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Lorillard

Clinical Record Tissue Examination Dog 5035 Enviro Control

Date: No date
Length: 23 pages
01422980-01423002
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Author
Auerbach, O.
Alias
01422980/01423002
Type
FORM, FORM
SCRT, SCIENTIFIC REPORT
Area
SPEARS/EVPOR
Site
G65
Date Loaded
05 Jun 1998
Document File
01422934/01423110/Inhalation Studies Dogs Pmo Bioassays Related Material Enviro Control 75
Request
R1-132
R1-004
R1-042
R1-043
R1-045
R1-046
R1-053
R1-061
R1-068
Named Organization
Enviro, Enviro Control
Author (Organization)
Va Hospital
Litigation
Flag/Trial Exhibit 6989
Stmn/Produced
Txag/Trial Exhibit 6989
UCSF Legacy ID
itl88d00

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Page 1: itl88d00
oaunauacu rvaau uau _ • ' Rev. Jao. 1057 l l ter P ga romu • By Bureau of the Budget Circular A-3: CLINICAL RECORD •SPECIMEN'SUBMITTED BY OPO d0-14-81431-1 , --D-o-g-56-35-- TiSSUE EXARlIiNATlON Enviro Control . LDATE OBTAINED ,AJL-~_.- i~. ~ SPECIMEN. w ORfEF CLINICAL HISTORY (Indude durationaJlulon and rapidity o/QrowtA,i/a neopdAsm) OPERAT/VE FINDINGS P'OSTOPERATIVE DIAGNOSIS I SIGNATURE AND TITLE PATHOLOGICAL REPORT NAME OF LABORATORY Laboratory of the Senior Medicali ACCESSION NO(S).. Investigator, VA Hospita1F East Orang,e, Ne .7-0 I nng 5(135 (Qrou deatrlpNon. Atttadopia examination and dlapnotra) TONGUE The mucous membrane is intact. The tissue cuts with usual resistance and'on section the muscle is firm and browne bronchi is smooth and brown in appearancee LARYNX 1 The mucous Ambrane of the epiglottis, true and false vocal cords, aryepiglottic folds and infraglottic zone is red in appearance. The surface, however, is smooth. Lying in the anterior wall of the trachea, approximately 411cm. from the vocal cords is an oval opening which measures 8mme by 7mm. The edge of the opening is grey in appearance. The remainder of the trachea and major bronchi as well as the branch . LUNGS The lungs were not weighed.* (Continue on reverse aide) PATIENT'3 IDENTIFICATION (For typed or written entries dira:Neme-last, Aret, middle; srade; , dat et. hospital or medica7'(aility). Dog 5035 TISSUE EXAMCNATION'. r tltsn(larY1 ] Orm bIa O V ~IS-lo5
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, t > , ~ . Standvd Ferns 502 ~ . R.r. Aupuil 1954 ' ,-, Rureau of M.. Wdyai. ` -- CSrculot A--32 DATE OF ADtd155ION DATE OF DISCHARGE • .~~_....4 ., . n.S..GOV1AMyart.rel.nNCOVIcec!3-1c-R1oiS•14UwaW ' CLINICAL._RECORD NARRATIVE SUMMARY _--Dog 5035 TA 1ZED HOS surface of the parietal pleura and the parietal surface-of the visceral n.leura are , smooth and shiny. The pleural space is patent.- PI _L NUtdBER OF DAYS Page 2 -- (Silnated'ds7eaten o narrat.rs `~" '-~ In a fixed state, the left lung measures 21cm. in the apicobasal direction, lOzcm, in the mediolateral direction and 6cm. in the anteroposterior direction. The visceral surface of the parietal pleura and the parietal surface of the visceral pleura is ..smooth and shiny. fihe pleural space is patent. In a fixed state, the right lung measur~s 21cm, in the apicobasal direction, 15cm: `°in the mediolateral direction and 7cm. in the anterbQosterior direction. The visceral The left_.apical lobe-measures 8cm. -in-iep greatest apicobasal direction. --The --<- lobe is brown in appearance and is firm. tissue"euts with slightly increased resistance and on section the lung parenchyma is firm and brown in appearance. Lying in the apical portion of the lobe are occasional fine grey bands. Beyond these•are occasional dilated air sacs which measure less than lmm, in diameter. The lung parenchyma in the remaining aspects of the ,._. ~ap-.,. red in pearance and slightly firm. ,..