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Present Appointment: Medical Education: Prizes: Other Degrees and Diplomas• Senior Lecturer in Child Health and Honorary Consultant Paediatrician. St Georqe's Hospital Medical School, Cranmer Terrace, London,. SW17 lat and 2nd M.H., Tinqs CoIleqe. London University. M.H., B.S. (1966), St Georqe's Hospital, Londoa Uri•rersity. Brackenbury Prize in Medicine, St Georqe'a Hospital Medical School, 1965. MRCP (London) 1968. M D (London) 1973. Thesis title: 'Malnutrition and Body Temoerature in Jamaican Habies".. FRCP (London) 1980. Previous Aooointments: 1966-67 - House Physician to Medical Unit, St George's _ Hospital, London, SW1 - Senior House Officer to Neurological Unit, Atkinson Morley's Hospital, London, SW20 1967-68 - House Surgeon to Mr Riddell, St George's Hospital London, SW17 1969 - House Physician to Prof. Hywaters, Hammersmith Hospital and Royal Postgraduate Medical School. 1969-72 - Scientific Officer, Medical Research Council, Tropical Metabolism Research Unit, University of the West Indies, Jamaica. 1972-73 - Member of Scientific Staff, Division of Human Physioloqy, National Institute for Medical - Research, Hamostead. 1973-74 - Paediatric Registrar, St Mary's Hospital. London, W2. 1974-76 - Senior Registrar in Paediatrics. St Mary's Hospital, London, W2. 2 34€ Scientific Societies: Member of Nutritior Physiolog Neonatal British F European Other Scientific Activities: Paediatri Member of European low birth-weiqht in Society of Paediatr

I 345 © Scientific Societies: Member of Nutrition Society Physiological Society Neonatal Society British Paediatric Association European. Society of Paediatric Gastroenterology a- Nutrition Paediatric Research Society. Other Scientific Member of European Advisory Co®ittee on feeding of Activities: low birth-weight infants, organised by the European Society of Paediatric Castroenterology and Nutrition. t. Is 3 f

346 3 Invited contributions at scientific meetinqs: S_ V Internatianal Pediatric Conaress, Buenos Aires, 1974. Co-ordinator of Colloqutum on Protein~alorie Malnutrition, and urvited speaker. 8th International Svmposium on Paediatric Work Physioloqy,_Bisham Abbey, 1976. Invited speaker. Nationa' Conference on Development and Handicap. Nnttingham Dniversity, 1977. .Iavited speaker. Conference on Neonatal Medicine, Institute of Obstetrics, Queen Charlotte's Hospital, 1979. Invited speaker. A~sl Colleqe of Physicians Paediatric Conference, 1979 "Nutrition in Paediarrics". Invited speaker. Nutritlon Society Symoosium on Nutrition in the Mother and Child, Royal Society of Medicine, 1979. Invited speaker. Conference on the Biology of Development, Hopital Necker, Paris, 1980. Iavited speaker. _ 8yI International Pediatric Concress, Barcelona, 1980. Contributor to Symposium on Neonatal Nutrition Annual Conference of Royal College of Radiologists, London, 1980. Invited speaker. 4 347 Paners presented at Scientific Meetings "Influence of Malnutrition on centrai body 16th Scientific Meeting of the Standing Adv Research in the British Caribbean, Barbados "Defective thermoregulation in malnourished 17th Scientific Meeting of the Standing Adv Research in the British Caribbean, Nassau. "Specific dynamic action in malnutrition".- 1st international Symposi= on Energy Balanc "The metabolic rate of malnourished chi]dr.er Physiological Society Meeting, Medical Resee "zvaluation of a method for measuring urine °ox, James & Thornton, 1973. Physiological `sedical School, London. i. 'Resting metabolic rate in malnourished chil total body potassium". Brooke, 1974. Collc XIV International Pediatric Congress, Buenos "High calorie feeding in protein-calorie sal :7heeler, 1974. Colloquium on protein-calori Pediatric Congress, Buenos Aires. "Ethnic differences in neonatal anthropometr- vecnatal Society Meeting, Nottingham Univers. 