Tobacco Documents Online

My name is Rodger L. Bick; I am the medical director of i San Joaquin Hematology & Oncology Medical Group. I am also assistant professor of medicine, specializing in hematology I medical oncology, at the School of Medicine of the UCLA iter for the Health Sciences in Los Angeles. I am on the :nical faculty for hematology and oncology of the Wadsworth a. Hospital in Los Angeles, and hold adjunct teaching positions the Wayne State University Specialized Center for Thrombosis ;earch in Detroit and at the Wesley Medical Center and _versity of Kansas Medical School in Wichita. I received my medical degree from the University of .ifornia at Irvine School of Medicine in 1970. In 1973 and '4, I was the Director of the Hemostasis/Thrombosis Research -oratory, Chief of Hematology/Medical Oncology, and Director of '.ical Education at the Rern County General Hospital in ersfield, California. From 1974 till 1977, i worked for the Area Hematology Oncology Medical Group and Bay Area atology Oncology Clinical and Research Laboratories in Santa .ica. From 1980 to date, I have been an associate professor of ied Health Professions and of Nursing and Health Sciences at ifornia State University in Bakersfield.

294 I am a member of numerous professional societies, s including the International Society on Thrombosis and Haemostasis„~ ;;>£ and the American Society of Hematology, and serve as editor for -- . . several journals in my field. I have written over 100 published " articles on various aspects of the field of hematology. I have long been interested in the subject of blood coagulation and its possible relationship to heart attacks and': cardiopulmonary disease in general. Recent reports have appeared"; in the literature describing alleged isolation and biological'l properties of certain brown pigments from cured tobacco leaf,., cigarette smoke condensates, and saline extracts of smoke. These pigments have been generally referred to as "tobacco glycoprotein" (TGP). Becker and co-workers have reported tha*_, TGP produces allergic skin reactions, induces the formation of , antibodies, and activates early clotting factors. Based upon these rather simple experiments, with respect to early blood clotting factors, Becker and co-workers have drawn far reaching conclusions that TGP therefore must also activate the remainder of the clotting system, clot lysing system, and complement system. However, there is no evidence for this sequence of events in either the Becker articles or in subsequent work. In spite of this lack of evidence, these authors have hypothesized that these possible sequential pathological events represent the ci 295 pathophysiological link betweer cardiopulmonary disease which has be To investigate more carefu al., our group, in collaboration wi by the previous published methods c 7roup found that the final produc nrocedure of Becker contains an contaminant that is introduced by f .noears to be a side product of the ..sed to form the gels for sepa -on*_aminant, polymethylmethacrylat orthopedic and dental surgery and t been implicated in allergic reactio •.:e subjected the contaminant to th clo*_ lysing, complement, and kinin Eound that the contaminant complex early coagulation Factor, Factor XI completely erroneous impression th However, it was found to have no ac currently used by the Bureau activation of the blood clotting sctivation of numerous of the earl :.ikewise, there was no activation c effect on the complement system, -3-

295 pathophysiological link between cigarette smoking and cardiopulmonary disease which has been reported. To investigate more carefully these claims by Becker et al., our group, in collaboration with Dr. Stedman, extracted TGP by the previous published methods of Becker and co-workers. Our group found that the final product obtained by the isolation procedure of Becker contains and consists primarily of a contaminant that is introduced by the methods of separation and appears to be a side product of the photo-polymeri2ation reaction used to form the gels for separation. (Relatives of this contaminant, polymethylmethacrylates, are widely used in orthopedic and dental surgery and traces of these compounds have been implicated in allergic reactions and clot formation.) When we subjected the contaminant to the aforementioned coagulation, clot lysing, complement, and kinin generation assay systems, we found that the contaminant complexed with small amounts of an early coagulation Factor, Factor XII, giving the superficial and completely erroneous impression that activation was occurring. However, it was found to have no activity on thrombogenic assays currently used by the Bureau of Biologics for detecting activation of the blood clotting system. Nor was there any activation of numerous of the early coagulation Factors tested. Likewise, there was no activation of the fibrinolytic system, no effect -on the complement system, and no effect on the kinin

generating system. Further, we found that there was no effect of this contaminant on the normal clot inhibiting proteins found in human blood. Our studies strongly suggest that TGP isolated by the general published procedure of Becker and co-workers consists of a contaminant which is introduced during the separation process and contributes to, or more likely, is entirely responsible for the biological activites noted by Becker and co-workers. The presence or absence of a substance in tobacco smoke and certainly unproven. It is obviously of importance to examine the significance, if any, of tobacco glycoprotein; however, a good deal of controversy does exist and it has been impossible to duplicate previous findings. In this one instance it appears that erroneous and superficial observations have led to far reaching hypotheses which cannot be confirmed by carefully performed studies. This author's plea would be for adherence to confirmed scientific fact, rather than emotion, in attempting to study and delineate the biological effects, if any, of cigarette smoking on the blood coagulation complement or kinin systems. My own research and review of the scientific literature lead me to the conclusion that whether and how smoking might cause heart attacks or cardiopulmonary disease remain open questions. 297 can Fra-:cisco, r•a;if-rr.-'s rit.a] S'a s: arried ._....er x'-_a Ca:if , ' S a_ata: ~ni.=rsi,y of : 3''0 - a et .. _-:r: . cs. "'c.•-ia 't .. n. eg c, a n. .'~!'y':911 -'' .]'2,,~= p: Cai:`ornia a-.d iil 'C; p_ t9t6 - Sa, C `307 - - =:d ;' .'.d icg r '.aic` r.e, i367. • -°,rt•!i r ar~i: -o -.2AiCai .-'.,i ...: -:5 -... 7a1 r ._<e_rch __ ~ %-1iy 1973 - ',;y :9.'4. :'or of ',, a] d at:cn: Ker~ Cc er; 1973 -'day 1974. %I

297 San Fra-:ci.sco, r_a;if_rr'_s .:rri?d S!21/;2 :;N : "r. -_ry: . -cra .._,..rec .. ul, fa;if-•.._`a °'7h cC` ;1, .ra, ,..._ .:-is :.<i:y,?f i: et _.. - . . _ .. ._-_~. i;v 'r~ 2 9'l n - .r-:1 = y: ~,_ly i9 1' e^:?;2, .__._.:.:.p: ol CLa _-cer .or ... - a 9_..:.: , Cali__rnia __ .'_.i1 ife7c ..;,by -'li.: ...p: 7g'6 - Sa'~?c-.lr ;?'•6. d1' _._. 91. `I " _, 1 .i a L?St -vt .-.._._ _ ~ .. rs r :.{ b7. i', -1 Jf adi: ne , _ .. ay _d `or ... . ..._:ng ._ _e.ch, _ 4z 1 cz <dici.e, 'sS. ?o _-.._or :i----'-- .. .-1 . . .zr.•, ....r -.y --.:=a1 7S• ° - ... e, -..S '-.t __._r,e. _ -:_t ee c•r :.; a zl - < ital, ?z'< d, Caii.cri;a, C~iefr -e~_tclc e?:cal C^ :y, }'=:n _ ty ._ : .. , a1, .. c d. =slSfor.^ia, .'•uiy 1973 - `ay :9.'4. D::•r tor of . dical Ed:;cati.m: Ke:1 C: z%ty Ca:iEornia, Ju1y 1?'3 - 51ay io-4. trA T

298 r 29 CL'3RI~_~l!".d VITAE: -G:3 L, °'CK, 'd,D. - Ts (cO7t.): !f_^l,cr: Cancer St. 7clin's 1`Er: i.~<__cclt C__':i?tee, S S.:_3 _3 tl, .-.a _'..i•a, l.~___ 2:.Jr ?:,il•d, `;a.^3 .cnica "`tr: .._.cC'r C;:_•ittee, Fa:.ta M".'1'_ COrjl.`ltr-lt: . "b?rZa F.'-,_J1Cy-y Ca: er, =a. Fc_ id`ng D1:Ectar: C-c~1C5y Unit, 32.n.t3 ... '3 ,:. _ _.31, " .-_:3, '._A Director: ional ?le-:stas.s . .-. .:sis Sc .rs ; " - _ -r oa CcRrin... .n.g ;-t.'.dic31 Fd'.:C3t2^n, nE_-._-1 $cC .ty Of 1.171_a1`- -'S4-`s 'e" cal Staff: BCL> "e. ar for the Fes ::7 _,s =a . r c a l Staff: Sa :ta `;c ca . ital -.- _ caI C~-c r . . . ...._ ._4 '.al Stsff: St. sri-l -9 att!, er, zta :A .s?s..,rth ,..,_--_ _ cal St rf: Gr- ter 3a.ersfield . ar`s1 He_ a1. . -'.:•.al ^ff: _s:t _.3•:, iZ C:;-~_- :y -._ al, _°.aff: ascy ~csi:i:al, -_,~_-__~?•i, C31if.-.rr;3 Ch C=.,,_er Cc-7pit. ~;a -;_-;n s•_.=a: "W.-or ".:ard, Inc. Jo e ia F: Ca::io:ria f IiI P•-o;e..t, I_:_sa cf Co-I cr: AT C... . -+t: . ?rri 1 `.~r • _lacco . arch "-, cS and Rnt aa_r Re. _•w l.i.-.. .51 K5.1 Group Clir-ca1 in•-._ -atcr: 'zericxn DADE .:•iic.31 ._. s. .. C-'_ter ~le•:tr.::;ics 2c3,d or rs, 'tericls .ris: r;' C . ~oclety of C1:-~ica1 ~:~.._'_ogists. E`C'iLTY ;??. c• ,t r_o~`_sor f ic1:e {e-, o'.' y,'` .'ic31 1, t_-f ..ed'•.ie, S ol of lr„ic:-:e, ;iCL4 .,r e -.--..- -e . , .5 '-.nsa•~s, Cal:f-rnia C1i-ical -"zvity V.A. •- .z', . _ .: Ca' -nia =te essar of ._-_ d 9~a_ih r .sfie_i, California v C1=n.._:1 k<_sociate .^- .fesscr of -_ , '. . ..-;a ' _. :ersity, SaT:ersfield, C4 :,61-52 ct soc:ate rofessor cf `-_ '*%s`z"s~, r ~ _ ^~ • e \---' ~S: g;n (rrs .ge :o ., ,~e+o =: .:>flc'3 _'d I .-._. . =.el . _ . . . . : : i l • ~l'-:,LV: _ _ . ' C c l ~ _ . cr a-] .._ -- `~ • - - a~.~_;1 cc ^ol, itiictlta, i:`^., as -s = = ' -~`r L. in 3ab:e.sfield,C,1._~ ia for .._-...-as__ _ - ?4:CATE ."-=TCTICE: Say Area ?e-atolc;y ^ncology ;ted_ ,1 . .:p _-d ay _.=a . _ • ~' :3Y Clinical and Sesea:ch '_aboratcrizs, S:::ta '.:rica, ''_l_`-:-ia,~_3 1- i377. '•?edical Director: California C3ag'iiaticn ..a,..-Ic., __ :=__.•id, CA. -'- :S -~ t.•,)1 c.'~ .._- in c,~JEr 1477 'O ~ P_ E:tt. ~T"TS ?=pC'_n2D: A. A:•Ethod for t.`.e ._ ~e Scalz <. c. ai of 3. A Yot~:d f~r the Sczle Fract_c:.at: Sh Fa,~tor VIII C,ce,t t? C. 4:•'et: ~d for t':e 1=rge Scale 'r;ctic-at' :... -. , LF. ==f ={~Ti;1j• . . _`or Fe- --.ars -k, 3r, ;4C, rear --n, ~.C, ct'_?it, R: 2ts of r _ v _:..a ..v~ c_r±al 9 t' e t _zl y ~.t e. = e L•: ° ,.. g-.. _ -_69. ?.C, E• -i.c -_- , :k 3L, ..::~=.t, J: S. iss --- - -ng --"- ~--2C a----~-• =i ;r -.'.ar,`_ron, E: ZC c-,ach to the d:.- is of b';e `.1• _- •.._ r i,, 1:23, iy72 ' ~L, 31s. _ PC, and S!•ar.1-ca, E: L tic =ctisity ;n ar t_ aez_di-1 i.:f, . J. CI`n. :sth. 57:3:9, 1972. G7 :_. etr; `_, ,.iosy 39:213, 19-2. .alt, J, Scara:.`3rst, R: A CJ ;' _>:n Jf a..., t ~~1 _S for }ie,-3tltls. ='.^Se, :972. rr .~_ i^-_r ~C ,'_s-- t, N: cl ? r3 f_ st`°. tctaI ca-'_ - J. - :569, 1973. ~ _ick, RL: eriiSr'_:ol sis in eirr.`.osis -~. J. Gast_:,e-.,aro_osy 50:_50, i9-3. 95-077 0-82-20