~ ,: , . ._ _ of the lung parenchyma is The base is just iieneath the pleura. . The remainder _ extending'just beneath.the pleura Is a wedge-shaped focus which.measures'8cm. by 611cm, ,. . ; . _ . _ . , . ,- -. .. . - . _ ._..,.-i .. .. - .~ . ..~7 by app~ey Ximatelq 14iscm. The "apex of t~e raedge' `faes toward 'the hilum b f' "the ' lobe. the a.obe is red *n appearance. Lying in the anterior portion of the lobe and of the,.lobe. In the superior aspects of the lobe are fine grey bands. At the peripheYy of these grey bands are occasiona~ dilated air sacs. The remainder of The Ieft.diaphragmatic lobe measures 9hcm. in its greatest apicobasal direction. The tissue cuts with greatly increased resistance, particularly in the inferior portion firm and red in appearance. .The ft -cardiac -lobe measu-res° 6'~cm.- in its greatest :,apicobasal direction. ---`The -- - ~ tissue cuts, with sl~.ghtly;increased resistance and on section the tissue_is firm in alspeaiztnce for the most part. In' areas within -the robe, particularly tn the - superior aspects, are occasional fine grey jands. The remainder of the lobe is also ,c , (Use additional sheets of this lorm (Standard Form 502) if more space is requrred) .:, SIGNATt1RE OF PfiY5tC1AN - - -~ , - •° ' DATE IDFJ LTIFIGATIOM N0. I.ORGANIZAT1OPl The fight°apical`2obe measures~-101jcnt.,in its greatest apicobasal direction. The tissue cuts with slightly increased resistance and on section shows the presence of occasional fine grey bands, particularly in the superior aspects of the lobe. At t4e-periphery of these grey, bands are occasional dilated air sacs which measure less `'than `1mm, "in - diameter, `Iin the remaining aspects of the lung tissue the parenchyma is firm and brown in appearance. -:c. w~=, w PATi{:NT'S LD£NTIFICATION! (For t~pedors•trtt6n.entrrositirw Name-last Frst { REGjSTER NO. =----- 4 WARD NO. -" __ ,•` -' = I : F=_. r- triiddls trad.; dats ho2p(t.Cor atpd~at laoi4tr) Dog 5035 ~' HARRA?iVE SUMMARY ~ { acan:annt Farm 802 _ : _
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y a Siendard Form 502 Rev. AVgust 1954 lureav of the Budget Clrcutm A-32 Y:a. sov[waw::RT rn:vTr!:: orruc c{3-]0-51oi:+-1 {e1C`OJ:1 CLINICAL RECORD I NARRATIVE SUMMARY Dog 5035' S A D . DATE OF ADMlSSION I DATE-0F DISCHARGE (I -' - (Sidn and det. it end of narrafir.) PIT LIZE 1 NUMBER.OF OAYS HO I Page 3 The right cardiac lobe measures 8cme in.its greatest apicobasal direction. The tissue cuts with slightly increased resistance and shows fine grey and red granular zones. Present in the superior portion of the lobe are occasional fine grey bands. At the periphery of these grey'bands are occasional dilated air sacs which measure less than 1mm. in diameter. Y ~ The right intermediate_,lobe measures 3;fcm. in it9_greatest apicobasal direction. The tissue cuts with usual'resistance and on section•shows the presence of occasional fine grey bands. At the periphery of these grey bands and particularly in the superior aspects are occasional dilated air sacs which measure less than 1mmo in diameter. The remainder of the lobe~ etains its resiliency.