9. 'High energy feeding in low birt's-wei,rht infz Neonatal Society Meeting, St Thomas' Hospita_ 1."'hermorequlation in Malnourished Children". th International Symposium of Paediatric Wor -•• 'Influence of acidosis on energy absorption i 48th Annual Meeting of British Paediatric Ass =3- '"he role of the neonatal paediatrician in pr 3rooke, 1977. National Conference on Develop. Jniversity. :3. "POstprandial energy expenditure in small-for Alvear & Brooke, 1977. European Society for 1 and Nutrition, Dtrecht Meeting. 5"SPecific Dynamic Action in infants of low bi ?hysioloqical Society Meeting, St George's Bos •O- "POstprandial metabolism in low-birth-weight - 43 t` Annual Meeting of British Paediatric A_ssc '+utrition and Metabolism). "High energy feeding in immature infants" . E Z-nd European Nutrition Conference, Munich. '°ner;y cost of growth, in healthy iamtatLZe ir. "curopean Society for Paediatric Gastroenterolc O W ~ _QY ~ ~ 7 0-82-23 ~ ~ ~,-_u

0 347 4 papers presented at Scientific Meetings 1. "Znfluence of Malnutrition on central body temperature". Brooke, 1971. 16th Scientific Meetinq of the Standing Advisory Co®ittee for Medical Research in the British Caribbean, Barbados. 2. "Defective thermoregulation in malnourished Jamaican babies". Brooke, 1972. 17th Scientific Meeting of the Standing Advisory Committee for Medical Research in the British Caribbean, Nassau. 3. "Specific dynamic action in malnutrition".. Ashworth, Brooke & Waterlow, 1972. 1st International Symposium on Energy Balance in Man, Paris. 4. "The metabolic rate of malnourished chi]dren". Brooke & Cocks, 1973.' Physiological Society Meeting, Medical Research Council_ Mill Hill, London. 5. "Evaluation of a method for measuring isine temperature". Brooke, Collins, Fox, James & Thornton, 1973. Physiological Society Meeting, Royal Postgraduate Medical School, London. 6. "Resting metabolic rate in malnourished children and its relationship with total body potassium". Brooke, 1974. Colloquium on protein-calorie malnutritic SV International Pediatric Congress, Buenos Aires. 7. "High calorie feeding in protein-calorie malnutrition". Ashworth, Brooke & Wheeler, 1974. Colloquium on protein-calorie malnutrition, 7¢v International Pediatric Congress, Buenos Aires. 8. "Ethnic differences in neonatal anthropometric measurements". Brooke, 1975. Neonatal Society Meeting, Nottingham University. 9. "High energy feeding in low birt's-waight infants". Brooke, 1975. Neonatal Society Meeting, St Thomas' Hospital, London. 10. "High energy feeding in immature infants" . Brooke'& Alvear, 1976. 2nd European Nutrition Conference, Munich. 11."Thermoregulation in Malnourished ChiIdren". Brooke, 1976. Hth International Symposium of Paediatric Work Physiology, Bisham Abbey,Eagland. 12. "Influence of acidosis on energy absorption in immature infants". Brooke,1977. 48th Annual Meeting of British Paediatric Association, York. (plenary session). 13. "The role of the neonatal paediatrician in preventing visual handicap". Brooke, 1977. National Conference on Development and Handicap, Nottingham University. 14. "Postprandial energy expenditure in small-for-dates and immature infants". Alvear & Brooke, 1977. European Society for Paediatric Gastroenterology and Nutrition, Dtrecht Meeting. 15. "Specific Dynamic Action in infants of low birth-weight". Alvear & Bxooke, 197' Physiological Society Meeting, St George's Hospital, London. 16. "Postprandial metabolism in low-birth-weight infants". Brooke, 1978. 49th Annual Meeting of British Paediatric Asscciation, York. (section on Nutrition and metabolism). 17 "Energy cost of growth, in healthy immatvze infants". 9rooke & Alvear, 1978. European Society _`or Paediatric Gastroenterology and :7utrition, Paris Meeting. 95-077 0-82--23