299 CG ;11',.?f 6IT.- ?RICA?E P;..CTICE CQon*.): San ,'_a-.ain ia \,~:e-ber 1977 to -ire_ent. FATE.`:TS P=OC_wD: A. B. A *Set~ od `or t:`.e ; -e Scsle A :.et':od for the L-ge y- aie igh Pot -=y FactorV[II ' .- C. A:'e*_`.-~d for .' e rge ccale --sctic;:'t--n .. : . .t___=`_:z _ :3 . .. . . , LF. r;'31--.>7P;\S: Co-S'i':r for Sea -'.zrs _a 2ick, :lt, Giolli, ;iC, R: . . e f r e c t s o f _ - - Y - . . a . . . - - ~ -d tie .l sl of = ..:eLr.:.s- ..^s .ats. 3i,.•k, RL = .-P, RC, •.,.eh_}n E: 1 -'. . t5 C i _.ltia ~ . 1970. 'ick, RL, J: c!, RT ron, E: A ., .:c to t`e d'._, :-s .,t 9:23,1972 :'ed:~CO~'tteTJ r Ezc~; BL, 3`sti•,p, aC, and i. Fi'?r: oI}tic acti•:ity ;n ac:t: .r. J. CI`1. ~..th. 57:3E9, 1972. -_ck, :ZL, '',=-;scn, C,_ etrics-G;-.c- 3y 39:213, 19=2. ?ick, PL, :. .alt, J, S,hza: orst, -a: - atralia ..,r._sei: A coz.;sri_:n ot =._. at high r:sk •`^.r he-=-titis. 1.,. J. C L'n. .^_be, :9-2. . :tc, iL, l^.r, i[ _,_t -<r, N: J.'Csr___ as. ?--,rg. _ :SE9, 1973. Pises, P, ?ick, RL: HyparfiSrirol>sis in cirr.`,asis am. J• Gaetr:,e:.tsro'_o;y 50:=00, :y 3. 95-077 0-82-20

300 YIT1.c: r':3LIC.TiC':S ^t.): B' ct RL 3is`op ?C Tse, D, -. _..broa, E: F:ctor V: A sspiifiel o:je staae --say :.si-g ;_. -.__-_c -:,1, 3.itr. 2. Path. 15?:511, I:'3 Sick, RL, =.da^s, T, Goi.";:ert, LS: A PreV1oUS L.-Y. Cr0't:-d C'33U1atiCn "liyies-StcCen s~T.droire. . . Ci-.n. 7,es. 21:264, 1973 Si.k, RL, Sc..-alhorst, WA: az zbo:ytic *_.`:erapy :ai.h = _.a _.. t_ .-..,_, t Va=c. Surg. 8:152, 1974'. 4L: Sick , -:d t_ca..ernt .7ad. C^'.~;:te_po_nt 6::8, 19+4. 3i ck, T: 3i. ?cc4 ±L, . . _~, T, a-.i , __tk, K: S.::gi.-1 _ 'ostasis . th a J.A.?L A. 2:9:153, 1974. Bi •k n s T LS: :e : ..shcs-Sto': ea i-itr. ._t4. 3d. 153:.:0, :9'4 Blck, ;L: Fi' ri^oiytic ~=-tia1 in ._ra :'~. ...th. 3d. lii:-07, 1974 Sick, RLN, '.4, C:.:°ord, ?late_rt f:-,.ti.n _ iitSes in `s. Circ'ji.,.__n =3. •,k 17 t c., ,.st 77 in -.r:rx ~.+c_r.-..te: use in s of c.`. ic :;;er '.ise=_se. Am. J. D:;?s. Z0:'=1, 1975 .-_t RL, C-:w..:d, L. : .-.-_n, , _.-s, T, Sick, RL, 5:` __? rst, h'R, L: 3L:_.a a=sri-s:ad r.tr -ascui:r c_ _on T.saf' si_•n, 16:561,- 19'6 301 C_aRICU'_:^a VITAE: ^;;9LIC:TICYS (cont.)• Bick, RL, Adams, T, Schmalhorst, WR: Bleeding times, platelet adhesion, and aspirin Am. J. Clin. Pathol. 65:69, 1976. Bick, RL: Alterations of hemostasis associated with card Thronb. Res. 8:285, 1976. Bick, RL: - Adriamycin and fibrinolysis. Thromb. Res. 8:467, 1976. ~' Bick, RL, Fekete, L. Murano, G, Wilson, NL: Duano"tycin and fibrinolysis. Throc.b. Res. 9:201, 1976. , - Bick, RL, Fekete, L,.Kot'acs, I: A new two-stage functional assay for antithroml clinical and laboratory evaluation. Thromb. Res. 8:745, 1976. Wilson, WL, Andrews, NC, Frelick. RW, Nealon, 1 Preli^inary re_ort on the use of CC?.U (\SC-790: Hexamethvlmelamine. (,tiGf.-]~R75) in careino^;a_of Cancer Treat. Rept. 60:269, 1976. Fe;ete, LF, Bick, RL: Laboratory modalities for assessing hemostasis Semi&ars in Thromb. and Hemostasis 3:83, 1976. Bick, RL, Dukes, ML, Wilson, WL, and Fekete, LF Antithrombin III as a diagnostic aid in dissemi Thromb. Res. 10:721, 1977. Bick, RL: Complement levels in disseminated intravascular Am. J. Clin. Path. 68:93, 1977. Bick, RL: Alterations of hemostasis associated with malig diagnosis and management. Sem. Thronib. and Hemostasis, 5:1, 1978. -5- -4-

301 C,?.HICu'!J!( 'dIT.;E: L. 3'.CK, `d, D. PtiBLIUTIC`S (ccnt.): Bick, RL, Adams, T, Schmalhorst, WR: Bleeding times, platelet adhesion, and aspirin. Am. J. Clin. Pathol. 65:69, 1976. Bick, RL: Alterations of hemostasis associated with cardiopulmonary by"2ass. Thromb. Res. 8:285, 1976. Bick, RL: Adriamycin and fibrinolysis. Thremb. Res. 8:467, 1976. Bick, RL, Fekete, L. Murano, G, Wilson, WL: Duanomycin and fibrinolysis. T.:romb. Res. 9:201, 1976. Bick, RL, Fekete, L,.Kovacs, I: A new two-stage functional assay for antithrombin III (heparin-cofazter) clinical and laboratory evaluation. Thromb. Res. 6:745, 1976. Wilson, WL, Andrews, NC, Frelick: RW, Nealon, TF, Bick, RL, :dams, T: PreliTinary -eport on the use of CCAU (NSC-79037), Adrianycin (NSC-123127), and Hexamethylmelamine (NAC-13R75) in r,arrinoma of the lung. Cancer Treat. Rept. 60:269, 1976. Fekete, LF, Bick, RL: Laboratory modalities for assessing hemostasis during cardiopul^cnary bypass. Semiaars in Thromb. and Hemostasis 3:83, 1976. Bick, RL, Dukes, ML, Wilson, WL, and Fekete, LF: Antithrombin III as a diagnostic aid in disseminated intravascular coagulation. Thromb. Res. 10:721, 1977. Bick, RL: Complement levels in disseminated intravascular coagulation. Am. J. Clin. Path. 68:93, 1977. Bick, RL: Alterations of hemostasis associated with malignancy: etiology, pathophysiology, diagnosis and management. Sem. Thromb. and Hemostasis, 5:1, 1978. -5-

302 CURRICULUM VITAE: RODGER L. BICF:, ?I.D. PUBLICATIONS (cont.): Bick, RL: Antithrombin III: diagnostic and therapeutic implications. Presented at the Annual Blood Coagulation Symposium (•lanual), J. Penner, (Ed.) Ann Arbor, Michigan, 1978. Bick, RL: Disseminated intravascular coagulation and related s,,ndroaes: etiology, patho- physiology, diagnosis and management. Am. J. Hematol. Vol. 5, 03, 265, 1978. Bick, RL:' Vascular disorders associated with thrombohemorrhagic phenomena. Sem. in Thrombosis and Hemostasis, Vol. V, No. 3, 167, 1979. Nalbandian, RM, Henry, RL, and Bick, RL: Thrombotic thrombocytopenic purpura: An extended editorial. Sem. in Thrombosis and Hemostasis, Vol. V. \o. 4, 216, 1979. Bick, RL, Fekete, LF: Cardiopulmonary bypass hemorrhage: aggrevation by pre-op ingestion of anti- platelet agents. Vascular Surgery, Vol. 13, No. 4, p. 277, July-August, 1979. Bick, RL: Monitoring heparin therapy. Diagnostic Dialog, Vol. I, \o. 4, August, 1979. Bick, RL, Marcum, JD: vo., Yalebrand's disease. Diagnostic Dialog, Vol. 1, No. 5, November 1979. Bick, RL: Monitoring heparin therapy. Kern County Medical Societ,v, The Bulletin, Vol. XXVI, No. 12, 1979. Bick, RL: In vivo platelet inhibition by piracetam. Lancet, Vol. II, p. 752, 1979. Bick, RL, Bick, MD, and Fekete, LF: Antithrombin III (AT-III) patterns in disseminated intravascular coagulation. Am. J. Clin. Path. 73:577, 1980. -6- 3( PUBL?CATIC]S (cont.) Bick, RL: Malignancy's Effect on Hemostasis: Complex Diag. Dialog, July 21, 1980, Vol. 2, No. S. Bick, RL: Malignancy's Effect on Hemostasis: Part II Diag. Dialog. September 8, 198A, Vol. 2, No Bick, RL: Dissemir.ated Intravascular Coagulation: A C: Annals of the New York Academy of Sciences, Henostasis. Bick, RL: Hereditary Hemorrhagic Telangiectasia and D: A `:e» Clinical Syndrome Annals of the New York Academy of Sciences, 4emostasis. Bick, RL: Disseminated Intravascular Coagulation (DIC; Diagnosis Practical Cardiolugy, 7:145, 1981. Bick, RL: Disse^:inated Intravascular Coagulation (DIC' stanifestations of Related Syndromes. Practical Cardiology, 7:152, 1981. Bick, RL: Clinical Significance of Fibrino(geno)lytic Lab-Lore, 9:683, 1981. Bick, R.L. Hereditary Hemorrhagic Telarigiectasia and Di A New Clinical Syndrome. Vasc. Surg. 15:394, 1981.

= L`L?f v iT:E: PUBLICATIC\S (cont.) Bick, RL: Malignancy's Effect on Hemostasis: Cor..plex questions finding answers. Diag. Dialog, July 21, 1980, Vol. 2, \o. 5. Bick, RL: Malignancy's Effect on Hemostasis: Part II. Diag. Dialog. September 8, 198,0, Vol. 2, No. 6. Bick, RL: Dissemir.ated Intravascular Coagulation: A Clinical/Laboratory Study of 48 patients. Annals of the New York Academy of Sciences, 370:843, 1981 - Contributions to Hemostasis. Bick, RL: Hereditary Hemorrhagic Telangiectasia and Disseminated Intrarascular Coaguiation: A New Clinical Syndrome Annals of the New York Academy of Sciences, 370:851, 1981 - Contributions to Hemostasis. Bick, RL: Disseminated Intravascular Coagulation (DIC). Part I. Pathophysiolcgy and Diagnosis Practical Cardielugy, 7:145, 1981. Bick, RL: Disseminated Intravascular Coagulation (DIC). Part II: Therapy of DIC and the Manifestations of Related Syndromes. Practical Cardiology, 7:152, 1981. Bick, RL: Clinical Significance of Fibrino(geno)lytic Degradation Products (FDP) Testing Lab-Lore, 9:683, 1981. Bick, R.L. . . Hereditary Hemorrhagic Telarigiectasia and Disseminated Intravascular Coagulation: A New Clinical Syndrome. Vasc. Surg. 15:394, 1981.

Cl.°.-.RICULL^f CI.T..E: BCr:KS:'CRaPTERS;`:i~ .aLS: Sick, RL: Editor and '!ain .cuthor Modern Concepts and Evaluations of Hemcstasis ~-:nd Fhr,=bcsis American Society of Clinical Pathologists Publicstion, Chicago, I1'__;ois, 1975 (.G0 pa3es' Guest Editor: Seminars in Hemostasis and I'hrombosis, October 1916. Alterations of hemostasis associated with cardiepul^enary bypass; pa:`.crh>•<_iology, prevention, diagnosis and management. R.L. Bick, Chapter 2: Laboratory modalities for assessing ?,emostasis 3uring cardi:pul-:.nary bypass. Sick, RL and Fekete, LF. - lick, RL: Editor and Main Author Difficult Diagnosis Problems ip Hemostasis and Thrombosis American Society of Clinical Pathologists Publication. Chicago, Ill. 1976 (300 pages) RL: Bick , Current Concepts of Hemostasis and Thrombosis: Clinical and Laboratory Evaluation American Society of Clinical Pathologists Publication. Chicago, I11.. 1976 (600 pages)- Bick, RL: Recent Concepts and Developments in Evaluating Disorders of HeTcstasis and Thrombosis American Society of Clinical Pathologists Publication Chicago, Ill. 1976 (700 pages) Bick, RL: Bleeding and Thrombosis in Malignancy. Chapter in Care of the"Cancer Patient. Tom Nealon (ed.), W,B. Saunders, X976. Bick, RL: A systemic approach to the diagnosis of bleeding disorders. Chapt. 4 in Basyp Concepts of Hemostasis and Thrombosis. Murano, G. and Sick, RL (e=s.) CRC Press, Boca Raton, FL, 1980. Bick, RL: Vascular disorders, Chapt. S in Basic Concepts of Hemostasis an3 Thrombosis. Murano, G. and Bick, RL (eds.) CRC Press, Boca Raton, FL 1980. Sick, RL: Hereditary plasma protein disorders. Chapt. 7 in Basic Concepts of Hemostasis and Thrombosis. Murano, G, and Sick, CRC Press, Boca Raton, FL 1980. RL (eds.) Sick, RL: Disseminated intravascular coagulation (DIC) and related syndromes, Chapt. 8 in_ Basic Concepts in Hemostasis and Thrombosis. Murano, G. and Bick, RL. (eds.) CRC Press, Boca Raton, FL 1980. -8- CL<4:LUL--'» VT:iE: BXKS/Cf..1PTER5/,%Lk\'UALS (cont. ) : Bick, RL: Primary hyperfibrino(geno)lytic syndromes, C:> Basic Concepts of Hemostasis and Throsbosis, CRC Press, Boca Raton, FL 1980. Bick, RL: Acquired circulating anticoagulants and defect protein disorders, Chapt. 10 in Basic Concepts of Hemostasis and Thrombosis, '; CRC Press, Boca Raton, FL 1980. Sick, RL: Alterations of hemostasis associated with mali Basic Concepts of Hemostasis and Thrombosis, ` CRC Press, Boca Raton, FL 1980. Bick, RL: H,vpercoagulability and thrombosis, Chapt. 13 Basic Concepts of Hemostasis and Thrombosis, ' CRC Press, Boca Raton, FL 1980. Bick, RL: A.nticoagulant and antiplatelet therapy. Chapt Basic Concepts in Hemostasis and Thrombosis, ' CRC Press, Boca Raton, FL 1980: Murano, G. and Bick, RL:. Throlnbolytic therapy, Chapt. 15 in Basic Concepts in Hemostasis and Thrombosis, CRC Press, Boca Raton, FL 1980. Bick, RL: Disseminated intravascular coagulation and re Perspectives in Hemostasis and Thrombosis, Fa and Brinkhous, tat (eds.) Pergamon Press, New York 1981. _ Bick, RL: Disseminated intravascular coagulation and re (textbook) CRC Press, Boca Raton, FL 1982. Bick, RL: Hemorrhagic problems associated with cardiac Textbook of Hemostasis and Thrombosis, Ratno Grune F, Stratton, New York 1982.