- The right diaphragmatic lobe measures 9cm. in its greatest apicobasal direction. The tissue cuts with slightly increased resistance and shows the presence of occasional fine grey bands. At the periphery of these grey bands are occasional dilated air sacs which measure less than 1mm. in diameter. The xemainder of the lobe is slightly firm~and brown in appearance. TRACHEOBRONCHIAL LYMP:i NODES The left superior tracheobronchial lymph nodes measure 3cm., cut with usual resistance and on section are brown in appearance. The left inferior tracheobronchial lymph nodes measure 7mm., cut with usual resistance and on section are brown in appearance. The right superior tracheobronchial lymp4 nodes measure 1cm,, cut with usual resistance and on sectim are brown in appearance. . The right inferior tracheobronchial lymph nodes measure 3;lcm., cut with usual resistance and on section are brown in appearance. HEART The heart weighs 171.9gms. The visceral surface of the parietal pericardium andthe parietal surface of the visceral pericardium are smooth and shiny and the pericardial space is patent. There is the usual amount of subepicardial fat present. There is the usual amount of clear fluid present in the pericardial cavity. (Uee additional aheete of this form (Standard Form 50?) if more space is required) SIGNATURE OF PHYSIGtAN DATE IDENTIFIGATION NO. I ORGAN171.TION' PATIENT'S lDENTIFICATION (For !)~p.d or sjltfen.en(riea qi 'ra • ::.cmrlaal, Arst, utiddle; lrade; dat.. 6oapitalor mitdiial:[hcilUr~ Dog 5035 NARRATIVE SUMMARY etandar[L Form ao-Z so_-lu7
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Sloedard ' form 502 " Rn. AugYlt 1954 :. _ . _ .._.._... _ _ _ .. -_lure" ef ttie e„aaet --e... 5ovt..yrrr retNTiao oFicec ei3-t,-8:643-f 4,•;-os:i ¢ircdar A-37 ~;:=Gf.1MlCAL RECORD NARRATtvE SUMMARY Dog 5035 The veins are.thin and pliable. The lumen, is patent. _ The t,3,ssue Aows- no, evidence pf pathologic` change... F € LIVER The liver wei$hs 4S4'Ygms..The liver-edge isu sharp..-._The,.liver_supface,is smooth 3:'.::~-:.S:... . ~.S ~ . . .... .~ .t.a~:~..~ 6.•- - .. ,.. .. .-. -.. . _.-._.-._ .__..~-...._~.-___.- __- (I7ae additionai eheeta oR thia 7orm (5#andard Forrn 30?) if more apeae isi"tiired) c , DATE OF AOMISSION I DATE OF DISGHARGE ~ (S1A n and dats at and oF narratirs) NUMBER OF DAYSHOSPITALIZED~_ Page 4 _. The.;wall-of the right atrium-measures 1mm. in thickness. -The endocardial surface ptnooth. ~The,auricular_appendage has some red clotted material at_its apex. . It will be _ determined whether •thi•s terial is an ai3te=mortem"thrombus) :-`- The- tricuspid valve measures 7cm. in cirumference. The free edge is thin. The hordae teadineae•are in areas fused. -1'hey,are not_.th3ckened and not shortened. '~.; ..> - _ __ __ .... _ . . . - _ ._ .. . .measures. 