Etholoqical, and Other Biological Studies on Air Pollution, Smoking, and Other Environmental Variables and Their Rela- tion to Chronic Diseases in Plan,' pp. 326-327, in: 1976 Directory of On-6oinq Research in Ss.okinq and Health, U.S. Department of Health, Educa- tion and Welfare, PHS, Center for Disease Control, National Clearinghouse ` for Smoking and Health, Atlanta, Ga. Item 834/12.76: •Ecoloqical Statistical, Etholoqical, and Related Biological Studies on Air Pollution, Smoking, and Other Environmental Variables and Their Relation to Chronic Diseases in t4an,• pp. 384-385, in: Directory of On-Coinq Research in Cancer Epide+oioloov, 1977; International Agency for Research on Cancer (IARC), Lyon, France; Deutsches.Rrebsforschungzentrum (DKFZ), Heidelberg, West Germany. (IARC Scientific Publ. No. 17). 489 List of Fublica Ir_'userial Nicrobioloev and Hioehemistr~ Shriner. R. L.. and Hickey, R.J.. Urethans as lo aminopropylcarbamates,1 Am. Chem. So Chem. Soc. 63. 3549 (1941). .. Fulmer, E. I.. Hickey, R. J.. and Underkofler. L dation with ceric sulfate in fermenution m. Anal. Ed. 12, 729-30 (1940). 3. Hici:ey, R. J., Sterility test for penicillin employir 232-4 (1945). . 4. H1c):ey, R. J., In vitro evidence of regeneration of Science. 101, 462-3 (1945). _ H,ckey, R. J.. The inactivation of iron by 2, 2'-bip; syntttesis by Clostridium acetoburylicum, : 5. Fulmer. E. I., Underkofler, L. A. and Hiekey, R Patent 2, 388, 840 (1945). Oi:bert. W. J., and Hickey, R. J.. Production of c cillium notatum, L Bact. 51, 731-3 (1946). B. H:ckey, R. J., Preeipitation of riboflavin from aqu duction, Arch. Biochem. 11. 259-67 (1946; 3. H;ckey, R. J., Production of riboflavin by buryl alc Patent 2,425.280 (1947). 1J. F.+:mer.- E. I., Underkofler, L. A., and Hickey, ; taaon process, U. S. Patent 2, 416,745 (19 :1. ;:ckey• R. J., A note on detergent interference in using Bacillus subtilis. j. 8act. S, 43-4 ( .-. Nickey, R. J., and Hidy, P. H., Crystalline fradic :~. Y.idy, P. H., and Hickey, R. J., Z1te isolation of c Arch. Biochem. Biophys. 34, . 67-71 (1951) 14. linderkofler. L. A., Fulmer, 1. i., Hickey, R. J by fermentation. 1. Fermentation of dezt: (1951). Hickey, R. J., Oral therapeutic tablets (Penicillin;

a- 489 ;. • List of Publications Industaal Mic-ttioloov and 3ioc5ea+iscrv 1. Shriner. R. L.. and Hickey. R. J.. Urethans as local anesthetics (V), alkyl cJ-diethyl- aminopropylcarbamates,1 Am. Chem. Soc. 61, 888-9 (1939); correction, 1 Am. C>em. Soc. 63. 3549 (1941). 2. Fulmer. E. 1.. Hickey. R. J.. and Underkofler, L. A., Determination of glycerol by ozi- dation with ceric sulfate in fermentation media containing deztrose, Ind. Er.s;. C`em., Anal. Ed. 12. 729-30 (1940). 3. Hickey, R. J., Sterility test for penicillin employing cysteine for inactivation, Science. 101. 232-4 (1945). 4. Hickey, R. J.. In vttro evidence of regeneration of active penicillin :rom penicillin esters, Science, 101. 462-3 (1945). . 