Tobacco Documents Online

Scientific Advisory Board Floyd E. Bloom, M.D., Director Arthur V. Davis Center for Behavioral Neurobiology The Salk Institute Doris H. Clouet, Ph.D. Assistant Director New York State Office of Drug Abuse Services William M. Harvey, Ph.D., Director Narcotics Service Council of St. Louis Jerome H. Jaffe, M.D., Professor Psychiatry Columbia University Harold Kalant, M.D., Ph.D., Professor Pharmacology University of Toronto Jack H. Mendelsom, M.D., Professor Psychiatry Harvard Medical School Norman Weiner, M.D., Professor Chairman of Pharmacology University of Colorado Medical Center *16*

. Board of Directors Patricia E. Bashaw...Vice President, Resource Center for Women Herschel J. Brown...Director, First National Bank of San Jose; Former Executive Vice-President, Lockheed Missiles and Space Company Leonard Cornell...Attorney; Realtor; Former Associate Professor, Denver University Law School Avram Goldstein...M.D.; Director and Founder of Addiction Research Foundation; Former Chairman of Pharmacology, Stanford University Catherine Lee...Attorney; Board of Directors, KQED Joseph~0ren...M.D.; Director on Immunology and Respirato.y Di:..:ase, Syntex Research; Clinical Assistant, Professor, Stanford University Joseph Schmedding...Retired Executive Vice-President, Bank of America; Former member of Trustees Committee, San Francisco Foundation Vartan Ghazarossian...Postdoctoral Fellow in Laboratory Research, Addiction Research Foundation Henry P. Organ...Associate General Secretary,, Stanford University Martin E. Packard...Ph.D.; Corporate Vice-President, Varian Associates; Former Trustee, San Francisco Foundation Wilbur Watkins...Management Consultant; Former Presi- dent, General Paint Corporation; Former Executive Administrator, Palo Alto Medical Clinic Philip N. B1iss...Special Counselor/Consultant, Palo Alto Unified School District; Consultant to California State Department of Education Donald E. Yost...Management Consultant; Former Operations Manager, Fairchild Semiconductor Charles G. Schultz...LegaI Counsel *17*

BOARD OF ASSOCIATES * Creighton Peet, President...Retired Vice President, Safeway Stores, Inc. Mrs. Alfred Bochner...Former President, Holbrook Palmer Foundation; Member, Board of Directors, UniomPacific Bank Richard S. Dinner...Partner, Dinner Levison Company; Vice-President, Graduate Theological Union Mrs. Genevieve di San Faustino....Member, Board of Trustees, The Bothin Helping Fund Burnham Enersen...Partner, MeCutcheon, Doyle, Brown and Enersen, Attorneys David Faskin...Investments; Member of the Board, California Association for A.C.T. Peter Folger...Retired Chairman of the Board, Folger Coffee Company Crawford Greene, Jr...Partner, McCutcheon, Doyle, Brown an&Enersen, Attorneys Richard J. Guggenhime...Attorney, Heller, Ehrman, White and'rlcAuliffe; Director, Institute of Medical Sciences John Huntington...Attorney; President, University of California-Hastings Law Center Foundation * Mrs. Charles B. Kuhn...Vice Chairman and Treasurer, .San Francisco Foundation Mrs. Matilda Manning Kunin...Civic Leader in many Bay Area organizations Francis A. Martin Jr...Advertising Consultant; Board of Direc-tors, San Francisco Ecology Center Edgar N. Meakin...Consultant John F. Mi11er...President, Hunter, Miller and Fleming, Estate Management * Emmett Solomon...Retire&Chairman, Board of Directors, Crocker National Bank 0 6-h * Brooks Walker, Jr...Chairman, U.S. Leasing International, rCh Inc.; Chairman, San Francisco Foundation 0 W * Wilbur L. Watkins...Former President, General Paint •~ Corporatiom; Former Executive Administrator, Palo Alto 00Medical Clinic * EXECUTIVE COMMITTEE MEMBERS