6 19. "Stools in infancy: frequency. weight,. watar a energy content".. a Brooks, 1978. Paediatric Research Society !leetinq. Plymouth. 20. "Circadian rhythms of inelatonin and cyclic-AMP in neonat.s". Lvans, Carter, Brooks a Smith, 1978. Paediatric Research Society Meetinq, Plymouth. 21. "Lffects of supplementary vitamin D during pregnancy and Asian woman and their infants". Brooks, Eoae, Brovn._ Carter, Naxwell.a Robinson, 1979. 50th Annual Meeting of British Paediatric Association, York (plenary session). 22 "Lnerqy balance in infancy". Brooke,. 1979. Coaference on Neonatal Medicine. Itutitute of Obstetrica, Queen Charlotte's Hospital,. London. 23. "Laerqy metabolism in the neonate and malnourished thild'. Brooke, 1979. Royal College of Physicians Annual Pasdiatric Conference, Royal College of Physicians, London. 25. "Intestinal bypass in the rat: a model for 1Cwashiorkor?". Maxwell, McGowan a Brooke, 1979. international Conference on Infant Feedinq and Diarrhoeal Disease, Kuala Lumpur. 26. "Lysoryme, IqA and carbonic anhydrase levels in the milk of mothers of praterm and fullterm infants". Brooke, Carter, West & Wood, 1980. Neonatal Society Meetinq, Institute of Child Health, London. 27. "Chanqes in human fetal minaral metrbolism associ.ated with maternal vitamia D ~~ supplementation". Brooks, Brown & Cleeve, 1980. Biochemical Society Meeting, Surrey Dniversity. 28. "Energy balance in low birth-weight infants". Brooke, 1980.. Conferenee an ~ Biology of Development. Hopital Necker, Paris. 29. 'NeonataS reapiratory distress'. Brooke, 1980. Annual meeting of Royal College of Radiologists, London. 30. •Protaia concentrations in milk fr- mothers of preterm and term iafants". Br'ooker Carter, Hibbsrdr Wood & BrowII,(1980). Biochemical Society Meeting, St Georqe's Hospital, London. 'riqinal Seientific Publications Mechanism of action of /$-adrenerqic receptor b: ailson, Brooke, Lloyd and Robinson (1969). Brit.Me< .. Effect of erqotamine and erqometrine on forearm Brooke and Robinson (1970). Srit.Msd.J. J 139. 7. Iron absorption and pyresia. . aaresford, Neale and Brooke (1971). Lancet 1 , 568. 4. The influence of malnutrition on the post-prand Y otient. Brooke and Ashworth, (1972). Brit.J.Nutr. 27, 407. Influence of salnutrition on the body tamperatu zooke (1972). Brit.Ned.J. 1, 331. i. Eypothermia in malnourished Jamaican children. zrcoke (1972). Arch.Dis.Childh. 47, 525. Thermorequlatory instability in kernicterus. Brooke (1972). W.Ind.Med.J. 21, 253. 8. A simple metabOlism chamber allowing accurate c va;.er loss in large babies. Brooke (1972). ii.Iad.Med.J. 21, 202. 3, Specific dynamic action ia malnutrition. asnworth, Brooke and Waterlow (1972). Proceedings cz energy balance in men (ad. Apfelbaum and Miller 10. Fasting hypoqlycaamia due to increased glucose nlqh insulin. . . . ssrr, Brooke and Robinson (1972). Ped.Res. Gj_399 -1- The metabolic rate of malnourished children. srooks and Cocks (1973). J.Physiol. (Lond.) 231, -~. Evaluation of a method for measuring urine tes Brooke, Collins, Fox, James and Thomiton (1973). .7. Response of malnourished babies to cold. arooke• Barris and Salvosa (1973). J.Physiol. (Lc ~+• =".~ermal insulation in malnourished Jamaiean be Brooke and riarch (1973). Arch.Dis.childh. 48, 90] =S• Response of malnourished babies to heat. RrOcke and Salvosa (1974). Arch.Dis.Childh. 49, : The importance of routine urine cultis:es'in m, Brooke and Kerr (1974). J.1Yop.Pediat. 19, 348. -'• Resting metabolic rate in malrtourished babies Brooke and Cocks (1974). Acta.Paed.Scand. 63, 81 •a- Serum and Liver txiqlycerides in malnourished *_ores, Seakins and Brooke (1974). Am.J.Clin-:7utr =3- Measurements of deep body temperature from tk "Ox. arooke,COllins, Bailey and Healey (1975). .