2mm._in. thickness. The apex is rounded. The wall of the right'ventricle. The papillary muscles and trabeculae carneae are'also rounded. -The lumen is greatly enlarged. The pulmonic valvesmeasures ,4cm, in circumference. The pulmonic cusps are not thickened; not`shortenet and are-not fuseda ' 'i-..r wa11 of the left atrium measures 2mue, in th3ckness. The endocard3al surface is smooth. The apex of the.auricular appendage contains small amounts of clotted ~lood. It will he determined on-micorscopic examins..tion whether this-is an : _.. _ .. _ . ~ _ .. -- ante-mortem thrombus. The endocardial surface issmooth. The mitral valve measures 6kcm. in circumference. The free edge is thin. The chordae tendineae are in Itr_eas fused. -They are not thickened are are not shortened. The wall of the left ventricle measures 11mm. in thickness. The apex is sharp, 1~e muscle is firm and brown. ~he trabeculae carneae and papillary muscles are . . _ _ . -- rounded. The aortic valve measures_ 3~m. in circumference. The aortic cusps e not thickened,-not shortened and are not fused. The coronary arteries arise in-their usual location. The coronary ostia are patent. The coronary arteries are patent as far as they can be traced. They contain no yellow athermatous . i~,._ " AORTA irlaques. - ^ . _ ! ... ~ _ . _ - . .. _.... ~.... _ .. _ .- .-..- , ..- y~" ' 3<'he ao`rta retains its resilienc _.There-are no yellow athermatous p7.aques along the c urse of the aorta, VEINS StGNATURE O! PH.YSlC1Ari -DATE IDENT'iF1CATlON NO. ORGANIZATION -~ ~ ~-'.. .. ~-. .. . t.-... ..... .... ...- .. _.. . 1 Y.... .._ PAT18TlT'S1pEN'r1FICAiION (Por trp.dor wrytt6rtsicntri.ellaciGlr) . glve:JYanr.-laat, A[~t,. ,~ REGISTER NO, ddla;. iddla; rado; date:.hawpitwLor mtld m i ~Dog 5035' C; NARRATIVE SUMMARY ~ 8UndarQ Form 30: 502-107
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f,. t ifond.rd Form 502 Rer. AugutT 1954 aur.au otthe Rudget CGrcvlor A-32 a.9. GOI[.f:~!C/'i Fi1ItiT1ti:ORl{^C cl3-U7--91LL:%-1 dU~} C~u CLINICAL RECORD ~ NARRATIVE SUMMARY Dog 5035 DATE OF ADMISSION ' DATEOF DISCHARGE NUMBER OF DAYSF_tOSP'ITA<.iZED Page 5 (SiQn and dat. at end' ol narratire ) M and brown. The tissue cuts with usual resistance and on section the sinusoids stand out prominently. GALLBLADDER I The gallbladder measures lmm. in thickness. The lumen is patent and contains the usual amount of clear,green bile. The cystic, fiepatic and common bile ducts are patent. ` SPLEEN I The spleen weighs 35gms. The capsule is slate-grey in appearance. The tissue cuts with usual resistance and on section the splenic corpuscles stand out prominently. ADRENALS The adrenals are.present in their usual location. They cut with usual resistance and on section the cortex stands out prominently from the medulla. The cortex is rich in lipid. KIDNEYS The right kidney weighs 49.5gms. The capsule strips with ease leaving a smooth surface. The tissue cuts with usual resistance and on section the cortex stands out prominently from the medulla. The pr.tex and medulla together measure 13mm. The cortex 41one measures 7mm. The mucous membrane of the calyces, pelvis and ureter•is smooth and grey. The left kidney weighs 47gms. The capsule strips with ease leaving a smooth surfacea The tissue cuts with usual resistance and on section the cortex stands out prominently from the medulla. The cortex and medulla together measure 12mm. The cortex alone measures 7mm. The mucous membrane of the calyces, pelvis and ureter is smooth. URINARY BLADDER membrane is intact. The urinary bladder measures 3mm. in thickness. The lumen is narrowed. The mucous (Uae additional sheets of thia.form (Standard Form 502) if more space is required) . SIGNATURE OF BHYSICIAN I DATS IDEN.T{FICATION NO. IORGANtZAT1ON PATIF.7VT'SUWEN[TtFIcAT1ON (Fort,Fp.dorwp(ttbn.er) ~ eeQira,•,Nama-1aat,Rrst;. atiddle; arade; date:-hospifai.or cmdlaaLtay) Dog 5035' I REGISTER NO. I WARD NO. lNIRRATIYE SUMMARY : etanda>,a Form 601 ~ si}2-tu7 . N N CD GD