305 CL'RdICULI!?S \'II:E: 6.=°4 L. 6rKS/CYJ.P;ERS/NLk\'UALS (cont.): Bick, RL: Primary hyperfibrino(geno)lytic s;rdromes, C`:apt. 9 in Basic Concepts of Hemostasis and Thronbosis, .'•',..s.io, G. a;:d Bick RL (eds.) CRC Press, Boca Raton, FL 1980. Bick, RL: Acquired circulating anticoagulants and defective in ^alig:~.nt para- protein disorders, Chapt. 10 in Basic Concepts of Hemostasis and Thrombosis, 1Surar.o, G. and Bick, 2L ;eds.) CRC Press, Boca Raton, FL 1980. Bick, RL: Alterations of henostasis associated with malig-ancy, Chapt. 11 in Basic Concepts of Hemostasis and Thrombosis, )furar.o, G. and ?ick, RL (eds.) CRC Press, Boca Raton, FL 1980. Bick, RL: Hypercoagulability and thrombosis, Chapt. 13 in Basic Concepts of Hemostasis and Thrombosis, ~turano, G. CRC Press, Boca Raton, FL 1980. Bick, RL: Anticoagulant and antiplatelet therapy. Chapt. 14 in Basic Concepts in Hemostasis and Thrombosis, Murano; G. CRC Press, Boca Raton, FL 1980: Murano, G. and Bick, RL:. Throlnbolytic therapy, Chapt. 15 in Basic Concepts in Hemostasis and Thrombosis, Murano, G. CRC Press, Boca Raton, FL 1980. and Sick, RL (eds.) and Bick, RL (eds.) and Bick, RL (eds.) i Bick, RL: Disseminated intravascular coagulation and related syndromes, Chapt. in Perspectives in Hemostasis and Thrombosis, Fareed, J., Messmore, H, Fenton, J.W. and Brinkhous, IQ•1 (eds.) Pergamon Press, New York 1981. Bick, RL: Disseminated intravascular coagulation and related syndroc•es; in Preparation (textbook) CRC Press, Boca Raton, FL 1982. Bick, RL: Hemorrhagic problems associated with cardiac surgery. In Preparation, Chapt. in Textbook of Hemostasis and Thrombosis, Ratnoff, OD, and Forbes (eds.) Grune 8 Stratton, New York 1982. ~

306 C,RICULi:kf V'_TAE: BOOKS/CN_4PTERS/M4\UALS (colt.): Bick, RL: Hemostasis in transplantation surgery. In Preparation = for Textbook of Hemostasis and Thronbosis, Ratnoff, OD and Fcrhes (eds.) Grune 8 Stratton, Tew York 198Z. ABSTR4CTS: Bick, RL, Shanbrom, E, Bishop, R: Fibrinolytic abnormalities in m;•eloproliferatiti•e disorders. Clin. Res. 21:264, 1970 Thompson, WB: RL Bick , , Fibrinolytic abnormalties in various clinical states Am. J. Clin. Path. 156:130, 1971. Bick, RL, Bishop, RC, Warren, M, Stemmer, E: Changes in f'brinolysis and fibri.n.olytic en:ymes during extraco:p creal circuiation.~ Trans. Am. Soc. Hematol. 109, 1971. Bick, RL, and Adams, T: Fibrinolytic abnormalities in myeloproliferative disorders. Clin. Res. 21:264, 1973. Bick, RL, Schmalhorst, WR, Crawford, L, Holtermann, M, Arbegast, `R: Platelet adhesion defects during cardiopulmonary bypass. Clin. Res. 22:383, 1974 . Bick, RL, Schmalhorst, WR, Crawford, L., Holtermann, M. Arbegast, NR: Primary hyperfibrinolysis during cardiopulmonary bypass. Clin. Res. 22:383, 1974. Bick, RL, Arbegast, N, Holtermann, M, Crawford, L, and Schnalhorst, W: Platelet function abnormalities in cardiopulmonary bypass Circulation 50:301, 1974. Bick, Rl., Schmalhorst, WR, and Shanbrom, E: Abnormalities in platelet function induced by cardiopulmonary bypass. Transact VII World Congress of Cardiology Supp. 1974, Buenos Aires. -10- Cii'.:~ :CJLL'd 11TAr".: :.BS:'iACTS Ccont.): 3( Bick, RL, Schmalhorst, hR, Adams, T, .L^begas He:^orrhagic syndromes associated with cardio pa*_hcgenesis, diagnosis, and management. Trans. XII World Congress Int. Cardiovas. So• Bick, RL: Prothrombin complex concentrat'es and chronic T!-.romb. Diath. Haemorrh. 34:875, 1975. Bick, RL, Schmalhorst, {vR: Blood component therapy in disseminated intra Clin. Res. 23:269, 1975. Bick, RL, ScfLmalhorst, WR, Arbegast, N: The henorrhagic diathesis created by cardiopu Am. J. Clin. Path, 63:588, 1975 Bick, RL: Fibrinolytic enzymes in metastatic cancer xm. J. Clin. Path. 65:266, 1976 B- RL, F`;,ete, LP Wilson, WL: TrcacmO.,nt of disseminated irr-avascular coagu: Trans.Am.^Soc. Hematol. 167, 1976. _ Bick, RL, Klein, CA, Fekete, LF, Wilson, WL: Alterations of hemostasis associated with mali '"rax>. Am. Soc. Hematol. 163, 1976. Fekete, LF, Wilson, WL, Bick, RL: The large scale preparation of clottable fibri high potency factor VIII concentrate. Trans. XII Congress World Fed. of Hemophilia, Thrombosis and Hemostasis, 38:348,.1977. _ Bick, RL, Fekete, LF, Wilson, WL• Clinical use of platelet adhesion Trans. 'vI int. Congress on Thrombosis and Hemo: Philadelphia, 1977. Sick, RL, Dukes, ML, Fekete, LF, and Wilson WL: Antithrombin III as a diagnostic aid in dissemi Trans. VI. Int. Congress on Thrombosis and Hemc Philadelphia, 1977.

307 Cu:~:CU L,~ ~t 1 _r-.ic^: --=4 L :BSi'R.aCTS (cont.): Bick, RL, Sch•:alhorst, hR, Adams, T, Arbagast, N: Hemorrhagic syndromes associated with cardiopu:-:_7ary b-pass pathogenesis, diagnosis, and manage.ent. Trans. XII World Congress Int. Cardiovas. Soc. p. 7, 1975 Bick, RL: Prothrombin complex concentratbs and chronic liver disease. Thromb. Diath. Haemorrh. 34:875, 1975. Bick, RL, Schmalhorst, hR: Blood component therapy in disseminated intravascular coagulation. Clin. Res. 23:269, 1975. Bick, RL, SciL-nalhorst, WR, Arbegast, N: The hecnorihagic diathesis created by cardiopulaonary b,-,sss. Am. J. Clin. Path. 63:588, 1975 Bick, RL: Fibrinolytic enzymes in metastatic cancer Am. J. Clin. Path. 65:266, 1976 oick, RL, Fekete, LF, Wilson, WL: Treatment of disseminated intravascular waguietion with antithrombin I11. Trans. Am. Soc. Hematol. 167,1976. Bick, RL, Klein, CA, Fekete, LF, Wilson, WL: Alterations of hemostasis associated with malignant paraprotein disorders. Trans• Am. Soc. Hematol. 163, 1976. Fekete, LF, Wilson, WL, Bick, RL: The large scale preparation of clottable fibrinogen-free, high purity, . high potency factor VIII concentrate. Trans. XII Congress World Fed• of Hemophilia, New York Thrombosis and Hemostasis, 38:348, 1977 Bick, RL, Fekete, LF, Wilson, WL: Clinical use of platelet adhesion Trans. VI int. Congress on Thrombosis and Hemostasis Philadelphia, 1977. - Bick, RL, Dukes, ML, Fekete, LF, and Wilson WL: Antithrombin III as a diagnostic aid in disseminated intravascular coagulation. Trans. VI. Int. Congress on Thrombosis and Hemostasis, Philadelphia, 1977.

308 C'JRdICULu!t VIT?F: ,_?c.R L. Fil'K, '.D. x95T4ACTS (ccnt.): Dick, RL, Dukes, ML, Fekete, LF: Antithrombin III for diagnosing and nonitoring dissemir.ated intravascular coagulation. Trans. First Florence Conference on Hemostasis and 77irocbosis Florence, Italy 1977. Bick, RL, Fekete, LF, Wilson, WL: Platelet adhesion in clinical medicine. ' Trans. First Florence Conference on Hemostasis and Thrombosis Florence, Italy, 1977. Sick, RL, Arbegast, N'R, Fekete, LF, and Wilson, 1+'L: Heparin neutralization following cardiopulmonary b}pass., Clin. Res. 25:209, 1977. Dick, RL: Disseminated intravascular coagulation. ' Am. J. Clin. Path. 68:93, 1977 Sick, RL, Dukes, ML, Wilson, WL, Fekete, LF: Simple assay for plasma heparin introduced. J.A.M.A. Jan. 2, Vol. 239, No. 1, 1978. Dick, RL, and Fekete, LF: The development and evaluation of a new coagulation standard for protimes, PTT's, and all coagulation factor assays (`CCP). Blood Vol. 52, No. S, 321, 1978. . RL, and Wilson, WL: Bick , Multiple myeloma and second malignancies: a three year follow-up of forty patients. Blood 52:496, 1978. Sick, RL, Dukes, ML, Wilson, WL, Fekete, L: Antithrombin III patterns in disseminated intravascular coagulation: use for diagnostic and subsequent monitoring of anti-coagulation therapy. Am. J. Clin. Path. Vol. 69, No. 2, 203, 1978. Sick, RL, Dukes, ML, Wilson, WL, Fekete, LF: A new heparin assay for assessing heparin reversal during cardiopulmonary bypass. Am. J. Clin. Path. Vol. 69, No. 2, p. 204, February 1978. 309 C":;F?CJL;Df "%-IT"aE: :BS TR4CTS (ccnt. ) : Bick, RL, and Wilson, WL: Sfultiple myeloma and second malignancies: A thre patients. Blood, Vol. 52, No. S, 240, November, 1978 Bick, RL, and Fekete, LF:- Hereditary hemorrhagic telangiectasia and associ defects. Blood, Vo. 52, No. 5, 179, 1978. Fekete, LF, and Dick, RL: ine development and evaluation of a new coagulat .TT's and all coagulation factor assays. Elood, Vol. 52, No. 5, 181, 1978. Bick, RL: Biological antithrombin III levels. J.A.M.A., January 23, Vol. 239, No. 4, 1978 Bick, RL, Fekete, LF: Alterations of hemostasis during cardiopulmonar) membrane and bubble oxygenators. Trans. Am. Soc. Clin. Path. October, 1979, Las L Bick, RL, and Fekete, LF: Hereditary hemorrhagic telangiectasia and associ defetts. Blood, 54:745, 1979. Bick, RL, and Skondia, V: Piracetam: results of a preliminary in vivo tria Blood, 54:635, 1979. Bick, RL, Fekete, LF, Dukes, ML, Gaal, PG. Smit} Hereditary hemorrhagic telangiectasia and assoc: defects. Am. J. Clin. Path. Vol. 73, #2, p. 300, 1980. Bick, RL and Fekete, LF: Alterations of hemostasis during cardiopulmonar; between membrane and bubble oxygenators. Am. J. llin. Path. Vol. 73, #2, p. 300, Februar, -12- -13-

