Tobacco Documents Online

Comment: Increased number of infarcts noted in Group 67'(PMO) dogs and a greater number of lobes involved. of the cigarettes is higher. Group 32 (HN) dogs show greater nurrbers of infarcts than are found among,the low and moderate nicotine group. Pneumonia occurs secondarily to infarction and a corresponding increase is noted especially among the dogs of Groups 32 and 67. Apparent trend of greater numbers of dogs with higher degrees of basal cell hyperplasia and atypia is-seen in the groups with the increased nicotine content of the cigarettes. " Likewise, there is a trend to greater numbers of dogs with increased degrees of fibrosis and emphysema in the groups as the nicotine content With the exception of the unusual number of infarcts among the Group 67 (PMO) dogs and the dogs smoking high nicotine cigarettes (Group 32 (HN), the changes noted above have been far less than was noted among dogs who smoked in our previous study groups.

6ft (BORRISTON LABS) ECI SMOKE INHALATION STUDY CODE 11 CODE 13 5322 5213 5238 5350* 5189 5221 5184 5258 5343 5295 5354 5306 5363 5195 5162- 5335 5245 5163* 5261 5050* 5327 5198 5197 (Removed):5236 5174* 5292 5072* 5352 5114* 5339 5337* . 5132* 5120 5084* 5279* 5332* 5300* 5089* 5204* CODE 32 5048* 5175 5190 5223 5154* 5349 5301 5359 5209* 5097* 5035* 5206* 5200 5266 5318* 5085* 5166* 5277 5364 5194* 5360* 5141 ** (no dictation)5297 5328* 5073* 5202 CODE: 67 6005* 6025* 5138* 5087* 5121 6022* 5063* 5030 5178 5278 6024 6027 5130* 6015 6001* 5094* 6021* 6034* 5051* 5303* 600 8* 5185* 6017* 5127 5065 - **5297-Insufficient tissue received for pathological'study. ., .,-, , ..~ .,..., RECEIVED SHP OCT 2 9 1979 (*EX CONTROL SHAM 5224(no dictation) 6019(no dictation) 5152 5168 5307 5170 5186 5107 PIRED) .

M BORR'ISTON RESEARCH LABORATORIES SA-12 PROJECT Dogs in Enviro Control Study: Total Number of Dogs Received (10/1/79): 98 Incomplete: : 4 Total.Number of Dogs inReport (5/1/79): 94 -- r r DAYS BCH F & E PNEU- BENIGN INFARCT NUMBER REMOVED SMOKED ` GRADES GRADES MONIA BRONCH. (No.LoC P OF FROM, (AVERAGE) GROU S TUMOR Involv DOGS STUDY (MEDIAN) -1 1 1+ 2 3 0 -1 1 1+ 2 3 (No. Lobes Involved) Control , 2 No Non- 5 Dicta- -- - - - - - = - - - - = 1 1 (2) -- Smolcer , tion . .. . Control' . Sha m 3 - - - - - - - - ill - - - -- . 2 (2) . . J , ,- { 191-930 _ F 13 -(LN) 19 „ 1 (552) - 16 2 - - - - 13 ' 4 1 - 4 11 (14) 3 (~ (5412-470) 188-979 11 ,(MN) .16 a1 ' (585-587) 12 4 - - - - 6 10 - - 4 7 (11) 1 (E . ~ii 50~}030 J 3 HN) 2 ( 2 6 ; 1 522 ~ - 6 7 2 - - - 4 1 - _ 1 (6) ~ _ (547 .,._ . • . ~ 34-71] 67 (PMO) 25 -- (290) 1 10 0 10 4 - 2 1 5 7 - - 18 4 (6) 15e (~ (231) • . ~ ._ . Figures indicate number af dogs with ind'icatedrfin:dings. BCH - Basal Cell Hyperplasia -F & E - Fibrosis and Emphysema Grades: -1 Very Slight . 4;:;.frades: . 0 1 Slight -1 1+ S1 i ght to Moderate ,- 1 A - .t. 51 2 Moderate 1+ 3 Advanced 2 _ 3 Absent Very Slight - : N - Slight ,~ Slight to Moderate~:; Moderate '' Advanced