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~ •.~ ~ • S/eqdard Fsrm 502 • Rw. Augu+t 1954 Ilyreau e11he Rudge! Clrculor A-32 V•i. :DYt~lltlCNi~r.INT1~G e.rlCr N3'-16'-fi101: 1 {UG-O:fJ •----CL1NiCAL RECORD ' NARRATIVE SvMARY Dog 5035 DATE OP ADMISSION (Sign and a a e e arf3/ti7d j'-" ti PROSTATE The prostate measures 22mm. by 2cm. by 2cm. The tissue cuts with~usual resistance and on section the prostatic urethra is patent. The tissue shows no evidence of ' DATE OF D15CHARGE I NUMBEROF DAYS HOSPITALIZED -Page 6 -TESTES AND EPIDIDYKIDES pathologic change. The testes and epididymides cut with usual resistance and on section the testes _ ~ - - -- - ~-:... - . ., ,.. . . :.- .. .. ._. _ __ . _ E.•.~ , _,.. _ .... __ . Themucous membrane of the hypopharynx is smooth and grey, .. ~ . ~ . ~ _. .. .. ~. ... . . .. _ _ : . string easily. 5.-~- - GASTROINTESTINAL TRACT ESOPHAGUS The mucbus membrane of the esophagus is smooth and grey. The longitudinal folds are,.pxominent. ~ - - _ The mucous membrane is intact. The rugal pattern is maintained. STOMACH DUODENUM ;rz The.mucous membrane is intact. . ~; ~-.. .-. ~ JEJUNUM The mucous membrane is intact.__ The villi arev prominent, ;.s ILEUM ,. - . .. - ;. c: .~c. . ... _ ri+o ..•+r.: ..- -t. _-..~5:z-.^- 1TR.~?.. FI ~_ ~..n _.. ,. . .. .. `€_ C'u_' The mucous membrane is intact. The villi are prominent. ~•_. _~. ..~. . . . CECUM s~`,-.^Y~Yc.n-.... ~..r! ~2`-~~_ . •1..,:. (Uae additional sheeta of this form (Standard Form 502) if more space is required) SIGNATURE OF PHYSIGIAN DATE IDENTIPICATIONMO j'ORGANt2ATtON The cecum _iueasuXes _ 8~cm, - It ~-cmts. -wi.th usual.resistance and on'sectian the mucous «Si4 ~....-+._.._ . . - . PATIENT S IDENTIFICATION (iFor typed or writYen, en trie. grvet Name-Iast, Arat, REGISTER NO.arTiddle jred~; dah; hoepltal or atpdieatfartlity? ~ p~y i-... _ ..~ `..- -. . .. _. . ._. . -.-. ., •-•- .. . . ... . .. __ . ... . _,. Dog 5035. BtnnCard Form 302 ~_ 4 ~;lut ui _ : svT WARP -'!O. r'- `a"-'--- j-"'-' )1ARRATIYE SUMMARY
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Standord Ferm 502 Be,. Augol,i 1954 Nureau ofthe,ud4et Circalar A-32 CLINf CAL RECORD !~ 1 Y.s.GavcRr:S[NrrllaiIkGOllleC RlJ6ir: 4416. 039 NAR1tATIVE SUMMARY Dog 5035 DATE OF ADMISSION DATE OFOISCHARGE NUMBGR OF DAYSHOSPITAIIZED Page 7 (Sign and d.te at and of nartatire )' membrane is intact. COLON The mucous membrane-of the ascendin~ colon is intact. The mucous membrane of - the transverse colon, descending colon and rectum is intact. The anus is lined by a smooth grey surface. PANCREAS The pancreas weighs 36.3gms. The tilsue cuts with usual resistance. On section the normal architecture of the pancreatic parenchyma is maintained. DIAGNOSES 1. Pulmonary fibrosis and emphysema, slight 2. Thrombus, right auricular appendage 3. Pulmonary infarct, left diaphragmatic lobe SECTIONS TAKEN Bottle A - two sections left apical lobe Bottle B - two sections left cardiac lob.e ~ ~ . , Bottle C - two sections left diaphragmatic lobe Bottle D - two sections right apical lobe Bottle E - two sections right cardiac lobe Bottle F - two sections right intermediate lobe Bottle G- two sections right diaphragmatic lobe (Uae additional sheeta of this form (Standard Form 502) if more spaco is required) SIGNATURE OF Pfi`LSIGIAN DATE IDENT1FlCAT1ON NO. IIIORGANIZATION PATIENT'S IDENTIFICATION (Fot tFp.d or ortjjten_e!iiee divs: Netna-laat, Rrat, middlr; prada; dats. hoapitAl or n=diaqLlaWity) Dog 5035
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q - t . SlandaYdF6Yre 502 R!Y_ Aa,gost 1954 6t0'.dev o[ the B7dqa1 V.S. GQYC.NI!tvT.PALItLING OJrfCC taa-1fN104.i-I vri U:! Grator A-32 CLIN]CAL RECORD , NARRATIVE SUMMARY - Dog 5035 4 DATA OF ADMISStON brown granular pigment. The walls of the alveolar'septa, particularly in the-subpleural DATE OF DISCHARGE -Nl7MBER CF CAYS HCSFITA4IZED I " , ~ ..._.._ I_.._._ Page 8 ° (Signsnd date.at end otnatrative) , 1LAI'.&-:ILA2 & LAS & LA31 LEFT APICAL LOBE The:capillaries of the interstitial tI ssue are moderately dilated an&filled with blood: rLying in the,lumens-of many of the alveoli-are accumulations of_serum, red blood cells and _:alveolax phagocytese Some of the'alveolar phagocytes contain . p ~ i arteries are of average thickness. The bronchi are lined by columnar epithelial cells I and'Show A'slight to moderate increase in the number of.basal cells, the nuclei of - which vary slightly to moderately in size, shape and staining character. The overlying plettra•.is slightly thickened by an increase of connective tissue. regions, are slightly to moderately thickened by collagen fibrils, fibroblasts, and histiocytes. In the regions beyondithese the alveolar septa are torn to leave enlarged_air sacs.';These findings are iore advancel"in-Slide-LA5, :Lying,in the lumens of some of the pulmonary.arterioles and pulmonary arteries are thrombi composed of red blood cells predominately with serum, occasional neutrophils and mononuclear cells:"".In Slide 1LA1 there are red granular zones (necrosis). Within these zones there is an alveolar filling process. In the alveolar filling process are nuclear fragments, neutrophils and the ghost forms of red blood cells. Intact red blood cells are also present. Within the alveolar septa are nuclear fragments. At the periphery of these zones some of the alveoli contain neutrophils and alveolar phagocytes. Some of the bronchi are filled with neutrophils, desquamated epithelial cells, serum and a few red blood cells. The pulmonary arterioles are slightly thickened by pink hyaline material The ulmonary DIAGNOSES tissue.;_,The elastic framework of the lung parenchyma is intact. The internal elastic lamina of the arteries is intact. The walls are of average thickness. . ._ T.,. • ... Lr .--- -- --, . - .. The°elaatit:a-van Gieson stain'`shows the elotic fibers intact at the pleuropulmonary junction. The averlying pleura is slightl~ thickened by an increase of connective 1. Emboli, branches of the pulmonary arteries and arterioles, recent 3. Pulmonary fibrosis and emphysema, slight to moderate 4. Brown pigment and fat granulomata - 0T) i! more space is req~t;re~. - - (Uae aalditioaa_ sheets of this torm (Standard For~ S _ A SIGdATORS AF Pf11C5LC7AQ8 ---_-- - ._ -_ .- _- -r DA DENT1F1CnTLON NO, 1ORGGANf_Z,ATION PATIEN1DENTIFICAT10N (,Fai typ edor written entriee jive: Name laet, 1ir,at, sniddla: Qrade: dete: tioap(ta( w medicqf facslt(Y} , Dog -5035 . ~ Pulmonary infarcts, recent ~'REGISTER NO. WARD-NO. NARIUi1YE. SUMMARY Qi __ etanaesa torai^ao^ ..-