309 CiRR1CJLU?I VIT.>E: -._. :=3 L. B'CK, M.D. ABSTRACTS (ccnt.): Bick, RL, and Wilson, WL: 4ultiple myeloma and second malignancies: A three year follow-up of forty patients. Blood, Vol. 52, No. 5, 240, November, 1978 Bick, RL, and Fekete, LF:• Hereditary hemorrhagic telangiectasia and associated thr:.xbahemorrhagic defects. Blood, Vo. 52, No. S, 179, 1978. '- Fekete, LF, and Bick, RL: The developwent and evaluation of a new coagulation standard for protiWes, PTT's and all coagulation factor assays. Blood, Vol. 52, No. 5, 181, 1978. Bick, RL: Biological antithrombin III levels. J.A.M.A., January 23, Vol. 239, No. 4, 1978 Bick, RL, Fekete, LF: Alterations of hemostasis during cardiopulmonary bypass: A comparison between membrane and bubble oxygenators. Trans. Am. Soc. Clin. Path. October, 1979, Las Vegas, Nevada. Bick, RL, and Fekete, LF: Hereditary hemorrhagic telangiectasia and associated thrombohemorrhagic defetts. Blood, 54:745, 1979. Bick, RL, and Skondia, V: Piracetam: results of a preliminary in vivo trial as a platelet suppressant. Blood, 54:635, 1979. Bick, RL, Fekete, LF, Dukes, ML, Gaal, PG, Smith, R: Hereditary hemorrhagic telangiectasia and associated thrombohemorrhagic defects. Am. J. Clin. Path. Vol. 73, #2, p. 300, 1980. Bick, RL and Fekete, LF: Alterations of hemostasis during cardiopulmonary bypass (CPB): A comparison between membrane and bubble oxygenators. Am. J. Clin. Path. Vol. 73, 02, p. 300, February, 1980. -13-

310 C_2RiC:^'u'm VITAE: --=R L. 'A.D. A9STR4CTS (cont.): Fareed, J., Messmore, HL, and Bick, RL: Quality Control and Standardi:ation of \ewer Methods in Henostatic Testing Presented - International Society of Pathology, 1980. Bick, RL: Disseminated intravascular coagulation and related s;'ndi'o-es: etiology, pathophysiology, d~agnosis and management. In The Year Book of Cancer, 1980 (R.L. Clark et al Eds.) Year Book Medical Publishers, Inc. , Chicago, ILL 1980, p303. Bick, RL, Stedman, RL, Kronick, PL, and Hillman, E: Studies related to tobacco glycoprotein: a claimed activator bf coagula*ion, fibrinolysis, complement, kinin, and a claimed allergen. Clinical Research, Vol. 29, No. 2, 178A, 1981. Bick, RL, Skondia, V, and Fritch, D: Hypercoagulability in diabetes ar.d its correction by an antiplatelet d ug: Piracetam. Clinical Research, Vol. 29, No. 2, 400 A, 1981. Bick, ?.L: Hereditary hemorrhagic telangiectasia and disseminated intravascular coagulation: a new clinical syndrome Thromb. Haemostas. 46:9, 1981. Bick, RL, Fareed, J, and Skondia, V: Pirl',etam: a new platelet suppressing drug. Thromb. Haemostas. 46:67, 1981. V: and Skondia MK Nix RL , , , , Bick, The effect of piracetam in preventing recurrent deep venous thrombosis. Thrombos. Haemostas. 46:91, 1981. Bick, RL, Arbegast, NR: A comparison of chromogenic, fluorogenic, and fibrinogen substrate assays for determination of plasma heparin. Thrombos. Haemostas. 46:214, 1981. Bick, RL, Stedman, RL, Kronick, PL, Hillman, E, and Fareed, J: Studies related to tobacco glycoprotein: a claimed activator of coagulation, fibrinolysis, complement, kinin, and a claimed allergen. Thrombos. Haemostas. 46:231, 1981. 3: CURRICULUM VITAE: ABSTR4CTS: (cont.) Bick, RL, and McClain, BJ: A clinical comparison of chromogenic, fluo- substrate assays.for determination of anti- Thrombos. Haemostas. 46:364, 1981. Bick, RL, and Faulstick, D- Antithrombins and coronary artery disease. Thrombos. Haemostas. 46:372, 1981 Bick, RL, Arbegast, NR, and Schmalhorst, Wf Alterations of hemostasis during cardiopulrr membrane and bubble oxygenators. Thrombos. Haemostas. 46:392, 1981. Bick, RL: " Disseminated intravascular coagulation: a c 48 patients. Thrombos. Haemostas. 46:395, 1981. Bick, RL, Skondia, V, and Fritch, D: Hypercoagulability in diabetes and its corr Piracetam. _ Thrombos. Haemostas. 46:439, 1981. Bick, RL and McClain, BJ: A clinical comparison of chromogenic, fluor substrate assays for determination of antit Am. J. Clin. Path. 77:238, 1982. Bick, RL: Disseminated intravascular coagulation: a c patients. Am. J. Clin. Path. 77:244, 1982. - LETTERS PUBLISHED: Bick, RL Anhalt, J: Needle malaria N. Eng. J. Med. p. 856, April 1971. Bick, RL, Anhalt, J: Malaria in drug addicts J.A.M.A. 216:1036, 1971 Bick, RL: Prothrombin complex concentrates and chroni Thrombos. Res. 7:825, 1975. Bick, RL: Antithrombin III and factor VIII in patient Am. J. Clin. Path. Vol. 69, No. 2, 1978. 14 qX' -15

311 CURRICULUM VITAE: ROUGER L. BIC.I', M.D. ABSTRACTS: (cont.) Bick, RL, and McClain, BJ: A clinica( comparison of chronogenic, fluorometric, and natural (fibrinogen) substrate assays•for determination of antithrombin-III. Thrombos. Haemostas. 46:364, 1981. Bick, RL, and Faulstick, D: Antithrombins and coronary artery disease. Thrombos. Haemostas. 46:372, 1981 8ick, RL, Arbegast, NR, and Schmalhorst, WR: Alterations of hemostasis during cardiopulmonary bypass (CPB): a cor..parison between membrane and bubble oxygenators. Thrombos. Haemostas. 46:392, 1981. Bick, RL: Disseminated intravascular coagulation: a clinical/laboratory correlation in 48 patients. Thrombos. Haemostas. 46:395, 1981. Bick, RL, Skondia, V, and Fritch, D: Hypercoagulability in diabetes and its correction by an antiplatelet drug: Piracetam. Thrombos. Haemostas. 46:439, 1981. Bick, RL and McClain, BJ: A clinical comparison of chromogenic, fluorometric, and natural (fibrinogen) substrate assays for determination of antithrombin III. Am. J. Clin. Path. 77:238, 1982. Bick, RL: Disseminated intravascular coagulation: a clinical laboratory correlation in 48 patients. Am. J. Clin. Path. 77:244, 1982. LETTERS PUBLISHED: Bick, RL Anhalt, J: Needle malaria N. Eng. J. Med. p. 856, April 1971. Bick, RL, Anhalt, J: Malaria in drug addicts J.A.M.A. 216:1036, 1971 Bick, RL: Prothrombin complex concentrates and chronic liver disease. Thrombos. Res. 7:825, 1975. Bick, RL: Antithrombin III and factor VIII in patients with neoplasms. Am. J. Clin. Path. Vol. 69, No. 2, 1978. -15-

312 q:RkIC,_:LiiM VIT.:E: 3 CLRRICUL'J.1f VITAE: SCIE\TIFIC PRESE\TATIS3/I\'IITED SPEAK i SCIE.N;T1IFIC PRESEN TATIONS/I\l'ITED SPEai:ERiiN'04tSHJP DIRECTOR: The effects of pinealectomy and environmental lighting on the gonadal, thyroid, and total body weight of female Long-Evans Rats. Presented to Am. Assoc. Anatomist, New Orleans, 1968. Simplified measurements of fibrinolytic potential in myocardial infarction. Presented to Am. Med. Association Multidiscipline Forum. Fibrinolytic activity in various clinical states. Presented to Am. Soc. Clin. Path., Las Vegas, Sev. 1971. Australia Antigen: A comparison bf three detection aethods in a population of high risk for hepatitis. Hyperfibrinolysis in cirrhosis. Presented to Am. Coll. Physicians, Regional Meeting, Los Angeles, CA., 1972. The special problem of disseminated intravascular coagulation in malignancy Presented to Am. Cancer Society, Regional Meeting, 1972. Mechanisms of anemia in malignancy. Presented to American Cancer Society, Regional meeting, 1972. Prothrombin complex concentrate: use to control the hemorrhagic diathesis of chronic liver disease. Presented to Am. College of PhysiFians, Regional Meeting, Palm Springs, CA., 1973. Heparin therapy for disseminated intravascular coagulation Preeented-to UCLA 3rd Annual Anesthesia Postgraduate Seminar, UCLA, 1973. A systemic approach to the diagnosis of bleeding disorders. Presented for UCLA Postgraduate Seminar in Internal Medicine: Current Trends in Internal Medicine, January, 1974. A systemic approach to the diagnosis of anemias. Presented to UCLA Int. Medicine Seminar. Current Trends in Internal Medicine, January, 1974. Current therapy for leukemias and lymphomas Presented for UCLA Internal Medicine Postgraduate Seminar; Current Trends in Internal Medicine, January, 1974 -16- Therapy for metastatic solid t::..ors. Presented for UCLA Postgraduate Intern Current Trends in Internal Medicine, J Malignant th;r.,oma: A review of 20 cas Presented to American College of Physi Hemostatic Defects Induced by Cardiopu Presented to International College of : Hemostatic defects induced-by cardiopa: Presented to the American Association c Washington, D.C., 1974. Control of bleeding associated with cai National Meeting of the Southern Thorac Special Symposium Participant: "Side E: World Federation for Hemophilia, Helsir Hemorrhagic Syndromes Associated with C Pathcgenesis, Diagnosis, and Management Society (;•early meeting), Edinhurgh, Sc Bleeding Associated with Cardiopulmona: UCLA, 1975. • - Bleeding Problems in the O.R. Special Surgery, Kern County General Hospital, A Systematic Approach to the Diagnosis Santa Monica Hospital II Annual Family Course, UCLA, 1975. Program and Workshop Director: Recent of Hemostasis, American Society of Cli Platelet Adhesion, Bleeding Times, and Presented to the American Society of CI 1975. Prothrombin Complex Concentrates and Di Presented to the World Federation of He Recent Concepts and Evaluation of Disor American Society of Clinical Pathology

313 CURRICULUM VITAE: :=5_R L. ?._CK , '1.D. SCIE!tTIFIC PRESE\ZATISNS/I\TITED SPEA}-n,'NC:.}:::='JP DIREI"TCR: Therapy for metastatic solid tWmors. Presented for UCLA Postgraduate Internal Medicine Seminar: Current Trends in Internal Medicine, January, 1974. Malignant th;r•,oma: A review of 20 cases. Presented to American College of Physicians, New York, 1974. Hemostatic Defects Induced by Cardiopulmonary Bypass. Presented to International College of Angiology, Montreal, 1974. Hemostatic defects induced by cardiopmlmonary bypass. Presented to the American Association of Clinical Pathologists, Washington, D.C., 1974. Control of bleeding associated with cardiopui,.anary bypass: Panel member. National Meeting of the Southern Thoracic Society, Williamsburg, Virginia, 1974. Special Symposium Participant: "Side Effects of antihemophilia Concentrates". World Federation for Hemophilia, Helsinki, Finland, 1975. Hemorrhagic Syndromes Associated with Cardiopulmonary Bypass: Pathogenesis, Diagnosis, and Management. International Cardiovascular Society (;'aarly meeting), Edinburgh, Scotland, 1975. Bleeding Associated with Cardiopulmonary Bypass. Cardiology Grand Rounds, UCLA, 1975. Bleeding Problems in the O.R. Special UCLA Lecture series; Department of Surgery, Kern County General Hospital, Bakersfield, California, 1975 A Systematic Approach to the Diagnosis of Bleeding Disorders. UCLA, Santa Monica Hospital II Annual Family Practice Refresher Postgraduate Course, UCLA, 1975. Program and Workshop Director: Recent Concepts and Evaluation of Disorders of Hemostasis, American Society of Clinical Pathologists, 1975. Platelet Adhesion, Bleeding Times, and Aspirin Presented to the American Society of Clinical Pathologists, Chicago; 111. 1975. Prothrombin Complex Concentrates and Disseminated Intravascular Coagulation. Presented to the World Federation of Hemophilia, Helsinki, Finland, 1975. Recent Concepts and Evaluation of Disorders of Hemostasis and Thrombosis. American Society of Clinical Pathology National Workshop, September, 1975. -17- BJII