5. Hicitey, R. J.. The inactivation of iron by 2, 2'-bipyridine and tu effect on riboflavin synLhesis by Clostrtdium acetoburylicum. Arch. Biochem. 8, 439-47 (1945). 6. Fulmer, E. I., Underkofler, L. A. and Hickey, R. J.. Glycerol production, U. S. Patent 2,388.840 (1945). 7. Gilbert. W. J., and Hickey, R. J.. Production of conidla in submerged cultures of ?enl- cillium noutum. L Bact. 51, 731-3 (1946). >Q 8. Hickey, R. J., Precipitation of riboflavin from aqueous solution by bacteriological re- duction, Arch. Biochem. 11, 259-67 (1946). 9. Hickey, R. J., Productlon of riboflavin by buryl alcohol-producing bacteria, U. S. Patent 2,425, 280 {1947). 10. Fulmer,- E. I., Underkofler, L. A., and Hickey, R. J., Glycerol production by fermen- tation procesa, U. S. Patent 2,416,745 (1947). 11. Hickey. R. J.. A note on detergent interference in the serial dilution assay of penicillin using Bacillus subcilis. j.. Bact. 55. 43-4 (1948). 12. Hickey, R. J., and Hidy, P. H., Crystalline fradicin, Science 113, 361-2 (1951). 13. Hidy, P. H., and Hickey, R. J., The Isolation of cystalllne fradicin from fermentation media. Arch. ch. Blochem. Blophys. 34, 67-71 (1951). Underkofler, L. A., Fulmer, $. I., Hickey. R. J., and Lees, T. M., Prodbction of glycerol by fermentation. 1. Fermentation of dextrose, Iowa State Cll. 1. Sci. 26. 111 33 14. Hickey. R. J., Oral therapeutic tablets (Penicillin), U'.S. Patent 2,566,200 (1951).

490 16. Hfckey, R. J., Production of ribo0avtn, U.S. Patent 2.605,210 (1952). 17. Hickey, R. J., Corum, C. J., Htdy, P. H., Cohen, I. R., Nager. U.P.B., and Kropp, E.. Ascosin, an antifungal antibiotic produced by a sffeptomycete, Antibiotics and Chemot.lerapy 2, 472-83 (1952). 18. Hickey, R.J., and Tresner. H. D., A cobalt-containing medium for sporulatioa of Streotomyces species. i Bact. 64, 841-2 (1952). 19. Hickey, R. J., Production of penicillin, U.S. Patent 2,615,830 (1952). 20. Hiekey. R. J., Some autrttional requirements for biosynthesis of riboflavin by Eremo- theciurtt ash.byii. L Eact., 66, 27-33 (1953). 21. Hickey, A. J., I?se antagonisrn between the antifungal anribiotic, ascoatn, and some Ioog- ehaln, unsaturated fatty aclds. Arch. Blochem. Biophye. 46, 331-6 (1953). 22. Underkofler. L. A., and Hickey, R. J. (editors), '7adustrial Fermentationa', Vol. I, (bock), Chemical Publishing Co., New York. 1954. Includes a chapter by W.N. Mc`lstcban and R. J. 8ickey on'"fhe butanol-acetone fenentation.• 23. UnderkoIIer, L. A., and Hickey, R. J. (editors), "Iaduetrial Fermentations", Vol. II(book), Chemical Publishing Co., New York, 1954. Ineludes a chapter by R. J. 6ickey - an "Production of riboflavin by feraentation," and a chapter by R.J. Rickey and A. R. Stanley on "Miscellaneous fermentations." 24. HIckey, R. J., and Phillips. W. F., Separatyon.of Aureomyc:n from Terramycia by counter- current distributtoa and by paper chromatwgraphy. Anal. Cbem. 26, 1640-2 (1954). 25. 26. 27. 491 Nu.:an Eoidemioloav: yulti-Reeional Relationc.