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Steedard Ferm 502 t.e. Aoqast 1954 Bureev atlh. BedgefQrralae A-92 CEtNICAL RECORD DATE OF ADMISSION us. corE-r[ar PnlNnac orjl4c. .1J-11--S1015-1 4111, 11%!I, NARRATIVc SUMMARY Dog 5035 ''DATEOF,OlSCHARGE_ ` -- ~NUM©EROFDAYSHOSP~Tl~L1ZED _! __ Pa_Se 9-- (Si/n and date at endof narratire)' . Edema and congestion . Acute bronchitis 7. Bronchopneumonia,,recent t 8. Basal cell hyperplasia, slight, with slight atypism . 4. 9. Fibrous thickening of the pleura, slight to moderate 2LCI & 2LC2 & LC31 LEFT CARDIAC LOBE ~ The capillaries of the interstitial tissue are moderately dilated and filled with blood. The walls of the alveolar septa, particularly in the subpleural regions, are slightly to moderately thickened by collagen fibrils, fibroblasts-.and histiocytes. This is best seen in LC31. In the regions beyond these the alveolar septa are torn to leave enlarged air sacs. Lying in the lumens of many of the alveoli are accumulations of serum, red blood cells and alveolar phagocytes. Some of the alveolar phagocytes contain brown granular pigment. Present within the lung are several foci of varying size which are red granular in appearance (necrosis). Within these areas the former structure of an alveolar filling process is still discernible: Within the alveolar filling process are the ghost forms of red blood cells, intact red blood cells ' an&nuclear fragments. Nuclear fragments are also present within the walls of the alveolar septa. In the areas around these zones the alveoli contain neutrophils, red blood cells and alveolar phagocytes. Some of the bronchi contain accumulations of neutrophils and serum. Branches of the.;pulmonary arterioles and pulmonary arteries contain emboli aahich are composed of red blood cells predominately, neutrophils and mononuclear cells. The bronchi are lined by tall columnar epithelial cells and show a slight to moderate increase in the number of basal cells, the nuclei of which vary slightly to moderately in size, shape and staining character. Branches of the pulmonary arterioles are slightly thickened by pink hyaline material. Branches of the pulmonary arteries are of average thickness. The overlying pleura is slightly to moderately thickened by an increase of connective tissue. • is intact. The walls are of average thickness. The elastica van Gieson stain shows the elastic.fibers intact at the pleuropulmonary junction. The overlying pleura is slightly to moderately thickened by an increase of connective tissue. The elastic framework of the lung parenchyma is intact. It is also intact in the region of the infarct. The internal elastic lamina of the arteries (Use additional aheeta of this form (Standard Forn 502) it more space is required) . S(GtVATURE OF PHYSICIAN I DATE IDENTIFICATION NO. I ORGANIZATION PATIENT'SIDERTIFTCI~T(ON (For typed or written entries qive:ll~eme-teat; firat; rnidtlfs: arade; datr, hoaprtal or tnedicaf faci(ity) Dog 5035 I REGISTER.NO+~. . i, WARD NO~. . NARRATIVE SUMMARY Standard Pbrm 60: X!.-id' .