314 CUiR?CL•'__"•f VIT.aE: SCIESCIFIC PRESEN-fATTG':S/PvVITED S?EAiTR;iiCdKSHCP DIKECT^_R (cont.) Fibrinolytic Enzymes in Metastatic Cancer. Presented to the American Society of Clinical Pathologists, Naticaal Meeting, Chicago, Ill., September, 1975. Recent Advances in Laboratory Aspects of Internal '.Iedicine: von 1•:il'_ebrand's Disease, Disseminated Intravascular Coagulation and Primary H~2erfibrino(geno)- lytic Syndromes. Palm Springs, CA., Dctober, 1975. Hemorrhagic Syndromes Associated with Cardiopulmonary Bypass. An approach to Differential Diagnosis and Management. Presented to the American Thoracic Society, 1975. Director: Modern Concepts and Evaluation of Thrombosis and Hemostasis lation Seminar C . oagu American Society of Clinical Pathologists, National Meeting, Dallas, Texas, 1976. - Director: Special Diagnostic Problems in Hemostasis and Thrombosis: Advanced Coagulation Seminar. American Society of Clinical Pathologists, National Meeting, Dallas, Texas, 1976. Modern Concepts and Evaluation of Hemostasis and Thrombosis: Two Day Seminar, UC at Santa Barbara, California, 1976. Director: Recent Concepts and Evaluation of Hemostasis and Thrombosis: American Society of Clinical Pathologists, Regional Center, Long Beach, Cal$brnia, 1976. Director: Recent Concepts and Evaluation of Hemostasis and Thrombosis. American Society of Clinical Pathologists, National Meeting, Los Angeles, .California, 1976. Director: Difficult Diagnostic Problems in Hemostasis and Thrombosis (Advanced Seminar) American Society of Clinical Pathologists, National Meeting, Los Angeles, California, 1976. Director: Recent Concepts and Evaluation of Hemostasis and Thrombosis, American Society of Clinical Pathologists, Regional Center, Chicago, Illinois, November, 1976. - 315 CU:RIC-UL;;'1 VITAE: =c:^er t. SC:-NTIFIC PRESENTA.T:Q:<S 8 I\l'ITED S7E=lE<, Current Concepts of Hemostasis; Clinical a, of ThromSohemorrhagic Phenomena; Director lanericdn Society of Clinical Pathologists, ~ Personnel Regional Education Program, Los P.- MoJern Concepts and Evaluation of Hemostasi, American Society of Clinical Pathologists, f 1977 Disseminated Intravascuiar Coagulation and ' American Society of Clinical Pathologists, F Nevada, 1971 Difficult Diagnostic ProbTems in Hemostasis American Society of Clinical Pathologists, F Nevada, 1977 Recent Concepts and Developments in Evaluati and Thrombosis • X1A/C'4A, Palm Springs, 1978 Second Annual Southern California Blood Clot American Society of Clinical Pathologists, S t:odern Concepts and Evaluation of 4a qstasis P.,,erican Society of Clinical Pathologists, k Disseminated Intravascular' Coagulation and R American Society of Clinical Pathologists, F1 Difficult Diagnostic Problems in Hemostasis American Society of Clinical Pathologists, N. Current Concepts of liemostasis and Thrombosi American Association of Clinical Chemistry, Modern Concepts and Evaluation of Hemostasis American Society of Clinical Pathologists, F Disseminated Intravascular Coaoulation and R American Society of Clinical Pathologists, F Difficult Diagnostic Problems in Hemostasis American Society of Clinical Pathologists. F Current Concepts of Hemostasis: Clinical and Thrombohemorrhagic Phenomena American Society of Clinical Pathologist, Re Program, August, Charleston, South Carolina, ~ W ~ Q ~ ~ ~ 95-077 0-82-21 ~

315 CL"~IC L°:1 Y:TAE: Pc-'.er L. .lck, M.D. SCIES?IFiC PKESENT.AT:ONS F, I.\lITEO SFF`K-E3': ^13EC^R (=t.) Current Concepts of Hamostasis; Clinical and La~oratory E:aications of ThromSohemorrhagic Phenomena; Director Arrsric3n Society of Clinical Pathologists, Corrission on tiedical Laboratory Personnel Regional Education Program, Los Angeles, 1977 Modern Concepts and Evaluation of Hemustasis and Thror•bosis; Director American Society of Clinical Pathologists, Fall ~'eeting, Las l'egas, Nevada 1977 Disseminated Intravascular Coagulation and Related Syndromes; Director American Society of Clinical Pathologists, Fall Meeting, Las Vecas, Nevada, 1977 Difficult Diagnostic Problems in Hemostasis and Thrombosis; Director American Society of Clinical Pathologists, Fall Meeting, Las Vegas, Nevada, 1977 Recent Concepts and Developments in Evaluating Disorders of He^ostasis and Thrombosis - AMA/CMA, Palm Springs, 1978 Second Annual Southern California Blood Clotting Symposium American Society of Clinical Pathologists, Santa Monica, 1978 :'odern Concepts and Evaluation of Hecostasis and Thrr„bcsis; Director " American Society of Clinical Pathologists, March, Dallas, 1978 Disseminated Intravascular' Coagulation and Related Syndromes; Director American Society of Clinical Pathologists, Flarch, Dallas, 1978 Difficult Diagnostic Problems in Hemostasis and Thrombosis; Director American Society of Clinical Pathologists, March, Dallas, 1978 Current Concepts of Hemostasis and Thrombosis, Workshop Director American Association of Clinical Chemistry, San Francisco, 1978 Modern Concepts and Evaluation of Hemostasis and Thrombosis; Director American Society of Clinical Pathologists, Fall Meeting, St. Louis, 1978 Disseminated Intravascular Coagulation and Related Syndromes; Director American Society of Clinical Pathologists, Fall MeetinV, St. Louis, 1973 Difficult Diagnostic Problems in Hemostasis and Thrombosis; Director American Society of Clinical Patholoaists, Fall Meeting, St. Louis, 1978 Current Concepts of Hemostasis: Clinical and Laboratory Evaluation F ]hrombohemorrhagic Phenomena American Society of Clinical Pathologist, Regional Cont. Medical Education Program, August, Charleston, South Carolina, 1978 -19- 0 95-077 0-82-21 i 0 0

316 CuRRICULT-I VIT:E: R'' er L. °_ick, '+..D; SCIE\71FIC FRESE\T>TICNS 6 IUVITED C REC:DR (c^.~ Recent Concepts and Deyelopments in E:alcatir.g Discrders of °e:cstasis and Thrombosis American Society of Clinical Pathologists, Chica3o, 1978 Modern Concepts and Evaluations of HeWostasis and Thrombosis; Director American Society of Clinical Pathologists, San Diego, 1978 Disseminated Intravascular Coagulation and Related Syndro-es; Director American Society of Clinical Pathologists, San Diego, 1978 Difficult Diagnostic Problems in Hemostasis and Thrombosis; Director American Society of Clinical Pathologists, San Diego, 1978 Basic Mechanisms of Hemostasis Grand Rounds (All Staff), Northridge Hospital, Korthridge, CA, 1978 Current Status of Mini-heparin Grand Rounds (All Staff), Northridge Hospital, Northridge, CA, 1978 Hypercoagulability and Thrombosis Grand Rounds (All Staff), Northridge Hospital, Northridge, CA, 1978 Modern Concepts of Hemostasis and Thrombosis; Director American Society of Clinical Pathologist (Naticnal Secinar), St. Louis, Missouri, 1978 Difficult Diagnostic Problems in Hemostasis and Thrombosis; Director American Society of Clinical pathologist, (National Seminar), St. Louis, Missouri, 1978 jlntithrombin III: Theory and Clinical Applications Annual Hemostasis Workshop; John Penner - Director; Ann Arbor, Michigan, 1978 Disseminated Intravascular Coagulation and Related Syndromes; Director American Society of Clinical Pathologist, St. Louis, Missouri, 1978 (National Seminar) Course in Hemostasis to Laboratory Technology Students California State College at Bakersfield, Bakersfield, CA., 1978 Disseminated Intravascular Coagulation and Related Syndromes Canadian Society of Pathologists, Ontario, Canada, 1978 Current Concepts of Hemostasis and Thrombosis American Society of Clinical Pathologists (Continuing Education Comaittee- Seminar) Chicago, Illinois, 1978 317 rjc:iCJL:1.M 61TAE: SCIENTIFIC PRESENTATICNS B I>T1TED Disseminated Intravascular Coagulation and California Society of Pathologists, San Fr Current Status of Henostasis, 7Tror,.b.sis a A.-erican Heart Association Annual Meeting, Difficult Diagnostic Problems in Hesostasi :,:.erican Society of Clinical Pathologist ( Current Concepts of Hemostasis and Throcbo ;rerican Society of Clinical Pathologist,( Modern Concepts and Evaluation of Hemostas knerican Society of Clinical Pathologist, DisseRSnated Intravascular Coagulation and L-erican Society of Clinical Pathologist, Modern Laboratory Evaluation of Heapstasis A:-,erican Society of Clinical Pathologist, Current Concepts in Hemostasis and Thrombo California Society of Pathologists, Annual Cisseminated Intravascular Coagulation and A-erican Society of Clinical Pathologist ( Lincoln, Nebraska, 1979 Hypercoagulability Colorado Association for Continuing Medica Current Concepts of Hemostasis and Thrombo A:,erican Society of Clinical Pathologist ( '.ebraska, 1979 11odern Concepts and Evaluation of Hemostas S:.erican Society of-Clinical Pathologists, Difficult Diagnostic Problems in Hemostasi k-erican Society of Clinical Pathologists, -21-

317 C'JSn1CU::uN V1T4E: L. Sice, V.D. SCIENTIFIC FRESEN-ATIC]S 6 IN~I?EJ Disseminated Intravascular Coagulation and Re:ated S}^4=a.es (Se-.`.nar) California Society of Pathologists, San Francisco, CA., 1978 Current Status of Henostasis, Thror..basis and Antiplatelet Agents A..,erican Heart Association Annual Meeting, Sacra_-.ento, CA., 1979 Difficult Diagnostic Problems in He-..cstasis and Thror.bosis; D'.rector A,:.erican Society of Clinical Pathologist (National Se:.inar), \er Drleans, 1979 Current Concepts of Hemosiasis and Thror~bosis; Director ;r..erican Society of Clinical Pathologist,(National Ser_inar), Ne. Orleans, 1979 Modern Concepts and Evaluation of Hemostasis and Th:o:.bosis; Director American Society of Clinical Pathologist, (National Se-inar), Ne+. Orleans, 1979 Disseminated Intravascular Coagulation and Related Syndroa.es; Director Aa,erican Society of Clinical Pathologist, (National Secinar), New Orleans, 1979 Modern Laboratory Evaluation of Heapstasis and Thrombosis; Director Anerican Society of Clinical Pathologist, (National Seminar), New Orleans, 1979 Current Concepts in Hemostasis and Thro-bosis, Director California Society of Pathologists, Annual Meeting, San Francisco, CA., 1979 Disseminated Intravascular Coagulation and Related Syndromes A:.eri.can Society of Clinical Pathologist (Regional Educational Se^inar) Lincoln, Nebraska, 1979 Hypercoagulability • Colorado Association for Continuing Medical Laboratory Education, Colorado, 1979 Current Concepts of Hemostasis and Thrombosis; Director American Society of Clinical Pathologist (Regional Education Program), Lincoln, Nebraska, 1979 Modern Concepts and Evaluation of Hemostasis and Thror3osis; D'.rector American Society of-Clinical Pathologists, Fall Meeting, Las Vegas, Oct., 1979 Difficult Diagnostic Problems in Hemostasis and Thror..bosis; Director American Society of Clinical Pathologists, Fall Meeting, Las Vegas, Oct., 1979 -21-

318 CCRRICULG!t S'I`:AE: I 3_Jier L. 9ici., M.D. SCIE\TIFIC :RESE:'7aTTO.':S 8 I!C:ITED D:;,ECi.^R cc,nt.) Dissecinated intravascular Coagulation and Re!ated Syndro,^es; Dire:.tor American Society of Clinical Pathologists, Fall Sleeting, Las Vegas, Oct., 19-9. Modern Laboratory Evaluation of Hemostasis and P:rocbosis; Director i American Society of Clinical Pathologists, Fall Meeting, Las Vegas, Oct., 19'9. Review Course in Coagulation American Society of Clinical Pathologists, Winter Meeting, San Diego, CA - January, 1980 Difficult Diagnostic Problems in He*:ostasis and Thrombosis, Winter Meeting American Society of Clinical Pathologists, San Diego, California, January, 1980 Disseminated Intrsvascular Coagulation American Society of Clinical Pathologists, Winter Meeting, San Diego, CA January, 1980 Modern Concepts and Evaluation of Hemostasis and Tnroc.Sosis, Spring ?:eeting American Society of Clinical pathologists, Atlanta, Georgia, March, 1980 Difficult Diagnostic Problems in Hemostasis and Thrombosis, Spring Meeting American Society of Clinical Pathologists, Atlanta, Georgia, March, 1980 Disseminated Intravascular Coagulation and Related S}ndromes, Spring Meeting American Society of Clinical Pathologists, Atlanta, Georgia, March, 1980 Clinical Applications of Plasma, Heparin Levels, Antithrombin-III, Plasminogen, and Alpha-2-antiplasmin, San •Leandro Doctors Hospital, April 1, 1980 Disseminated Intravascular Coagulation (Grand Rounds Presentation) Stritch School of Medicine, Loyola University, Maywood, Illinois, May, 1980 Monitoring Heparin Therapy (Surgical Grand Rounds) Stritch School of Medicine, Loyola University, Maywood, Illinois, May, 1980 ~. Hereditary Hemorrhagic Telangiectasia and Associated Thrombohemorrhagic Defects Wayne State University, School of .`ledicine, Detroit, Michigan, May 1980 Disseminated Intravascular Coagulation: A Clinical/Laboratory Correlation in 48 Patients Wayne State University, School of Medicine, Detroit, Basic Mechanisms of Hemostasis and Thrombosis Michigan, May 1980 Traveling Consultant in Hematology/Medical Oncology, Tripler Army Medical Center, Honolulu, Hawaii, Jur,e, 1980 Hereditary and Acquired Vasci..lar Defects and Hereditary and Acquired Platelet Function Defects Traveling Consultant in Hemoe.tasis/Medical Oncology, Tripler Army Medical Center, Honolulu, Hawaii, June, 1980 Ik 319 CCRR?CU:.UD1 %'I"AE: SCIENTIFIC PRESE\TATIONS/I:VITED SPEAK-ER/nCF Congenital Coagulation Defects and von Wille Traveling Consultant in Hematology/Medical C Honolulu, Hawaii, June, 1980. Disseminated Intravascular Coagulation and F Traveling Consultant in Hematology/Medical Center, Honolulu, Hawaii, June, 1980. H,vpercoagulability, Anticoagulant Therapy, Traveling Consultant in Hematology/Medical c Honolulu, Hawaii, June, 1980. Current Concepts of Heparin Therapy (Surgic +!erc.• Hospital, Miami, Florida, September . Disse-inated ;ntravascular Coagulation (Med' Mercy Hospital, Miami, Florida, September : Hemostasis and Bleeding Disorders in Probler Mt. Sinai Medical Center, Miami Beach, FL . Clinical pplications of !tcasuring Antithro: :ts Relationship to Monitoring Heparin Ther Kt. Sinai Mediaal Center, Miami Beach, F1 . Current Concepts of Heparin Therapy Valley Medical Center, Fresno, CA Septembe . Disseminated Intravascular Coagulation L'alley Medical Center, Fresno, CA Septemb Disseminated Intravascular Coagulation and American Society of Clinical Pathologists, St. Louis, October, 1980. Difficult Diagnostic Problems in Hemostasis 4merican Society of Clinical Pathologists, St. Louis October 1980. Modern Concepts and Evaluation of Hemostasi american Society of Clinical Pathologists, St. Louis October 1980. Monitoring Heparin Therapy 8 Mini-Heparin " Dameron Hospital Association, Stockton, CA . -23-