`.ins of Er Chezuals and other Enviranncn:ol Var:abics ta Human r yarlate Statistics: Y'nu1at]on Bialoav: ta:,olooyr Mut3 :.q:nv: Scientafie Metnodoloav: Hehavioral Ph•:sioloav; 29. Woodbury, M.A., Clcllond, R.C., and Hickey, R.J. Analytic Modelin the Prediction oi Biological Dato, o 347-354 (1963). 30. Hickey, R.J., Scboff, E.P., and C(elland, P..C., Rel Pollution and Certain Chronic Disease Deoth Rates, Ar 728-733 (1967). 31. Hickey, R.J., Boyce, D.E., Homer, E.B., and Clell 32. Stotistical Studies.:oncaming Environmental Pollution IEEE Trans. Geoscience Electronics G"c_8, 1E6-202 (1 was puoiisnea in IEu Sccana Inrernasionat Geoscience Digest of rapers, pp. i3-i, 13-2, Aorii 14-17, 17r., Hickey, R.J., Boyce, D.E., Homer, E.B., and Clell: Statistical Studies on Environmental Pollution and Cire Areas or tna uni:ca S:c^s, "viscu.-sion i•cner Series Nc Researcir insritute, Fniiaceiphia, Pennsylvania, Cctob 33. Hickey, R.J., Air Pelluticn, Chapter 9, in Murdoch, Rcsources, Pollution cnd Soci ety, Sinauer Associates, pp. 1a9-212. Hickey, R. J., Soluble ascostn composition and method for preparing same, U.S. Patent 34. Rickey, R.J., Harner, E.B., cnd Clelland, R.C., Sr. 2,748,053 (1956). , Health, Lancat ii, 1362-3 (1972). Hickey. R. J.. Production of riboflavin by Ashbva gossyptl with cobalt as additive, U.S. 35. -Hickey, R.J., CIelland, R.C., and Harner, E.B., Sr Patent 2,667,445 (1954). Develcpment, and PollWion, Lcncet i, 270 (1973). a Hickey. R. J., Survey of fermentations. This was a paper presented at a symposium on 36. Hickey, P..J., Hamar. E.B., Clelland, R.C., and Be Non-food Uses of Carbohydrates at the American Chemical Society cor:vestlon, Atlantic City, September, 1959. 28. 1liakey, R. J., •8aeitraein, Its Manufacture and qses,• a ohapter, pp. 94-150, in - Vbl. V of the isook series, Procress in Industrial Microbioloav, D.J.D. Rockenhull, Rli:oi, Heyvood and Co., Ltd,, London, 1964. .. Regulation of Physiological Homeosta;is: Smoking, Po; Naturvrissenschorten 60, 206-7 (1973). 37. Hickey, R.J., Harner, E.B., 'Ethological and Biouse and Their Relotionships to Smakir.g", Chapter 19, in D Smoking Bcnaviar: Motives cnd Incentives, V.H. Wir iresnint" g.^ •o., i , yp. 267-282. 3s. Hickcy, R.J., Clcllond, R.C., Harner, E.B., and Bc Smoking, Pollution, and Cdrdiovoscular Disease; A P: lancet i, IC03 (1973). a - 39. Hickey, R.J., Homer, E.B., Clelland, R.C., and Bc Hazords to the Fetus, Brit. Med. J. 3, 501 (1973); c

. 491 Huvn Eeide.r.ioloav: !7ult?-RCeional Relations`.ios of Enviror., ental Fbllutanc C'nesicals ar•d othcr Envireancn:nl var:aDics to Auaan Morta_.c•: FateS; Xu1t:- variate Stat:stics: Population Bioloav; Etholoarv_Muraaer.esa; 3tcloe•, of TginS: Scientific Mcar.odoloav; behavioral Ph•:siolcqv; Feyenociolocv• 29. 30. 31. 