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~ [ Slandard Form !02 - R.r.. Augus/ 1954 r w.av of th. Dudget JiS.GOYC{JS_•iUlj/n.IKrI`IGOrlICu Mlo/-II HICU:1C s' Gau/er A-32 ~.~=:CLlNjCAL RECORD I : NARRATIVE SUrJ!MAR`l .-Dog 5035 DATE OP ADMiSSjON I DATE'OF DISCHARGE NUN{OER OF pAYS HOSPIT!ALIQGD _ I Page 10 - -- (Sign an: a e a on a narra ,YCI'-'_ DIAGNOSES J> ~-;<-- - - G. . . _._... G::, . ~ . _ . Pulmonary emboli, recent, branches of the pulmonary arterioles andlarteries .-3. ' Acute bronchitis, recent 6. 2. Infarcts, recent .Bronchopneumonia, recent -6.--Edema and` _congestion 2A.' tx ' . Pulmononary fibrosis and emphysemi, slight to moderate ~ . : LJj,_.,:-Basal,.cell ~hyperplasia, s1.ight _to moderate, _with sl ~ rj i't 4 r, r, r [i r r'^',l °.Y! i fi? °_ _ _ ~L.. 1$.:: ;- Ar, t@riolosclerosis, slight . to ~.~'..."~ ., t?_+~•~a s+ ._ 1'.. -.._ . !_ - , :~~.tit._ ~. NwFi4rous,, thickening of, athe pleura, _s_light . slight to"moderate atypism r`~- .]~t~~n- . t~.Yr .... h ~ .. " .. . . ., .~~' .,,._ . . ._...,. ..,..._ .. ... _ ~. ~n a_~ Ya °` PAI(~7ae addiliona} sheete of fhia farm tSfandard'Form 501) i~f more space ia required) ,cells.,:_.-The pu]pwoary, arterioles j3re_ :a_l.ightly thic:.ene.d b y pink hyaline material~: - _ay = ,c,vlumnar: _epithelial 'cells and show_:a -slight tq Snoderate increase 'in ::ttie numberr af basal $ccSUaulatiors;s Qf, neutrophils, serum and: red bloqd_ :ce].ls.. The bronchi are .lined by tall Ihe:capillaries of the interstitial tissue are -moderately dilated'and'fillect with ,bl:ood.-:;_The walls of the alveolar :septa, particularly in the subpleural .regions. an& &iarticularly in Slide LD28,tare moderately:thickened by•an increase of~connective ivAssue.:- Aare_ thexe .are..fibroblasts and histiocytes. -In the regions beyond these the (giveokar -septa are -torn to ieave enlarged;9air -sacs.- -The -}:~umens -of many~f the YalveoYi ~.oq.tai.n:accumv,~.ations of serum, red blood cells and alveolar phagocytes. Some of the ls_lveolar contain brown granular pigment. :Present also within the lung are small and ,jlarge ,aized -foci ;whic.h. _are .pink gtanular in sppearahce_' ?, Within -these' areas 'the ghost ~orms g.f an _alv_eolar filling process and the alveola.r septa are -still discernible. ~Within the alveoli in these regions are nuclear 'fragments, red blood cells and the -_ ighost._£orms .Q£. xed _bloo.dd cel].s.,- W.ithin the alveolar s,epta are nuclear ..£ragments. pThe;#ulmonamy_arterioles: ;and -pulmonary .arter.ies- _ron.tain emboli composed of red blood cells, a few neutrophils and a few mononuclear cells. The bronchi contain Teutrophils.and desquamated epithelial cells.' In areas the alveoli contain '- =- 7 7 .......lE . .". .r.~._- ~~~.. _3LD1 & 3LD2 & LD24 & LD28 & LD64 & LD12 & LD121 LEf'T DIAPHR.AGMEITIC LOBE SIGNATUREOf PHY£SkGIAl1F., i+:; D+STe -'<-Z, + ~`tDENT7F1GAT10NN8 F ORGANiTAT10M--_' PATIE NTi51DENTIFICATION. (For t pe r wrs tten .nfriaa grv Nama laat flrof., ; REGISTER NO. WARD NO. _ nu.ddle Qrad~ (dat.yhoa.talor m.d.cnlf.orht )I aDog 5035 °"'r19ARRATI1/E SUMMARY &owndutvi rorni S02 o~~-~:_:':^~~"il1_-'~. _.,..

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