319 q1 CO:RICULJM VI?.E: -1CDGER L. BICK, ';.D. SCIENTIFIC PRESE\TnTIOSS/I VITED SPEAKER/KCRi:S;OP DIRECTOR (cont.): Congenital Coagulation Defects and von Willebrand's S)^:3rome Traveling Consultant in Hematology/Medical Oncology, Tripler Arry Medical Center, Honolulu, Hawaii, June, 1980. Disseminated Intravascular Coagulation and Related Syndromes. Traveling Consultant in Hematology/Medical Oncology, Tripler Arsy Medical Center, Honolulu, Hawaii, June, 1980. Hypercoagulability, Anticoagulant Therapy, and Thrombolytic Therapy Traveling Consultant in Hematology/Medical Oncology, Tripler ,1rmy Medical Center, Honolulu, Hawaii, June, 1980. Current Concepts of Heparin Therapy (Surgical Grand Rounds) Mercy Hospital, Miami, Florida, September 1980. Disseminated Intravascular Coagulation (Medical Grand Rounds) Mercy Hospital, Miami, Florida, September 1980. Hemostasis and Bleeding Disorders in Problem Patients (Grand Rounds) Mt. Sinai Medical Center, Miami Beach, FL September 1980. Clinical :pplications of `4cassring Antithrombin III Levels; With f.mphasis.on its Relationship to Monitoring Heparin Therapy. (Florida Soc. Pathologists) Mt. Sinai Medioal Center, Miami Beach, F1 September 1980. Current Concepts of Heparin Therapy Valley Medical Center, Fresno, CA September 1980. Disseminated Intravascular Coagulation Valley Medical Center, Fresno, CA September 1980. Disseminated Intravascular Coagulation and Related Syndromes American Society of Clinical Pathologists, Fall Meeting St. Louis, October, 1980. Difficult Diagnostic Problems in Hemostasis and Thrombosis American Society of Clinical Pathologists, Fall Meeting St. Louis October 1980. Modern Concepts and Evaluation of Hemostasis and Thrombosis American Society of Clinical Pathologists, Fall Meeting St. Louis October 1980. Monitoring Heparin Therapy 8 Mini-Heparin Therapy (Grand Rounds) Dameron Hospital Association, Stockton, CA February 1981. . -23- II

320 CCRRICULL~4 VITAE: 3~~SER L. 3ICK, M.D. SCIE\TIFIC PRESENT.4TIONS/INAITED SPEAKER/HORKSHOP DIRECTOR (cont.): -:'L ' Syndromes of DIC American Dade Rocky Mountain Hemostasis Conference Denver, Colorado March 1981. Current Controversies About Heparin Therapy American Dade Rocky Mountain Hemostasis Conference Denver, Colorado March 1981. Modern Concepts and Evaluation of Hemostasis and Thrombosis American Society of Clinical Pathologists, Spring Meeting San Diego, CA March 1981. Difficult Diagnostic Problems in Hemostasis and Thrombosis American Society of Clinical Pathologists, Spring Meeting San Diego, CA March 1981. The Need for Tests of Hypercoagulability American Dade Hypercoagulability Seminar Miami, FL March 1981. Disseminated Intravascular Coagulation and Relatcd Syndromes Washington State Society for Medical Technology, Spring Seminar Spokane, Washington April 1981. • Antithrombin-III • California Blood Bank System Annual Meeting Los'Angeles, CA April 1981. Antiplatelet and Mini-Heparin Therapy Methodist Hospital of Southern California Arcadia, CA May 1981. Hemostasis Coagulation, DIC and Proteolysis American Society of Clinical Pathologists, Regional Educational Program Los Angeles, CA June 1981. Acquired AT-III Deficiencies that Occur with Surgery; Surgical Grand Rounds The Medical College of Wisconsin, Milwaukee, Wisconsin, June 1981. AT-III and DIC: Hematology Conference Rounds _ 3 The Medical College of Wisconsin, Milwaukee, Wisconsin, June 1981. 1z Antithrombin-III/Heparin Interrelationships and Methods of Testing for AT-III Pathology Monthly Concerence, Milwaukee, Wisconsin, June! 1981. :~ -24- 321 .=:CULUz1 VITAE: ::?iFIC 2RcSE\;ATIO.'S/I\VITED SPEAKER/ItiORKSii': editary Hemorrhagic Telangiectasia and Disser .r: Clinical Sy'ndrome. :.'th ;nternational Congress on Thrombosis and cto, Ontario, Canada July 1981. cetam: A New Platelet Suppressing Drug. h International Congress on Thrombosis and :z)nto, Ontario, Canada July 1981. Effect of Piracetam in Preventing Recurrent ':Ith International Congress on Thrombosis and -;nto, Ontario, Canada, July 1981. -parison of Chromogenic, Fluorogenic, and Fi ,vs for the Determination of Plasma Heparin ;t Internatim;al Congress on Thrombosis and .,rto, Ontario,'Canada, July 1981. es Related to Tobacco Glycoprotein: A Claim nolysis, Complement, Kinin, and a Claimed A .::th ;nternational Congress on Thrombosis and -oato, Ontario, Canada, July 1981. ..-.icians and New Methods in Coa.gulation Testin :..:al Meeting of the American Association of Cl ... Louis, Missouri July 1981. +'. iew of Hemostasis and Thrombosis c Colorado Association for Continuing Medical ..:'.on, Colorado July 1981. :.,ostasis, Coagulation, Disseminated Intravascu s=erican Society of Clinical Pathologists .anta, Georgia September 1981 --ostasis, Coagulation, Disseminated Intravascu -rican Society of Clinical Pathologists -•..er Springs, 'Maryland, September 1981 •.-.:_al Applications of AT-III •r'aban Hospital, Silver Springs, Maryland Gra >^?•eober 1981 ='C and Bleeding Problems Associated with Open H ",-ona1 Naval Medical Center Grand Rounds .':esda, Maryland September 1981 -25-

321 CL'2RICULL?t VITAE: RC:`°_R L. BICK, :d.D. SCIENTIFIC PRESE\TATIONS/I\VITED SPEAKER/WORKS&CP DIRECTOR (cant.) A Hereditary Hemorrhagic Telangiectasia and Disseminated Intravascular Coag•,a ation: A New Clinical Syndrome. VIIIth International Congress on Thronbosis and Haecostasis Toronto, Ontario, Canada July 1981. Piracetam: A\ew Platelet Suppressing Drug. VIIIth International Congress on Thrombosis and Haemostasis Toronto, Ontario, Canada July 1981. The Effect of Piracetam in Preventing Recurrent Deep Venous Throe,bosis. VIIItK International Congress on Thrombosis and Haemostasis Toronto, Ontario, Canada, July 1981. A Comparison.of Chromogenic, Fluorogenic, and Fibrinogen Substrate Assays for the Determination of Plasma Heparin VIIIth International Congress on Thrombosis and Haemostasis Toronto, Dntario,' Canada, July 1981. Studies Related to Tobacco Glycoprotein: A Claimed Activator of Coagulation, Fibrinolysis, Complement, Kinin, and a Claimed Allergen. VIIIth international Congress on Thrombosis and Haemostasis Toronto, Qntario, Canada, July 1981. Clinicians and New Methods in Coagulation Testing Annual Meeting of the American Association of Clinical Chemists (Invited Speaker), St. Louis, Missouri July 1981. A Review of'Hemostasis and Thrombosis The Colorado Association for Continuing Medical Laboratory Education Dillon, Colorado July 1981. Hemostasis, Coagulation, Disseminated Intravascular Coagulation and Proteolysis American Society of Clinical Pathologists Atlanta, Georgia September 1981 Hemostasis, Coagulation, Disseminated Intravascular Coagulation and Proteolysis American Society of Clinical Pathologists Silver Springs, Maryland, September 1981 Clinical Applications of AT-III Surbaban Hospital, Silver Springs, Maryland Grand Rounds September 1981 DIC and Bleeding Problems Associated with Open Heart Surgery National Naval Medical Center Grand Rounds Bethesda, Maryland September 1981 -25- 8 0 I

322 C~RRICCLGN VITAE: :'OI'ER L. SICK, 'f,D. SCIENTIFIC PRESE\7ATIONS/IN1'ITED SrEAKER;tiGRkS i0P DIRECTOR (cont.): Modern Concepts and Evaluations of Hemostasis and Thronbosis American Society of Clinical Pathologists and College of American Pathologists Fall Meeting, Las Vegas, Nevada, October, 1981 Difficult Diagnostic Problems in Hemostasis and ThreWbosis American Society of Clinical Pathologists and College of American Pathologists Fall Meeting, Las Vegas, Nevada, Dctober, 1981 New Methods in Coagulation Testing - Scientific Exhibit American Society of Clinical Pathologists and College of American Pathologists Fail ;•leeting, Las Vegas, Nevada, October 1981 Review Course in Coagulation American Society of Clinical Pathologists, CAY'b1-CCE Joint ASCP Project Los Angeles, CA November, 1981 ZSa C:;'.RICUL'uy VITAE: ME`7SERSHIPS: 3 International Society of Haeootology International Society on Thrombosis a Thrombosis Council-American Heart Ass American College of Angiology (Fello International College of Angiology (: American Association for the StudY of American Association for Clinical Rese Central Oncology Group (Clinical Inves American Society of Mammologists Nigerian Haematology Society Southwest Oncology Group (Clinical Inv California College Honor Society American Cancer Society International Association for the Stud) Federation of American Societists American Geriatrics Society (Founding Professional Education Committee, Ameri Research and Grant Peer Review Committe• Consultant: American Tobacco Research ( Chairman: Professional Education Commit Kern County Unit Member: Professional Education Committe County Unit

323 C'.J.'.RICUL'uM CI?kE: ?.^GER L. BICK, SI.D, MEMBERSHIPS: International Society of Haemotology International Society on Thrombosis and Haerostasis Thrombosis Council-American Heart Association American College of Angiology (Fellow) International College of Angiology (Fellow) American Association for the StudY of Neoplastic Disease. American Association for Clinical Research Central Oncology Group (Clinical Investigator) i974-1975 American Society of Mammologists Nigerian Haematology Society Southwest Oncology Group (Clinical Investigator) 1976-Nov. 1977. California College Honor Society American Cancer Society International Association for the Study of Lung Cancer (Founding Member) Federation of American Societists American Geriatrics Society (Founding Fellow) Professional Education Committee, American Cancer Society, Los Angeles Unit Research and Grant Peer Review Committee, American Heart Association Consultant: American Tobacco Research Council Chairman: Professional Education Committee, American Heart Association, Kern County Unit Member: Professional Education Committee: American Cancer Society, Kern County Unit -26-