32. Woodbury, M.A., Clclland, R.C., and Hickey, R.J., Aopfications of a Foctor- Anaiytic llodel in the Prediction of Biological Data, Bei:evioral Science 3, 347-354 (1963). . ~ Hickey, R.J., Sc/+off, E.P., and Cfelland, R.C., Relationship between Air Pollution and Certain Chrenic Disease Death Rates, Arch. Erviron. Health 15 728-723 (1967). Hickey', R.J., Boyce, O.E., Hcmer, E.B., ond Clelland, R.C., Ecalogiczl Stotistical Studies._onceming Environmental Pollution cnd Chronic Disecse, IEEE Trans. Geoscience Elec'ronics G-c`SJ 136-202 (1970). (Cctober). (Summary wns nuollsneo in IEcc Sec_na Inremationat Geoscience ElcctrcniaSymposium, Digest of P=ers, pp. i3-l, 13-2, April 14-17, 197u, Washirsytcu, D.C.) Hickey, R.J., Boyce, D.E., Homer, E.B., and Clellend, R.C., Ecolocical Statistical S'udies on Environmental Pollution and Chronic i)7se1e in N,errcooiitcn Areas or sna unlrcn Disa•usion i•cper Series No. 55, ~egionai Science Research Insritute, Pnitoceiphia, Pennsylvania, October, 1970. S. 33. Hickey, R.J., Air Peilution, Cha;::er 9, in i:iurdoch, Ed., Ewiren-~rr'r; Rcsourcas, Pollution cnd Society, Sincuer Associates, Inc., Stamford, Cor•n., 1971, pp. 89-212. ~ . . 34. Flickey, R.J., Hamcr, E.B„ end Clelland, R.C., Smoking, Pollution, and Health, Lancat ii, 1362v" (1972). 35. -Hickey, R.J., Clelland, R.C., end Harner, E.B., Smoking,. Birth-Weight, Development, and Pollttion, Lcncet i, 270 (1973). n 36. Hickey, P..J., Hamxr. E.B., Clelland, R.C., and Boyce, D.E•, Behaviorel Regulation of Physialogieal Homeostazis : Smoking, Pollution and Health, Naturnissenscnorten 60, 206-7 (1973). 37. 3s. Hickey, R.J., Harner, E.B., "Ethological end Biocisemicol Interactions ond Their Relationships to Smokir.g°, Chapter 19, in Dunn, W.L., Jr., Ed., Smoking Sehavior; Motives and Incentives, V. H. Winston 3 Sars, Inc., osn;ngton, D. . , / , yp. 767-262. , Hickey, R.J., Clelland, R.C., Harner, E.B., and Boyce, D.E., Coffee Drinking, Smoking, Pollution, and Cardiovascular Disease: A Prob!em of Self-Selection, Lancet i, 1003 (1973). 39. Hickey, R.J., Homer, E.B., Clelland, R.C., and Boyce, D.E., Smoking Hazards to the Fetus, Brit. Med. J. 3, 501 (1973); correction, ibid., p. 552. 95-077 0-82-32

492 6. 40. Hickey, R.J., Qucstions end comments in: L.M. LeCcm, J. Neymon, and E.L. Scott, Editors, Proceedines eF The Sixth cerkeley Symcesium and 7/,ethe.^..e- tical Stctistics and Prcoczi I,y; Vo(. VI, tt:cc:s ci Poi u icn on necan t:, University or cliiornia ?ress, ~erKetey, 1972. 41. Hickey, R.J., Clelland, R.C., and Boyce, D.E., Carbon Monoxide: Smoking, Air Pollution, Cardiovascular Disease, and Physiological Hpmeostasis, Lancet ii, 571-2 (1973). 42. < Hickey, R.J., Clcllcnd, R.C., and 3oyce, D. E., Coffee and MyocardialIr.- farction, New Engl. J. Med. 289, 978-9 (1973). 43. Hickey, R.J., Boyce, D.E., Clellond, R.C., end Harner, E.B., Smoking and 44. Pregnancy, Nature 245, 177-8 (1973). Hickey, R.J., Clelland, R.C., Boyce, D.E., and Homer, E.B., Air Pollution, Smoking and Chronic Disease: Influence of Constitutional Factors, J. Occuo. Med. 16, 4-5 (1974). 45. Hickey, R.J., Clelland, R,C., and Boyce, D.E., Aryl Hydrocarbons, Smoking 46. 47. 