349 0 Original Scientific Publications 1. Mechanism of action of a-adraaergic receptor blocking agents in angina pectoris. Wilson, Brooke, Lloyd and Robinson (1969). Brit.Med.J. 4, 399. 2. Effect of ergotamine and ergomettine on forearm venous compliance in man. Brooke and Robinson (1970). Brit.Med.J. 1, 139. 3. Iron absorption and pyrexia. Be:esford, Neale and Brooke (1971). Lancet 1, 568. 4. The influence of malnutrition on the post-prandial metabolic rate and respiratory quotient. Brooke and Ashworth, (1972). Brit.J.Nutr. 27, 407. 5. Iafluence of malnutrition on the body temperature of children. Brcoke (1972). Brit.Ned.J. 1, 331. 6. Hypothermia in malaourished Jamaican children. Brooke (1972). Arch.Dis.Childh. 47, 525. 7. Therssn•egulatory instability in kernicterus. Brooke (1972). it.Znd.Med.J. 21, 253. 8. A simple metabolism csambar allowing aceurate determinations of evaporative water loss in large babies. Brooke (1972). M.Ind.Med.J. 21, 202. 9. Specific dynamic action in malnutrition. Ashworth, Brooke and Watarlow (1972). Proceedings of the first international symposium on energy balance in man (ed. Apfelbaun and Mlller), Paris, Masson. 10. Pasting hypoqlycaemia due to increased glucose utilisation and inappropriately high j++g,l in. Rerr, Brooke and Robinson (1972). Ped.Ras. 1 399. 11. The metabolic rate of malnourished children. Brooke and Cocks (1973). J.PhysioL. (LOnd.) 231, 18P. 12. Evaluation of a method for measuring urine temperature. Brooke, Collins, Fox, James and Thconton (1973). J.Physiol. (Lcad.) 231, 91P. 13. Rasponse of malnourished babies to cold. Brooke, Harris and Salvosa (1973). J.Physiol. (Lcnd.) 233, 75. 14. Thermal insulation in malnourished Jamaican babies. Brooke and March (1973). Arch.Dis.Childh. 48, 901. 1S. Response of malnourished babies to heat. Brook. and Salvosa (1974). Arch.Dia.Childh. 49, 123. 16. The importance of routine urine cultures in malnourished children. Brooke and Xerr (1974). J.1rop.Pediat. 19, 348. 17. Resting metabolic rate in malnourished babies in relatio,z to total body potassiun. Brooke and Cocks (1974). Acta.Paed.Scand. 63, 817. 18. Sarum and liver triglycerides in malnourished Jamaican children with fatty livrs. Flores, Seakina and Brooke (1974). Am.J.C1in.Nutr. 27, 610. 19. Measurements of deep body temperature from the urine. Fox, Brooke,Collins, Bailey and Healey (1975). J.C1in.Sei..fol.Bic1. 48, 1. UO ;4

I 350 7 20. High energy feeding in immature infants. Brooke and Alvear (1976). Nutr.Metabol. 20, 165. 21. High energy feeding in protein-energy malnutrition. Brooke and Wheeler (1976). Arch.Dis. Child. 51, 968. 22.Hiqh fat feeding in immature infants. Hrooke and Alvear (1977). Nutr.Metabol. 20, Suppl. 2, 70- 23. influence of acidosis on energy absorption in immature infants. Brooke (1977). Arch.Dis.Child. 52, 809. " 24. Specific dynamic action in infants of low birth weight. Brooke and Alvear (1977). J.Physiol. 275, 54P°. 25. Postprandial energy expenditure in small-for-dates and immature infants. Alvear and Brooke (1977). Acta.Paed.Belq. 30, 249. 