324 Ci tRICUL:i)1 1'ITaE: MBIBERSHIPS (cont.) a ._';ER L. SICK, 'd.D. American Association for the Advancement of Science New York Academy of Sciences American College of Physicians American Society of Clinical Pathologists American Society of Hematology American Heart Association (Council on Thrombosis, Circulation, and Atherosclerosis) Association of Clinical Scientists California 'I'horacic Society -Z7- 325 1l~o"s 11 h o In !99 BICHTELER feron Svc. An /ue FlF.u T...4r.: S•+. Ss n>uo.. .nrv M.L E. EICEL - av d ne~uw .~0. iv. vn ielka r r r.Cu:a. . erwr w L.• avr<r ~Ar.p/ .•v !.u x bu1., wac Ma.x CwimseL M.i4eE Frd' .M1: ~rpi d Etld Uar• Nop $at6r YA 91.91 ffii LI_^STFIEA ELAUE uGB.LRR 1 LepnL Os, Mv 15, M. . N: s 1. '/EN.iIR FeM LevNunWrL4M.1].HDEFrert4n.iry).{1 RdEaiAa v~~ Hndel)e:{. 65.1 . mi prvE. buY~~w. Cv AG•b StuQ,e, fHS. uc PaL •ASSOC PROF MATIt {:\I• TE%. AL'STI\, )IMe. Ac MM Sv. Ra u"ry. rtprenupw IKeorl drepolopd paWe rd./EeMu. Mr4y AA! ..pdM.:eLn•rTnA.Y.TX11111 t:Z GEORGC EEERMAV, L.V'.p~ La S.P 23.1 f, . 65: s 1. E\TOMOLADY. ~::OG) Fd~TW.mL'sn.Klf.Mill:Con.ODU•,PIID(mmL61.F.dEaR w. Fmd L Drul Admie. LSDA La 1H I. DW 4dWut Suu D.F. Ca.r+•. La .a p.v/. L'u. M.w a~1 & TW.. Um•..LM, rs Frc! Um• SpN..4n :. 1L 1.. prd. CW~on Swe Cnl SL{0. FRDF EIOL ST MMYS COS, AD.fG Mas r< 1A.S. Evion Ss Aa Es Enlap 00- MrinF AdC Dep rMd N MMYl L,. Hovr 0.m. IA 4116 .I;Z [ATHERI~'E LnTNOSTO)lE• S FEI. C.e. US dem c 1 MELlOEIOLOOY. `TJCNENISTIII' El.c AWu U.n, ESC. SI. MS., 51.4v.. Lr•, PSD(ld1.51. ,. E•p In.v. ewcA.m. CaDF M« lP w. UKi• a'elsr.O.t 11.5., rp r. Sd Mr, Uv CaW, ls A.pla. 144I: rr FN I1al C.4/ Suu U.i., .-e1• f LeE E GswRan Um•.1P'6, ASST DIE \El ROL DIS PROO. 'AT ,ROLLCONN~\DISLST}O[E,iLMm.MA..eA.MS,N ... Rn A:rl...mn'. dwye. r.uk demsnu. w n4 W 4t.mrr.u•. Gi.aNrn d m. a<m>sw.uy dunden LwacDeai.ul dsa«q.l.um u ILM: -..W :.'rj'd ulcauuae M.i4µ ACG Em i1f Fr 4LE \el Im. \ervl l Co. _. 1 3. ,..e ' 15p w'ucawp A•. k ~sG. MD ]O41• .-.'1 c-IETM F. auw•i14. Vy Fr 1.,11, w 51,0 GEOLOGY Fd.r Y.4 NS !e PrD-ed1.11 Pro' E.p A.r Md INL TR uPNwv l la tr•, 5111'~ e cMmn d.IX Pd. UiE, PROi GEOL COL w~ILLL.M R MAET, f4 AAS~eGro: Sz Am Am Aw Peud Gwabpw, Aa GsMy. l.a Ea A n.:~{~.M~. Pedol>. .ppLStion d pemNnsn Ip pMppW F•ol4e. -S +x dDsw d Owi Cd d Y~'.6ay l Nvl \IW.mWrl YA DIIS I:~ NICl1AEL DAYID. S S-SIm. GW M. f, {1, . M.. ]. MOLECLUI HEMATOLOGY Ed.c. L'u• hW SvrA EA. N. LSi• SwrtMn CaM. 7.e.dl.11 PrdE.pF.IlqcA.v.M.n.rdMrSV6,tI•/1,41Vr a cLn Imri.a H.n.rd Mr S.A L CA~Crs'r HuF Mel Cv. l...w eeaa. au Mdnu4r Bwd,1..11. SCI DIR, SA\ /OAQI'il MEMAT E 0\'COL LAI. 1 J~KQ'„pLCO\TOL.FACME40STASISLU,1'Cl/Cas.nn.P" -..n Runf.. Cum Fvwl ll'1 L 1o:vo Mr FviW, M... t}l., p.,rL .. H.m.f Onm L.d 1..,1). Msa. Aa Soc MiaelpL Aa S.r C.0 4vl Ra> d Lm. sa . cWrrr MI Yns ~ahawry d pWm. p~pLipK ~1P, m kem..e4p ud waeia(/ MWUE AA! S.p laire Hro ~L Oecd 1.> I: ]lll En S~ EJSM.Y CA 51101 El~ PRFj ISANILTO\. S Te4le, OKe, S.p 10. M, ./l: < 1. INML~OLOOY. au Cv.. AE, ]0. Uu• M/[A. PpD(mwev?eES 11. Frd EaF OW Milpri .•a.. 0... ImmevC~W. KvaLn.L.IMt SiaLAS.. SwC.w 1LT1. Sc p.eua YW +SST PROF IMML\OL DE1R MICEOEIOL MED COL YA. TL ~ Pa AMnw Fped IeL 15-11 Ee A.uniw. .r rqu'.uv. r anprvn~ wW M.drwp AdC D.p d M.roSd Ep. M• MCY Su Y.e G d S: i Ic~GFR L[L S Su fl.e-so, Ctld'. N.P 11, fl MEMATOLOGY Feiul:m• Cr:.'. l- MD. 10 . hd E.F F.m .ur. M rotler ed K..n Cnv Hwp. E.L~,ll C.N. TSIl. Itl, E1.1L MEN FAC 'i 0T.;CL _V';5 CSL1F CTII MEALTM SCI LOS ANGELE111. MED DIE, 1.` .EA HENAT O'COL EES LAEL 11 Caeanmr Fz Dv .r rs A n K.m Cnv Hsp.111., wrnd l.n..olq.... S.eu Mauo Mr Cb. CJI. . dCXc~ 15. a e Irn.rolvpa L Idn i HuIJ Sn Cb. Lnr. Mape L Ur. Y~. b AWelew 1....an lyempwr vn~w Aa M..n Ar. Me. W a~.fv.u L Hemv.ur.. Am Sa. Hem.µ An Cuur Sa RsMessu.4 w wm d bemar4vi rec~.M[ ..J nr<wFWnvev) I,lu, aAeu.n ..asr muWVC`.-. 111 6rF F. Yvnom r a nKKV~eG.~.m.eW.a] nu ddu.m.uWUa.•.rWVmyd.nw ly `/ +u S.- Ivp.m N.1.r qsol GrM 11]T E,. S, W mEad CA p1101 5::1 it1EODOE[ A, e Fewly.. 1.'Y- Dv 15. M, m M... NATNENATICE EGW -_a. BS f1 L..~•ROCMU..M5.i0,TDler{adKllerl,.M hdE.ylnrudLL 5-Cau. /1 i., l.aa ru Fd b uw' ~rd. MM. ASSOC PROF •:O~ COL : Y. eL R4iv Am Nul~ S:. Nap Aw As 11s Eryv4 R.mry: v..Me Naarl..e,ve..L ar.LSUa MuLy A6L Dsp d ._ ...uv Cc~~S.em«ud/ AY 11106 1 i'l.aT. Tp[ODORE ALLCRT. S i1uh.L \Y. A W 15.13, . M: <1 ELECRICAL I`L: 'E EK:. G Educ 1Mm Hoplu. L'u•. EES,1'. MSE. 51, DCvL r P- 4F E_EC E ~0 5 .chvL.- :r YRAR'SE L~'I~. 1k D ~ ~Caxr.n~Ps v. depelsM •' ..~ Lu• C'. krLSky. T. Nra RI Lw E4r ! EMcvan EyR A. Nn 'a Sa U<a: 6 A>p: N.u. A.c Gap.~ Nu! Ea ~'aW.er.,aaw u~/w Irr - .I uWry. E Prcye..~.yl>rs iu yner ul Newl M¢/ Aoa D.M d E4T A CoePn Ey Lul MJI S/.Mr -L Sr..., \'Y I1110 Ei'_1[y C,pwl~ DAlTO. S Luu.'v, Er. V.e !1, .1: a fl. e 1 ECOWOMIC wl Ea;p0E TALOEOLOGY EAC L•e•LsrrN4.AE.SI.MY.fS. a. Pn~lee!.'0 PrdE.e A..:p•dpw.1PTl.yrmprueNmaSu4 -R GEOL S AM COAL CORF. 11. Cs:vnv+ Ps wenqou{L~a_..-KSMn SFWiLYJ6LreSrn.i.-prqPrv. ies • ~p\'D.L •r4°e. E_,.or Are.p..~ PrvL 1L)) Mm An AP P.vd GWapa Ac M.IKVI w, 1x. S~yv. %y AMS l. MJ.ca4E,. rynes.uo W obl/ dkw/ m.nr Muf.r4 Crsu.ee•rTvwl l.wp.ep.pll. eW .e.'...FRF: ° 'om• .vd e~rvavmm;a mp4y A eanp h.ekF.rt YWLy Adl MA. -+~c+-, Kn.uva O11 Twn 11- \D 11501 .:'t11 PSTiA 1, e 1~lurs. Rmna.. S.P 21. b. US euuw . Y. s 1. --EM.TICAL STAnmCS Educ Lu• C.W. lrn.k/. AE. 10. NA. fl. - .1 PeolE.p F.em..~prdu..v.pdrauu.t.'O.WMP '` S,~`^.ST.L~II-CALIF,EEKKELEY./6 Cnn<w•.nPa L.vc.lnpC+LUV• w: 5 G.yeMew F-.]0 \ATO v..~ 4L ta>1 Msm fe In.~ N.Y ~~~¢ s.w: Eorv Su4u Ss R. .~mwwrlrc uMiu~a..pwsuaK `• °^°N mei.+oM MnhW AC! D.P d Swr Ur• r C+41 EPee4/ CA f.fl0 VI _Ot W r~^ -. Mua 6E•vl tICCC Lu• fu' Ept f qQLlS tlCTLItT AGEIC. Swe 1:r. rul A.Ss N m/. SiSCEEIT FMAAN 1iF A ntlw A. Fu.- ~ewfoFr- Ifl }i.. 1111CVOR_ STATE P EuA... S.f1.4MLr. Tl'l, Pp FL~1Sz MuWlw DICSIOIL FETROL PnFL!v. {PZ k G-Mr l MruE A 2IRFORD 'FLROS M.F. . NELlOS DIEGOO e o,c w. r.c..r Phr-i ~ Ynps.. wP M Mau{ S pR"G ] Ear be. On C4m DOMNE p Ppr .M 1ICLLEI. F DEITSTS