48. and Lung Cancer, New Engl. J. Med. 290, 576-7 (1974) Hickey, R.J., Clellcnd, •e•.C. 9oyce, D.E., er.d H^.rner, E.B., Carbon Mono- xide and smokirgi Lancet 1, 409-10 (1974). Hickey, R.J., Clelland, R.C., Boyce, D.E., end Bowers, E.J., Coffee, Tobacco, and Cardiovascular Disease: The Se i-Selection Problem, J. Amer. Med. Asse-. 228, 160 (1974). aa Hickey, R.J., Clelland, R.C., Boyce, D.E., cnd Bowers, E.J., Atmospheric sulfur dioxide, nitrogen dioxide and lead as mutegenic hazards to human health, Mutation Res. 26, 445-6 (1974). (abstract). 49. Hickey, R.J., Boyce, D.E., Harner, E.B „ and Clellond, R.C., reproduction of IEEE Trnns. Geosci. Electronics paper (item 3, this list), with minor editing, in apter nvironmenta o lution and Human Health", Berry, B.J.L., and Horton, F.E., Editors,,Urban Environmental Management: Planning for Pollution Co~ntrol, Prentise }(o , Inc., tng ewood if s, N. .r , pp. 317- .iqV. _ F So. Hickey, R.J., Clelland, R.C., Boyce, D.E., and Bowers, E.J., Carbon monoxide, smoking, and conetitution, Lancet ii, 786-7 (1974). 51. Hickey, R.J., Clelland, R.C., Boyce, D.E., and Bowcrs, E.J., Smoking, health, and confusion, J. Amer. Med. Assoc. 230, 209-10 (1974). ,:_ . . 493 52. Hickey, R.J., Cleilo'r+d, R.C., Boyce, D.E., & o carcinegen? Amer. Rev. Reso. Dis. III, 105-t $3. Hickey, R.J., Clellond, R.C., Boyce, D.E., & Environmentol & constitutional factors. Lancet 54. Hickey, R.J., Clelland, R.C., Boyce, D.E., a hemoglobin levels. J. Amer. Med. As__oa. 232 55. Hickey, R.J., Clelland, R.C., 8oyee, D.E., a Cigarette smoke as a carcinogen? Amer. Rev. (1975). 56. tiickey, R.J., Clelland, R.C., 8oyce, D.E., a gen oxides, tobacco smoke, and chronic disea Health 30, 423-424 (1975). Reply: Freeman, 57. Hickey, R.J., Clelland, R.C., Hoa+ers, E.J., effects of atmospheric sulfur dioxide and di fallacy of typology. Arch. Environ. Health Rebuttal: Alarie, Y., ibid., 110-112. 58. Hickey, R.J., Clelland, R.C., 8overs. E.J., oxidase deficiency. Arch. Environ. Health ? a reply to a preceding discussion Sy Orev, R Rajagopalan, X.V., ibid. p. 141. 59. Hickey, R.J., and Clelland, R.C., Causes of and associated atherosclerotic disease: Envi tutional factors. In: Nicotine and Carbon t' Proceedines. Lexington, Xentucky, Universi and Health Research Institute, pp. 162-172, 60. Hickey, R.J., Boyce, D.E., Rarner, E$., and ato ~rv Studies o` Variables Related to Chroni Rates. Ptsiladelphia, University of Yennsylv (N:ZS No. pB-246,383, U.S. Department of CoR 1975). R(ckey, R.J., Eoyce, D.E., Clelland, R.C.,° Slater, P.B., Demograohic and Chemical Varia Disease Mortality in Man. Technical Report the Department of Statistics, The Wharton Sc Pennsylvania, Ahiladelphia, pa., 19174, June 61. 62. xickey, R.J.: 'Relationship betveen air pol Section 111, pp 89-122, ih: Governmental Or Air Resource Manaqement and Control S••stem i. Government Studies Center, Fels Insitute of . University of Pa., Philadelphia, A., Nov., : 63. Hickey, R.J.: Environmental Pollution and C for Environmentsl Studies, and Fels InstitutGovernment, University of Pa.t and Regional Philadelphia, P.., October, 1969, 50 pp. prelie.inary report to sponsors.)