26. Fetal growth in different racial groups. Aivear and Brooke (1978). Arch.Dis.Child. 53, 27. 27. Energy cost of growth in healthy iaature infants. Brooke and Alvear (1978). Acta.Paed.Belg. 31, 169. 28. Loss of energy during continuous infusions of breast milk. Brooke and Barley (1978). Arch.Dis.Child. 53, 344. 29. Energy retention, energy expenditure and 5rowth in healthy immature infants. . Brooke, Alvear and Arno]d (1979). Pediat 3.es. 13, 215. 30. Which 'small-for-dates' infants are malaourished7 Brooke and Butters (1979). Areh.Dis.Ch1.1d. 54, 161. 31. Stools in infancy: frequency, weight, water and energy content. Lemoh and Brooke (1979). Arch.Dis.Child._ 54. 162.._, ._ 32. Circadian rhythms of inelatoain and cyclic-AMP in neonates. Evans, Carter, Brooke and Smith (1979). Arch.Dis.Child. 54, 161. 33. Effects of nmolementarY vitamin D during pregnancy in Asian women and their . uacanv. Brooke, Bone, Brown, Carter, Maxwell and Robinson (1979). Arch.Dis.Child. 54, 971. i inf ~1 l t l b ancy. norma oo s n s 34. Frequency and weight of a Lemoh and Brooke (1979). Arch.Dis.Child. 54. 719. . _ ._ 35. Changes in human fetal mineral metabolism associated with maternal vitamia D supplementation. Brown, Brooke and Cleave (1980). Biochem.Soc.Trans. 8, 136. 36. Food and the fetus and neonate. Brooke (1980). Proc.Nutr.Soc. 39, 17. 37. The ingestion by pregnant women of substances toxic to the foetus. Evans,Brooke & West (1980). Practitioner 224, 315. g 38. vitamin 0 supplements in pregnant Asian women: effec s on calcium status and fetal growth. , ., ,2.( Brooke, Brown, Bone, Carter, Cleave, Maxwell, Robinson and :,tinder (1980). ,ra~, Br.Med.J. 1, 751. 351 8 39. Energy metabolism in the neonate and the Brooke (1980), in Topics in Paediatrics 2, NL Tunbridge Wells: Pitman Medical. 40. Growth in British Asians: longitudinal c Brooke a Wood (1980). J.Human.Nutr. 34, 355. 41. Lysozyme, IgA, Lactoferrin and carbonic a of preterm and term infants. Brooke, Carter, West & Wood (1980). Atch.Dis 42. Vitamin D and plasma magnesium in pregnar. Brown, Brooke & Haswell (1981). C11n.Chim.Ac 43. Comparison of protein concentrations and term mothers. sibberd, Brooke, Carter & Wood (1981). J.Bum Review Articles, Chapters etc Is National Dried Milk really dangerous? Srooke (1976). Nutrition and Food Science. Znfant feeding - the perennial problem. Brooke (1978). Practitioner. 221, 314. 'When can amniocentesis help? Brooke (1978). Drug and Therap.Bull. 16, 81 "C:anges at Birth and Physiological Maturation 'iter Childhood". Brooke (1980), in "Development,4Yowth and Ag 7itamin D supplements in pregnancy. Brooke (1981). J.Maternal and Child Health. Corresoondence containinq oriqinal scientific Fat absorption from two infant milks. Brooke (1976) . Arch.Dis.Chi]d. 51, 159. =:.argy content of milks fed to infants. Brooke and Barley (1976)_ Lancet, 2, 799. ~ffect of smoking on fetal growth. Alvear and Brooke (1977). Lancet, 1, 1158. 7:caain D deficiency in Asian immigrants. Brooke, Brown and Cleeve (1979). Br.Med.J. : ;=tam.f.n D supplements in Asian women. 8roo4e and Brown (1980). Br.Med.J. 1, 1054.