Excerpted from The New York Times October 2, 1977 4piate-L~~e Substances in B rain MaYHold Clue to Pain and .Mo 0 Th di' cov oC i stmiiari...l >ietw-rn substaitcei produc,ed by the hu• r+an hrstrr a-nA::hlr the QDiLm yoooy has - --n realm of body chem= istry, offering-ctuel to the nature of pain, pleasure. the emotians and perhaps, such mattars as-epilepay, drug addiction and ' me~tal Illaess. The climactic finding. which has gen-{ erated a flurr}y of scientific effort;•~ wasi that the brain and the body"s master gland, the, pituitsry, nukelthe.ir'own na- tural substances that appear to.act like morahi;+e„ aez opium derivative: In the two•years since that, discovery, a whole nevK family of suctt• substances ! has been ideatitied. They . are. called en- ~ dorphine, a::coioed word• meaning "the morphine within_" Seldom hap a new-fidfd•oU.biological research stirred-such •wideapread••excite- ment, sv• swiftly. ThQ newly: discover chemfcals .. are; ,at once, clues •and toof through chicb 'sciefltistt: hope to brin into focus nsw vistas.of bra•rR-function, "It ha= rTMatM a1 mtch e'csitGIIlent neuroacience as. a;ny field`in•- the Ias u etades,' th.re is.ao • quesqo at; _said. nr. witliam;.Bunne F ,_ haLjjs;Jt e ° g • chemis ~QnSernin~ p~,. epi- le23y. and eirnt2l ilin sa ar'-h ino• deve(. ° _ . _ ° " o>:~tteatdng~ some c~ a c°a ac°a of a~hi Ooh[tn12 aild deDression S *19*

. ..M r Excerpted from The San Francisco Chronicle June 16, 1976 Research Sdentsts iProbe A MorphineLike -Hormone BY Chart.s p.rit stance, helos control the ser drive = but the hor=ones now under study are thouant to piay• a muca more buot e part in Laa ce ra e cttet^.t U tnterp[ay t at tncyatew astects a person s per- son Lr., z:^.u otnavior. "It s one of ' the tncst frnrtfu1 Per3ocs our rne aS:;n, s r. . e ti7n n=oac o[ the uvers,rv o_f or-..u3_ en rer ere ~ a t eeHuay meet•.ag or e docrne Society got under way at the Iiilton HoteL 4fuch of the current activity cen- ~ ters on a neri y vd f hormone, en orp w Iln an tzst tu sru esoe aves muca e+ morpnine, even t ou its c ecuc3 ~' ,, r any mown•opta ~ * In' searching for other chetnirrls which attach to the same sites, a r13ss of smaTl pt•oteisLs,, or peptides, was di'scov- ered. lt was noticed that these peptides were actuaily small sections of the larger lipotropin earlier studied by Li.. Just in the past two •years,'the theory has been developed - backed up by persuasive animal studies - that. somehow production of lipottropin, or its breakdown into the smaller endorphins, plays a crucial role in controlling the. brain's moods, emotions, and sensations of pain_ _ Goldste[n. wbo ts also dirEctor of the Addicnon Research Foundanon in P o Alto, sa1 tn a te e one [ntervtew t at in juat t e past iew montns in " Ia bratory more morptune-tt' e' com- p un nave aen coua tn antsnal brams an p[tuitary btantts. "We will robabl find a whole- famll o t ese ormones. " he sai .' t may weil lead to recoa_nanon of an entue y new system or neura ' contro Scientists at art international meet•• Later, largely because of wor's br Inc here yesta ay escn bea growing pharmacoloezst Dr. . vrara ezn at excitement over e recent discoverv of Stan2or n,versity an r°3earc ers at a c.a5s of ^attiral nol'L7on!'S tsceGI to the ~ ucuLe tn JaD Ie;o, e benave znuca Me morptund. soecifJc site9 [n brain nerve ce to 3lany hormones are hown to ~` ~ch moc-oatne artachey ~ere [ entf- f ied. contaroY tnood* - testosterone, for in. - *20*.

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