Tobacco Documents Online

r. n St~u.•ecrd'F'orm 502 .. .._..~' IV~ , ~L!\i'CAL 2'F•CJZG -- IS,1 ;:tI','; . . .. g •rl•/ L.r' l• r~ .... w 6. Basal cell hyperplasia, slight 7. Focal calcification, left apical loo,• 8. Fibrinous pleuritis, right 9. Squamous metaplasia of the trachea and of the trachecvs tnmy s i't(- 10. Fatty infiltration of the myocardium il. Passive congestion of the liver, spleen and :ridnc'.ys C0`MLNT There is little information which we have receiv+r•(I on til::: dclr;. 'i''-. ::: c; ~._ series of P~IO dogs. The dog died'~ on ?i;.y 17, 1977 afr~•r t,a•.rin~ :;^c,~c c' 3!?'' ':i, t nicotine cigarettes for a periodlof 39 days. The ct1angc•s in: the i~un-g zri.• those of a massive pulmonary infarction1which involved al' seven iobr_G. The c:au:;:• of t::e' infarction was the presence of a recent thrombus in the ri-ght auricutar aape;auage from which multiple emboli seeded into all lobes c+f tinrr .ur,5. !Iz r.ioq the recent infarcts, there is also evidence of a hronei,opneumon i a. ..., bronchopnuemonia is of varying extent in the different Lories of t+l~ is not an infrequent occurrence. The presence of prnur,lonia a well ?cr.own fact. It is rather interesting that t;ie •.zu, uivc o;: Lninrct to::;ic*.;in_g only 39 d'ays of smoking,. In the first study of smoning oc;;s wilicir ..,r, n~ .crrtd we found' that pulmonary infarction' may occur early pnrt.icuiarly ia ~~-:1)nicotine group. This dog along with Dog 6005 on PMO cigr.; ~ ctc :; sioo,,r:, ;1ito p-r >;~ nr 0inC irct ion early after the onset of cigarette smo'xing, The i'n ti,c remr;in,rc. l'un; a re minimal. There is some rup ture of the kra l ss t, i' t-! 1-, n l va c, ?•-i r.,. :' r1 "1Yj the presence of acute edema nnd conges tion, rupturr• anri ee ;,-i ng oi Li:~ ~!lv: : t nr ti~•p t a m,y, occur. There is a basal cell hypFrplzsia but it csr,r :: t,or- << of atypism'. The inflammatory processes in addition ec- rilc timo;tia~ r.»~ ,.n Ilr•,• llyi,orpl3sia of the basal cell. SenSt,r ''-c d :?, i f i ,• _rc.ti n; ~~.1_ c+t- .. il.~r nddit'ion.il sltcCYs of[his larm. ~.'!.qrr!:rf.i r'r•r.r-t . n-r- .;IG'L:T:Jfi!i OFrIpY51C1/c`J QATZ: , / . • ••r:rJT5WL;N.TiFICATIUN (For r,j+ndnrnnr:rn-.~:rr~~wrvo.L~..r.r~~ noia~:~: AIr.,fr; cr.rfr-;:r,•.paa!orrnrdlca7(:.C::rri. Do- 6025 e..•Ft' ~._.