493 <se .PL i .It .Lt 52. Hickey, R.J., Clcllaisd, R.C., Boyce, D.E., & 8owers, E.J., Cigarette smoke cs o corcincgen? Amer. Rev. Rcso. Dis. I11, IC5-6 (1975) 53. Hickey, R.J., Clelland, R.C., Boyce, D.E., & 9awers, E.J., Carboxyncemoglobin; Environmentol & constitutional foctors. lancet i, 40-41 (1975). 54. Hickey, R.J., Clelland, R.C., 9oyce. D.E., and Bovers,E.J., Carboxy- hemoglobin levels. J. Amer. Med. Assoc. 232, 486 (1975). 55. Hickey, A.J., Clelland, R.C., Boyce. D.E., and Bowers, E.J., Cigarette smoke as a carcinogen? Amer. Rev. Rso. Dis. 112, 149 (1975). ~ 56. Hickey, R.J., Clelland, R.C., Boyce, D.E., and Bowers, E.J., Nitro- gen oxides, tobacco smoke, and chronic disease. Arch. Environ. Health 30, 423-424 (1975). Reply: Freeman, G., ibid., 424. 57. Rickey, R.J., Clelland, R.C., Bowers. E.J., and Boyce, D.E., Health effects of atmospheric sulfur dioxide and dietary sulfitas. The fallacy of typology. Arch. Environ. Healtl 31, 108-110 (1976). . Rebuttale Alarie, Y., ibid., 110-112. - 58. Hickey, R.J., Clelland, R.C., Bowers, E.J., and Boyce, D.E., Sulfite oxidase deficiency. Arc!s. :nviron. Health 3j: 141-142 (1977). This is a reply to a preceding discussion by Drev, R.T., Johnson, J.Z., and Rajagopa/an. X.V., ibid. p. 141. 59. Hickey, R.J., and Clelland, R.C., Causes of carboxyhemoglobinemia and associated atherosclerotic disease: Environmental and Consti- tutional £actors. In: Nicotine and Carbon Monoxide - A Svmoosium: Proceedinas. Lexington, Kentucky, University of Kentucky Tobacco and Health Research Institute, pp. 162-172, June, 1977. 60. Hickey, A.J., Boyce, D.E., Rarner, EJ3., and Clelland, R.C., Exolor- ato ~rv Studies of Variables Related to Chronic Disease Mortali:v Rates. Philadelphia, University of Pennsylvania, 1971, 185 pp. (NTIS No. PB-246,383, U.S. Department of Commerce, Springfield, Va., 61. 1975). Rickey, R.J., Boyce, D.E., Clelland, R.C.,Bovers, E.J., and Slater, P.H., Demograohic and Chemical Variables Related to Chronic Disease Mortality in Man. Technical Report No. 15, issued from the Department of Stat:stics, The Wharton School, University of Pennsylvania, Philadelphia, Pa., 19174, June 30, 1976, 51 pages. 62. Hickey, R.J.: 'Relationahi2 between air pollution and health', Section III, pp 89-122, ih: Gover+mental Oraanization for an •• Air Resource Manaaement and Control S••stem in the Penjerdel Region. Government Studies Center, Fels Insitute of Local and State Government, University of Pa., Philadelphia, Pa., Nov., 1968. 63. Hickey, R.J.: Environmental Pollution and Chronic Disease. Institute for Environmental Studies, and Fels Institute of Local and State Government, University of Pa.J and Regional Science Research Institute, Philadelphia, Pa., October, 1969, 50 pp. (This was a limited distribution preliainary report to sponsors.) . •