® .C Y 351 39. Energy metabolism in the neonate and the malnourished child. Brooke (1980), in Topics in Paediatrics 2, Nutrition in Childhood, ad. Wharton, Tunoridqe Wells: Pitman Medical. 40. Growth in British Asians: longitudinal data in the first year. Brooke & Wood (1980). J.Human.Nutr. 34, 355. 41. Lysozyme, IgA, Lactoferrin and carbonic anhydrase Levels in the milk of mothers of preterm and term infants. Brooke, Carter, West & Wood (1980). Atch.Dia.Child. 55, 652. 42. Vitamin D and plasma maqnesium in pregnancy. Brown, Brooke & Haswell (1981). Clin.Chim.Acta (in press). 43. Comparison of protein concentrations and energy in breast milk from preterm and term mothers. Hibberd, Brooke, Carter & Wood (1981). J.Human.Nutr. (in press). Review Articles, Chapters etc Is National Dried Milk really dangerous? Brooke (1976). Nutrition and Food Science. Znfant feeding - the perennial problem. Brooke (1978). Practitioner. 221, 314. 44, 2. t4ien can amniocentesis help? Brooke (1978). Drug and Therap.Bull. 16, 81. "Chanqes at Birth and Physiological Maturation in the Newborn Period and During later Childhood". Brooke (1980), in "Developsent,Growth and Ageing", ed. Carter, Londona Croom Helm. Vitamin D supplements in pregnancy. Brooke (1981). J.Maternal and Child Health. 6, 18. Corresoondence containing oriqinal.scientific data. Pat absorption from two infant milks. Brooke (1976). Arch.Dis.Child. 51, 159. Energy content of milks fed to infants. Brooke and Barley (1976). Lancet, 2, 799. Effect of smoking on fetal growth. Alvear and Brooke (1977). Lancet, 1, 1158. Vitamin D deficiency in Asian immigrants. Brooke, Brown and Cleeve (1979). Br.Med.J. 2, 206. Vitamin D supplements in Asian women. Brooke and Brown (1980). Br.Med.J. 1, 1054. B

352 Clinical papers and correspondence Recurrent meningitis. Brooke, Ford and Mackintosh (1970). Brit.Med.J. 4, 218. Nalnutrition and body temperature. Brooke (1972) . Brit.Mad.J. 2, 164_ Lscherichia coli meningitis and congenital tuberculosis in the same intant. Brooke, Dow and Hanid (1977). Iancet, 1, 599. Unusual cause of birth asphyxia - & posterior lingual polyp. Brooke, Nesbitt and Wilson (1977). Brit.Med..J. 1, 777. Makinq tiny infants lovable. Brooke (1980). J.Hat.rnal and Ch1d.Slth. 5, 116. Cazttraindications to iasmizatioa. Brooka (1980). Br.1Mad.J. 2, 58. Book Reviews "A colour atlas of paediatrics" (Dynski-Klein). Br.J.Obst.f,ynaecol. 82, 767. 'Proteia-energy malnutrition". (Alleyna, Bay, Picos, Stansfield & Whitehead). Arch.Dis.Child. 52, 595. "Pediatric nutrition in developmental disorders". J.Human.Nutr. 34, 64. "HUman Growth" vol.1,(Fal)mer & Tanner). J.Human.Nutr. 33, 239. "Human Growth" vol 2.(Plakner & Tanner). J.Human.Nutr. 33, 303. "Human Growth" vols. 1 &2 (Fal)mer & Tanner). Lancet 1, 1169. "Human Growth" vol.3. (Palkner & Tanner). Iancet 2, 775. 10 (Palmer & Ekvall). ., tY 353 STATEMENT OF BARBARA I am Barbara B. Brown, form ^ysiology, Veterans Administration H -a!ifornia. I received mv Ph.D. in P .'niversity of Cincinnati College of M 3 _vears research experience, primari ^harmacology, psychopharnacology, neu -.`.ysiology. I began my research acti .:.armaceutical firm of The (+Tm. S. Mer ,rrill-Richardson) and later became ,-srnacolcgy. After leaving Merrill, rarmacologist at Riker Laboratories - nsulting Neurophysiologist at Psyc: Laboratories. I was also an associa- ?.armacc-ogy at the University of Ca ..c_ences in Los Angeles and at the D, 4.•_aan Behavior at the University of ._cturer at the Department of Psychi =xperiential Physiology Research at :.ras one of the pior.eers_ in the dev =:o`eedback. In the past few years, activity has centered around attempt ^-ental activity (brain information F 1-•d illness. To date, I have pub liE --.eoretical articles on this subject 11