325 "hOS `1i10 in theWeSt s 790. BICBTELER Am nn sa. A. As nn:n rr<Ten. s.ua Svc nryo a.nu+: Xx Ka Nu.xuao a nGUUw ..,E m.,n+. eewee DM11.e :.< d nG..:ar u m.6•cue teA bdol/. oecr :Arepf tiU. !Mr e.w 6vm,, er<,ree :Wa'+s Omwrv) MWmt Am 0<P d F.Gd Upi• XaV S<.10e FA 51)9f ~C8fE1.[1 aSLAVS ~aRi~D~a proW~nDlln l~rUnm. 15~5 npf EaP Ar m< 1. Lm• Hne<Ib<:F 64t <aa: pd. SwM..u Cu AG•ec S:W:u /b69. uv Pd. N]1. ASSOC PROF MATX. l:\II TE%. AL'Sn\, TI- M<m M. M.:E 5« Rs- I:.eeN aYV•nY. rep<.nuvoe tA<«F aupolvpol pv+pa.M yrku MWmt ACG DaPdMmE L'v.aTUA.OeT%]a]II EICi GEOMGE WEAMAI, 4 N<que. L. S<P IJ. 1.. a 15, T- E: TOMOLOGY. ZOOLOGY Eda TuWU l:v. ES, M. MS 11: C~tl Lu•, nD(-l.]. hof Eaµ ImP<vf. Fer E DrvR AGmm L.SDA.IA, JL•I I, &IG Aa4pa Suu D<P Cae<e.•, Ia Pa. L'en Nu<,.l.a E T<W<llni•..FK. w« Pa Um• 5«M.aw L.5639. pd. C1n«r Suu Cd 19i0, PROF EIOL ST MARYT COL 1\'D./0 Mew Fu AAwS. Ee:on Sac As R. Eiebp a00maa Mriy ALL 0" dEW M Maryt fd Hwe Dema IA N]1f ' IICE EATXCRI%E LIll%CSFO`IE, E PEI. Cr. I15 <ai<ac < 1 XEL'ROEIOLOOY. HISTOCY.EMISTRY Ua RWieLm•.RS<.SI.MSCfI.EreveLv.PIDIbd1.51. ha E,p Rn M.« aaMm. CaWp MM Ru La6, L'm• w'eun O.t SIS.. av ua Neloryc. MA. l:m• C.LL Le Ael<la 3911, .et Pa !d. UW Suv Usi.. Scl /.ccAnGle. IIJf a O<o</<n.n Lm.. ID]6 ASST DIR \ELROL DIS PROO. NAT IIST %ELROL E COMMI.~DIS l STROKE. )6• M<m. Am Au<1e,:o: AAw5. Am 5« }m: Rn N:n<an:6wu<, umk Gemrnu. <M nl.ud G<I<ornu•r GuvNan d m. Gemf<W<W 6uwGan Imlalumu7 aeame<q.uuen m Mls: Lu:«A<n:url d ulc~F:uwe MaiLN Am Rm 116 FW Ek6 \u W< \<va! Cm Du a S:, W< ]Sf0 wucmv:e Au< 9,0- MD )001• tICC [E~'~LTH F. au:n•ilk, vu Fe! la. JL m fR < l GEOLOGY 1- Yde l:+i., RS. M. MS 5s P6J:Jw17. SI Ro! E.D Au: Pe11<d, wu~:W:oe a Le lm•. Stil; .m« prd 61~N chmn Gep:lod.6,41. PROF GEOL COL wILLIAM E MARY, 6F Mrm AAAS. O<a Sz Am: Am Au P<ua D<aaluu. Aa GaopbY< Lmp. Ra S.vr~uN <nJ mn:.{-apl:i< I<ao1/. <DDlu,w: a avmpuun M Ltlo0u1 P•ea<m< Am DrP a G<a Cd a i"~'.:.m a Mary w~W.mabucE VA 111/] RICL 41CXAE1 DAVID, 6 Suct,n Gtil. /ae f. .f. m M: c 1- MOLECLlAR IIO:OGY. MENATOLOGY E6uc L'rv• Pvtn SwvG. RA 6E, Ua• SoucE<m CWf. PSDqc<II l maw.<uW ball, ll P,el E<p F<:6wc6<m. Narvard Mr ScA 11-). k; 6id c1:em. ]L:<. fel cw Im<,:u HanuG MrG ScG R CA:IG«i , H«F M<C Cv. •< na: m<m. RoA< IDV MaauW Iwl ]..11 XI DIR. SA% IOAQL'II HEMAT A OICOL LAR. InC't. DIR QLAL CO. TAOL. FAC HEMOSTASIS UE. I\G ]I.Cm<wm: Pe. F<L D.mae Ruerm C.ocn fou,G. 11 'J a Ee.m Mm fewG. Mr 1})., rumw,, t.r Arn Xew.: a Oewi lA4 Ive')N<m. Am Sa Mr.eE,a As Sa 4Y Ewl Rn R<E•~afw d/<M nPeum u cWrvN all Mea 6iab<muvl a pWm< PDUiD. n: a rLe:cal ran u Mm.nIW u,G en<o:ot1 MWU{ Am Lc Jepue Name, E 0- W lec 2127 E!< S: M6PYwG CA SJIUI !IQ PCrER ELM1L70\ 6 ToNlo OEiw 5<P ]0..5.. 11: < 1 IMMIIOL00Y. Ee:c AIAm CaL Al. )0, Uv Mv6. nD(mu+al:el} 11. h<I EaP O.: ,mm o6:a. K.ra:w. I:u. s:acLlum. SwMt. )S•n, rr~ Ir.<va.W mmwl D~• Imm. ASST PROF IMMLNOL DEPT MICROSIOL MED COL VA. 1L Coecunnl P. AMnm FwnO f<L 11-)E Re A<u•'a:w b6 n/u'aum a omPVn: a1b M<Jml AQO D<p: a Mne4d Ea< M' MCY Su MN Ctl a VaLEp_x.:\A:JI91 EICL RCDCE} LEL 5 Sn F- Cahl M<F 21. 42 NEMATOLOGY, O%COLOGY EG«- L'm• CaL!. Im:e. MD. ]e P<a EaD I<em mum u uvnJ PN. K<n Qre NwDE<LesReli tiu. -1. ftl. ]).tl. MEM FAC HEMEO`:COL L'~'IV CwLIF CTR HEALTM SGI LOS ANGELES. )}, MED DIR- RAY AREA NENAT ONCOL RES LAOS. I} Cvu:mal Pz Ilv ee6 ruc 1 6imu:a<a Ren D<e Nnp. ]}]<. uunG Eem.:ebtu: Suu Moew MN C1r. Qld. la-, Gv wca. )1 aluM h<muolcpn S: leh. a 1/<aIJ: Sn C4. Lnu Mw:e CYJ Cn N Wa Sci. Ls Aemek,. ]a., m<m tMemEmu <aue, Am Nren Au M<m le, f« TE.meEew E X<msl.av. Am Sa Hn- Am C.ec., Sa Rw. Nes«:.an u6 YwL ma6.:awn Y:<n:wm a Mmmuu mwc:aul tiJ 4eDulnoee7 ypu, E)p.,:.o<t-IaMa,) aeC N,enbw,a, eceurN uuWar.-•.111 ~ Y. Juneem el Mmwua:,<.,auul..nsu4{u:•<t elGnnm,n<:W mve•ucW.,myul.:.a W..Im{ Am L•. l- Xsm.: Oecd O<wp S»] EP 5, W<nF.M Cw PJ W I R1Cl TXEODOKE A, b R,mlln. NY. Da It. l0. m 56. << MATHEMAnC3 EA:v- Le:«. Ca.l3. 51.: n:• Rxl,n:n, MS.60. PED(nloG:< N<w5/. M Pra E<P Inu: vu:E. NoM a w.1L.m Seu:b Cda. 6)4. from aw Pd m uw pa. 64a6. ASSOC P0.OF MATH. t~ IO~ COL : Y, 66- M<m Am MuA Sa. M.:6 An Am Rn E:{a4c :M«1, b.vuoD.: <e.:.ua. ml rv.t6le N<ery. wear. eeG unFluo.. MW:eI Am DrP a M.N Uvm Ca kMxunf ~Y IIIM R1CGIT.TIIEODOREALIERT.EFIUE.L\Y AWIf.IS..f5:c1 ELECTKICAL EIOIIEEkI\0 EAa lam Hon- L'm•. RES.1'. MSE. ft. DEeS. N Pm<E.P Im.• <la m61oMa MapL,m 1659, km.5H1. Nam eu Pa u aaaa Pd.6}]0, PROF ELEC E%O. SYlUC15E L'NIV. lP CeacM,m: P« Vu sEOI.- s<pc rl« ey E mmPu: v,. Um• Cau( E<rE<Xy. )' Mam F</ Inv Elv a Ebcvemn EaN. Am Mn Sa. S« NOr: R ADp: Ma,E, Ax Cmpm NecE Rn Iou4e<M,Pavma ao~>ma.lm< tnMm. aw)u.. ,num u:n:wr. a ,cat .:vl>u, a ruec:me.~ <edfw u a>u.m. <ylP,uauG4:)J<w) MWmIAm-D<PdEM<aCamPmE4LWMWSYn<.r lm• Spec:.< -Y IJ110 /ICEEI. ED1wI:• DASTD. 6).w.~ RY. Vw !!. 11: f 6•, t I ECONOMIC GEOLO01' E. StAO%MENTALGEOLOOY EG L •IowNkAR.61 MS<.6f OIUOS haEaF Au: Pal a. P11.G:cmap a. Mmw Suu Cd' t D. -R GEOL. % AM COAL CO0.P. Cm-u<em Poa we.t youp ..onn<n 0,.: P:uv Renv,a P.q. ].- F<m~-<cue m+u.aetc,~ olf Eomrye•eC Spa:a. 1:5 FW E wuG1A<S<r•. ].., rmWt'S-T'. PM F-m•ee. ~DY R.pea.i Ee•vae A<.mmeel Y<at )4n M<m. Am Ar P<vtl QetlapaLL As MWCtl l:.w Pww, Sa, S:pe. l4 wAwi Ra MJSdotY..nvm.um uG rabt/ e( 6•W W f..W ew.menr Mopwr. CnucaarTnue<] 6•aaneei+pl:) coal ava'+c<01,F: tmoeca:mv .oG nvmm.n:el impac<a d e«:E! Gnebpnt MWs/ Am. XAm Col CoN Ku6amG OR TO.m lumwc6 ~D 51501 tlC[EL FCTE11 1. 6 EucNSa Ram.m. LP ll. <e. US muna m M. < i MATNENATCAL srwnsna EGur lu• C.IJ Ren<k). Al N. MA. /1, RDf,u,v,i. t) Ma E.p From .u: pcaf m wac Pa c.ua,. 6:-•0. cbm< MP '"1. PROF STATIST. ~NI.' CALIF. tERKELEY, ]6 Co:vunam I« L.cv.ImF Ca, Um• Inrw.I- 1 S O.yt<M<,m FwmG kI.10. \ATO MI. `<.)5 Mem Feam: Muli Snmt Am Swm A<D. Ea]u Suu: Ss Rn v'vepafam<v,c tuwun <MUmav. ..y,w:c m.:Aeb M.JeM Am D<p d Suau L:r• d CWf EPtakf CA M/I0 11QEL aOREKT Joe+.6 EnuaNk. K)..a t 16 . s a) MATgEEIAI)D'. .'- . L'm• La~s•JI<. AR. JT, \«<f.raun Lm•, 1fA al. L'm• I•~,a1.<~., = P<d Eap Tucb<:- puE ecM. K.. 1:4I fnc - m.a« 1}1 ll DRE%EL lN IROF M TX fP ASSOC XE . 644 . , <. w . , Ap Dp1 ~ E Ate Aa: S« Irut a ApFi M.N Iv<r 55iI1 Rn AaJ.~ MM E -, A.nl.e: <er Meuy AGi DvP d WIN DnuE L'r• F•iL6ry1: PAfF~_ ~ )IC1EL T1fOMA5 RICNEL E D<vdL M.A ~e• 30 I1 m N ALO -• ~E~ ... Lc• M:<L RS. $/ Mw 60. F-D-JU. ef Fa Eep lmc: m.a. Ma In ~~ ~ 64:, au; pd.{ ].», ASSOC PAOi MATN. DAKTMOLTi GOL 1Y If~ ' ^ snuueD6o1 ~~ .M7[vr:p leYcve~ SSUT AmD<P d MmE Danmvu:d Ca X.pmu AX 0J1S] A??: RIfSLL•t1I11AV SAMLL_! Om.ll.. h luv t. JI E%PERIKE~TAL PCOCP F. Svu ,S9.DP.).1YER4 .. . Flnio, {f, hem ru p<vf M.ua p<eL 6}'S. PROf PNYSIQ L'." ARM !L ~" As nn Sz Ra SDavmmpr Gupuun tuo:ic p6fun 4n-o.mp. d~ ' mear,mn a ma M d e.cMt ieu a<uum tln.iyv r~ ~«aY YFPo rd< Plne I lya omasula MWUE Am D<p eL nl'uu L'u• d Ant T:oa AZ Efy - . `_ 1 ' 1p1.6 w Rl¢EL9ALFF. Elon EWwi uwlm. n.lu L. a...R.l t33Atia: ~IERN..u L'•':S 5.E(,: <il Rp<ay ,x, Sf Ra E<P 1<w rsremv <ea Ckmavn Ca. fIS5I. hm D:•. E- C-r* ' ' .Pe Dc•. 5152.:v..a <eQ sy clur' nveeulL: m6 Mmv~a_ E< ~ ~ DL 59i1, SE CE:.AMIC E%OR- SOLTiER~ RES IVST. 6} Mm Av 5 >V~I 3 R M l : 4 A l l a r uir. <cwv : c<xD As C a Swa Pwaln d.yp~, hm mAv ef - vwn <su is eN,u, tYCVUUe< Pa:PUUaa. <i.c~,ri rm<Lm) ol K uYa M.JYy 4G[ Sa.`~ f ` Lu :OOC \ma w.r Swu Euvue5lu:a AL J I01 RICIERMA\', 61'LA' A b\r Y«L \'Y. On 16. 11. n.I: <)!F4• + PXYSIOLOOI.CL1\'ICALPNARMwCOLOGY EGUC G1umR<::en EA>\p` Sf. VY Lm•. MD 39 hd E<P CHIEF ASTXMA-EMIHYSp1A ~.F:~ COLL'MR:wPRESRI MED CTR. 41, C«uwnr P: Rn Id .r a 6. a: im6 lm R S.alM Mmv.r Y:.)] . p1 p~ <4L sd un. Cr6i.1 Dm NsF. le:es .Sa6. .u, cW praE Cd Rsai~ fu: Pom Cdumbu Lm•.1'.M. «.x <n_ Pc.1{.:5, Pe!.'1., Nwi\'e. Ywt. 6}:1. R.oolh<•ea K<m X«F. SurtaL C.~-:). a E A.~ ~' Mees, \t. /l~. m tnF<n:M lat A mlu'Alwe U<: G<D. Froce DeLSrtl I(4yt(~ Yerl.61'S Ynr.>IOnemp6YVm.lo:Cm/C1u<:Du Le PE)<Kiu.. Rua Nmi. \"r. 1«L )6'l. m:mG DEruc•.n. ]F, nm: tl• P<a F.4' ~W A W•n~i~'~ n A mM<<o(.AAs6.YVaeTT<-.P+ufMQ,t.ft • ucon : M,e A C C R --.,t.mdF.v.-ba S f RnpamOn pl:n~aen .nG :.a.-apmrt d)eu<au .,-1 cE:on., eww:,v+~ t~-. speciait Xurme:ebp<:Ee-.%. G<.rbpmn: a~me mN<LUn a mEalm. t~F? icld~ i a+oaeb <eY P.r.a xnum{ V.WUE Am Cel a R.•.~. a sy.<. CWoM<Lm• ~<. len \Y 100I) < ~ RICS:ERSTAPF. THOMAS AL1ON. ma1M-saou w I10: RIQEIT. 11'1LW.M CEORCL E Evmeccl <;DeC A/ S, F/:.lL.:.. AORICLLTL'RAL E4OI~"EERINO Lfuc \DY Suv L:m. RS.19 MS tlIW, Suu Lei•, P601.F retl 6a Ra E.D Rn un Y, m,6 xOn 5uv L.• ftfRUR:- tur a m,u u u.a Pd, 61]I. PROF AGR E~L. MICN STATE LTT,'ltEt Am Sw At< Enpt Ra Mu<:et,TUra N'Lpxm,. Aa.M, La« wLUUa L~'; /dsuae 1<cilil.e . xm umu Y)out n.vaemnml i af r Suu Lt. Em: L.e.W M: YI:< Mi::n/ AGGD.y: a AD Evt Mv a1C\ERTON. ROlERT EEItEL b Eul L:•e.-mol. 0" 0<: 1. M. . FXA0.MACOL001 EGuc Lm• P,~t!•. RS. 56 MS. EaF S: ne DM1mm<oiK+~ Mfl :m:c r.Gr. 6I<1. !cx m1t v A.t~ Flurm.cx fii5. Cv F6.rrvw.<vu::•..]Gb. s a 92 !F, <].e in M]S...T an artun, )}]1. SR 1' PRES SC) AFFAIRS. \Olw'ICN IHARMACALCQ T:-lt:~-. Am Rmm<c<u: A<a Am Sa M1u:wcN l E<PTE«.P<:n Rn Mr<MVUm dss {<wlapeen: d anW Yp<'<ea:.e Grvy MuYe/ Am. \«acb.Enm PEUfam/tCtC. Ifl Xcnrl: "Y 11113 tICCFORD. LAwxL CE RICi1wRD50~. E EI®a \Y. Xmla 11:..1,<1 f~ 5']ATE 1.1 SICS E<uc Atl<N Lm•. IS <1. Mw la.. Tanevl. nDlyn!c.Gtll- E.D Aua Dra p6nia Sua L m• \'Y Ca Cmmw. AI!nG a9V, m y6/v dfaAl, m pe <c.. Rn Cv. 6:61. Gv m lef. tol) e.1<pan. Il-6! 6v mrmw! 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