494 e. 64. Rickey, R.J., and Clelland, R.C., Hazardous food additives: -Nitzite and saliva? New Enql. J. Ned. 292, 1036-1037 (1978). 65. Hickey, R.J., Clelland, R.C., and Bowers, E.J., Naternal smoking, birth weight, infant death, and the self-selection problem. Amer. J. Obstet. GVnecol. L3.1, 805-811 (1976). 66. Rickey, R.J.. Cancer etiology. Ch_ . II:v. News L7(1): 37 (1979) Iletter). 67. Rickey, R.J., Clelland, R.C., and Bowers, E.J.: Essential hormones as carcinogenic hazards. J. Octup..Med. _21: 265-268 (1979). 68. Rickey, R.J., and Bowers, E.J.: Smoking in pregnancy. Collected Letters Int. Correso. Soc. Obstet. necol. 20(11): 64-65.(1979). (Invited paper). 69. Rickey, R.J., Clelland, R.C., and C1e11and, A.3.r Epideniological studies of chronic disease: Naladjustment of observed mortality rates. Amer. J. Public Health 70: 142-150 (1980). 70. Rickey, R.J., Clelland, R.C., and Clelland, A.B.: (c alcohol intake and CHD. Am. J. Public Realth 70- 746-747 (1980). Reply to E. 7ano et al., ibid, p. 746. 71. Hickey, R.J., Bowers, E.J., Spence, D.E., Zemel, B.S., Clelland, A.B., and Clelland, R.C.: Low-level ionizing radiation and human mortality: Hulti- regional epidesiological studies. A preliminary report. Health Physics 40: 625-641 (1981). 72. Rickey, R.J., Hormesis. Nuclear News, November, 1981, p. 18. (letter). 73. Rickey, R.J., Hozmesis. Nuclear News, December, 1981, pp. 52,54,55. (letter). 74. Rickey, R.J., Bowers, E.J., Zemel, B.S., Clelland, A.a., and Clelland, R.C., Low-level ioniring radiation and human nortality. Healt3 Physics, 1982 (in press). 75. Rickey, R.J., and Bowers, E.J., Roraesis and Physiological Homeostasis. In: Encyelonaedia of Physics in Medicine and 9ioiovv__ (Edited by T.P. Mc4:zsh). Pesgamon Press, Ltd., Oxford, 1982 (in press). 76. Rickey, R.J., Clelland, R.C., and Clelland, a.B., B'-ostatistics. :n: Encyelo- paedia of Physics in Medicine and Biology (Edited by T.P. riUinsh). ?ergacon Press, Ltd., Cz:ord, 1982 (;.n press). 77. Hickey, R.J., Clelland, R.C., Bowers, E.J., and Clelland, a.9., Chemicals and cancer. Cyem. tTq. News 19(25): 4(1981)(June 22).(letter). 78. Rickey, R.J., Cancer and cos'sensus. Chem. J+q. !iews L9(37): 65,75 (1981). (Septeober 14)(letter). 79. Hickey, R.J., Bowers, E.J., and Clelland, R.C., Radiation homesis, public haalth, and public policy. A co®antary. Health 4hysics, 1982 (in press). 80. Hickey. R.J., Clelland, A.B., Clelland, R.C., Zemel, B.S., and Bowers. E.J., Ionizing radiation and human mortality: Multivariate analysis of 0.5. state data. Am. J. Physical Anthropology Se4(2): 233 (1981). (abstract). 81. Rickey, R.J., Clelland, R.C., Bowers, E.J., and Clelland, A.B., Associations involving environmental lead. Am. J. Cbstet. Gynecol. 140: 481 (1981). (correspondence). 495 . COLLEGE OF MEDICINE AND C NEWJERSEY MED 100 Berjen Newark,Ner Jer Statemen". of Duncan Hutcheon, M.r Departmeats of Pharlnacolc March 12, 19 7Aa C.Ye10 at M.qtlaa a O.MIqr ef t/e. )ewP Y. Nd asyar